|
G |
Abcg2 |
ATP binding cassette subfamily G member 2 |
multiple interactions |
EXP |
Tadalafil inhibits the reaction [[Aflatoxin B1 co-treated with Ethanol] results in increased expression of ABCG2 mRNA] |
CTD |
PMID:35608386 |
|
NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
|
|
G |
Adipoq |
adiponectin, C1Q and collagen domain containing |
multiple interactions |
EXP |
Tadalafil inhibits the reaction [Epinephrine results in decreased expression of ADIPOQ protein] |
CTD |
PMID:29233027 |
|
NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
|
|
G |
Aif1 |
allograft inflammatory factor 1 |
multiple interactions |
ISO |
Tadalafil inhibits the reaction [Thioacetamide results in increased expression of AIF1 protein] |
CTD |
PMID:31323263 |
|
NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668
|
|
G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
EXP |
Tadalafil inhibits the reaction [[Aflatoxin B1 co-treated with Ethanol] results in increased expression of AKT1 mRNA] |
CTD |
PMID:35608386 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
|
|
G |
App |
amyloid beta precursor protein |
multiple interactions |
ISO |
Tadalafil inhibits the reaction [Streptozocin results in increased expression of APP protein modified form] |
CTD |
PMID:34428446 |
|
NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
|
|
G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
EXP |
Sildenafil Citrate promotes the reaction [Tadalafil inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]]; Tadalafil inhibits the reaction [Cisplatin results in increased expression of BAX mRNA]; Tadalafil inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]; Tadalafil promotes the reaction [Sildenafil Citrate inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]]; Testosterone promotes the reaction [Sildenafil Citrate promotes the reaction [Tadalafil inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]]]; Testosterone promotes the reaction [Tadalafil inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]]; Testosterone promotes the reaction [Tadalafil promotes the reaction [Sildenafil Citrate inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]]]; zinc protoporphyrin inhibits the reaction [Tadalafil inhibits the reaction [Cisplatin results in increased expression of BAX mRNA]] |
CTD |
PMID:20574430 PMID:32621855 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
|
|
G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
ISO EXP |
Tadalafil inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein] Sildenafil Citrate promotes the reaction [Tadalafil inhibits the reaction [Streptozocin results in decreased expression of BCL2 mRNA]]; Tadalafil inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]; Tadalafil inhibits the reaction [Streptozocin results in decreased expression of BCL2 mRNA]; Tadalafil promotes the reaction [Sildenafil Citrate inhibits the reaction [Streptozocin results in decreased expression of BCL2 mRNA]]; Testosterone promotes the reaction [Sildenafil Citrate promotes the reaction [Tadalafil inhibits the reaction [Streptozocin results in decreased expression of BCL2 mRNA]]]; Testosterone promotes the reaction [Tadalafil inhibits the reaction [Streptozocin results in decreased expression of BCL2 mRNA]]; Testosterone promotes the reaction [Tadalafil promotes the reaction [Sildenafil Citrate inhibits the reaction [Streptozocin results in decreased expression of BCL2 mRNA]]]; zinc protoporphyrin inhibits the reaction [Tadalafil inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]] |
CTD |
PMID:20543097 PMID:20574430 PMID:32621855 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
|
|
G |
Bdnf |
brain-derived neurotrophic factor |
multiple interactions |
ISO |
Tadalafil inhibits the reaction [Streptozocin results in decreased expression of BDNF protein]; Tadalafil inhibits the reaction [Thioacetamide results in decreased expression of BDNF protein] |
CTD |
PMID:31323263 PMID:34428446 |
|
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
|
|
G |
Becn1 |
beclin 1 |
multiple interactions |
ISO |
Tadalafil inhibits the reaction [Streptozocin results in decreased expression of BECN1 protein modified form] |
CTD |
PMID:34428446 |
|
NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
|
|
G |
Bmp2 |
bone morphogenetic protein 2 |
decreases expression |
ISO |
Tadalafil results in decreased expression of BMP2 mRNA |
CTD |
PMID:32513693 |
|
NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
|
|
G |
Casp3 |
caspase 3 |
multiple interactions |
EXP |
Tadalafil inhibits the reaction [Cisplatin results in increased expression of CASP3 mRNA]; Tadalafil inhibits the reaction [Epinephrine results in increased expression of CASP3 protein]; zinc protoporphyrin inhibits the reaction [Tadalafil inhibits the reaction [Cisplatin results in increased expression of CASP3 mRNA]] |
CTD |
PMID:29233027 PMID:32621855 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
|
|
G |
Cat |
catalase |
multiple interactions |
EXP |
Tadalafil inhibits the reaction [Cisplatin results in decreased expression of CAT protein]; zinc protoporphyrin inhibits the reaction [Tadalafil inhibits the reaction [Cisplatin results in decreased expression of CAT protein]] |
CTD |
PMID:32621855 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
|
|
G |
Ccnd1 |
cyclin D1 |
multiple interactions |
ISO |
Tadalafil inhibits the reaction [Streptozocin results in decreased expression of CCND1 mRNA] |
CTD |
PMID:34428446 |
|
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
|
|
G |
Creb1 |
cAMP responsive element binding protein 1 |
multiple interactions |
ISO |
Tadalafil inhibits the reaction [Thioacetamide results in decreased phosphorylation of CREB1 protein] |
CTD |
PMID:31323263 |
|
NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
|
|
G |
Ctnnb1 |
catenin beta 1 |
multiple interactions |
ISO |
Tadalafil inhibits the reaction [Streptozocin results in increased phosphorylation of CTNNB1 protein] |
CTD |
PMID:34428446 |
|
NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
|
|
G |
G6pd |
glucose-6-phosphate dehydrogenase |
increases activity |
EXP |
Tadalafil results in increased activity of G6PD protein |
CTD |
PMID:24911673 |
|
NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
|
|
G |
Gata4 |
GATA binding protein 4 |
multiple interactions |
ISO |
Tadalafil inhibits the reaction [Doxorubicin results in decreased expression of GATA4 protein] |
CTD |
PMID:20543097 |
|
NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636
|
|
G |
Gcg |
glucagon |
decreases activity |
EXP |
Tadalafil results in decreased activity of GCG protein |
CTD |
PMID:24911673 |
|
NCBI chr 3:47,113,914...47,122,958
Ensembl chr 3:47,113,914...47,122,929
|
|
G |
Gfap |
glial fibrillary acidic protein |
multiple interactions |
ISO |
Tadalafil inhibits the reaction [Thioacetamide results in increased expression of GFAP protein] |
CTD |
PMID:31323263 |
|
NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
|
|
G |
Got1 |
glutamic-oxaloacetic transaminase 1 |
multiple interactions |
EXP |
Tadalafil inhibits the reaction [Aflatoxin B1 results in increased activity of GOT1 protein] |
CTD |
PMID:35608386 |
|
NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
|
|
G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
EXP |
Tadalafil inhibits the reaction [Aflatoxin B1 results in increased activity of GPT protein] |
CTD |
PMID:35608386 |
|
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
|
|
G |
Gria1 |
glutamate ionotropic receptor AMPA type subunit 1 |
multiple interactions |
ISO |
Tadalafil inhibits the reaction [Thioacetamide results in decreased expression of GRIA1 protein] |
CTD |
PMID:31323263 |
|
NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283
|
|
G |
Gria2 |
glutamate ionotropic receptor AMPA type subunit 2 |
multiple interactions |
ISO |
Tadalafil inhibits the reaction [Thioacetamide results in decreased expression of GRIA2 protein] |
CTD |
PMID:31323263 |
|
NCBI chr 2:165,949,379...166,069,510
Ensembl chr 2:165,947,521...166,069,510
|
|
G |
Grin2a |
glutamate ionotropic receptor NMDA type subunit 2A |
multiple interactions |
ISO |
Tadalafil inhibits the reaction [Thioacetamide results in decreased expression of GRIN2A protein] |
CTD |
PMID:31323263 |
|
NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637
|
|
G |
Gsk3b |
glycogen synthase kinase 3 beta |
multiple interactions |
ISO |
