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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:epibatidine
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Accession:CHEBI:4803 term browser browse the term
Definition:An alkaloid that has formula C11H13ClN2.
Synonyms:related_synonym: (1R,2R,4S)-2-(6-chloropyridin-3-yl)-7-azabicyclo[2.2.1]heptane;   CMI-488;   Formula=C11H13ClN2;   InChI=1S/C11H13ClN2/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8/h1,4,6,8-10,14H,2-3,5H2/t8?,9-,10+/m1/s1;   InChIKey=NLPRAJRHRHZCQQ-XVBQNVSMSA-N;   SMILES=C12C[C@@]([C@@H](N1)CC2)(C=3C=NC(=CC3)Cl)[H]
 alt_id: CHEBI:47399
 xref: CAS:140111-52-0;   DrugBank:DB07720;   KEGG:C11690;   KNApSAcK:C00028244
 xref_mesh: MESH:C082748
 xref: PDBeChem:EPJ;   PMID:16193063;   PMID:20337496;   PMID:21909087;   PMID:8112391;   Wikipedia:Epibatidine


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epibatidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrna1 cholinergic receptor nicotinic alpha 1 subunit multiple interactions EXP epibatidine binds to and results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]; LYNX1 protein promotes the reaction [epibatidine binds to and results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]]; LYPD1 protein promotes the reaction [epibatidine binds to and results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]] CTD PMID:19619141 NCBI chr 3:58,454,763...58,469,832
Ensembl chr 3:58,454,744...58,469,840 		JBrowse link
G Chrna2 cholinergic receptor nicotinic alpha 2 subunit multiple interactions
affects binding		 EXP
ISO		 epibatidine binds to and results in increased activity of [CHRNA2 protein binds to CHRNB2 protein]; sazetidine-A analog inhibits the reaction [epibatidine binds to and results in increased activity of [CHRNA2 protein binds to CHRNB2 protein]]
[CHRNB4 protein binds to CHRNA2 protein] which binds to epibatidine
Epibatidine binds to Chrna2 protein
epibatidine binds to Chrnb4 protein in the retina		 CTD
RGD		 PMID:9454827 PMID:21905669 PMID:15016836 PMID:16129735 RGD:2303194, RGD:2303195 NCBI chr15:40,342,317...40,358,601
Ensembl chr15:40,342,317...40,358,601 		JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit affects binding
multiple interactions		 ISO
EXP		 [CHRNB4 protein binds to CHRNA3 protein] which binds to epibatidine
2-(1'-methyl-2'-pyrrolidinyl)-7-hydroxy-1,4-benzodioxane inhibits the reaction [epibatidine binds to [CHRNA3 protein binds to CHRNB4 protein]]; epibatidine binds to and results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]
epibatidine binds to CHRNA3 protein
Tretinoin promotes the reaction [epibatidine binds to CHRNA3 protein]
[CHRNA3 protein binds to CHRNB4 protein] which binds to epibatidine; epibatidine binds to [CHRNA3 protein binds to CHRNB4 protein]
epibatidine analog binds to and results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]
Epibatidine binds to Chrna3 protein		 CTD
RGD		 PMID:9454827 PMID:9687574 PMID:15615518 PMID:17203487 PMID:21942635 More... RGD:2303194, RGD:2303195 NCBI chr 8:55,401,668...55,415,165
Ensembl chr 8:55,401,702...55,415,165 		JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions
affects binding		 ISO
EXP		 Acetylcholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Acetylthiocholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Alcuronium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Carbachol inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Choline inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; cytisine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; decamethonium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Dihydro-beta-Erythroidine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Dimethylphenylpiperazinium Iodide inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; epibatidine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; epibatidine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Hexamethonium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Lobeline inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; methyllycaconitine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Nicotine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Pancuronium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Physostigmine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; subecholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Succinylcholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Vecuronium Bromide inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]
[CHRNB4 protein binds to CHRNA4 protein] which binds to epibatidine; epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]
Tretinoin promotes the reaction [epibatidine binds to CHRNA4 protein]
2-(1'-methyl-2'-pyrrolidinyl)-7-hydroxy-1,4-benzodioxane inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; epibatidine binds to [CHRNA4 protein co-treated with CHRNB2 protein]; epibatidine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; sazetidine-A analog inhibits the reaction [epibatidine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]
Epibatidine binds to Chrna4 protein
epibatidine binds to Chrnb4 protein in the rat retina		 CTD
RGD		 PMID:9454827 PMID:10728888 PMID:11124396 PMID:14645658 PMID:15615518 More... RGD:2303194, RGD:2303195 NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957 		JBrowse link
G Chrna6 cholinergic receptor nicotinic alpha 6 subunit affects binding EXP epibatidine and alpha-Conotoxin MII bind to Chrna6 protein RGD PMID:22550286 RGD:8549526 NCBI chr16:64,697,741...64,704,441
Ensembl chr16:64,697,741...64,704,441 		JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit multiple interactions
affects binding
affects activity		 ISO
EXP		 1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea promotes the reaction [epibatidine affects the activity of CHRNA7 protein]; Bungarotoxins inhibits the reaction [epibatidine binds to CHRNA7 protein]; Carbachol inhibits the reaction [epibatidine binds to CHRNA7 protein]; methyllycaconitine inhibits the reaction [epibatidine binds to CHRNA7 protein]; PNU-282987 inhibits the reaction [epibatidine binds to CHRNA7 protein]; SAD-128 analog inhibits the reaction [epibatidine binds to CHRNA7 protein]
epibatidine inhibits the reaction [iodo-alpha-bungarotoxin binds to CHRNA7 protein]		 CTD PMID:19448648 PMID:21703337 PMID:29248576 NCBI chr 1:116,711,559...116,837,269
Ensembl chr 1:116,714,711...116,837,240 		JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions
affects binding		 ISO
