|
G |
A2m |
alpha-2-macroglobulin |
decreases expression |
EXP |
Ketoconazole results in decreased expression of A2M mRNA |
CTD |
PMID:18289764 |
|
NCBI chr 4:154,897,770...154,947,787
|
|
G |
Aadat |
aminoadipate aminotransferase |
affects expression |
EXP |
Ketoconazole affects the expression of AADAT mRNA |
CTD |
PMID:18355885 |
|
NCBI chr16:29,509,392...29,544,332
|
|
G |
Aamp |
angio-associated, migratory cell protein |
increases expression |
ISO |
Ketoconazole results in increased expression of AAMP mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 9:75,863,382...75,869,188
|
|
G |
Aatf |
apoptosis antagonizing transcription factor |
decreases expression |
EXP |
Ketoconazole results in decreased expression of AATF mRNA |
CTD |
PMID:25787151 |
|
NCBI chr10:69,299,029...69,392,207
|
|
G |
Abat |
4-aminobutyrate aminotransferase |
increases expression |
EXP |
Ketoconazole results in increased expression of ABAT mRNA |
CTD |
PMID:37077353 |
|
NCBI chr10:7,503,351...7,599,474
|
|
G |
Abca1 |
ATP binding cassette subfamily A member 1 |
multiple interactions decreases expression |
EXP |
Ketoconazole inhibits the reaction [Clofibrate results in increased expression of ABCA1 mRNA] Ketoconazole results in decreased expression of ABCA1 mRNA |
CTD |
PMID:14690017 PMID:37077353 |
|
NCBI chr 5:72,473,676...72,596,563
|
|
G |
Abca3 |
ATP binding cassette subfamily A member 3 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of ABCA3 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr10:13,886,948...13,944,286
|
|
G |
Abcb11 |
ATP binding cassette subfamily B member 11 |
multiple interactions decreases activity |
ISO |
[Ketoconazole results in decreased activity of ABCB11 protein] which results in decreased export of Taurodeoxycholic Acid; Ketoconazole inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid] |
CTD |
PMID:20147439 PMID:20829430 PMID:23956101 PMID:24014644 PMID:28437613 |
|
NCBI chr 3:74,424,620...74,520,646
|
|
G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
increases transport multiple interactions decreases activity decreases expression affects expression |
ISO EXP |
ABCB1 protein results in increased transport of Ketoconazole [Ketoconazole binds to and results in decreased activity of ABCB1 protein] which results in decreased export of Digoxin; [Ketoconazole results in decreased activity of ABCB1 protein] which results in increased uptake of Digoxin; Ketoconazole binds to and results in decreased activity of ABCB1 protein; Ketoconazole inhibits the reaction [3,3'-diindolylmethane results in increased expression of ABCB1 mRNA]; Ketoconazole inhibits the reaction [ABCB1 protein affects the transport of Digoxin]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased chemical synthesis of globotriaosylceramide]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased chemical synthesis of Glucosylceramides]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased chemical synthesis of Lactosylceramides]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Ketoconazole inhibits the reaction [Doxorubicin results in increased expression of ABCB1 mRNA]; Ketoconazole inhibits the reaction [Ethanol results in increased expression of ABCB1 mRNA]; Ketoconazole inhibits the reaction [Hydrogen Peroxide affects the expression of ABCB1 mRNA]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [piperine results in increased expression of ABCB1 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [piperine results in increased expression of ABCB1 protein]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of ABCB1 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of ABCB1 protein]]; Ketoconazole inhibits the reaction [Paclitaxel results in increased expression of ABCB1 mRNA]; Ketoconazole inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]; Ketoconazole inhibits the reaction [Rifampin results in increased expression of ABCB1 mRNA]; Ketoconazole inhibits the reaction [Rifampin results in increased expression of ABCB1 protein]; Ketoconazole inhibits the reaction [Spironolactone results in increased expression of ABCB1 protein]; Ketoconazole inhibits the reaction [titanium dioxide results in increased expression of ABCB1 mRNA] Ketoconazole results in decreased expression of ABCB1 mRNA Ketoconazole inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]; Ketoconazole inhibits the reaction [Pregnenolone Carbonitrile results in increased expression of ABCB1 mRNA]; Ketoconazole inhibits the reaction [Pregnenolone Carbonitrile results in increased expression of ABCB1 protein] Ketoconazole affects the expression of ABCB1 mRNA Ketoconazole inhibits the reaction [Genistein results in increased expression of ABCB1A mRNA] Ketoconazole results in decreased expression of ABCB1A mRNA |
CTD |
PMID:10350002 PMID:12235267 PMID:14662772 PMID:15969931 PMID:16819505 PMID:17365992 PMID:18355885 PMID:19070657 PMID:20624464 PMID:21459122 PMID:23707768 PMID:23976943 PMID:25542144 PMID:25844889 PMID:32185415 PMID:33766574 PMID:35478211 PMID:36653537 PMID:36893891 More...
|
|
NCBI chr 4:26,312,403...26,488,456
|
|
G |
Abcb4 |
ATP binding cassette subfamily B member 4 |
decreases activity multiple interactions |
ISO EXP |
Ketoconazole results in decreased activity of ABCB4 protein [Chenodeoxycholic Acid co-treated with Ketoconazole] results in increased expression of ABCB4 mRNA |
CTD |
PMID:28437613 PMID:30985903 |
|
NCBI chr 4:26,106,895...26,164,440
|
|
G |
Abcc1 |
ATP binding cassette subfamily C member 1 |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [titanium dioxide results in increased expression of ABCC1 mRNA] |
CTD |
PMID:33766574 |
|
NCBI chr10:1,022,041...1,162,431
|
|
G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
decreases activity multiple interactions |
ISO EXP |
Ketoconazole results in decreased activity of ABCC2 protein Ketoconazole inhibits the reaction [Spironolactone results in increased expression of ABCC2 mRNA] |
CTD |
PMID:19070657 PMID:19766108 |
|
NCBI chr 1:252,613,875...252,672,459
|
|
G |
Abcd2 |
ATP binding cassette subfamily D member 2 |
increases expression |
EXP |
Ketoconazole results in increased expression of ABCD2 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr 7:122,263,034...122,311,642
|
|
G |
Abcg2 |
ATP binding cassette subfamily G member 2 |
multiple interactions increases expression |
EXP |
Ketoconazole inhibits the reaction [Genistein results in increased expression of ABCG2 mRNA] Ketoconazole results in increased expression of ABCG2 mRNA |
CTD |
PMID:32185415 PMID:37077353 |
|
NCBI chr 4:89,006,056...89,132,915
|
|
G |
Abracl |
ABRA C-terminal like |
decreases expression |
ISO |
Ketoconazole results in decreased expression of ABRACL mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 1:12,654,951...12,665,143
|
|
G |
Acaa1a |
acetyl-CoA acyltransferase 1A |
increases expression |
EXP |
Ketoconazole results in increased expression of ACAA1 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 8:127,956,126...127,966,348
|
|
G |
Acaa2 |
acetyl-CoA acyltransferase 2 |
increases expression |
EXP |
Ketoconazole results in increased expression of ACAA2 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr18:68,345,136...68,373,246
|
|
G |
Acadl |
acyl-CoA dehydrogenase, long chain |
increases expression |
EXP |
Ketoconazole results in increased expression of ACADL mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 9:68,333,981...68,372,149
|
|
G |
Acadm |
acyl-CoA dehydrogenase medium chain |
increases expression |
EXP |
Ketoconazole results in increased expression of ACADM mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 2:245,518,693...245,542,864
|
|
G |
Acads |
acyl-CoA dehydrogenase short chain |
increases expression |
EXP |
Ketoconazole results in increased expression of ACADS mRNA |
CTD |
PMID:37077353 |
|
NCBI chr12:41,493,650...41,502,897
|
|
G |
Ace2 |
angiotensin converting enzyme 2 |
increases expression |
ISO |
Ketoconazole results in increased expression of ACE2 mRNA |
CTD |
PMID:32808185 |
|
NCBI chr X:30,293,597...30,340,961
|
|
G |
Acot8 |
acyl-CoA thioesterase 8 |
increases expression |
EXP |
Ketoconazole results in increased expression of ACOT8 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 3:153,531,192...153,542,851
|
|
G |
Acsl4 |
acyl-CoA synthetase long-chain family member 4 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of ACSL4 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr X:110,739,633...110,803,416
|
|
G |
Acsl5 |
acyl-CoA synthetase long-chain family member 5 |
increases expression |
EXP |
Ketoconazole results in increased expression of ACSL5 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 1:254,289,513...254,336,608
|
|
G |
Acsm1 |
acyl-CoA synthetase medium-chain family member 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of ACSM1 mRNA |
CTD |
PMID:28263823 |
|
NCBI chr 1:173,985,715...174,020,565
|
|
G |
Adam9 |
ADAM metallopeptidase domain 9 |
affects expression |
EXP |
Ketoconazole affects the expression of ADAM9 mRNA |
CTD |
PMID:25787151 |
|
NCBI chr16:73,725,186...73,804,284
|
|
G |
Adcy6 |
adenylate cyclase 6 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of ADCY6 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 7:131,621,860...131,642,923
|
|
G |
Adh1c |
alcohol dehydrogenase 1C (class I), gamma polypeptide |
decreases expression |
EXP |
Ketoconazole results in decreased expression of ADH1 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr 2:226,797,303...226,808,892
|
|
G |
Adi1 |
acireductone dioxygenase 1 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of ADI1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 6:45,306,885...45,313,847
|
|
G |
Adipoq |
adiponectin, C1Q and collagen domain containing |
increases expression |
EXP |
Ketoconazole results in increased expression of ADIPOQ mRNA |
CTD |
PMID:36653537 |
|
NCBI chr11:91,226,524...91,240,244
|
|
G |
Adipor2 |
adiponectin receptor 2 |
increases expression |
EXP |
Ketoconazole results in increased expression of ADIPOR2 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 4:152,524,604...152,588,848
|
|
G |
Adora1 |
adenosine A1 receptor |
increases expression |
EXP |
Ketoconazole results in increased expression of ADORA1 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr13:45,658,872...45,695,821
|
|
G |
Adrb2 |
adrenoceptor beta 2 |
increases expression |
EXP |
Ketoconazole results in increased expression of ADRB2 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr18:57,912,760...57,914,802
|
|
G |
Aebp2 |
AE binding protein 2 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of AEBP2 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 4:173,527,881...173,566,033
|
|
G |
Agps |
alkylglycerone phosphate synthase |
increases expression |
ISO |
Ketoconazole results in increased expression of AGPS mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 3:60,747,323...60,845,831
|
|
G |
Agrp |
agouti related neuropeptide |
decreases expression |
EXP |
Ketoconazole results in decreased expression of AGRP mRNA |
CTD |
PMID:37077353 |
|
NCBI chr19:33,447,992...33,481,602
|
|
G |
Agt |
angiotensinogen |
increases expression |
EXP |
Ketoconazole results in increased expression of AGT mRNA |
CTD |
PMID:37077353 |
|
NCBI chr19:69,426,540...69,447,017
|
|
G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions increases activity increases expression |
ISO EXP |
AHR promotes the reaction [Ketoconazole results in increased expression of NQO1 mRNA]; AHR promotes the reaction [Ketoconazole results in increased expression of NQO1 protein]; Ketoconazole inhibits the reaction [Phenobarbital results in increased expression of AHR protein] Ketoconazole inhibits the reaction [Phenobarbital results in increased expression of AHR mRNA]; Ketoconazole inhibits the reaction [Phenobarbital results in increased expression of AHR protein]; Ketoconazole inhibits the reaction [Phenytoin results in increased expression of AHR protein] [Ketoconazole results in increased activity of AHR protein] which results in increased activity of and results in increased localization of NFE2L2 protein; [Ketoconazole results in increased activity of and results in increased localization of AHR protein] which results in increased expression of CYP1A1 mRNA; [Ketoconazole results in increased activity of and results in increased localization of AHR protein] which results in increased expression of CYP1A1 protein; AHR protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]]; AHR protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]]; Ketoconazole results in increased activity of and results in increased localization of AHR protein Ketoconazole results in increased expression of AHR mRNA |
CTD |
PMID:17505019 PMID:17923278 PMID:21753779 PMID:25000292 PMID:31168027 |
|
NCBI chr 6:57,961,423...57,998,901
|
|
G |
Ahrr |
aryl-hydrocarbon receptor repressor |
multiple interactions increases expression |
EXP |
[Ketoconazole co-treated with Carbon Tetrachloride] results in increased expression of AHRR mRNA Ketoconazole results in increased expression of AHRR mRNA |
CTD |
PMID:31168027 |
|
NCBI chr 1:28,993,634...29,088,673
|
|
G |
Ahsg |
alpha-2-HS-glycoprotein |
increases expression |
EXP |
Ketoconazole results in increased expression of AHSG mRNA |
CTD |
PMID:36653537 |
|
NCBI chr11:78,121,388...78,127,998
|
|
G |
Akap12 |
A-kinase anchoring protein 12 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of AKAP12 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 1:40,730,123...40,819,863
|
|
G |
Akr1b7 |
aldo-keto reductase family 1, member B7 |
increases expression |
EXP |
Ketoconazole results in increased expression of AKR1B7 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr 4:64,043,901...64,083,751
|
|
G |
Akr1c15 |
aldo-keto reductase family 1, member C15 |
increases expression |
EXP |
Ketoconazole results in increased expression of AKR1C15 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr17:66,181,493...66,208,090
|
|
G |
Alas1 |
5'-aminolevulinate synthase 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of ALAS1 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr 8:106,876,514...106,889,917
|
|
G |
Alb |
albumin |
affects expression |
EXP |
Ketoconazole affects the expression of ALB mRNA |
CTD |
PMID:36653537 |
|
NCBI chr14:17,891,564...17,907,043
|
|
G |
Aldh1a1 |
aldehyde dehydrogenase 1 family, member A1 |
affects expression |
EXP |
Ketoconazole affects the expression of ALDH1A1 mRNA |
CTD |
PMID:18355885 |
|
NCBI chr 1:218,000,470...218,152,962
|
|
G |
Aldh7a1 |
aldehyde dehydrogenase 7 family, member A1 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of ALDH7A1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr18:50,003,242...50,042,193
|
|
G |
Alkbh7 |
alkB homolog 7 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of ALKBH7 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr 9:1,838,886...1,841,044
|
|
G |
Alpl |
alkaline phosphatase, biomineralization associated |
multiple interactions increases expression |
ISO |
Ketoconazole inhibits the reaction [Calcifediol results in increased expression of ALPL mRNA] Ketoconazole results in increased expression of ALPL protein |
CTD |
PMID:21542014 PMID:31099283 |
|
NCBI chr 5:155,234,770...155,289,785
|
|
G |
Amdhd1 |
amidohydrolase domain containing 1 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of AMDHD1 mRNA |
CTD |
PMID:31099283 |
|
NCBI chr 7:28,043,923...28,059,156
|
|
G |
Amh |
anti-Mullerian hormone |
increases expression |
ISO |
Ketoconazole results in increased expression of AMH protein |
CTD |
PMID:16684832 |
|
NCBI chr 7:9,557,451...9,559,867
|
|
G |
Ang |
angiogenin |
increases expression |
ISO |
Ketoconazole results in increased expression of ANG mRNA |
CTD |
PMID:36621641 |
|
NCBI chr15:24,312,711...24,323,361
|
|
G |
Anxa1 |
annexin A1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of ANXA1 mRNA |
CTD |
PMID:25787151 |
|
NCBI chr 1:227,287,713...227,306,739
|
|
G |
Aox1 |
aldehyde oxidase 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of AOX1 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr 9:67,073,831...67,152,980
|
|
G |
Ap1s1 |
adaptor related protein complex 1 subunit sigma 1 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of AP1S1 mRNA |
CTD |
PMID:17175557 |
|
NCBI chr12:19,625,267...19,635,792
|
|
G |
Ap3m1 |
adaptor related protein complex 3 subunit mu 1 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of AP3M1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr15:3,246,616...3,264,846
|
|
G |
Apaf1 |
apoptotic peptidase activating factor 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of APAF1 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 7:27,381,392...27,466,772
|
|
G |
Apoa1 |
apolipoprotein A1 |
increases expression |
EXP |
Ketoconazole results in increased expression of APOA1 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr 8:55,423,945...55,425,729
|
|
G |
Apoa4 |
apolipoprotein A4 |
affects expression |
EXP |
Ketoconazole affects the expression of APOA4 mRNA |
CTD |
PMID:18355885 |
|
NCBI chr 8:55,435,779...55,438,160
|
|
G |
Apoe |
apolipoprotein E |
increases expression |
EXP |
Ketoconazole results in increased expression of APOE mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 1:88,481,889...88,485,816
|
|
G |
Ar |
androgen receptor |
multiple interactions decreases activity increases activity decreases expression |
ISO EXP |
[Goserelin co-treated with Dutasteride co-treated with bicalutamide co-treated with Ketoconazole] results in decreased expression of AR protein; Ketoconazole inhibits the reaction [Metribolone results in increased activity of AR protein]; Ketoconazole inhibits the reaction [Stanozolol binds to and results in increased activity of AR protein] Ketoconazole results in decreased activity of AR protein Ketoconazole results in increased activity of AR protein Ketoconazole results in decreased expression of AR protein Ketoconazole inhibits the reaction [Phenytoin results in increased expression of AR protein] |
CTD |
PMID:11118046 PMID:18324785 PMID:19226368 PMID:19587329 PMID:24323034 PMID:26867867 PMID:29162470 More...
