CHEBI ONTOLOGY - ANNOTATIONS |
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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
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Term: | 1-acetyl-4-(4-\{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy\}phenyl)piperazine |
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Accession: | CHEBI:48339
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browse the term
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Definition: | A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively. |
Synonyms: | related_synonym: | Formula=C26H28Cl2N4O4; InChI=1S/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3; InChIKey=XMAYWYJOQHXEEK-UHFFFAOYSA-N; SMILES=CC(=O)N1CCN(CC1)c1ccc(OCC2COC(Cn3ccnc3)(O2)c2ccc(Cl)cc2Cl)cc1 |
| xref: | Beilstein:634785; DrugBank:DB01026; LINCS:LSM-5148 |
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A2m |
alpha-2-macroglobulin |
decreases expression |
EXP |
Ketoconazole results in decreased expression of A2M mRNA |
CTD |
PMID:18289764 |
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NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786
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Aadat |
aminoadipate aminotransferase |
affects expression |
EXP |
Ketoconazole affects the expression of AADAT mRNA |
CTD |
PMID:18355885 |
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NCBI chr16:29,509,392...29,544,332
Ensembl chr16:29,509,394...29,544,332
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Aamp |
angio-associated, migratory cell protein |
increases expression |
ISO |
Ketoconazole results in increased expression of AAMP mRNA |
CTD |
PMID:36621641 |
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NCBI chr 9:75,863,382...75,869,188
Ensembl chr 9:75,863,389...75,868,547
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Aatf |
apoptosis antagonizing transcription factor |
decreases expression |
EXP |
Ketoconazole results in decreased expression of AATF mRNA |
CTD |
PMID:25787151 |
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NCBI chr10:69,299,029...69,392,207
Ensembl chr10:69,299,037...69,392,201
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Abat |
4-aminobutyrate aminotransferase |
increases expression |
EXP |
Ketoconazole results in increased expression of ABAT mRNA |
CTD |
PMID:37077353 |
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NCBI chr10:6,996,688...7,092,835
Ensembl chr10:6,999,819...7,092,835
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Abca1 |
ATP binding cassette subfamily A member 1 |
multiple interactions decreases expression |
EXP |
Ketoconazole inhibits the reaction [Clofibrate results in increased expression of ABCA1 mRNA] Ketoconazole results in decreased expression of ABCA1 mRNA |
CTD |
PMID:14690017 PMID:37077353 |
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NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
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Abca3 |
ATP binding cassette subfamily A member 3 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of ABCA3 mRNA |
CTD |
PMID:37077353 |
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NCBI chr10:13,382,439...13,439,748
Ensembl chr10:13,382,540...13,439,745
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Abcb11 |
ATP binding cassette subfamily B member 11 |
multiple interactions decreases activity |
ISO |
[Ketoconazole results in decreased activity of ABCB11 protein] which results in decreased export of Taurodeoxycholic Acid; Ketoconazole inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid] |
CTD |
PMID:20147439 PMID:20829430 PMID:23956101 PMID:24014644 PMID:28437613 |
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NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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Abcb1a |
ATP binding cassette subfamily B member 1A |
increases transport multiple interactions decreases activity decreases expression affects expression |
ISO EXP |
ABCB1 protein results in increased transport of Ketoconazole [Ketoconazole binds to and results in decreased activity of ABCB1 protein] which results in decreased export of Digoxin; [Ketoconazole results in decreased activity of ABCB1 protein] which results in increased uptake of Digoxin; Ketoconazole binds to and results in decreased activity of ABCB1 protein; Ketoconazole inhibits the reaction [3,3'-diindolylmethane results in increased expression of ABCB1 mRNA]; Ketoconazole inhibits the reaction [ABCB1 protein affects the transport of Digoxin]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased chemical synthesis of globotriaosylceramide]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased chemical synthesis of Glucosylceramides]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased chemical synthesis of Lactosylceramides]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Ketoconazole inhibits the reaction [Doxorubicin results in increased expression of ABCB1 mRNA]; Ketoconazole inhibits the reaction [Ethanol results in increased expression of ABCB1 mRNA]; Ketoconazole inhibits the reaction [Hydrogen Peroxide affects the expression of ABCB1 mRNA]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [piperine results in increased expression of ABCB1 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [piperine results in increased expression of ABCB1 protein]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of ABCB1 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of ABCB1 protein]]; Ketoconazole inhibits the reaction [Paclitaxel results in increased expression of ABCB1 mRNA]; Ketoconazole inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]; Ketoconazole inhibits the reaction [Rifampin results in increased expression of ABCB1 mRNA]; Ketoconazole inhibits the reaction [Rifampin results in increased expression of ABCB1 protein]; Ketoconazole inhibits the reaction [Spironolactone results in increased expression of ABCB1 protein]; Ketoconazole inhibits the reaction [titanium dioxide results in increased expression of ABCB1 mRNA] Ketoconazole results in decreased expression of ABCB1 mRNA Ketoconazole inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]; Ketoconazole inhibits the reaction [Pregnenolone Carbonitrile results in increased expression of ABCB1 mRNA]; Ketoconazole inhibits the reaction [Pregnenolone Carbonitrile results in increased expression of ABCB1 protein] Ketoconazole affects the expression of ABCB1 mRNA Ketoconazole inhibits the reaction [Genistein results in increased expression of ABCB1A mRNA] Ketoconazole results in decreased expression of ABCB1A mRNA |
CTD |
PMID:10350002 PMID:12235267 PMID:14662772 PMID:15969931 PMID:16819505 PMID:17365992 PMID:18355885 PMID:19070657 PMID:20624464 PMID:21459122 PMID:23707768 PMID:23976943 PMID:25542144 PMID:25844889 PMID:32185415 PMID:33766574 PMID:35478211 PMID:36653537 PMID:36893891 More...
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Abcb4 |
ATP binding cassette subfamily B member 4 |
decreases activity multiple interactions |
ISO EXP |
Ketoconazole results in decreased activity of ABCB4 protein [Chenodeoxycholic Acid co-treated with Ketoconazole] results in increased expression of ABCB4 mRNA |
CTD |
PMID:28437613 PMID:30985903 |
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NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
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Abcc1 |
ATP binding cassette subfamily C member 1 |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [titanium dioxide results in increased expression of ABCC1 mRNA] |
CTD |
PMID:33766574 |
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NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
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Abcc2 |
ATP binding cassette subfamily C member 2 |
decreases activity multiple interactions |
ISO EXP |
Ketoconazole results in decreased activity of ABCC2 protein Ketoconazole inhibits the reaction [Spironolactone results in increased expression of ABCC2 mRNA] |
CTD |
PMID:19070657 PMID:19766108 |
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NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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Abcd2 |
ATP binding cassette subfamily D member 2 |
increases expression |
EXP |
Ketoconazole results in increased expression of ABCD2 mRNA |
CTD |
PMID:36653537 |
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NCBI chr 7:122,263,034...122,311,642
Ensembl chr 7:122,263,032...122,311,642
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Abcg2 |
ATP binding cassette subfamily G member 2 |
multiple interactions increases expression |
EXP |
Ketoconazole inhibits the reaction [Genistein results in increased expression of ABCG2 mRNA] Ketoconazole results in increased expression of ABCG2 mRNA |
CTD |
PMID:32185415 PMID:37077353 |
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NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
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Abracl |
ABRA C-terminal like |
decreases expression |
ISO |
Ketoconazole results in decreased expression of ABRACL mRNA |
CTD |
PMID:36621641 |
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NCBI chr 1:12,654,951...12,665,143
Ensembl chr 1:12,654,838...12,665,207
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Acaa1a |
acetyl-CoA acyltransferase 1A |
increases expression |
EXP |
Ketoconazole results in increased expression of ACAA1 mRNA |
CTD |
PMID:37077353 |
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NCBI chr 8:119,079,401...119,088,626
Ensembl chr 8:119,079,775...119,088,624
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Acaa2 |
acetyl-CoA acyltransferase 2 |
increases expression |
EXP |
Ketoconazole results in increased expression of ACAA2 mRNA |
CTD |
PMID:37077353 |
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NCBI chr18:68,345,136...68,373,246
Ensembl chr18:68,345,012...68,373,249
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Acadl |
acyl-CoA dehydrogenase, long chain |
increases expression |
EXP |
Ketoconazole results in increased expression of ACADL mRNA |
CTD |
PMID:37077353 |
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NCBI chr 9:68,333,981...68,372,149
Ensembl chr 9:68,333,980...68,372,220
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Acadm |
acyl-CoA dehydrogenase medium chain |
increases expression |
EXP |
Ketoconazole results in increased expression of ACADM mRNA |
CTD |
PMID:37077353 |
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NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147
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Acads |
acyl-CoA dehydrogenase short chain |
increases expression |
EXP |
Ketoconazole results in increased expression of ACADS mRNA |
CTD |
PMID:37077353 |
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NCBI chr12:41,493,650...41,502,897
Ensembl chr12:41,493,626...41,502,898
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Ace2 |
angiotensin converting enzyme 2 |
increases expression |
ISO |
Ketoconazole results in increased expression of ACE2 mRNA |
CTD |
PMID:32808185 |
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NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977
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Acot8 |
acyl-CoA thioesterase 8 |
increases expression |
EXP |
Ketoconazole results in increased expression of ACOT8 mRNA |
CTD |
PMID:37077353 |
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NCBI chr 3:153,531,192...153,542,851
Ensembl chr 3:153,531,193...153,542,851
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Acsl4 |
acyl-CoA synthetase long-chain family member 4 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of ACSL4 mRNA |
CTD |
PMID:37077353 |
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NCBI chr X:105,942,794...106,006,573
Ensembl chr X:105,942,799...106,006,427
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Acsl5 |
acyl-CoA synthetase long-chain family member 5 |
increases expression |
EXP |
Ketoconazole results in increased expression of ACSL5 mRNA |
CTD |
PMID:37077353 |
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NCBI chr 1:254,289,513...254,336,608
Ensembl chr 1:254,292,521...254,336,607
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Acsm1 |
acyl-CoA synthetase medium-chain family member 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of ACSM1 mRNA |
CTD |
PMID:28263823 |
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NCBI chr 1:173,985,715...174,020,565
Ensembl chr 1:173,984,672...174,025,495
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Adam9 |
ADAM metallopeptidase domain 9 |
affects expression |
EXP |
Ketoconazole affects the expression of ADAM9 mRNA |
CTD |
PMID:25787151 |
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NCBI chr16:67,022,538...67,101,647
Ensembl chr16:67,022,655...67,100,917
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Adcy6 |
adenylate cyclase 6 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of ADCY6 mRNA |
CTD |
PMID:37077353 |
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NCBI chr 7:129,742,827...129,763,922
Ensembl chr 7:129,742,838...129,763,754
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Adh1c |
alcohol dehydrogenase 1C (class I), gamma polypeptide |
decreases expression |
EXP |
Ketoconazole results in decreased expression of ADH1 mRNA |
CTD |
PMID:36653537 |
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NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892
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Adi1 |
acireductone dioxygenase 1 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of ADI1 mRNA |
CTD |
PMID:36621641 |
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NCBI chr 6:45,306,885...45,313,847
Ensembl chr 6:45,306,841...45,313,842
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Adipoq |
adiponectin, C1Q and collagen domain containing |
increases expression |
EXP |
Ketoconazole results in increased expression of ADIPOQ mRNA |
CTD |
PMID:36653537 |
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NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
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Adipor2 |
adiponectin receptor 2 |
increases expression |
EXP |
Ketoconazole results in increased expression of ADIPOR2 mRNA |
CTD |
PMID:37077353 |
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NCBI chr 4:152,524,604...152,588,848
Ensembl chr 4:152,524,623...152,559,355
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Adora1 |
adenosine A1 receptor |
increases expression |
EXP |
Ketoconazole results in increased expression of ADORA1 mRNA |
CTD |
PMID:37077353 |
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NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801
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Adrb2 |
adrenoceptor beta 2 |
increases expression |
EXP |
Ketoconazole results in increased expression of ADRB2 mRNA |
CTD |
PMID:37077353 |
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NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
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Aebp2 |
AE binding protein 2 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of AEBP2 mRNA |
CTD |
PMID:36621641 |
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NCBI chr 4:173,527,881...173,566,033
Ensembl chr 4:173,528,344...173,593,100
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Agps |
alkylglycerone phosphate synthase |
increases expression |
ISO |
Ketoconazole results in increased expression of AGPS mRNA |
CTD |
PMID:36621641 |
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NCBI chr 3:60,747,323...60,845,831
Ensembl chr 3:60,747,323...60,845,830
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Agrp |
agouti related neuropeptide |
decreases expression |
EXP |
Ketoconazole results in decreased expression of AGRP mRNA |
CTD |
PMID:37077353 |
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NCBI chr19:33,447,992...33,481,602
Ensembl chr19:33,447,992...33,449,584
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Agt |
angiotensinogen |
increases expression |
EXP |
Ketoconazole results in increased expression of AGT mRNA |
CTD |
PMID:37077353 |
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NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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Ahr |
aryl hydrocarbon receptor |
multiple interactions increases activity increases expression |
ISO EXP |
AHR promotes the reaction [Ketoconazole results in increased expression of NQO1 mRNA]; AHR promotes the reaction [Ketoconazole results in increased expression of NQO1 protein]; Ketoconazole inhibits the reaction [Phenobarbital results in increased expression of AHR protein] Ketoconazole inhibits the reaction [Phenobarbital results in increased expression of AHR mRNA]; Ketoconazole inhibits the reaction [Phenobarbital results in increased expression of AHR protein]; Ketoconazole inhibits the reaction [Phenytoin results in increased expression of AHR protein] [Ketoconazole results in increased activity of AHR protein] which results in increased activity of and results in increased localization of NFE2L2 protein; [Ketoconazole results in increased activity of and results in increased localization of AHR protein] which results in increased expression of CYP1A1 mRNA; [Ketoconazole results in increased activity of and results in increased localization of AHR protein] which results in increased expression of CYP1A1 protein; AHR protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]]; AHR protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]]; Ketoconazole results in increased activity of and results in increased localization of AHR protein Ketoconazole results in increased expression of AHR mRNA |
CTD |
PMID:17505019 PMID:17923278 PMID:21753779 PMID:25000292 PMID:31168027 |
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NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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Ahrr |
aryl-hydrocarbon receptor repressor |
multiple interactions increases expression |
EXP |
[Ketoconazole co-treated with Carbon Tetrachloride] results in increased expression of AHRR mRNA Ketoconazole results in increased expression of AHRR mRNA |
CTD |
PMID:31168027 |
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NCBI chr 1:28,993,634...29,088,673
Ensembl chr 1:28,993,634...29,088,673
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Ahsg |
alpha-2-HS-glycoprotein |
increases expression |
EXP |
Ketoconazole results in increased expression of AHSG mRNA |
CTD |
PMID:36653537 |
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NCBI chr11:78,121,388...78,127,998
Ensembl chr11:78,117,918...78,145,999
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Akap12 |
A-kinase anchoring protein 12 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of AKAP12 mRNA |
CTD |
PMID:36621641 |
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NCBI chr 1:40,730,123...40,819,863
Ensembl chr 1:40,730,123...40,819,886
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Akr1b7 |
aldo-keto reductase family 1, member B7 |
increases expression |
EXP |
Ketoconazole results in increased expression of AKR1B7 mRNA |
CTD |
PMID:36653537 |
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NCBI chr 4:63,053,560...63,100,934
Ensembl chr 4:63,076,800...63,089,502
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Akr1c15 |
aldo-keto reductase family 1, member C15 |
increases expression |
EXP |
Ketoconazole results in increased expression of AKR1C15 mRNA |
CTD |
PMID:36653537 |
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NCBI chr17:66,181,493...66,208,090
Ensembl chr17:66,181,493...66,208,061
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Alas1 |
5'-aminolevulinate synthase 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of ALAS1 mRNA |
CTD |
PMID:36653537 |
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NCBI chr 8:106,876,514...106,889,917
Ensembl chr 8:106,876,514...106,889,917
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Alb |
albumin |
affects expression |
EXP |
Ketoconazole affects the expression of ALB mRNA |
CTD |
PMID:36653537 |
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NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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Aldh1a1 |
aldehyde dehydrogenase 1 family, member A1 |
affects expression |
EXP |
Ketoconazole affects the expression of ALDH1A1 mRNA |
CTD |
PMID:18355885 |
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NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
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Aldh7a1 |
aldehyde dehydrogenase 7 family, member A1 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of ALDH7A1 mRNA |
CTD |
PMID:36621641 |
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NCBI chr18:50,003,242...50,042,193
Ensembl chr18:50,009,934...50,042,193
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Alkbh7 |
alkB homolog 7 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of ALKBH7 mRNA |
CTD |
PMID:36653537 |
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NCBI chr 9:1,838,886...1,841,044
Ensembl chr 9:1,838,811...1,841,044
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Alpl |
alkaline phosphatase, biomineralization associated |
multiple interactions increases expression |
ISO |
Ketoconazole inhibits the reaction [Calcifediol results in increased expression of ALPL mRNA] Ketoconazole results in increased expression of ALPL protein |
CTD |
PMID:21542014 PMID:31099283 |
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NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
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Amdhd1 |
amidohydrolase domain containing 1 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of AMDHD1 mRNA |
CTD |
PMID:31099283 |
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NCBI chr 7:28,043,923...28,059,156
Ensembl chr 7:28,043,716...28,059,156
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Amh |
anti-Mullerian hormone |
increases expression |
ISO |
Ketoconazole results in increased expression of AMH protein |
CTD |
PMID:16684832 |
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NCBI chr 7:8,906,776...8,909,192
Ensembl chr 7:8,906,836...8,909,282
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Ang |
angiogenin |
increases expression |
ISO |
Ketoconazole results in increased expression of ANG mRNA |
CTD |
PMID:36621641 |
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NCBI chr15:24,312,711...24,323,361
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Anxa1 |
annexin A1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of ANXA1 mRNA |
CTD |
PMID:25787151 |
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NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
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Aox1 |
aldehyde oxidase 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of AOX1 mRNA |
CTD |
PMID:36653537 |
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NCBI chr 9:59,579,621...59,658,772
Ensembl chr 9:59,579,649...59,658,770
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Ap1s1 |
adaptor related protein complex 1 subunit sigma 1 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of AP1S1 mRNA |
CTD |
PMID:17175557 |
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NCBI chr12:19,625,267...19,635,792
Ensembl chr12:19,625,332...19,756,713
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Ap3m1 |
adaptor related protein complex 3 subunit mu 1 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of AP3M1 mRNA |
CTD |
PMID:36621641 |
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NCBI chr15:3,246,616...3,264,846
Ensembl chr15:3,246,926...3,264,844
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Apaf1 |
apoptotic peptidase activating factor 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of APAF1 mRNA |
CTD |
PMID:37077353 |
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NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
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Apoa1 |
apolipoprotein A1 |
increases expression |
EXP |
Ketoconazole results in increased expression of APOA1 mRNA |
CTD |
PMID:36653537 |
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NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
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Apoa4 |
apolipoprotein A4 |
affects expression |
EXP |
Ketoconazole affects the expression of APOA4 mRNA |
CTD |
PMID:18355885 |
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NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469
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Apoe |
apolipoprotein E |
increases expression |
EXP |
Ketoconazole results in increased expression of APOE mRNA |
CTD |
PMID:37077353 |
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NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
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G |
Ar |
androgen receptor |
multiple interactions decreases activity increases activity decreases expression |
ISO EXP |
[Goserelin co-treated with Dutasteride co-treated with bicalutamide co-treated with Ketoconazole] results in decreased expression of AR protein; Ketoconazole inhibits the reaction [Metribolone results in increased activity of AR protein]; Ketoconazole inhibits the reaction [Stanozolol binds to and results in increased activity of AR protein] Ketoconazole results in decreased activity of AR protein Ketoconazole results in increased activity of AR protein Ketoconazole results in decreased expression of AR protein Ketoconazole inhibits the reaction [Phenytoin results in increased expression of AR protein] |
CTD |
PMID:11118046 PMID:18324785 PMID:19226368 PMID:19587329 PMID:24323034 PMID:26867867 PMID:29162470 More...
