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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:11-oxo steroid
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Accession:CHEBI:47787 term browser browse the term
Definition:Any oxo steroid that has an oxo substituent at position 11.
Synonyms:related_synonym: 11-Oxosteroid;   11-oxo steroids;   11-oxosteroids;   Formula=C19H29OR;   SMILES=C12(CCCCC1CCC3C2C(CC4(C3CCC4*)C)=O)C;   an 11-oxosteroid
 alt_id: CHEBI:13773;   CHEBI:19127;   CHEBI:725
 xref: KEGG:C01985


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11-dehydrocorticosterone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 increases metabolic processing
increases reduction
affects abundance
multiple interactions
affects response to substance		 ISO
EXP		 HSD11B1 protein results in increased metabolism of 11-dehydrocorticosterone
HSD11B1 protein results in increased reduction of 11-dehydrocorticosterone
HSD11B1 gene mutant form affects the abundance of 11-dehydrocorticosterone
[HSD11B1 protein results in increased oxidation of Corticosterone] which results in increased chemical synthesis of 11-dehydrocorticosterone; [HSD11B1 protein results in increased reduction of 11-dehydrocorticosterone] which results in increased chemical synthesis of Corticosterone; Resveratrol inhibits the reaction [HSD11B1 protein results in increased metabolism of 11-dehydrocorticosterone]; Ziram inhibits the reaction [[HSD11B1 protein results in increased reduction of 11-dehydrocorticosterone] which results in increased chemical synthesis of Corticosterone]; Ziram inhibits the reaction [HSD11B1 protein results in increased reduction of 11-dehydrocorticosterone]
HSD11B1 gene affects the susceptibility to 11-dehydrocorticosterone		 CTD PMID:16751407 PMID:23814014 PMID:25061560 PMID:26859423 NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687 		JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 multiple interactions EXP [HSD11B2 protein results in increased metabolism of Corticosterone] which results in increased chemical synthesis of 11-dehydrocorticosterone; [HSD11B2 protein results in increased oxidation of Corticosterone] which results in increased chemical synthesis of 11-dehydrocorticosterone; Ziram inhibits the reaction [[HSD11B2 protein results in increased oxidation of Corticosterone] which results in increased chemical synthesis of 11-dehydrocorticosterone] CTD PMID:26859423 PMID:32243540 NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899 		JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions		 ISO 11-dehydrocorticosterone results in increased expression of IL6 mRNA
11-dehydrocorticosterone promotes the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]		 CTD PMID:30993381 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 multiple interactions
increases expression		 EXP Carbenoxolone inhibits the reaction [11-dehydrocorticosterone results in increased expression of SGK1 mRNA]; Tetradecanoylphorbol Acetate promotes the reaction [11-dehydrocorticosterone results in increased expression of SGK1 mRNA] CTD PMID:16533503 NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283 		JBrowse link
adrenosterone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO adrenosterone inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
cortisone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO [Calcitriol co-treated with Cortisone] results in decreased expression of ADIPOQ mRNA CTD PMID:19918113 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Akr1d1 aldo-keto reductase family 1, member D1 multiple interactions ISO [AKR1D1 protein co-treated with NADP] results in increased reduction of Cortisone CTD PMID:25500266 NCBI chr 4:66,154,246...66,187,505
Ensembl chr 4:66,154,248...66,186,372 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP Cortisone inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein] CTD PMID:15755911 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO Cortisone results in increased expression of CCL2 mRNA CTD PMID:24135201 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Dhrs7 dehydrogenase/reductase 7 increases reduction ISO DHRS7 protein results in increased reduction of Cortisone CTD PMID:24246760 NCBI chr 6:91,332,259...91,347,856
Ensembl chr 6:91,251,323...91,347,892 		JBrowse link
G Fabp4 fatty acid binding protein 4 increases expression
multiple interactions		 ISO Cortisone results in increased expression of FABP4 mRNA
2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone inhibits the reaction [Cortisone results in increased expression of FABP4 mRNA]		 CTD PMID:21315688 NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578 		JBrowse link
G Glul glutamate-ammonia ligase increases activity EXP Cortisone results in increased activity of GLUL protein CTD PMID:30993381 NCBI chr13:65,969,053...66,035,121
Ensembl chr13:66,025,630...66,035,108 		JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 multiple interactions