|
|
NCBI chr X:63,104,771...63,273,934
|
|
G |
Arg1 |
arginase 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of ARG1 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 1:22,295,093...22,307,720
|
|
G |
Asb17 |
ankyrin repeat and SOCS box-containing 17 |
increases expression |
ISO |
Ketoconazole results in increased expression of ASB17 mRNA |
CTD |
PMID:31099283 |
|
NCBI chr 2:242,775,887...242,786,950
|
|
G |
Asns |
asparagine synthetase (glutamine-hydrolyzing) |
increases expression |
ISO |
Ketoconazole results in increased expression of ASNS mRNA |
CTD |
PMID:15342952 PMID:17175557 |
|
NCBI chr 4:36,752,061...36,769,970
|
|
G |
Ass1 |
argininosuccinate synthase 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of ASS1 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr 3:14,747,355...14,796,909
|
|
G |
Atad2 |
ATPase family, AAA domain containing 2 |
increases expression |
ISO |
Ketoconazole results in increased expression of ATAD2 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 7:91,523,626...91,566,238
|
|
G |
Atf1 |
activating transcription factor 1 |
multiple interactions |
ISO |
Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [Dinoprostone results in increased phosphorylation of ATF1 protein]]; Ketoconazole inhibits the reaction [Dinoprostone promotes the reaction [ATF1 protein modified form binds to PTGS2 promoter]]; Ketoconazole inhibits the reaction [Dinoprostone results in increased phosphorylation of ATF1 protein] |
CTD |
PMID:12164941 |
|
NCBI chr 7:131,361,962...131,404,677
|
|
G |
Atp5mc2 |
ATP synthase membrane subunit c locus 2 |
increases expression |
ISO |
Ketoconazole results in increased expression of ATP5MC2 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 7:133,791,341...133,799,713
|
|
G |
Atp5po |
ATP synthase peripheral stalk subunit OSCP |
increases expression |
EXP |
Ketoconazole results in increased expression of ATP5PO mRNA |
CTD |
PMID:37077353 |
|
NCBI chr11:44,651,171...44,657,483
|
|
G |
Atp6v1d |
ATPase H+ transporting V1 subunit D |
increases expression |
EXP |
Ketoconazole results in increased expression of ATP6V1D mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 6:97,656,725...97,672,295
|
|
G |
Avp |
arginine vasopressin |
increases expression |
EXP |
Ketoconazole results in increased expression of AVP mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 3:138,246,544...138,248,522
|
|
G |
Bace1 |
beta-secretase 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of BACE1 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 8:55,038,842...55,061,138
|
|
G |
Bad |
BCL2-associated agonist of cell death |
increases expression |
EXP |
Ketoconazole results in increased expression of BAD mRNA |
CTD |
PMID:25787151 |
|
NCBI chr 1:213,562,719...213,572,034
|
|
G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
ISO |
[Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in increased expression of BAX protein; Ketoconazole inhibits the reaction [Calcifediol results in decreased expression of BAX mRNA] |
CTD |
PMID:21542014 PMID:31629065 |
|
NCBI chr 1:105,076,472...105,081,906
|
|
G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
ISO |
[Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of BCL2 protein; Ketoconazole inhibits the reaction [Calcifediol results in increased expression of BCL2 mRNA] |
CTD |
PMID:21542014 PMID:31629065 |
|
NCBI chr13:23,204,464...23,366,900
|
|
G |
Bcl2l11 |
Bcl2-like 11 |
increases expression |
ISO |
Ketoconazole results in increased expression of BCL2L11 mRNA |
CTD |
PMID:25808816 |
|
NCBI chr 3:135,820,042...135,857,330
|
|
G |
Becn1 |
beclin 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of BECN1 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr10:86,731,649...86,747,002
|
|
G |
Bhmt |
betaine-homocysteine S-methyltransferase |
affects expression |
EXP |
Ketoconazole affects the expression of BHMT mRNA |
CTD |
PMID:18355885 |
|
NCBI chr 2:26,594,852...26,614,429
|
|
G |
Bicc1 |
BicC family RNA binding protein 1 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of BICC1 mRNA |
CTD |
PMID:31099283 |
|
NCBI chr20:17,449,639...17,686,775
|
|
G |
Bid |
BH3 interacting domain death agonist |
increases expression |
ISO |
Ketoconazole results in increased expression of BID mRNA |
CTD |
PMID:25808816 |
|
NCBI chr 4:155,785,366...155,808,775
|
|
G |
Bin1 |
bridging integrator 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of BIN1 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr18:24,009,731...24,067,267
|
|
G |
Birc5 |
baculoviral IAP repeat-containing 5 |
increases expression |
EXP |
Ketoconazole results in increased expression of BIRC5 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr10:103,567,369...103,580,069
|
|
G |
Bmp2 |
bone morphogenetic protein 2 |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [menatetrenone promotes the reaction [Phosphates results in increased expression of BMP2 mRNA]]; Ketoconazole inhibits the reaction [Phosphates promotes the reaction [menatetrenone results in increased expression of BMP2 mRNA]] |
CTD |
PMID:31843813 |
|
NCBI chr 3:141,264,648...141,275,416
|
|
G |
Bmp4 |
bone morphogenetic protein 4 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of BMP4 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr15:22,098,191...22,113,145
|
|
G |
Bmp6 |
bone morphogenetic protein 6 |
increases expression |
ISO |
Ketoconazole results in increased expression of BMP6 mRNA |
CTD |
PMID:32816093 |
|
NCBI chr17:26,523,704...26,785,558
|
|
G |
Bnc1 |
basonuclin zinc finger protein 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of BNC1 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr 1:135,917,676...135,943,333
|
|
G |
Bnip1 |
BCL2 interacting protein 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of BNIP1 mRNA |
CTD |
PMID:25808816 |
|
NCBI chr10:16,386,876...16,399,124
|
|
G |
Bnip2 |
BCL2 interacting protein 2 |
increases expression |
EXP |
Ketoconazole results in increased expression of BNIP2 mRNA |
CTD |
PMID:25808816 |
|
NCBI chr 8:70,640,436...70,661,782
|
|
G |
Bnip3 |
BCL2 interacting protein 3 |
increases expression |
EXP |
Ketoconazole results in increased expression of BNIP3 mRNA |
CTD |
PMID:25808816 |
|
NCBI chr 1:203,137,778...203,154,962
|
|
G |
Bnip3l |
BCL2 interacting protein 3 like |
decreases expression |
ISO |
Ketoconazole results in decreased expression of BNIP3L mRNA |
CTD |
PMID:36621641 |
|
NCBI chr15:45,350,081...45,373,213
|
|
G |
C10h5orf15 |
similar to human chromosome 5 open reading frame 15 |
increases expression |
ISO |
Ketoconazole results in increased expression of C5ORF15 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr10:37,064,889...37,077,493
|
|
G |
C1galt1 |
core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of C1GALT1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 4:36,894,440...36,932,434
|
|
G |
C1galt1c1 |
C1GALT1-specific chaperone 1 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of C1GALT1C1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr X:117,378,123...117,382,620
|
|
G |
C3 |
complement C3 |
increases expression |
EXP |
Ketoconazole results in increased expression of C3 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 9:2,174,412...2,201,339
|
|
G |
C5h1orf174 |
similar to human chromosome 1 open reading frame 174 |
increases expression |
ISO |
Ketoconazole results in increased expression of C1ORF174 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 5:164,515,578...164,520,022
|
|
G |
Cacna1h |
calcium voltage-gated channel subunit alpha1 H |
decreases expression |
EXP |
Ketoconazole results in decreased expression of CACNA1H mRNA |
CTD |
PMID:37077353 |
|
NCBI chr10:14,894,630...14,952,317
|
|
G |
Cacna1i |
calcium voltage-gated channel subunit alpha1 I |
decreases expression |
EXP |
Ketoconazole results in decreased expression of CACNA1I mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 7:113,716,266...113,827,670
|
|
G |
Cacna2d3 |
calcium voltage-gated channel auxiliary subunit alpha2delta 3 |
increases expression |
EXP |
Ketoconazole results in increased expression of CACNA2D3 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr16:4,098,439...4,912,498
|
|
G |
Cacna2d4 |
calcium voltage-gated channel auxiliary subunit alpha2delta 4 |
increases expression |
EXP |
Ketoconazole results in increased expression of CACNA2D4 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 4:152,408,588...152,521,478
|
|
G |
Cacnb1 |
calcium voltage-gated channel auxiliary subunit beta 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of CACNB1 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr10:82,998,182...83,018,838
|
|
G |
Cacng3 |
calcium voltage-gated channel auxiliary subunit gamma 3 |
increases expression |
EXP |
Ketoconazole results in increased expression of CACNG3 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 1:177,201,361...177,297,019
|
|
G |
Cacng4 |
calcium voltage-gated channel auxiliary subunit gamma 4 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of CACNG4 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr10:92,683,778...92,745,842
|
|
G |
Calb1 |
calbindin 1 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of CALB1 mRNA |
CTD |
PMID:31099283 |
|
NCBI chr 5:29,375,624...29,402,532
|
|
G |
Calb2 |
calbindin 2 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of CALB2 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr19:38,114,435...38,141,438
|
|
G |
Cap1 |
cyclase associated actin cytoskeleton regulatory protein 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of CAP1 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr 5:135,142,108...135,168,885
|
|
G |
Car2 |
carbonic anhydrase 2 |
increases expression |
EXP |
Ketoconazole results in increased expression of CA2 mRNA; Ketoconazole results in increased expression of CAR2 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 2:88,462,883...88,478,012
|
|
G |
Carmil1 |
capping protein regulator and myosin 1 linker 1 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of CARMIL1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr17:40,807,921...41,088,326
|
|
G |
Casp12 |
caspase 12 |
increases expression |
ISO |
Ketoconazole results in increased expression of CASP12 mRNA |
CTD |
PMID:25808816 |
|
NCBI chr 8:10,927,188...10,954,442
|
|
G |
Casp3 |
caspase 3 |
increases activity multiple interactions |
ISO |
Ketoconazole results in increased activity of CASP3 protein Ketoconazole inhibits the reaction [Galactosamine results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [Ketoconazole results in increased activity of CASP3 protein] |
CTD |
PMID:17936189 PMID:19631732 |
|
NCBI chr16:52,395,539...52,413,794
|
|
G |
Casp6 |
caspase 6 |
decreases expression increases expression |
EXP |
Ketoconazole results in decreased expression of CASP6 mRNA Ketoconazole results in increased expression of CASP6 mRNA |
CTD |
PMID:25787151 PMID:25808816 |
|
NCBI chr 2:221,140,287...221,152,727
|
|
G |
Casp7 |
caspase 7 |
increases expression |
EXP |
Ketoconazole results in increased expression of CASP7 mRNA |
CTD |
PMID:25808816 |
|
NCBI chr 1:265,442,647...265,481,938
|
|
G |
Casp8ap2 |
caspase 8 associated protein 2 |
affects expression |
ISO |
Ketoconazole affects the expression of CASP8AP2 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 5:51,809,366...51,848,633
|
|
G |
Casp9 |
caspase 9 |
increases expression |
ISO |
Ketoconazole results in increased expression of CASP9 mRNA |
CTD |
PMID:25808816 |
|
|
|
G |
Cat |
catalase |
decreases expression |
EXP |
Ketoconazole results in decreased expression of CAT mRNA |
CTD |
PMID:25787151 |
|
NCBI chr 3:110,297,340...110,329,526
|
|
G |
Cav1 |
caveolin 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of CAV1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 4:46,606,538...46,639,616
|
|
G |
Cbx7 |
chromobox 7 |
increases expression |
EXP |
Ketoconazole results in increased expression of CBX7 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 7:113,341,030...113,358,716
|
|
G |
Ccdc8 |
coiled-coil domain containing 8 |
increases expression |
EXP |
Ketoconazole results in increased expression of CCDC8 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr 1:86,807,607...86,810,935
|
|
G |
Cck |
cholecystokinin |
increases expression |
EXP |
Ketoconazole results in increased expression of CCK mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 8:121,153,499...121,160,194
|
|
G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions increases expression |
ISO EXP |
Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]; PTGER2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; PTGER3 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]] Ketoconazole results in increased expression of CCL2 mRNA |
CTD |
PMID:16784723 PMID:37077353 |
|
NCBI chr10:67,503,077...67,504,875
|
|
G |
Ccl27 |
C-C motif chemokine ligand 27 |
multiple interactions |
ISO |
Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 mRNA]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 mRNA]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]; PTGER2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; PTGER3 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]] |
CTD |
PMID:16784723 |
|
NCBI chr 5:56,941,402...56,948,511
|
|
G |
Ccl5 |
C-C motif chemokine ligand 5 |
multiple interactions increases expression |
ISO EXP |
Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]; PTGER2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]; PTGER3 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]] Ketoconazole results in increased expression of CCL5 mRNA |
CTD |
PMID:16784723 PMID:23688403 PMID:37077353 |
|
NCBI chr10:68,820,330...68,824,906
|
|
G |
Ccn1 |
cellular communication network factor 1 |
increases expression affects expression |
ISO EXP |
Ketoconazole results in increased expression of CCN1 mRNA Ketoconazole affects the expression of CCN1 mRNA |
CTD |
PMID:36621641 PMID:36653537 |
|
NCBI chr 2:234,562,410...234,565,370
|
|
G |
Ccng1 |
cyclin G1 |
increases expression |
EXP |
Ketoconazole results in increased expression of CCNG1 mRNA |
CTD |
PMID:18289764 |
|
NCBI chr10:25,678,503...25,684,876
|
|
G |
Cd200 |
Cd200 molecule |
increases expression |
ISO |
Ketoconazole results in increased expression of CD200 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr11:68,916,200...68,943,570
|
|
G |
Cd247 |
Cd247 molecule |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased abundance of Calcitriol]; Ketoconazole inhibits the reaction [Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]] |
CTD |
PMID:24792400 |
|
NCBI chr13:80,576,264...80,651,422
|
|
G |
Cd274 |
CD274 molecule |
decreases expression |
EXP |
Ketoconazole results in decreased expression of CD274 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 1:236,526,215...236,549,956
|
|
G |
Cd28 |
Cd28 molecule |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased abundance of Calcitriol]; Ketoconazole inhibits the reaction [Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]] |
CTD |
PMID:24792400 |
|
NCBI chr 9:69,660,316...69,689,192
|
|
G |
Cd3d |
CD3 delta subunit of T-cell receptor complex |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased abundance of Calcitriol]; Ketoconazole inhibits the reaction [Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]] |
CTD |
PMID:24792400 |
|
NCBI chr 8:54,184,573...54,190,112
|
|
G |
Cd3e |
CD3 epsilon subunit of T-cell receptor complex |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased abundance of Calcitriol]; Ketoconazole inhibits the reaction [Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]] |
CTD |
PMID:24792400 |
|
NCBI chr 8:54,200,617...54,211,770
|
|
G |
Cd3g |
CD3 gamma subunit of T-cell receptor complex |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased abundance of Calcitriol]; Ketoconazole inhibits the reaction [Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]] |
CTD |
PMID:24792400 |
|
NCBI chr 8:54,177,572...54,184,087
|
|
G |
Cd47 |
Cd47 molecule |
increases expression |
ISO |
Ketoconazole results in increased expression of CD47 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr11:64,374,816...64,438,763
|
|
G |
Cdc42ep2 |
CDC42 effector protein 2 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of CDC42EP2 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr 1:203,202,000...203,210,891
|
|
G |
Cdc42ep3 |
CDC42 effector protein 3 |
increases expression |
EXP |
Ketoconazole results in increased expression of CDC42EP3 mRNA |
CTD |
PMID:28263823 |
|
NCBI chr 6:21,463,081...21,483,553
|
|
G |
Cdk2 |
cyclin dependent kinase 2 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of CDK2 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 7:1,714,392...1,721,964
|
|
G |
Cdk6 |
cyclin-dependent kinase 6 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of CDK6 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 4:31,592,384...31,784,732
|
|
G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression |
ISO EXP |
Ketoconazole results in increased expression of CDKN1A mRNA |
CTD |
PMID:16483768 PMID:25808816 PMID:37077353 |
|
NCBI chr20:7,150,820...7,161,373
|
|
G |
Cdkn1b |
cyclin-dependent kinase inhibitor 1B |
increases expression |
EXP |
Ketoconazole results in increased expression of CDKN1B mRNA |
CTD |
PMID:25808816 |
|
NCBI chr 4:169,491,273...169,496,500
|
|
G |
Cdkn2c |
cyclin-dependent kinase inhibitor 2C |
affects expression |
EXP |
Ketoconazole affects the expression of CDKN2C mRNA |
CTD |
PMID:18355885 |
|
NCBI chr 5:129,639,736...129,645,564
|
|
G |
Cebpa |
CCAAT/enhancer binding protein alpha |
increases expression |
EXP |
Ketoconazole results in increased expression of CEBPA mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 1:87,759,631...87,762,303