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NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Arg1 |
arginase 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of ARG1 mRNA |
CTD |
PMID:37077353 |
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NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
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Asb17 |
ankyrin repeat and SOCS box-containing 17 |
increases expression |
ISO |
Ketoconazole results in increased expression of ASB17 mRNA |
CTD |
PMID:31099283 |
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NCBI chr 2:242,775,887...242,786,950
Ensembl chr 2:242,775,994...242,786,903
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G |
Asns |
asparagine synthetase (glutamine-hydrolyzing) |
increases expression |
ISO |
Ketoconazole results in increased expression of ASNS mRNA |
CTD |
PMID:15342952 PMID:17175557 |
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NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423
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G |
Ass1 |
argininosuccinate synthase 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of ASS1 mRNA |
CTD |
PMID:36653537 |
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NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903
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G |
Atad2 |
ATPase family, AAA domain containing 2 |
increases expression |
ISO |
Ketoconazole results in increased expression of ATAD2 mRNA |
CTD |
PMID:36621641 |
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NCBI chr 7:89,634,123...89,676,738
Ensembl chr 7:89,634,123...89,676,738
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G |
Atf1 |
activating transcription factor 1 |
multiple interactions |
ISO |
Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [Dinoprostone results in increased phosphorylation of ATF1 protein]]; Ketoconazole inhibits the reaction [Dinoprostone promotes the reaction [ATF1 protein modified form binds to PTGS2 promoter]]; Ketoconazole inhibits the reaction [Dinoprostone results in increased phosphorylation of ATF1 protein] |
CTD |
PMID:12164941 |
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NCBI chr 7:131,361,962...131,404,677
Ensembl chr 7:131,362,450...131,404,670
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G |
Atp5mc2 |
ATP synthase membrane subunit c locus 2 |
increases expression |
ISO |
Ketoconazole results in increased expression of ATP5MC2 mRNA |
CTD |
PMID:36621641 |
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NCBI chr 7:133,791,341...133,799,713
Ensembl chr 7:133,791,342...133,799,733
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G |
Atp5po |
ATP synthase peripheral stalk subunit OSCP |
increases expression |
EXP |
Ketoconazole results in increased expression of ATP5PO mRNA |
CTD |
PMID:37077353 |
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NCBI chr11:31,165,218...31,171,530
Ensembl chr11:31,165,217...31,171,592
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G |
Atp6v1d |
ATPase H+ transporting V1 subunit D |
increases expression |
EXP |
Ketoconazole results in increased expression of ATP6V1D mRNA |
CTD |
PMID:37077353 |
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NCBI chr 6:97,656,725...97,672,295
Ensembl chr 6:97,656,576...97,672,303
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G |
Avp |
arginine vasopressin |
increases expression |
EXP |
Ketoconazole results in increased expression of AVP mRNA |
CTD |
PMID:37077353 |
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NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425
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G |
Bace1 |
beta-secretase 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of BACE1 mRNA |
CTD |
PMID:37077353 |
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NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876
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G |
Bad |
BCL2-associated agonist of cell death |
increases expression |
EXP |
Ketoconazole results in increased expression of BAD mRNA |
CTD |
PMID:25787151 |
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NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
ISO |
[Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in increased expression of BAX protein; Ketoconazole inhibits the reaction [Calcifediol results in decreased expression of BAX mRNA] |
CTD |
PMID:21542014 PMID:31629065 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
ISO |
[Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of BCL2 protein; Ketoconazole inhibits the reaction [Calcifediol results in increased expression of BCL2 mRNA] |
CTD |
PMID:21542014 PMID:31629065 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bcl2l11 |
Bcl2-like 11 |
increases expression |
ISO |
Ketoconazole results in increased expression of BCL2L11 mRNA |
CTD |
PMID:25808816 |
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NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
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G |
Becn1 |
beclin 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of BECN1 mRNA |
CTD |
PMID:37077353 |
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NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
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G |
Bhmt |
betaine-homocysteine S-methyltransferase |
affects expression |
EXP |
Ketoconazole affects the expression of BHMT mRNA |
CTD |
PMID:18355885 |
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NCBI chr 2:24,859,871...24,879,449
Ensembl chr 2:24,859,873...24,879,742
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G |
Bicc1 |
BicC family RNA binding protein 1 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of BICC1 mRNA |
CTD |
PMID:31099283 |
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NCBI chr20:17,449,639...17,686,775
Ensembl chr20:17,449,560...17,686,776
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G |
Bid |
BH3 interacting domain death agonist |
increases expression |
ISO |
Ketoconazole results in increased expression of BID mRNA |
CTD |
PMID:25808816 |
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NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
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G |
Bin1 |
bridging integrator 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of BIN1 mRNA |
CTD |
PMID:37077353 |
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NCBI chr18:24,009,731...24,067,267
Ensembl chr18:24,009,653...24,067,263
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G |
Birc5 |
baculoviral IAP repeat-containing 5 |
increases expression |
EXP |
Ketoconazole results in increased expression of BIRC5 mRNA |
CTD |
PMID:37077353 |
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NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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G |
Bmp2 |
bone morphogenetic protein 2 |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [menatetrenone promotes the reaction [Phosphates results in increased expression of BMP2 mRNA]]; Ketoconazole inhibits the reaction [Phosphates promotes the reaction [menatetrenone results in increased expression of BMP2 mRNA]] |
CTD |
PMID:31843813 |
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NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
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G |
Bmp4 |
bone morphogenetic protein 4 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of BMP4 mRNA |
CTD |
PMID:36653537 |
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NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306
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G |
Bmp6 |
bone morphogenetic protein 6 |
increases expression |
ISO |
Ketoconazole results in increased expression of BMP6 mRNA |
CTD |
PMID:32816093 |
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NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365
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G |
Bnc1 |
basonuclin zinc finger protein 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of BNC1 mRNA |
CTD |
PMID:36653537 |
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NCBI chr 1:135,917,676...135,943,333
Ensembl chr 1:135,917,687...135,943,333
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G |
Bnip1 |
BCL2 interacting protein 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of BNIP1 mRNA |
CTD |
PMID:25808816 |
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NCBI chr10:16,386,876...16,399,124
Ensembl chr10:16,386,841...16,399,157
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G |
Bnip2 |
BCL2 interacting protein 2 |
increases expression |
EXP |
Ketoconazole results in increased expression of BNIP2 mRNA |
CTD |
PMID:25808816 |
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NCBI chr 8:70,640,436...70,661,782
Ensembl chr 8:70,640,445...70,675,590
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G |
Bnip3 |
BCL2 interacting protein 3 |
increases expression |
EXP |
Ketoconazole results in increased expression of BNIP3 mRNA |
CTD |
PMID:25808816 |
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NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
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G |
Bnip3l |
BCL2 interacting protein 3 like |
decreases expression |
ISO |
Ketoconazole results in decreased expression of BNIP3L mRNA |
CTD |
PMID:36621641 |
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NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803
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G |
C10h5orf15 |
similar to human chromosome 5 open reading frame 15 |
increases expression |
ISO |
Ketoconazole results in increased expression of C5ORF15 mRNA |
CTD |
PMID:36621641 |
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NCBI chr10:36,563,989...36,576,593
Ensembl chr10:36,563,958...36,576,590
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G |
C1galt1 |
core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of C1GALT1 mRNA |
CTD |
PMID:36621641 |
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NCBI chr 4:35,930,981...35,966,100
Ensembl chr 4:35,928,104...35,961,831
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G |
C1galt1c1 |
C1GALT1-specific chaperone 1 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of C1GALT1C1 mRNA |
CTD |
PMID:36621641 |
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NCBI chr X:117,378,123...117,382,620
Ensembl chr X:117,375,525...117,382,787
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G |
C3 |
complement C3 |
increases expression |
EXP |
Ketoconazole results in increased expression of C3 mRNA |
CTD |
PMID:37077353 |
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NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
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G |
C5h1orf174 |
similar to human chromosome 1 open reading frame 174 |
increases expression |
ISO |
Ketoconazole results in increased expression of C1ORF174 mRNA |
CTD |
PMID:36621641 |
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NCBI chr 5:164,515,578...164,520,022
Ensembl chr 5:164,515,559...164,520,021
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G |
Cacna1h |
calcium voltage-gated channel subunit alpha1 H |
decreases expression |
EXP |
Ketoconazole results in decreased expression of CACNA1H mRNA |
CTD |
PMID:37077353 |
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NCBI chr10:14,390,104...14,448,204
Ensembl chr10:14,390,113...14,448,376
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G |
Cacna1i |
calcium voltage-gated channel subunit alpha1 I |
decreases expression |
EXP |
Ketoconazole results in decreased expression of CACNA1I mRNA |
CTD |
PMID:37077353 |
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NCBI chr 7:111,835,996...111,947,418
Ensembl chr 7:111,836,012...111,944,688
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G |
Cacna2d3 |
calcium voltage-gated channel auxiliary subunit alpha2delta 3 |
increases expression |
EXP |
Ketoconazole results in increased expression of CACNA2D3 mRNA |
CTD |
PMID:37077353 |
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NCBI chr16:4,098,439...4,912,498
Ensembl chr16:4,098,445...4,912,351
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G |
Cacna2d4 |
calcium voltage-gated channel auxiliary subunit alpha2delta 4 |
increases expression |
EXP |
Ketoconazole results in increased expression of CACNA2D4 mRNA |
CTD |
PMID:37077353 |
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NCBI chr 4:152,408,588...152,521,478
Ensembl chr 4:152,408,657...152,521,268
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G |
Cacnb1 |
calcium voltage-gated channel auxiliary subunit beta 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of CACNB1 mRNA |
CTD |
PMID:37077353 |
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NCBI chr10:82,998,182...83,018,838
Ensembl chr10:82,998,182...83,018,694
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G |
Cacng3 |
calcium voltage-gated channel auxiliary subunit gamma 3 |
increases expression |
EXP |
Ketoconazole results in increased expression of CACNG3 mRNA |
CTD |
PMID:37077353 |
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NCBI chr 1:177,201,361...177,297,019
Ensembl chr 1:177,201,288...177,297,024
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G |
Cacng4 |
calcium voltage-gated channel auxiliary subunit gamma 4 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of CACNG4 mRNA |
CTD |
PMID:37077353 |
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NCBI chr10:92,683,778...92,745,842
Ensembl chr10:92,683,761...92,746,126
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G |
Calb1 |
calbindin 1 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of CALB1 mRNA |
CTD |
PMID:31099283 |
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NCBI chr 5:29,375,624...29,402,532
Ensembl chr 5:29,375,642...29,402,431
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G |
Calb2 |
calbindin 2 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of CALB2 mRNA |
CTD |
PMID:36653537 |
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NCBI chr19:38,114,435...38,141,438
Ensembl chr19:38,114,424...38,141,438
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G |
Cap1 |
cyclase associated actin cytoskeleton regulatory protein 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of CAP1 mRNA |
CTD |
PMID:36653537 |
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NCBI chr 5:135,142,108...135,168,885
Ensembl chr 5:135,142,112...135,168,769
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G |
Car2 |
carbonic anhydrase 2 |
increases expression |
EXP |
Ketoconazole results in increased expression of CA2 mRNA; Ketoconazole results in increased expression of CAR2 mRNA |
CTD |
PMID:37077353 |
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NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
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G |
Carmil1 |
capping protein regulator and myosin 1 linker 1 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of CARMIL1 mRNA |
CTD |
PMID:36621641 |
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NCBI chr17:40,807,921...41,088,326
Ensembl chr17:40,808,389...41,088,326
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G |
Casp12 |
caspase 12 |
increases expression |
ISO |
Ketoconazole results in increased expression of CASP12 mRNA |
CTD |
PMID:25808816 |
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NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
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G |
Casp3 |
caspase 3 |
increases activity multiple interactions |
ISO |
Ketoconazole results in increased activity of CASP3 protein Ketoconazole inhibits the reaction [Galactosamine results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [Ketoconazole results in increased activity of CASP3 protein] |
CTD |
PMID:17936189 PMID:19631732 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp6 |
caspase 6 |
decreases expression increases expression |
EXP |
Ketoconazole results in decreased expression of CASP6 mRNA Ketoconazole results in increased expression of CASP6 mRNA |
CTD |
PMID:25787151 PMID:25808816 |
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NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
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G |
Casp7 |
caspase 7 |
increases expression |
EXP |
Ketoconazole results in increased expression of CASP7 mRNA |
CTD |
PMID:25808816 |
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NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
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G |
Casp8ap2 |
caspase 8 associated protein 2 |
affects expression |
ISO |
Ketoconazole affects the expression of CASP8AP2 mRNA |
CTD |
PMID:36621641 |
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NCBI chr 5:47,014,501...47,052,276
Ensembl chr 5:47,014,667...47,052,275
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G |
Casp9 |
caspase 9 |
increases expression |
ISO |
Ketoconazole results in increased expression of CASP9 mRNA |
CTD |
PMID:25808816 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Cat |
catalase |
decreases expression |
EXP |
Ketoconazole results in decreased expression of CAT mRNA |
CTD |
PMID:25787151 |
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Cav1 |
caveolin 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of CAV1 mRNA |
CTD |
PMID:36621641 |
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NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
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G |
Cbx7 |
chromobox 7 |
increases expression |
EXP |
Ketoconazole results in increased expression of CBX7 mRNA |
CTD |
PMID:37077353 |
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NCBI chr 7:111,460,656...111,479,231
Ensembl chr 7:111,460,656...111,477,973
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G |
Ccdc8 |
coiled-coil domain containing 8 |
increases expression |
EXP |
Ketoconazole results in increased expression of CCDC8 mRNA |
CTD |
PMID:36653537 |
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NCBI chr 1:77,679,521...77,682,849
Ensembl chr 1:77,679,218...77,683,090
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G |
Cck |
cholecystokinin |
increases expression |
EXP |
Ketoconazole results in increased expression of CCK mRNA |
CTD |
PMID:37077353 |
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NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions increases expression |
ISO EXP |
Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]; PTGER2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; PTGER3 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]] Ketoconazole results in increased expression of CCL2 mRNA |
CTD |
PMID:16784723 PMID:37077353 |
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NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Ccl27 |
C-C motif chemokine ligand 27 |
multiple interactions |
ISO |
Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 mRNA]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 mRNA]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]; PTGER2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; PTGER3 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]] |
CTD |
PMID:16784723 |
|
NCBI chr 5:56,941,402...56,948,511
Ensembl chr 5:56,941,402...56,948,506
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G |
Ccl5 |
C-C motif chemokine ligand 5 |
multiple interactions increases expression |
ISO EXP |
Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]; PTGER2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]; PTGER3 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]] Ketoconazole results in increased expression of CCL5 mRNA |
CTD |
PMID:16784723 PMID:23688403 PMID:37077353 |
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NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
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G |
Ccn1 |
cellular communication network factor 1 |
increases expression affects expression |
ISO EXP |
Ketoconazole results in increased expression of CCN1 mRNA Ketoconazole affects the expression of CCN1 mRNA |
CTD |
PMID:36621641 PMID:36653537 |
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NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484
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G |
Ccng1 |
cyclin G1 |
increases expression |
EXP |
Ketoconazole results in increased expression of CCNG1 mRNA |
CTD |
PMID:18289764 |
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NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641
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G |
Cd200 |
Cd200 molecule |
increases expression |
ISO |
Ketoconazole results in increased expression of CD200 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr11:55,410,166...55,437,527
Ensembl chr11:55,410,196...55,501,648
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G |
Cd247 |
Cd247 molecule |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased abundance of Calcitriol]; Ketoconazole inhibits the reaction [Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]] |
CTD |
PMID:24792400 |
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NCBI chr13:78,043,302...78,118,437
Ensembl chr13:78,043,307...78,122,263
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G |
Cd274 |
CD274 molecule |
decreases expression |
EXP |
Ketoconazole results in decreased expression of CD274 mRNA |
CTD |
PMID:37077353 |
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NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:227,116,649...227,134,450
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G |
Cd28 |
Cd28 molecule |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased abundance of Calcitriol]; Ketoconazole inhibits the reaction [Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]] |
CTD |
PMID:24792400 |
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NCBI chr 9:62,166,324...62,194,674
Ensembl chr 9:62,166,192...62,194,685
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G |
Cd3d |
CD3 delta subunit of T-cell receptor complex |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased abundance of Calcitriol]; Ketoconazole inhibits the reaction [Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]] |
CTD |
PMID:24792400 |
|
NCBI chr 8:45,287,803...45,293,342
Ensembl chr 8:45,288,749...45,301,809
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G |
Cd3e |
CD3 epsilon subunit of T-cell receptor complex |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased abundance of Calcitriol]; Ketoconazole inhibits the reaction [Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]] |
CTD |
PMID:24792400 |
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NCBI chr 8:45,303,848...45,315,005
Ensembl chr 8:45,303,852...45,315,022
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G |
Cd3g |
CD3 gamma subunit of T-cell receptor complex |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased abundance of Calcitriol]; Ketoconazole inhibits the reaction [Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]] |
CTD |
PMID:24792400 |
|
NCBI chr 8:45,280,797...45,287,271
Ensembl chr 8:45,281,204...45,287,147
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G |
Cd47 |
Cd47 molecule |
increases expression |
ISO |
Ketoconazole results in increased expression of CD47 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr11:50,906,052...50,970,000
Ensembl chr11:50,906,177...50,969,425
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G |
Cdc42ep2 |
CDC42 effector protein 2 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of CDC42EP2 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr 1:203,202,000...203,210,891
Ensembl chr 1:203,201,873...203,210,897
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G |
Cdc42ep3 |
CDC42 effector protein 3 |
increases expression |
EXP |
Ketoconazole results in increased expression of CDC42EP3 mRNA |
CTD |
PMID:28263823 |
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NCBI chr 6:15,710,894...15,731,366
Ensembl chr 6:15,708,730...15,732,721
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G |
Cdk2 |
cyclin dependent kinase 2 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of CDK2 mRNA |
CTD |
PMID:37077353 |
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NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
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G |
Cdk6 |
cyclin-dependent kinase 6 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of CDK6 mRNA |
CTD |
PMID:37077353 |
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NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression |
ISO EXP |
Ketoconazole results in increased expression of CDKN1A mRNA |
CTD |
PMID:16483768 PMID:25808816 PMID:37077353 |
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NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Cdkn1b |
cyclin-dependent kinase inhibitor 1B |
increases expression |
EXP |
Ketoconazole results in increased expression of CDKN1B mRNA |
CTD |
PMID:25808816 |
|
NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
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G |
Cdkn2c |
cyclin-dependent kinase inhibitor 2C |
affects expression |
EXP |
Ketoconazole affects the expression of CDKN2C mRNA |
CTD |
PMID:18355885 |
|
NCBI chr 5:124,411,123...124,416,278
Ensembl chr 5:124,411,124...124,416,278
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G |
Cebpa |
CCAAT/enhancer binding protein alpha |
increases expression |
EXP |
Ketoconazole results in increased expression of CEBPA mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
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G |
Cenpu |
centromere protein U |
decreases expression |
ISO |
Ketoconazole results in decreased expression of CENPU mRNA |
CTD |
PMID:36621641 |
|
NCBI chr16:45,715,821...45,739,038
Ensembl chr16:45,714,294...45,738,823
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G |
Cep15 |
centrosomal protein 15 |
increases expression |
ISO |
Ketoconazole results in increased expression of CEP15 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr15:12,815,159...12,835,115
Ensembl chr15:12,818,385...12,833,838
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G |
Cep19 |
centrosomal protein 19 |
increases expression |
ISO |
Ketoconazole results in increased expression of CEP19 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr11:68,677,869...68,687,117
Ensembl chr11:68,677,871...68,687,022
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G |
Ces2h |
carboxylesterase 2H |
affects expression |
EXP |
Ketoconazole affects the expression of CES2 mRNA |
CTD |
PMID:18355885 |
|
NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
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G |
Cfb |
complement factor B |
increases expression |
EXP |
Ketoconazole results in increased expression of CFB mRNA |
CTD |
PMID:36653537 |
|
NCBI chr20:3,970,643...3,976,510
Ensembl chr20:3,951,474...3,976,505
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G |
Cga |
glycoprotein hormones, alpha polypeptide |
decreases expression |
ISO |
Ketoconazole results in decreased expression of CGA mRNA |
CTD |
PMID:25808816 |
|
NCBI chr 5:49,486,915...49,499,192
Ensembl chr 5:49,487,068...49,499,191
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G |
Chrac1 |
chromatin accessibility complex subunit 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of CHRAC1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 7:105,013,047...105,016,435
Ensembl chr 7:105,013,015...105,017,136
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G |
Cibar1 |
CBY1 interacting BAR domain containing 1 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of CIBAR1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 5:25,613,993...25,632,440
Ensembl chr 5:25,614,033...25,632,489
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G |
Cidea |
cell death-inducing DFFA-like effector a |
increases expression |
EXP |
Ketoconazole results in increased expression of CIDEA mRNA |
CTD |
PMID:36653537 PMID:37077353 |
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NCBI chr18:60,894,917...60,920,485
Ensembl chr18:60,894,874...60,920,481
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G |
Ckap2l |
cytoskeleton associated protein 2-like |
decreases expression |
ISO |
Ketoconazole results in decreased expression of CKAP2L mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 3:116,497,186...116,524,302
Ensembl chr 3:116,498,022...116,524,366
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G |
Clcf1 |
cardiotrophin-like cytokine factor 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of CLCF1 mRNA |
CTD |
PMID:31099283 |
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NCBI chr 1:201,507,763...201,517,607
Ensembl chr 1:201,507,859...201,517,605
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G |
Clec4e |
C-type lectin domain family 4, member E |
increases expression |
ISO |
Ketoconazole results in increased expression of CLEC4E mRNA |
CTD |
PMID:31099283 |
|
NCBI chr 4:156,606,927...156,612,911
Ensembl chr 4:156,607,614...156,612,767
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G |
Clmn |
calmin |
multiple interactions |
ISO |
Ketoconazole promotes the reaction [Calcitriol results in increased expression of CLMN mRNA] |
CTD |
PMID:26485663 |
|
NCBI chr 6:123,707,710...123,807,283
Ensembl chr 6:123,713,507...123,807,272
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G |
Cln5 |
CLN5, intracellular trafficking protein |
affects expression |
ISO |
Ketoconazole affects the expression of CLN5 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr15:79,893,573...79,903,438
Ensembl chr15:79,893,548...79,903,438
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G |
Clu |
clusterin |
affects expression decreases expression |
EXP |
Ketoconazole affects the expression of CLU mRNA Ketoconazole results in decreased expression of CLU mRNA |
CTD |
PMID:17558187 PMID:18289764 |
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NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
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G |
Cmtm6 |
CKLF-like MARVEL transmembrane domain containing 6 |
affects expression |
EXP |
Ketoconazole affects the expression of CMTM6 mRNA |
CTD |
PMID:18355885 |
|
NCBI chr 8:114,422,934...114,441,034
Ensembl chr 8:114,422,921...114,441,033
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G |
Cmtm7 |
CKLF-like MARVEL transmembrane domain containing 7 |
increases expression |
ISO |
Ketoconazole results in increased expression of CMTM7 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 8:114,448,037...114,474,958
Ensembl chr 8:114,448,042...114,474,621
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G |
Cnr2 |
cannabinoid receptor 2 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of CNR2 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr 5:148,125,222...148,151,548
Ensembl chr 5:148,125,604...148,151,548
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G |
Col1a1 |
collagen type I alpha 1 chain |
decreases expression |
EXP |
Ketoconazole results in decreased expression of COL1A1 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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G |
Commd2 |
COMM domain containing 2 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of COMMD2 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 2:141,848,661...141,852,907
Ensembl chr 2:141,848,680...141,852,888
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G |
Cop1 |
COP1, E3 ubiquitin ligase |
decreases expression |
ISO |
Ketoconazole results in decreased expression of COP1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr13:71,467,164...71,561,826
Ensembl chr13:71,429,961...71,538,890
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G |
Copz1 |
COPI coat complex subunit zeta 1 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of COPZ1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 7:134,409,523...134,435,661
Ensembl chr 7:134,409,799...134,435,662
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G |
Cox18 |
cytochrome c oxidase assembly factor COX18 |
affects expression |
ISO |
Ketoconazole affects the expression of COX18 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr14:17,864,581...17,877,483
Ensembl chr14:17,865,857...17,877,480
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G |
Cpn2 |
carboxypeptidase N subunit 2 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of CPN2 mRNA |
CTD |
PMID:31099283 |
|
NCBI chr11:70,486,054...70,495,937
Ensembl chr11:70,486,057...70,496,472
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G |
Cpped1 |
calcineurin-like phosphoesterase domain containing 1 |
affects expression |
EXP |
Ketoconazole affects the expression of CPPED1 mRNA |
CTD |
PMID:18355885 |
|
NCBI chr10:3,701,522...3,821,050
Ensembl chr10:3,701,459...3,821,054
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G |
Cpt1b |
carnitine palmitoyltransferase 1B |
decreases expression |
EXP |
Ketoconazole results in decreased expression of CPT1B mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 7:120,491,354...120,500,833
Ensembl chr 7:120,491,354...120,500,404
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G |
Cpt2 |
carnitine palmitoyltransferase 2 |
increases expression |
EXP |
Ketoconazole results in increased expression of CPT2 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095
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G |
Cr2 |
complement C3d receptor 2 |
increases expression |
EXP |
Ketoconazole results in increased expression of CR2 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr13:106,678,579...106,716,595
Ensembl chr13:106,685,413...106,716,235
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G |
Creb1 |
cAMP responsive element binding protein 1 |
multiple interactions decreases expression |
ISO EXP |
Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [Dinoprostone results in increased phosphorylation of CREB1 protein]]; Ketoconazole inhibits the reaction [Dinoprostone promotes the reaction [CREB1 protein modified form binds to PTGS2 promoter]]; Ketoconazole inhibits the reaction [Dinoprostone results in increased phosphorylation of CREB1 protein] Ketoconazole inhibits the reaction [Arachidonic Acid results in increased phosphorylation of CREB1 protein]; Ketoconazole inhibits the reaction [Epinephrine results in increased phosphorylation of CREB1 protein] Ketoconazole results in decreased expression of CREB1 mRNA |
CTD |
PMID:12164941 PMID:17680988 PMID:37077353 |
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NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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G |
Crem |
cAMP responsive element modulator |
affects expression decreases expression |
EXP |
Ketoconazole affects the expression of CREM mRNA Ketoconazole results in decreased expression of CREM mRNA |
CTD |
PMID:18355885 PMID:36653537 |
|
NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989
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G |
Crhr2 |
corticotropin releasing hormone receptor 2 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of CRHR2 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 4:84,222,897...84,265,924
Ensembl chr 4:84,224,002...84,265,904
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G |
Crls1 |
cardiolipin synthase 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of CRLS1 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr 3:120,119,822...120,138,674
Ensembl chr 3:120,119,852...120,138,655
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G |
Crym |
crystallin, mu |
decreases expression |
EXP |
Ketoconazole results in decreased expression of CRYM mRNA |
CTD |
PMID:36653537 |
|
NCBI chr 1:174,560,423...174,575,660
Ensembl chr 1:174,560,416...174,575,633
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G |
Ctnnb1 |
catenin beta 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of CTNNB1 mRNA |
CTD |
PMID:37077353 |
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NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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G |
Ctsl |
cathepsin L |
decreases expression |
ISO |
Ketoconazole results in decreased expression of CTSL mRNA |
CTD |
PMID:36621641 |
|
NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548
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G |
Ctss |
cathepsin S |
affects expression |
EXP |
Ketoconazole affects the expression of CTSS mRNA |
CTD |
PMID:18289764 |
|
NCBI chr 2:183,086,437...183,114,483
Ensembl chr 2:183,086,437...183,114,483
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G |
Cxcl10 |
C-X-C motif chemokine ligand 10 |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [Biological Products results in increased expression of CXCL10 mRNA]; Ketoconazole inhibits the reaction [Biological Products results in increased expression of CXCL10 protein] |
CTD |
PMID:24471457 |
|
NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
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G |
Cxcl14 |
C-X-C motif chemokine ligand 14 |
increases expression |
EXP |
Ketoconazole results in increased expression of CXCL14 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr17:8,317,930...8,325,956
Ensembl chr17:8,317,933...8,324,839
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G |
Cyba |
cytochrome b-245 alpha chain |
increases expression |
EXP |
Ketoconazole results in increased expression of CYBA mRNA |
CTD |
PMID:37077353 |
|
NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721
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G |
Cycs |
cytochrome c, somatic |
decreases expression increases expression |
EXP |
Ketoconazole results in decreased expression of CYCS mRNA Ketoconazole results in increased expression of CYCS mRNA |
CTD |
PMID:25787151 PMID:37077353 |
|
NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
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G |
Cyct |
cytochrome c, testis |
increases expression |
EXP |
Ketoconazole results in increased expression of CYCT mRNA |
CTD |
PMID:25787151 |
|
NCBI chr 3:61,290,090...61,297,158
Ensembl chr 3:60,913,562...61,297,158
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G |
Cyp11a1 |
cytochrome P450, family 11, subfamily a, polypeptide 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of CYP11A1 mRNA |
CTD |
PMID:26610754 |
|
NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
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G |
Cyp11b2 |
cytochrome P450, family 11, subfamily b, polypeptide 2 |
multiple interactions decreases activity |
ISO |
Ketoconazole binds to and results in decreased activity of CYP11B1 protein Ketoconazole results in decreased activity of CYP11B1 protein |
CTD |
PMID:15743198 PMID:31982514 |
|
NCBI chr 7:106,838,590...106,845,004
Ensembl chr 7:106,838,590...106,845,004
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G |
Cyp11b3 |
cytochrome P450, family 11, subfamily b, polypeptide 3 |
decreases activity increases expression multiple interactions |
ISO |
Ketoconazole results in decreased activity of CYP11B2 protein Ketoconazole results in increased expression of CYP11B2 mRNA Ketoconazole binds to and results in decreased activity of CYP11B2 protein; Ketoconazole promotes the reaction [Colforsin results in increased expression of CYP11B2 mRNA] |
CTD |
PMID:15743198 PMID:16935330 PMID:31982514 |
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NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048
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G |
Cyp17a1 |
cytochrome P450, family 17, subfamily a, polypeptide 1 |
decreases activity multiple interactions decreases expression |
ISO EXP |
Ketoconazole results in decreased activity of CYP17A1 protein Ketoconazole inhibits the reaction [Colforsin results in increased expression of CYP17A1 mRNA] Ketoconazole results in decreased expression of CYP17A1 mRNA |
CTD |
PMID:11118046 PMID:15743198 PMID:15771425 PMID:15934942 PMID:16935330 PMID:25993309 PMID:31330226 PMID:31982514 PMID:36653537 More...
