|
G |
Glra1 |
glycine receptor, alpha 1 |
multiple interactions |
ISO |
n-butyl mercaptan promotes the reaction [Glycine Agents binds to and results in decreased activity of GLRA1 protein] |
CTD |
PMID:11049924 |
|
NCBI chr10:40,128,284...40,228,612
|
|
|
G |
Ace |
angiotensin I converting enzyme |
multiple interactions decreases activity |
EXP ISO |
Captopril inhibits the reaction [Pregabalin results in increased expression of ACE protein] Captopril inhibits the reaction [AGT protein results in increased expression of ACE mRNA]; Captopril inhibits the reaction [AGT protein results in increased expression of ACE protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of ACE mRNA]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of ACE protein] Captopril results in decreased activity of ACE protein |
CTD |
PMID:26851370 PMID:31629013 PMID:33007385 |
|
NCBI chr10:91,410,129...91,430,246
|
|
G |
Ace2 |
angiotensin converting enzyme 2 |
decreases response to substance multiple interactions |
ISO EXP |
ACE2 gene SNP results in decreased susceptibility to Captopril Captopril inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; Captopril inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]; Captopril inhibits the reaction [Silicon Dioxide results in decreased expression of ACE2 mRNA]; Captopril inhibits the reaction [Silicon Dioxide results in decreased expression of ACE2 protein] Captopril inhibits the reaction [Pregabalin results in decreased expression of ACE2 protein] |
CTD |
PMID:17473847 PMID:31629013 PMID:33007385 |
|
NCBI chr X:30,293,597...30,340,961
|
|
G |
Acta2 |
actin alpha 2, smooth muscle |
multiple interactions |
ISO EXP |
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; Captopril inhibits the reaction [AGT protein results in increased expression of ACTA2 protein] Captopril inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein] [goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein] |
CTD |
PMID:31181250 PMID:33007385 |
|
NCBI chr 1:241,159,723...241,172,503
|
|
G |
Agt |
angiotensinogen |
multiple interactions |
EXP ISO |
[icatibant co-treated with Captopril] inhibits the reaction [bisphenol A results in increased expression of AGT protein]; Captopril inhibits the reaction [bisphenol A results in increased expression of AGT protein]; Captopril inhibits the reaction [Pregabalin results in decreased expression of AGT protein] [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in decreased expression of GLI3 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in decreased expression of PTCH1 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of GLI1 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of GLI2 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of SHH protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of SMO protein]; Captopril inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; Captopril inhibits the reaction [Cadmium Chloride results in increased expression of AGT protein] Captopril inhibits the reaction [AGT protein results in decreased abundance of angiotensin I (1-7)]; Captopril inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; Captopril inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]; Captopril inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]; Captopril inhibits the reaction [AGT protein results in decreased expression of MAS1 protein]; Captopril inhibits the reaction [AGT protein results in increased expression of ACE mRNA]; Captopril inhibits the reaction [AGT protein results in increased expression of ACE protein]; Captopril inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; Captopril inhibits the reaction [AGT protein results in increased expression of AGT protein]; Captopril inhibits the reaction [AGT protein results in increased expression of AGTR1 protein]; Captopril inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]; Captopril inhibits the reaction [AGT protein results in increased expression of VIM protein]; Captopril inhibits the reaction [LEPR protein affects the expression of AGT protein]; Captopril inhibits the reaction [Silicon Dioxide results in decreased expression of AGT protein alternative form]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of AGT protein] |
CTD |
PMID:28130181 PMID:31181250 PMID:31629013 PMID:33007385 PMID:35844137 PMID:38027817 More...
|
|
NCBI chr19:69,426,540...69,447,017
|
|
G |
Agtr1a |
angiotensin II receptor, type 1a |
multiple interactions |
EXP ISO |
Captopril inhibits the reaction [Pregabalin results in increased expression of AGTR1 protein] Captopril inhibits the reaction [AGT protein results in increased expression of AGTR1 protein]; Captopril inhibits the reaction [LEPR protein affects the expression of AGTR1A mRNA]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of AGTR1 protein] |
CTD |
PMID:28130181 PMID:31629013 PMID:33007385 |
|
NCBI chr17:34,383,397...34,435,523
|
|