|
|
G |
Cenpu |
centromere protein U |
decreases expression |
ISO |
Ketoconazole results in decreased expression of CENPU mRNA |
CTD |
PMID:36621641 |
|
NCBI chr16:52,448,446...52,471,662
|
|
G |
Cep15 |
centrosomal protein 15 |
increases expression |
ISO |
Ketoconazole results in increased expression of CEP15 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr15:12,815,159...12,835,115
|
|
G |
Cep19 |
centrosomal protein 19 |
increases expression |
ISO |
Ketoconazole results in increased expression of CEP19 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr11:68,677,869...68,687,117
|
|
G |
Ces2h |
carboxylesterase 2H |
affects expression |
EXP |
Ketoconazole affects the expression of CES2 mRNA |
CTD |
PMID:18355885 |
|
NCBI chr19:32,974,242...32,988,842
|
|
G |
Cfb |
complement factor B |
increases expression |
EXP |
Ketoconazole results in increased expression of CFB mRNA |
CTD |
PMID:36653537 |
|
NCBI chr20:3,970,643...3,976,510
|
|
G |
Cga |
glycoprotein hormones, alpha polypeptide |
decreases expression |
ISO |
Ketoconazole results in decreased expression of CGA mRNA |
CTD |
PMID:25808816 |
|
NCBI chr 5:54,283,109...54,295,464
|
|
G |
Chrac1 |
chromatin accessibility complex subunit 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of CHRAC1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 7:106,901,841...106,905,441
|
|
G |
Cibar1 |
CBY1 interacting BAR domain containing 1 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of CIBAR1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 5:25,613,993...25,632,440
|
|
G |
Cidea |
cell death-inducing DFFA-like effector a |
increases expression |
EXP |
Ketoconazole results in increased expression of CIDEA mRNA |
CTD |
PMID:36653537 PMID:37077353 |
|
NCBI chr18:63,164,817...63,190,384
|
|
G |
Ckap2l |
cytoskeleton associated protein 2-like |
decreases expression |
ISO |
Ketoconazole results in decreased expression of CKAP2L mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 3:116,497,186...116,524,302
|
|
G |
Clcf1 |
cardiotrophin-like cytokine factor 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of CLCF1 mRNA |
CTD |
PMID:31099283 |
|
NCBI chr 1:201,507,763...201,517,607
|
|
G |
Clec4e |
C-type lectin domain family 4, member E |
increases expression |
ISO |
Ketoconazole results in increased expression of CLEC4E mRNA |
CTD |
PMID:31099283 |
|
NCBI chr 4:158,292,624...158,298,607
|
|
G |
Clmn |
calmin |
multiple interactions |
ISO |
Ketoconazole promotes the reaction [Calcitriol results in increased expression of CLMN mRNA] |
CTD |
PMID:26485663 |
|
NCBI chr 6:123,707,710...123,807,283
|
|
G |
Cln5 |
CLN5, intracellular trafficking protein |
affects expression |
ISO |
Ketoconazole affects the expression of CLN5 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr15:79,893,573...79,903,438
|
|
G |
Clu |
clusterin |
affects expression decreases expression |
EXP |
Ketoconazole affects the expression of CLU mRNA Ketoconazole results in decreased expression of CLU mRNA |
CTD |
PMID:17558187 PMID:18289764 |
|
NCBI chr15:40,161,068...40,200,315
|
|
G |
Cmtm6 |
CKLF-like MARVEL transmembrane domain containing 6 |
affects expression |
EXP |
Ketoconazole affects the expression of CMTM6 mRNA |
CTD |
PMID:18355885 |
|
NCBI chr 8:114,422,934...114,441,034
|
|
G |
Cmtm7 |
CKLF-like MARVEL transmembrane domain containing 7 |
increases expression |
ISO |
Ketoconazole results in increased expression of CMTM7 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 8:114,448,037...114,474,958
|
|
G |
Cnr2 |
cannabinoid receptor 2 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of CNR2 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr 5:153,408,968...153,435,092
|
|
G |
Col1a1 |
collagen type I alpha 1 chain |
decreases expression |
EXP |
Ketoconazole results in decreased expression of COL1A1 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr10:80,380,458...80,397,461
|
|
G |
Commd2 |
COMM domain containing 2 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of COMMD2 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 2:141,848,661...141,852,907
|
|
G |
Cop1 |
COP1, E3 ubiquitin ligase |
decreases expression |
ISO |
Ketoconazole results in decreased expression of COP1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr13:73,954,058...74,095,283
|
|
G |
Copz1 |
COPI coat complex subunit zeta 1 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of COPZ1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 7:134,409,523...134,435,661
|
|
G |
Cox18 |
cytochrome c oxidase assembly factor COX18 |
affects expression |
ISO |
Ketoconazole affects the expression of COX18 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr14:18,147,558...18,161,622
|
|
G |
Cpn2 |
carboxypeptidase N subunit 2 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of CPN2 mRNA |
CTD |
PMID:31099283 |
|
NCBI chr11:70,486,054...70,495,937
|
|
G |
Cpped1 |
calcineurin-like phosphoesterase domain containing 1 |
affects expression |
EXP |
Ketoconazole affects the expression of CPPED1 mRNA |
CTD |
PMID:18355885 |
|
NCBI chr10:3,701,522...3,821,050
|
|
G |
Cpt1b |
carnitine palmitoyltransferase 1B |
decreases expression |
EXP |
Ketoconazole results in decreased expression of CPT1B mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 7:120,491,354...120,500,833
|
|
G |
Cpt2 |
carnitine palmitoyltransferase 2 |
increases expression |
EXP |
Ketoconazole results in increased expression of CPT2 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 5:122,664,677...122,682,126
|
|
G |
Cr2 |
complement C3d receptor 2 |
increases expression |
EXP |
Ketoconazole results in increased expression of CR2 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr13:109,207,034...109,244,980
|
|
G |
Creb1 |
cAMP responsive element binding protein 1 |
multiple interactions decreases expression |
ISO EXP |
Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [Dinoprostone results in increased phosphorylation of CREB1 protein]]; Ketoconazole inhibits the reaction [Dinoprostone promotes the reaction [CREB1 protein modified form binds to PTGS2 promoter]]; Ketoconazole inhibits the reaction [Dinoprostone results in increased phosphorylation of CREB1 protein] Ketoconazole inhibits the reaction [Arachidonic Acid results in increased phosphorylation of CREB1 protein]; Ketoconazole inhibits the reaction [Epinephrine results in increased phosphorylation of CREB1 protein] Ketoconazole results in decreased expression of CREB1 mRNA |
CTD |
PMID:12164941 PMID:17680988 PMID:37077353 |
|
NCBI chr 9:73,397,333...73,466,339
|
|
G |
Crem |
cAMP responsive element modulator |
affects expression decreases expression |
EXP |
Ketoconazole affects the expression of CREM mRNA Ketoconazole results in decreased expression of CREM mRNA |
CTD |
PMID:18355885 PMID:36653537 |
|
NCBI chr17:58,932,011...59,001,160
|
|
G |
Crhr2 |
corticotropin releasing hormone receptor 2 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of CRHR2 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 4:85,553,163...85,596,203
|
|
G |
Crls1 |
cardiolipin synthase 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of CRLS1 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr 3:140,572,680...140,591,543
|
|
G |
Crym |
crystallin, mu |
decreases expression |
EXP |
Ketoconazole results in decreased expression of CRYM mRNA |
CTD |
PMID:36653537 |
|
NCBI chr 1:174,560,423...174,575,660
|
|
G |
Ctnnb1 |
catenin beta 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of CTNNB1 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 8:129,517,576...129,544,661
|
|
G |
Ctsl |
cathepsin L |
decreases expression |
ISO |
Ketoconazole results in decreased expression of CTSL mRNA |
CTD |
PMID:36621641 |
|
NCBI chr17:770,104...776,266
|
|
G |
Ctss |
cathepsin S |
affects expression |
EXP |
Ketoconazole affects the expression of CTSS mRNA |
CTD |
PMID:18289764 |
|
NCBI chr 2:185,775,316...185,803,440
|
|
G |
Cxcl10 |
C-X-C motif chemokine ligand 10 |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [Biological Products results in increased expression of CXCL10 mRNA]; Ketoconazole inhibits the reaction [Biological Products results in increased expression of CXCL10 protein] |
CTD |
PMID:24471457 |
|
NCBI chr14:15,989,066...15,991,263
|
|
G |
Cxcl14 |
C-X-C motif chemokine ligand 14 |
increases expression |
EXP |
Ketoconazole results in increased expression of CXCL14 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr17:8,323,150...8,331,176
|
|
G |
Cyba |
cytochrome b-245 alpha chain |
increases expression |
EXP |
Ketoconazole results in increased expression of CYBA mRNA |
CTD |
PMID:37077353 |
|
NCBI chr19:50,487,598...50,495,669
|
|
G |
Cycs |
cytochrome c, somatic |
decreases expression increases expression |
EXP |
Ketoconazole results in decreased expression of CYCS mRNA Ketoconazole results in increased expression of CYCS mRNA |
CTD |
PMID:25787151 PMID:37077353 |
|
NCBI chr 4:80,982,667...80,984,767
|
|
G |
Cyct |
cytochrome c, testis |
increases expression |
EXP |
Ketoconazole results in increased expression of CYCT mRNA |
CTD |
PMID:25787151 |
|
NCBI chr 3:81,697,333...81,704,401
|
|
G |
Cyp11a1 |
cytochrome P450, family 11, subfamily a, polypeptide 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of CYP11A1 mRNA |
CTD |
PMID:26610754 |
|
NCBI chr 8:67,318,665...67,330,196
|
|
G |
Cyp11b2 |
cytochrome P450, family 11, subfamily b, polypeptide 2 |
multiple interactions decreases activity |
ISO |
Ketoconazole binds to and results in decreased activity of CYP11B1 protein Ketoconazole results in decreased activity of CYP11B1 protein |
CTD |
PMID:15743198 PMID:31982514 |
|
NCBI chr 7:108,719,349...108,726,024
|
|
G |
Cyp11b3 |
cytochrome P450, family 11, subfamily b, polypeptide 3 |
decreases activity increases expression multiple interactions |
ISO |
Ketoconazole results in decreased activity of CYP11B2 protein Ketoconazole results in increased expression of CYP11B2 mRNA Ketoconazole binds to and results in decreased activity of CYP11B2 protein; Ketoconazole promotes the reaction [Colforsin results in increased expression of CYP11B2 mRNA] |
CTD |
PMID:15743198 PMID:16935330 PMID:31982514 |
|
NCBI chr 7:106,808,559...106,814,048
|
|
G |
Cyp17a1 |
cytochrome P450, family 17, subfamily a, polypeptide 1 |
decreases activity multiple interactions decreases expression |
ISO EXP |
Ketoconazole results in decreased activity of CYP17A1 protein Ketoconazole inhibits the reaction [Colforsin results in increased expression of CYP17A1 mRNA] Ketoconazole results in decreased expression of CYP17A1 mRNA |
CTD |
PMID:11118046 PMID:15743198 PMID:15771425 PMID:15934942 PMID:16935330 PMID:25993309 PMID:31330226 PMID:31982514 PMID:36653537 More...
|
|
NCBI chr 1:245,535,462...245,543,148
|
|
G |
Cyp19a1 |
cytochrome P450, family 19, subfamily a, polypeptide 1 |
increases activity decreases activity multiple interactions decreases expression |
ISO EXP |
Ketoconazole results in increased activity of CYP19A1 protein Ketoconazole results in decreased activity of CYP19A1 protein [Ketoconazole results in increased activity of CYP19A1 protein] which results in increased chemical synthesis of Estrone; [Ketoconazole results in increased activity of CYP19A1 protein] which results in increased metabolism of Androstenedione Ketoconazole results in decreased expression of CYP19A1 mRNA |
CTD |
PMID:20087668 PMID:27159630 PMID:31330226 PMID:36374910 PMID:36653537 |
|
NCBI chr 8:63,449,148...63,476,534
|
|
G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases activity multiple interactions decreases activity increases expression |
ISO EXP |
Ketoconazole results in increased activity of CYP1A1 protein [Ketoconazole co-treated with Carbon Tetrachloride] results in increased expression of CYP1A1 mRNA; Ketoconazole inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] Ketoconazole results in decreased activity of CYP1A1 protein [Ketoconazole results in increased activity of and results in increased localization of AHR protein] which results in increased expression of CYP1A1 mRNA; [Ketoconazole results in increased activity of and results in increased localization of AHR protein] which results in increased expression of CYP1A1 protein; Dactinomycin inhibits the reaction [Ketoconazole results in increased expression of CYP1A1 mRNA]; Ketoconazole binds to and results in decreased activity of and results in increased expression of CYP1A1 protein; Ketoconazole inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; Ketoconazole results in increased expression of and results in increased activity of CYP1A1 protein Ketoconazole results in increased expression of CYP1A1 mRNA; Ketoconazole results in increased expression of CYP1A1 protein Ketoconazole binds to and results in decreased activity of and results in increased expression of CYP1A1 protein; Ketoconazole results in increased expression of and results in increased activity of CYP1A1 protein |
CTD |
PMID:14709627 PMID:17283379 PMID:18420780 PMID:18493746 PMID:19070657 PMID:21753779 PMID:25000292 PMID:26886340 PMID:31168027 PMID:34181028 More...
|
|
NCBI chr 8:66,991,940...66,998,014
|
|
G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
multiple interactions decreases activity increases expression |
ISO EXP |
Ketoconazole affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]; Ketoconazole inhibits the reaction [CYP1A2 protein results in increased metabolism of Triazines] Ketoconazole inhibits the reaction [CYP1A2 protein results in increased oxidation of Uroporphyrinogens] Ketoconazole inhibits the reaction [CYP1A2 protein results in increased metabolism of 3-cyano-7-ethoxycoumarin] Ketoconazole results in decreased activity of CYP1A2 protein Ketoconazole results in increased expression of CYP1A2 mRNA; Ketoconazole results in increased expression of CYP1A2 protein |
CTD |
PMID:1567206 PMID:9305587 PMID:12814958 PMID:15618748 PMID:15879494 PMID:15916432 PMID:18420780 PMID:19858067 PMID:24120545 PMID:25000292 More...
|
|
NCBI chr 8:66,971,261...66,978,149
|
|
G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
decreases activity |
ISO |
Ketoconazole results in decreased activity of CYP1B1 protein |
CTD |
PMID:14709627 PMID:18420780 |
|
NCBI chr 6:21,093,927...21,103,091
|
|
G |
Cyp24a1 |
cytochrome P450, family 24, subfamily a, polypeptide 1 |
multiple interactions decreases activity |
EXP ISO |
[Ketoconazole co-treated with Calcitriol] results in increased expression of CYP24A1 mRNA; Ketoconazole inhibits the reaction [Calcitriol results in increased activity of CYP24A1 protein] Ketoconazole results in decreased activity of CYP24A1 protein [Ketoconazole results in decreased metabolism of alfacalcidol] which results in decreased expression of CYP24A1 mRNA; [Ketoconazole results in decreased metabolism of Calcitriol] which results in increased expression of CYP24A1 mRNA; Ketoconazole promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA] Ketoconazole inhibits the reaction [Calcifediol results in increased expression of CYP24A1 mRNA]; Ketoconazole promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA] |
CTD |
PMID:16483768 PMID:16824767 PMID:18840526 PMID:20206692 PMID:26485663 |
|
NCBI chr 3:179,694,647...179,709,083
|
|
G |
Cyp26a1 |
cytochrome P450, family 26, subfamily a, polypeptide 1 |
decreases response to substance multiple interactions decreases activity increases expression |
ISO EXP |
Ketoconazole results in decreased susceptibility to CYP26A1 protein [[Ketoconazole results in decreased activity of CYP26A1 protein] which results in decreased metabolism of Tretinoin] which results in decreased chemical synthesis of 4-hydroxyretinoic acid; [[Ketoconazole results in decreased activity of CYP26A1 protein] which results in decreased metabolism of Tretinoin] which results in decreased chemical synthesis of 4-oxoretinoic acid; [Ketoconazole results in decreased activity of CYP26A1 protein] which results in decreased chemical synthesis of 4-hydroxyretinoic acid; [Ketoconazole results in decreased activity of CYP26A1 protein] which results in decreased chemical synthesis of 4-oxoretinoic acid; [Ketoconazole results in decreased activity of CYP26A1 protein] which results in decreased metabolism of Tretinoin; Ketoconazole inhibits the reaction [CYP26A1 mRNA results in increased chemical synthesis of 4-hydroxyretinoic acid]; Ketoconazole inhibits the reaction [CYP26A1 mRNA results in increased chemical synthesis of 4-oxoretinoic acid]; Ketoconazole inhibits the reaction [CYP26A1 mRNA results in increased metabolism of 4-oxoretinoic acid]; Ketoconazole inhibits the reaction [CYP26A1 mRNA results in increased metabolism of Tretinoin]; Ketoconazole inhibits the reaction [CYP26A1 protein inhibits the reaction [Tretinoin results in increased activity of FAS protein]]; Ketoconazole inhibits the reaction [CYP26A1 protein inhibits the reaction [Tretinoin results in increased activity of TNF protein]]; Ketoconazole inhibits the reaction [CYP26A1 protein inhibits the reaction [Tretinoin results in increased activity of TNFSF10 protein]]; Ketoconazole inhibits the reaction [CYP26A1 protein results in increased metabolism of and results in decreased susceptibility to Tretinoin]; Ketoconazole inhibits the reaction [CYP26A1 protein results in increased metabolism of Tretinoin]; Ketoconazole inhibits the reaction [CYP26A1 results in increased metabolism of Tretinoin] Ketoconazole results in decreased activity of CYP26A1; Ketoconazole results in decreased activity of CYP26A1 protein Ketoconazole results in increased expression of CYP26A1 mRNA |
CTD |
PMID:12091498 PMID:14532297 PMID:15703382 PMID:18059332 PMID:21906690 PMID:25492813 PMID:28263823 PMID:37077353 More...