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NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
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G |
Cyp19a1 |
cytochrome P450, family 19, subfamily a, polypeptide 1 |
increases activity decreases activity multiple interactions decreases expression |
ISO EXP |
Ketoconazole results in increased activity of CYP19A1 protein Ketoconazole results in decreased activity of CYP19A1 protein [Ketoconazole results in increased activity of CYP19A1 protein] which results in increased chemical synthesis of Estrone; [Ketoconazole results in increased activity of CYP19A1 protein] which results in increased metabolism of Androstenedione Ketoconazole results in decreased expression of CYP19A1 mRNA |
CTD |
PMID:20087668 PMID:27159630 PMID:31330226 PMID:36374910 PMID:36653537 |
|
NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases activity multiple interactions decreases activity increases expression |
ISO EXP |
Ketoconazole results in increased activity of CYP1A1 protein [Ketoconazole co-treated with Carbon Tetrachloride] results in increased expression of CYP1A1 mRNA; Ketoconazole inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] Ketoconazole results in decreased activity of CYP1A1 protein [Ketoconazole results in increased activity of and results in increased localization of AHR protein] which results in increased expression of CYP1A1 mRNA; [Ketoconazole results in increased activity of and results in increased localization of AHR protein] which results in increased expression of CYP1A1 protein; Dactinomycin inhibits the reaction [Ketoconazole results in increased expression of CYP1A1 mRNA]; Ketoconazole binds to and results in decreased activity of and results in increased expression of CYP1A1 protein; Ketoconazole inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; Ketoconazole results in increased expression of and results in increased activity of CYP1A1 protein Ketoconazole results in increased expression of CYP1A1 mRNA; Ketoconazole results in increased expression of CYP1A1 protein Ketoconazole binds to and results in decreased activity of and results in increased expression of CYP1A1 protein; Ketoconazole results in increased expression of and results in increased activity of CYP1A1 protein |
CTD |
PMID:14709627 PMID:17283379 PMID:18420780 PMID:18493746 PMID:19070657 PMID:21753779 PMID:25000292 PMID:26886340 PMID:31168027 PMID:34181028 More...
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
multiple interactions decreases activity increases expression |
ISO EXP |
Ketoconazole affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]; Ketoconazole inhibits the reaction [CYP1A2 protein results in increased metabolism of Triazines] Ketoconazole inhibits the reaction [CYP1A2 protein results in increased oxidation of Uroporphyrinogens] Ketoconazole inhibits the reaction [CYP1A2 protein results in increased metabolism of 3-cyano-7-ethoxycoumarin] Ketoconazole results in decreased activity of CYP1A2 protein Ketoconazole results in increased expression of CYP1A2 mRNA; Ketoconazole results in increased expression of CYP1A2 protein |
CTD |
PMID:1567206 PMID:9305587 PMID:12814958 PMID:15618748 PMID:15879494 PMID:15916432 PMID:18420780 PMID:19858067 PMID:24120545 PMID:25000292 More...
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NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
decreases activity |
ISO |
Ketoconazole results in decreased activity of CYP1B1 protein |
CTD |
PMID:14709627 PMID:18420780 |
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NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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G |
Cyp24a1 |
cytochrome P450, family 24, subfamily a, polypeptide 1 |
multiple interactions decreases activity |
EXP ISO |
[Ketoconazole co-treated with Calcitriol] results in increased expression of CYP24A1 mRNA; Ketoconazole inhibits the reaction [Calcitriol results in increased activity of CYP24A1 protein] Ketoconazole results in decreased activity of CYP24A1 protein [Ketoconazole results in decreased metabolism of alfacalcidol] which results in decreased expression of CYP24A1 mRNA; [Ketoconazole results in decreased metabolism of Calcitriol] which results in increased expression of CYP24A1 mRNA; Ketoconazole promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA] Ketoconazole inhibits the reaction [Calcifediol results in increased expression of CYP24A1 mRNA]; Ketoconazole promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA] |
CTD |
PMID:16483768 PMID:16824767 PMID:18840526 PMID:20206692 PMID:26485663 |
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NCBI chr 3:159,275,947...159,290,383
Ensembl chr 3:159,275,947...159,290,383
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G |
Cyp26a1 |
cytochrome P450, family 26, subfamily a, polypeptide 1 |
decreases response to substance multiple interactions decreases activity increases expression |
ISO EXP |
Ketoconazole results in decreased susceptibility to CYP26A1 protein [[Ketoconazole results in decreased activity of CYP26A1 protein] which results in decreased metabolism of Tretinoin] which results in decreased chemical synthesis of 4-hydroxyretinoic acid; [[Ketoconazole results in decreased activity of CYP26A1 protein] which results in decreased metabolism of Tretinoin] which results in decreased chemical synthesis of 4-oxoretinoic acid; [Ketoconazole results in decreased activity of CYP26A1 protein] which results in decreased chemical synthesis of 4-hydroxyretinoic acid; [Ketoconazole results in decreased activity of CYP26A1 protein] which results in decreased chemical synthesis of 4-oxoretinoic acid; [Ketoconazole results in decreased activity of CYP26A1 protein] which results in decreased metabolism of Tretinoin; Ketoconazole inhibits the reaction [CYP26A1 mRNA results in increased chemical synthesis of 4-hydroxyretinoic acid]; Ketoconazole inhibits the reaction [CYP26A1 mRNA results in increased chemical synthesis of 4-oxoretinoic acid]; Ketoconazole inhibits the reaction [CYP26A1 mRNA results in increased metabolism of 4-oxoretinoic acid]; Ketoconazole inhibits the reaction [CYP26A1 mRNA results in increased metabolism of Tretinoin]; Ketoconazole inhibits the reaction [CYP26A1 protein inhibits the reaction [Tretinoin results in increased activity of FAS protein]]; Ketoconazole inhibits the reaction [CYP26A1 protein inhibits the reaction [Tretinoin results in increased activity of TNF protein]]; Ketoconazole inhibits the reaction [CYP26A1 protein inhibits the reaction [Tretinoin results in increased activity of TNFSF10 protein]]; Ketoconazole inhibits the reaction [CYP26A1 protein results in increased metabolism of and results in decreased susceptibility to Tretinoin]; Ketoconazole inhibits the reaction [CYP26A1 protein results in increased metabolism of Tretinoin]; Ketoconazole inhibits the reaction [CYP26A1 results in increased metabolism of Tretinoin] Ketoconazole results in decreased activity of CYP26A1; Ketoconazole results in decreased activity of CYP26A1 protein Ketoconazole results in increased expression of CYP26A1 mRNA |
CTD |
PMID:12091498 PMID:14532297 PMID:15703382 PMID:18059332 PMID:21906690 PMID:25492813 PMID:28263823 PMID:37077353 More...
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NCBI chr 1:235,471,368...235,475,204
Ensembl chr 1:235,471,298...235,475,204
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G |
Cyp26b1 |
cytochrome P450, family 26, subfamily b, polypeptide 1 |
multiple interactions decreases activity |
ISO |
Ketoconazole inhibits the reaction [CYP26B1 protein results in increased metabolism of Tretinoin]; Ketoconazole inhibits the reaction [CYP26B1 results in increased metabolism of Tretinoin] Ketoconazole results in decreased activity of CYP26B1 |
CTD |
PMID:14532297 PMID:21906690 |
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NCBI chr 4:117,041,808...117,058,628
Ensembl chr 4:117,041,808...117,058,628
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G |
Cyp26c1 |
cytochrome P450, family 26, subfamily C, polypeptide 1 |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [CYP26C1 protein results in increased metabolism of alitretinoin]; Ketoconazole inhibits the reaction [CYP26C1 protein results in increased metabolism of Tretinoin] |
CTD |
PMID:21906690 |
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NCBI chr 1:235,458,961...235,468,433
Ensembl chr 1:235,459,356...235,466,842
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G |
Cyp27b1 |
cytochrome P450, family 27, subfamily b, polypeptide 1 |
decreases activity |
EXP |
Ketoconazole results in decreased activity of CYP27B1 protein |
CTD |
PMID:16483768 |
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NCBI chr 7:62,869,340...62,876,242
Ensembl chr 7:62,871,297...62,876,241
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G |
Cyp2a1 |
cytochrome P450, family 2, subfamily a, polypeptide 1 |
affects expression increases expression decreases activity |
EXP |
Ketoconazole affects the expression of CYP2A1 mRNA Ketoconazole results in increased expression of CYP2A1 protein Ketoconazole results in decreased activity of CYP2A1 protein |
CTD |
PMID:7986207 PMID:15879494 PMID:18355885 |
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NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887
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G |
Cyp2a2 |
cytochrome P450, family 2, subfamily a, polypeptide 2 |
multiple interactions |
EXP |
Ketoconazole inhibits the reaction [CYP2A2 protein results in increased metabolism of 7-benzyloxyquinoline] |
CTD |
PMID:19858067 |
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NCBI chr 1:82,263,833...82,289,487
Ensembl chr 1:82,263,833...82,289,487
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G |
Cyp2a3 |
cytochrome P450, family 2, subfamily a, polypeptide 3 |
decreases activity |
ISO |
Ketoconazole results in decreased activity of CYP2A4 protein |
CTD |
PMID:18420780 |
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NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979
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G |
Cyp2b1 |
cytochrome P450, family 2, subfamily b, polypeptide 1 |
multiple interactions |
EXP |
Ketoconazole inhibits the reaction [CYP2B1 protein results in increased metabolism of 7-benzyloxy-4-trifluoromethylcoumarin] |
CTD |
PMID:19858067 |
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NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
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G |
Cyp2b15 |
cytochrome P450, family 2, subfamily b, polypeptide 15 |
affects expression |
EXP |
Ketoconazole affects the expression of CYP2B15 mRNA |
CTD |
PMID:18355885 |
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NCBI chr 1:82,094,188...82,106,492
Ensembl chr 1:82,094,180...82,106,492
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G |
Cyp2b3 |
cytochrome P450, family 2, subfamily b, polypeptide 3 |
decreases activity multiple interactions increases expression |
ISO |
Ketoconazole results in decreased activity of CYP2B6 protein Ketoconazole inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]; Ketoconazole inhibits the reaction [Phenobarbital results in increased expression of CYP2B6 mRNA]; Ketoconazole inhibits the reaction [Rifampin results in increased expression of CYP2B6 mRNA] Ketoconazole results in increased expression of CYP2B10 mRNA Ketoconazole results in decreased activity of CYP2B10 protein |
CTD |
PMID:14709627 PMID:16608920 PMID:17438109 PMID:17966066 PMID:18420780 |
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NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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G |
Cyp2c11 |
cytochrome P450, subfamily 2, polypeptide 11 |
multiple interactions decreases activity |
EXP |
Ketoconazole inhibits the reaction [CYP2C11 protein results in increased metabolism of 7-methoxy-4-trifluoromethylcoumarin] Ketoconazole results in decreased activity of CYP2C11 protein |
CTD |
PMID:15879494 PMID:19858067 |
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NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
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G |
Cyp2c6 |
cytochrome P450, family 2, subfamily C, polypeptide 6 |
multiple interactions decreases activity |
EXP ISO |
Ketoconazole inhibits the reaction [CYP2C6 protein results in increased metabolism of 7-methoxy-4-trifluoromethylcoumarin] Ketoconazole results in decreased activity of CYP2C6 protein Ketoconazole results in decreased activity of CYP2C19 protein Ketoconazole affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] Ketoconazole results in decreased activity of CYP2C29 protein |
CTD |
PMID:12814958 PMID:14709627 PMID:15618748 PMID:15879494 PMID:18420780 PMID:19858067 PMID:24120545 More...
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NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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G |
Cyp2c79 |
cytochrome P450, family 2, subfamily c, polypeptide 79 |
decreases activity multiple interactions |
ISO |
Ketoconazole results in decreased activity of CYP2C8 protein Ketoconazole affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] |
CTD |
PMID:14709627 PMID:15601807 PMID:24120545 |
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G |
Cyp2d2 |
cytochrome P450, family 2, subfamily d, polypeptide 2 |
multiple interactions |
EXP |
Ketoconazole inhibits the reaction [CYP2D2 protein results in increased metabolism of 3-(2-(N,N-diethyl-N-methylammonium)ethyl)-7-methoxy-4-methylcoumarin] |
CTD |
PMID:19858067 |
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NCBI chr 7:113,935,138...113,939,209
Ensembl chr 7:113,935,138...113,939,209
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G |
Cyp2d4 |
cytochrome P450, family 2, subfamily d, polypeptide 4 |
multiple interactions decreases activity decreases expression |
ISO |
Ketoconazole affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]; Ketoconazole inhibits the reaction [CYP2D6 protein results in increased metabolism of YM 758] Ketoconazole results in decreased activity of CYP2D6 protein Ketoconazole inhibits the reaction [CYP2D22 protein results in increased metabolism of Dextromethorphan]; Ketoconazole inhibits the reaction [Maneb results in decreased expression of CYP2D22 protein]; Ketoconazole inhibits the reaction [Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP2D22 mRNA]]; Ketoconazole inhibits the reaction [Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP2D22 protein]]; Ketoconazole inhibits the reaction [Nicotine results in increased expression of CYP2D22 mRNA]; Ketoconazole inhibits the reaction [Nicotine results in increased expression of CYP2D22 protein]; Ketoconazole inhibits the reaction [Paraquat results in decreased expression of CYP2D22 protein]; Ketoconazole promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP2D22 mRNA]; Ketoconazole promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP2D22 protein]; Nicotine inhibits the reaction [Ketoconazole results in decreased expression of CYP2D22 mRNA]; Nicotine inhibits the reaction [Ketoconazole results in decreased expression of CYP2D22 protein] Ketoconazole results in decreased activity of CYP2D22 protein; Ketoconazole results in decreased activity of CYP2D6 protein Ketoconazole results in decreased expression of CYP2D22 mRNA; Ketoconazole results in decreased expression of CYP2D22 protein |
CTD |
PMID:15618748 PMID:16595712 PMID:18420780 PMID:19230594 PMID:19594327 PMID:22334051 PMID:24120545 More...
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NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
decreases activity |
ISO |
Ketoconazole results in decreased activity of CYP2E1 protein |
CTD |
PMID:15618748 |
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NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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G |
Cyp2j4 |
cytochrome P450, family 2, subfamily j, polypeptide 4 |
decreases activity |
ISO |
Ketoconazole results in decreased activity of CYP2J2 protein |
CTD |
PMID:12851038 |
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NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
multiple interactions decreases activity increases metabolic processing increases expression increases response to substance decreases expression |
EXP ISO |
Ketoconazole inhibits the reaction [CYP3A2 protein results in increased metabolism of 7-benzyloxyquinoline]; Ketoconazole inhibits the reaction [Phenytoin results in increased expression of CYP3A2 protein] Ketoconazole results in decreased activity of CYP3A2 protein; Ketoconazole results in decreased activity of CYP3A4 protein [Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of BCL2 protein; [Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of MCL1 protein; [Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in increased expression of BAX protein; [Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased chemical synthesis of 1-hydroxymethylmidazolam; [Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased degradation of vanoxerine; [Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased hydroxylation of Midazolam; [Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased metabolism of Midazolam; [Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased metabolism of Testosterone; [Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased metabolism of Triazolam; Ketoconazole affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]; Ketoconazole affects the reaction [CYP3A4 polymorphism affects the metabolism of cabozantinib]; Ketoconazole affects the reaction [CYP3A4 protein alternative form affects the metabolism of acalabrutinib]; Ketoconazole affects the reaction [CYP3A4 protein alternative form affects the metabolism of vandetanib]; Ketoconazole binds to and results in decreased activity of CYP3A4 protein; Ketoconazole inhibits the reaction [3,3'-diindolylmethane results in increased expression of CYP3A4 mRNA]; Ketoconazole inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP3A4 mRNA]; Ketoconazole inhibits the reaction [[2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with NADP] results in decreased activity of CYP3A4 protein]; Ketoconazole inhibits the reaction [[Amiodarone co-treated with CYP3A4 protein] results in increased expression of CXCL8 mRNA]; Ketoconazole inhibits the reaction [[Amiodarone co-treated with CYP3A4 protein] results in increased expression of TNF mRNA]; Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac]; Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac]; Ketoconazole inhibits the reaction [[CYP3A4 protein results in increased hydroxylation of Testosterone] which results in increased chemical synthesis of 6 beta-hydroxytestosterone]; Ketoconazole inhibits the reaction [[CYP3A4 protein results in increased hydroxylation of Testosterone] which results in increased chemical synthesis of Hydroxytestosterones]; Ketoconazole inhibits the reaction [[desethylamiodarone co-treated with CYP3A4 protein] results in increased expression of CXCL8 mRNA]; Ketoconazole inhibits the reaction [[desethylamiodarone co-treated with CYP3A4 protein] results in increased expression of TNF mRNA]; Ketoconazole inhibits the reaction [Calcitriol results in increased expression of CYP3A4 protein]; Ketoconazole inhibits the reaction [Corticosterone promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]; Ketoconazole inhibits the reaction [Corticosterone results in increased expression of CYP3A4 mRNA]; Ketoconazole inhibits the reaction [CYP3A4 protein affects the metabolism of Endosulfan]; Ketoconazole inhibits the reaction [CYP3A4 protein affects the metabolism of Mefloquine]; Ketoconazole inhibits the reaction [CYP3A4 protein promotes the reaction [Oxygen deficiency results in increased expression of EPO mRNA]]; Ketoconazole inhibits the reaction [CYP3A4 protein promotes the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]]; Ketoconazole inhibits the reaction [CYP3A4 protein results in decreased abundance of Midazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in decreased methylation of adinazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in decreased methylation of mono-N-demethyladinazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in decreased susceptibility to Docetaxel]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased abundance of 1-hydroxymethylmidazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 11,12-epoxy-5,8,14-eicosatrienoic acid]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 14,15-epoxy-5,8,11-eicosatrienoic acid]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 3'-p-hydroxypaclitaxel]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 4-hydroxymidazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 5,6-epoxy-8,11,14-eicosatrienoic acid]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 6 beta-hydroxytestosterone]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 8,9-epoxyeicosatrienoic acid]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of clozapine N-oxide]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of norclozapine]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased degradation of Clopidogrel]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased degradation of Ticlopidine]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased glutathionylation of dauricine]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydrolysis of Testosterone]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Carbofuran]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Cholecalciferol]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Metoprolol]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of mono-N-desethylamiodarone]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of nefazodone]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Nifedipine]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of 8-epidiosbulbin E acetate]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of and results in decreased abundance of Quetiapine Fumarate]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Arachidonic Acid]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of bufalin]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of bufogenin]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of cabozantinib]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of carbosulfan]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of cinobufagin]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of eldecalcitol]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Felodipine]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of laquinimod]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Midazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Terfenadine]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Testosterone]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Triazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of YM 758]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of 2-oxo-clopidogrel]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of dimemorfan]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of Lithocholic Acid]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of Nifedipine]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of Paclitaxel]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Clopidogrel]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Endosulfan]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Ticlopidine]; Ketoconazole inhibits the reaction [erdafitinib results in decreased activity of CYP3A4 protein]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [piperine results in increased expression of CYP3A4 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [piperine results in increased expression of CYP3A4 protein]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 protein]]; Ketoconazole inhibits the reaction [Paclitaxel results in increased expression of CYP3A4 mRNA]; Ketoconazole inhibits the reaction [Paclitaxel results in increased expression of CYP3A4 protein]; Ketoconazole inhibits the reaction [Phenobarbital results in increased expression of CYP3A4 mRNA]; Ketoconazole inhibits the reaction [Rifampin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]; Ketoconazole inhibits the reaction [Rifampin results in increased activity of CYP3A4 protein]; Ketoconazole inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; Ketoconazole inhibits the reaction [Rifampin results in increased expression of CYP3A4 protein]; Ketoconazole inhibits the reaction [U 0126 affects the activity of CYP3A4 protein]; Ketoconazole results in increased expression of and results in decreased activity of CYP3A4 protein CYP3A4 protein results in increased metabolism of Ketoconazole Ketoconazole results in increased expression of CYP3A4 mRNA CYP3A4 protein results in increased susceptibility to Ketoconazole Ketoconazole results in decreased expression of CYP3A4 mRNA; Ketoconazole results in decreased expression of CYP3A4 protein |
CTD |
PMID:9600717 PMID:10952769 PMID:10997946 PMID:11377097 PMID:11502731 PMID:12072427 PMID:12237780 PMID:12569440 PMID:12675279 PMID:12695342 PMID:12814958 PMID:15005856 PMID:15135088 PMID:15279827 PMID:15306208 PMID:15328084 PMID:15466163 PMID:15557344 PMID:15560889 PMID:15618748 PMID:15731592 PMID:15764719 PMID:15784650 PMID:15860655 PMID:15869686 PMID:15879494 PMID:15896247 PMID:15969931 PMID:16012074 PMID:16146350 PMID:16204965 PMID:16207822 PMID:16390352 PMID:16608920 PMID:16819505 PMID:16855053 PMID:17438109 PMID:17702393 PMID:17998298 PMID:18799805 PMID:18809730 PMID:18846481 PMID:19226368 PMID:19230594 PMID:19299527 PMID:19328226 PMID:19358519 PMID:19593786 PMID:19812348 PMID:19858067 PMID:20233841 PMID:20307514 PMID:20507880 PMID:20863320 PMID:21336516 PMID:21349323 PMID:21402137 PMID:21566342 PMID:21915887 PMID:22178124 PMID:22447115 PMID:22651985 PMID:22785256 PMID:23146034 PMID:23274770 PMID:23707768 PMID:23850985 PMID:23876819 PMID:24120545 PMID:24246759 PMID:24799337 PMID:24819614 PMID:25343516 PMID:25542144 PMID:26038696 PMID:26286065 PMID:26718876 PMID:27485346 PMID:27871908 PMID:28119166 PMID:28238727 PMID:28887089 PMID:29782822 PMID:30087611 PMID:31102695 PMID:31293154 PMID:31629065 PMID:31870919 PMID:33253783 PMID:33438235 PMID:33775687 PMID:34153224 PMID:34189909 PMID:34648813 PMID:34780725 PMID:36332690 PMID:36893891 More...
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NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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G |
Cyp3a23-3a1 |
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 |
multiple interactions affects expression decreases activity |
EXP |
[Strychnine co-treated with Ketoconazole] results in decreased expression of CYP3A23-3A1 protein; Ketoconazole inhibits the reaction [CYP3A23-3A1 protein results in increased metabolism of 7-benzyloxyquinoline]; Ketoconazole inhibits the reaction [Genistein results in increased expression of CYP3A23-3A1 mRNA] Ketoconazole affects the expression of CYP3A23-3A1 mRNA Ketoconazole results in decreased activity of CYP3A23-3A1 protein |
CTD |
PMID:12814958 PMID:15879494 PMID:18355885 PMID:19858067 PMID:32185415 PMID:35358606 More...
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NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030 Ensembl chr12:9,254,475...9,285,030
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G |
Cyp3a9 |
cytochrome P450, family 3, subfamily a, polypeptide 9 |
multiple interactions decreases activity affects response to substance |
ISO |
CYP3A5 gene polymorphism affects the reaction [Ketoconazole results in decreased metabolism of Tacrolimus]; Ketoconazole inhibits the reaction [Beclomethasone results in increased expression of CYP3A5 mRNA]; Ketoconazole inhibits the reaction [Budesonide results in increased expression of CYP3A5 mRNA]; Ketoconazole inhibits the reaction [CYP3A5 protein affects the metabolism of Alfentanil]; Ketoconazole inhibits the reaction [CYP3A5 protein results in increased hydroxylation of Testosterone]; Ketoconazole inhibits the reaction [CYP3A5 protein results in increased oxidation of Lithocholic Acid]; Ketoconazole inhibits the reaction [erdafitinib results in decreased activity of CYP3A5 protein]; Ketoconazole inhibits the reaction [flunisolide results in increased expression of CYP3A5 mRNA]; Ketoconazole inhibits the reaction [Fluticasone results in increased expression of CYP3A5 mRNA]; Ketoconazole inhibits the reaction [Triamcinolone Acetonide results in increased expression of CYP3A5 mRNA] Ketoconazole results in decreased activity of CYP3A5 protein CYP3A5 gene polymorphism affects the susceptibility to Ketoconazole |
CTD |
PMID:15557344 PMID:15731592 PMID:19384264 PMID:24555085 PMID:26302866 PMID:31102695 PMID:34189909 PMID:37788138 More...