G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
ISO |
Captopril inhibits the reaction [Glucose results in increased expression of AKT1 mRNA] |
CTD |
PMID:38115276 |
|
NCBI chr 6:137,534,810...137,555,131
|
|
G |
Alpl |
alkaline phosphatase, biomineralization associated |
multiple interactions |
EXP |
Captopril inhibits the reaction [Methotrexate results in increased expression of and results in increased secretion of ALPL protein] |
CTD |
PMID:27269004 |
|
NCBI chr 5:155,234,770...155,289,785
|
|
G |
Bdkrb2 |
bradykinin receptor B2 |
multiple interactions |
ISO |
Captopril inhibits the reaction [LEPR protein affects the expression of BDKRB2 protein] |
CTD |
PMID:28130181 |
|
NCBI chr 6:130,237,055...130,267,205
|
|
G |
Calb1 |
calbindin 1 |
multiple interactions |
ISO |
Captopril promotes the reaction [LEPR protein affects the expression of CALB1 protein] |
CTD |
PMID:28130181 |
|
NCBI chr 5:29,375,624...29,402,532
|
|
G |
Car2 |
carbonic anhydrase 2 |
multiple interactions |
ISO |
Captopril promotes the reaction [LEPR protein affects the expression of CAR2 mRNA] |
CTD |
PMID:28130181 |
|
NCBI chr 2:88,462,883...88,478,012
|
|
G |
Casp3 |
caspase 3 |
multiple interactions |
EXP ISO |
Captopril inhibits the reaction [Methotrexate results in increased expression of CASP3 protein] Captopril inhibits the reaction [Glucose results in increased expression of CASP3 mRNA] |
CTD |
PMID:27269004 PMID:38115276 |
|
NCBI chr16:52,395,539...52,413,794
|
|
G |
Cdh1 |
cadherin 1 |
multiple interactions |
ISO |
Captopril inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]; Captopril inhibits the reaction [Silicon Dioxide results in decreased expression of CDH1 protein] |
CTD |
PMID:33007385 |
|
NCBI chr19:51,402,178...51,471,572
|
|
G |
Col3a1 |
collagen type III alpha 1 chain |
multiple interactions |
ISO |
Captopril inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of COL3A1 protein] |
CTD |
PMID:33007385 |
|
NCBI chr 9:54,866,646...54,902,578
|
|
G |
Gli1 |
GLI family zinc finger 1 |
multiple interactions |
EXP ISO |
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of GLI1 protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of GLI1 protein] [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of GLI1 protein] |
CTD |
PMID:31181250 |
|
NCBI chr 7:65,042,237...65,054,888
|
|
G |
Gli2 |
GLI family zinc finger 2 |
multiple interactions |
EXP ISO |
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of GLI2 protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of GLI2 protein] [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of GLI2 protein] |
CTD |
PMID:31181250 |
|
NCBI chr13:29,946,882...30,163,589
|
|
G |
Gli3 |
GLI family zinc finger 3 |
multiple interactions |
ISO EXP |
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in decreased expression of GLI3 protein] [goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in decreased expression of GLI3 protein]; Captopril inhibits the reaction [Silicon Dioxide results in decreased expression of GLI3 protein] |
CTD |
PMID:31181250 |
|
NCBI chr17:54,134,064...54,405,198
|
|
G |
Got1 |
glutamic-oxaloacetic transaminase 1 |
multiple interactions |
EXP |
Captopril inhibits the reaction [Methotrexate results in increased expression of and results in increased secretion of GOT1 protein] |
CTD |
PMID:27269004 |
|
NCBI chr 1:252,306,541...252,337,622
|
|
G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
EXP |
Captopril inhibits the reaction [Methotrexate results in increased expression of and results in increased secretion of GPT protein] |
CTD |
PMID:27269004 |
|
NCBI chr 7:110,295,599...110,300,134
|
|
G |
Il6 |
interleukin 6 |
multiple interactions |
EXP ISO |
[icatibant co-treated with Captopril] inhibits the reaction [bisphenol A results in increased expression of IL6 protein]; Captopril inhibits the reaction [bisphenol A results in increased expression of IL6 protein] Captopril inhibits the reaction [Glucose results in increased expression of IL6 mRNA] |
CTD |
PMID:38027817 PMID:38115276 |
|
NCBI chr 4:5,889,999...5,894,575
|
|
G |
Kng1 |
kininogen 1 |
multiple interactions |
EXP |
[icatibant co-treated with Captopril] inhibits the reaction [bisphenol A results in increased expression of KNG1 protein]; Captopril inhibits the reaction [bisphenol A results in increased expression of KNG1 protein] |
CTD |
PMID:38027817 |
|
NCBI chr11:77,812,757...77,835,555
|
|
G |
Lepr |
leptin receptor |
multiple interactions affects response to substance |
ISO |
Captopril inhibits the reaction [LEPR protein affects the expression of AGT protein]; Captopril inhibits the reaction [LEPR protein affects the expression of AGTR1A mRNA]; Captopril inhibits the reaction [LEPR protein affects the expression of BDKRB2 protein]; Captopril inhibits the reaction [LEPR protein affects the expression of PTH protein]; Captopril inhibits the reaction [LEPR protein affects the expression of VEGFA mRNA]; Captopril promotes the reaction [LEPR protein affects the expression of CALB1 protein]; Captopril promotes the reaction [LEPR protein affects the expression of CAR2 mRNA]; Captopril promotes the reaction [LEPR protein affects the expression of MMP9 mRNA]; Captopril promotes the reaction [LEPR protein affects the expression of RUNX2 mRNA]; Captopril promotes the reaction [LEPR protein affects the expression of VDR protein] LEPR protein affects the susceptibility to Captopril |