|
|
NCBI chr 1:235,471,368...235,475,204
|
|
G |
Cyp26b1 |
cytochrome P450, family 26, subfamily b, polypeptide 1 |
multiple interactions decreases activity |
ISO |
Ketoconazole inhibits the reaction [CYP26B1 protein results in increased metabolism of Tretinoin]; Ketoconazole inhibits the reaction [CYP26B1 results in increased metabolism of Tretinoin] Ketoconazole results in decreased activity of CYP26B1 |
CTD |
PMID:14532297 PMID:21906690 |
|
NCBI chr 4:117,041,808...117,058,628
|
|
G |
Cyp26c1 |
cytochrome P450, family 26, subfamily C, polypeptide 1 |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [CYP26C1 protein results in increased metabolism of alitretinoin]; Ketoconazole inhibits the reaction [CYP26C1 protein results in increased metabolism of Tretinoin] |
CTD |
PMID:21906690 |
|
NCBI chr 1:235,458,961...235,468,433
|
|
G |
Cyp27b1 |
cytochrome P450, family 27, subfamily b, polypeptide 1 |
decreases activity |
EXP |
Ketoconazole results in decreased activity of CYP27B1 protein |
CTD |
PMID:16483768 |
|
NCBI chr 7:64,756,626...64,761,570
|
|
G |
Cyp2a1 |
cytochrome P450, family 2, subfamily a, polypeptide 1 |
affects expression increases expression decreases activity |
EXP |
Ketoconazole affects the expression of CYP2A1 mRNA Ketoconazole results in increased expression of CYP2A1 protein Ketoconazole results in decreased activity of CYP2A1 protein |
CTD |
PMID:7986207 PMID:15879494 PMID:18355885 |
|
NCBI chr 1:82,231,611...82,244,887
|
|
G |
Cyp2a2 |
cytochrome P450, family 2, subfamily a, polypeptide 2 |
multiple interactions |
EXP |
Ketoconazole inhibits the reaction [CYP2A2 protein results in increased metabolism of 7-benzyloxyquinoline] |
CTD |
PMID:19858067 |
|
NCBI chr 1:82,263,833...82,289,487
|
|
G |
Cyp2a3 |
cytochrome P450, family 2, subfamily a, polypeptide 3 |
decreases activity |
ISO |
Ketoconazole results in decreased activity of CYP2A4 protein |
CTD |
PMID:18420780 |
|
NCBI chr 1:91,299,584...91,307,650
|
|
G |
Cyp2b1 |
cytochrome P450, family 2, subfamily b, polypeptide 1 |
multiple interactions |
EXP |
Ketoconazole inhibits the reaction [CYP2B1 protein results in increased metabolism of 7-benzyloxy-4-trifluoromethylcoumarin] |
CTD |
PMID:19858067 |
|
NCBI chr 1:90,646,098...90,669,762
|
|
G |
Cyp2b15 |
cytochrome P450, family 2, subfamily b, polypeptide 15 |
affects expression |
EXP |
Ketoconazole affects the expression of CYP2B15 mRNA |
CTD |
PMID:18355885 |
|
NCBI chr 1:82,094,188...82,106,492
|
|
G |
Cyp2b3 |
cytochrome P450, family 2, subfamily b, polypeptide 3 |
decreases activity multiple interactions increases expression |
ISO |
Ketoconazole results in decreased activity of CYP2B6 protein Ketoconazole inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]; Ketoconazole inhibits the reaction [Phenobarbital results in increased expression of CYP2B6 mRNA]; Ketoconazole inhibits the reaction [Rifampin results in increased expression of CYP2B6 mRNA] Ketoconazole results in increased expression of CYP2B10 mRNA Ketoconazole results in decreased activity of CYP2B10 protein |
CTD |
PMID:14709627 PMID:16608920 PMID:17438109 PMID:17966066 PMID:18420780 |
|
NCBI chr 1:90,780,468...90,859,852
|
|
G |
Cyp2c11 |
cytochrome P450, subfamily 2, polypeptide 11 |
multiple interactions decreases activity |
EXP |
Ketoconazole inhibits the reaction [CYP2C11 protein results in increased metabolism of 7-methoxy-4-trifluoromethylcoumarin] Ketoconazole results in decreased activity of CYP2C11 protein |
CTD |
PMID:15879494 PMID:19858067 |
|
NCBI chr 1:246,175,216...246,211,445
|
|
G |
Cyp2c6 |
cytochrome P450, family 2, subfamily C, polypeptide 6 |
multiple interactions decreases activity |
EXP ISO |
Ketoconazole inhibits the reaction [CYP2C6 protein results in increased metabolism of 7-methoxy-4-trifluoromethylcoumarin] Ketoconazole results in decreased activity of CYP2C6 protein Ketoconazole results in decreased activity of CYP2C19 protein Ketoconazole affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] Ketoconazole results in decreased activity of CYP2C29 protein |
CTD |
PMID:12814958 PMID:14709627 PMID:15618748 PMID:15879494 PMID:18420780 PMID:19858067 PMID:24120545 More...
|
|
NCBI chr 1:247,879,058...247,916,804
|
|
G |
Cyp2c79 |
cytochrome P450, family 2, subfamily c, polypeptide 79 |
decreases activity multiple interactions |
ISO |
Ketoconazole results in decreased activity of CYP2C8 protein Ketoconazole affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] |
CTD |
PMID:14709627 PMID:15601807 PMID:24120545 |
|
|
|
G |
Cyp2d2 |
cytochrome P450, family 2, subfamily d, polypeptide 2 |
multiple interactions |
EXP |
Ketoconazole inhibits the reaction [CYP2D2 protein results in increased metabolism of 3-(2-(N,N-diethyl-N-methylammonium)ethyl)-7-methoxy-4-methylcoumarin] |
CTD |
PMID:19858067 |
|
NCBI chr 7:113,935,138...113,939,209
|
|
G |
Cyp2d4 |
cytochrome P450, family 2, subfamily d, polypeptide 4 |
multiple interactions decreases activity decreases expression |
ISO |
Ketoconazole affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]; Ketoconazole inhibits the reaction [CYP2D6 protein results in increased metabolism of YM 758] Ketoconazole results in decreased activity of CYP2D6 protein Ketoconazole inhibits the reaction [CYP2D22 protein results in increased metabolism of Dextromethorphan]; Ketoconazole inhibits the reaction [Maneb results in decreased expression of CYP2D22 protein]; Ketoconazole inhibits the reaction [Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP2D22 mRNA]]; Ketoconazole inhibits the reaction [Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP2D22 protein]]; Ketoconazole inhibits the reaction [Nicotine results in increased expression of CYP2D22 mRNA]; Ketoconazole inhibits the reaction [Nicotine results in increased expression of CYP2D22 protein]; Ketoconazole inhibits the reaction [Paraquat results in decreased expression of CYP2D22 protein]; Ketoconazole promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP2D22 mRNA]; Ketoconazole promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP2D22 protein]; Nicotine inhibits the reaction [Ketoconazole results in decreased expression of CYP2D22 mRNA]; Nicotine inhibits the reaction [Ketoconazole results in decreased expression of CYP2D22 protein] Ketoconazole results in decreased activity of CYP2D22 protein; Ketoconazole results in decreased activity of CYP2D6 protein Ketoconazole results in decreased expression of CYP2D22 mRNA; Ketoconazole results in decreased expression of CYP2D22 protein |
CTD |
PMID:15618748 PMID:16595712 PMID:18420780 PMID:19230594 PMID:19594327 PMID:22334051 PMID:24120545 More...
|
|
NCBI chr 7:115,762,662...115,771,832
|
|
G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
decreases activity |
ISO |
Ketoconazole results in decreased activity of CYP2E1 protein |
CTD |
PMID:15618748 |
|
NCBI chr 1:205,269,967...205,280,365
|
|
G |
Cyp2j4 |
cytochrome P450, family 2, subfamily j, polypeptide 4 |
decreases activity |
ISO |
Ketoconazole results in decreased activity of CYP2J2 protein |
CTD |
PMID:12851038 |
|
NCBI chr 5:116,295,691...116,323,219
|
|
G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
multiple interactions decreases activity increases metabolic processing increases expression increases response to substance decreases expression |
EXP ISO |
Ketoconazole inhibits the reaction [CYP3A2 protein results in increased metabolism of 7-benzyloxyquinoline]; Ketoconazole inhibits the reaction [Phenytoin results in increased expression of CYP3A2 protein] Ketoconazole results in decreased activity of CYP3A2 protein; Ketoconazole results in decreased activity of CYP3A4 protein [Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of BCL2 protein; [Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of MCL1 protein; [Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in increased expression of BAX protein; [Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased chemical synthesis of 1-hydroxymethylmidazolam; [Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased degradation of vanoxerine; [Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased hydroxylation of Midazolam; [Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased metabolism of Midazolam; [Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased metabolism of Testosterone; [Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased metabolism of Triazolam; Ketoconazole affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]; Ketoconazole affects the reaction [CYP3A4 polymorphism affects the metabolism of cabozantinib]; Ketoconazole affects the reaction [CYP3A4 protein alternative form affects the metabolism of acalabrutinib]; Ketoconazole affects the reaction [CYP3A4 protein alternative form affects the metabolism of vandetanib]; Ketoconazole binds to and results in decreased activity of CYP3A4 protein; Ketoconazole inhibits the reaction [3,3'-diindolylmethane results in increased expression of CYP3A4 mRNA]; Ketoconazole inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP3A4 mRNA]; Ketoconazole inhibits the reaction [[2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with NADP] results in decreased activity of CYP3A4 protein]; Ketoconazole inhibits the reaction [[Amiodarone co-treated with CYP3A4 protein] results in increased expression of CXCL8 mRNA]; Ketoconazole inhibits the reaction [[Amiodarone co-treated with CYP3A4 protein] results in increased expression of TNF mRNA]; Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac]; Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac]; Ketoconazole inhibits the reaction [[CYP3A4 protein results in increased hydroxylation of Testosterone] which results in increased chemical synthesis of 6 beta-hydroxytestosterone]; Ketoconazole inhibits the reaction [[CYP3A4 protein results in increased hydroxylation of Testosterone] which results in increased chemical synthesis of Hydroxytestosterones]; Ketoconazole inhibits the reaction [[desethylamiodarone co-treated with CYP3A4 protein] results in increased expression of CXCL8 mRNA]; Ketoconazole inhibits the reaction [[desethylamiodarone co-treated with CYP3A4 protein] results in increased expression of TNF mRNA]; Ketoconazole inhibits the reaction [Calcitriol results in increased expression of CYP3A4 protein]; Ketoconazole inhibits the reaction [Corticosterone promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]; Ketoconazole inhibits the reaction [Corticosterone results in increased expression of CYP3A4 mRNA]; Ketoconazole inhibits the reaction [CYP3A4 protein affects the metabolism of Endosulfan]; Ketoconazole inhibits the reaction [CYP3A4 protein affects the metabolism of Mefloquine]; Ketoconazole inhibits the reaction [CYP3A4 protein promotes the reaction [Oxygen deficiency results in increased expression of EPO mRNA]]; Ketoconazole inhibits the reaction [CYP3A4 protein promotes the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]]; Ketoconazole inhibits the reaction [CYP3A4 protein results in decreased abundance of Midazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in decreased methylation of adinazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in decreased methylation of mono-N-demethyladinazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in decreased susceptibility to Docetaxel]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased abundance of 1-hydroxymethylmidazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 11,12-epoxy-5,8,14-eicosatrienoic acid]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 14,15-epoxy-5,8,11-eicosatrienoic acid]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 3'-p-hydroxypaclitaxel]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 4-hydroxymidazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 5,6-epoxy-8,11,14-eicosatrienoic acid]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 6 beta-hydroxytestosterone]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 8,9-epoxyeicosatrienoic acid]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of clozapine N-oxide]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of norclozapine]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased degradation of Clopidogrel]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased degradation of Ticlopidine]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased glutathionylation of dauricine]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydrolysis of Testosterone]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Carbofuran]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Cholecalciferol]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Metoprolol]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of mono-N-desethylamiodarone]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of nefazodone]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Nifedipine]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of 8-epidiosbulbin E acetate]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of and results in decreased abundance of Quetiapine Fumarate]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Arachidonic Acid]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of bufalin]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of bufogenin]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of cabozantinib]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of carbosulfan]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of cinobufagin]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of eldecalcitol]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Felodipine]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of laquinimod]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Midazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Terfenadine]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Testosterone]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Triazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of YM 758]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of 2-oxo-clopidogrel]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of dimemorfan]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of Lithocholic Acid]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of Nifedipine]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of Paclitaxel]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Clopidogrel]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Endosulfan]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Ticlopidine]; Ketoconazole inhibits the reaction [erdafitinib results in decreased activity of CYP3A4 protein]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [piperine results in increased expression of CYP3A4 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [piperine results in increased expression of CYP3A4 protein]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 protein]]; Ketoconazole inhibits the reaction [Paclitaxel results in increased expression of CYP3A4 mRNA]; Ketoconazole inhibits the reaction [Paclitaxel results in increased expression of CYP3A4 protein]; Ketoconazole inhibits the reaction [Phenobarbital results in increased expression of CYP3A4 mRNA]; Ketoconazole inhibits the reaction [Rifampin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]; Ketoconazole inhibits the reaction [Rifampin results in increased activity of CYP3A4 protein]; Ketoconazole inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; Ketoconazole inhibits the reaction [Rifampin results in increased expression of CYP3A4 protein]; Ketoconazole inhibits the reaction [U 0126 affects the activity of CYP3A4 protein]; Ketoconazole results in increased expression of and results in decreased activity of CYP3A4 protein CYP3A4 protein results in increased metabolism of Ketoconazole Ketoconazole results in increased expression of CYP3A4 mRNA CYP3A4 protein results in increased susceptibility to Ketoconazole Ketoconazole results in decreased expression of CYP3A4 mRNA; Ketoconazole results in decreased expression of CYP3A4 protein |
CTD |
PMID:9600717 PMID:10952769 PMID:10997946 PMID:11377097 PMID:11502731 PMID:12072427 PMID:12237780 PMID:12569440 PMID:12675279 PMID:12695342 PMID:12814958 PMID:15005856 PMID:15135088 PMID:15279827 PMID:15306208 PMID:15328084 PMID:15466163 PMID:15557344 PMID:15560889 PMID:15618748 PMID:15731592 PMID:15764719 PMID:15784650 PMID:15860655 PMID:15869686 PMID:15879494 PMID:15896247 PMID:15969931 PMID:16012074 PMID:16146350 PMID:16204965 PMID:16207822 PMID:16390352 PMID:16608920 PMID:16819505 PMID:16855053 PMID:17438109 PMID:17702393 PMID:17998298 PMID:18799805 PMID:18809730 PMID:18846481 PMID:19226368 PMID:19230594 PMID:19299527 PMID:19328226 PMID:19358519 PMID:19593786 PMID:19812348 PMID:19858067 PMID:20233841 PMID:20307514 PMID:20507880 PMID:20863320 PMID:21336516 PMID:21349323 PMID:21402137 PMID:21566342 PMID:21915887 PMID:22178124 PMID:22447115 PMID:22651985 PMID:22785256 PMID:23146034 PMID:23274770 PMID:23707768 PMID:23850985 PMID:23876819 PMID:24120545 PMID:24246759 PMID:24799337 PMID:24819614 PMID:25343516 PMID:25542144 PMID:26038696 PMID:26286065 PMID:26718876 PMID:27485346 PMID:27871908 PMID:28119166 PMID:28238727 PMID:28887089 PMID:29782822 PMID:30087611 PMID:31102695 PMID:31293154 PMID:31629065 PMID:31870919 PMID:33253783 PMID:33438235 PMID:33775687 PMID:34153224 PMID:34189909 PMID:34648813 PMID:34780725 PMID:36332690 PMID:36893891 More...
|
|
NCBI chr12:14,321,771...14,343,886
|
|
G |
Cyp3a23-3a1 |
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 |
multiple interactions affects expression decreases activity |
EXP |
[Strychnine co-treated with Ketoconazole] results in decreased expression of CYP3A23-3A1 protein; Ketoconazole inhibits the reaction [CYP3A23-3A1 protein results in increased metabolism of 7-benzyloxyquinoline]; Ketoconazole inhibits the reaction [Genistein results in increased expression of CYP3A23-3A1 mRNA] Ketoconazole affects the expression of CYP3A23-3A1 mRNA Ketoconazole results in decreased activity of CYP3A23-3A1 protein |
CTD |
PMID:12814958 PMID:15879494 PMID:18355885 PMID:19858067 PMID:32185415 PMID:35358606 More...
