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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:4'-epidoxorubicin
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Accession:CHEBI:47898 term browser browse the term
Definition:An anthracycline that is the 4'-epi-isomer of doxorubicin.
Synonyms:exact_synonym: (1S,3S)-3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-arabino-hexopyranoside
 related_synonym: 4'-Epiadriamycin;   Epiadriamycin;   Formula=C27H29NO11;   InChI=1S/C27H29NO11/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3/t10-,13-,15-,17-,22-,27-/m0/s1;   InChIKey=AOJJSUZBOXZQNB-VTZDEGQISA-N;   SMILES=COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO;   epirubicin;   epirubicina;   epirubicine;   epirubicinum;   pidorubicina;   pidorubicine;   pidorubicinum
 xref: Beilstein:1445812;   CAS:56420-45-2;   DrugBank:DB00445;   Drug_Central:1030;   KEGG:C11230;   KEGG:D07901;   LINCS:LSM-2078
 xref_mesh: MESH:D015251
 xref: PDBeChem:DM6;   PMID:11432615;   PMID:15821120;   PMID:16005104;   PMID:17604344;   PMID:18838875;   Patent:DE2510866;   Patent:US4058519;   Reaxys:1445812
 cyclic_relationship: is_conjugate_acid_of CHEBI:41983


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4'-epidoxorubicin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases expression		 ISO
EXP		 3',4',7-trihydroxyisoflavone inhibits the reaction [Epirubicin results in increased expression of ABCB1 mRNA]; [Epirubicin analog co-treated with chrysophsin analog] results in increased expression of ABCB1 mRNA; [Epirubicin co-treated with chrysophsin] results in increased expression of ABCB1 mRNA; ABCB1 protein affects the susceptibility to [Fluorouracil co-treated with Epirubicin co-treated with Cyclophosphamide]; formononetin inhibits the reaction [Epirubicin results in increased expression of ABCB1 mRNA]
Epirubicin analog results in increased expression of ABCB1 mRNA; Epirubicin results in increased expression of ABCB1 mRNA
[Diethylnitrosamine co-treated with Epirubicin] results in increased expression of ABCB1 protein		 CTD PMID:11818250 PMID:12576456 PMID:22914566 PMID:23867903 PMID:26335193 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions
decreases response to substance
increases expression		 ISO 3',4',7-trihydroxyisoflavone inhibits the reaction [Epirubicin results in increased expression of ABCC1 mRNA]; ABCC1 protein affects the susceptibility to [Fluorouracil co-treated with Epirubicin co-treated with Cyclophosphamide]; formononetin inhibits the reaction [Epirubicin results in increased expression of ABCC1 mRNA]
ABCC1 protein results in decreased susceptibility to Epirubicin
Epirubicin analog results in increased expression of ABCC1 mRNA; Epirubicin results in increased expression of ABCC1 mRNA		 CTD PMID:7954421 PMID:12576456 PMID:12657726 PMID:22914566 PMID:23867903 More... NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions
increases expression		 ISO 3',4',7-trihydroxyisoflavone inhibits the reaction [Epirubicin results in increased expression of ABCC2 mRNA]; formononetin inhibits the reaction [Epirubicin results in increased expression of ABCC2 mRNA]
Epirubicin analog results in increased expression of ABCC2 mRNA; Epirubicin results in increased expression of ABCC2 mRNA		 CTD PMID:22914566 PMID:23867903 PMID:26335193 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
decreases response to substance		 ISO ABCG2 protein affects the susceptibility to [Fluorouracil co-treated with Epirubicin co-treated with Cyclophosphamide]
ABCG2 protein results in decreased susceptibility to Epirubicin		 CTD PMID:10606239 PMID:12576456 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
increases phosphorylation		 ISO
EXP		 paeonol inhibits the reaction [Epirubicin results in decreased phosphorylation of AKT1 protein]
Epirubicin results in increased phosphorylation of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Epirubicin results in increased phosphorylation of AKT1 protein]; paeonol inhibits the reaction [Epirubicin results in increased phosphorylation of AKT1 protein]		 CTD PMID:26646421 PMID:29505745 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Ar androgen receptor multiple interactions ISO Epirubicin binds to and results in decreased activity of AR protein; Epirubicin binds to and results in increased activity of AR protein CTD PMID:25752796 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Atg5 autophagy related 5 decreases expression
multiple interactions		 EXP Epirubicin results in decreased expression of ATG5 protein
paeonol inhibits the reaction [Epirubicin results in decreased expression of ATG5 protein]; Sirolimus inhibits the reaction [Epirubicin results in decreased expression of ATG5 protein]		 CTD PMID:29505745 NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209 		JBrowse link