CTD |
PMID:28130181 |
|
NCBI chr 5:121,409,735...121,593,201
|
|
G |
Mas1 |
MAS1 proto-oncogene, G protein-coupled receptor |
multiple interactions |
EXP ISO |
Captopril inhibits the reaction [Pregabalin results in decreased expression of MAS1 protein] Captopril inhibits the reaction [AGT protein results in decreased expression of MAS1 protein]; Captopril inhibits the reaction [Silicon Dioxide results in decreased expression of MAS1 protein] |
CTD |
PMID:31629013 PMID:33007385 |
|
NCBI chr 1:50,428,064...50,459,537
|
|
G |
Mir146a |
microRNA 146a |
multiple interactions |
EXP |
captopril inhibits the reaction [ischemia-reperfusion injury increases expression of Mir146a miRNA in kidney] |
RGD |
PMID:27760486 |
RGD:155882556 |
NCBI chr10:28,349,996...28,350,090
|
|
G |
Mir320a |
microRNA 320a |
multiple interactions |
EXP |
captopril inhibits the reaction [ischemia-reperfusion injury increases expression of Mir320a miRNA in kidney] |
RGD |
PMID:27760486 |
RGD:155882556 |
NCBI chr15:45,516,392...45,516,473
|
|
G |
Mlkl |
mixed lineage kinase domain like pseudokinase |
multiple interactions |
ISO |
Captopril inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MLKL protein] |
CTD |
PMID:35844137 |
|
NCBI chr19:56,186,860...56,213,886
|
|
G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions |
ISO |
Captopril promotes the reaction [LEPR protein affects the expression of MMP9 mRNA] |
CTD |
PMID:28130181 |
|
NCBI chr 3:174,103,474...174,111,434
|
|
G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
EXP |
Captopril inhibits the reaction [Methotrexate results in increased expression of NOS2 protein] |
CTD |
PMID:27269004 |
|
NCBI chr10:64,313,335...64,349,221
|
|
G |
Nppb |
natriuretic peptide B |
multiple interactions |
EXP |
Captopril inhibits the reaction [Pregabalin results in increased expression of NPPB protein] |
CTD |
PMID:31629013 |
|
NCBI chr 5:163,699,955...163,701,314
|
|
G |
Prkaca |
protein kinase cAMP-activated catalytic subunit alpha |
multiple interactions |
EXP |
Captopril inhibits the reaction [Pregabalin results in decreased expression of PRKACA protein] |
CTD |
PMID:31629013 |
|
NCBI chr19:41,059,843...41,083,189
|
|
G |
Ptch1 |
patched 1 |
multiple interactions |
EXP ISO |
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in decreased expression of PTCH1 protein]; Captopril inhibits the reaction [Silicon Dioxide results in decreased expression of PTCH1 protein] [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in decreased expression of PTCH1 protein] |
CTD |
PMID:31181250 |
|
NCBI chr17:1,548,449...1,613,461
|
|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
EXP ISO |
Captopril inhibits the reaction [Methotrexate results in increased expression of PTGS2 protein] Captopril inhibits the reaction [Glucose results in increased expression of PTGS2 mRNA] |
CTD |
PMID:27269004 PMID:38115276 |
|
NCBI chr13:64,714,063...64,722,320
|
|
G |
Pth |
parathyroid hormone |
multiple interactions |
ISO |
Captopril inhibits the reaction [LEPR protein affects the expression of PTH protein] |
CTD |
PMID:28130181 |
|
NCBI chr 1:176,942,901...176,946,034
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
Captopril inhibits the reaction [Glucose results in increased phosphorylation of and results in increased localization of RELA protein] |
CTD |
PMID:38115276 |
|
NCBI chr 1:212,354,336...212,364,815
|
|
G |
Ripk3 |
receptor-interacting serine-threonine kinase 3 |
multiple interactions |
ISO |
Captopril inhibits the reaction [Cadmium Chloride results in increased expression of RIPK3 protein] |
CTD |
PMID:35844137 |
|
NCBI chr15:33,253,071...33,262,025
|
|
G |
Runx2 |
RUNX family transcription factor 2 |
multiple interactions |
ISO |
Captopril promotes the reaction [LEPR protein affects the expression of RUNX2 mRNA] |
CTD |
PMID:28130181 |
|
NCBI chr 9:23,661,278...23,990,248
|
|
G |
Shh |
sonic hedgehog signaling molecule |
multiple interactions |
ISO EXP |
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of SHH protein] [goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of SHH protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of SHH protein] |
CTD |
PMID:31181250 |
|
NCBI chr 4:6,954,017...6,963,170
|
|
G |
Smo |
smoothened, frizzled class receptor |
multiple interactions |
ISO EXP |
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of SMO protein] [goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of SMO protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of SMO protein] |
CTD |