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NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
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Cyp4b1 |
cytochrome P450, family 4, subfamily b, polypeptide 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of CYP4B1 mRNA |
CTD |
PMID:37077353 |
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NCBI chr 5:129,139,019...129,176,860
Ensembl chr 5:129,139,038...129,156,348
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G |
Cyp4f1 |
cytochrome P450, family 4, subfamily f, polypeptide 1 |
decreases activity |
ISO |
Ketoconazole results in decreased activity of CYP4F12 protein |
CTD |
PMID:14709627 |
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NCBI chr 7:12,010,850...12,022,497
Ensembl chr 7:12,010,852...12,022,046
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Cyp4f4 |
cytochrome P450, family 4, subfamily f, polypeptide 4 |
affects expression |
EXP |
Ketoconazole affects the expression of CYP4F2 mRNA |
CTD |
PMID:18355885 |
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NCBI chr 7:11,717,208...11,733,507
Ensembl chr 7:11,717,208...11,733,506
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G |
Cyp51 |
cytochrome P450, family 51 |
decreases activity increases expression increases activity multiple interactions decreases response to substance |
ISO EXP |
Ketoconazole results in decreased activity of CYP51A1 protein Ketoconazole results in increased expression of CYP51 mRNA; Ketoconazole results in increased expression of CYP51 protein Ketoconazole results in increased activity of CYP51 protein CYP51A1 gene inhibits the reaction [Ketoconazole results in decreased chemical synthesis of Ergosterol]; CYP51A1 gene inhibits the reaction [Ketoconazole results in decreased metabolism of and results in increased abundance of 14-methylergosta-8,24(28)-dien-3,6-diol]; CYP51A1 gene inhibits the reaction [Ketoconazole results in decreased metabolism of and results in increased abundance of Lanosterol] [Ketoconazole results in increased activity of CYP51 protein] which results in increased abundance of Lanosterol CYP51A1 gene results in decreased susceptibility to Ketoconazole |
CTD |
PMID:12617470 PMID:16989930 PMID:17966066 PMID:18694951 PMID:28263823 PMID:29337257 More...
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NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410
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G |
Cyp7a1 |
cytochrome P450 family 7 subfamily A member 1 |
multiple interactions increases expression |
EXP ISO |
[Chenodeoxycholic Acid co-treated with Ketoconazole] results in decreased expression of CYP7A1 mRNA Ketoconazole results in increased expression of CYP7A1 mRNA |
CTD |
PMID:30985903 PMID:31099283 |
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NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
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G |
Dcaf8 |
DDB1 and CUL4 associated factor 8 |
affects expression |
EXP |
Ketoconazole affects the expression of DCAF8 mRNA |
CTD |
PMID:18355885 |
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NCBI chr13:84,609,838...84,667,025
Ensembl chr13:84,610,248...84,669,726
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G |
Dcakd |
dephospho-CoA kinase domain containing |
increases expression |
EXP |
Ketoconazole results in increased expression of DCAKD mRNA |
CTD |
PMID:36653537 |
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NCBI chr10:87,957,738...87,989,002
Ensembl chr10:87,957,740...87,980,054
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G |
Ddb1 |
damage-specific DNA binding protein 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of DDB1 mRNA |
CTD |
PMID:36621641 |
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NCBI chr 1:207,252,890...207,278,685
Ensembl chr 1:207,252,890...207,278,676
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
increases expression multiple interactions affects expression |
ISO |
Ketoconazole results in increased expression of DDIT3 mRNA EIF2S1 protein mutant form inhibits the reaction [Ketoconazole results in increased expression of DDIT3 mRNA] Ketoconazole affects the expression of DDIT3 mRNA |
CTD |
PMID:16330322 PMID:31099283 PMID:36621641 |
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NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Depp1 |
DEPP autophagy regulator 1 |
decreases expression increases expression |
ISO |
Ketoconazole results in decreased expression of DEPP1 mRNA Ketoconazole results in increased expression of DEPP1 mRNA |
CTD |
PMID:15342952 PMID:17175557 |
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NCBI chr 4:149,910,794...149,913,013
Ensembl chr 4:149,910,779...149,914,542
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G |
Desi2 |
desumoylating isopeptidase 2 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of DESI2 mRNA |
CTD |
PMID:36621641 |
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NCBI chr13:89,961,767...90,011,255
Ensembl chr13:89,961,934...90,016,416
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G |
Dgka |
diacylglycerol kinase, alpha |
decreases expression |
EXP |
Ketoconazole results in decreased expression of DGKA mRNA |
CTD |
PMID:37077353 |
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NCBI chr 7:1,148,734...1,175,324
Ensembl chr 7:1,148,735...1,175,110
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G |
Dhcr7 |
7-dehydrocholesterol reductase |
increases expression |
EXP ISO |
Ketoconazole results in increased expression of DHCR7 mRNA |
CTD |
PMID:28263823 PMID:36621641 PMID:36653537 |
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NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055
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Dhrs3 |
dehydrogenase/reductase 3 |
increases expression |
EXP |
Ketoconazole results in increased expression of DHRS3 mRNA |
CTD |
PMID:37077353 |
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NCBI chr 5:156,747,939...156,782,420
Ensembl chr 5:156,747,962...156,782,417
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G |
Dhx9 |
DExH-box helicase 9 |
increases expression |
ISO |
Ketoconazole results in increased expression of DHX9 mRNA |
CTD |
PMID:36621641 |
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NCBI chr13:65,602,322...65,639,098
Ensembl chr13:65,602,323...65,639,069
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G |
Dlat |
dihydrolipoamide S-acetyltransferase |
decreases expression |
EXP |
Ketoconazole results in decreased expression of DLAT mRNA |
CTD |
PMID:37077353 |
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NCBI chr 8:50,979,151...51,004,435
Ensembl chr 8:50,978,051...51,004,479
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G |
Dlc1 |
DLC1 Rho GTPase activating protein |
decreases expression |
EXP |
Ketoconazole results in decreased expression of DLC1 mRNA |
CTD |
PMID:36653537 |
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NCBI chr16:55,246,716...55,671,441
Ensembl chr16:55,291,584...55,671,439
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G |
Dlk1 |
delta like non-canonical Notch ligand 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of DLK1 mRNA |
CTD |
PMID:37077353 |
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NCBI chr 6:128,410,216...128,417,518
Ensembl chr 6:128,410,316...128,417,522
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G |
Dmc1 |
DNA meiotic recombinase 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of DMC1 mRNA |
CTD |
PMID:16574651 |
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NCBI chr 7:111,124,888...111,167,465
Ensembl chr 7:111,124,888...111,167,952
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G |
Dmxl1 |
Dmx-like 1 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of DMXL1 mRNA |
CTD |
PMID:36621641 |
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NCBI chr18:42,993,292...43,163,457
Ensembl chr18:42,993,340...43,163,456
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G |
Dnase1l1 |
deoxyribonuclease 1-like 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of DNASE1L1 mRNA |
CTD |
PMID:36653537 |
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NCBI chr X:152,056,942...152,065,518
Ensembl chr X:152,056,942...152,065,518
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G |
Dnmt3a |
DNA methyltransferase 3 alpha |
increases expression decreases expression |
EXP |
Ketoconazole results in increased expression of DNMT3A mRNA Ketoconazole results in decreased expression of DNMT3A mRNA |
CTD |
PMID:37077353 |
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NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687
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G |
Dnmt3b |
DNA methyltransferase 3 beta |
decreases expression |
EXP |
Ketoconazole results in decreased expression of DNMT3B mRNA |
CTD |
PMID:37077353 |
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NCBI chr 3:142,130,588...142,169,128
Ensembl chr 3:142,130,592...142,169,124
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G |
Dock1 |
dedicator of cyto-kinesis 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of DOCK1 mRNA |
CTD |
PMID:36653537 |
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NCBI chr 1:189,467,143...189,983,777
Ensembl chr 1:189,467,143...189,983,768
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G |
Dock6 |
dedicator of cytokinesis 6 |
increases expression |
EXP |
Ketoconazole results in increased expression of DOCK6 mRNA |
CTD |
PMID:36653537 |
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NCBI chr 8:20,342,430...20,394,660
Ensembl chr 8:20,342,089...20,394,552
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G |
Dok7 |
docking protein 7 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of DOK7 mRNA |
CTD |
PMID:36621641 |
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NCBI chr14:75,665,444...75,699,413
Ensembl chr14:75,666,744...75,699,386
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G |
Dpcd |
deleted in primary ciliary dyskinesia |
increases expression |
ISO |
Ketoconazole results in increased expression of DPCD mRNA |
CTD |
PMID:36621641 |
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NCBI chr 1:244,408,766...244,426,891
Ensembl chr 1:244,408,785...244,426,888
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G |
Drd4 |
dopamine receptor D4 |
decreases expression multiple interactions |
ISO |
Ketoconazole results in decreased expression of DRD4 mRNA Ketoconazole inhibits the reaction [FSHB protein results in increased expression of DRD4 mRNA]; Metribolone inhibits the reaction [Ketoconazole results in decreased expression of DRD4 mRNA] |
CTD |
PMID:19587329 |
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NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553
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G |
Drosha |
drosha ribonuclease III |
decreases expression |
EXP |
Ketoconazole results in decreased expression of DROSHA mRNA |
CTD |
PMID:36653537 |
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NCBI chr 2:61,864,886...61,976,688
Ensembl chr 2:61,864,970...61,976,688
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G |
Dusp1 |
dual specificity phosphatase 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of DUSP1 mRNA |
CTD |
PMID:25787151 |
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NCBI chr10:16,680,478...16,683,275
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G |
Ednrb |
endothelin receptor type B |
increases expression |
EXP |
Ketoconazole results in increased expression of EDNRB mRNA |
CTD |
PMID:36653537 |
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NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115
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G |
Egf |
epidermal growth factor |
increases uptake multiple interactions |
ISO |
Ketoconazole results in increased uptake of EGF protein Ketoconazole inhibits the reaction [EGF protein results in increased uptake of and results in increased degradation of EGFR protein] |
CTD |
PMID:23125191 |
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NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064
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G |
Egfr |
epidermal growth factor receptor |
multiple interactions decreases expression |
ISO EXP |
Ketoconazole inhibits the reaction [EGF protein results in increased uptake of and results in increased degradation of EGFR protein] Ketoconazole results in decreased expression of EGFR mRNA |
CTD |
PMID:23125191 PMID:37077353 |
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NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
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G |
Egln1 |
egl-9 family hypoxia-inducible factor 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of EGLN1 mRNA |
CTD |
PMID:37077353 |
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NCBI chr19:52,867,900...52,907,308
Ensembl chr19:52,869,486...52,907,777
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G |
Egln3 |
egl-9 family hypoxia-inducible factor 3 |
increases expression |
EXP |
Ketoconazole results in increased expression of EGLN3 mRNA |
CTD |
PMID:37077353 |
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NCBI chr 6:71,650,297...71,675,766
Ensembl chr 6:71,650,297...71,675,766
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G |
Eif1ad |
eukaryotic translation initiation factor 1A domain containing |
increases expression |
ISO |
Ketoconazole results in increased expression of EIF1AD mRNA |
CTD |
PMID:36621641 |
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NCBI chr 1:202,674,362...202,679,662
Ensembl chr 1:202,674,185...202,679,658
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G |
Eif2ak3 |
eukaryotic translation initiation factor 2 alpha kinase 3 |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [Tunicamycin results in increased phosphorylation of EIF2AK3 protein] |
CTD |
PMID:16330322 |
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NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
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G |
Eif2s1 |
eukaryotic translation initiation factor 2 subunit alpha |
multiple interactions |
ISO |
EIF2S1 protein mutant form inhibits the reaction [Ketoconazole results in increased expression of DDIT3 mRNA]; EIF2S1 protein mutant form promotes the reaction [Ketoconazole results in increased expression of IDI1 mRNA]; EIF2S1 protein mutant form promotes the reaction [Ketoconazole results in increased expression of MSMO1 mRNA] |
CTD |
PMID:16330322 |
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NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
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Eif3e |
eukaryotic translation initiation factor 3 subunit E |
decreases expression |
ISO |
Ketoconazole results in decreased expression of EIF3E mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 7:74,339,848...74,372,483
Ensembl chr 7:74,339,828...74,373,096
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G |
Eif3m |
eukaryotic translation initiation factor 3, subunit M |
increases expression |
ISO |
Ketoconazole results in increased expression of EIF3M mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 3:91,424,754...91,442,358
Ensembl chr 3:91,416,325...91,442,392
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G |
Eif4b |
eukaryotic translation initiation factor 4B |
affects expression |
EXP |
Ketoconazole affects the expression of EIF4B mRNA |
CTD |
PMID:18355885 |
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NCBI chr 7:133,206,637...133,228,436
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G |
Eif4ebp1 |
eukaryotic translation initiation factor 4E binding protein 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of EIF4EBP1 mRNA |
CTD |
PMID:37077353 |
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NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
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G |
Elac1 |
elaC ribonuclease Z 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of ELAC1 mRNA |
CTD |
PMID:36653537 |
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NCBI chr18:67,321,231...67,341,358
Ensembl chr18:67,323,583...67,340,936
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G |
Elovl5 |
ELOVL fatty acid elongase 5 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of ELOVL5 mRNA |
CTD |
PMID:36621641 |
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NCBI chr 8:78,790,846...78,857,307
Ensembl chr 8:78,790,846...78,857,284
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G |
Elovl6 |
ELOVL fatty acid elongase 6 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of ELOVL6 mRNA |
CTD |
PMID:37077353 |
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NCBI chr 2:218,063,682...218,174,767
Ensembl chr 2:218,063,804...218,171,186
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G |
Enpp3 |
ectonucleotide pyrophosphatase/phosphodiesterase 3 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of ENPP3 mRNA |
CTD |
PMID:31099283 |
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NCBI chr 1:20,563,700...20,635,044
Ensembl chr 1:20,563,697...20,635,041
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G |
Epas1 |
endothelial PAS domain protein 1 |
increases expression |
EXP ISO |
Ketoconazole results in increased expression of EPAS1 mRNA |
CTD |
PMID:36621641 PMID:37077353 |
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NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228
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G |
Epb41l3 |
erythrocyte membrane protein band 4.1-like 3 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of EPB41L3 mRNA |
CTD |
PMID:36653537 |
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NCBI chr 9:109,056,178...109,260,607
Ensembl chr 9:109,016,113...109,260,607
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G |
Ephx1 |
epoxide hydrolase 1 |
affects expression increases expression |
EXP |
Ketoconazole affects the expression of EPHX1 mRNA Ketoconazole results in increased expression of EPHX1 mRNA |
CTD |
PMID:18355885 PMID:37077353 |
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NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235
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G |
Epo |
erythropoietin |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [CYP3A4 protein promotes the reaction [Oxygen deficiency results in increased expression of EPO mRNA]]; Ketoconazole inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA] |
CTD |
PMID:21566342 |
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NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
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G |
Eppin |
epididymal peptidase inhibitor |
multiple interactions decreases expression |
ISO |
Ketoconazole inhibits the reaction [FSHB protein results in increased expression of EPPIN mRNA]; Metribolone inhibits the reaction [Ketoconazole results in decreased expression of EPPIN mRNA] |
CTD |
PMID:19587329 |
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NCBI chr 3:153,312,396...153,319,310
Ensembl chr 3:153,312,396...153,319,310
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G |
Eral1 |
Era-like 12S mitochondrial rRNA chaperone 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of ERAL1 mRNA |
CTD |
PMID:36653537 |
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NCBI chr10:62,961,725...62,968,747
Ensembl chr10:62,961,730...62,968,994
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G |
Erc1 |
ELKS/RAB6-interacting/CAST family member 1 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of ERC1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 4:152,763,664...153,055,724
Ensembl chr 4:152,767,419...153,055,639
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Ereg |
epiregulin |
increases expression |
ISO |
Ketoconazole results in increased expression of EREG mRNA |
CTD |
PMID:32816093 |
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NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062
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G |
Ero1a |
endoplasmic reticulum oxidoreductase 1 alpha |
decreases expression |
EXP |
Ketoconazole results in decreased expression of ERO1A mRNA |
CTD |
PMID:37077353 |
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NCBI chr15:18,495,037...18,530,440
Ensembl chr15:18,492,945...18,530,478
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G |
Erp29 |
endoplasmic reticulum protein 29 |
affects expression |
EXP |
Ketoconazole affects the expression of ERP29 mRNA |
CTD |
PMID:18355885 |
|
NCBI chr12:35,089,698...35,095,952
Ensembl chr12:35,089,707...35,096,376
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G |
Esco2 |
establishment of sister chromatid cohesion N-acetyltransferase 2 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of ESCO2 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr15:40,034,566...40,052,295
Ensembl chr15:40,034,568...40,055,306
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G |
Esr1 |
estrogen receptor 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of ESR1 mRNA |
CTD |
PMID:37077353 |
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NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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G |
Esrra |
estrogen related receptor, alpha |
increases expression |
EXP |
Ketoconazole results in increased expression of ESRRA mRNA |
CTD |
PMID:37077353 |
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NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268
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G |
Ets1 |
ETS proto-oncogene 1, transcription factor |
decreases expression |
EXP |
Ketoconazole results in decreased expression of ETS1 mRNA |
CTD |
PMID:37077353 |
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NCBI chr 8:31,045,909...31,168,010
Ensembl chr 8:31,045,945...31,168,010
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G |
Exoc6b |
exocyst complex component 6B |
increases expression |
ISO |
Ketoconazole results in increased expression of EXOC6B mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 4:117,094,741...117,550,221
Ensembl chr 4:117,094,741...117,550,180
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G |
Ezh1 |
enhancer of zeste 1 polycomb repressive complex 2 subunit |
increases expression |
EXP |
Ketoconazole results in increased expression of EZH1 mRNA |
CTD |
PMID:37077353 |
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NCBI chr10:86,126,023...86,162,001
Ensembl chr10:86,126,015...86,161,921
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G |
Ezh2 |
enhancer of zeste 2 polycomb repressive complex 2 subunit |
decreases expression |
EXP |
Ketoconazole results in decreased expression of EZH2 mRNA |
CTD |
PMID:37077353 |
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NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362
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G |
F3 |
coagulation factor III, tissue factor |
increases expression |
ISO |
Ketoconazole results in increased expression of F3 protein |
CTD |
PMID:25569083 |
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NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
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G |
Fabp1 |
fatty acid binding protein 1 |
increases expression |
ISO EXP |
Ketoconazole results in increased expression of FABP1 mRNA |
CTD |
PMID:15342952 PMID:17175557 PMID:17567588 PMID:36653537 |
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NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788
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G |
Fabp3 |
fatty acid binding protein 3 |
increases expression |
EXP |
Ketoconazole results in increased expression of FABP3 mRNA |
CTD |
PMID:37077353 |
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NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718
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G |
Fabp4 |
fatty acid binding protein 4 |
increases expression |
EXP |
Ketoconazole results in increased expression of FABP4 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578
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G |
Fabp5 |
fatty acid binding protein 5 |
increases expression |
EXP ISO |
Ketoconazole results in increased expression of FABP5 mRNA |
CTD |
PMID:31099283 PMID:37077353 |
|
NCBI chr 2:91,765,056...91,768,716
Ensembl chr 2:91,765,056...91,853,773
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G |
Faf1 |
Fas associated factor 1 |
increases expression |
ISO EXP |
Ketoconazole results in increased expression of FAF1 mRNA |
CTD |
PMID:25808816 |
|
NCBI chr 5:124,426,032...124,790,014
Ensembl chr 5:124,426,062...124,789,977
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|
G |
Fam20c |
FAM20C, golgi associated secretory pathway kinase |
increases expression |
EXP |
Ketoconazole results in increased expression of FAM20C mRNA |
CTD |
PMID:37077353 |
|
NCBI chr12:15,826,864...15,885,423
Ensembl chr12:15,826,871...15,884,543
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G |
Fas |
Fas cell surface death receptor |
increases expression multiple interactions |
ISO EXP |
Ketoconazole results in increased expression of FAS mRNA Ketoconazole inhibits the reaction [CYP26A1 protein inhibits the reaction [Tretinoin results in increased activity of FAS protein]] |
CTD |
PMID:15703382 PMID:25808816 |
|
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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|
G |
Fbxl14 |
F-box and leucine-rich repeat protein 14 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of FBXL14 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr 4:152,662,542...152,666,360
Ensembl chr 4:152,662,542...152,666,360
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|
G |
Fbxl15 |
F-box and leucine-rich repeat protein 15 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of FBXL15 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 1:245,189,732...245,191,973
Ensembl chr 1:245,189,736...245,192,007
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G |
Fbxo21 |
F-box protein 21 |
increases expression |
ISO |
Ketoconazole results in increased expression of FBXO21 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr12:38,570,878...38,605,133
Ensembl chr12:38,571,023...38,605,133
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|
G |
Fbxw2 |
F-box and WD repeat domain containing 2 |
increases expression |
ISO |
Ketoconazole results in increased expression of FBXW2 mRNA |
CTD |
PMID:31099283 |
|
NCBI chr 3:18,088,859...18,114,387
Ensembl chr 3:18,088,865...18,114,381
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|
G |
Fdft1 |
farnesyl diphosphate farnesyl transferase 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of FDFT1 mRNA |
CTD |
PMID:28263823 |
|
NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287
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|
G |
Fdps |
farnesyl diphosphate synthase |
increases expression |
EXP |
Ketoconazole results in increased expression of FDPS mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776
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|
G |
Fdx1 |
ferredoxin 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of FDX1 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr 8:52,268,536...52,287,344
Ensembl chr 8:52,268,536...52,287,414
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|
G |
Fezf1 |
Fez family zinc finger 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of FEZF1 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 4:51,762,751...51,766,078
Ensembl chr 4:51,762,751...51,766,078
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|
G |
Fgfbp3 |
fibroblast growth factor binding protein 3 |
increases expression |
EXP |
Ketoconazole results in increased expression of FGFBP3 mRNA |
CTD |
PMID:28263823 |
|
NCBI chr 1:234,644,023...234,646,028
Ensembl chr 1:234,644,019...234,646,547
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|
G |
Flad1 |
flavin adenine dinucleotide synthetase 1 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of FLAD1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 2:174,819,451...174,828,921
Ensembl chr 2:174,819,453...174,828,977
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|
G |
Fn1 |
fibronectin 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of FN1 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
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|
G |
Fndc4 |
fibronectin type III domain containing 4 |
increases expression |
ISO |
Ketoconazole results in increased expression of FNDC4 mRNA |
CTD |
PMID:15342952 PMID:17175557 PMID:17567588 |
|
NCBI chr 6:25,077,155...25,080,812
Ensembl chr 6:25,077,349...25,080,675
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|
G |
Fosl1 |
FOS like 1, AP-1 transcription factor subunit |
decreases expression increases expression |
EXP ISO |
Ketoconazole results in decreased expression of FOSL1 mRNA Ketoconazole results in increased expression of FOSL1 mRNA |
CTD |
PMID:25787151 PMID:31099283 |
|
NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930
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G |
Foxa2 |
forkhead box A2 |
increases expression |
EXP |
Ketoconazole results in increased expression of FOXA2 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 3:135,470,123...135,474,326
Ensembl chr 3:135,470,131...135,474,326
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|
G |
Foxl2 |
forkhead box L2 |
increases expression |
ISO |
Ketoconazole results in increased expression of FOXL2 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 8:99,512,971...99,514,500
Ensembl chr 8:99,513,303...99,514,427
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|
G |
Foxp2 |
forkhead box P2 |
increases expression |
EXP |
Ketoconazole results in increased expression of FOXP2 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr 4:43,133,827...43,712,442
Ensembl chr 4:43,133,912...43,711,683
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|
G |
Fscn1 |
fascin actin-bundling protein 1 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of FSCN1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr12:11,597,042...11,610,183
Ensembl chr12:11,597,048...11,610,211
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|
G |
Fshb |
follicle stimulating hormone subunit beta |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [FSHB protein results in increased expression of DRD4 mRNA]; Ketoconazole inhibits the reaction [FSHB protein results in increased expression of EPPIN mRNA]; Ketoconazole inhibits the reaction [FSHB protein results in increased expression of GPD1 mRNA]; Ketoconazole inhibits the reaction [FSHB protein results in increased expression of RHOX5 mRNA] |
CTD |
PMID:19587329 |
|
NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
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|
G |
Fyco1 |
FYVE and coiled-coil domain autophagy adaptor 1 |
increases expression decreases expression |
ISO EXP |
Ketoconazole results in increased expression of FYCO1 mRNA Ketoconazole results in decreased expression of FYCO1 mRNA |
CTD |
PMID:36621641 PMID:36653537 |
|
NCBI chr 8:123,412,105...123,479,315
Ensembl chr 8:123,412,112...123,479,021
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|
G |
G0s2 |
G0/G1switch 2 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of G0S2 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr13:104,806,351...104,807,263
Ensembl chr13:104,806,156...104,807,451
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|
G |
G6pc1 |
glucose-6-phosphatase catalytic subunit 1 |
affects expression |
EXP |
Ketoconazole affects the expression of G6PC1 mRNA |
CTD |
PMID:18289764 |
|
NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804
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|
G |
G6pd |
glucose-6-phosphate dehydrogenase |
increases expression |
ISO |
Ketoconazole results in increased expression of G6PD mRNA |
CTD |
PMID:25399406 |
|
NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
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|
G |
Gabarapl2 |
GABA type A receptor associated protein like 2 |
increases expression |
EXP |
Ketoconazole results in increased expression of GABARAPL2 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr19:39,910,572...39,921,408
Ensembl chr19:39,910,534...39,924,628 Ensembl chr 8:39,910,534...39,924,628
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|
G |
Gabbr1 |
gamma-aminobutyric acid type B receptor subunit 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of GABBR1 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr20:1,464,534...1,494,114
Ensembl chr20:1,464,534...1,493,994
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|
G |
Gabbr2 |
gamma-aminobutyric acid type B receptor subunit 2 |
increases expression |
EXP |
Ketoconazole results in increased expression of GABBR2 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 5:60,947,517...61,288,104
Ensembl chr 5:60,947,526...61,288,104
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|
G |
Gabra4 |
gamma-aminobutyric acid type A receptor subunit alpha 4 |
increases expression |
EXP |
Ketoconazole results in increased expression of GABRA4 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr14:36,590,782...36,667,724
Ensembl chr14:36,590,782...36,665,844
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|
G |
Gabra5 |
gamma-aminobutyric acid type A receptor subunit alpha 5 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of GABRA5 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 1:108,268,728...108,381,670
Ensembl chr 1:108,268,776...108,380,917
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|
G |
Gabrd |
gamma-aminobutyric acid type A receptor subunit delta |
increases expression |
EXP |
Ketoconazole results in increased expression of GABRD mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 5:165,958,508...165,970,407
Ensembl chr 5:165,958,484...165,970,411
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|
G |
Gabre |
gamma-aminobutyric acid type A receptor subunit epsilon |
decreases expression |
EXP |
Ketoconazole results in decreased expression of GABRE mRNA |
