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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:enalaprilat (anhydrous)
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Accession:CHEBI:4786 term browser browse the term
Definition:Enalapril in which the ethyl ester group has been hydrolysed to the corresponding carboxylic acid. Enalaprilat is an angiotensin-converting enzyme (ACE) inhibitor and is used (often in the form of its prodrug, enalapril) in the treatment of hypertension and heart failure, for reduction of proteinuria and renal disease in patients with nephropathies, and for the prevention of stroke, myocardial infarction, and cardiac death in high-risk patients. Unlike enalapril, enalaprilat is not absorbed by mouth but is given by intravenous injection, usually as the dihydrate.
Synonyms:related_synonym: N-[(1S)-1-carboxy-3-phenylpropyl]-L-alanyl-L-proline;   enalapril acid;   enalapril diacid;   enalaprilat;   enalaprilate;   enalaprilatum
 alt_id: CHEBI:123355
 xref: Beilstein:3656856;   CAS:76420-72-9;   DrugBank:DB00584;   Patent:EP12401;   Patent:US4374829;   kegg.compound:C11720;   lincs.smallmolecule:LSM-6026;   pdb-ccd:EAL
 chemrof_formula: C18H24N2O5
 chemrof_smiles: C[C@H](N[C@@H](CCc1ccccc1)C(=O)O)C(=O)N1CCC[C@H]1C(=O)O
 chemrof_inchi: InChI=1S/C18H24N2O5/c1-12(16(21)20-11-5-8-15(20)18(24)25)19-14(17(22)23)10-9-13-6-3-2-4-7-13/h2-4,6-7,12,14-15,19H,5,8-11H2,1H3,(H,22,23)(H,24,25)/t12-,14-,15-/m0/s1
 chemrof_inchikey: LZFZMUMEGBBDTC-QEJZJMRPSA-N


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enalaprilat dihydrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme multiple interactions ISO Enalaprilat inhibits the reaction [Glucose results in increased expression of ACE protein] CTD PMID:16452552 NCBI chr10:91,410,129...91,430,246
Ensembl chr10:91,409,819...91,430,942 		JBrowse link
G Adrb1 adrenoceptor beta 1 affects expression EXP Enalaprilat affects the expression of ADRB1 protein CTD PMID:9260993 NCBI chr 1:265,777,103...265,780,114
Ensembl chr 1:265,766,079...265,849,237 		JBrowse link
G Adrb2 adrenoceptor beta 2 affects expression EXP Enalaprilat affects the expression of ADRB2 protein CTD PMID:9260993 NCBI chr18:57,912,760...57,914,802
Ensembl chr18:57,911,348...57,914,803 		JBrowse link
G Agt angiotensinogen decreases expression
multiple interactions 		EXP
ISO 		Enalaprilat results in decreased expression of AGT protein modified form
Enalaprilat inhibits the reaction [Glucose results in increased expression of AGT protein] 		CTD PMID:16452552 PMID:21795644 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions ISO Enalaprilat inhibits the reaction [Glucose results in increased expression of AGTR1 protein] CTD PMID:16452552 NCBI chr17:34,383,397...34,435,523
Ensembl chr17:34,381,467...34,435,660 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression ISO Enalaprilat results in increased expression of BCL2 mRNA CTD PMID:17342403 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Bdkrb1 bradykinin receptor B1 multiple interactions
increases activity 		ISO bradykinin, Lys-Leu(8)-desArg(9)- inhibits the reaction [Enalaprilat results in increased activity of BDKRB1 protein]; Zinc affects the reaction [Enalaprilat results in increased activity of BDKRB1 protein] CTD PMID:11880373 NCBI chr 6:130,275,631...130,284,968
Ensembl chr 6:130,275,478...130,280,973 		JBrowse link
G Edn1 endothelin 1 decreases secretion ISO Enalaprilat results in decreased secretion of EDN1 protein CTD PMID:19079593 NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,660,799...22,666,687 		JBrowse link
G Fn1 fibronectin 1 decreases expression
multiple interactions 		EXP
ISO 		Enalaprilat results in decreased expression of FN1 mRNA; Enalaprilat results in decreased expression of FN1 protein
Enalaprilat inhibits the reaction [Glucose results in increased expression of FN1 mRNA] 		CTD PMID:14520012 PMID:21795644 NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:80,645,507...80,714,137 		JBrowse link