|
|
NCBI chr12:14,369,950...14,398,803
|
|
G |
Cyp3a9 |
cytochrome P450, family 3, subfamily a, polypeptide 9 |
multiple interactions decreases activity affects response to substance |
ISO |
CYP3A5 gene polymorphism affects the reaction [Ketoconazole results in decreased metabolism of Tacrolimus]; Ketoconazole inhibits the reaction [Beclomethasone results in increased expression of CYP3A5 mRNA]; Ketoconazole inhibits the reaction [Budesonide results in increased expression of CYP3A5 mRNA]; Ketoconazole inhibits the reaction [CYP3A5 protein affects the metabolism of Alfentanil]; Ketoconazole inhibits the reaction [CYP3A5 protein results in increased hydroxylation of Testosterone]; Ketoconazole inhibits the reaction [CYP3A5 protein results in increased oxidation of Lithocholic Acid]; Ketoconazole inhibits the reaction [erdafitinib results in decreased activity of CYP3A5 protein]; Ketoconazole inhibits the reaction [flunisolide results in increased expression of CYP3A5 mRNA]; Ketoconazole inhibits the reaction [Fluticasone results in increased expression of CYP3A5 mRNA]; Ketoconazole inhibits the reaction [Triamcinolone Acetonide results in increased expression of CYP3A5 mRNA] Ketoconazole results in decreased activity of CYP3A5 protein CYP3A5 gene polymorphism affects the susceptibility to Ketoconazole |
CTD |
PMID:15557344 PMID:15731592 PMID:19384264 PMID:24555085 PMID:26302866 PMID:31102695 PMID:34189909 PMID:37788138 More...
|
|
NCBI chr12:21,919,955...21,960,160
|
|
G |
Cyp4b1 |
cytochrome P450, family 4, subfamily b, polypeptide 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of CYP4B1 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 5:129,139,019...129,176,860
|
|
G |
Cyp4f1 |
cytochrome P450, family 4, subfamily f, polypeptide 1 |
decreases activity |
ISO |
Ketoconazole results in decreased activity of CYP4F12 protein |
CTD |
PMID:14709627 |
|
NCBI chr 7:12,010,850...12,022,497
|
|
G |
Cyp4f4 |
cytochrome P450, family 4, subfamily f, polypeptide 4 |
affects expression |
EXP |
Ketoconazole affects the expression of CYP4F2 mRNA |
CTD |
PMID:18355885 |
|
NCBI chr 7:11,717,208...11,733,507
|
|
G |
Cyp51 |
cytochrome P450, family 51 |
decreases activity increases expression increases activity multiple interactions decreases response to substance |
ISO EXP |
Ketoconazole results in decreased activity of CYP51A1 protein Ketoconazole results in increased expression of CYP51 mRNA; Ketoconazole results in increased expression of CYP51 protein Ketoconazole results in increased activity of CYP51 protein CYP51A1 gene inhibits the reaction [Ketoconazole results in decreased chemical synthesis of Ergosterol]; CYP51A1 gene inhibits the reaction [Ketoconazole results in decreased metabolism of and results in increased abundance of 14-methylergosta-8,24(28)-dien-3,6-diol]; CYP51A1 gene inhibits the reaction [Ketoconazole results in decreased metabolism of and results in increased abundance of Lanosterol] [Ketoconazole results in increased activity of CYP51 protein] which results in increased abundance of Lanosterol CYP51A1 gene results in decreased susceptibility to Ketoconazole |
CTD |
PMID:12617470 PMID:16989930 PMID:17966066 PMID:18694951 PMID:28263823 PMID:29337257 More...
|
|
NCBI chr 4:30,036,956...30,055,410
|
|
G |
Cyp7a1 |
cytochrome P450 family 7 subfamily A member 1 |
multiple interactions increases expression |
EXP ISO |
[Chenodeoxycholic Acid co-treated with Ketoconazole] results in decreased expression of CYP7A1 mRNA Ketoconazole results in increased expression of CYP7A1 mRNA |
CTD |
PMID:30985903 PMID:31099283 |
|
NCBI chr 5:24,174,505...24,184,202
|
|
G |
Dcaf8 |
DDB1 and CUL4 associated factor 8 |
affects expression |
EXP |
Ketoconazole affects the expression of DCAF8 mRNA |
CTD |
PMID:18355885 |
|
NCBI chr13:87,141,940...87,199,859
|
|
G |
Dcakd |
dephospho-CoA kinase domain containing |
increases expression |
EXP |
Ketoconazole results in increased expression of DCAKD mRNA |
CTD |
PMID:36653537 |
|
NCBI chr10:88,457,829...88,489,011
|
|
G |
Ddb1 |
damage-specific DNA binding protein 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of DDB1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 1:207,252,890...207,278,685
|
|
G |
Ddit3 |
DNA-damage inducible transcript 3 |
increases expression multiple interactions affects expression |
ISO |
Ketoconazole results in increased expression of DDIT3 mRNA EIF2S1 protein mutant form inhibits the reaction [Ketoconazole results in increased expression of DDIT3 mRNA] Ketoconazole affects the expression of DDIT3 mRNA |
CTD |
PMID:16330322 PMID:31099283 PMID:36621641 |
|
NCBI chr 7:65,001,695...65,006,517
|
|
G |
Depp1 |
DEPP autophagy regulator 1 |
decreases expression increases expression |
ISO |
Ketoconazole results in decreased expression of DEPP1 mRNA Ketoconazole results in increased expression of DEPP1 mRNA |
CTD |
PMID:15342952 PMID:17175557 |
|
NCBI chr 4:149,910,794...149,913,013
|
|
G |
Desi2 |
desumoylating isopeptidase 2 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of DESI2 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr13:89,961,767...90,011,255
|
|
G |
Dgka |
diacylglycerol kinase, alpha |
decreases expression |
EXP |
Ketoconazole results in decreased expression of DGKA mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 7:1,733,247...1,761,181
|
|
G |
Dhcr7 |
7-dehydrocholesterol reductase |
increases expression |
EXP ISO |
Ketoconazole results in increased expression of DHCR7 mRNA |
CTD |
PMID:28263823 PMID:36621641 PMID:36653537 |
|
NCBI chr 1:199,015,081...199,031,055
|
|
G |
Dhrs3 |
dehydrogenase/reductase 3 |
increases expression |
EXP |
Ketoconazole results in increased expression of DHRS3 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 5:156,747,939...156,782,420
|
|
G |
Dhx9 |
DExH-box helicase 9 |
increases expression |
ISO |
Ketoconazole results in increased expression of DHX9 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr13:65,602,322...65,639,098
|
|
G |
Dlat |
dihydrolipoamide S-acetyltransferase |
decreases expression |
EXP |
Ketoconazole results in decreased expression of DLAT mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 8:59,875,537...59,900,947
|
|
G |
Dlc1 |
DLC1 Rho GTPase activating protein |
decreases expression |
EXP |
Ketoconazole results in decreased expression of DLC1 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr16:55,246,716...55,671,441
|
|
G |
Dlk1 |
delta like non-canonical Notch ligand 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of DLK1 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 6:128,410,216...128,417,518
|
|
G |
Dmc1 |
DNA meiotic recombinase 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of DMC1 mRNA |
CTD |
PMID:16574651 |
|
NCBI chr 7:111,124,888...111,167,465
|
|
G |
Dmxl1 |
Dmx-like 1 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of DMXL1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr18:42,993,292...43,163,457
|
|
G |
Dnase1l1 |
deoxyribonuclease 1-like 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of DNASE1L1 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr X:152,056,942...152,065,518
|
|
G |
Dnmt3a |
DNA methyltransferase 3 alpha |
increases expression decreases expression |
EXP |
Ketoconazole results in increased expression of DNMT3A mRNA Ketoconazole results in decreased expression of DNMT3A mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 6:32,507,316...32,621,678
|
|
G |
Dnmt3b |
DNA methyltransferase 3 beta |
decreases expression |
EXP |
Ketoconazole results in decreased expression of DNMT3B mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 3:142,130,588...142,169,128
|
|
G |
Dock1 |
dedicator of cyto-kinesis 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of DOCK1 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr 1:189,467,143...189,983,777
|
|
G |
Dock6 |
dedicator of cytokinesis 6 |
increases expression |
EXP |
Ketoconazole results in increased expression of DOCK6 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr 8:20,342,430...20,394,660
|
|
G |
Dok7 |
docking protein 7 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of DOK7 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr14:75,665,444...75,699,413
|
|
G |
Dpcd |
deleted in primary ciliary dyskinesia |
increases expression |
ISO |
Ketoconazole results in increased expression of DPCD mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 1:244,408,766...244,426,891
|
|
G |
Drd4 |
dopamine receptor D4 |
decreases expression multiple interactions |
ISO |
Ketoconazole results in decreased expression of DRD4 mRNA Ketoconazole inhibits the reaction [FSHB protein results in increased expression of DRD4 mRNA]; Metribolone inhibits the reaction [Ketoconazole results in decreased expression of DRD4 mRNA] |
CTD |
PMID:19587329 |
|
NCBI chr 1:205,825,937...205,829,124
|
|
G |
Drosha |
drosha ribonuclease III |
decreases expression |
EXP |
Ketoconazole results in decreased expression of DROSHA mRNA |
CTD |
PMID:36653537 |
|
NCBI chr 2:61,864,886...61,976,688
|
|
G |
Dusp1 |
dual specificity phosphatase 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of DUSP1 mRNA |
CTD |
PMID:25787151 |
|
NCBI chr10:17,184,853...17,187,646
|
|
G |
Ednrb |
endothelin receptor type B |
increases expression |
EXP |
Ketoconazole results in increased expression of EDNRB mRNA |
CTD |
PMID:36653537 |
|
NCBI chr15:87,055,490...87,086,765
|
|
G |
Egf |
epidermal growth factor |
increases uptake multiple interactions |
ISO |
Ketoconazole results in increased uptake of EGF protein Ketoconazole inhibits the reaction [EGF protein results in increased uptake of and results in increased degradation of EGFR protein] |
CTD |
PMID:23125191 |
|
NCBI chr 2:220,893,660...220,976,331
|
|
G |
Egfr |
epidermal growth factor receptor |
multiple interactions decreases expression |
ISO EXP |
Ketoconazole inhibits the reaction [EGF protein results in increased uptake of and results in increased degradation of EGFR protein] Ketoconazole results in decreased expression of EGFR mRNA |
CTD |
PMID:23125191 PMID:37077353 |
|
NCBI chr14:95,378,626...95,551,358
|
|
G |
Egln1 |
egl-9 family hypoxia-inducible factor 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of EGLN1 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr19:52,867,900...52,907,308
|
|
G |
Egln3 |
egl-9 family hypoxia-inducible factor 3 |
increases expression |
EXP |
Ketoconazole results in increased expression of EGLN3 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 6:71,650,297...71,675,766
|
|
G |
Eif1ad |
eukaryotic translation initiation factor 1A domain containing |
increases expression |
ISO |
Ketoconazole results in increased expression of EIF1AD mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 1:212,103,715...212,109,015
|
|
G |
Eif2ak3 |
eukaryotic translation initiation factor 2 alpha kinase 3 |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [Tunicamycin results in increased phosphorylation of EIF2AK3 protein] |
CTD |
PMID:16330322 |
|
NCBI chr 4:104,363,838...104,425,271
|
|
G |
Eif2s1 |
eukaryotic translation initiation factor 2 subunit alpha |
multiple interactions |
ISO |
EIF2S1 protein mutant form inhibits the reaction [Ketoconazole results in increased expression of DDIT3 mRNA]; EIF2S1 protein mutant form promotes the reaction [Ketoconazole results in increased expression of IDI1 mRNA]; EIF2S1 protein mutant form promotes the reaction [Ketoconazole results in increased expression of MSMO1 mRNA] |
CTD |
PMID:16330322 |
|
NCBI chr 6:103,405,880...103,430,549
|
|
G |
Eif3e |
eukaryotic translation initiation factor 3 subunit E |
decreases expression |
ISO |
Ketoconazole results in decreased expression of EIF3E mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 7:74,339,848...74,372,483
|
|
G |
Eif3m |
eukaryotic translation initiation factor 3, subunit M |
increases expression |
ISO |
Ketoconazole results in increased expression of EIF3M mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 3:111,879,589...111,897,193
|
|
G |
Eif4b |
eukaryotic translation initiation factor 4B |
affects expression |
EXP |
Ketoconazole affects the expression of EIF4B mRNA |
CTD |
PMID:18355885 |
|
NCBI chr 7:135,085,259...135,107,054
|
|
G |
Eif4ebp1 |
eukaryotic translation initiation factor 4E binding protein 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of EIF4EBP1 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr16:71,495,457...71,508,845
|
|
G |
Elac1 |
elaC ribonuclease Z 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of ELAC1 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr18:67,321,231...67,341,358
|
|
G |
Elovl5 |
ELOVL fatty acid elongase 5 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of ELOVL5 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 8:78,790,846...78,857,307
|
|
G |
Elovl6 |
ELOVL fatty acid elongase 6 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of ELOVL6 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 2:220,738,095...220,845,528
|
|
G |
Enpp3 |
ectonucleotide pyrophosphatase/phosphodiesterase 3 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of ENPP3 mRNA |
CTD |
PMID:31099283 |
|
NCBI chr 1:20,563,700...20,635,044
|
|
G |
Epas1 |
endothelial PAS domain protein 1 |
increases expression |
EXP ISO |
Ketoconazole results in increased expression of EPAS1 mRNA |
CTD |
PMID:36621641 PMID:37077353 |
|
NCBI chr 6:13,543,252...13,626,147
|
|
G |
Epb41l3 |
erythrocyte membrane protein band 4.1-like 3 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of EPB41L3 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr 9:116,502,864...116,707,274
|
|
G |
Ephx1 |
epoxide hydrolase 1 |
affects expression increases expression |
EXP |
Ketoconazole affects the expression of EPHX1 mRNA Ketoconazole results in increased expression of EPHX1 mRNA |
CTD |
PMID:18355885 PMID:37077353 |
|
NCBI chr13:95,246,079...95,275,852
|
|
G |
Epo |
erythropoietin |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [CYP3A4 protein promotes the reaction [Oxygen deficiency results in increased expression of EPO mRNA]]; Ketoconazole inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA] |
CTD |
PMID:21566342 |
|
NCBI chr12:19,204,258...19,207,948
|
|
G |
Eppin |
epididymal peptidase inhibitor |
multiple interactions decreases expression |
ISO |
Ketoconazole inhibits the reaction [FSHB protein results in increased expression of EPPIN mRNA]; Metribolone inhibits the reaction [Ketoconazole results in decreased expression of EPPIN mRNA] |
CTD |
PMID:19587329 |
|
NCBI chr 3:153,312,396...153,319,310
|
|
G |
Eral1 |
Era-like 12S mitochondrial rRNA chaperone 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of ERAL1 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr10:62,961,725...62,968,747
|
|
G |
Erc1 |
ELKS/RAB6-interacting/CAST family member 1 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of ERC1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 4:152,763,664...153,055,724
|
|
G |
Ereg |
epiregulin |
increases expression |
ISO |
Ketoconazole results in increased expression of EREG mRNA |
CTD |
PMID:32816093 |
|
NCBI chr14:17,311,485...17,325,260
|
|
G |
Ero1a |
endoplasmic reticulum oxidoreductase 1 alpha |
decreases expression |
EXP |
Ketoconazole results in decreased expression of ERO1A mRNA |
CTD |
PMID:37077353 |
|
NCBI chr15:18,495,037...18,530,440
|
|
G |
Erp29 |
endoplasmic reticulum protein 29 |
affects expression |
EXP |
Ketoconazole affects the expression of ERP29 mRNA |
CTD |
PMID:18355885 |
|
NCBI chr12:40,750,177...40,756,607
|
|
G |
Esco2 |
establishment of sister chromatid cohesion N-acetyltransferase 2 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of ESCO2 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr15:44,210,124...44,230,785
|
|
G |
Esr1 |
estrogen receptor 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of ESR1 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 1:43,511,685...43,904,454
|
|
G |
Esrra |
estrogen related receptor, alpha |
increases expression |
EXP |
Ketoconazole results in increased expression of ESRRA mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 1:204,104,100...204,114,182
|
|
G |
Ets1 |
ETS proto-oncogene 1, transcription factor |
decreases expression |
EXP |
Ketoconazole results in decreased expression of ETS1 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 8:39,303,936...39,426,022
|
|
G |
Exoc6b |
exocyst complex component 6B |
increases expression |
ISO |
Ketoconazole results in increased expression of EXOC6B mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 4:117,094,741...117,550,221
|
|
G |
Ezh1 |
enhancer of zeste 1 polycomb repressive complex 2 subunit |
increases expression |
EXP |
Ketoconazole results in increased expression of EZH1 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr10:86,126,023...86,162,001
|
|
G |
Ezh2 |
enhancer of zeste 2 polycomb repressive complex 2 subunit |
decreases expression |
EXP |
Ketoconazole results in decreased expression of EZH2 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 4:76,624,399...76,687,362
|
|
G |
F3 |
coagulation factor III, tissue factor |
increases expression |
ISO |
Ketoconazole results in increased expression of F3 protein |
CTD |
PMID:25569083 |
|
NCBI chr 2:212,511,675...212,523,375
|
|
G |
Fabp1 |
fatty acid binding protein 1 |
increases expression |
ISO EXP |
Ketoconazole results in increased expression of FABP1 mRNA |
CTD |
PMID:15342952 PMID:17175557 PMID:17567588 PMID:36653537 |
|
NCBI chr 4:104,744,302...104,753,119
|
|
G |
Fabp3 |
fatty acid binding protein 3 |
increases expression |
EXP |
Ketoconazole results in increased expression of FABP3 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 5:142,651,962...142,658,707
|
|
G |
Fabp4 |
fatty acid binding protein 4 |
increases expression |
EXP |
Ketoconazole results in increased expression of FABP4 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 2:93,488,251...93,492,961
|
|
G |
Fabp5 |
fatty acid binding protein 5 |
increases expression |
EXP ISO |
Ketoconazole results in increased expression of FABP5 mRNA |
CTD |
PMID:31099283 PMID:37077353 |
|
NCBI chr 2:91,765,056...91,768,716
|
|
G |
Faf1 |
Fas associated factor 1 |
increases expression |
ISO EXP |
Ketoconazole results in increased expression of FAF1 mRNA |
CTD |
PMID:25808816 |
|
NCBI chr 5:124,426,032...124,790,014
|
|
G |
Fam20c |
FAM20C, golgi associated secretory pathway kinase |
increases expression |
EXP |
Ketoconazole results in increased expression of FAM20C mRNA |
CTD |
PMID:37077353 |
|
NCBI chr12:20,940,654...20,999,072