increases expression
increases reduction
affects response to substance
increases metabolic processing
affects metabolic processing		 ISO
EXP		 [Calcitriol co-treated with Cortisone] results in increased expression of HSD11B1 mRNA; [HSD11B1 protein results in increased activity of Cortisone] inhibits the reaction [sulforaphane results in increased activity of NFE2L2 protein]; [HSD11B1 protein results in increased oxidation of Hydrocortisone] which results in increased chemical synthesis of Cortisone; [HSD11B1 protein results in increased reduction of Cortisone] which results in increased chemical synthesis of Hydrocortisone; [Mifepristone binds to and results in decreased activity of NR3C1 protein] inhibits the reaction [[HSD11B1 protein results in increased activity of Cortisone] inhibits the reaction [sulforaphane results in increased activity of NFE2L2 protein]]
Cortisone results in increased expression of HSD11B1 mRNA
2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone inhibits the reaction [Cortisone results in increased expression of and results in increased activity of HSD11B1 protein]; Cortisone results in increased expression of and results in increased activity of HSD11B1 protein
[HSD11B1 protein affects the susceptibility to Cortisone] which results in decreased activity of NFE2L2 protein; [HSD11B1 protein co-treated with Cortisone] results in decreased expression of NQO1 mRNA; Cortisone promotes the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA]
HSD11B1 protein results in increased metabolism of Cortisone
HSD11B1 protein affects the metabolism of Cortisone		 CTD PMID:16054388 PMID:16751407 PMID:19918113 PMID:21315688 PMID:22606287 More... NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687 		JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 increases chemical synthesis
multiple interactions		 ISO HSD11B2 protein results in increased chemical synthesis of Cortisone
[HSD11B2 protein results in increased oxidation of Hydrocortisone] which results in increased chemical synthesis of Cortisone; Ziram inhibits the reaction [[HSD11B2 protein results in increased oxidation of Hydrocortisone] which results in increased chemical synthesis of Cortisone]		 CTD PMID:22796344 PMID:26859423 NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression		 ISO perfluorooctane sulfonic acid inhibits the reaction [Cortisone results in decreased expression of IL1B] CTD PMID:27288094 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 decreases expression
multiple interactions		 ISO Cortisone results in decreased expression of IL6
perfluorooctane sulfonic acid inhibits the reaction [Cortisone results in decreased expression of IL6]		 CTD PMID:27288094 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Cortisone results in increased phosphorylation of MAPK1 protein CTD PMID:24135201 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Cortisone results in increased phosphorylation of MAPK3 protein CTD PMID:24135201 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO
EXP		 [HSD11B1 protein results in increased activity of Cortisone] inhibits the reaction [sulforaphane results in increased activity of NFE2L2 protein]; [Mifepristone binds to and results in decreased activity of NR3C1 protein] inhibits the reaction [[HSD11B1 protein results in increased activity of Cortisone] inhibits the reaction [sulforaphane results in increased activity of NFE2L2 protein]]
[HSD11B1 protein affects the susceptibility to Cortisone] which results in decreased activity of NFE2L2 protein		 CTD PMID:22606287 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression ISO Cortisone results in increased expression of NOS2 protein CTD PMID:24135201 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP [HSD11B1 protein co-treated with Cortisone] results in decreased expression of NQO1 mRNA CTD PMID:22606287 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 affects binding
multiple interactions
increases activity		 ISO Cortisone binds to NR3C1 protein
[Mifepristone binds to and results in decreased activity of NR3C1 protein] inhibits the reaction [[HSD11B1 protein results in increased activity of Cortisone] inhibits the reaction [sulforaphane results in increased activity of NFE2L2 protein]]
Cortisone results in increased activity of NR3C1 protein		 CTD PMID:15705660 PMID:15780662 PMID:22606287 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 increases activity ISO Cortisone results in increased activity of NR3C2 protein CTD PMID:15780662 NCBI chr19:30,715,634...31,059,885
Ensembl chr19:30,715,648...31,059,885 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases expression		 ISO 2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone inhibits the reaction [Cortisone results in increased expression of PPARG mRNA] CTD PMID:21315688 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO Cortisone results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases phosphorylation ISO Cortisone results in increased phosphorylation of RELA protein CTD PMID:24135201 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 increases expression