EXP		 Acetylcholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Acetylthiocholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Alcuronium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Carbachol inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Choline inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; cytisine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; decamethonium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Dihydro-beta-Erythroidine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Dimethylphenylpiperazinium Iodide inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; epibatidine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; epibatidine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Hexamethonium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Lobeline inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; methyllycaconitine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Nicotine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Pancuronium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Physostigmine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; subecholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Succinylcholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Vecuronium Bromide inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]
2-(1'-methyl-2'-pyrrolidinyl)-7-hydroxy-1,4-benzodioxane inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; epibatidine binds to [CHRNA4 protein co-treated with CHRNB2 protein]; epibatidine binds to [NACHRALPHA1 protein co-treated with CHRNB2 protein]; epibatidine binds to [NACHRALPHA2 protein co-treated with CHRNB2 protein]; epibatidine binds to [NACHRALPHA3 protein co-treated with CHRNB2 protein]; epibatidine binds to and results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]; epibatidine binds to and results in increased activity of [CHRNA2 protein binds to CHRNB2 protein]; epibatidine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; epibatidine results in increased activity of [NACHRALPHA1 protein co-treated with CHRNB2 protein]; LYNX1 protein promotes the reaction [epibatidine binds to and results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]]; LYPD1 protein promotes the reaction [epibatidine binds to and results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]]; sazetidine-A analog inhibits the reaction [epibatidine binds to and results in increased activity of [CHRNA2 protein binds to CHRNB2 protein]]; sazetidine-A analog inhibits the reaction [epibatidine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]
Epibatidine binds to Chrnb2 protein
epibatidine binds to Chrnb4 protein in the rat retina		 CTD
RGD		 PMID:10728888 PMID:11124396 PMID:14645658 PMID:15615518 PMID:16291090 More... RGD:2303194, RGD:2303195 NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619 		JBrowse link
G Chrnb3 cholinergic receptor nicotinic beta 3 subunit affects binding EXP epibatidine binds to Chrnb4 protein in the rat retina RGD PMID:16129735 RGD:2303195 NCBI chr16:64,713,438...64,751,360
Ensembl chr16:64,714,169...64,751,360 		JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit affects binding
multiple interactions		 ISO
EXP		 [CHRNB4 protein binds to CHRNA2 protein] which binds to epibatidine; [CHRNB4 protein binds to CHRNA3 protein] which binds to epibatidine; [CHRNB4 protein binds to CHRNA4 protein] which binds to epibatidine
2-(1'-methyl-2'-pyrrolidinyl)-7-hydroxy-1,4-benzodioxane inhibits the reaction [epibatidine binds to [CHRNA3 protein binds to CHRNB4 protein]]; epibatidine binds to and results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]
[CHRNA3 protein binds to CHRNB4 protein] which binds to epibatidine; epibatidine binds to [CHRNA3 protein binds to CHRNB4 protein]
epibatidine analog binds to and results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]; epibatidine binds to [NACHRALPHA1 protein co-treated with CHRNB4 protein]; epibatidine binds to [NACHRALPHA2 protein co-treated with CHRNB4 protein]; epibatidine binds to [NACHRALPHA3 protein co-treated with CHRNB4 protein]
epibatidine binds to Chrnb4 protein in the retina		 CTD
RGD		 PMID:9454827 PMID:9687574 PMID:10728888 PMID:15615518 PMID:21942635 More... RGD:2303195 NCBI chr 8:55,417,583...55,437,027
Ensembl chr 8:55,418,313...55,437,027 		JBrowse link
G Chrnd cholinergic receptor nicotinic delta subunit multiple interactions EXP epibatidine binds to [NACHRALPHA3 protein co-treated with CHRND protein] CTD PMID:10728888 NCBI chr 9:87,862,417...87,870,833
Ensembl chr 9:87,862,407...87,870,833 		JBrowse link
G Chrng cholinergic receptor nicotinic gamma subunit multiple interactions EXP epibatidine binds to [NACHRALPHA3 protein co-treated with CHRNG protein] CTD PMID:10728888 NCBI chr 9:87,878,085...87,884,193
Ensembl chr 9:87,878,085...87,914,482 		JBrowse link
G Lynx1 Ly6/neurotoxin 1 multiple interactions EXP LYNX1 protein promotes the reaction [epibatidine binds to and results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]] CTD PMID:19619141 NCBI chr 7:106,632,800...106,638,003
Ensembl chr 7:106,632,797...106,638,023 		JBrowse link
G Lypd1 Ly6/Plaur domain containing 1 multiple interactions EXP LYPD1 protein promotes the reaction [epibatidine binds to and results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]] CTD PMID:19619141 NCBI chr13:37,326,459...37,368,515
Ensembl chr13:37,326,464...37,368,493 		JBrowse link
G Th tyrosine hydroxylase multiple interactions
increases expression		 EXP 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [epibatidine results in increased expression of TH mRNA]; 2',5'-dideoxyadenosine inhibits the reaction [epibatidine results in increased expression of TH mRNA] CTD PMID:15588622 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19867
    role 19837
      biological role 19835
        biochemical role 19552
          metabolite 19539
            alkaloid 8020
              epibatidine 14
Path 2
Term Annotations click to browse term
  CHEBI ontology 19867
    subatomic particle 19865
      composite particle 19865
        hadron 19865
          baryon 19865
            nucleon 19865
              atomic nucleus 19865
                atom 19865
                  main group element atom 19803
                    main group molecular entity 19803
                      p-block molecular entity 19803
                        carbon group molecular entity 19744
                          organic molecular entity 19740
                            heteroorganic entity 19512
                              organonitrogen compound 18832
                                alkaloid 8020
                                  epibatidine 14
paths to the root