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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pyrazinopyridoindole
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Accession:CHEBI:48346 term browser browse the term
Synonyms:related_synonym: pyrazinopyridoindoles


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tadalafil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions EXP Tadalafil inhibits the reaction [[Aflatoxin B1 co-treated with Ethanol] results in increased expression of ABCG2 mRNA] CTD PMID:35608386 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions EXP Tadalafil inhibits the reaction [Epinephrine results in decreased expression of ADIPOQ protein] CTD PMID:29233027 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Aif1 allograft inflammatory factor 1 multiple interactions ISO Tadalafil inhibits the reaction [Thioacetamide results in increased expression of AIF1 protein] CTD PMID:31323263 NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP Tadalafil inhibits the reaction [[Aflatoxin B1 co-treated with Ethanol] results in increased expression of AKT1 mRNA] CTD PMID:35608386 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G App amyloid beta precursor protein multiple interactions ISO Tadalafil inhibits the reaction [Streptozocin results in increased expression of APP protein modified form] CTD PMID:34428446 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Sildenafil Citrate promotes the reaction [Tadalafil inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]]; Tadalafil inhibits the reaction [Cisplatin results in increased expression of BAX mRNA]; Tadalafil inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]; Tadalafil promotes the reaction [Sildenafil Citrate inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]]; Testosterone promotes the reaction [Sildenafil Citrate promotes the reaction [Tadalafil inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]]]; Testosterone promotes the reaction [Tadalafil inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]]; Testosterone promotes the reaction [Tadalafil promotes the reaction [Sildenafil Citrate inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]]]; zinc protoporphyrin inhibits the reaction [Tadalafil inhibits the reaction [Cisplatin results in increased expression of BAX mRNA]] CTD PMID:20574430 PMID:32621855 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO
EXP		 Tadalafil inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]
Sildenafil Citrate promotes the reaction [Tadalafil inhibits the reaction [Streptozocin results in decreased expression of BCL2 mRNA]]; Tadalafil inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]; Tadalafil inhibits the reaction [Streptozocin results in decreased expression of BCL2 mRNA]; Tadalafil promotes the reaction [Sildenafil Citrate inhibits the reaction [Streptozocin results in decreased expression of BCL2 mRNA]]; Testosterone promotes the reaction [Sildenafil Citrate promotes the reaction [Tadalafil inhibits the reaction [Streptozocin results in decreased expression of BCL2 mRNA]]]; Testosterone promotes the reaction [Tadalafil inhibits the reaction [Streptozocin results in decreased expression of BCL2 mRNA]]; Testosterone promotes the reaction [Tadalafil promotes the reaction [Sildenafil Citrate inhibits the reaction [Streptozocin results in decreased expression of BCL2 mRNA]]]; zinc protoporphyrin inhibits the reaction [Tadalafil inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]]		 CTD PMID:20543097 PMID:20574430 PMID:32621855 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions ISO Tadalafil inhibits the reaction [Streptozocin results in decreased expression of BDNF protein]; Tadalafil inhibits the reaction [Thioacetamide results in decreased expression of BDNF protein] CTD PMID:31323263 PMID:34428446 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Becn1 beclin 1 multiple interactions ISO Tadalafil inhibits the reaction [Streptozocin results in decreased expression of BECN1 protein modified form] CTD PMID:34428446 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Bmp2 bone morphogenetic protein 2 decreases expression ISO Tadalafil results in decreased expression of BMP2 mRNA CTD PMID:32513693 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP Tadalafil inhibits the reaction [Cisplatin results in increased expression of CASP3 mRNA]; Tadalafil inhibits the reaction [Epinephrine results in increased expression of CASP3 protein]; zinc protoporphyrin inhibits the reaction [Tadalafil inhibits the reaction [Cisplatin results in increased expression of CASP3 mRNA]] CTD PMID:29233027 PMID:32621855 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase multiple interactions EXP Tadalafil inhibits the reaction [Cisplatin results in decreased expression of CAT protein]; zinc protoporphyrin inhibits the reaction [Tadalafil inhibits the reaction [Cisplatin results in decreased expression of CAT protein]] CTD PMID:32621855 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO Tadalafil inhibits the reaction [Streptozocin results in decreased expression of CCND1 mRNA] CTD PMID:34428446 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO Tadalafil inhibits the reaction [Thioacetamide results in decreased phosphorylation of CREB1 protein] CTD PMID:31323263 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO Tadalafil inhibits the reaction [Streptozocin results in increased phosphorylation of CTNNB1 protein] CTD PMID:34428446 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases activity EXP Tadalafil results in increased activity of G6PD protein CTD PMID:24911673 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Gata4 GATA binding protein 4 multiple interactions ISO Tadalafil inhibits the reaction [Doxorubicin results in decreased expression of GATA4 protein] CTD PMID:20543097 NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636 		JBrowse link