multiple interactions		 EXP Cortisone results in increased expression of SGK1 mRNA
Phenylephrine promotes the reaction [Cortisone results in increased expression of SGK1 mRNA]; Tetradecanoylphorbol Acetate promotes the reaction [Cortisone results in increased expression of SGK1 mRNA]		 CTD PMID:16533503 NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Cortisone inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 increases expression
multiple interactions		 ISO Cortisone results in increased expression of SLC2A4 mRNA
2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone inhibits the reaction [Cortisone results in increased expression of SLC2A4 mRNA]		 CTD PMID:21315688 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565 		JBrowse link
G Tnf tumor necrosis factor increases expression ISO Cortisone results in increased expression of TNF mRNA CTD PMID:24135201 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
prednisone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin decreases expression ISO Prednisone results in decreased expression of A2M protein CTD PMID:11304663 NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
affects response to substance
increases secretion		 ISO Elacridar inhibits the reaction [ABCB1 protein results in increased secretion of Prednisone]; valspodar inhibits the reaction [ABCB1 protein results in increased secretion of Prednisone]
ABCB1A protein affects the susceptibility to Prednisone		 CTD PMID:15502009 PMID:22464980 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B affects response to substance ISO ABCB1B protein affects the susceptibility to Prednisone CTD PMID:15502009 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions
increases activity		 ISO Prednisone promotes the reaction [ABCC3 protein affects the transport of calcein AM]
Prednisone results in increased activity of ABCC3 protein		 CTD PMID:15979871 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO [Prednisone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein CTD PMID:29782964 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases expression ISO Prednisone results in decreased expression of AKT1 mRNA CTD PMID:38439560 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alb albumin decreases expression ISO Prednisone results in decreased expression of ALB mRNA CTD PMID:38439560 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Ar androgen receptor multiple interactions ISO Prednisone binds to and results in increased activity of AR protein mutant form CTD PMID:11956172 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression ISO Prednisone results in decreased expression of BAX mRNA CTD PMID:38439560 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Casp9 caspase 9 decreases expression ISO Prednisone results in decreased expression of CASP9 mRNA CTD PMID:38439560 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccl11 C-C motif chemokine ligand 11 decreases expression ISO Prednisone results in decreased expression of CCL11 protein CTD PMID:15523430 NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926 		JBrowse link
G Ccl12 C-C motif chemokine ligand 12 decreases expression ISO Prednisone results in decreased expression of CCL13 protein CTD PMID:15523430 NCBI chr10:67,070,230...67,071,780
Ensembl chr10:67,070,230...67,071,780 		JBrowse link
G Cd2ap CD2-associated protein multiple interactions EXP Prednisone affects the reaction [Doxorubicin results in increased expression of CD2AP mRNA]; Prednisone inhibits the reaction [Doxorubicin results in increased expression of CD2AP protein] CTD PMID:16636307 NCBI chr 9:18,086,744...18,182,744
Ensembl chr 9:18,086,984...18,182,199 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Prednisone results in increased expression of CDKN1A protein CTD PMID:15034294 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO Prednisone results in increased expression of CDKN1B protein CTD PMID:15034294 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A increases expression ISO Prednisone results in increased expression of CDKN2A protein CTD PMID:15034294 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B increases expression ISO Prednisone results in increased expression of CDKN2B protein CTD PMID:15034294 NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:104,010,680...104,019,050 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha affects expression
decreases expression		 ISO Prednisone affects the expression of CEBPA mRNA