CTD |
PMID:37077353 |
|
NCBI chr X:150,060,035...150,078,773
Ensembl chr X:150,060,040...150,078,693
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|
G |
Gabrq |
gamma-aminobutyric acid type A receptor subunit theta |
decreases expression |
EXP |
Ketoconazole results in decreased expression of GABRQ mRNA |
CTD |
PMID:37077353 |
|
NCBI chr X:150,696,161...150,712,948
Ensembl chr X:150,696,427...150,709,919
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|
G |
Gad1 |
glutamate decarboxylase 1 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of GAD1 mRNA |
CTD |
PMID:31099283 |
|
NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333
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|
G |
Gadd45a |
growth arrest and DNA-damage-inducible, alpha |
increases expression |
EXP |
Ketoconazole results in increased expression of GADD45A mRNA |
CTD |
PMID:16483768 |
|
NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
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|
G |
Gapdh |
glyceraldehyde-3-phosphate dehydrogenase |
increases expression |
EXP |
Ketoconazole results in increased expression of GAPDH mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
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|
G |
Gata3 |
GATA binding protein 3 |
increases expression |
EXP |
Ketoconazole results in increased expression of GATA3 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391
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|
G |
Gck |
glucokinase |
decreases expression |
EXP |
Ketoconazole results in decreased expression of GCK mRNA |
CTD |
PMID:37077353 |
|
NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995
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|
G |
Gckr |
glucokinase regulator |
affects expression |
EXP |
Ketoconazole affects the expression of GCKR mRNA |
CTD |
PMID:18355885 |
|
NCBI chr 6:25,044,592...25,075,834
Ensembl chr 6:25,045,100...25,075,654
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|
G |
Gdi2 |
GDP dissociation inhibitor 2 |
increases expression |
ISO |
Ketoconazole results in increased expression of GDI2 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr17:66,649,616...66,676,299
Ensembl chr17:66,649,619...66,676,366
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G |
Gdpd3 |
glycerophosphodiester phosphodiesterase domain containing 3 |
increases expression |
ISO |
Ketoconazole results in increased expression of GDPD3 mRNA |
CTD |
PMID:15342952 PMID:17175557 |
|
NCBI chr 1:181,373,505...181,383,063
Ensembl chr 1:181,366,626...181,383,063
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|
G |
Gfus |
GDP-L-fucose synthase |
increases expression |
ISO |
Ketoconazole results in increased expression of GFUS mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 7:107,612,087...107,617,005
Ensembl chr 7:107,612,094...107,616,948
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|
G |
Ghr |
growth hormone receptor |
decreases expression |
EXP |
Ketoconazole results in decreased expression of GHR mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 2:52,541,452...52,804,960
Ensembl chr 2:52,542,594...52,804,735
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|
G |
Gjb1 |
gap junction protein, beta 1 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of GJB1 mRNA |
CTD |
PMID:31099283 |
|
NCBI chr X:66,501,848...66,509,783
Ensembl chr X:66,501,820...66,509,925
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G |
Gjb2 |
gap junction protein, beta 2 |
increases expression |
EXP |
Ketoconazole results in increased expression of GJB2 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr15:31,260,390...31,278,222
Ensembl chr15:31,260,357...31,278,177
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|
G |
Gls2 |
glutaminase 2 |
affects expression |
EXP |
Ketoconazole affects the expression of GLS2 mRNA |
CTD |
PMID:18355885 |
|
NCBI chr 7:617,252...633,424
Ensembl chr 7:617,288...633,426
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|
G |
Gnai1 |
G protein subunit alpha i1 |
increases expression |
EXP |
Ketoconazole results in increased expression of GNAI1 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 4:16,814,000...16,898,119
Ensembl chr 4:16,814,001...16,896,417
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|
G |
Gng11 |
G protein subunit gamma 11 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of GNG11 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 4:32,023,003...32,028,443
Ensembl chr 4:32,023,003...32,028,442
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|
G |
Gnl3 |
G protein nucleolar 3 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of GNL3 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr16:6,207,402...6,213,491
Ensembl chr16:6,207,402...6,213,392
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|
G |
Gnrh1 |
gonadotropin releasing hormone 1 |
affects secretion |
EXP |
Ketoconazole affects the secretion of GNRH1 protein |
CTD |
PMID:37077353 |
|
NCBI chr15:41,972,482...41,976,690
Ensembl chr15:41,972,905...41,973,581 Ensembl chr15:41,972,905...41,973,581
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|
G |
Golga3 |
golgin A3 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of GOLGA3 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr12:46,452,409...46,500,509
Ensembl chr12:46,454,870...46,500,509
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|
G |
Golm1 |
golgi membrane protein 1 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of GOLM1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr17:4,995,925...5,044,329
Ensembl chr17:4,996,104...5,034,057
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|
G |
Golph3l |
golgi phosphoprotein 3-like |
decreases expression |
ISO |
Ketoconazole results in decreased expression of GOLPH3L mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 2:183,151,941...183,183,094
Ensembl chr 2:183,153,301...183,183,083
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G |
Got1 |
glutamic-oxaloacetic transaminase 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of GOT1 protein |
CTD |
PMID:31099283 |
|
NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
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G |
Got2 |
glutamic-oxaloacetic transaminase 2 |
affects expression |
EXP |
Ketoconazole affects the expression of GOT2 mRNA |
CTD |
PMID:18355885 |
|
NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994
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|
G |
Gpam |
glycerol-3-phosphate acyltransferase, mitochondrial |
decreases expression |
EXP |
Ketoconazole results in decreased expression of GPAM mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639
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|
G |
Gpatch2 |
G patch domain containing 2 |
increases expression |
ISO |
Ketoconazole results in increased expression of GPATCH2 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr13:98,784,993...98,925,696
Ensembl chr13:98,784,969...98,925,661
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G |
Gpd1 |
glycerol-3-phosphate dehydrogenase 1 |
multiple interactions decreases expression increases expression |
ISO EXP |
Ketoconazole inhibits the reaction [FSHB protein results in increased expression of GPD1 mRNA]; Metribolone inhibits the reaction [Ketoconazole results in decreased expression of GPD1 mRNA] Ketoconazole results in increased expression of GPD1 mRNA |
CTD |
PMID:19587329 PMID:37077353 |
|
NCBI chr 7:130,842,526...130,851,530
Ensembl chr 7:130,844,138...130,851,529
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|
G |
Gpr12 |
G protein-coupled receptor 12 |
increases expression |
EXP |
Ketoconazole results in increased expression of GPR12 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr12:8,522,709...8,525,875
Ensembl chr12:8,522,953...8,527,973
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|
G |
Gpr17 |
G protein-coupled receptor 17 |
decreases expression increases expression |
EXP |
Ketoconazole results in decreased expression of GPR17 mRNA Ketoconazole results in increased expression of GPR17 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr18:23,576,232...23,583,153
Ensembl chr18:23,577,242...23,582,966
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|
G |
Gpr37 |
G protein-coupled receptor 37 |
increases expression |
EXP |
Ketoconazole results in increased expression of GPR37 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 4:54,138,860...54,160,927
Ensembl chr 4:54,138,870...54,161,001
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|
G |
Gpr6 |
G protein-coupled receptor 6 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of GPR6 mRNA |
CTD |
PMID:31099283 |
|
NCBI chr20:44,489,853...44,492,624
Ensembl chr20:44,489,853...44,492,624
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|
G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions increases expression |
EXP ISO |
Ketoconazole inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein] Ketoconazole inhibits the reaction [columbin results in increased activity of GPT protein]; Ketoconazole promotes the reaction [gelsemine results in increased expression of GPT protein] Ketoconazole results in increased expression of GPT protein |
CTD |
PMID:31099283 PMID:31168027 PMID:32162908 PMID:34627953 |
|
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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|
G |
Gpx4 |
glutathione peroxidase 4 |
increases expression |
EXP |
Ketoconazole results in increased expression of GPX4 mRNA |
CTD |
PMID:17679765 |
|
NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
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|
G |
Grb14 |
growth factor receptor bound protein 14 |
affects expression |
EXP |
Ketoconazole affects the expression of GRB14 mRNA |
CTD |
PMID:18355885 |
|
NCBI chr 3:49,568,210...49,683,805
Ensembl chr 3:49,568,210...49,683,889
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|
G |
Greb1 |
growth regulating estrogen receptor binding 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of GREB1 mRNA |
CTD |
PMID:35307500 |
|
NCBI chr 6:39,440,522...39,562,364
Ensembl chr 6:39,440,504...39,581,633
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|
G |
Grid2ip |
Grid2 interacting protein |
increases expression |
EXP |
Ketoconazole results in increased expression of GRID2IP mRNA |
CTD |
PMID:37077353 |
|
NCBI chr12:11,166,567...11,203,765
Ensembl chr12:11,167,874...11,203,676
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|
G |
Grik2 |
glutamate ionotropic receptor kainate type subunit 2 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of GRIK2 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr20:52,135,325...52,833,061
Ensembl chr20:52,133,851...52,838,375
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|
G |
Grina |
glutamate ionotropic receptor NMDA type subunit associated protein 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of GRINA mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 7:107,962,194...107,965,372
Ensembl chr 7:107,962,207...107,965,366
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|
G |
Grm3 |
glutamate metabotropic receptor 3 |
increases expression |
EXP |
Ketoconazole results in increased expression of GRM3 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 4:24,364,854...24,643,972
Ensembl chr 4:24,365,115...24,609,804
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|
G |
Grm4 |
glutamate metabotropic receptor 4 |
affects expression |
EXP |
Ketoconazole affects the expression of GRM4 mRNA |
CTD |
PMID:37077353 |
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NCBI chr20:5,484,172...5,572,821
Ensembl chr20:5,481,124...5,572,821
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G |
Gsr |
glutathione-disulfide reductase |
increases expression multiple interactions |
EXP |
Ketoconazole results in increased expression of GSR mRNA [Ketoconazole co-treated with Carbon Tetrachloride] results in increased expression of GSR mRNA |
CTD |
PMID:31168027 |
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NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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G |
Gsta1 |
glutathione S-transferase alpha 1 |
multiple interactions decreases expression |
ISO EXP |
Ketoconazole inhibits the reaction [Phenobarbital results in increased expression of GSTA1 mRNA]; Ketoconazole inhibits the reaction [Rifampin results in increased expression of GSTA1 mRNA] Ketoconazole results in decreased expression of GSTA1 mRNA Ketoconazole inhibits the reaction [Carbon Tetrachloride results in decreased expression of GSTA1 mRNA]; Ketoconazole inhibits the reaction [Genistein results in increased expression of GSTA1 mRNA] |
CTD |
PMID:16608920 PMID:31168027 PMID:32185415 |
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NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
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G |
Gsta2 |
glutathione S-transferase alpha 2 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of GSTA2 mRNA |
CTD |
PMID:16608920 |
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NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
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G |
Gstm1 |
glutathione S-transferase mu 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of GSTM1 protein |
CTD |
PMID:17966066 |
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NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
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G |
Gstm2 |
glutathione S-transferase mu 2 |
affects expression |
EXP |
Ketoconazole affects the expression of GSTM2 mRNA |
CTD |
PMID:18289764 |
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NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961
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G |
Gstp1 |
glutathione S-transferase pi 1 |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac]; Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac] |
CTD |
PMID:24246759 |
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NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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G |
Gtpbp8 |
GTP binding protein 8 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of GTPBP8 mRNA |
CTD |
PMID:36621641 |
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NCBI chr11:55,945,778...55,955,743
Ensembl chr11:55,945,795...55,955,635
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G |
Gzf1 |
GDNF-inducible zinc finger protein 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of GZF1 mRNA |
CTD |
PMID:36653537 |
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NCBI chr 3:136,119,004...136,131,223
Ensembl chr 3:136,119,113...136,131,223
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G |
H6pd |
hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) |
decreases expression increases expression |
EXP ISO |
Ketoconazole results in decreased expression of H6PD mRNA Ketoconazole results in increased expression of H6PD mRNA |
CTD |
PMID:36621641 PMID:37077353 |
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NCBI chr 5:160,434,499...160,470,203
Ensembl chr 5:160,438,697...160,470,171
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G |
Hadha |
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha |
increases expression decreases expression |
EXP ISO |
Ketoconazole results in increased expression of HADHA mRNA Ketoconazole results in decreased expression of HADHA mRNA |
CTD |
PMID:36621641 PMID:37077353 |
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NCBI chr 6:26,187,969...26,227,605
Ensembl chr 6:26,187,956...26,227,869
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G |
Hadhb |
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta |
increases expression |
EXP |
Ketoconazole results in increased expression of HADHB mRNA |
CTD |
PMID:37077353 |
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NCBI chr 6:26,153,572...26,187,668
Ensembl chr 6:26,153,578...26,184,869
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G |
Hal |
histidine ammonia lyase |
affects expression |
EXP |
Ketoconazole affects the expression of HAL mRNA |
CTD |
PMID:18355885 |
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NCBI chr 7:28,007,449...28,037,701
Ensembl chr 7:28,006,972...28,037,701
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G |
Hamp |
hepcidin antimicrobial peptide |
multiple interactions decreases expression |
ISO |
Ketoconazole inhibits the reaction [IL6 protein results in increased expression of HAMP mRNA] Ketoconazole results in decreased expression of HAMP protein |
CTD |
PMID:17966066 |
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NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891
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G |
Has2 |
hyaluronan synthase 2 |
increases expression |
ISO |
Ketoconazole results in increased expression of HAS2 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 7:88,113,326...88,139,337
Ensembl chr 7:88,113,326...88,128,933
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G |
Havcr1 |
hepatitis A virus cellular receptor 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of HAVCR1 mRNA |
CTD |
PMID:18289764 |
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NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
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G |
Hbb |
hemoglobin subunit beta |
decreases expression |
EXP |
Ketoconazole results in decreased expression of HBB mRNA; Ketoconazole results in decreased expression of HBB-B1 mRNA |
CTD |
PMID:36653537 |
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NCBI chr 1:158,250,421...158,251,832
Ensembl chr 1:158,120,200...158,252,012
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G |
Hebp1 |
heme binding protein 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of HEBP1 mRNA |
CTD |
PMID:37077353 |
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NCBI chr 4:167,974,316...168,003,854
Ensembl chr 4:167,974,319...168,003,854
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G |
Hes6 |
hes family bHLH transcription factor 6 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of HES6 mRNA |
CTD |
PMID:36653537 |
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NCBI chr 9:92,001,849...92,003,562
Ensembl chr 9:92,001,841...92,003,559
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G |
Hibadh |
3-hydroxyisobutyrate dehydrogenase |
increases expression |
ISO |
Ketoconazole results in increased expression of HIBADH mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 4:81,649,180...81,747,244
Ensembl chr 4:81,649,175...81,780,617
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G |
Hif1an |
hypoxia inducible factor 1 subunit alpha inhibitor |
increases expression |
ISO |
Ketoconazole results in increased expression of HIF1AN mRNA |
CTD |
PMID:31099283 |
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NCBI chr 1:243,419,175...243,440,464
Ensembl chr 1:243,419,194...243,434,327
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G |
Hist1h4b |
histone cluster 1 H4 family member B |
decreases expression |
EXP |
Ketoconazole results in decreased expression of HIST1H4B mRNA |
CTD |
PMID:36653537 |
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NCBI chr17:42,480,467...42,484,912
Ensembl chr17:42,480,313...42,485,370
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G |
Hivep1 |
HIVEP zinc finger 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of HIVEP1 mRNA |
CTD |
PMID:36621641 |
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NCBI chr17:22,585,016...22,714,517
Ensembl chr17:22,585,016...22,711,956
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G |
Hmga2 |
high mobility group AT-hook 2 |
increases expression |
ISO |
Ketoconazole results in increased expression of HMGA2 mRNA |
CTD |
PMID:31099283 |
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NCBI chr 7:55,877,145...55,998,813
Ensembl chr 7:55,880,112...55,994,784
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G |
Hmgb2 |
high mobility group box 2 |
affects expression |
EXP |
Ketoconazole affects the expression of HMGB2 mRNA |
CTD |
PMID:18355885 |
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NCBI chr16:32,710,651...32,713,230
Ensembl chr16:32,710,658...32,713,140
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G |
Hmgcr |
3-hydroxy-3-methylglutaryl-CoA reductase |
increases activity multiple interactions decreases activity decreases expression increases expression |
EXP ISO |
Ketoconazole results in increased activity of HMGCR protein [Colforsin co-treated with Ketoconazole] results in decreased expression of HMGCR mRNA Ketoconazole results in decreased activity of HMGCR protein Ketoconazole results in decreased expression of HMGCR mRNA Ketoconazole results in increased expression of HMGCR mRNA |
CTD |
PMID:9199277 PMID:12617470 PMID:16935330 PMID:28263823 PMID:37077353 |
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NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
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G |
Hmgcs1 |
3-hydroxy-3-methylglutaryl-CoA synthase 1 |
increases expression |
EXP ISO |
Ketoconazole results in increased expression of HMGCS1 mRNA |
CTD |
PMID:28263823 PMID:31099283 |
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NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
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G |
Hmgcs2 |
3-hydroxy-3-methylglutaryl-CoA synthase 2 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of HMGCS2 mRNA |
CTD |
PMID:31099283 |
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NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130
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G |
Hmox1 |
heme oxygenase 1 |
affects expression multiple interactions increases expression |
EXP ISO |
Ketoconazole affects the expression of HMOX1 mRNA Ketoconazole inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 protein] [Ketoconazole co-treated with Carbon Tetrachloride] results in increased expression of HMOX1 protein; Ketoconazole inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA] Ketoconazole results in increased expression of HMOX1 mRNA |
CTD |
PMID:12763371 PMID:18289764 PMID:22659318 PMID:31168027 PMID:37077353 |
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Hormad1 |
HORMA domain containing 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of HORMAD1 mRNA |
CTD |
PMID:36653537 |
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NCBI chr 2:183,115,815...183,152,383
Ensembl chr 2:183,116,716...183,152,383
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G |
Hoxa4 |
homeo box A4 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of HOXA4 mRNA |
CTD |
PMID:31099283 |
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NCBI chr 4:81,289,677...81,291,685
Ensembl chr 4:81,289,682...81,291,685
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G |
Hpn |
hepsin |
increases expression |
ISO |
Ketoconazole results in increased expression of HPN mRNA |
CTD |
PMID:15342952 |
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NCBI chr 1:86,337,085...86,352,785
Ensembl chr 1:86,337,087...86,352,811
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G |
Hras |
HRas proto-oncogene, GTPase |
decreases expression |
ISO |
Ketoconazole results in decreased expression of HRAS mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
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G |
Hsd11b2 |
hydroxysteroid 11-beta dehydrogenase 2 |
decreases activity |
ISO |
Ketoconazole results in decreased activity of HSD11B2 protein |
CTD |
PMID:10664531 |
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NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899
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G |
Hsd17b2 |
hydroxysteroid (17-beta) dehydrogenase 2 |
multiple interactions |
ISO |
Ketoconazole promotes the reaction [Calcitriol results in increased expression of HSD17B2 mRNA] |
CTD |
PMID:12040012 |
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NCBI chr19:45,753,576...45,825,203
Ensembl chr19:45,753,574...45,825,202
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G |
Hsd17b4 |
hydroxysteroid (17-beta) dehydrogenase 4 |
multiple interactions increases expression |
ISO |
Ketoconazole promotes the reaction [Colforsin results in increased expression of HSD17B4 mRNA] Ketoconazole results in increased expression of HSD17B4 mRNA |
CTD |
PMID:16935330 |
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NCBI chr18:43,328,903...43,417,950
Ensembl chr18:43,328,824...43,417,952
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G |
Hsd17b7 |
hydroxysteroid (17-beta) dehydrogenase 7 |
increases expression |
EXP |
Ketoconazole results in increased expression of HSD17B7 mRNA |
CTD |
PMID:28263823 |
|
NCBI chr13:82,170,079...82,190,018
Ensembl chr13:82,173,179...82,190,017
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G |
Hsd3b1 |
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of HSD3B1 mRNA |
CTD |
PMID:17229994 |
|
NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999
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G |
Hsd3b2 |
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 |
multiple interactions decreases expression |
ISO |
[Colforsin co-treated with Ketoconazole] results in decreased expression of HSD3B2 mRNA Ketoconazole results in decreased expression of HSD3B2 mRNA |
CTD |
PMID:16935330 |
|
NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852
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G |
Hspd1 |
heat shock protein family D (Hsp60) member 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of HSPD1 mRNA |
CTD |
PMID:25787151 |
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NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
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G |
Hyal2 |
hyaluronidase 2 |
increases expression |
ISO |
Ketoconazole results in increased expression of HYAL2 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 8:108,241,895...108,246,853
Ensembl chr 8:108,243,133...108,246,850
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G |
Hycc1 |
hyccin PI4KA lipid kinase complex subunit 1 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of HYCC1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 4:11,132,224...11,239,120
Ensembl chr 4:11,132,385...11,239,113
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G |
Ibsp |
integrin-binding sialoprotein |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [Calcifediol results in increased expression of IBSP mRNA] |
CTD |
PMID:21542014 |
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NCBI chr14:5,439,825...5,452,570
Ensembl chr14:5,439,829...5,452,693
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G |
Id4 |
inhibitor of DNA binding 4 |
increases expression |
ISO |
Ketoconazole results in increased expression of ID4 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr17:16,389,387...16,391,956
Ensembl chr17:16,389,387...16,392,470
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G |
Idi1 |
isopentenyl-diphosphate delta isomerase 1 |
increases expression multiple interactions |
ISO EXP |
Ketoconazole results in increased expression of IDI1 mRNA EIF2S1 protein mutant form promotes the reaction [Ketoconazole results in increased expression of IDI1 mRNA] |
CTD |
PMID:16330322 PMID:28263823 |
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NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357
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G |
Ifih1 |
interferon induced with helicase C domain 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of IFIH1 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr 3:47,228,980...47,275,403
Ensembl chr 3:47,227,364...47,275,456
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G |
Igfbp1 |
insulin-like growth factor binding protein 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of IGFBP1 mRNA |
CTD |
PMID:18289764 |
|
NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482
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G |
Igfbp5 |
insulin-like growth factor binding protein 5 |
increases expression |
EXP |
Ketoconazole results in increased expression of IGFBP5 mRNA |
CTD |
PMID:36653537 PMID:37077353 |
|
NCBI chr 9:74,452,371...74,464,953
Ensembl chr 9:74,448,382...74,465,156
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G |
Igfbp6 |
insulin-like growth factor binding protein 6 |
increases expression |
EXP |
Ketoconazole results in increased expression of IGFBP6 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 7:133,276,309...133,280,944
Ensembl chr 7:133,276,234...133,280,966
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G |
Igfbp7 |
insulin-like growth factor binding protein 7 |
increases expression |
EXP |
Ketoconazole results in increased expression of IGFBP7 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr14:30,737,414...30,797,317
Ensembl chr14:30,737,164...30,797,314
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G |
Ighe |
immunoglobulin heavy constant epsilon |
multiple interactions |
ISO |
Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [IL4 protein results in increased expression of IGHE mRNA alternative form]]; Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [IL4 protein results in increased expression of IGHE mRNA]]; Ketoconazole inhibits the reaction [IL4 protein results in increased expression of IGHE mRNA alternative form]; Ketoconazole inhibits the reaction [IL4 protein results in increased expression of IGHE mRNA] |
CTD |
PMID:12230500 |
|
|
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G |
Igkc |
immunoglobulin kappa constant |
decreases expression |
EXP |
Ketoconazole results in decreased expression of IGKC mRNA |
CTD |
PMID:18289764 |
|
|
|
G |
Igsf10 |
immunoglobulin superfamily, member 10 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of IGSF10 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 2:143,575,710...143,605,044
Ensembl chr 2:143,576,070...143,604,773
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G |
Ihh |
Indian hedgehog signaling molecule |
increases expression |
EXP |
Ketoconazole results in increased expression of IHH mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 9:76,504,315...76,510,532
Ensembl chr 9:76,504,315...76,510,532
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G |
Il1a |
interleukin 1 alpha |
increases expression |
ISO |
Ketoconazole results in increased expression of IL1A mRNA |
CTD |
PMID:32816093 |
|
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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G |
Il1b |
interleukin 1 beta |
multiple interactions increases expression |
ISO EXP |
Ketoconazole inhibits the reaction [[IL1B protein co-treated with IL6 protein] results in increased expression of SAA1 mRNA]; Ketoconazole inhibits the reaction [[IL1B protein co-treated with IL6 protein] results in increased expression of SAA2 mRNA]; Ketoconazole promotes the reaction [gelsemine results in increased expression of IL1B protein] Ketoconazole results in increased expression of IL1B mRNA Ketoconazole inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B protein] |
CTD |
PMID:17966066 PMID:28138970 PMID:31168027 PMID:32816093 PMID:34627953 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il1rl1 |
interleukin 1 receptor-like 1 |
multiple interactions |
ISO |
Ketoconazole promotes the reaction [Calcitriol results in increased expression of IL1RL1 mRNA] |
CTD |
PMID:12040012 |
|
NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256
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G |
Il24 |
interleukin 24 |
increases expression |
ISO |
Ketoconazole results in increased expression of IL24 mRNA |
CTD |
PMID:32816093 |
|
NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487
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G |
Il33 |
interleukin 33 |
affects expression increases expression |
EXP |
Ketoconazole affects the expression of IL33 mRNA Ketoconazole results in increased expression of IL33 mRNA |
CTD |
PMID:18355885 PMID:37077353 |
|
NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373
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G |
Il4 |
interleukin 4 |
multiple interactions decreases secretion decreases expression |
ISO |
1-Methyl-3-isobutylxanthine inhibits the reaction [Ketoconazole results in decreased expression of IL4 mRNA]; 1-Methyl-3-isobutylxanthine inhibits the reaction [Ketoconazole results in decreased secretion of IL4 protein]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [IL4 protein results in increased expression of IGHE mRNA alternative form]]; Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [IL4 protein results in increased expression of IGHE mRNA]]; Bucladesine inhibits the reaction [Ketoconazole results in decreased expression of IL4 mRNA]; Bucladesine inhibits the reaction [Ketoconazole results in decreased secretion of IL4 protein]; Colforsin inhibits the reaction [Ketoconazole results in decreased expression of IL4 mRNA]; Colforsin inhibits the reaction [Ketoconazole results in decreased secretion of IL4 protein]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2]; Ketoconazole inhibits the reaction [IL4 protein results in increased chemical synthesis of Cyclic AMP]; Ketoconazole inhibits the reaction [IL4 protein results in increased expression of IGHE mRNA alternative form]; Ketoconazole inhibits the reaction [IL4 protein results in increased expression of IGHE mRNA]; Ketoconazole promotes the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprostone] |
CTD |
PMID:11886533 PMID:12230500 PMID:15284827 PMID:23688403 |
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NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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G |
Il5 |
interleukin 5 |
multiple interactions decreases expression decreases secretion |
ISO |
1-Methyl-3-isobutylxanthine inhibits the reaction [Ketoconazole results in decreased expression of IL5 mRNA]; 1-Methyl-3-isobutylxanthine inhibits the reaction [Ketoconazole results in decreased secretion of IL5 protein]; Bucladesine inhibits the reaction [Ketoconazole results in decreased expression of IL5 mRNA]; Bucladesine inhibits the reaction [Ketoconazole results in decreased secretion of IL5 protein]; Colforsin inhibits the reaction [Ketoconazole results in decreased expression of IL5 mRNA]; Colforsin inhibits the reaction [Ketoconazole results in decreased secretion of IL5 protein] |