G Atg7 autophagy related 7 multiple interactions ISO [baicalein 5,6,7-trimethyl ether co-treated with Epirubicin] results in increased expression of ATG7 mRNA CTD PMID:38040128 NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression		 ISO 3',4',7-trihydroxyisoflavone promotes the reaction [Epirubicin results in increased expression of BAX mRNA]; [baicalein 5,6,7-trimethyl ether co-treated with Epirubicin] results in increased expression of BAX protein; [Epirubicin analog co-treated with chrysophsin analog] results in increased expression of BAX mRNA; chrysophsin promotes the reaction [Epirubicin results in increased expression of BAX mRNA]; Epirubicin promotes the reaction [3',4',7-trihydroxyisoflavone results in increased expression of BAX mRNA]; Epirubicin promotes the reaction [chrysophsin results in increased expression of BAX mRNA]; formononetin promotes the reaction [Epirubicin results in increased expression of BAX mRNA]
Epirubicin results in increased expression of BAX protein
paeonol inhibits the reaction [Epirubicin results in increased expression of BAX protein]		 CTD PMID:22914566 PMID:23867903 PMID:26335193 PMID:26646421 PMID:29505745 More... NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
multiple interactions
decreases expression		 ISO Epirubicin analog results in increased expression of BCL2 mRNA; Epirubicin results in increased expression of BCL2 mRNA
[Epirubicin analog co-treated with chrysophsin analog] results in increased expression of BCL2 mRNA; [Epirubicin co-treated with chrysophsin] results in increased expression of BCL2 mRNA
Epirubicin results in decreased expression of BCL2 protein
paeonol inhibits the reaction [Epirubicin results in decreased expression of BCL2 protein]		 CTD PMID:14503796 PMID:23867903 PMID:26335193 PMID:26646421 PMID:29505745 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Becn1 beclin 1 decreases expression
multiple interactions		 EXP
ISO		 Epirubicin results in decreased expression of BECN1 protein
paeonol inhibits the reaction [Epirubicin results in decreased expression of BECN1 protein]; Sirolimus inhibits the reaction [Epirubicin results in decreased expression of BECN1 protein]
[baicalein 5,6,7-trimethyl ether co-treated with Epirubicin] results in increased expression of BECN1 protein		 CTD PMID:29505745 PMID:38040128 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases response to substance
increases expression
multiple interactions		 ISO BIRC5 protein results in decreased susceptibility to Epirubicin
Epirubicin results in increased expression of BIRC5 protein
[Gossypol results in decreased phosphorylation of EIF4EBP1 protein] inhibits the reaction [Epirubicin results in increased expression of BIRC5 protein]; Gossypol inhibits the reaction [Epirubicin results in increased expression of BIRC5 protein]; MK 2206 inhibits the reaction [Epirubicin results in increased expression of BIRC5 protein]		 CTD PMID:16188142 PMID:35872041 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Birc6 baculoviral IAP repeat-containing 6 decreases response to substance ISO BIRC6 results in decreased susceptibility to Epirubicin CTD PMID:21542283 NCBI chr 6:20,722,922...20,916,396
Ensembl chr 6:20,722,922...20,916,434 		JBrowse link
G Casp1 caspase 1 increases response to substance ISO CASP1 results in increased susceptibility to Epirubicin CTD PMID:9491796 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases expression
increases cleavage		 ISO 3',4',7-trihydroxyisoflavone promotes the reaction [Epirubicin results in increased expression of CASP3 mRNA]; [Epirubicin analog co-treated with chrysophsin analog] results in increased expression of CASP3 mRNA; chrysophsin promotes the reaction [Epirubicin results in increased expression of CASP3 mRNA]; Epirubicin promotes the reaction [3',4',7-trihydroxyisoflavone results in increased activity of CASP3 protein]; Epirubicin promotes the reaction [3',4',7-trihydroxyisoflavone results in increased expression of CASP3 mRNA]; Epirubicin promotes the reaction [chrysophsin results in increased expression of CASP3 mRNA]; Epirubicin promotes the reaction [formononetin results in increased activity of CASP3 protein]; Epirubicin promotes the reaction [formononetin results in increased expression of CASP3 mRNA]; Epirubicin results in increased activity of and affects the localization of CASP3 protein; formononetin promotes the reaction [Epirubicin results in increased activity of CASP3 protein]; formononetin promotes the reaction [Epirubicin results in increased expression of CASP3 mRNA]
Epirubicin results in increased cleavage of CASP3 protein
paeonol inhibits the reaction [Epirubicin results in increased cleavage of CASP3 protein]		 CTD PMID:14503796 PMID:15996160 PMID:22914566 PMID:23867903 PMID:26335193 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO Epirubicin promotes the reaction [formononetin results in increased activity of CASP8 protein]; Epirubicin promotes the reaction [formononetin results in increased expression of CASP8 mRNA] CTD PMID:23867903 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