PMID:31181250 |
|
NCBI chr 4:59,311,084...59,341,280
|
|
G |
Sod1 |
superoxide dismutase 1 |
multiple interactions |
EXP |
Captopril inhibits the reaction [Methotrexate results in decreased expression of and results in decreased activity of SOD1 protein] |
CTD |
PMID:27269004 |
|
NCBI chr11:42,942,742...42,948,399
|
|
G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
EXP |
[icatibant co-treated with Captopril] inhibits the reaction [bisphenol A results in increased expression of TGFB1 protein]; Captopril inhibits the reaction [bisphenol A results in increased expression of TGFB1 protein] |
CTD |
PMID:38027817 |
|
NCBI chr 1:90,324,312...90,340,627
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
EXP ISO |
[icatibant co-treated with Captopril] inhibits the reaction [bisphenol A results in increased expression of TNF protein]; Captopril inhibits the reaction [bisphenol A results in increased expression of TNF protein] Captopril inhibits the reaction [Glucose results in increased expression of TNF mRNA] |
CTD |
PMID:38027817 PMID:38115276 |
|
NCBI chr20:3,626,685...3,629,303
|
|
G |
Vcam1 |
vascular cell adhesion molecule 1 |
multiple interactions |
ISO |
Captopril inhibits the reaction [Glucose results in increased expression of VCAM1 mRNA] |
CTD |
PMID:38115276 |
|
NCBI chr 2:206,723,050...206,742,783
|
|
G |
Vdr |
vitamin D receptor |
multiple interactions |
ISO |
Captopril promotes the reaction [LEPR protein affects the expression of VDR protein] |
CTD |
PMID:28130181 |
|
NCBI chr 7:130,864,764...130,916,757
|
|
G |
Vegfa |
vascular endothelial growth factor A |
multiple interactions |
ISO |
Captopril inhibits the reaction [LEPR protein affects the expression of VEGFA mRNA] |
CTD |
PMID:28130181 |
|
NCBI chr 9:22,452,854...22,468,194
|
|
G |
Vim |
vimentin |
multiple interactions |
ISO |
Captopril inhibits the reaction [AGT protein results in increased expression of VIM protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of VIM protein] |
CTD |
PMID:33007385 |
|
NCBI chr17:81,577,261...81,585,746
|
|
|
G |
Ache |
acetylcholinesterase |
decreases activity |
ISO |
demeton-S-methyl results in decreased activity of ACHE protein |
CTD |
PMID:16766477 PMID:21238577 |
|
NCBI chr12:25,042,882...25,050,608
|
|
G |
Bche |
butyrylcholinesterase |
decreases activity |
ISO |
demeton-S-methyl results in decreased activity of BCHE protein |
CTD |
PMID:21238577 |
|
NCBI chr 2:160,607,289...160,699,760
|
|
|
G |
Acta2 |
actin alpha 2, smooth muscle |
multiple interactions |
ISO |
[Mercaptoethanol co-treated with Ascorbic Acid] results in increased expression of ACTA2 protein |
CTD |
PMID:17053324 |
|
NCBI chr 1:241,159,723...241,172,503
|
|
G |
Aqp1 |
aquaporin 1 |
multiple interactions |
ISO |
Mercaptoethanol inhibits the reaction [Mercury results in decreased activity of AQP1 protein] |
CTD |
PMID:24028651 |
|
NCBI chr 4:85,812,784...85,824,964
|
|
G |
Aqp11 |
aquaporin 11 |
multiple interactions |
ISO |
Mercaptoethanol inhibits the reaction [Mercuric Chloride inhibits the reaction [AQP11 protein results in increased transport of Water]] |
CTD |
PMID:21251984 |
|
NCBI chr 1:152,046,515...152,056,675
|
|
G |
Aqp3 |
aquaporin 3 (Gill blood group) |
multiple interactions |
ISO |
Mercaptoethanol inhibits the reaction [Mercuric Chloride inhibits the reaction [AQP3 protein results in increased transport of Water]] |
CTD |
PMID:9124401 |
|
NCBI chr 5:61,035,165...61,040,683
|
|
G |
Aqp7 |
aquaporin 7 |
multiple interactions |
ISO |
Mercaptoethanol inhibits the reaction [Mercuric Chloride results in decreased activity of AQP7 protein] |
CTD |
PMID:10777495 |
|
NCBI chr 5:56,171,649...56,186,642
|
|
G |
Casp1 |
caspase 1 |
multiple interactions |
ISO |
Mercaptoethanol inhibits the reaction [Ziram results in decreased expression of and results in increased degradation of CASP1 protein] |
CTD |
PMID:25929180 |
|
NCBI chr 8:10,746,338...10,882,295
|
|
G |
Cat |
catalase |
multiple interactions |
ISO |
CAT protein inhibits the reaction [Mercaptoethanol results in increased abundance of Hydrogen Peroxide] |
CTD |
PMID:7491977 |
|
NCBI chr 3:110,297,340...110,329,526
|
|
G |
Cyp7a1 |
cytochrome P450 family 7 subfamily A member 1 |
increases activity |
EXP |
Mercaptoethanol results in increased activity of CYP7A1 protein |
CTD |
PMID:1175606 |
|
NCBI chr 5:24,174,505...24,184,202
|
|
G |
Hmox1 |
heme oxygenase 1 |
multiple interactions |
ISO |
Mercaptoethanol inhibits the reaction [farrerol results in increased expression of HMOX1 protein] |
CTD |
PMID:26111761 |
|
NCBI chr19:13,452,365...13,479,823
|
|
G |
Il1a |
interleukin 1 alpha |
multiple interactions |
ISO |
[Mercaptoethanol co-treated with IL1A protein] results in increased expression of SOD2 protein; Mercaptoethanol promotes the reaction [IL1A protein results in increased expression of SOD2 mRNA] |
CTD |
PMID:7476933 |
|
NCBI chr 3:136,979,804...136,990,236
|
|
G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
ISO |