CTD |
PMID:11886533 PMID:15284827 |
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NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO EXP |
Ketoconazole inhibits the reaction [[IL1B protein co-treated with IL6 protein] results in increased expression of SAA1 mRNA]; Ketoconazole inhibits the reaction [[IL1B protein co-treated with IL6 protein] results in increased expression of SAA2 mRNA]; Ketoconazole inhibits the reaction [IL6 protein results in increased expression of HAMP mRNA] Ketoconazole inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein] |
CTD |
PMID:17966066 PMID:31168027 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Ing1 |
inhibitor of growth family, member 1 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of ING1 mRNA |
CTD |
PMID:36621641 |
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NCBI chr16:77,937,276...77,945,320
Ensembl chr16:77,937,279...77,946,264
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G |
Ing2 |
inhibitor of growth family, member 2 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of ING2 mRNA |
CTD |
PMID:36621641 |
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NCBI chr16:44,573,592...44,584,180
Ensembl chr16:44,575,597...44,583,482
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G |
Inhbe |
inhibin subunit beta E |
increases expression |
ISO |
Ketoconazole results in increased expression of INHBE mRNA |
CTD |
PMID:15342952 PMID:17175557 PMID:17567588 |
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NCBI chr 7:63,176,221...63,179,209
Ensembl chr 7:63,176,219...63,179,172
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G |
Inip |
INTS3 and NABP interacting protein |
increases expression |
EXP |
Ketoconazole results in increased expression of INIP mRNA |
CTD |
PMID:36653537 |
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NCBI chr 5:74,648,392...74,662,628
Ensembl chr 5:74,648,392...74,662,628
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G |
Insig1 |
insulin induced gene 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of INSIG1 mRNA |
CTD |
PMID:37077353 |
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NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952
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G |
Insl3 |
insulin-like 3 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of INSL3 mRNA |
CTD |
PMID:36653537 |
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NCBI chr16:18,398,682...18,400,566
Ensembl chr16:18,384,829...18,400,560
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G |
Insr |
insulin receptor |
decreases expression |
EXP |
Ketoconazole results in decreased expression of INSR mRNA |
CTD |
PMID:37077353 |
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NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
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G |
Ipo5 |
importin 5 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of IPO5 mRNA |
CTD |
PMID:36621641 |
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NCBI chr15:97,990,755...98,041,074
Ensembl chr15:98,005,299...98,041,126
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G |
Ipo7 |
importin 7 |
increases expression |
ISO |
Ketoconazole results in increased expression of IPO7 mRNA |
CTD |
PMID:36621641 |
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NCBI chr 1:164,062,702...164,102,938
Ensembl chr 1:164,062,702...164,102,938
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G |
Irs1 |
insulin receptor substrate 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of IRS1 mRNA |
CTD |
PMID:37077353 |
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NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
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G |
Itpr1 |
inositol 1,4,5-trisphosphate receptor, type 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of ITPR1 mRNA |
CTD |
PMID:37077353 |
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NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491
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G |
Ivd |
isovaleryl-CoA dehydrogenase |
increases expression |
EXP |
Ketoconazole results in increased expression of IVD mRNA |
CTD |
PMID:37077353 |
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NCBI chr 3:105,851,710...105,872,144
Ensembl chr 3:105,851,683...105,872,575
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G |
Kcmf1 |
potassium channel modulatory factor 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of KCMF1 mRNA |
CTD |
PMID:36621641 |
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NCBI chr 4:104,888,452...104,950,234
Ensembl chr 4:104,889,847...104,950,234
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G |
Kcna5 |
potassium voltage-gated channel subfamily A member 5 |
decreases activity |
ISO |
Ketoconazole results in decreased activity of KCNA5 protein |
CTD |
PMID:9694927 |
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NCBI chr 4:159,354,689...159,358,173
Ensembl chr 4:159,350,097...159,357,697
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G |
Kcne2 |
potassium voltage-gated channel subfamily E regulatory subunit 2 |
increases expression |
EXP |
Ketoconazole results in increased expression of KCNE2 mRNA |
CTD |
PMID:36653537 |
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NCBI chr11:31,517,176...31,530,026
Ensembl chr11:31,295,614...31,530,043
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G |
Kcnh1 |
potassium voltage-gated channel subfamily H member 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of KCNH1 mRNA |
CTD |
PMID:36653537 |
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NCBI chr13:103,722,140...104,024,762
Ensembl chr13:103,722,245...104,024,740
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G |
Kcnh2 |
potassium voltage-gated channel subfamily H member 2 |
affects activity affects localization decreases activity multiple interactions decreases response to substance |
ISO |
Ketoconazole affects the activity of KCNH2 protein mutant form Ketoconazole affects the localization of KCNH2; Ketoconazole affects the localization of KCNH2 protein mutant form Ketoconazole results in decreased activity of KCNH2; Ketoconazole results in decreased activity of KCNH2 protein [Ketoconazole co-treated with desloratadine co-treated with Loratadine] results in decreased activity of KCNH2 protein; [Ketoconazole co-treated with desloratadine] results in decreased activity of KCNH2 protein; [Ketoconazole co-treated with Loratadine] results in decreased activity of KCNH2 protein; Ketoconazole binds to and results in decreased activity of KCNH2 protein; Terfenadine promotes the reaction [Ketoconazole results in decreased activity of KCNH2 protein] KCNH2 protein mutant form results in decreased susceptibility to Ketoconazole |
CTD |
PMID:9694927 PMID:15272206 PMID:16542653 PMID:17965736 PMID:24052561 PMID:29143966 More...
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NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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G |
Kctd12 |
potassium channel tetramerization domain containing 12 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of KCTD12 mRNA |
CTD |
PMID:37077353 |
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NCBI chr15:79,800,078...79,806,017
Ensembl chr15:79,801,191...79,806,282
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G |
Kctd12b |
potassium channel tetramerisation domain containing 12b |
decreases expression |
EXP |
Ketoconazole results in decreased expression of KCTD12B mRNA |
CTD |
PMID:37077353 |
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NCBI chr X:17,643,707...17,654,820
Ensembl chr X:17,643,615...17,654,820
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G |
Kdm2b |
lysine demethylase 2B |
affects expression |
ISO |
Ketoconazole affects the expression of KDM2B mRNA |
CTD |
PMID:36621641 |
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NCBI chr12:33,566,530...33,701,366
Ensembl chr12:33,574,657...33,701,355
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G |
Kdm3a |
lysine demethylase 3A |
increases expression |
EXP |
Ketoconazole results in increased expression of KDM3A mRNA |
CTD |
PMID:36653537 |
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NCBI chr 4:103,630,907...103,675,073
Ensembl chr 4:103,630,908...103,675,073
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G |
Keap1 |
Kelch-like ECH-associated protein 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of KEAP1 mRNA |
CTD |
PMID:37077353 |
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NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
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G |
Klf11 |
KLF transcription factor 11 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of KLF11 mRNA |
CTD |
PMID:37077353 |
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NCBI chr 6:41,285,699...41,297,548
Ensembl chr 6:41,285,842...41,297,550
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G |
Klk1 |
kallikrein 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of KLK1 mRNA |
CTD |
PMID:31099283 |
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NCBI chr 1:94,642,644...94,646,760
Ensembl chr 1:94,642,687...94,646,754
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G |
Klk1c10 |
kallikrein 1-related peptidase C10 |
multiple interactions |
ISO |
[Goserelin co-treated with Dutasteride co-treated with bicalutamide co-treated with Ketoconazole] results in decreased expression of KLK3 protein |
CTD |
PMID:24323034 |
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NCBI chr 1:94,402,993...94,407,052
Ensembl chr 1:94,402,993...94,407,052
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G |
Klk6 |
kallikrein related-peptidase 6 |
multiple interactions increases expression |
ISO EXP |
Ketoconazole promotes the reaction [Calcitriol results in increased expression of KLK6 mRNA] Ketoconazole results in increased expression of KLK6 mRNA |
CTD |
PMID:26485663 PMID:37077353 |
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NCBI chr 1:94,278,863...94,286,136
Ensembl chr 1:94,280,340...94,286,121
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G |
Kpna3 |
karyopherin subunit alpha 3 |
increases expression |
ISO |
Ketoconazole results in increased expression of KPNA3 mRNA |
CTD |
PMID:36621641 |
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NCBI chr15:35,536,310...35,610,066
Ensembl chr15:35,536,316...35,610,419
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G |
Lamb3 |
laminin subunit beta 3 |
increases expression |
EXP |
Ketoconazole results in increased expression of LAMB3 mRNA |
CTD |
PMID:37077353 |
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NCBI chr13:104,833,810...104,875,405
Ensembl chr13:104,833,873...104,875,405
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G |
Laptm4a |
lysosomal protein transmembrane 4 alpha |
increases expression |
EXP |
Ketoconazole results in increased expression of LAPTM4A mRNA |
CTD |
PMID:37077353 |
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NCBI chr 6:31,719,287...31,737,023
Ensembl chr 6:31,718,976...31,737,020
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G |
Lcn2 |
lipocalin 2 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of LCN2 mRNA |
CTD |
PMID:18289764 |
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NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
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G |
Lhb |
luteinizing hormone subunit beta |
multiple interactions |
EXP |
Ketoconazole inhibits the reaction [LHB protein results in increased abundance of Testosterone] |
CTD |
PMID:7589908 |
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NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972 Ensembl chr 1:95,900,984...95,901,972
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G |
Lhcgr |
luteinizing hormone/choriogonadotropin receptor |
decreases expression |
EXP |
Ketoconazole results in decreased expression of LHCGR mRNA |
CTD |
PMID:36653537 |
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NCBI chr 6:5,661,871...5,728,109
Ensembl chr 6:5,661,871...5,724,521
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G |
Lhpp |
phospholysine phosphohistidine inorganic pyrophosphate phosphatase |
increases expression |
EXP |
Ketoconazole results in increased expression of LHPP mRNA |
CTD |
PMID:37077353 |
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NCBI chr 1:187,403,390...187,494,577
Ensembl chr 1:187,403,433...187,494,578
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G |
Lhx1 |
LIM homeobox 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of LHX1 mRNA |
CTD |
PMID:28263823 |
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NCBI chr10:69,396,829...69,403,617
Ensembl chr10:69,396,829...69,403,617
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G |
Lmnb1 |
lamin B1 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of LMNB1 mRNA |
CTD |
PMID:36621641 |
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NCBI chr18:50,175,861...50,215,210
Ensembl chr18:50,175,874...50,214,502
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G |
Lnpk |
lunapark, ER junction formation factor |
increases expression |
ISO |
Ketoconazole results in increased expression of LNPK mRNA |
CTD |
PMID:36621641 |
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NCBI chr 3:59,418,872...59,487,029
Ensembl chr 3:59,424,286...59,486,518
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G |
Lox |
lysyl oxidase |
affects expression |
EXP |
Ketoconazole affects the expression of LOX mRNA |
CTD |
PMID:18355885 |
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NCBI chr18:45,964,544...45,977,431
Ensembl chr18:45,967,343...46,041,477
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G |
Lrrc17 |
leucine rich repeat containing 17 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of LRRC17 mRNA |
CTD |
PMID:36621641 |
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NCBI chr 4:13,501,428...13,531,845
Ensembl chr 4:13,501,436...13,531,845
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G |
Lrrc28 |
leucine rich repeat containing 28 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of LRRC28 mRNA |
CTD |
PMID:36653537 |
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NCBI chr 1:121,116,833...121,245,805
Ensembl chr 1:121,127,733...121,245,784
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G |
Lrrc41 |
leucine rich repeat containing 41 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of LRRC41 mRNA |
CTD |
PMID:36621641 |
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NCBI chr 5:129,554,547...129,575,450
Ensembl chr 5:129,554,547...129,575,449
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G |
Lrrc75a |
leucine rich repeat containing 75A |
increases expression |
EXP |
Ketoconazole results in increased expression of LRRC75A mRNA |
CTD |
PMID:28263823 |
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NCBI chr10:47,298,222...47,343,301
Ensembl chr10:47,297,288...47,343,664
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G |
Lrrfip2 |
LRR binding FLII interacting protein 2 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of LRRFIP2 mRNA |
CTD |
PMID:36621641 |
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NCBI chr 8:111,091,453...111,193,947
Ensembl chr 8:111,091,503...111,193,255
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G |
Lsm5 |
LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated |
increases expression |
ISO |
Ketoconazole results in increased expression of LSM5 mRNA |
CTD |
PMID:36621641 |
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NCBI chr 4:85,951,073...85,954,289
Ensembl chr 6:104,652,477...104,654,165 Ensembl chr 4:104,652,477...104,654,165
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G |
Lss |
lanosterol synthase |
increases expression |
ISO |
Ketoconazole results in increased expression of LSS mRNA |
CTD |
PMID:15342952 PMID:17175557 PMID:17567588 |
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NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762
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G |
M6pr |
mannose-6-phosphate receptor, cation dependent |
decreases expression |
ISO |
Ketoconazole results in decreased expression of M6PR mRNA |
CTD |
PMID:36621641 |
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NCBI chr 4:155,501,080...155,510,219
Ensembl chr 4:155,500,921...155,510,216
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G |
Macroh2a1 |
macroH2A.1 histone |
affects expression |
EXP |
Ketoconazole affects the expression of MACROH2A1 mRNA |
CTD |
PMID:18355885 |
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NCBI chr17:8,479,331...8,542,071
Ensembl chr17:8,479,372...8,542,072
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G |
Madcam1 |
mucosal vascular addressin cell adhesion molecule 1 |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [TNF protein results in increased expression of MADCAM1 protein] |
CTD |
PMID:12388057 |
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NCBI chr 7:10,036,301...10,039,703
Ensembl chr 7:10,036,301...10,039,703
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G |
Malsu1 |
mitochondrial assembly of ribosomal large subunit 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of MALSU1 mRNA |
CTD |
PMID:36621641 |
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NCBI chr 4:78,051,090...78,059,913
Ensembl chr 4:78,051,059...78,059,905
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G |
Manba |
mannosidase beta |
affects expression |
EXP |
Ketoconazole affects the expression of MANBA mRNA |
CTD |
PMID:18355885 |
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NCBI chr 2:223,910,432...224,002,988
Ensembl chr 2:223,910,432...224,002,983
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G |
Map4k5 |
mitogen-activated protein kinase kinase kinase kinase 5 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of MAP4K5 mRNA |
CTD |
PMID:36621641 |
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NCBI chr 6:88,284,087...88,377,118
Ensembl chr 6:88,284,094...88,376,799
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G |
Mapk14 |
mitogen activated protein kinase 14 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of MAPK14 mRNA |
CTD |
PMID:36621641 |
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NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
increases phosphorylation increases expression |
ISO EXP |
Ketoconazole results in increased phosphorylation of MAPK8 protein Ketoconazole results in increased expression of MAPK8 mRNA |
CTD |
PMID:19631732 PMID:25787151 |
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NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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G |
Mbnl1 |
muscleblind-like splicing regulator 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of MBNL1 mRNA |
CTD |
PMID:37077353 |
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NCBI chr 2:144,639,819...144,814,395
Ensembl chr 2:144,670,285...144,814,368
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G |
Mc3r |
melanocortin 3 receptor |
decreases expression |
EXP |
Ketoconazole results in decreased expression of MC3R mRNA |
CTD |
PMID:37077353 |
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NCBI chr 3:161,016,347...161,017,444
Ensembl chr 3:161,016,347...161,017,444
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G |
Mcl1 |
MCL1 apoptosis regulator, BCL2 family member |
multiple interactions |
ISO |
[Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of MCL1 protein |
CTD |
PMID:31629065 |
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NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
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G |
Mcm7 |
minichromosome maintenance complex component 7 |
increases expression |
EXP |
Ketoconazole results in increased expression of MCM7 mRNA |
CTD |
PMID:37077353 |
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NCBI chr12:17,042,207...17,049,470
Ensembl chr12:17,042,212...17,050,063
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G |
Mdh1 |
malate dehydrogenase 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of MDH1 mRNA |
CTD |
PMID:37077353 |
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NCBI chr14:95,630,625...95,645,920
Ensembl chr14:95,630,306...95,645,925
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G |
Me1 |
malic enzyme 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of ME1 mRNA |
CTD |
PMID:37077353 |
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NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304
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G |
Met |
MET proto-oncogene, receptor tyrosine kinase |
increases expression |
ISO |
Ketoconazole results in increased expression of MET mRNA |
CTD |
PMID:32816093 |
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NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
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G |
Mfn1 |
mitofusin 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of MFN1 mRNA |
CTD |
PMID:36621641 |
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NCBI chr 2:115,313,380...115,359,651
Ensembl chr 2:115,313,401...115,359,640
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G |
Mgll |
monoglyceride lipase |
increases expression |
EXP |
Ketoconazole results in increased expression of MGLL mRNA |
CTD |
PMID:37077353 |
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NCBI chr 4:121,192,186...121,294,187
Ensembl chr 4:121,192,195...121,294,179
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G |
Mgp |
matrix Gla protein |
affects expression |
EXP |
Ketoconazole affects the expression of MGP mRNA |
CTD |
PMID:18289764 |
|
NCBI chr 4:169,766,290...169,769,612
Ensembl chr 4:169,766,279...169,769,667
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G |
Mgst1 |
microsomal glutathione S-transferase 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of MGST1 mRNA |
CTD |
PMID:37077353 |
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NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892
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G |
Mgst2 |
microsomal glutathione S-transferase 2 |
increases expression |
ISO |
Ketoconazole results in increased expression of MGST2 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 2:135,679,524...135,715,828
Ensembl chr 2:135,693,557...135,715,828
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G |
Micb |
MHC class I polypeptide-related sequence B |
increases expression |
ISO |
Ketoconazole results in increased expression of MICB mRNA |
CTD |
PMID:32060585 |
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NCBI chr 1:78,495,779...78,513,030
Ensembl chr 1:78,495,779...78,512,827
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G |
Micu1 |
mitochondrial calcium uptake 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of MICU1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr20:27,668,681...27,816,322
Ensembl chr20:27,668,747...27,814,964
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G |
Mill1 |
MHC I like leukocyte 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of MICA mRNA |
CTD |
PMID:32060585 |
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NCBI chr 1:78,372,798...78,398,932
Ensembl chr 1:78,372,802...78,398,930
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G |
Mki67 |
marker of proliferation Ki-67 |
increases expression |
ISO |
Ketoconazole results in increased expression of MKI67 mRNA |
CTD |
PMID:25808816 |
|
NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
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G |
Mkrn3 |
makorin, ring finger protein, 3 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of MKRN3 mRNA |
CTD |
PMID:37077353 |
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NCBI chr 1:115,926,774...115,929,288
Ensembl chr 1:115,926,776...115,929,283
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Mlx |
MAX dimerization protein MLX |
affects expression |
EXP |
Ketoconazole affects the expression of MLX mRNA |
CTD |
PMID:18355885 |
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NCBI chr10:86,019,216...86,024,326
Ensembl chr10:86,019,588...86,032,350
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Mlycd |
malonyl-CoA decarboxylase |
increases expression |
EXP |
Ketoconazole results in increased expression of MLYCD mRNA |
CTD |
PMID:37077353 |
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NCBI chr19:47,447,931...47,463,794
Ensembl chr19:47,447,970...47,463,793
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Mmab |
metabolism of cobalamin associated B |
increases expression |
ISO |
Ketoconazole results in increased expression of MMAB mRNA |
CTD |
PMID:36621641 |
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NCBI chr12:42,159,109...42,172,518
Ensembl chr12:42,159,089...42,172,490
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G |
Mmp14 |
matrix metallopeptidase 14 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of MMP14 mRNA |
CTD |
PMID:37077353 |
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NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864
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Mpzl1 |
myelin protein zero-like 1 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of MPZL1 mRNA |
CTD |
PMID:36621641 |
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NCBI chr13:77,852,467...77,889,305
Ensembl chr13:77,852,467...77,896,616
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Mrap2 |
melanocortin 2 receptor accessory protein 2 |
increases expression |
EXP |
Ketoconazole results in increased expression of MRAP2 mRNA |
CTD |
PMID:36653537 |
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NCBI chr 8:88,088,293...88,144,636
Ensembl chr 8:88,088,272...88,143,886
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Mras |
muscle RAS oncogene homolog |
increases expression |
ISO |
Ketoconazole results in increased expression of MRAS mRNA |
CTD |
PMID:36621641 |
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NCBI chr 8:99,944,036...100,006,771
Ensembl chr 8:99,944,036...99,996,408
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mrpl11 |
mitochondrial ribosomal protein L11 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of MRPL11 mRNA |
CTD |
PMID:36621641 |
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NCBI chr 1:202,264,419...202,267,288
Ensembl chr 1:202,264,471...202,267,756
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Mrpl18 |
mitochondrial ribosomal protein L18 |
increases expression |
ISO |
Ketoconazole results in increased expression of MRPL18 mRNA |
CTD |
PMID:36621641 |
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NCBI chr 1:47,837,169...47,841,987
Ensembl chr 1:47,836,561...47,841,987
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Mrpl32 |
mitochondrial ribosomal protein L32 |
increases expression |
ISO |
Ketoconazole results in increased expression of MRPL32 mRNA |
CTD |
PMID:36621641 |
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NCBI chr17:50,565,133...50,568,000
Ensembl chr17:50,565,055...50,568,010
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Mrps18b |
mitochondrial ribosomal protein S18B |
affects expression |
EXP |
Ketoconazole affects the expression of MRPS18B mRNA |
CTD |
PMID:18355885 |
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NCBI chr20:2,838,174...2,844,260
Ensembl chr20:2,838,030...2,844,260
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G |
Mrps30 |
mitochondrial ribosomal protein S30 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of MRPS30 mRNA |
CTD |
PMID:36621641 |
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NCBI chr 2:50,456,253...50,463,128
Ensembl chr 2:50,456,255...50,463,105
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G |
Mrps31 |
mitochondrial ribosomal protein S31 |
increases expression |
ISO |
Ketoconazole results in increased expression of MRPS31 mRNA |
CTD |
PMID:36621641 |
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NCBI chr16:69,601,349...69,621,609
Ensembl chr16:69,601,349...69,630,654
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Mrto4 |
MRT4 homolog, ribosome maturation factor |
increases expression |
EXP |
Ketoconazole results in increased expression of MRTO4 mRNA |
CTD |
PMID:37077353 |
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NCBI chr 5:151,601,780...151,608,533
Ensembl chr 5:151,601,780...151,608,287
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G |
Msmo1 |
methylsterol monooxygenase 1 |
affects expression multiple interactions increases expression |
EXP ISO |
Ketoconazole affects the expression of MSMO1 mRNA EIF2S1 protein mutant form promotes the reaction [Ketoconazole results in increased expression of MSMO1 mRNA] |
CTD |
PMID:16330322 PMID:18355885 |
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NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016
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Msn |
moesin |
increases expression |
EXP |
Ketoconazole results in increased expression of MSN mRNA |
CTD |
PMID:36653537 |
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NCBI chr X:60,996,043...61,064,011
Ensembl chr X:60,995,951...61,065,628
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G |
Mt1 |
metallothionein 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of MT1A mRNA |
CTD |
PMID:18289764 |
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NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049 Ensembl chr17:10,826,032...10,827,049
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Mtch2 |
mitochondrial carrier 2 |
increases expression |
ISO |
Ketoconazole results in increased expression of MTCH2 mRNA |
CTD |
PMID:36621641 |
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NCBI chr 3:76,830,549...76,850,189
Ensembl chr 3:76,830,413...76,850,189
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G |
Mthfd1l |
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like |
decreases expression |
ISO |
Ketoconazole results in decreased expression of MTHFD1L mRNA |
CTD |
PMID:36621641 |
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NCBI chr 1:40,443,926...40,632,911
Ensembl chr 1:40,444,008...40,632,905
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Mtmr2 |
myotubularin related protein 2 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of MTMR2 mRNA |
CTD |
PMID:36621641 |
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NCBI chr 8:10,617,993...10,670,724
Ensembl chr 8:10,617,993...10,668,172
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Mvd |
mevalonate diphosphate decarboxylase |
increases expression |
EXP |
Ketoconazole results in increased expression of MVD mRNA |
CTD |
PMID:37077353 |
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NCBI chr19:50,496,366...50,506,429
Ensembl chr19:50,496,367...50,507,971
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Myd88 |
MYD88, innate immune signal transduction adaptor |
increases expression |
EXP |
Ketoconazole results in increased expression of MYD88 mRNA |
CTD |
PMID:37077353 |
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NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
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Myh14 |
myosin heavy chain 14 |
increases expression |
EXP |
Ketoconazole results in increased expression of MYH14 mRNA |
CTD |
PMID:37077353 |
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NCBI chr 1:95,096,266...95,158,861
Ensembl chr 1:95,096,266...95,158,836
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G |
Myh7 |
myosin heavy chain 7 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of MYH7 mRNA |
CTD |
PMID:37077353 |
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NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217
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G |
Myt1 |
myelin transcription factor 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of MYT1 mRNA |
CTD |
PMID:31099283 |
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NCBI chr 3:168,890,466...168,950,341
Ensembl chr 3:168,886,089...168,950,341
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G |
Nasp |
nuclear autoantigenic sperm protein |
increases expression |
ISO |
Ketoconazole results in increased expression of NASP mRNA |
CTD |
PMID:36621641 |
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NCBI chr 5:130,057,363...130,083,003
Ensembl chr 5:130,057,363...130,082,928
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G |
Ncbp2as2 |
NCBP2 antisense 2 (head to head) |
increases expression |
ISO |
Ketoconazole results in increased expression of NCBP2AS2 mRNA |
CTD |
PMID:36621641 |
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NCBI chr11:68,829,950...68,830,715
Ensembl chr11:68,829,983...68,830,708
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G |
Ncf1 |
neutrophil cytosolic factor 1 |
decreases expression increases expression |
EXP |
Ketoconazole results in decreased expression of NCF1 mRNA Ketoconazole results in increased expression of NCF1 mRNA |
CTD |
PMID:25787151 PMID:37077353 |
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NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646
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Ncoa1 |
nuclear receptor coactivator 1 |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NR1H4 protein binds to NCOA1 protein]]; Ketoconazole inhibits the reaction [NR1I2 protein binds to NCOA1 protein]; Ketoconazole inhibits the reaction [Paclitaxel promotes the reaction [NR1I2 protein binds to NCOA1 protein]]; Ketoconazole inhibits the reaction [piperine promotes the reaction [NCOA1 protein binds to NR1I2 protein]]; Ketoconazole inhibits the reaction [Rifampin promotes the reaction [NR1I2 protein binds to NCOA1 protein]] |
CTD |
PMID:12072427 PMID:16819505 PMID:17438109 PMID:17998298 PMID:23525103 PMID:23707768 More...
