CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: vinorelbine
Accession: CHEBI:480999
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Definition: A vinca alkaloid with a norvinblastine skeleton.
Synonyms: exact_synonym: methyl (2beta,3beta,4beta,5alpha,12beta,19alpha)-4-acetoxy-15-[(6R,8S)-4-ethyl-8-(methoxycarbonyl)-1,3,6,7,8,9-hexahydro-2,6-methanoazecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate
related_synonym: Formula=C45H54N4O8; InChI=1S/C45H54N4O8/c1-8-27-19-28-22-44(40(51)55-6,36-30(25-48(23-27)24-28)29-13-10-11-14-33(29)46-36)32-20-31-34(21-35(32)54-5)47(4)38-43(31)16-18-49-17-12-15-42(9-2,37(43)49)39(57-26(3)50)45(38,53)41(52)56-7/h10-15,19-21,28,37-39,46,53H,8-9,16-18,22-25H2,1-7H3/t28-,37-,38+,39+,42+,43+,44-,45-/m0/s1; InChIKey=GBABOYUKABKIAF-IELIFDKJSA-N; Nor-5'-anhydrovinblastine; SMILES=CCC1=C[C@@H]2CN(C1)Cc1c([nH]c3ccccc13)[C@@](C2)(C(=O)OC)c1cc2c(cc1OC)N(C)[C@@H]1[C@]22CCN3CC=C[C@](CC)([C@@H]23)[C@@H](OC(C)=O)[C@]1(O)C(=O)OC; vinorelbina; vinorelbinum
xref: Beilstein:9035861; CAS:71486-22-1; DrugBank:DB00361; Drug_Central:2827; KEGG:D08680
xref_mesh: MESH:C030852
xref: Patent:JP8031096; Patent:US4307100
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Casp3
caspase 3
multiple interactions
ISO
[pifithrin co-treated with vinorelbine] results in increased cleavage of and results in increased activity of CASP3 protein [Cisplatin co-treated with vinorelbine] results in increased activity of CASP3 protein
CTD
PMID:18516295 PMID:21544650
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp7
caspase 7
multiple interactions
ISO
[Cisplatin co-treated with vinorelbine] results in decreased expression of CASP7 mRNA
CTD
PMID:21544650
NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
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Cd40lg
CD40 ligand
multiple interactions
ISO
[Cisplatin co-treated with vinorelbine] results in decreased expression of CD40LG mRNA
CTD
PMID:21544650
NCBI chr X:135,127,052...135,138,768
Ensembl chr X:135,126,969...135,138,306
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Cdkn2a
cyclin-dependent kinase inhibitor 2A
decreases expression
ISO
vinorelbine results in decreased expression of CDKN2A protein
CTD
PMID:17904787
NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
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Epcam
epithelial cell adhesion molecule
multiple interactions increases expression
ISO
[vinorelbine co-treated with Cisplatin] results in increased expression of EPCAM protein vinorelbine results in increased expression of EPCAM protein
CTD
PMID:12695858
NCBI chr 6:6,880,142...6,896,103
Ensembl chr 6:6,878,237...6,896,127
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Fas
Fas cell surface death receptor
multiple interactions
ISO
[Cisplatin co-treated with vinorelbine] results in increased expression of FAS protein
CTD
PMID:21544650
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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Faslg
Fas ligand
multiple interactions
ISO
[Cisplatin co-treated with vinorelbine] results in decreased expression of FASL mRNA
CTD
PMID:21544650
NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
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Il10
interleukin 10
multiple interactions
ISO
[Cisplatin co-treated with vinorelbine] results in decreased expression of IL10 mRNA
CTD
PMID:21544650
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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Il7
interleukin 7
multiple interactions
ISO
[Cisplatin co-treated with vinorelbine] results in increased expression of IL7 protein
CTD
PMID:21544650
NCBI chr 2:94,235,219...94,280,075
Ensembl chr 2:94,234,766...94,280,075
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Krt18
keratin 18
increases expression increases metabolic processing
ISO
vinorelbine results in increased expression of KRT18 protein vinorelbine results in increased metabolism of KRT18 protein
CTD
PMID:16685278
NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166 Ensembl chr10:133,157,475...133,161,166
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Lhx4
LIM homeobox 4
multiple interactions
ISO
[Cisplatin co-treated with vinorelbine] results in decreased expression of LHX4 mRNA
CTD
PMID:21544650
NCBI chr13:67,877,109...67,917,219
Ensembl chr13:67,877,109...67,927,003
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Npm1
nucleophosmin 1
decreases response to substance
ISO
NPM1 protein results in decreased susceptibility to vinorelbine
CTD
PMID:24736981
NCBI chr10:17,741,512...17,751,626
Ensembl chr10:17,739,941...17,751,645 Ensembl chr X:17,739,941...17,751,645
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Nr1h4
nuclear receptor subfamily 1, group H, member 4
multiple interactions
ISO
vinorelbine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]
CTD
PMID:25257666
NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
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Pak5
p21 (RAC1) activated kinase 5
multiple interactions
ISO
[Cisplatin co-treated with Vinorelbine] results in decreased expression of PAK5 mRNA
CTD
PMID:21544650
NCBI chr 3:123,395,678...123,703,967
Ensembl chr 3:123,396,497...123,703,930
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Proc
protein C, inactivator of coagulation factors Va and VIIIa
decreases expression
ISO
vinorelbine results in decreased expression of PROC protein
CTD
PMID:10475134
NCBI chr18:23,764,367...23,774,816
Ensembl chr18:23,764,368...23,775,133
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Ptgs2
prostaglandin-endoperoxide synthase 2
decreases expression
ISO
vinorelbine results in decreased expression of PTGS2 protein
CTD
PMID:17904787
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Rbm17
RNA binding motif protein 17
decreases response to substance
ISO
RBM17 protein results in decreased susceptibility to vinorelbine
CTD
PMID:16061639
NCBI chr17:66,937,140...66,954,034
Ensembl chr17:66,937,140...66,954,014
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Slc29a1
solute carrier family 29 member 1
affects response to substance
ISO
SLC29A1 protein affects the susceptibility to vinorelbine
CTD
PMID:18452103
NCBI chr 9:15,399,661...15,414,203
Ensembl chr 9:15,399,612...15,414,203
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Tgfb1
transforming growth factor, beta 1
decreases activity
ISO
Vinorelbine results in decreased activity of TGFB1 protein
CTD
PMID:31652400
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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Tnf
tumor necrosis factor
multiple interactions
ISO
[Cisplatin co-treated with vinorelbine] results in decreased expression of TNF mRNA
CTD
PMID:21544650
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Traf1
TNF receptor-associated factor 1
multiple interactions
ISO
[Cisplatin co-treated with vinorelbine] results in decreased expression of TRAF1 mRNA
CTD
PMID:21544650
NCBI chr 3:18,222,024...18,242,163
Ensembl chr 3:18,222,054...18,241,807
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