Tadalafil inhibits the reaction [Streptozocin results in decreased phosphorylation of GSK3B protein]; Tadalafil inhibits the reaction [Thioacetamide results in decreased phosphorylation of GSK3B protein] |
CTD |
PMID:31323263 PMID:34428446 |
|
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
|
|
G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
multiple interactions |
EXP |
Tadalafil inhibits the reaction [[Aflatoxin B1 co-treated with Ethanol] results in increased expression of HIF1A protein] |
CTD |
PMID:35608386 |
|
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
|
|
G |
Hmox1 |
heme oxygenase 1 |
multiple interactions |
EXP |
Tadalafil promotes the reaction [Cisplatin results in increased expression of HMOX1 mRNA]; Tadalafil promotes the reaction [Cisplatin results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [Tadalafil promotes the reaction [Cisplatin results in increased expression of HMOX1 protein]] |
CTD |
PMID:32621855 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
|
|
G |
Il1b |
interleukin 1 beta |
multiple interactions decreases expression |
EXP ISO |
Tadalafil inhibits the reaction [Oxygen deficiency results in increased expression of IL1B mRNA] Tadalafil results in decreased expression of IL1B mRNA Tadalafil inhibits the reaction [Thioacetamide results in increased expression of IL1B protein] |
CTD |
PMID:16368379 PMID:31323263 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
|
|
G |
Il23a |
interleukin 23 subunit alpha |
multiple interactions |
ISO |
Tadalafil inhibits the reaction [Streptozocin results in increased expression of IL23A protein] |
CTD |
PMID:34428446 |
|
NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923
|
|
G |
Il27 |
interleukin 27 |
multiple interactions |
ISO |
Tadalafil inhibits the reaction [Streptozocin results in increased expression of IL27 protein] |
CTD |
PMID:34428446 |
|
NCBI chr 1:181,173,108...181,178,720
Ensembl chr 1:181,173,372...181,178,582
|
|
G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
Tadalafil inhibits the reaction [Thioacetamide results in increased expression of IL6 protein] |
CTD |
PMID:31323263 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
|
|
G |
Ldha |
lactate dehydrogenase A |
multiple interactions |
EXP |
Tadalafil inhibits the reaction [[Aflatoxin B1 co-treated with Ethanol] results in increased expression of LDHA mRNA] |
CTD |
PMID:35608386 |
|
NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472
|
|
G |
Mapk1 |
mitogen activated protein kinase 1 |
increases phosphorylation multiple interactions |
ISO |
Tadalafil results in increased phosphorylation of MAPK1 protein Tadalafil inhibits the reaction [Thioacetamide results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:18082193 PMID:31323263 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
|
|
G |
Mapk3 |
mitogen activated protein kinase 3 |
increases phosphorylation multiple interactions |
ISO |
Tadalafil results in increased phosphorylation of MAPK3 protein Tadalafil inhibits the reaction [Thioacetamide results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:18082193 PMID:31323263 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
|
|
G |
Mapt |
microtubule-associated protein tau |
multiple interactions |
ISO |
Tadalafil inhibits the reaction [Streptozocin results in increased expression of MAPT protein modified form] |
CTD |
PMID:34428446 |
|
NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
|
|
G |
Mtor |
mechanistic target of rapamycin kinase |
multiple interactions |
ISO |
Tadalafil inhibits the reaction [Streptozocin results in increased expression of MTOR protein modified form] |
CTD |
PMID:34428446 |
|
NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
|
|
G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
multiple interactions |
EXP |
Tadalafil inhibits the reaction [[Aflatoxin B1 co-treated with Ethanol] results in increased expression of MYC mRNA] |
CTD |
PMID:35608386 |
|
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
|
|
G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions |
EXP |
Tadalafil promotes the reaction [Cisplatin results in increased expression of NFE2L2 mRNA] |
CTD |
PMID:32621855 |
|
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
|
|
G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
EXP |