|
|
G |
Fas |
Fas cell surface death receptor |
increases expression multiple interactions |
ISO EXP |
Ketoconazole results in increased expression of FAS mRNA Ketoconazole inhibits the reaction [CYP26A1 protein inhibits the reaction [Tretinoin results in increased activity of FAS protein]] |
CTD |
PMID:15703382 PMID:25808816 |
|
NCBI chr 1:241,212,155...241,245,774
|
|
G |
Fbxl14 |
F-box and leucine-rich repeat protein 14 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of FBXL14 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr 4:152,662,542...152,666,360
|
|
G |
Fbxl15 |
F-box and leucine-rich repeat protein 15 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of FBXL15 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 1:245,189,732...245,191,973
|
|
G |
Fbxo21 |
F-box protein 21 |
increases expression |
ISO |
Ketoconazole results in increased expression of FBXO21 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr12:38,570,878...38,605,133
|
|
G |
Fbxw2 |
F-box and WD repeat domain containing 2 |
increases expression |
ISO |
Ketoconazole results in increased expression of FBXW2 mRNA |
CTD |
PMID:31099283 |
|
NCBI chr 3:18,088,859...18,114,387
|
|
G |
Fdft1 |
farnesyl diphosphate farnesyl transferase 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of FDFT1 mRNA |
CTD |
PMID:28263823 |
|
NCBI chr15:41,588,114...41,616,168
|
|
G |
Fdps |
farnesyl diphosphate synthase |
increases expression |
EXP |
Ketoconazole results in increased expression of FDPS mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 2:176,795,192...176,804,816
|
|
G |
Fdx1 |
ferredoxin 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of FDX1 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr 8:52,268,536...52,287,344
|
|
G |
Fezf1 |
Fez family zinc finger 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of FEZF1 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 4:51,762,751...51,766,078
|
|
G |
Fgfbp3 |
fibroblast growth factor binding protein 3 |
increases expression |
EXP |
Ketoconazole results in increased expression of FGFBP3 mRNA |
CTD |
PMID:28263823 |
|
NCBI chr 1:234,644,023...234,646,028
|
|
G |
Flad1 |
flavin adenine dinucleotide synthetase 1 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of FLAD1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 2:174,819,451...174,828,921
|
|
G |
Fn1 |
fibronectin 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of FN1 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 9:80,645,507...80,714,200
|
|
G |
Fndc4 |
fibronectin type III domain containing 4 |
increases expression |
ISO |
Ketoconazole results in increased expression of FNDC4 mRNA |
CTD |
PMID:15342952 PMID:17175557 PMID:17567588 |
|
NCBI chr 6:25,077,155...25,080,812
|
|
G |
Fosl1 |
FOS like 1, AP-1 transcription factor subunit |
decreases expression increases expression |
EXP ISO |
Ketoconazole results in decreased expression of FOSL1 mRNA Ketoconazole results in increased expression of FOSL1 mRNA |
CTD |
PMID:25787151 PMID:31099283 |
|
NCBI chr 1:212,183,885...212,192,391
|
|
G |
Foxa2 |
forkhead box A2 |
increases expression |
EXP |
Ketoconazole results in increased expression of FOXA2 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 3:135,470,123...135,474,326
|
|
G |
Foxl2 |
forkhead box L2 |
increases expression |
ISO |
Ketoconazole results in increased expression of FOXL2 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 8:99,512,971...99,514,500
|
|
G |
Foxp2 |
forkhead box P2 |
increases expression |
EXP |
Ketoconazole results in increased expression of FOXP2 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr 4:44,099,848...44,677,700
|
|
G |
Fscn1 |
fascin actin-bundling protein 1 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of FSCN1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr12:16,710,601...16,723,734
|
|
G |
Fshb |
follicle stimulating hormone subunit beta |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [FSHB protein results in increased expression of DRD4 mRNA]; Ketoconazole inhibits the reaction [FSHB protein results in increased expression of EPPIN mRNA]; Ketoconazole inhibits the reaction [FSHB protein results in increased expression of GPD1 mRNA]; Ketoconazole inhibits the reaction [FSHB protein results in increased expression of RHOX5 mRNA] |
CTD |
PMID:19587329 |
|
NCBI chr 3:114,003,262...114,007,072
|
|
G |
Fyco1 |
FYVE and coiled-coil domain autophagy adaptor 1 |
increases expression decreases expression |
ISO EXP |
Ketoconazole results in increased expression of FYCO1 mRNA Ketoconazole results in decreased expression of FYCO1 mRNA |
CTD |
PMID:36621641 PMID:36653537 |
|
NCBI chr 8:132,289,538...132,356,810
|
|
G |
G0s2 |
G0/G1switch 2 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of G0S2 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr13:107,335,036...107,335,948
|
|
G |
G6pc1 |
glucose-6-phosphatase catalytic subunit 1 |
affects expression |
EXP |
Ketoconazole affects the expression of G6PC1 mRNA |
CTD |
PMID:18289764 |
|
NCBI chr10:86,307,400...86,318,766
|
|
G |
G6pd |
glucose-6-phosphate dehydrogenase |
increases expression |
ISO |
Ketoconazole results in increased expression of G6PD mRNA |
CTD |
PMID:25399406 |
|
NCBI chr X:157,352,364...157,372,144
|
|
G |
Gabarapl2 |
GABA type A receptor associated protein like 2 |
increases expression |
EXP |
Ketoconazole results in increased expression of GABARAPL2 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr19:56,819,826...56,830,662
|
|
G |
Gabbr1 |
gamma-aminobutyric acid type B receptor subunit 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of GABBR1 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr20:1,469,779...1,499,352
|
|
G |
Gabbr2 |
gamma-aminobutyric acid type B receptor subunit 2 |
increases expression |
EXP |
Ketoconazole results in increased expression of GABBR2 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 5:60,947,517...61,288,104
|
|
G |
Gabra4 |
gamma-aminobutyric acid type A receptor subunit alpha 4 |
increases expression |
EXP |
Ketoconazole results in increased expression of GABRA4 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr14:36,590,782...36,667,724
|
|
G |
Gabra5 |
gamma-aminobutyric acid type A receptor subunit alpha 5 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of GABRA5 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 1:108,268,728...108,381,670
|
|
G |
Gabrd |
gamma-aminobutyric acid type A receptor subunit delta |
increases expression |
EXP |
Ketoconazole results in increased expression of GABRD mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 5:171,240,813...171,252,709
|
|
G |
Gabre |
gamma-aminobutyric acid type A receptor subunit epsilon |
decreases expression |
EXP |
Ketoconazole results in decreased expression of GABRE mRNA |
CTD |
PMID:37077353 |
|
NCBI chr X:150,060,035...150,078,773
|
|
G |
Gabrq |
gamma-aminobutyric acid type A receptor subunit theta |
decreases expression |
EXP |
Ketoconazole results in decreased expression of GABRQ mRNA |
CTD |
PMID:37077353 |
|
NCBI chr X:150,696,161...150,712,948
|
|
G |
Gad1 |
glutamate decarboxylase 1 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of GAD1 mRNA |
CTD |
PMID:31099283 |
|
NCBI chr 3:75,777,260...75,818,099
|
|
G |
Gadd45a |
growth arrest and DNA-damage-inducible, alpha |
increases expression |
EXP |
Ketoconazole results in increased expression of GADD45A mRNA |
CTD |
PMID:16483768 |
|
NCBI chr 4:97,484,497...97,486,799
|
|
G |
Gapdh |
glyceraldehyde-3-phosphate dehydrogenase |
increases expression |
EXP |
Ketoconazole results in increased expression of GAPDH mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 4:157,962,312...157,967,158
|
|
G |
Gata3 |
GATA binding protein 3 |
increases expression |
EXP |
Ketoconazole results in increased expression of GATA3 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr17:68,643,760...68,666,000
|
|
G |
Gck |
glucokinase |
decreases expression |
EXP |
Ketoconazole results in decreased expression of GCK mRNA |
CTD |
PMID:37077353 |
|
NCBI chr14:84,999,019...85,041,098
|
|
G |
Gckr |
glucokinase regulator |
affects expression |
EXP |
Ketoconazole affects the expression of GCKR mRNA |
CTD |
PMID:18355885 |
|
NCBI chr 6:25,044,592...25,075,834
|
|
G |
Gdi2 |
GDP dissociation inhibitor 2 |
increases expression |
ISO |
Ketoconazole results in increased expression of GDI2 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr17:71,559,460...71,586,147
|
|
G |
Gdpd3 |
glycerophosphodiester phosphodiesterase domain containing 3 |
increases expression |
ISO |
Ketoconazole results in increased expression of GDPD3 mRNA |
CTD |
PMID:15342952 PMID:17175557 |
|
NCBI chr 1:181,373,505...181,383,063
|
|
G |
Gfus |
GDP-L-fucose synthase |
increases expression |
ISO |
Ketoconazole results in increased expression of GFUS mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 7:107,612,087...107,617,005
|
|
G |
Ghr |
growth hormone receptor |
decreases expression |
EXP |
Ketoconazole results in decreased expression of GHR mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 2:52,541,452...52,804,960
|
|
G |
Gjb1 |
gap junction protein, beta 1 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of GJB1 mRNA |
CTD |
PMID:31099283 |
|
NCBI chr X:66,501,848...66,509,783
|
|
G |
Gjb2 |
gap junction protein, beta 2 |
increases expression |
EXP |
Ketoconazole results in increased expression of GJB2 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr15:31,260,390...31,278,222
|
|
G |
Gls2 |
glutaminase 2 |
affects expression |
EXP |
Ketoconazole affects the expression of GLS2 mRNA |
CTD |
PMID:18355885 |
|
NCBI chr 7:617,252...633,424
|
|
G |
Gnai1 |
G protein subunit alpha i1 |
increases expression |
EXP |
Ketoconazole results in increased expression of GNAI1 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 4:17,706,061...17,790,176
|
|
G |
Gng11 |
G protein subunit gamma 11 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of GNG11 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 4:32,023,003...32,028,443
|
|
G |
Gnl3 |
G protein nucleolar 3 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of GNL3 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr16:6,207,402...6,213,491
|
|
G |
Gnrh1 |
gonadotropin releasing hormone 1 |
affects secretion |
EXP |
Ketoconazole affects the secretion of GNRH1 protein |
CTD |
PMID:37077353 |
|
NCBI chr15:41,972,482...41,976,690
|
|
G |
Golga3 |
golgin A3 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of GOLGA3 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr12:46,452,409...46,500,509
|
|
G |
Golm1 |
golgi membrane protein 1 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of GOLM1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr17:4,995,925...5,044,329
|
|
G |
Golph3l |
golgi phosphoprotein 3-like |
decreases expression |
ISO |
Ketoconazole results in decreased expression of GOLPH3L mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 2:183,151,941...183,183,094
|
|
G |
Got1 |
glutamic-oxaloacetic transaminase 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of GOT1 protein |
CTD |
PMID:31099283 |
|
NCBI chr 1:252,306,541...252,337,622
|
|
G |
Got2 |
glutamic-oxaloacetic transaminase 2 |
affects expression |
EXP |
Ketoconazole affects the expression of GOT2 mRNA |
CTD |
PMID:18355885 |
|
NCBI chr19:9,180,428...9,206,113
|
|
G |
Gpam |
glycerol-3-phosphate acyltransferase, mitochondrial |
decreases expression |
EXP |
Ketoconazole results in decreased expression of GPAM mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 1:264,111,599...264,176,112
|
|
G |
Gpatch2 |
G patch domain containing 2 |
increases expression |
ISO |
Ketoconazole results in increased expression of GPATCH2 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr13:101,316,413...101,457,109
|
|
G |
Gpd1 |
glycerol-3-phosphate dehydrogenase 1 |
multiple interactions decreases expression increases expression |
ISO EXP |
Ketoconazole inhibits the reaction [FSHB protein results in increased expression of GPD1 mRNA]; Metribolone inhibits the reaction [Ketoconazole results in decreased expression of GPD1 mRNA] Ketoconazole results in increased expression of GPD1 mRNA |
CTD |
PMID:19587329 PMID:37077353 |
|
NCBI chr 7:130,842,526...130,851,530
|
|
G |
Gpr12 |
G protein-coupled receptor 12 |
increases expression |
EXP |
Ketoconazole results in increased expression of GPR12 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr12:8,522,709...8,525,875
|
|
G |
Gpr17 |
G protein-coupled receptor 17 |
decreases expression increases expression |
EXP |
Ketoconazole results in decreased expression of GPR17 mRNA Ketoconazole results in increased expression of GPR17 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr18:23,576,232...23,583,153
|
|
G |
Gpr37 |
G protein-coupled receptor 37 |
increases expression |
EXP |
Ketoconazole results in increased expression of GPR37 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 4:54,138,860...54,160,927
|
|
G |
Gpr6 |
G protein-coupled receptor 6 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of GPR6 mRNA |
CTD |
PMID:31099283 |
|
NCBI chr20:44,489,853...44,492,624
|
|
G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions increases expression |
EXP ISO |
Ketoconazole inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein] Ketoconazole inhibits the reaction [columbin results in increased activity of GPT protein]; Ketoconazole promotes the reaction [gelsemine results in increased expression of GPT protein] Ketoconazole results in increased expression of GPT protein |
CTD |
PMID:31099283 PMID:31168027 PMID:32162908 PMID:34627953 |
|
NCBI chr 7:110,295,599...110,300,134
|
|
G |
Gpx4 |
glutathione peroxidase 4 |
increases expression |
EXP |
Ketoconazole results in increased expression of GPX4 mRNA |
CTD |
PMID:17679765 |
|
NCBI chr 7:10,300,833...10,303,629
|
|
G |
Grb14 |
growth factor receptor bound protein 14 |
affects expression |
EXP |
Ketoconazole affects the expression of GRB14 mRNA |
CTD |
PMID:18355885 |
|
NCBI chr 3:49,568,210...49,683,805
|
|
G |
Greb1 |
growth regulating estrogen receptor binding 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of GREB1 mRNA |
CTD |
PMID:35307500 |
|
NCBI chr 6:39,440,522...39,562,364
|
|
G |
Grid2ip |
Grid2 interacting protein |
increases expression |
EXP |
Ketoconazole results in increased expression of GRID2IP mRNA |
CTD |
PMID:37077353 |
|
NCBI chr12:11,166,567...11,203,765
|
|
G |
Grik2 |
glutamate ionotropic receptor kainate type subunit 2 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of GRIK2 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr20:53,717,564...54,415,283
|
|
G |
Grina |
glutamate ionotropic receptor NMDA type subunit associated protein 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of GRINA mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 7:107,962,194...107,965,372
|
|
G |
Grm3 |
glutamate metabotropic receptor 3 |
increases expression |
EXP |
Ketoconazole results in increased expression of GRM3 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 4:24,364,854...24,643,972
|
|
G |
Grm4 |
glutamate metabotropic receptor 4 |
affects expression |
EXP |
Ketoconazole affects the expression of GRM4 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr20:5,484,172...5,572,821
|
|
G |
Gsr |
glutathione-disulfide reductase |
increases expression multiple interactions |
EXP |
Ketoconazole results in increased expression of GSR mRNA [Ketoconazole co-treated with Carbon Tetrachloride] results in increased expression of GSR mRNA |
CTD |
PMID:31168027 |
|
NCBI chr16:65,185,574...65,228,742
|
|
G |
Gsta1 |
glutathione S-transferase alpha 1 |
multiple interactions decreases expression |
ISO EXP |
Ketoconazole inhibits the reaction [Phenobarbital results in increased expression of GSTA1 mRNA]; Ketoconazole inhibits the reaction [Rifampin results in increased expression of GSTA1 mRNA] Ketoconazole results in decreased expression of GSTA1 mRNA Ketoconazole inhibits the reaction [Carbon Tetrachloride results in decreased expression of GSTA1 mRNA]; Ketoconazole inhibits the reaction [Genistein results in increased expression of GSTA1 mRNA] |
CTD |
PMID:16608920 PMID:31168027 PMID:32185415 |
|
NCBI chr 9:23,703,476...23,720,121
|
|
G |
Gsta2 |
glutathione S-transferase alpha 2 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of GSTA2 mRNA |
CTD |
PMID:16608920 |
|
NCBI chr 8:79,184,535...79,196,827
|
|
G |
Gstm1 |
glutathione S-transferase mu 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of GSTM1 protein |
CTD |
PMID:17966066 |
|
NCBI chr 2:198,338,005...198,346,007
|
|
G |
Gstm2 |
glutathione S-transferase mu 2 |
affects expression |
EXP |
Ketoconazole affects the expression of GSTM2 mRNA |
CTD |
PMID:18289764 |
|
NCBI chr 2:195,624,015...195,628,774
|
|
G |
Gstp1 |
glutathione S-transferase pi 1 |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac]; Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac] |
CTD |
PMID:24246759 |
|
NCBI chr 1:210,767,237...210,770,242
|
|
G |
Gtpbp8 |
GTP binding protein 8 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of GTPBP8 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr11:55,945,778...55,955,743
|
|
G |
Gzf1 |
GDNF-inducible zinc finger protein 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of GZF1 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr 3:136,119,004...136,131,223
|
|
G |
H6pd |
hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) |
decreases expression increases expression |
EXP ISO |
Ketoconazole results in decreased expression of H6PD mRNA Ketoconazole results in increased expression of H6PD mRNA |
CTD |
PMID:36621641 PMID:37077353 |
|
NCBI chr 5:160,434,499...160,470,203
|
|
G |
Hadha |
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha |
increases expression decreases expression |
EXP ISO |
Ketoconazole results in increased expression of HADHA mRNA Ketoconazole results in decreased expression of HADHA mRNA |
CTD |
PMID:36621641 PMID:37077353 |
|
NCBI chr 6:26,187,969...26,227,605
|
|
G |
Hadhb |
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta |
increases expression |
EXP |
Ketoconazole results in increased expression of HADHB mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 6:31,873,404...31,907,557
|
|
G |
Hal |
histidine ammonia lyase |
affects expression |
EXP |
Ketoconazole affects the expression of HAL mRNA |
CTD |
PMID:18355885 |
|
NCBI chr 7:28,007,449...28,037,701
|
|
G |
Hamp |
hepcidin antimicrobial peptide |
multiple interactions decreases expression |
ISO |