Mercaptoethanol inhibits the reaction [Sodium Selenite results in decreased activity of MAPK8 protein] |
CTD |
PMID:10644709 |
|
NCBI chr16:8,645,171...8,728,225
|
|
G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
Mercaptoethanol inhibits the reaction [Carbaryl inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]] |
CTD |
PMID:15907790 |
|
NCBI chr10:64,313,335...64,349,221
|
|
G |
Pigl |
phosphatidylinositol glycan anchor biosynthesis, class L |
affects response to substance |
ISO |
PIGL protein affects the susceptibility to Mercaptoethanol deficiency |
CTD |
PMID:25250048 |
|
NCBI chr10:47,142,160...47,199,892
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
increases activity |
ISO |
Mercaptoethanol results in increased activity of RELA protein |
CTD |
PMID:7491977 |
|
NCBI chr 1:212,354,336...212,364,815
|
|
G |
Rffl |
ring finger and FYVE-like domain containing E3 ubiquitin protein ligase |
affects response to substance |
ISO |
RFFL protein affects the susceptibility to Mercaptoethanol deficiency |
CTD |
PMID:25250048 |
|
NCBI chr10:68,238,273...68,301,225
|
|
G |
Slc2a1 |
solute carrier family 2 member 1 |
multiple interactions |
ISO |
Mercaptoethanol inhibits the reaction [[cinnamaldehyde co-treated with Glucose deficiency] results in decreased activity of SLC2A1 protein] |
CTD |
PMID:20955755 |
|
NCBI chr 5:138,002,522...138,030,742
|
|
G |
Slc39a10 |
solute carrier family 39 member 10 |
multiple interactions |
EXP |
Mercaptoethanol inhibits the reaction [SLC39A10 protein results in increased uptake of Zinc] |
CTD |
PMID:16804107 |
|
NCBI chr 9:62,331,281...62,454,754
|
|
G |
Slc3a2 |
solute carrier family 3 member 2 |
multiple interactions |
ISO |
Mercaptoethanol promotes the reaction [Mercuric Chloride inhibits the reaction [SLC3A2 protein results in increased uptake of Amino Acids, Peptides, and Proteins]] |
CTD |
PMID:9761775 |
|
NCBI chr 1:215,033,601...215,048,064
|
|
G |
Slc9a1 |
solute carrier family 9 member A1 |
multiple interactions |
ISO |
Mercaptoethanol affects the reaction [resveratrol results in decreased expression of SLC9A1 mRNA]; Mercaptoethanol affects the reaction [resveratrol results in decreased expression of SLC9A1 protein] |
CTD |
PMID:18951995 |
|
NCBI chr 5:145,576,341...145,629,630
|
|
G |
Sod1 |
superoxide dismutase 1 |
multiple interactions increases oxidation |
ISO |
Mercaptoethanol inhibits the reaction [[Copper co-treated with Hydrogen Peroxide] promotes the reaction [SOD1 protein binds to SOD1 protein]] Mercaptoethanol results in increased oxidation of SOD1 protein |
CTD |
PMID:15096637 |
|
NCBI chr11:42,942,742...42,948,399
|
|
G |
Sod2 |
superoxide dismutase 2 |
multiple interactions increases expression |
ISO |
[Mercaptoethanol co-treated with IL1A protein] results in increased expression of SOD2 protein; [Mercaptoethanol co-treated with TNF protein] results in increased expression of SOD2 protein; Mercaptoethanol promotes the reaction [IL1A protein results in increased expression of SOD2 mRNA]; Mercaptoethanol promotes the reaction [TNF protein results in increased expression of SOD2 mRNA]; TNF protein promotes the reaction [Mercaptoethanol results in increased expression of SOD2 mRNA] |
CTD |
PMID:7476933 |
|
NCBI chr 1:50,043,323...50,050,168
|
|
G |
Tiam1 |
TIAM Rac1 associated GEF 1 |
affects response to substance |
ISO |
TIAM1 protein affects the susceptibility to Mercaptoethanol deficiency |
CTD |
PMID:25250048 |
|
NCBI chr11:42,517,527...42,866,280
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
[Mercaptoethanol co-treated with TNF protein] results in increased expression of SOD2 protein; Mercaptoethanol promotes the reaction [TNF protein results in increased expression of SOD2 mRNA]; TNF protein promotes the reaction [Mercaptoethanol results in increased expression of SOD2 mRNA] |
CTD |
PMID:7476933 |
|
NCBI chr20:3,626,685...3,629,303
|
|
|
G |
Selenbp1 |
selenium binding protein 1 |
increases metabolic processing decreases metabolic processing |
ISO |
SELENBP1 protein results in increased metabolism of methylmercaptan SELENBP1 gene mutant form results in decreased metabolism of methylmercaptan |
CTD |
PMID:29255262 |
|
NCBI chr 2:182,494,004...182,504,594
|
|
|
G |
Ache |
acetylcholinesterase |
decreases activity |
ISO EXP |
Phorate metabolite results in decreased activity of ACHE protein; Phorate results in decreased activity of ACHE protein |
CTD |
PMID:30625376 PMID:33720374 |
|
NCBI chr12:25,042,882...25,050,608
|
|
G |
Alb |
albumin |
decreases expression |
EXP |
Phorate results in decreased expression of ALB protein |
CTD |
PMID:23280859 |
|
NCBI chr14:17,891,564...17,907,043
|
|
G |
Bche |
butyrylcholinesterase |
decreases expression |
EXP |
Phorate results in decreased expression of BCHE protein |
CTD |
PMID:23280859 |
|
NCBI chr 2:160,607,289...160,699,760
|
|
G |
Casp3 |
caspase 3 |
increases expression |
EXP |
Phorate results in increased expression of CASP3 mRNA; Phorate results in increased expression of CASP3 protein |