G Gcg glucagon decreases activity EXP Tadalafil results in decreased activity of GCG protein CTD PMID:24911673 NCBI chr 3:47,113,914...47,122,958
Ensembl chr 3:47,113,914...47,122,929 		JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO Tadalafil inhibits the reaction [Thioacetamide results in increased expression of GFAP protein] CTD PMID:31323263 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 multiple interactions EXP Tadalafil inhibits the reaction [Aflatoxin B1 results in increased activity of GOT1 protein] CTD PMID:35608386 NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP Tadalafil inhibits the reaction [Aflatoxin B1 results in increased activity of GPT protein] CTD PMID:35608386 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 multiple interactions ISO Tadalafil inhibits the reaction [Thioacetamide results in decreased expression of GRIA1 protein] CTD PMID:31323263 NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283 		JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 multiple interactions ISO Tadalafil inhibits the reaction [Thioacetamide results in decreased expression of GRIA2 protein] CTD PMID:31323263 NCBI chr 2:165,949,379...166,069,510
Ensembl chr 2:165,947,521...166,069,510 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A multiple interactions ISO Tadalafil inhibits the reaction [Thioacetamide results in decreased expression of GRIN2A protein] CTD PMID:31323263 NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO Tadalafil inhibits the reaction [Streptozocin results in decreased phosphorylation of GSK3B protein]; Tadalafil inhibits the reaction [Thioacetamide results in decreased phosphorylation of GSK3B protein] CTD PMID:31323263 PMID:34428446 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions EXP Tadalafil inhibits the reaction [[Aflatoxin B1 co-treated with Ethanol] results in increased expression of HIF1A protein] CTD PMID:35608386 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP Tadalafil promotes the reaction [Cisplatin results in increased expression of HMOX1 mRNA]; Tadalafil promotes the reaction [Cisplatin results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [Tadalafil promotes the reaction [Cisplatin results in increased expression of HMOX1 protein]] CTD PMID:32621855 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression		 EXP
ISO		 Tadalafil inhibits the reaction [Oxygen deficiency results in increased expression of IL1B mRNA]
Tadalafil results in decreased expression of IL1B mRNA
Tadalafil inhibits the reaction [Thioacetamide results in increased expression of IL1B protein]		 CTD PMID:16368379 PMID:31323263 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il23a interleukin 23 subunit alpha multiple interactions ISO Tadalafil inhibits the reaction [Streptozocin results in increased expression of IL23A protein] CTD PMID:34428446 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923 		JBrowse link
G Il27 interleukin 27 multiple interactions ISO Tadalafil inhibits the reaction [Streptozocin results in increased expression of IL27 protein] CTD PMID:34428446 NCBI chr 1:181,173,108...181,178,720
Ensembl chr 1:181,173,372...181,178,582 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Tadalafil inhibits the reaction [Thioacetamide results in increased expression of IL6 protein] CTD PMID:31323263 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ldha lactate dehydrogenase A multiple interactions EXP Tadalafil inhibits the reaction [[Aflatoxin B1 co-treated with Ethanol] results in increased expression of LDHA mRNA] CTD PMID:35608386 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions		 ISO Tadalafil results in increased phosphorylation of MAPK1 protein
Tadalafil inhibits the reaction [Thioacetamide results in increased phosphorylation of MAPK1 protein]		 CTD PMID:18082193 PMID:31323263 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions		 ISO Tadalafil results in increased phosphorylation of MAPK3 protein