G Glud1 glutamate dehydrogenase 1 multiple interactions EXP Enalaprilat inhibits the reaction [Dexamethasone results in decreased expression of GLUD1 mRNA] CTD PMID:32494933 NCBI chr16:9,646,569...9,680,215
Ensembl chr16:9,646,509...9,680,210 		JBrowse link
G Grid2 glutamate ionotropic receptor delta type subunit 2 multiple interactions EXP Enalaprilat inhibits the reaction [Dexamethasone results in decreased expression of GLUD2 mRNA] CTD PMID:32494933 NCBI chr 4:93,745,165...95,222,354
Ensembl chr 4:93,745,277...95,219,868 		JBrowse link
G Grm1 glutamate metabotropic receptor 1 multiple interactions EXP Enalaprilat inhibits the reaction [Dexamethasone results in increased expression of GRM1 mRNA] CTD PMID:32494933 NCBI chr 1:6,878,542...7,273,447
Ensembl chr 1:6,878,545...7,273,443 		JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions EXP Enalaprilat inhibits the reaction [Dexamethasone results in increased expression of HMGB1 mRNA]; Enalaprilat inhibits the reaction [Dexamethasone results in increased expression of HMGB1 protein] CTD PMID:32494933 NCBI chr12:11,009,236...11,015,941
Ensembl chr16:39,039,050...39,041,327
Ensembl chr12:39,039,050...39,041,327 		JBrowse link
G Ins2 insulin 2 multiple interactions ISO Enalaprilat inhibits the reaction [Glucose results in decreased secretion of INS protein] CTD PMID:16452552 NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:207,272,742...207,273,805 		JBrowse link
G Ppard peroxisome proliferator-activated receptor delta multiple interactions EXP [Enalaprilat co-treated with Daunorubicin] results in increased expression of PPARD mRNA CTD PMID:23834779 NCBI chr20:6,300,527...6,365,707
Ensembl chr20:6,352,183...6,365,707 		JBrowse link
G Ren renin increases expression EXP Enalaprilat results in increased expression of REN mRNA CTD PMID:21795644 NCBI chr13:47,348,312...47,359,539
Ensembl chr13:47,348,143...47,359,543 		JBrowse link
G Serpine1 serpin family E member 1 decreases expression EXP Enalaprilat results in decreased expression of SERPINE1 mRNA CTD PMID:21795644 NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions
increases uptake 		ISO verlukast inhibits the reaction [SLC22A8 protein results in increased uptake of Enalaprilat] CTD PMID:33007874 NCBI chr 1:214,925,506...214,945,516
Ensembl chr 1:214,925,508...214,946,588 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression EXP Enalaprilat results in decreased expression of TGFB1 mRNA; Enalaprilat results in decreased expression of TGFB1 protein CTD PMID:21795644 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP Enalaprilat inhibits the reaction [Dexamethasone results in increased expression of TLR4 mRNA] CTD PMID:32494933 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007 		JBrowse link
G Tnf tumor necrosis factor decreases expression ISO Enalaprilat results in decreased expression of TNF mRNA CTD PMID:17342403 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    role 20844
      application 20572
        pharmaceutical 20359
          drug 20359
            cardiovascular drug 8214
              antihypertensive agent 1962
                enalaprilat (anhydrous) 20
                  enalaprilat dihydrate 21
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      carbon group element atom 20712
                        carbon atom 20706
                          organic molecular entity 20706
                            heteroorganic entity 20201
                              organochalcogen compound 19822
                                organooxygen compound 19713
                                  carboxamide 17697
                                    peptide 11484
                                      oligopeptide 1362
                                        dipeptide 407
                                          enalaprilat (anhydrous) 20
                                            enalaprilat dihydrate 21
paths to the root