CTD |
PMID:22197610 |
|
NCBI chr16:52,395,539...52,413,794
|
|
G |
Casp9 |
caspase 9 |
increases expression |
EXP |
Phorate results in increased expression of CASP9 mRNA; Phorate results in increased expression of CASP9 protein |
CTD |
PMID:22197610 |
|
|
|
G |
Cat |
catalase |
multiple interactions decreases activity |
EXP |
[Phorate co-treated with acephate co-treated with Dichlorvos co-treated with Dimethoate] results in decreased activity of CAT protein Phorate results in decreased activity of CAT protein |
CTD |
PMID:22034174 |
|
NCBI chr 3:110,297,340...110,329,526
|
|
G |
Gpt |
glutamic--pyruvic transaminase |
increases expression |
EXP |
Phorate results in increased expression of GPT protein |
CTD |
PMID:23280859 |
|
NCBI chr 7:110,295,599...110,300,134
|
|
G |
Tp53 |
tumor protein p53 |
increases expression affects activity |
EXP ISO |
Phorate results in increased expression of TP53 mRNA; Phorate results in increased expression of TP53 protein Phorate metabolite affects the activity of TP53 protein |
CTD |
PMID:22197610 PMID:35435491 |
|
NCBI chr10:54,798,871...54,810,300
|
|
|
G |
Glra1 |
glycine receptor, alpha 1 |
multiple interactions |
ISO |
propanethiol promotes the reaction [Glycine Agents binds to and results in decreased activity of GLRA1 protein] |
CTD |
PMID:11049924 |
|
NCBI chr10:40,128,284...40,228,612
|
|
G |
Lta4h |
leukotriene A4 hydrolase |
multiple interactions |
ISO |
propanethiol inhibits the reaction [LTA4H protein results in increased chemical synthesis of Leukotriene B4]; propanethiol inhibits the reaction [LTA4H protein results in increased hydrolysis of Leukotriene A4] |
CTD |
PMID:2827578 |
|
NCBI chr 7:27,969,796...28,001,600
|
|
|
G |
Nr3c1 |
nuclear receptor subfamily 3, group C, member 1 |
multiple interactions |
EXP |
Dithiothreitol inhibits the reaction [methyl methanethiosulfonate inhibits the reaction [dexamethasone 21-methanesulfonate binds to NR3C1 protein]]; Dithiothreitol inhibits the reaction [methyl methanethiosulfonate inhibits the reaction [Dexamethasone binds to NR3C1 protein]]; methyl methanethiosulfonate inhibits the reaction [dexamethasone 21-methanesulfonate binds to NR3C1 protein]; methyl methanethiosulfonate inhibits the reaction [Dexamethasone binds to NR3C1 protein]; methyl methanethiosulfonate inhibits the reaction [NR3C1 protein binds to dexamethasone oxetanone] |
CTD |
PMID:1597467 PMID:2226332 |
|
NCBI chr18:31,522,783...31,644,508
|
|
G |
P2rx2 |
purinergic receptor P2X 2 |
multiple interactions |
EXP |
methyl methanethiosulfonate inhibits the reaction [Hydrogen Peroxide promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]]; methyl methanethiosulfonate inhibits the reaction [Mercury promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]] |
CTD |
PMID:19793987 |
|
NCBI chr12:46,338,979...46,342,891
|
|
G |
Pgr |
progesterone receptor |
decreases activity |
ISO |
methyl methanethiosulfonate results in decreased activity of PGR protein |
CTD |
PMID:9879984 |
|
NCBI chr 8:14,354,398...14,413,271
|
|
|
G |
Ap1s1 |
adaptor related protein complex 1 subunit sigma 1 |
decreases expression |
ISO |
Thioridazine results in decreased expression of AP1S1 mRNA |
CTD |
PMID:15342952 PMID:17175557 |
|
NCBI chr12:19,625,267...19,635,792
|
|
G |
Asah1 |
N-acylsphingosine amidohydrolase 1 |
increases expression |
ISO |
Thioridazine results in increased expression of ASAH1 mRNA |
CTD |
PMID:17175557 |
|
NCBI chr16:57,669,927...57,701,349
|
|
G |
Asns |
asparagine synthetase (glutamine-hydrolyzing) |
increases expression |
ISO |
Thioridazine results in increased expression of ASNS mRNA |
CTD |
PMID:17175557 |
|
NCBI chr 4:36,752,061...36,769,970
|
|
G |
Casp3 |
caspase 3 |
increases activity |
ISO |
Thioridazine results in increased activity of CASP3 protein |
CTD |
PMID:21035837 |
|
NCBI chr16:52,395,539...52,413,794
|
|
G |
Ccnd1 |
cyclin D1 |
decreases expression |
ISO |
Thioridazine results in decreased expression of CCND1 protein |
CTD |
PMID:21035837 |
|
NCBI chr 1:209,518,288...209,527,986
|
|
G |
Cdc25a |
cell division cycle 25A |
increases phosphorylation |
ISO |
Thioridazine results in increased phosphorylation of CDC25A protein |
CTD |
PMID:21035837 |
|
NCBI chr 8:118,742,824...118,761,190
|
|
G |
Cdk4 |
cyclin-dependent kinase 4 |
decreases expression |
ISO |
Thioridazine results in decreased expression of CDK4 protein |
CTD |
PMID:21035837 |
|
NCBI chr 7:64,771,453...64,774,891
|
|
G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression |
ISO |
Thioridazine results in increased expression of CDKN1A protein |
CTD |
PMID:21035837 |
|
NCBI chr20:7,150,820...7,161,373
|
|
G |
Cdkn2a |
cyclin-dependent kinase inhibitor 2A |
increases expression |
ISO |
Thioridazine results in increased expression of CDKN2A protein |
CTD |
PMID:21035837 |
|
NCBI chr 5:109,100,763...109,114,448
|
|
G |
Ces1d |
carboxylesterase 1D |
multiple interactions |
ISO |