Tadalafil inhibits the reaction [Thioacetamide results in increased phosphorylation of MAPK3 protein]		 CTD PMID:18082193 PMID:31323263 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO Tadalafil inhibits the reaction [Streptozocin results in increased expression of MAPT protein modified form] CTD PMID:34428446 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO Tadalafil inhibits the reaction [Streptozocin results in increased expression of MTOR protein modified form] CTD PMID:34428446 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions EXP Tadalafil inhibits the reaction [[Aflatoxin B1 co-treated with Ethanol] results in increased expression of MYC mRNA] CTD PMID:35608386 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP Tadalafil promotes the reaction [Cisplatin results in increased expression of NFE2L2 mRNA] CTD PMID:32621855 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP Tadalafil inhibits the reaction [Cisplatin results in increased expression of NOS2 mRNA]; zinc protoporphyrin inhibits the reaction [Tadalafil inhibits the reaction [Cisplatin results in increased expression of NOS2 mRNA]] CTD PMID:32621855 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Ogn osteoglycin increases expression ISO Tadalafil results in increased expression of OGN mRNA CTD PMID:32513693 NCBI chr17:15,032,069...15,052,626
Ensembl chr17:15,032,069...15,052,739 		JBrowse link
G Pde5a phosphodiesterase 5A decreases activity ISO Tadalafil results in decreased activity of PDE5A protein CTD PMID:15934858 PMID:16368379 PMID:17138653 NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701 		JBrowse link
G Pfkfb3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 multiple interactions EXP Tadalafil inhibits the reaction [[Ethanol co-treated with Aflatoxin B1] results in increased expression of PFKFB3 mRNA] CTD PMID:35608386 NCBI chr17:66,983,629...67,064,702
Ensembl chr17:66,983,686...67,063,125 		JBrowse link
G Ppp2ca protein phosphatase 2 catalytic subunit alpha multiple interactions ISO Tadalafil inhibits the reaction [Streptozocin results in decreased expression of PPP2CA protein modified form] CTD PMID:34428446 NCBI chr10:36,358,110...36,377,864
Ensembl chr10:36,358,101...36,377,862 		JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 multiple interactions ISO [Tadalafil co-treated with Thioacetamide] results in increased expression of PRKG1 protein; Tadalafil inhibits the reaction [Streptozocin results in decreased expression of PRKG1 protein] CTD PMID:31323263 PMID:34428446 NCBI chr 1:228,409,605...229,638,794
Ensembl chr 1:228,408,947...229,639,080 		JBrowse link
G Prkg2 protein kinase cGMP-dependent 2 increases expression ISO Tadalafil results in increased expression of PRKG2 mRNA CTD PMID:32513693 NCBI chr14:10,559,882...10,668,479
Ensembl chr14:10,559,882...10,666,888 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Tadalafil inhibits the reaction [Streptozocin results in increased expression of RELA protein modified form]; Tadalafil inhibits the reaction [Thioacetamide results in increased phosphorylation of RELA protein] CTD PMID:31323263 PMID:34428446 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions EXP Tadalafil inhibits the reaction [Aflatoxin B1 results in increased expression of SLC2A1 mRNA] CTD PMID:35608386 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416 		JBrowse link
G Syp synaptophysin multiple interactions ISO Tadalafil inhibits the reaction [Thioacetamide results in decreased expression of SYP protein] CTD PMID:31323263 NCBI chr  X:14,849,444...14,864,553
Ensembl chr  X:14,849,444...14,864,745 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP Tadalafil inhibits the reaction [[Aflatoxin B1 co-treated with Ethanol] results in increased expression of TGFB1 mRNA] CTD PMID:35608386 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression		 EXP
ISO		 Tadalafil inhibits the reaction [Cisplatin results in increased expression of TNF protein]; Tadalafil inhibits the reaction [Oxygen deficiency results in increased expression of TNF mRNA]; zinc protoporphyrin inhibits the reaction [Tadalafil inhibits the reaction [Cisplatin results in increased expression of TNF protein]]
Tadalafil results in decreased expression of TNF mRNA
Tadalafil inhibits the reaction [Thioacetamide results in increased expression of TNF protein]		 CTD PMID:16368379 PMID:31323263 PMID:32621855 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP Tadalafil inhibits the reaction [Aflatoxin B1 results in increased expression of VEGFA mRNA] CTD PMID:35608386 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Wnt3a Wnt family member 3A multiple interactions ISO Tadalafil inhibits the reaction [Streptozocin results in decreased expression of WNT3A protein] CTD PMID:34428446 NCBI chr10:44,034,174...44,078,366
Ensembl chr10:44,034,194...44,078,324 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    chemical entity 19878
      atom 19878
        nonmetal atom 19800
          nitrogen atom 18979
            nitrogen molecular entity 18979
              organonitrogen compound 18833
                organonitrogen heterocyclic compound 18153
                  pyrazinopyridoindole 52
                    tadalafil 52
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            organic molecule 19706
                              organic cyclic compound 19495
                                organic heterocyclic compound 18874
                                  organic heteropolycyclic compound 18300
                                    organic heterotetracyclic compound 9220
                                      pyrazinopyridoindole 52
                                        tadalafil 52
paths to the root