Ketoconazole inhibits the reaction [IL6 protein results in increased expression of HAMP mRNA] Ketoconazole results in decreased expression of HAMP protein |
CTD |
PMID:17966066 |
|
NCBI chr 1:95,298,332...95,300,271
|
|
G |
Has2 |
hyaluronan synthase 2 |
increases expression |
ISO |
Ketoconazole results in increased expression of HAS2 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 7:90,002,929...90,028,933
|
|
G |
Havcr1 |
hepatitis A virus cellular receptor 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of HAVCR1 mRNA |
CTD |
PMID:18289764 |
|
NCBI chr10:31,118,667...31,151,730
|
|
G |
Hbb |
hemoglobin subunit beta |
decreases expression |
EXP |
Ketoconazole results in decreased expression of HBB mRNA; Ketoconazole results in decreased expression of HBB-B1 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr 1:167,662,310...167,663,721
|
|
G |
Hebp1 |
heme binding protein 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of HEBP1 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 4:169,705,665...169,735,199
|
|
G |
Hes6 |
hes family bHLH transcription factor 6 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of HES6 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr 9:99,449,375...99,451,343
|
|
G |
Hibadh |
3-hydroxyisobutyrate dehydrogenase |
increases expression |
ISO |
Ketoconazole results in increased expression of HIBADH mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 4:81,649,180...81,747,244
|
|
G |
Hif1an |
hypoxia inducible factor 1 subunit alpha inhibitor |
increases expression |
ISO |
Ketoconazole results in increased expression of HIF1AN mRNA |
CTD |
PMID:31099283 |
|
NCBI chr 1:243,419,175...243,440,464
|
|
G |
Hist1h4b |
histone cluster 1 H4 family member B |
decreases expression |
EXP |
Ketoconazole results in decreased expression of HIST1H4B mRNA |
CTD |
PMID:36653537 |
|
NCBI chr17:47,176,246...47,180,690
|
|
G |
Hivep1 |
HIVEP zinc finger 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of HIVEP1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr17:22,585,016...22,714,517
|
|
G |
Hmga2 |
high mobility group AT-hook 2 |
increases expression |
ISO |
Ketoconazole results in increased expression of HMGA2 mRNA |
CTD |
PMID:31099283 |
|
NCBI chr 7:57,762,710...57,884,555
|
|
G |
Hmgb2 |
high mobility group box 2 |
affects expression |
EXP |
Ketoconazole affects the expression of HMGB2 mRNA |
CTD |
PMID:18355885 |
|
NCBI chr16:37,721,374...37,723,950
|
|
G |
Hmgcr |
3-hydroxy-3-methylglutaryl-CoA reductase |
increases activity multiple interactions decreases activity decreases expression increases expression |
EXP ISO |
Ketoconazole results in increased activity of HMGCR protein [Colforsin co-treated with Ketoconazole] results in decreased expression of HMGCR mRNA Ketoconazole results in decreased activity of HMGCR protein Ketoconazole results in decreased expression of HMGCR mRNA Ketoconazole results in increased expression of HMGCR mRNA |
CTD |
PMID:9199277 PMID:12617470 PMID:16935330 PMID:28263823 PMID:37077353 |
|
NCBI chr 2:29,732,163...29,754,276
|
|
G |
Hmgcs1 |
3-hydroxy-3-methylglutaryl-CoA synthase 1 |
increases expression |
EXP ISO |
Ketoconazole results in increased expression of HMGCS1 mRNA |
CTD |
PMID:28263823 PMID:31099283 |
|
NCBI chr 2:53,379,457...53,399,807
|
|
G |
Hmgcs2 |
3-hydroxy-3-methylglutaryl-CoA synthase 2 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of HMGCS2 mRNA |
CTD |
PMID:31099283 |
|
NCBI chr 2:185,875,609...185,903,505
|
|
G |
Hmox1 |
heme oxygenase 1 |
affects expression multiple interactions increases expression |
EXP ISO |
Ketoconazole affects the expression of HMOX1 mRNA Ketoconazole inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 protein] [Ketoconazole co-treated with Carbon Tetrachloride] results in increased expression of HMOX1 protein; Ketoconazole inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA] Ketoconazole results in increased expression of HMOX1 mRNA |
CTD |
PMID:12763371 PMID:18289764 PMID:22659318 PMID:31168027 PMID:37077353 |
|
NCBI chr19:13,452,365...13,479,823
|
|
G |
Hormad1 |
HORMA domain containing 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of HORMAD1 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr 2:183,115,815...183,152,383
|
|
G |
Hoxa4 |
homeo box A4 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of HOXA4 mRNA |
CTD |
PMID:31099283 |
|
NCBI chr 4:81,289,677...81,291,685
|
|
G |
Hpn |
hepsin |
increases expression |
ISO |
Ketoconazole results in increased expression of HPN mRNA |
CTD |
PMID:15342952 |
|
NCBI chr 1:86,337,085...86,352,785
|
|
G |
Hras |
HRas proto-oncogene, GTPase |
decreases expression |
ISO |
Ketoconazole results in decreased expression of HRAS mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 1:205,712,625...205,729,406
|
|
G |
Hsd11b2 |
hydroxysteroid 11-beta dehydrogenase 2 |
decreases activity |
ISO |
Ketoconazole results in decreased activity of HSD11B2 protein |
CTD |
PMID:10664531 |
|
NCBI chr19:50,307,569...50,312,812
|
|
G |
Hsd17b2 |
hydroxysteroid (17-beta) dehydrogenase 2 |
multiple interactions |
ISO |
Ketoconazole promotes the reaction [Calcitriol results in increased expression of HSD17B2 mRNA] |
CTD |
PMID:12040012 |
|
NCBI chr19:45,753,576...45,825,203
|
|
G |
Hsd17b4 |
hydroxysteroid (17-beta) dehydrogenase 4 |
multiple interactions increases expression |
ISO |
Ketoconazole promotes the reaction [Colforsin results in increased expression of HSD17B4 mRNA] Ketoconazole results in increased expression of HSD17B4 mRNA |
CTD |
PMID:16935330 |
|
NCBI chr18:45,515,427...45,604,467
|
|
G |
Hsd17b7 |
hydroxysteroid (17-beta) dehydrogenase 7 |
increases expression |
EXP |
Ketoconazole results in increased expression of HSD17B7 mRNA |
CTD |
PMID:28263823 |
|
NCBI chr13:82,170,079...82,190,018
|
|
G |
Hsd3b1 |
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of HSD3B1 mRNA |
CTD |
PMID:17229994 |
|
NCBI chr 2:186,169,864...186,175,984
|
|
G |
Hsd3b2 |
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 |
multiple interactions decreases expression |
ISO |
[Colforsin co-treated with Ketoconazole] results in decreased expression of HSD3B2 mRNA Ketoconazole results in decreased expression of HSD3B2 mRNA |
CTD |
PMID:16935330 |
|
NCBI chr 2:186,095,897...186,105,354
|
|
G |
Hspd1 |
heat shock protein family D (Hsp60) member 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of HSPD1 mRNA |
CTD |
PMID:25787151 |
|
NCBI chr 9:64,073,610...64,084,332
|
|
G |
Hyal2 |
hyaluronidase 2 |
increases expression |
ISO |
Ketoconazole results in increased expression of HYAL2 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 8:108,241,895...108,246,853
|
|
G |
Hycc1 |
hyccin PI4KA lipid kinase complex subunit 1 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of HYCC1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 4:11,132,224...11,239,120
|
|
G |
Ibsp |
integrin-binding sialoprotein |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [Calcifediol results in increased expression of IBSP mRNA] |
CTD |
PMID:21542014 |
|
NCBI chr14:5,439,825...5,452,570
|
|
G |
Id4 |
inhibitor of DNA binding 4 |
increases expression |
ISO |
Ketoconazole results in increased expression of ID4 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr17:16,389,387...16,391,956
|
|
G |
Idi1 |
isopentenyl-diphosphate delta isomerase 1 |
increases expression multiple interactions |
ISO EXP |
Ketoconazole results in increased expression of IDI1 mRNA EIF2S1 protein mutant form promotes the reaction [Ketoconazole results in increased expression of IDI1 mRNA] |
CTD |
PMID:16330322 PMID:28263823 |
|
NCBI chr17:61,629,592...61,637,357
|
|
G |
Ifih1 |
interferon induced with helicase C domain 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of IFIH1 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr 3:67,635,924...67,683,968
|
|
G |
Igfbp1 |
insulin-like growth factor binding protein 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of IGFBP1 mRNA |
CTD |
PMID:18289764 |
|
NCBI chr14:86,261,277...86,266,344
|
|
G |
Igfbp5 |
insulin-like growth factor binding protein 5 |
increases expression |
EXP |
Ketoconazole results in increased expression of IGFBP5 mRNA |
CTD |
PMID:36653537 PMID:37077353 |
|
NCBI chr 9:74,452,371...74,464,953
|
|
G |
Igfbp6 |
insulin-like growth factor binding protein 6 |
increases expression |
EXP |
Ketoconazole results in increased expression of IGFBP6 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 7:133,276,309...133,280,944
|
|
G |
Igfbp7 |
insulin-like growth factor binding protein 7 |
increases expression |
EXP |
Ketoconazole results in increased expression of IGFBP7 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr14:30,737,414...30,797,317
|
|
G |
Ighe |
immunoglobulin heavy constant epsilon |
multiple interactions |
ISO |
Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [IL4 protein results in increased expression of IGHE mRNA alternative form]]; Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [IL4 protein results in increased expression of IGHE mRNA]]; Ketoconazole inhibits the reaction [IL4 protein results in increased expression of IGHE mRNA alternative form]; Ketoconazole inhibits the reaction [IL4 protein results in increased expression of IGHE mRNA] |
CTD |
PMID:12230500 |
|
|
|
G |
Igkc |
immunoglobulin kappa constant |
decreases expression |
EXP |
Ketoconazole results in decreased expression of IGKC mRNA |
CTD |
PMID:18289764 |
|
|
|
G |
Igsf10 |
immunoglobulin superfamily, member 10 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of IGSF10 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 2:143,575,710...143,605,044
|
|
G |
Ihh |
Indian hedgehog signaling molecule |
increases expression |
EXP |
Ketoconazole results in increased expression of IHH mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 9:76,504,315...76,510,532
|
|
G |
Il1a |
interleukin 1 alpha |
increases expression |
ISO |
Ketoconazole results in increased expression of IL1A mRNA |
CTD |
PMID:32816093 |
|
NCBI chr 3:136,979,804...136,990,236
|
|
G |
Il1b |
interleukin 1 beta |
multiple interactions increases expression |
ISO EXP |
Ketoconazole inhibits the reaction [[IL1B protein co-treated with IL6 protein] results in increased expression of SAA1 mRNA]; Ketoconazole inhibits the reaction [[IL1B protein co-treated with IL6 protein] results in increased expression of SAA2 mRNA]; Ketoconazole promotes the reaction [gelsemine results in increased expression of IL1B protein] Ketoconazole results in increased expression of IL1B mRNA Ketoconazole inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B protein] |
CTD |
PMID:17966066 PMID:28138970 PMID:31168027 PMID:32816093 PMID:34627953 |
|
NCBI chr 3:137,030,200...137,036,581
|
|
G |
Il1rl1 |
interleukin 1 receptor-like 1 |
multiple interactions |
ISO |
Ketoconazole promotes the reaction [Calcitriol results in increased expression of IL1RL1 mRNA] |
CTD |
PMID:12040012 |
|
NCBI chr 9:42,661,694...42,727,266
|
|
G |
Il24 |
interleukin 24 |
increases expression |
ISO |
Ketoconazole results in increased expression of IL24 mRNA |
CTD |
PMID:32816093 |
|
NCBI chr13:44,905,362...44,910,760
|
|
G |
Il33 |
interleukin 33 |
affects expression increases expression |
EXP |
Ketoconazole affects the expression of IL33 mRNA Ketoconazole results in increased expression of IL33 mRNA |
CTD |
PMID:18355885 PMID:37077353 |
|
NCBI chr 1:227,701,964...227,736,374
|
|
G |
Il4 |
interleukin 4 |
multiple interactions decreases secretion decreases expression |
ISO |
1-Methyl-3-isobutylxanthine inhibits the reaction [Ketoconazole results in decreased expression of IL4 mRNA]; 1-Methyl-3-isobutylxanthine inhibits the reaction [Ketoconazole results in decreased secretion of IL4 protein]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [IL4 protein results in increased expression of IGHE mRNA alternative form]]; Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [IL4 protein results in increased expression of IGHE mRNA]]; Bucladesine inhibits the reaction [Ketoconazole results in decreased expression of IL4 mRNA]; Bucladesine inhibits the reaction [Ketoconazole results in decreased secretion of IL4 protein]; Colforsin inhibits the reaction [Ketoconazole results in decreased expression of IL4 mRNA]; Colforsin inhibits the reaction [Ketoconazole results in decreased secretion of IL4 protein]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2]; Ketoconazole inhibits the reaction [IL4 protein results in increased chemical synthesis of Cyclic AMP]; Ketoconazole inhibits the reaction [IL4 protein results in increased expression of IGHE mRNA alternative form]; Ketoconazole inhibits the reaction [IL4 protein results in increased expression of IGHE mRNA]; Ketoconazole promotes the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprostone] |
CTD |
PMID:11886533 PMID:12230500 PMID:15284827 PMID:23688403 |
|
NCBI chr10:38,272,003...38,277,549
|
|
G |
Il5 |
interleukin 5 |
multiple interactions decreases expression decreases secretion |
ISO |
1-Methyl-3-isobutylxanthine inhibits the reaction [Ketoconazole results in decreased expression of IL5 mRNA]; 1-Methyl-3-isobutylxanthine inhibits the reaction [Ketoconazole results in decreased secretion of IL5 protein]; Bucladesine inhibits the reaction [Ketoconazole results in decreased expression of IL5 mRNA]; Bucladesine inhibits the reaction [Ketoconazole results in decreased secretion of IL5 protein]; Colforsin inhibits the reaction [Ketoconazole results in decreased expression of IL5 mRNA]; Colforsin inhibits the reaction [Ketoconazole results in decreased secretion of IL5 protein] |
CTD |
PMID:11886533 PMID:15284827 |
|
NCBI chr10:38,375,132...38,378,003
|
|
G |
Il6 |
interleukin 6 |
multiple interactions |
ISO EXP |
Ketoconazole inhibits the reaction [[IL1B protein co-treated with IL6 protein] results in increased expression of SAA1 mRNA]; Ketoconazole inhibits the reaction [[IL1B protein co-treated with IL6 protein] results in increased expression of SAA2 mRNA]; Ketoconazole inhibits the reaction [IL6 protein results in increased expression of HAMP mRNA] Ketoconazole inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein] |
CTD |
PMID:17966066 PMID:31168027 |
|
NCBI chr 4:5,889,999...5,894,575
|
|
G |
Ing1 |
inhibitor of growth family, member 1 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of ING1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr16:77,937,276...77,945,320
|
|
G |
Ing2 |
inhibitor of growth family, member 2 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of ING2 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr16:51,305,311...51,316,177
|
|
G |
Inhbe |
inhibin subunit beta E |
increases expression |
ISO |
Ketoconazole results in increased expression of INHBE mRNA |
CTD |
PMID:15342952 PMID:17175557 PMID:17567588 |
|
NCBI chr 7:65,061,531...65,064,519
|
|
G |
Inip |
INTS3 and NABP interacting protein |
increases expression |
EXP |
Ketoconazole results in increased expression of INIP mRNA |
CTD |
PMID:36653537 |
|
NCBI chr 5:74,648,392...74,662,628
|
|
G |
Insig1 |
insulin induced gene 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of INSIG1 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 4:8,049,339...8,057,812
|
|
G |
Insl3 |
insulin-like 3 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of INSL3 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr16:18,398,682...18,400,566
|
|
G |
Insr |
insulin receptor |
decreases expression |
EXP |
Ketoconazole results in decreased expression of INSR mRNA |
CTD |
PMID:37077353 |
|
NCBI chr12:5,991,135...6,129,275
|
|
G |
Ipo5 |
importin 5 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of IPO5 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr15:104,397,626...104,447,985
|
|
G |
Ipo7 |
importin 7 |
increases expression |
ISO |
Ketoconazole results in increased expression of IPO7 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 1:173,497,472...173,537,707
|
|
G |
Irs1 |
insulin receptor substrate 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of IRS1 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 9:91,001,137...91,053,959
|
|
G |
Itpr1 |
inositol 1,4,5-trisphosphate receptor, type 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of ITPR1 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 4:142,743,401...143,066,505
|
|
G |
Ivd |
isovaleryl-CoA dehydrogenase |
increases expression |
EXP |
Ketoconazole results in increased expression of IVD mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 3:105,851,710...105,872,144
|
|
G |
Kcmf1 |
potassium channel modulatory factor 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of KCMF1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 4:106,447,974...106,508,359
|
|
G |
Kcna5 |
potassium voltage-gated channel subfamily A member 5 |
decreases activity |
ISO |
Ketoconazole results in decreased activity of KCNA5 protein |
CTD |
PMID:9694927 |
|
NCBI chr 4:161,040,853...161,044,311
|
|
G |
Kcne2 |
potassium voltage-gated channel subfamily E regulatory subunit 2 |
increases expression |
EXP |
Ketoconazole results in increased expression of KCNE2 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr11:45,003,468...45,015,942
|
|
G |
Kcnh1 |
potassium voltage-gated channel subfamily H member 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of KCNH1 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr13:103,722,140...104,024,762
|
|
G |
Kcnh2 |
potassium voltage-gated channel subfamily H member 2 |
affects activity affects localization decreases activity multiple interactions decreases response to substance |
ISO |
Ketoconazole affects the activity of KCNH2 protein mutant form Ketoconazole affects the localization of KCNH2; Ketoconazole affects the localization of KCNH2 protein mutant form Ketoconazole results in decreased activity of KCNH2; Ketoconazole results in decreased activity of KCNH2 protein [Ketoconazole co-treated with desloratadine co-treated with Loratadine] results in decreased activity of KCNH2 protein; [Ketoconazole co-treated with desloratadine] results in decreased activity of KCNH2 protein; [Ketoconazole co-treated with Loratadine] results in decreased activity of KCNH2 protein; Ketoconazole binds to and results in decreased activity of KCNH2 protein; Terfenadine promotes the reaction [Ketoconazole results in decreased activity of KCNH2 protein] KCNH2 protein mutant form results in decreased susceptibility to Ketoconazole |
CTD |
PMID:9694927 PMID:15272206 PMID:16542653 PMID:17965736 PMID:24052561 PMID:29143966 More...
