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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:licofelone
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Accession:CHEBI:47532 term browser browse the term
Definition:A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine substituted by methyl, methyl, carboxymethyl, 4-chlorophenyl, and phenyl groups at positions 2, 2, 5, 6, and 7, respectively. It is a dual inhibitor of cyclooxygenase isoforms and 5-lipoxygenase and is under development for treatment of osteoarthritis.
Synonyms:related_synonym: 6-(4-chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl-1H-pyrrolizine-5-acetic acid;   Formula=C23H22ClNO2;   InChI=1S/C23H22ClNO2/c1-23(2)13-19-22(15-6-4-3-5-7-15)21(16-8-10-17(24)11-9-16)18(12-20(26)27)25(19)14-23/h3-11H,12-14H2,1-2H3,(H,26,27);   InChIKey=UAWXGRJVZSAUSZ-UHFFFAOYSA-N;   ML 3000;   ML3000;   SMILES=CC1(C)CN2C(CC(O)=O)=C(C(=C2C1)C1=CC=CC=C1)C1=CC=C(Cl)C=C1;   [2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl]acetic acid;   licofelona;   licofelonum
 xref: CAS:156897-06-2;   DrugBank:DB04725;   HMDB:HMDB0254080
 xref_mesh: MESH:C088092
 xref: PDBeChem:LCF;   PMID:11671883;   PMID:12099169;   PMID:12136904;   PMID:15028114;   PMID:16448396;   PMID:17695530;   PMID:18268076;   PMID:18550688;   PMID:21681808;   PMID:21885812;   PMID:29163396;   PMID:29789101;   PMID:29891506;   PMID:30709010;   PMID:31471100;   PMID:31562745;   PMID:32949599;   PMID:33852076;   PMID:34395219;   PMID:34517113;   PMID:35923080;   PMID:37233919;   PMID:38173598;   PMID:39062118;   PMID:39395583;   PMID:9514627;   Patent:CZ20080621;   Wikipedia:Licofelone


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licofelone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il6 interleukin 6 increases expression ISO licofelone results in increased expression of IL6 mRNA CTD PMID:17766677 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
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  CHEBI ontology 19867
    role 19837
      biological role 19835
        pharmacological role 19069
          analgesic 14772
            licofelone 1
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Term Annotations click to browse term
  CHEBI ontology 19867
    subatomic particle 19865
      composite particle 19865
        hadron 19865
          baryon 19865
            nucleon 19865
              atomic nucleus 19865
                atom 19865
                  main group element atom 19803
                    p-block element atom 19803
                      carbon group element atom 19744
                        carbon atom 19740
                          organic molecular entity 19740
                            organic molecule 19692
                              organic cyclic compound 19482
                                carbocyclic compound 18587
                                  benzenoid aromatic compound 18009
                                    benzenes 17877
                                      chlorobenzenes 15047
                                        monochlorobenzenes 12149
                                          licofelone 1
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