increases expression		 ISO 3',4',7-trihydroxyisoflavone promotes the reaction [Epirubicin results in increased expression of CASP9 mRNA]; [Epirubicin analog co-treated with chrysophsin analog] results in increased expression of CASP9 mRNA; chrysophsin promotes the reaction [Epirubicin results in increased expression of CASP9 mRNA]; Epirubicin promotes the reaction [3',4',7-trihydroxyisoflavone results in increased activity of CASP9 protein]; Epirubicin promotes the reaction [3',4',7-trihydroxyisoflavone results in increased expression of CASP9 mRNA]; Epirubicin promotes the reaction [chrysophsin results in increased expression of CASP9 mRNA]; Epirubicin promotes the reaction [formononetin results in increased activity of CASP9 protein]; Epirubicin promotes the reaction [formononetin results in increased expression of CASP9 mRNA]; formononetin promotes the reaction [Epirubicin results in increased activity of CASP9 protein]; formononetin promotes the reaction [Epirubicin results in increased expression of CASP9 mRNA] CTD PMID:22914566 PMID:23867903 PMID:26335193 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase decreases activity
multiple interactions		 ISO
EXP		 Epirubicin results in decreased activity of CAT protein
paeonol inhibits the reaction [Epirubicin results in decreased activity of CAT protein]
3-(indol-3-yl)propionic acid inhibits the reaction [Epirubicin results in decreased activity of CAT protein]		 CTD PMID:26646421 PMID:36822302 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccn2 cellular communication network factor 2 increases expression
multiple interactions		 ISO Epirubicin results in increased expression of CCN2 mRNA
Lovastatin inhibits the reaction [Epirubicin results in increased expression of CCN2 mRNA]		 CTD PMID:22712078 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Dpyd dihydropyrimidine dehydrogenase multiple interactions ISO DPYD protein affects the susceptibility to [Fluorouracil co-treated with Epirubicin] CTD PMID:16646564 NCBI chr 2:206,609,043...207,474,982
Ensembl chr 2:206,609,122...207,474,982 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO EGFR protein affects the susceptibility to [Epirubicin co-treated with CMF regimen] CTD PMID:18768436 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions
increases phosphorylation		 ISO [Gossypol results in decreased phosphorylation of EIF4EBP1 protein] inhibits the reaction [Epirubicin results in increased expression of BIRC5 protein]; Gossypol inhibits the reaction [Epirubicin results in increased phosphorylation of EIF4EBP1 protein]; MK 2206 inhibits the reaction [Epirubicin results in increased phosphorylation of EIF4EBP1 protein] CTD PMID:35872041 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 multiple interactions ISO ERBB2 protein affects the susceptibility to [Epirubicin co-treated with CMF regimen]; ERBB2 protein affects the susceptibility to [Fluorouracil co-treated with Epirubicin co-treated with Cyclophosphamide] CTD PMID:16446318 PMID:16682728 PMID:18768436 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078 		JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 multiple interactions ISO ERBB3 protein affects the susceptibility to [Epirubicin co-treated with CMF regimen] CTD PMID:18768436 NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Epirubicin binds to and results in decreased activity of ESR1 protein CTD PMID:25752796 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO Epirubicin binds to and results in decreased activity of ESR2 protein CTD PMID:25752796 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Fas Fas cell surface death receptor increases expression EXP Epirubicin results in increased expression of FAS protein CTD PMID:19429229 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Faslg Fas ligand increases expression EXP Epirubicin results in increased expression of FASLG protein; Epirubicin results in increased expression of FASLG protein modified form CTD PMID:19429229 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fkbpl FKBP prolyl isomerase like increases expression ISO Epirubicin results in increased expression of FKBPL mRNA CTD PMID:14503796 NCBI chr20:4,099,845...4,101,315
Ensembl chr20:4,099,806...4,101,368 		JBrowse link
G Fshb follicle stimulating hormone subunit beta decreases expression
multiple interactions		 EXP Epirubicin results in decreased expression of FSHB protein
3-(indol-3-yl)propionic acid inhibits the reaction [Epirubicin results in decreased expression of FSHB protein]		 CTD PMID:36822302 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370 		JBrowse link
G Il2 interleukin 2 increases expression
multiple interactions		 ISO Epirubicin results in increased expression of IL2 mRNA; Epirubicin results in increased expression of IL2 protein
paeonol inhibits the reaction [Epirubicin results in increased expression of IL2 mRNA]; paeonol inhibits the reaction [Epirubicin results in increased expression of IL2 protein]		 CTD PMID:26646421 PMID:29505745 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions		 ISO Epirubicin results in increased expression of IL6 protein