Prednisone results in decreased expression of CEBPA protein		 CTD PMID:38439560 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A decreases expression ISO Prednisone results in decreased expression of CPT1A mRNA CTD PMID:38439560 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 decreases expression ISO Prednisone results in decreased expression of CXCL12 mRNA CTD PMID:38439560 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168 		JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 increases expression ISO Prednisone results in increased expression of CYP27A1 mRNA CTD PMID:38439560 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551 		JBrowse link
G Dlk1 delta like non-canonical Notch ligand 1 decreases expression ISO Prednisone results in decreased expression of DLK1 mRNA CTD PMID:38439560 NCBI chr 6:128,410,216...128,417,518
Ensembl chr 6:128,410,316...128,417,522 		JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions ISO [Prednisone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein CTD PMID:29782964 NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578 		JBrowse link
G Gcg glucagon multiple interactions
decreases expression		 EXP [Fatty Acids, Unsaturated co-treated with Prednisone] results in increased expression of GCG mRNA
Prednisone results in decreased expression of GCG mRNA		 CTD PMID:12524409 PMID:14705828 NCBI chr 3:47,113,914...47,122,958
Ensembl chr 3:47,113,914...47,122,929 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 affects response to substance ISO GSTM1 gene polymorphism affects the susceptibility to Prednisone CTD PMID:15713801 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases activity ISO Prednisone results in increased activity of HIF1A protein CTD PMID:19502547 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha decreases expression ISO Prednisone results in decreased expression of HNF4A mRNA; Prednisone results in decreased expression of HNF4A protein CTD PMID:38439560 NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320 		JBrowse link
G Ifng interferon gamma multiple interactions ISO [zafirlukast co-treated with Prednisone co-treated with Budesonide] inhibits the reaction [Antigens results in increased secretion of IFNG protein] CTD PMID:16160912 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression ISO Prednisone results in decreased expression of IGF1 mRNA CTD PMID:38439560 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Il12a interleukin 12A multiple interactions ISO Prednisone results in increased expression of [IL12A protein binds to IL12B protein] CTD PMID:19584951 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734 		JBrowse link
G Il12b interleukin 12B multiple interactions ISO Prednisone results in increased expression of [IL12A protein binds to IL12B protein] CTD PMID:19584951 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il13 interleukin 13 decreases expression ISO Prednisone results in decreased expression of IL13 protein CTD PMID:15523430 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Il4 interleukin 4 decreases expression ISO Prednisone results in decreased expression of IL4 protein CTD PMID:19584951 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il5 interleukin 5 decreases expression ISO Prednisone results in decreased expression of IL5 protein CTD PMID:12722970 PMID:15523430 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213 		JBrowse link
G Ins2 insulin 2 multiple interactions ISO [Prednisone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein; [Prednisone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein CTD PMID:29782964 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Itgb1 integrin subunit beta 1 decreases expression ISO Prednisone results in decreased expression of ITGB1 mRNA CTD PMID:38439560 NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases expression EXP Prednisone results in decreased expression of JUN mRNA CTD PMID:12524409 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Krt19 keratin 19 increases expression ISO Prednisone results in increased expression of KRT19 mRNA CTD PMID:38439560 NCBI chr10:85,075,835...85,080,552
Ensembl chr10:85,066,802...85,171,799 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 decreases expression ISO Prednisone results in decreased expression of MAP2K1 mRNA CTD PMID:38439560 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147 		JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 decreases expression ISO Prednisone results in decreased expression of MAP2K2 mRNA CTD PMID:38439560 NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases expression ISO Prednisone results in decreased expression of MAPK1 mRNA CTD PMID:38439560 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases expression ISO Prednisone results in decreased expression of MAPK3 mRNA CTD PMID:38439560 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO Prednisone results in decreased expression of MKI67 mRNA CTD PMID:38439560 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Nphs2 NPHS2 stomatin family member, podocin multiple interactions EXP Prednisone inhibits the reaction [Doxorubicin results in increased expression of NPHS2 mRNA] CTD PMID:16636307 NCBI chr13:68,448,720...68,461,312