Thioridazine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-nitrophenyl acetate]; Thioridazine inhibits the reaction [CES1 protein results in increased hydrolysis of Methylphenidate] |
CTD |
PMID:20097249 |
|
NCBI chr19:30,046,494...30,085,039
|
|
G |
Crh |
corticotropin releasing hormone |
decreases expression |
ISO |
Thioridazine results in decreased expression of CRH mRNA |
CTD |
PMID:16205782 |
|
NCBI chr 2:104,059,184...104,061,048
|
|
G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
multiple interactions |
ISO |
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Thioridazine; CYP1A2 protein results in increased metabolism of and results in increased activity of Thioridazine |
CTD |
PMID:19482014 PMID:23397584 |
|
NCBI chr 8:66,971,261...66,978,149
|
|
G |
Cyp2c6 |
cytochrome P450, family 2, subfamily C, polypeptide 6 |
multiple interactions decreases activity |
ISO |
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Thioridazine Thioridazine results in decreased activity of CYP2C19 protein |
CTD |
PMID:15135088 PMID:23397584 |
|
NCBI chr 1:247,879,058...247,916,804
|
|
G |
Cyp2d4 |
cytochrome P450, family 2, subfamily d, polypeptide 4 |
multiple interactions |
ISO |
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Thioridazine; CYP2D6 protein results in increased metabolism of and results in increased activity of Thioridazine |
CTD |
PMID:19482014 PMID:23397584 |
|
NCBI chr 7:115,762,662...115,771,832
|
|
G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
decreases activity |
ISO |
Thioridazine results in decreased activity of CYP2E1 protein |
CTD |
PMID:15135088 |
|
NCBI chr 1:205,269,967...205,280,365
|
|
G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
multiple interactions decreases activity |
ISO |
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Thioridazine Thioridazine results in decreased activity of CYP3A4 protein |
CTD |
PMID:15135088 PMID:23397584 |
|
NCBI chr12:14,321,771...14,343,886
|
|
G |
Depp1 |
DEPP autophagy regulator 1 |
increases expression |
ISO |
Thioridazine results in increased expression of DEPP1 mRNA |
CTD |
PMID:15342952 PMID:17175557 |
|
NCBI chr 4:149,910,794...149,913,013
|
|
G |
Eif4ebp1 |
eukaryotic translation initiation factor 4E binding protein 1 |
decreases phosphorylation |
ISO |
Thioridazine results in decreased phosphorylation of EIF4EBP1 protein |
CTD |
PMID:21035837 |
|
NCBI chr16:71,495,457...71,508,845
|
|
G |
Fabp1 |
fatty acid binding protein 1 |
increases expression |
ISO |
Thioridazine results in increased expression of FABP1 mRNA |
CTD |
PMID:15342952 PMID:17175557 |
|
NCBI chr 4:104,744,302...104,753,119
|
|
G |
Fndc4 |
fibronectin type III domain containing 4 |
increases expression |
ISO |
Thioridazine results in increased expression of FNDC4 mRNA |
CTD |
PMID:15342952 PMID:17175557 |
|
NCBI chr 6:25,077,155...25,080,812
|
|
G |
Gdpd3 |
glycerophosphodiester phosphodiesterase domain containing 3 |
increases expression |
ISO |
Thioridazine results in increased expression of GDPD3 mRNA |
CTD |
PMID:17175557 |
|
NCBI chr 1:181,373,505...181,383,063
|
|
G |
Hpn |
hepsin |
increases expression |
ISO |
Thioridazine results in increased expression of HPN mRNA |
CTD |
PMID:15342952 |
|
NCBI chr 1:86,337,085...86,352,785
|
|
G |
Inhbe |
inhibin subunit beta E |
increases expression |
ISO |
Thioridazine results in increased expression of INHBE mRNA |
CTD |
PMID:15342952 PMID:17175557 |
|
NCBI chr 7:65,061,531...65,064,519
|
|
G |
Kcnh2 |
potassium voltage-gated channel subfamily H member 2 |
multiple interactions decreases activity |
ISO |
Thioridazine inhibits the reaction [KCNH2 protein results in increased transport of Thallium] Thioridazine results in decreased activity of KCNH2 protein |
CTD |
PMID:15671647 PMID:16278312 PMID:21158687 PMID:24052561 |
|
NCBI chr 4:11,719,357...11,751,424
|
|
G |
Lss |
lanosterol synthase |
increases expression |
ISO |
Thioridazine results in increased expression of LSS mRNA |
CTD |
PMID:15342952 PMID:17175557 |
|
NCBI chr20:12,090,641...12,118,230
|
|
G |
Nr0b2 |
nuclear receptor subfamily 0, group B, member 2 |
increases expression |
ISO |
Thioridazine results in increased expression of NR0B2 mRNA |
CTD |
PMID:17175557 |
|
NCBI chr 5:145,779,294...145,782,609
|
|
G |
Nupr1 |
nuclear protein 1, transcriptional regulator |
increases expression |
ISO |
Thioridazine results in increased expression of NUPR1 mRNA |
CTD |
PMID:15342952 PMID:17175557 |
|
NCBI chr 1:190,643,866...190,645,901
|
|
G |
Phyh |
phytanoyl-CoA 2-hydroxylase |
increases expression |
ISO |
Thioridazine results in increased expression of PHYH mRNA |
CTD |
PMID:15342952 |
|
NCBI chr17:73,329,461...73,346,359
|
|
G |
Prl |
prolactin |
increases expression |
ISO |
Thioridazine results in increased expression of PRL protein |
CTD |
PMID:4065553 |
|
NCBI chr17:38,287,355...38,298,234
|
|
G |
Serpina3n |
serpin family A member 3N |
increases expression |
ISO |