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NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664
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G |
Ncor2 |
nuclear receptor co-repressor 2 |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [NCOR2 protein binds to NR1I2 protein]; Ketoconazole inhibits the reaction [NR1I2 protein binds to NCOR2 protein] |
CTD |
PMID:12072427 PMID:29356861 |
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NCBI chr12:31,466,418...31,628,319
Ensembl chr12:31,466,412...31,628,319
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G |
Ncr3lg1 |
natural killer cell cytotoxicity receptor 3 ligand 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of NCR3LG1 mRNA; Ketoconazole results in increased expression of NCR3LG1 protein |
CTD |
PMID:32060585 |
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NCBI chr 1:96,565,664...96,581,825
Ensembl chr 1:96,574,455...96,580,466
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G |
Ndrg1 |
N-myc downstream regulated 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of NDRG1 mRNA |
CTD |
PMID:37077353 |
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NCBI chr 7:98,684,487...98,725,869
Ensembl chr 7:98,684,487...98,725,880
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G |
Ndufa5 |
NADH:ubiquinone oxidoreductase subunit A5 |
increases expression |
EXP |
Ketoconazole results in increased expression of NDUFA5 mRNA |
CTD |
PMID:37077353 |
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NCBI chr 4:52,997,327...53,005,685
Ensembl chr 4:52,995,546...53,005,598
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G |
Neil2 |
nei-like DNA glycosylase 2 |
increases expression |
ISO |
Ketoconazole results in increased expression of NEIL2 mRNA |
CTD |
PMID:36621641 |
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NCBI chr15:37,444,676...37,454,863
Ensembl chr15:37,445,381...37,454,863
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Net1 |
neuroepithelial cell transforming 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of NET1 mRNA |
CTD |
PMID:36621641 |
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NCBI chr17:66,341,251...66,370,445
Ensembl chr17:66,340,728...66,370,441
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G |
Neto1 |
neuropilin and tolloid like 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of NETO1 mRNA |
CTD |
PMID:37077353 |
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NCBI chr18:79,635,633...79,753,913
Ensembl chr18:79,635,633...79,749,030
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions increases expression |
ISO EXP |
[Ketoconazole results in increased activity of AHR protein] which results in increased activity of and results in increased localization of NFE2L2 protein; NFE2L2 protein promotes the reaction [Ketoconazole inhibits the reaction [Benzo(a)pyrene results in increased abundance of Reactive Oxygen Species]]; NFE2L2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]]; NFE2L2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]] Ketoconazole results in increased expression of NFE2L2 mRNA; Ketoconazole results in increased expression of NFE2L2 protein [Ketoconazole co-treated with Carbon Tetrachloride] results in increased expression of NFE2L2 protein |
CTD |
PMID:21753779 PMID:31168027 PMID:37077353 |
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NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein] |
CTD |
PMID:23688403 |
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NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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Ngfr |
nerve growth factor receptor |
increases expression |
EXP |
Ketoconazole results in increased expression of NGFR mRNA |
CTD |
PMID:28263823 |
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NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518
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G |
Niban1 |
niban apoptosis regulator 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of NIBAN1 mRNA |
CTD |
PMID:36653537 |
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NCBI chr13:63,674,240...63,827,748
Ensembl chr13:63,674,171...63,827,729
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Niban2 |
niban apoptosis regulator 2 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of NIBAN2 mRNA |
CTD |
PMID:36621641 |
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NCBI chr 3:16,174,674...16,224,293
Ensembl chr 3:16,174,659...16,224,293
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Ninj1 |
ninjurin 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of NINJ1 mRNA |
CTD |
PMID:36621641 |
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NCBI chr17:15,452,804...15,461,684
Ensembl chr17:15,452,813...15,461,704
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Nlrp3 |
NLR family, pyrin domain containing 3 |
increases expression |
ISO |
Ketoconazole results in increased expression of NLRP3 mRNA |
CTD |
PMID:28138970 |
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NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
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Nos3 |
nitric oxide synthase 3 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of NOS3 mRNA |
CTD |
PMID:37077353 |
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NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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Npm2 |
nucleophosmin/nucleoplasmin 2 |
increases expression |
EXP |
Ketoconazole results in increased expression of NPM2 mRNA |
CTD |
PMID:36653537 |
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NCBI chr15:45,722,282...45,729,336
Ensembl chr15:45,722,400...45,729,726
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G |
Npr3 |
natriuretic peptide receptor 3 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of NPR3 mRNA |
CTD |
PMID:37077353 |
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NCBI chr 2:60,865,483...60,933,432
Ensembl chr 2:60,870,594...60,932,955
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Npw |
neuropeptide W |
decreases expression |
EXP |
Ketoconazole results in decreased expression of NPW mRNA |
CTD |
PMID:37077353 |
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NCBI chr10:13,680,275...13,681,618
Ensembl chr10:13,680,321...13,681,586
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Npy2r |
neuropeptide Y receptor Y2 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of NPY2R mRNA |
CTD |
PMID:37077353 |
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NCBI chr 2:167,901,999...167,912,165
Ensembl chr 2:167,903,879...167,905,024
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases expression multiple interactions |
ISO EXP |
Ketoconazole results in increased expression of NQO1 mRNA; Ketoconazole results in increased expression of NQO1 protein AHR promotes the reaction [Ketoconazole results in increased expression of NQO1 mRNA]; AHR promotes the reaction [Ketoconazole results in increased expression of NQO1 protein]; Dactinomycin inhibits the reaction [Ketoconazole results in increased expression of NQO1 mRNA] [Ketoconazole co-treated with Carbon Tetrachloride] results in increased expression of NQO1 mRNA |
CTD |
PMID:17923278 PMID:21753779 PMID:31168027 |
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NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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Nr0b2 |
nuclear receptor subfamily 0, group B, member 2 |
increases expression |
ISO |
Ketoconazole results in increased expression of NR0B2 mRNA |
CTD |
PMID:15342952 PMID:17175557 |
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NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
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Nr1d1 |
nuclear receptor subfamily 1, group D, member 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of NR1D1 mRNA |
CTD |
PMID:37077353 |
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NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705
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G |
Nr1h2 |
nuclear receptor subfamily 1, group H, member 2 |
multiple interactions increases expression |
ISO EXP |
Ketoconazole inhibits the reaction [T0901317 results in increased activity of NR1H2 protein] Ketoconazole results in increased expression of NR1H2 mRNA |
CTD |
PMID:16819505 PMID:37077353 |
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NCBI chr 1:95,041,967...95,047,358
Ensembl chr 1:95,041,967...95,047,377
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G |
Nr1h3 |
nuclear receptor subfamily 1, group H, member 3 |
multiple interactions |
EXP ISO |
Ketoconazole inhibits the reaction [Clofibrate results in increased expression of NR1H3 mRNA] Ketoconazole inhibits the reaction [T0901317 results in increased activity of NR1H3 protein] |
CTD |
PMID:14690017 PMID:16819505 |
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NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722
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Nr1h4 |
nuclear receptor subfamily 1, group H, member 4 |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NR1H4 protein binds to NCOA1 protein]]; Ketoconazole inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein] |
CTD |
PMID:16819505 |
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NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
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G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
multiple interactions increases activity decreases expression decreases response to substance |
ISO |
[Ketoconazole co-treated with Rifampin] results in increased activity of NR1I2 protein; Ketoconazole binds to and results in decreased activity of NR1I2 protein; Ketoconazole inhibits the reaction [Corticosterone promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]; Ketoconazole inhibits the reaction [NCOR2 protein binds to NR1I2 protein]; Ketoconazole inhibits the reaction [NR1I2 protein binds to NCOA1 protein]; Ketoconazole inhibits the reaction [NR1I2 protein binds to NCOR2 protein]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [piperine results in increased expression of ABCB1 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [piperine results in increased expression of ABCB1 protein]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [piperine results in increased expression of CYP3A4 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [piperine results in increased expression of CYP3A4 protein]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of ABCB1 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of ABCB1 protein]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 protein]]; Ketoconazole inhibits the reaction [NR1I2 protein results in decreased uptake of and results in decreased metabolism of Glucose]; Ketoconazole inhibits the reaction [Paclitaxel promotes the reaction [NR1I2 protein binds to NCOA1 protein]]; Ketoconazole inhibits the reaction [Paclitaxel results in increased activity of NR1I2 protein]; Ketoconazole inhibits the reaction [piperine promotes the reaction [NCOA1 protein binds to NR1I2 protein]]; Ketoconazole inhibits the reaction [Rifampin binds to and results in increased activity of NR1I2 protein]; Ketoconazole inhibits the reaction [Rifampin promotes the reaction [NR1I2 protein binds to NCOA1 protein]]; Ketoconazole inhibits the reaction [Rifampin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]; Ketoconazole inhibits the reaction [Rifampin results in increased activity of NR1I2 protein] Ketoconazole results in increased activity of NR1I2 protein Ketoconazole results in decreased expression of NR1I2 mRNA; Ketoconazole results in decreased expression of NR1I2 protein Ketoconazole inhibits the reaction [Pregnenolone Carbonitrile results in increased activity of NR1I2 protein] NR1I2 protein mutant form results in decreased susceptibility to Ketoconazole |
CTD |
PMID:12072427 PMID:16608920 PMID:16819505 PMID:17438109 PMID:17998298 PMID:20869355 PMID:21402137 PMID:23525103 PMID:23707768 PMID:25343516 PMID:25680588 PMID:26616219 PMID:29356861 PMID:36893891 More...
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NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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G |
Nr1i3 |
nuclear receptor subfamily 1, group I, member 3 |
multiple interactions decreases activity decreases expression |
ISO |
[Ketoconazole co-treated with PK 11195] results in decreased activity of NR1I3 protein alternative form; Ketoconazole binds to and results in decreased activity of NR1I3 protein alternative form; Ketoconazole inhibits the reaction [Dexamethasone results in increased expression of NR1I3 mRNA]; Ketoconazole inhibits the reaction [Phenobarbital results in increased activity of NR1I3 protein] Ketoconazole results in decreased activity of NR1I3 protein Ketoconazole results in decreased expression of NR1I3 mRNA Ketoconazole inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased activity of NR1I3 protein] |
CTD |
PMID:16608920 PMID:16819505 PMID:20869355 |
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NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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G |
Nr2f1 |
nuclear receptor subfamily 2, group F, member 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of NR2F1 mRNA |
CTD |
PMID:36621641 |
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NCBI chr 2:8,040,375...8,050,123
Ensembl chr 2:8,040,377...8,050,123
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G |
Nr3c1 |
nuclear receptor subfamily 3, group C, member 1 |
affects binding decreases activity multiple interactions |
ISO |
Ketoconazole binds to NR3C1 protein Ketoconazole results in decreased activity of NR3C1 protein Ketoconazole inhibits the reaction [Dexamethasone binds to and results in increased activity of NR3C1 protein] |
CTD |
PMID:15755314 PMID:16608920 PMID:25000292 |
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NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
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G |
Nr5a1 |
nuclear receptor subfamily 5, group A, member 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of NR5A1 mRNA |
CTD |
PMID:37077353 |
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NCBI chr 3:22,464,786...22,486,328
Ensembl chr 3:22,465,502...22,486,328
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G |
Nrep |
neuronal regeneration related protein |
affects expression |
EXP |
Ketoconazole affects the expression of NREP mRNA |
CTD |
PMID:18355885 |
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NCBI chr18:25,017,069...25,046,593
Ensembl chr18:25,017,083...25,046,591
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G |
Nrip3 |
nuclear receptor interacting protein 3 |
increases expression |
EXP |
Ketoconazole results in increased expression of NRIP3 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr 1:163,789,738...163,815,036
Ensembl chr 1:163,789,738...163,815,600
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G |
Nsdhl |
NAD(P) dependent steroid dehydrogenase-like |
increases expression |
EXP |
Ketoconazole results in increased expression of NSDHL mRNA |
CTD |
PMID:28263823 |
|
NCBI chr X:150,775,034...150,807,161
Ensembl chr X:150,775,080...150,807,142
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G |
Nsmf |
NMDA receptor synaptonuclear signaling and neuronal migration factor |
increases expression |
EXP |
Ketoconazole results in increased expression of NSMF mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 3:7,861,846...7,870,615
Ensembl chr 3:7,861,872...7,870,614
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G |
Ntng1 |
netrin G1 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of NTNG1 mRNA |
CTD |
PMID:31099283 |
|
NCBI chr 2:197,462,785...197,827,681
Ensembl chr 2:197,463,945...197,826,997
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G |
Nub1 |
negative regulator of ubiquitin-like proteins 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of NUB1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 4:10,442,917...10,473,689
Ensembl chr 4:10,442,917...10,473,694
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G |
Nudt4 |
nudix hydrolase 4 |
increases expression |
ISO |
Ketoconazole results in increased expression of NUDT4 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 7:30,188,100...30,204,615
Ensembl chr 7:30,188,100...30,204,615
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G |
Nup214 |
nucleoporin 214 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of NUP214 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr 3:15,255,111...15,340,568
Ensembl chr 3:15,255,119...15,340,568
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G |
Nup62 |
nucleoporin 62 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of NUP62 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr 1:95,298,995...95,314,902
Ensembl chr 1:95,295,526...95,315,174
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G |
Nupr1 |
nuclear protein 1, transcriptional regulator |
increases expression |
ISO |
Ketoconazole results in increased expression of NUPR1 mRNA |
CTD |
PMID:15342952 PMID:17175557 PMID:17567588 |
|
NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281
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G |
Oaf |
out at first homolog |
affects expression |
EXP |
Ketoconazole affects the expression of OAF mRNA |
CTD |
PMID:18355885 |
|
NCBI chr 8:43,594,362...43,612,334
Ensembl chr 8:43,594,363...43,612,334
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G |
Ociad1 |
OCIA domain containing 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of OCIAD1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr14:34,897,851...34,915,291
Ensembl chr14:34,897,847...34,915,286
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G |
Odc1 |
ornithine decarboxylase 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of ODC1 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
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G |
Osbpl8 |
oxysterol binding protein-like 8 |
increases expression |
ISO |
Ketoconazole results in increased expression of OSBPL8 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 7:46,596,944...46,749,888
Ensembl chr 7:46,596,983...46,749,888
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G |
Ovol1 |
ovo like transcriptional repressor 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of OVOL1 mRNA; Ketoconazole results in increased expression of OVOL1 protein |
CTD |
PMID:26873447 |
|
NCBI chr 1:202,855,261...202,868,858
Ensembl chr 1:202,855,265...202,866,831
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G |
Oxt |
oxytocin/neurophysin I prepropeptide |
increases expression |
EXP |
Ketoconazole results in increased expression of OXT mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 3:117,782,650...117,783,490
Ensembl chr 3:117,782,650...117,783,490
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G |
Pacs1 |
phosphofurin acidic cluster sorting protein 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of PACS1 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 1:202,437,503...202,569,473
Ensembl chr 1:202,437,505...202,569,473
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G |
Palld |
palladin, cytoskeletal associated protein |
decreases expression |
ISO |
Ketoconazole results in decreased expression of PALLD mRNA |
CTD |
PMID:31099283 |
|
NCBI chr16:28,228,006...28,621,349
Ensembl chr16:27,981,354...28,621,337
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G |
Papolg |
poly(A) polymerase gamma |
increases expression |
ISO |
Ketoconazole results in increased expression of PAPOLG mRNA |
CTD |
PMID:36621641 |
|
NCBI chr14:97,827,712...97,861,024
Ensembl chr14:97,827,712...97,861,024
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G |
Parg |
poly (ADP-ribose) glycohydrolase |
increases expression |
ISO |
Ketoconazole results in increased expression of PARG mRNA |
CTD |
PMID:36621641 |
|
NCBI chr16:7,436,429...7,544,276
Ensembl chr16:7,436,476...7,544,273
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of PARP1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Pc |
pyruvate carboxylase |
affects expression increases expression |
EXP |
Ketoconazole affects the expression of PC mRNA Ketoconazole results in increased expression of PC mRNA |
CTD |
PMID:18355885 PMID:37077353 |
|
NCBI chr 1:201,799,374...201,898,412
Ensembl chr 1:201,804,267...201,898,380
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G |
Pcbd1 |
pterin-4 alpha-carbinolamine dehydratase 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of PCBD1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr20:29,037,545...29,044,322
Ensembl chr20:28,953,864...29,044,292 Ensembl chr20:28,953,864...29,044,292
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G |
Pcdh9 |
protocadherin 9 |
increases expression |
ISO |
Ketoconazole results in increased expression of PCDH9 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr15:69,340,108...70,237,531
Ensembl chr15:69,340,645...70,237,538
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|
G |
Pcna |
proliferating cell nuclear antigen |
increases expression |
EXP |
Ketoconazole results in increased expression of PCNA mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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G |
Pcnp |
PEST proteolytic signal containing nuclear protein |
decreases expression |
ISO |
Ketoconazole results in decreased expression of PCNP mRNA |
CTD |
PMID:36621641 |
|
NCBI chr11:44,592,766...44,607,372
Ensembl chr11:44,592,742...44,607,348
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|
G |
Pcsk5 |
proprotein convertase subtilisin/kexin type 5 |
increases expression |
ISO |
Ketoconazole results in increased expression of PCSK5 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 1:214,837,847...215,267,626
Ensembl chr 1:214,837,927...215,267,600
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|
G |
Pcsk9 |
proprotein convertase subtilisin/kexin type 9 |
increases expression |
EXP |
Ketoconazole results in increased expression of PCSK9 mRNA |
CTD |
PMID:28263823 |
|
NCBI chr 5:121,211,278...121,233,688
Ensembl chr 5:121,211,278...121,233,688
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G |
Pctp |
phosphatidylcholine transfer protein |
increases expression |
EXP |
Ketoconazole results in increased expression of PCTP mRNA |
CTD |
PMID:37077353 |
|
NCBI chr10:74,808,887...74,856,260
Ensembl chr10:74,808,887...74,849,867
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G |
Pde3b |
phosphodiesterase 3B |
decreases expression |
EXP |
Ketoconazole results in decreased expression of PDE3B mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 1:168,606,762...168,770,078
Ensembl chr 1:168,607,022...168,769,334
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G |
Pdhb |
pyruvate dehydrogenase E1 subunit beta |
increases expression |
EXP |
Ketoconazole results in increased expression of PDHB mRNA |
CTD |
PMID:37077353 |
|
NCBI chr15:16,752,561...16,758,503
Ensembl chr15:16,750,980...16,758,500
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G |
Pdlim5 |
PDZ and LIM domain 5 |
increases expression |
ISO |
Ketoconazole results in increased expression of PDLIM5 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 2:230,952,251...231,120,329
Ensembl chr 2:230,952,248...231,120,275
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|
G |
Pdyn |
prodynorphin |
decreases expression |
EXP |
Ketoconazole results in decreased expression of PDYN mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334
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|
G |
Pea15 |
proliferation and apoptosis adaptor protein 15 |
increases expression |
EXP |
Ketoconazole results in increased expression of PEA15 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr13:84,657,815...84,667,437
Ensembl chr13:84,654,870...84,667,499
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G |
Pecr |
peroxisomal trans-2-enoyl-CoA reductase |
affects expression |
EXP |
Ketoconazole affects the expression of PECR mRNA |
CTD |
PMID:18355885 |
|
NCBI chr 9:73,897,877...73,926,511
Ensembl chr 9:73,897,880...73,926,511
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G |
Pepd |
peptidase D |
increases expression |
EXP |
Ketoconazole results in increased expression of PEPD mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 1:87,536,650...87,681,233
Ensembl chr 1:87,536,609...87,681,231
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G |
Per3 |
period circadian regulator 3 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of PER3 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 5:161,460,228...161,495,404
Ensembl chr 5:161,459,533...161,495,607
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G |
Perp |
p53 apoptosis effector related to PMP22 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of PERP mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 1:13,542,067...13,554,514
Ensembl chr 1:13,542,067...13,554,511
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G |
Pf4 |
platelet factor 4 |
increases expression |
EXP |
Ketoconazole results in increased expression of PF4 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr14:17,298,304...17,299,220
Ensembl chr14:17,298,308...17,299,365
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G |
Pgf |
placental growth factor |
increases expression |
EXP |
Ketoconazole results in increased expression of PGF mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 6:104,816,102...104,826,685
Ensembl chr 6:104,816,104...104,826,685
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|
G |
Pgr |
progesterone receptor |
increases expression |
ISO |
Ketoconazole results in increased expression of PGR mRNA |
CTD |
PMID:35307500 |
|
NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
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|
G |
Phf6 |
PHD finger protein 6 |
increases expression |
ISO |
Ketoconazole results in increased expression of PHF6 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr X:132,656,658...132,699,720
Ensembl chr X:132,656,672...132,699,127
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G |
Phf7 |
PHD finger protein 7 |
increases expression |
ISO |
Ketoconazole results in increased expression of PHF7 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr16:6,433,535...6,446,314
Ensembl chr16:6,433,537...6,446,911
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G |
Pim1 |
Pim-1 proto-oncogene, serine/threonine kinase |
decreases expression |
ISO |
Ketoconazole results in decreased expression of PIM1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr20:7,554,921...7,559,174
Ensembl chr20:7,554,921...7,559,174
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G |
Pip5k1a |
phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha |
increases expression |
ISO |
Ketoconazole results in increased expression of PIP5K1A mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 2:182,628,299...182,671,584
Ensembl chr 2:182,628,300...182,671,598
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G |
Pkp2 |
plakophilin 2 |
increases expression |
ISO |
Ketoconazole results in increased expression of PKP2 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr11:84,661,783...84,727,730
Ensembl chr11:84,661,783...84,727,730
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G |
Pla2g3 |
phospholipase A2, group III |
increases expression |
EXP |
Ketoconazole results in increased expression of PLA2G3 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr14:78,367,625...78,373,913
Ensembl chr14:78,368,105...78,373,913
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G |
Pla2g7 |
phospholipase A2 group VII |
decreases expression |
EXP |
Ketoconazole results in decreased expression of PLA2G7 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr 9:17,362,214...17,404,476
Ensembl chr 9:17,362,225...17,404,476
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G |
Plaat3 |