Ensembl chr13:68,448,926...68,461,313 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO Prednisone binds to and results in increased activity of NR3C1 protein CTD PMID:28973534 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 increases expression ISO Prednisone results in increased expression of PCK1 mRNA CTD PMID:38439560 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191 		JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO Prednisone results in decreased expression of PCNA mRNA; Prednisone results in decreased expression of PCNA protein CTD PMID:38439560 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Plat plasminogen activator, tissue type increases expression ISO Prednisone results in increased expression of PLAT protein CTD PMID:10452346 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223 		JBrowse link
G Pomc proopiomelanocortin decreases expression ISO Prednisone results in decreased expression of POMC protein modified form CTD PMID:1977371 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression ISO Prednisone results in decreased expression of PPARA mRNA CTD PMID:38439560 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Prom1 prominin 1 decreases expression ISO Prednisone results in decreased expression of PROM mRNA CTD PMID:38439560 NCBI chr14:66,989,545...67,094,534
Ensembl chr14:66,990,160...67,094,527 		JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C decreases expression ISO Prednisone results in decreased expression of PTPRC mRNA CTD PMID:38439560 NCBI chr13:49,596,193...49,708,283
Ensembl chr13:49,596,193...49,708,692 		JBrowse link
G Pygm glycogen phosphorylase, muscle associated decreases expression ISO Prednisone results in decreased expression of PYGM protein CTD PMID:8815173 NCBI chr 1:203,690,550...203,705,369
Ensembl chr 1:203,690,533...203,705,368 		JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO Prednisone results in decreased phosphorylation of and results in decreased activity of RB1 protein CTD PMID:15034294 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Serpinc1 serpin family C member 1 increases expression ISO Prednisone results in increased expression of SERPINC1 protein CTD PMID:11304663 NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Prednisone inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Sox9 SRY-box transcription factor 9 affects expression ISO Prednisone affects the expression of SOX9 mRNA CTD PMID:38439560 NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994 		JBrowse link
G Spmip11 sperm microtubule inner protein 11 multiple interactions EXP Prednisone inhibits the reaction [Doxorubicin results in decreased phosphorylation of NPHS1 protein]; Prednisone inhibits the reaction [Doxorubicin results in increased expression of NPHS1 protein] CTD PMID:16636307 PMID:19293598 NCBI chr 7:129,720,950...129,742,485
Ensembl chr 7:129,720,950...129,742,485 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression ISO Prednisone results in decreased expression of TGFB1 protein CTD PMID:12722970 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor increases expression ISO Prednisone results in increased expression of TNF protein CTD PMID:19584951 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tyms thymidylate synthetase affects response to substance ISO TYMS gene polymorphism affects the susceptibility to Prednisone CTD PMID:15713801 NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536 		JBrowse link
G Vdr vitamin D receptor increases expression
affects response to substance		 ISO Prednisone results in increased expression of VDR protein
VDR gene polymorphism affects the susceptibility to Prednisone		 CTD PMID:7662588 PMID:15713801 NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP Prednisone affects the reaction [Doxorubicin results in decreased expression of VEGFA protein] CTD PMID:19293598 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
RU 5135 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Glra1 glycine receptor, alpha 1 multiple interactions ISO RU 5135 binds to and results in decreased activity of GLRA1 protein CTD PMID:15081878 NCBI chr10:39,625,853...39,727,897
Ensembl chr10:39,629,459...39,727,162 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    chemical entity 19872
      group 19825
        inorganic group 19404
          oxo group 18908
            organic oxo compound 18908
              carbonyl compound 18908
                ketone 17258
                  oxo steroid 10532
                    11-oxo steroid 81
                      (17Z)-3,11-dioxopregna-4,17(20)-dien-21-oic acid methyl ester 0
                      (22S, 23R)-12alpha,14alpha,23alpha-trihydroxy-16,22-epoxy-ergosta-4,8-dien-3,11-dione 0
                      11,21-dioxoprogesterone 0
                      11-dehydrocorticosterone 4
                      11-oxotestosterone 0
                      16beta-Hydroxy-3,11-dioxopregna-4,17(20)-dien-21-oic acid, gamma-lactone 0