Tadalafil inhibits the reaction [Cisplatin results in increased expression of NOS2 mRNA]; zinc protoporphyrin inhibits the reaction [Tadalafil inhibits the reaction [Cisplatin results in increased expression of NOS2 mRNA]] |
CTD |
PMID:32621855 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
|
|
G |
Ogn |
osteoglycin |
increases expression |
ISO |
Tadalafil results in increased expression of OGN mRNA |
CTD |
PMID:32513693 |
|
NCBI chr17:15,032,069...15,052,626
Ensembl chr17:15,032,069...15,052,739
|
|
G |
Pde5a |
phosphodiesterase 5A |
decreases activity |
ISO |
Tadalafil results in decreased activity of PDE5A protein |
CTD |
PMID:15934858 PMID:16368379 PMID:17138653 |
|
NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701
|
|
G |
Pfkfb3 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 |
multiple interactions |
EXP |
Tadalafil inhibits the reaction [[Ethanol co-treated with Aflatoxin B1] results in increased expression of PFKFB3 mRNA] |
CTD |
PMID:35608386 |
|
NCBI chr17:66,983,629...67,064,702
Ensembl chr17:66,983,686...67,063,125
|
|
G |
Ppp2ca |
protein phosphatase 2 catalytic subunit alpha |
multiple interactions |
ISO |
Tadalafil inhibits the reaction [Streptozocin results in decreased expression of PPP2CA protein modified form] |
CTD |
PMID:34428446 |
|
NCBI chr10:36,358,110...36,377,864
Ensembl chr10:36,358,101...36,377,862
|
|
G |
Prkg1 |
protein kinase cGMP-dependent 1 |
multiple interactions |
ISO |
[Tadalafil co-treated with Thioacetamide] results in increased expression of PRKG1 protein; Tadalafil inhibits the reaction [Streptozocin results in decreased expression of PRKG1 protein] |
CTD |
PMID:31323263 PMID:34428446 |
|
NCBI chr 1:228,409,605...229,638,794
Ensembl chr 1:228,408,947...229,639,080
|
|
G |
Prkg2 |
protein kinase cGMP-dependent 2 |
increases expression |
ISO |
Tadalafil results in increased expression of PRKG2 mRNA |
CTD |
PMID:32513693 |
|
NCBI chr14:10,559,882...10,668,479
Ensembl chr14:10,559,882...10,666,888
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
Tadalafil inhibits the reaction [Streptozocin results in increased expression of RELA protein modified form]; Tadalafil inhibits the reaction [Thioacetamide results in increased phosphorylation of RELA protein] |
CTD |
PMID:31323263 PMID:34428446 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
|
|
G |
Slc2a1 |
solute carrier family 2 member 1 |
multiple interactions |
EXP |
Tadalafil inhibits the reaction [Aflatoxin B1 results in increased expression of SLC2A1 mRNA] |
CTD |
PMID:35608386 |
|
NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
|
|
G |
Syp |
synaptophysin |
multiple interactions |
ISO |
Tadalafil inhibits the reaction [Thioacetamide results in decreased expression of SYP protein] |
CTD |
PMID:31323263 |
|
NCBI chr X:14,849,444...14,864,553
Ensembl chr X:14,849,444...14,864,745
|
|
G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
EXP |
Tadalafil inhibits the reaction [[Aflatoxin B1 co-treated with Ethanol] results in increased expression of TGFB1 mRNA] |
CTD |
PMID:35608386 |
|
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions decreases expression |
EXP ISO |
Tadalafil inhibits the reaction [Cisplatin results in increased expression of TNF protein]; Tadalafil inhibits the reaction [Oxygen deficiency results in increased expression of TNF mRNA]; zinc protoporphyrin inhibits the reaction [Tadalafil inhibits the reaction [Cisplatin results in increased expression of TNF protein]] Tadalafil results in decreased expression of TNF mRNA Tadalafil inhibits the reaction [Thioacetamide results in increased expression of TNF protein] |
CTD |
PMID:16368379 PMID:31323263 PMID:32621855 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
|
|
G |
Vegfa |
vascular endothelial growth factor A |
multiple interactions |
EXP |
Tadalafil inhibits the reaction [Aflatoxin B1 results in increased expression of VEGFA mRNA] |
CTD |
PMID:35608386 |
|
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
|
|
G |
Wnt3a |
Wnt family member 3A |
multiple interactions |
ISO |
Tadalafil inhibits the reaction [Streptozocin results in decreased expression of WNT3A protein] |
CTD |
PMID:34428446 |
|
NCBI chr10:44,034,174...44,078,366
Ensembl chr10:44,034,194...44,078,324
|
|