phospholipase A and acyltransferase 3 |
increases expression |
ISO |
Ketoconazole results in increased expression of PLAAT3 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 1:204,782,608...204,816,397
Ensembl chr 1:204,782,729...204,817,667
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G |
Plag1 |
PLAG1 zinc finger |
decreases expression |
EXP |
Ketoconazole results in decreased expression of PLAG1 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr 5:16,902,057...16,956,727
Ensembl chr 5:16,905,394...16,913,647
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G |
Plcxd2 |
phosphatidylinositol-specific phospholipase C, X domain containing 2 |
increases expression |
EXP |
Ketoconazole results in increased expression of PLCXD2 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr11:54,800,977...54,853,348
Ensembl chr11:54,789,477...54,853,344
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G |
Plekha4 |
pleckstrin homology domain containing A4 |
increases expression |
EXP |
Ketoconazole results in increased expression of PLEKHA4 mRNA |
CTD |
PMID:28263823 |
|
NCBI chr 1:96,005,824...96,028,826
Ensembl chr 1:96,006,000...96,028,826
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G |
Plin4 |
perilipin 4 |
increases expression |
EXP |
Ketoconazole results in increased expression of PLIN4 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 9:929,168...938,062
Ensembl chr 9:929,176...938,056
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G |
Plscr4 |
phospholipid scramblase 4 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of PLSCR4 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 8:92,987,290...93,026,056
Ensembl chr 8:92,987,381...93,026,049
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G |
Pmm1 |
phosphomannomutase 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of PMM1 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 7:113,466,632...113,477,004
Ensembl chr 7:113,466,632...113,477,022
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|
G |
Pmvk |
phosphomevalonate kinase |
increases expression |
EXP |
Ketoconazole results in increased expression of PMVK mRNA |
CTD |
PMID:28263823 PMID:37077353 |
|
NCBI chr 2:174,876,586...174,886,365
Ensembl chr 2:174,876,657...174,886,364
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G |
Pnpla6 |
patatin-like phospholipase domain containing 6 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of PNPLA6 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr12:1,574,387...1,603,735
Ensembl chr12:1,560,363...1,603,734
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G |
Polr1d |
RNA polymerase I and III subunit D |
decreases expression |
ISO |
Ketoconazole results in decreased expression of POLR1D mRNA |
CTD |
PMID:36621641 |
|
NCBI chr12:7,970,592...8,004,157
Ensembl chr12:7,970,595...8,005,624
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G |
Pomc |
proopiomelanocortin |
decreases expression |
ISO |
Ketoconazole results in decreased expression of POMC protein modified form |
CTD |
PMID:25808816 |
|
NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
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G |
Pon2 |
paraoxonase 2 |
increases expression |
ISO |
Ketoconazole results in increased expression of PON2 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 4:33,389,702...33,425,186
Ensembl chr 4:33,389,714...33,425,248
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G |
Por |
cytochrome p450 oxidoreductase |
affects expression multiple interactions increases expression decreases expression |
EXP ISO |
Ketoconazole affects the expression of POR mRNA Ketoconazole affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] Ketoconazole results in increased expression of POR protein Ketoconazole results in decreased expression of POR mRNA |
CTD |
PMID:17966066 PMID:18355885 PMID:24120545 PMID:36653537 |
|
NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
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|
G |
Pou2f1 |
POU class 2 homeobox 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of POU2F1 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr13:78,120,617...78,263,306
Ensembl chr13:78,130,685...78,263,363
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G |
Pou5f1 |
POU class 5 homeobox 1 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of POU5F1 mRNA |
CTD |
PMID:16574651 |
|
NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
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G |
Ppara |
peroxisome proliferator activated receptor alpha |
multiple interactions |
EXP |
Ketoconazole inhibits the reaction [Clofibrate results in increased expression of PPARA mRNA] |
CTD |
PMID:14690017 |
|
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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G |
Ppard |
peroxisome proliferator-activated receptor delta |
increases expression |
EXP |
Ketoconazole results in increased expression of PPARD mRNA |
CTD |
PMID:37077353 |
|
NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968
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G |
Ppargc1a |
PPARG coactivator 1 alpha |
decreases expression |
EXP |
Ketoconazole results in decreased expression of PPARGC1A mRNA |
CTD |
PMID:37077353 |
|
NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
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G |
Ppargc1b |
PPARG coactivator 1 beta |
decreases expression |
EXP |
Ketoconazole results in decreased expression of PPARGC1B mRNA |
CTD |
PMID:37077353 |
|
NCBI chr18:54,758,891...54,861,103
Ensembl chr18:54,758,902...54,861,194
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G |
Ppp2cb |
protein phosphatase 2 catalytic subunit beta |
decreases expression |
EXP |
Ketoconazole results in decreased expression of PPP2CB mRNA |
CTD |
PMID:25787151 |
|
NCBI chr16:58,558,119...58,579,325
Ensembl chr16:58,558,122...58,579,576
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G |
Ppp2r2b |
protein phosphatase 2, regulatory subunit B, beta |
increases expression |
EXP |
Ketoconazole results in increased expression of PPP2R2B mRNA |
CTD |
PMID:37077353 |
|
NCBI chr18:34,653,716...35,080,889
Ensembl chr18:34,653,721...35,081,025
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|
G |
Ppp2r3a |
protein phosphatase 2, regulatory subunit B'', alpha |
decreases expression |
ISO |
Ketoconazole results in decreased expression of PPP2R3A mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 8:101,703,512...101,841,530
Ensembl chr 8:101,704,778...101,841,502
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|
G |
Pqbp1 |
polyglutamine binding protein 1 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of PQBP1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr X:14,603,516...14,608,091
Ensembl chr X:14,603,539...14,608,087
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|
G |
Prc1 |
protein regulator of cytokinesis 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of PRC1 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 1:134,250,086...134,271,765
Ensembl chr 1:134,250,081...134,271,765
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G |
Prcc |
proline rich mitotic checkpoint control factor |
increases expression |
ISO |
Ketoconazole results in increased expression of PRCC mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 2:173,326,261...173,351,799
Ensembl chr 2:173,326,259...173,351,825
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|
G |
Prdm1 |
PR/SET domain 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of PRDM1 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr20:47,959,858...47,981,488
Ensembl chr20:47,959,858...47,981,488
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|
G |
Prdx3 |
peroxiredoxin 3 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of PRDX3 mRNA |
CTD |
PMID:25787151 |
|
NCBI chr 1:260,001,642...260,014,064
Ensembl chr 1:260,001,637...260,014,111
|
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G |
Prkar1b |
protein kinase cAMP-dependent type I regulatory subunit beta |
decreases expression |
ISO |
Ketoconazole results in decreased expression of PRKAR1B mRNA |
CTD |
PMID:36621641 |
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NCBI chr12:15,492,233...15,624,942
Ensembl chr12:15,511,801...15,624,942
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G |
Prkg2 |
protein kinase cGMP-dependent 2 |
increases expression |
EXP |
Ketoconazole results in increased expression of PRKG2 mRNA |
CTD |
PMID:37077353 |
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NCBI chr14:10,559,882...10,668,479
Ensembl chr14:10,559,882...10,666,888
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G |
Prkn |
parkin RBR E3 ubiquitin protein ligase |
multiple interactions increases expression increases response to substance |
EXP |
1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Ketoconazole results in increased expression of PRKN mRNA]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Ketoconazole results in increased expression of PRKN protein]; tempol inhibits the reaction [Ketoconazole results in increased expression of PRKN mRNA]; tempol inhibits the reaction [Ketoconazole results in increased expression of PRKN protein] Ketoconazole results in increased expression of PRKN mRNA; Ketoconazole results in increased expression of PRKN protein PRKN protein results in increased susceptibility to Ketoconazole |
CTD |
PMID:25787151 |
|
NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555
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G |
Prl |
prolactin |
decreases expression |
EXP |
Ketoconazole results in decreased expression of PRL mRNA |
CTD |
PMID:25808816 |
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NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
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G |
Psmb8 |
proteasome 20S subunit beta 8 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of PSMB8 mRNA |
CTD |
PMID:36621641 |
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NCBI chr20:4,652,159...4,655,122
Ensembl chr20:4,652,159...4,655,283
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G |
Psmc2 |
proteasome 26S subunit, ATPase 2 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of PSMC2 mRNA |
CTD |
PMID:36621641 |
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NCBI chr 4:13,255,850...13,270,160
Ensembl chr 4:13,255,856...13,270,185
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G |
Psmd13 |
proteasome 26S subunit, non-ATPase 13 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of PSMD13 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 1:195,964,617...195,976,895
Ensembl chr 1:195,964,138...195,976,905
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G |
Psmd5 |
proteasome 26S subunit, non-ATPase 5 |
increases expression |
ISO |
Ketoconazole results in increased expression of PSMD5 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 3:18,133,715...18,151,000
Ensembl chr 3:18,133,717...18,151,029
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G |
Psmg3 |
proteasome assembly chaperone 3 |
increases expression |
ISO |
Ketoconazole results in increased expression of PSMG3 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr12:14,809,440...14,812,357
Ensembl chr12:14,809,450...14,812,342
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G |
Psmg4 |
proteasome assembly chaperone 4 |
increases expression |
ISO |
Ketoconazole results in increased expression of PSMG4 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr17:30,710,682...30,718,035
Ensembl chr17:30,710,682...30,718,082
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G |
Pten |
phosphatase and tensin homolog |
decreases expression |
EXP |
Ketoconazole results in decreased expression of PTEN mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838
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G |
Ptgds |
prostaglandin D2 synthase |
decreases expression increases expression |
ISO EXP |
Ketoconazole results in decreased expression of PTGDS mRNA Ketoconazole results in increased expression of PTGDS mRNA |
CTD |
PMID:31099283 PMID:36653537 |
|
NCBI chr 3:8,281,899...8,284,833
Ensembl chr 3:8,281,899...8,284,833
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G |
Ptger2 |
prostaglandin E receptor 2 |
multiple interactions increases response to substance |
ISO |
PTGER2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; PTGER2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; PTGER2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]] PTGER2 protein results in increased susceptibility to Ketoconazole |
CTD |
PMID:16784723 |
|
NCBI chr15:18,215,013...18,228,714
Ensembl chr15:18,217,285...18,228,714
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G |
Ptger3 |
prostaglandin E receptor 3 |
multiple interactions increases response to substance increases expression |
ISO EXP |
PTGER3 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; PTGER3 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; PTGER3 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]] PTGER3 protein results in increased susceptibility to Ketoconazole Ketoconazole results in increased expression of PTGER3 mRNA |
CTD |
PMID:16784723 PMID:37077353 |
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NCBI chr 2:246,606,131...246,750,970
Ensembl chr 2:246,606,183...246,684,434
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions increases expression |
ISO |
Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [Dinoprostone results in increased expression of PTGS2 mRNA]]; Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [Dinoprostone results in increased expression of PTGS2 protein]]; Ketoconazole inhibits the reaction [Dinoprostone promotes the reaction [ATF1 protein modified form binds to PTGS2 promoter]]; Ketoconazole inhibits the reaction [Dinoprostone promotes the reaction [CREB1 protein modified form binds to PTGS2 promoter]]; Ketoconazole inhibits the reaction [Dinoprostone results in increased expression of PTGS2 mRNA]; Ketoconazole inhibits the reaction [Dinoprostone results in increased expression of PTGS2 protein] Ketoconazole results in increased expression of PTGS2 mRNA |
CTD |
PMID:12164941 PMID:32816093 |
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NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Pth |
parathyroid hormone |
multiple interactions |
EXP |
Ketoconazole inhibits the reaction [25-hydroxyvitamin D results in decreased expression of PTH mRNA] |
CTD |
PMID:18304585 |
|
NCBI chr 1:167,508,121...167,511,530
Ensembl chr 1:167,508,598...167,511,530
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G |
Ptpn14 |
protein tyrosine phosphatase, non-receptor type 14 |
increases expression |
ISO |
Ketoconazole results in increased expression of PTPN14 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr13:101,268,258...101,420,508
Ensembl chr13:101,268,416...101,414,088
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G |
Ptprf |
protein tyrosine phosphatase, receptor type, F |
decreases expression |
EXP |
Ketoconazole results in decreased expression of PTPRF mRNA |
CTD |
PMID:37077353 |
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NCBI chr 5:131,741,959...131,824,000
Ensembl chr 5:131,742,754...131,810,023
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G |
Ptx3 |
pentraxin 3 |
affects expression |
EXP |
Ketoconazole affects the expression of PTX3 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr 2:150,487,513...150,493,323
Ensembl chr 2:150,487,513...150,493,323
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G |
Pygl |
glycogen phosphorylase L |
increases expression |
EXP |
Ketoconazole results in increased expression of PYGL mRNA |
CTD |
PMID:37077353 |
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NCBI chr 6:88,697,598...88,740,260
Ensembl chr 6:88,697,593...88,740,310
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G |
Qsox1 |
quiescin sulfhydryl oxidase 1 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of QSOX1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr13:67,949,780...67,987,434
Ensembl chr13:67,949,780...67,987,459
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G |
Rab3b |
RAB3B, member RAS oncogene family |
increases expression |
ISO |
Ketoconazole results in increased expression of RAB3B mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 5:123,629,562...123,697,410
Ensembl chr 5:123,644,423...123,697,401
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G |
Rab9a |
RAB9A, member RAS oncogene family |
increases expression |
ISO |
Ketoconazole results in increased expression of RAB9A mRNA |
CTD |
PMID:36621641 |
|
NCBI chr X:27,955,552...28,009,870
Ensembl chr X:27,952,204...28,001,622
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G |
Ralgdsl1 |
ral guanine nucleotide dissociation stimulator like 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of RGL1 mRNA |
CTD |
PMID:37077353 |
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NCBI chr13:64,634,489...64,904,170
Ensembl chr13:64,635,246...64,904,191
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G |
Rapgef1 |
Rap guanine nucleotide exchange factor 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of RAPGEF1 mRNA |
CTD |
PMID:37077353 |
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NCBI chr 3:12,898,349...13,016,234
Ensembl chr 3:12,898,266...13,013,984
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G |
Rapgef4 |
Rap guanine nucleotide exchange factor 4 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of RAPGEF4 mRNA |
CTD |
PMID:31099283 |
|
NCBI chr 3:56,809,388...57,101,332
Ensembl chr 3:56,809,270...57,102,316
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G |
Rarb |
retinoic acid receptor, beta |
increases expression decreases expression |
EXP |
Ketoconazole results in increased expression of RARB mRNA Ketoconazole results in decreased expression of RARB mRNA |
CTD |
PMID:28263823 PMID:37077353 |
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NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288
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G |
Rarres2 |
retinoic acid receptor responder 2 |
increases expression |
EXP |
Ketoconazole results in increased expression of RARRES2 mRNA |
CTD |
PMID:37077353 |
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NCBI chr 4:77,522,549...77,525,733
Ensembl chr 4:77,522,535...77,525,556
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G |
Rbl2 |
RB transcriptional corepressor like 2 |
affects expression |
EXP |
Ketoconazole affects the expression of RBL2 mRNA |
CTD |
PMID:18355885 |
|
NCBI chr19:15,876,852...15,923,632
Ensembl chr19:15,876,853...15,923,572
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G |
Rbm26 |
RNA binding motif protein 26 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of RBM26 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr15:81,884,783...81,964,245
Ensembl chr15:81,887,219...81,964,118
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
EXP |
Ketoconazole inhibits the reaction [Carbon Tetrachloride results in increased expression of RELA protein] |
CTD |
PMID:31168027 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Ren |
renin |
decreases expression |
ISO |
Ketoconazole results in decreased expression of REN protein |
CTD |
PMID:2632720 |
|
NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
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G |
Rft1 |
RFT1 homolog |
decreases expression |
ISO |
Ketoconazole results in decreased expression of RFT1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr16:5,827,063...5,861,120
Ensembl chr16:5,827,088...5,861,120
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G |
Rgs16 |
regulator of G-protein signaling 16 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of RGS16 mRNA |
CTD |
PMID:31099283 |
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NCBI chr13:65,887,668...65,892,862
Ensembl chr13:65,887,530...65,892,857
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G |
Rhno1 |
RAD9-HUS1-RAD1 interacting nuclear orphan 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of RHNO1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 4:161,634,047...161,639,437
Ensembl chr 4:161,634,048...161,639,371
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G |
Rhob |
ras homolog family member B |
increases expression |
EXP |
Ketoconazole results in increased expression of RHOB mRNA |
CTD |
PMID:37077353 |
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NCBI chr 6:31,363,752...31,365,926
Ensembl chr 6:31,363,548...31,366,108
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G |
Rilpl1 |
Rab interacting lysosomal protein-like 1 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of RILPL1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr12:32,071,870...32,109,687
Ensembl chr12:32,071,693...32,109,938
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G |
Rnase4 |
ribonuclease A family member 4 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of RNASE4 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr15:24,312,765...24,330,112
Ensembl chr15:24,312,464...24,330,117
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G |
Rnf115 |
ring finger protein 115 |
increases expression |
ISO |
Ketoconazole results in increased expression of RNF115 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 2:184,262,087...184,329,839
Ensembl chr 2:184,262,371...184,329,823
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G |
Rnf41 |
ring finger protein 41 |
increases expression |
EXP |
Ketoconazole results in increased expression of RNF41 mRNA |
CTD |
PMID:25787151 |
|
NCBI chr 7:838,160...876,869
Ensembl chr 7:838,203...865,511
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G |
Rnf8 |
ring finger protein 8 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of RNF8 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr20:7,682,258...7,710,448
Ensembl chr20:7,682,322...7,708,491
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G |
Rpp25 |
ribonuclease P and MRP subunit p25 |
increases expression |
ISO |
Ketoconazole results in increased expression of RPP25 mRNA |
CTD |
PMID:31099283 |
|
NCBI chr 8:57,907,352...57,908,732
Ensembl chr 8:57,907,352...57,908,732
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G |
Rps25 |
ribosomal protein s25 |
increases expression |
ISO |
Ketoconazole results in increased expression of RPS25 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 8:44,733,623...44,735,999
Ensembl chr 8:44,733,029...44,737,271
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G |
Rpsa |
ribosomal protein SA |
increases expression |
EXP |
Ketoconazole results in increased expression of RPSA mRNA |
CTD |
PMID:37077353 |
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NCBI chr 8:119,851,225...119,855,103
Ensembl chr 8:119,851,225...119,855,247
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G |
Rrm2 |
ribonucleotide reductase regulatory subunit M2 |
increases expression |
ISO |
Ketoconazole results in increased expression of RRM2 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773
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G |
Rsf1 |
remodeling and spacing factor 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of RSF1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 1:151,892,055...152,015,089
Ensembl chr 1:151,892,434...152,009,051
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G |
RT1-Bb |
RT1 class II, locus Bb |
decreases expression |
EXP |
Ketoconazole results in decreased expression of RT1-BB mRNA |
CTD |
PMID:36653537 |
|
NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597
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G |
RT1-S3 |
RT1 class Ib, locus S3 |
affects expression |
EXP |
Ketoconazole affects the expression of RT1-S3 mRNA |
CTD |
PMID:18355885 |
|
NCBI chr20:2,670,654...2,675,411
Ensembl chr20:2,670,709...2,675,411
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G |
Runx2 |
RUNX family transcription factor 2 |
multiple interactions decreases expression |
ISO EXP |
Ketoconazole inhibits the reaction [Calcifediol results in increased expression of RUNX2 mRNA] Ketoconazole results in decreased expression of RUNX2 mRNA |
CTD |
PMID:21542014 PMID:37077353 |
|
NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
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G |
Rxra |
retinoid X receptor alpha |
decreases expression |
EXP |
Ketoconazole results in decreased expression of RXRA mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
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G |
Rxrg |
retinoid X receptor gamma |
decreases expression |
EXP |
Ketoconazole results in decreased expression of RXRG mRNA |
CTD |
PMID:37077353 |
|
NCBI chr13:79,743,430...79,785,173
Ensembl chr13:79,743,563...79,785,167
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G |
Samd8 |
sterile alpha motif domain containing 8 |
increases expression |
ISO |
Ketoconazole results in increased expression of SAMD8 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr15:2,512,104...2,562,368
Ensembl chr15:2,512,105...2,515,379 Ensembl chr15:2,512,105...2,515,379
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G |
Sbno1 |
strawberry notch homolog 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of SBNO1 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr12:32,175,176...32,234,200
Ensembl chr12:32,185,485...32,230,158
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G |
Sc5d |
sterol-C5-desaturase |
increases expression |
EXP |
Ketoconazole results in increased expression of SC5D mRNA |
CTD |
PMID:28263823 |
|
NCBI chr 8:42,629,649...42,641,257
Ensembl chr 8:42,632,672...42,641,273
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G |
Scarb1 |
scavenger receptor class B, member 1 |
decreases expression increases expression |
EXP ISO |
Ketoconazole results in decreased expression of SCARB1 mRNA Ketoconazole results in increased expression of SCARB1 mRNA |
CTD |
PMID:36621641 PMID:37077353 |
|
NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647
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G |
Scarb2 |
scavenger receptor class B, member 2 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of SCARB2 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr14:15,558,271...15,609,813
Ensembl chr14:15,558,236...15,609,813
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G |
Scd |
stearoyl-CoA desaturase |
increases expression |
EXP ISO |
Ketoconazole results in increased expression of SCD mRNA; Ketoconazole results in increased expression of SCD1 mRNA Ketoconazole results in increased expression of SCD mRNA; Ketoconazole results in increased expression of SCD protein |
CTD |
PMID:28263823 PMID:36621641 PMID:37077353 |
|
NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
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G |
Scgb1c1 |
secretoglobin, family 1C, member 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of SCGB1C1 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr 1:195,922,660...195,925,022
Ensembl chr 1:195,923,803...195,925,022
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G |
Scp2 |
sterol carrier protein 2 |
increases expression |
EXP |
Ketoconazole results in increased expression of SCP2 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 5:122,806,949...122,881,259
Ensembl chr 5:122,776,549...122,881,287
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G |
Sdc1 |
syndecan 1 |
increases expression |
EXP ISO |
Ketoconazole results in increased expression of SDC1 mRNA |
CTD |
PMID:36621641 PMID:37077353 |
|
NCBI chr 6:31,562,799...31,585,267
Ensembl chr 6:31,562,739...31,585,264
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G |
Sdc4 |
syndecan 4 |
increases expression |
EXP |
Ketoconazole results in increased expression of SDC4 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr 3:153,154,888...153,173,576
Ensembl chr 3:153,154,896...153,173,580
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G |
Secisbp2 |
SECIS binding protein 2 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of SECISBP2 mRNA |
CTD |
| |