paeonol inhibits the reaction [Epirubicin results in increased expression of IL6 mRNA]		 CTD PMID:17914082 PMID:19060235 PMID:26646421 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Il6r interleukin 6 receptor increases expression ISO Epirubicin results in increased expression of IL6R protein CTD PMID:19060235 NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO Gossypol inhibits the reaction [Epirubicin results in increased phosphorylation of MAPK1 protein] CTD PMID:35872041 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO Gossypol inhibits the reaction [Epirubicin results in increased phosphorylation of MAPK3 protein] CTD PMID:35872041 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Marveld1 MARVEL domain containing 1 increases response to substance ISO MARVELD1 protein results in increased susceptibility to Epirubicin CTD PMID:31205918 NCBI chr 1:240,954,050...240,958,101
Ensembl chr 1:240,954,452...240,958,384 		JBrowse link
G Mir1 microRNA 1 decreases expression
multiple interactions		 EXP Epirubicin results in decreased expression of MIR1 mRNA
paeonol inhibits the reaction [Epirubicin results in decreased expression of MIR1 mRNA]		 CTD PMID:29505745 NCBI chr18:1,887,537...1,887,623 JBrowse link
G Mpo myeloperoxidase increases activity
multiple interactions		 EXP Epirubicin results in increased activity of MPO protein
3-(indol-3-yl)propionic acid inhibits the reaction [Epirubicin results in increased activity of MPO protein]		 CTD PMID:36822302 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Mtor mechanistic target of rapamycin kinase increases phosphorylation
multiple interactions		 EXP Epirubicin results in increased phosphorylation of MTOR protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Epirubicin results in increased phosphorylation of MTOR protein]; paeonol inhibits the reaction [Epirubicin results in increased phosphorylation of MTOR protein]		 CTD PMID:29505745 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO Epirubicin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NR1H4 protein affects the localization of NCOA2 protein]] CTD PMID:25257666 NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP Epirubicin results in decreased expression of and results in increased phosphorylation of NFKBIA protein; paeonol inhibits the reaction [Epirubicin results in decreased expression of and results in increased phosphorylation of NFKBIA protein]; prolinedithiocarbamate inhibits the reaction [Epirubicin results in decreased expression of and results in increased phosphorylation of NFKBIA protein] CTD PMID:29505745 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nppa natriuretic peptide A increases expression ISO Epirubicin results in increased expression of NPPA protein CTD PMID:1831809 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO Epirubicin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NR1H4 protein affects the localization of NCOA2 protein]]; Epirubicin inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]; Epirubicin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Epirubicin inhibits the reaction [Rifampin results in increased activity of NR1I2 protein] CTD PMID:29356861 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions		 ISO Epirubicin results in increased cleavage of PARP1 protein
paeonol inhibits the reaction [Epirubicin results in increased cleavage of PARP1 protein]
[Gossypol co-treated with Epirubicin] results in increased cleavage of PARP1 protein		 CTD PMID:26646421 PMID:35872041 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pgr progesterone receptor multiple interactions ISO Epirubicin binds to and results in decreased activity of PGR protein CTD PMID:25752796 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Phlda2 pleckstrin homology-like domain, family A, member 2 increases response to substance ISO PHLDA2 results in increased susceptibility to Epirubicin CTD PMID:22021909 NCBI chr 1:198,696,897...198,699,292
Ensembl chr 1:198,696,897...198,697,836 		JBrowse link
G Pml PML nuclear body scaffold affects mutagenesis ISO Epirubicin affects the mutagenesis of PML gene CTD PMID:19884644 NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971 		JBrowse link
G Prl prolactin increases expression
multiple interactions		 EXP Epirubicin results in increased expression of PRL protein
3-(indol-3-yl)propionic acid inhibits the reaction [Epirubicin results in increased expression of PRL protein]		 CTD PMID:36822302 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Rara retinoic acid receptor, alpha affects mutagenesis ISO Epirubicin affects the mutagenesis of RARA gene CTD PMID:19884644 NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases phosphorylation		 EXP paeonol inhibits the reaction [Epirubicin results in increased phosphorylation of RELA protein]; prolinedithiocarbamate inhibits the reaction [Epirubicin results in increased phosphorylation of RELA protein] CTD PMID:29505745 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions
increases phosphorylation		 ISO Gossypol inhibits the reaction [Epirubicin results in increased phosphorylation of RPS6KB1 protein]; MK 2206 inhibits the reaction [Epirubicin results in increased phosphorylation of RPS6KB1 protein] CTD PMID:35872041 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Sod2 superoxide dismutase 2 affects response to substance ISO SOD2 protein affects the susceptibility to Epirubicin CTD PMID:9569045 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
increases expression		 EXP paeonol inhibits the reaction [Epirubicin results in increased expression of SQSTM1 protein]; Sirolimus inhibits the reaction [Epirubicin results in increased expression of SQSTM1 protein] CTD PMID:29505745 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO [baicalein 5,6,7-trimethyl ether co-treated with Epirubicin] results in decreased expression of TGFB1 mRNA CTD PMID:38040128 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO Epirubicin binds to and results in decreased activity of THRA protein CTD PMID:25752796 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936 		JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO Epirubicin binds to and results in decreased activity of THRB protein CTD PMID:25752796 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions		 ISO Epirubicin results in increased expression of TNF mRNA; Epirubicin results in increased expression of TNF protein
paeonol inhibits the reaction [Epirubicin results in increased expression of TNF mRNA]; paeonol inhibits the reaction [Epirubicin results in increased expression of TNF protein]		 CTD PMID:26646421 PMID:29505745 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Top2a DNA topoisomerase II alpha multiple interactions ISO TOP2A protein affects the susceptibility to [Cyclophosphamide co-treated with Epirubicin co-treated with Fluorouracil]; TOP2A protein affects the susceptibility to [Fluorouracil co-treated with Epirubicin co-treated with Cyclophosphamide] CTD PMID:16682728 PMID:18465341 NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression		 ISO 3',4',7-trihydroxyisoflavone promotes the reaction [Epirubicin results in increased expression of TP53 mRNA]; [Epirubicin analog co-treated with chrysophsin analog] results in increased expression of TP53 mRNA; chrysophsin promotes the reaction [Epirubicin results in increased expression of TP53 mRNA]; Epirubicin promotes the reaction [3',4',7-trihydroxyisoflavone results in increased expression of TP53 mRNA]; Epirubicin promotes the reaction [chrysophsin results in increased expression of TP53 mRNA] CTD PMID:22914566 PMID:26335193 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tshb thyroid stimulating hormone subunit beta multiple interactions
decreases expression		 EXP 3-(indol-3-yl)propionic acid inhibits the reaction [Epirubicin results in decreased expression of TSHB protein] CTD PMID:36822302 NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559 		JBrowse link
G Tymp thymidine phosphorylase multiple interactions ISO [Epirubicin co-treated with Cyclophosphamide] results in increased expression of TYMP protein CTD PMID:15150550 NCBI chr 7:120,438,768...120,444,088
Ensembl chr 7:120,438,770...120,443,874
Ensembl chr 7:120,438,770...120,443,874 		JBrowse link
G Vegfc vascular endothelial growth factor C multiple interactions ISO VEGFC mRNA results in increased susceptibility to [Paclitaxel co-treated with Epirubicin co-treated with CMF regimen] CTD PMID:23146280 NCBI chr16:37,712,251...37,827,845
Ensembl chr16:37,712,262...37,827,848 		JBrowse link
G Xdh xanthine dehydrogenase increases activity
multiple interactions		 EXP Epirubicin results in increased activity of XDH protein
3-(indol-3-yl)propionic acid inhibits the reaction [Epirubicin results in increased activity of XDH protein]		 CTD PMID:36822302 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19854
      biological role 19852
        antimicrobial agent 18266
          4'-epidoxorubicin 64
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    p-block element atom 19849
                      carbon group element atom 19766
                        carbon atom 19785
                          organic molecular entity 19785
                            heteroorganic entity 19541
                              organochalcogen compound 19301
                                organooxygen compound 19193
                                  carbonyl compound 18937
                                    ketone 17268
                                      oxyketone 8910
                                        alpha-oxyketone 8918
                                          alpha-hydroxy ketone 8918
                                            primary alpha-hydroxy ketone 7792
                                              doxorubicin 7572
                                                4'-epidoxorubicin 64
paths to the root