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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pyrrolopyrazine
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Accession:CHEBI:48337 term browser browse the term
Synonyms:related_synonym: pyrrolopyrazines


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maculosin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO maculosin inhibits the reaction [Diethylnitrosamine results in decreased expression of BAX protein] CTD PMID:34726822 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO maculosin inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2 protein] CTD PMID:34726822 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO maculosin inhibits the reaction [Diethylnitrosamine results in decreased expression of CASP3 mRNA]; maculosin inhibits the reaction [Diethylnitrosamine results in decreased expression of CASP3 protein] CTD PMID:34726822 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase multiple interactions ISO maculosin inhibits the reaction [Diethylnitrosamine results in decreased activity of CAT protein] CTD PMID:34726822 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO maculosin inhibits the reaction [Diethylnitrosamine results in decreased activity of GSR protein] CTD PMID:34726822 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions ISO maculosin inhibits the reaction [Diethylnitrosamine results in increased expression of PIK3R1 protein modified form] CTD PMID:34726822 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Pten phosphatase and tensin homolog multiple interactions ISO maculosin inhibits the reaction [Diethylnitrosamine results in decreased expression of PTEN protein] CTD PMID:34726822 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO maculosin inhibits the reaction [Diethylnitrosamine results in decreased expression of TRP53 mRNA]; maculosin inhibits the reaction [Diethylnitrosamine results in decreased expression of TRP53 protein] CTD PMID:34726822 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
zopiclone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases metabolic processing ISO CYP2C8 protein results in increased metabolism of zopiclone CTD PMID:12464242
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    chemical entity 19878
      atom 19878
        nonmetal atom 19800
          nitrogen atom 18979
            nitrogen molecular entity 18979
              organonitrogen compound 18833
                organonitrogen heterocyclic compound 18153
                  pyrrolopyrazine 9
                    (6S,8aS)-2-(benzylsulfonyl)-N-\{[1-(N'-hydroxycarbamimidoyl)piperidin-4-yl]methyl\}-4-oxooctahydropyrrolo[1,2-a]pyrazine-6-carboxamide 0
                    (8aS)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione 0
                    (S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one 0
                    (S)-3-\{[2-(1,1-dimethylallyl)-indol-3-yl]methyl\}-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one 0
                    1,2,3,4-tetrahydro-2-methyl-3-methylene-1,4-dioxopyrazino[1,2-a]indole 0
                    1,3-Dimethylpyrrolo[1,2-a]pyrazine 0
                    1,4-Dimethylpyrrolo[1,2-a]pyrazine 0
                    1-Methylpyrrolo[1,2-a]pyrazine 0
                    1-hydroxy-3-(indol-3-ylmethyl)-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazin-5-ylium 0
                    1-hydroxy-3-\{[2-(1,1-dimethylallyl)-indol-3-yl]methyl\}-4H,6H,7H,8H-pyrrolo[1,2-a]pyrazin-2-ium 0
                    1-hydroxy-3-\{[2-(1,1-dimethylallyl)-indol-3-yl]methyl\}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazin-5-ylium 0
                    18-oxotryprostatin A 0
                    2-\{3-[(3S,8aS)-1,4-dioxooctahydropyrrolo[1,2-a]pyrazin-3-yl]propyl\}guanidine 0
                    3,4-Dimethylpyrrolo[1,2-a]pyrazine 0
                    3-methylpyrrolo[1,2-a]pyrazine 0
                    4-(7-butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl)phenol 0
                    4-Methylpyrrolo[1,2-a]pyrazine 0
                    6-hydroxydeoxybrevianamide E 0
                    6-hydroxytryprostatin B 0
                    7-Azaindolizine 0
                    Brevianamide K 0
                    Brevianamide S 0
                    Brevianamide T 0
                    Le-pyrrolopyrazine A 0
                    Le-pyrrolopyrazine B 0
                    Le-pyrrolopyrazine C 0
                    Nannozinone A 0
                    Nannozinone B 0
                    Pyrocoll 0
                    Sorazinone A 0
                    brevianamide F + 0
                    butyl (2S,3S)-3-(trans-4-aminocyclohexyl)-3-(\{[2-(benzylsulfonyl)-4-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-6-yl]carbonyl\}amino)-2-hydroxypropanoate 0
                    cordysinin A 0