                      20(21)-dehydrolucidenic acid A 0
                      20(21)-dehydrolucidenic acid N 0
                      20alpha-dihydroprednisone 0
                      20beta-dihydroprednisone 0
                      20beta-hydroxycortisone 0
                      21-dehydrocortisone 0
                      3alpha,21-dihydroxy-D-homo-5beta-pregn-17a(20)-en-11-one 0
                      4,5-dihydrocortisone + 0
                      6alpha-hydroxyprednisone 0
                      6beta-hydroxycortisone 0
                      6beta-hydroxyprednisone 0
                      9-fluoro-2alpha-methylpregn-4-ene-3,11,20-trione 0
                      Aphidicolin A3 0
                      Asperfloroid 0
                      Asperflosterol 0
                      Cucurbitacin S 0
                      Delta(6)-prednisone 0
                      Emesterone A 0
                      Emesterone B 0
                      Ganodernoid C 0
                      Ganoluciduone A 0
                      Lucidenic acid O 0
                      Mer-NF8054X 0
                      Ochrasperfloroid 0
                      RU 5135 1
                      adrenosterone 1
                      cortancyl 0
                      cortisone + 25
                      ganolucidic acid D 0
                      methyl 20(21)-dehydrolucidenate A 0
                      prednisone + 62
                      zhankuic acid A + 0
                      zhankuic acid A methyl ester 0
                      zhankuic acid B 0
                      zhankuic acid C 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      carbon group element atom 19751
                        carbon atom 19748
                          organic molecular entity 19748
                            heteroorganic entity 19505
                              organochalcogen compound 19268
                                organooxygen compound 19184
                                  carbonyl compound 18908
                                    ketone 17258
                                      oxo steroid 10532
                                        11-oxo steroid 81
                                          (17Z)-3,11-dioxopregna-4,17(20)-dien-21-oic acid methyl ester 0
                                          (22S, 23R)-12alpha,14alpha,23alpha-trihydroxy-16,22-epoxy-ergosta-4,8-dien-3,11-dione 0
                                          11,21-dioxoprogesterone 0
                                          11-dehydrocorticosterone 4
                                          11-oxotestosterone 0
                                          16beta-Hydroxy-3,11-dioxopregna-4,17(20)-dien-21-oic acid, gamma-lactone 0
                                          20(21)-dehydrolucidenic acid A 0
                                          20(21)-dehydrolucidenic acid N 0
                                          20alpha-dihydroprednisone 0
                                          20beta-dihydroprednisone 0
                                          20beta-hydroxycortisone 0
                                          21-dehydrocortisone 0
                                          3alpha,21-dihydroxy-D-homo-5beta-pregn-17a(20)-en-11-one 0
                                          4,5-dihydrocortisone + 0
                                          6alpha-hydroxyprednisone 0
                                          6beta-hydroxycortisone 0
                                          6beta-hydroxyprednisone 0
                                          9-fluoro-2alpha-methylpregn-4-ene-3,11,20-trione 0
                                          Aphidicolin A3 0
                                          Asperfloroid 0
                                          Asperflosterol 0
                                          Cucurbitacin S 0
                                          Delta(6)-prednisone 0
                                          Emesterone A 0
                                          Emesterone B 0
                                          Ganodernoid C 0
                                          Ganoluciduone A 0
                                          Lucidenic acid O 0
                                          Mer-NF8054X 0
                                          Ochrasperfloroid 0
                                          RU 5135 1
                                          adrenosterone 1
                                          cortancyl 0
                                          cortisone + 25
                                          ganolucidic acid D 0
                                          methyl 20(21)-dehydrolucidenate A 0
                                          prednisone + 62
                                          zhankuic acid A + 0
                                          zhankuic acid A methyl ester 0
                                          zhankuic acid B 0
                                          zhankuic acid C 0
paths to the root