Thioridazine results in increased expression of SERPINA3 mRNA |
CTD |
PMID:15342952 PMID:17175557 |
|
NCBI chr 6:123,323,623...123,331,181
|
|
G |
Slc22a2 |
solute carrier family 22 member 2 |
multiple interactions |
ISO |
Thioridazine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] |
CTD |
PMID:21599003 |
|
NCBI chr 1:50,668,817...50,711,019
|
|
G |
Slc2a3 |
solute carrier family 2 member 3 |
decreases expression |
ISO |
Thioridazine results in decreased expression of SLC2A3 mRNA |
CTD |
PMID:15342952 |
|
NCBI chr 4:157,632,887...157,698,034
|
|
G |
Tagln |
transgelin |
decreases expression |
ISO |
Thioridazine results in decreased expression of TAGLN mRNA |
CTD |
PMID:15342952 PMID:17175557 |
|
NCBI chr 8:55,121,647...55,127,121
|
|
G |
Tp53 |
tumor protein p53 |
affects activity |
ISO |
Thioridazine affects the activity of TP53 protein |
CTD |
PMID:35435491 |
|
NCBI chr10:54,798,871...54,810,300
|
|
G |
Wipi1 |
WD repeat domain, phosphoinositide interacting 1 |
increases expression |
ISO |
Thioridazine results in increased expression of WIPI1 mRNA |
CTD |
PMID:15342952 PMID:17175557 |
|
NCBI chr10:95,042,451...95,079,679
|
|
|
G |
Cat |
catalase |
increases expression |
ISO |
N-(2-mercaptoethyl)-1,3-diaminopropane results in increased expression of CAT protein |
CTD |
PMID:17388698 |
|
NCBI chr 3:110,297,340...110,329,526
|
|
G |
Ccl5 |
C-C motif chemokine ligand 5 |
increases expression |
ISO |
N-(2-mercaptoethyl)-1,3-diaminopropane results in increased expression of CCL5 mRNA |
CTD |
PMID:12007958 |
|
NCBI chr10:68,820,330...68,824,906
|
|
G |
Gstp1 |
glutathione S-transferase pi 1 |
decreases expression |
ISO |
N-(2-mercaptoethyl)-1,3-diaminopropane results in decreased expression of GSTP1 mRNA |
CTD |
PMID:12007958 |
|
NCBI chr 1:210,767,237...210,770,242
|
|
G |
Il2ra |
interleukin 2 receptor subunit alpha |
increases expression |
ISO |
N-(2-mercaptoethyl)-1,3-diaminopropane results in increased expression of IL2RA mRNA |
CTD |
PMID:12007958 |
|
NCBI chr17:66,849,974...66,898,665
|
|
G |
Myb |
MYB proto-oncogene, transcription factor |
increases expression |
ISO |
N-(2-mercaptoethyl)-1,3-diaminopropane results in increased expression of MYB mRNA |
CTD |
PMID:12007958 |
|
NCBI chr 1:15,939,771...15,973,367
|
|
G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
decreases expression |
ISO |
N-(2-mercaptoethyl)-1,3-diaminopropane results in decreased expression of MYC mRNA |
CTD |
PMID:12007958 |
|
NCBI chr 7:95,483,105...95,488,031
|
|
G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
ISO |
N-(2-mercaptoethyl)-1,3-diaminopropane results in increased activity of [NFKB1 protein binds to RELA protein]; N-(2-mercaptoethyl)-1,3-diaminopropane results in increased activity of [RELA protein binds to NFKB1 protein] |
CTD |
PMID:11390188 PMID:11917294 PMID:12007958 |
|
NCBI chr 2:226,689,745...226,805,897
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
N-(2-mercaptoethyl)-1,3-diaminopropane results in increased activity of [NFKB1 protein binds to RELA protein]; N-(2-mercaptoethyl)-1,3-diaminopropane results in increased activity of [RELA protein binds to NFKB1 protein] |
CTD |
PMID:11390188 PMID:11917294 PMID:12007958 |
|
NCBI chr 1:212,354,336...212,364,815
|
|
G |
Sod2 |
superoxide dismutase 2 |
increases expression increases activity multiple interactions |
ISO |
N-(2-mercaptoethyl)-1,3-diaminopropane results in increased expression of SOD2 mRNA; N-(2-mercaptoethyl)-1,3-diaminopropane results in increased expression of SOD2 protein N-(2-mercaptoethyl)-1,3-diaminopropane results in increased activity of SOD2 [TNFRSF1A protein co-treated with TNFRSF1B protein] affects the reaction [N-(2-mercaptoethyl)-1,3-diaminopropane results in increased activity of SOD2]; TNFRSF1A protein affects the reaction [N-(2-mercaptoethyl)-1,3-diaminopropane results in increased activity of SOD2] helenalin inhibits the reaction [N-(2-mercaptoethyl)-1,3-diaminopropane results in increased expression of SOD2 protein]; N-(2-mercaptoethyl)-1,3-diaminopropane results in increased expression of and results in increased activity of SOD2 protein |
CTD |
PMID:11390188 PMID:11917294 PMID:12007958 PMID:16540396 PMID:17388698 PMID:21945096 More...
|
|
NCBI chr 1:50,043,323...50,050,168
|
|
G |
Tnfrsf1a |
TNF receptor superfamily member 1A |
multiple interactions |
ISO |
[TNFRSF1A protein co-treated with TNFRSF1B protein] affects the reaction [N-(2-mercaptoethyl)-1,3-diaminopropane results in increased activity of SOD2]; TNFRSF1A protein affects the reaction [N-(2-mercaptoethyl)-1,3-diaminopropane results in increased activity of SOD2] |
CTD |
PMID:21945096 |
|
NCBI chr 4:159,837,119...159,849,817
|
|
G |
Tnfrsf1b |
TNF receptor superfamily member 1B |
multiple interactions |
ISO |
[TNFRSF1A protein co-treated with TNFRSF1B protein] affects the reaction [N-(2-mercaptoethyl)-1,3-diaminopropane results in increased activity of SOD2] |
CTD |
PMID:21945096 |
|
NCBI chr 5:157,070,642...157,104,216
|
|