                    cyclo(L-His-L-Pro) 0
                    cyclo(L-Leu-L-Pro) 0
                    cyclo(L-arginyl-L-prolyl)(+1) 0
                    cyclo(Pro-Arg) 0
                    deoxybrevianamide E 0
                    maculosin 8
                    notoamide C 0
                    notoamide E 0
                    notoamide S + 0
                    peramine 0
                    tryprostatin A 0
                    tryprostatin B 0
                    zopiclone + 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      p-block molecular entity 19817
                        carbon group molecular entity 19757
                          organic molecular entity 19754
                            organic molecule 19706
                              organic cyclic compound 19495
                                organic heterocyclic compound 18874
                                  organic heteropolycyclic compound 18300
                                    organic heterobicyclic compound 17242
                                      pyrrolopyrazine 9
                                        (6S,8aS)-2-(benzylsulfonyl)-N-\{[1-(N'-hydroxycarbamimidoyl)piperidin-4-yl]methyl\}-4-oxooctahydropyrrolo[1,2-a]pyrazine-6-carboxamide 0
                                        (8aS)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione 0
                                        (S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one 0
                                        (S)-3-\{[2-(1,1-dimethylallyl)-indol-3-yl]methyl\}-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one 0
                                        1,2,3,4-tetrahydro-2-methyl-3-methylene-1,4-dioxopyrazino[1,2-a]indole 0
                                        1,3-Dimethylpyrrolo[1,2-a]pyrazine 0
                                        1,4-Dimethylpyrrolo[1,2-a]pyrazine 0
                                        1-Methylpyrrolo[1,2-a]pyrazine 0
                                        1-hydroxy-3-(indol-3-ylmethyl)-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazin-5-ylium 0
                                        1-hydroxy-3-\{[2-(1,1-dimethylallyl)-indol-3-yl]methyl\}-4H,6H,7H,8H-pyrrolo[1,2-a]pyrazin-2-ium 0
                                        1-hydroxy-3-\{[2-(1,1-dimethylallyl)-indol-3-yl]methyl\}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazin-5-ylium 0
                                        18-oxotryprostatin A 0
                                        2-\{3-[(3S,8aS)-1,4-dioxooctahydropyrrolo[1,2-a]pyrazin-3-yl]propyl\}guanidine 0
                                        3,4-Dimethylpyrrolo[1,2-a]pyrazine 0
                                        3-methylpyrrolo[1,2-a]pyrazine 0
                                        4-(7-butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl)phenol 0
                                        4-Methylpyrrolo[1,2-a]pyrazine 0
                                        6-hydroxydeoxybrevianamide E 0
                                        6-hydroxytryprostatin B 0
                                        7-Azaindolizine 0
                                        Brevianamide K 0
                                        Brevianamide S 0
                                        Brevianamide T 0
                                        Le-pyrrolopyrazine A 0
                                        Le-pyrrolopyrazine B 0
                                        Le-pyrrolopyrazine C 0
                                        Nannozinone A 0
                                        Nannozinone B 0
                                        Pyrocoll 0
                                        Sorazinone A 0
                                        brevianamide F + 0
                                        butyl (2S,3S)-3-(trans-4-aminocyclohexyl)-3-(\{[2-(benzylsulfonyl)-4-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-6-yl]carbonyl\}amino)-2-hydroxypropanoate 0
                                        cordysinin A 0
                                        cyclo(L-His-L-Pro) 0
                                        cyclo(L-Leu-L-Pro) 0
                                        cyclo(L-arginyl-L-prolyl)(+1) 0
                                        cyclo(Pro-Arg) 0
                                        deoxybrevianamide E 0
                                        maculosin 8
                                        notoamide C 0
                                        notoamide E 0
                                        notoamide S + 0
                                        peramine 0
                                        tryprostatin A 0
                                        tryprostatin B 0
                                        zopiclone + 1
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