|
|
NCBI chr 4:11,719,357...11,751,424
|
|
G |
Kctd12 |
potassium channel tetramerization domain containing 12 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of KCTD12 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr15:86,214,786...86,220,725
|
|
G |
Kctd12b |
potassium channel tetramerization domain containing 12b |
decreases expression |
EXP |
Ketoconazole results in decreased expression of KCTD12B mRNA |
CTD |
PMID:37077353 |
|
NCBI chr X:17,643,707...17,654,820
|
|
G |
Kdm2b |
lysine demethylase 2B |
affects expression |
ISO |
Ketoconazole affects the expression of KDM2B mRNA |
CTD |
PMID:36621641 |
|
NCBI chr12:39,224,422...39,362,126
|
|
G |
Kdm3a |
lysine demethylase 3A |
increases expression |
EXP |
Ketoconazole results in increased expression of KDM3A mRNA |
CTD |
PMID:36653537 |
|
NCBI chr 4:103,630,907...103,675,073
|
|
G |
Keap1 |
Kelch-like ECH-associated protein 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of KEAP1 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 8:19,768,375...19,777,862
|
|
G |
Klf11 |
KLF transcription factor 11 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of KLF11 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 6:41,285,699...41,297,548
|
|
G |
Klk1 |
kallikrein 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of KLK1 mRNA |
CTD |
PMID:31099283 |
|
NCBI chr 1:94,642,644...94,646,760
|
|
G |
Klk1c10 |
kallikrein 1-related peptidase C10 |
multiple interactions |
ISO |
[Goserelin co-treated with Dutasteride co-treated with bicalutamide co-treated with Ketoconazole] results in decreased expression of KLK3 protein |
CTD |
PMID:24323034 |
|
NCBI chr 1:94,402,993...94,407,052
|
|
G |
Klk6 |
kallikrein related-peptidase 6 |
multiple interactions increases expression |
ISO EXP |
Ketoconazole promotes the reaction [Calcitriol results in increased expression of KLK6 mRNA] Ketoconazole results in increased expression of KLK6 mRNA |
CTD |
PMID:26485663 PMID:37077353 |
|
NCBI chr 1:94,278,863...94,286,136
|
|
G |
Kpna3 |
karyopherin subunit alpha 3 |
increases expression |
ISO |
Ketoconazole results in increased expression of KPNA3 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr15:39,712,375...39,786,127
|
|
G |
Lamb3 |
laminin subunit beta 3 |
increases expression |
EXP |
Ketoconazole results in increased expression of LAMB3 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr13:104,833,810...104,875,405
|
|
G |
Laptm4a |
lysosomal protein transmembrane 4 alpha |
increases expression |
EXP |
Ketoconazole results in increased expression of LAPTM4A mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 6:31,719,287...31,737,023
|
|
G |
Lcn2 |
lipocalin 2 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of LCN2 mRNA |
CTD |
PMID:18289764 |
|
NCBI chr 3:36,078,432...36,081,851
|
|
G |
Lhb |
luteinizing hormone subunit beta |
multiple interactions |
EXP |
Ketoconazole inhibits the reaction [LHB protein results in increased abundance of Testosterone] |
CTD |
PMID:7589908 |
|
NCBI chr 1:105,037,457...105,038,446
|
|
G |
Lhcgr |
luteinizing hormone/choriogonadotropin receptor |
decreases expression |
EXP |
Ketoconazole results in decreased expression of LHCGR mRNA |
CTD |
PMID:36653537 |
|
NCBI chr 6:5,661,871...5,728,109
|
|
G |
Lhpp |
phospholysine phosphohistidine inorganic pyrophosphate phosphatase |
increases expression |
EXP |
Ketoconazole results in increased expression of LHPP mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 1:187,403,390...187,494,577
|
|
G |
Lhx1 |
LIM homeobox 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of LHX1 mRNA |
CTD |
PMID:28263823 |
|
NCBI chr10:69,396,829...69,403,617
|
|
G |
Lmnb1 |
lamin B1 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of LMNB1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr18:52,373,939...52,413,284
|
|
G |
Lnpk |
lunapark, ER junction formation factor |
increases expression |
ISO |
Ketoconazole results in increased expression of LNPK mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 3:59,418,872...59,487,029
|
|
G |
Lox |
lysyl oxidase |
affects expression |
EXP |
Ketoconazole affects the expression of LOX mRNA |
CTD |
PMID:18355885 |
|
NCBI chr18:45,964,544...45,977,431
|
|
G |
Lrrc17 |
leucine rich repeat containing 17 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of LRRC17 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 4:13,501,428...13,531,845
|
|
G |
Lrrc28 |
leucine rich repeat containing 28 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of LRRC28 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr 1:121,116,833...121,245,805
|
|
G |
Lrrc41 |
leucine rich repeat containing 41 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of LRRC41 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 5:129,554,547...129,575,450
|
|
G |
Lrrc75a |
leucine rich repeat containing 75A |
increases expression |
EXP |
Ketoconazole results in increased expression of LRRC75A mRNA |
CTD |
PMID:28263823 |
|
NCBI chr10:47,298,222...47,343,301
|
|
G |
Lrrfip2 |
LRR binding FLII interacting protein 2 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of LRRFIP2 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 8:111,091,453...111,193,947
|
|
G |
Lsm5 |
LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated |
increases expression |
ISO |
Ketoconazole results in increased expression of LSM5 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 4:85,951,073...85,954,289
|
|
G |
Lss |
lanosterol synthase |
increases expression |
ISO |
Ketoconazole results in increased expression of LSS mRNA |
CTD |
PMID:15342952 PMID:17175557 PMID:17567588 |
|
NCBI chr20:12,090,641...12,118,230
|
|
G |
M6pr |
mannose-6-phosphate receptor, cation dependent |
decreases expression |
ISO |
Ketoconazole results in decreased expression of M6PR mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 4:155,501,080...155,510,219
|
|
G |
Macroh2a1 |
macroH2A.1 histone |
affects expression |
EXP |
Ketoconazole affects the expression of MACROH2A1 mRNA |
CTD |
PMID:18355885 |
|
NCBI chr17:8,479,331...8,542,071
|
|
G |
Madcam1 |
mucosal vascular addressin cell adhesion molecule 1 |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [TNF protein results in increased expression of MADCAM1 protein] |
CTD |
PMID:12388057 |
|
NCBI chr 7:10,036,301...10,039,703
|
|
G |
Malsu1 |
mitochondrial assembly of ribosomal large subunit 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of MALSU1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 4:78,051,090...78,059,913
|
|
G |
Manba |
mannosidase beta |
affects expression |
EXP |
Ketoconazole affects the expression of MANBA mRNA |
CTD |
PMID:18355885 |
|
NCBI chr 2:223,910,432...224,002,988
|
|
G |
Map4k5 |
mitogen-activated protein kinase kinase kinase kinase 5 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of MAP4K5 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 6:94,020,079...94,112,943
|
|
G |
Mapk14 |
mitogen activated protein kinase 14 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of MAPK14 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr20:6,751,288...6,812,294
|
|
G |
Mapk8 |
mitogen-activated protein kinase 8 |
increases phosphorylation increases expression |
ISO EXP |
Ketoconazole results in increased phosphorylation of MAPK8 protein Ketoconazole results in increased expression of MAPK8 mRNA |
CTD |
PMID:19631732 PMID:25787151 |
|
NCBI chr16:8,645,171...8,728,225
|
|
G |
Mbnl1 |
muscleblind-like splicing regulator 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of MBNL1 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 2:144,639,819...144,814,395
|
|
G |
Mc3r |
melanocortin 3 receptor |
decreases expression |
EXP |
Ketoconazole results in decreased expression of MC3R mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 3:161,016,347...161,017,444
|
|
G |
Mcl1 |
MCL1 apoptosis regulator, BCL2 family member |
multiple interactions |
ISO |
[Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of MCL1 protein |
CTD |
PMID:31629065 |
|
NCBI chr 2:185,884,840...185,912,532
|
|
G |
Mcm7 |
minichromosome maintenance complex component 7 |
increases expression |
EXP |
Ketoconazole results in increased expression of MCM7 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr12:22,155,921...22,163,320
|
|
G |
Mdh1 |
malate dehydrogenase 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of MDH1 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr14:95,630,625...95,645,920
|
|
G |
Me1 |
malic enzyme 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of ME1 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 8:96,429,057...96,540,244
|
|
G |
Met |
MET proto-oncogene, receptor tyrosine kinase |
increases expression |
ISO |
Ketoconazole results in increased expression of MET mRNA |
CTD |
PMID:32816093 |
|
NCBI chr 4:46,756,823...46,864,041
|
|
G |
Mfn1 |
mitofusin 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of MFN1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 2:115,313,380...115,359,651
|
|
G |
Mgll |
monoglyceride lipase |
increases expression |
EXP |
Ketoconazole results in increased expression of MGLL mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 4:122,749,436...122,851,440
|
|
G |
Mgp |
matrix Gla protein |
affects expression |
EXP |
Ketoconazole affects the expression of MGP mRNA |
CTD |
PMID:18289764 |
|
NCBI chr 4:171,497,472...171,500,888
|
|
G |
Mgst1 |
microsomal glutathione S-transferase 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of MGST1 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 4:171,029,666...171,044,893
|
|
G |
Mgst2 |
microsomal glutathione S-transferase 2 |
increases expression |
ISO |
Ketoconazole results in increased expression of MGST2 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 2:135,679,524...135,715,828
|
|
G |
Micb |
MHC class I polypeptide-related sequence B |
increases expression |
ISO |
Ketoconazole results in increased expression of MICB mRNA |
CTD |
PMID:32060585 |
|
NCBI chr 1:78,495,779...78,513,030
|
|
G |
Micu1 |
mitochondrial calcium uptake 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of MICU1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr20:28,211,774...28,357,928
|
|
G |
Mill1 |
MHC I like leukocyte 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of MICA mRNA |
CTD |
PMID:32060585 |
|
NCBI chr 1:78,372,798...78,398,932
|
|
G |
Mki67 |
marker of proliferation Ki-67 |
increases expression |
ISO |
Ketoconazole results in increased expression of MKI67 mRNA |
CTD |
PMID:25808816 |
|
NCBI chr 1:199,926,150...199,952,847
|
|
G |
Mkrn3 |
makorin, ring finger protein, 3 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of MKRN3 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 1:115,926,774...115,929,288
|
|
G |
Mlx |
MAX dimerization protein MLX |
affects expression |
EXP |
Ketoconazole affects the expression of MLX mRNA |
CTD |
PMID:18355885 |
|
NCBI chr10:86,519,517...86,524,607
|
|
G |
Mlycd |
malonyl-CoA decarboxylase |
increases expression |
EXP |
Ketoconazole results in increased expression of MLYCD mRNA |
CTD |
PMID:37077353 |
|
NCBI chr19:64,356,582...64,372,447
|
|
G |
Mmab |
metabolism of cobalamin associated B |
increases expression |
ISO |
Ketoconazole results in increased expression of MMAB mRNA |
CTD |
PMID:36621641 |
|
NCBI chr12:47,819,757...47,833,127
|
|
G |
Mmp14 |
matrix metallopeptidase 14 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of MMP14 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr15:27,887,795...27,897,020
|
|
G |
Mpzl1 |
myelin protein zero-like 1 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of MPZL1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr13:77,852,467...77,889,305
|
|
G |
Mrap2 |
melanocortin 2 receptor accessory protein 2 |
increases expression |
EXP |
Ketoconazole results in increased expression of MRAP2 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr 8:96,968,239...97,024,581
|
|
G |
Mras |
muscle RAS oncogene homolog |
increases expression |
ISO |
Ketoconazole results in increased expression of MRAS mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 8:99,944,036...100,006,771
|
|
G |
Mrpl11 |
mitochondrial ribosomal protein L11 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of MRPL11 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 1:211,693,807...211,696,667
|
|
G |
Mrpl18 |
mitochondrial ribosomal protein L18 |
increases expression |
ISO |
Ketoconazole results in increased expression of MRPL18 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 1:47,837,169...47,841,987
|
|
G |
Mrpl32 |
mitochondrial ribosomal protein L32 |
increases expression |
ISO |
Ketoconazole results in increased expression of MRPL32 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr17:50,565,133...50,568,000
|
|
G |
Mrps18b |
mitochondrial ribosomal protein S18B |
affects expression |
EXP |
Ketoconazole affects the expression of MRPS18B mRNA |
CTD |
PMID:18355885 |
|
NCBI chr20:2,842,978...2,849,065
|
|
G |
Mrps30 |
mitochondrial ribosomal protein S30 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of MRPS30 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 2:50,456,253...50,463,128
|
|
G |
Mrps31 |
mitochondrial ribosomal protein S31 |
increases expression |
ISO |
Ketoconazole results in increased expression of MRPS31 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr16:69,601,349...69,621,609
|
|
G |
Mrto4 |
MRT4 homolog, ribosome maturation factor |
increases expression |
EXP |
Ketoconazole results in increased expression of MRTO4 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 5:151,601,780...151,608,533
|
|
G |
Msmo1 |
methylsterol monooxygenase 1 |
affects expression multiple interactions increases expression |
EXP ISO |
Ketoconazole affects the expression of MSMO1 mRNA EIF2S1 protein mutant form promotes the reaction [Ketoconazole results in increased expression of MSMO1 mRNA] |
CTD |
PMID:16330322 PMID:18355885 |
|
NCBI chr16:24,980,680...24,997,927
|
|
G |
Msn |
moesin |
increases expression |
EXP |
Ketoconazole results in increased expression of MSN mRNA |
CTD |
PMID:36653537 |
|
NCBI chr X:60,996,043...61,064,011
|
|
G |
Mt1 |
metallothionein 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of MT1A mRNA |
CTD |
PMID:18289764 |
|
NCBI chr19:10,831,959...10,832,975
|
|
G |
Mtch2 |
mitochondrial carrier 2 |
increases expression |
ISO |
Ketoconazole results in increased expression of MTCH2 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 3:76,830,549...76,850,189
|
|
G |
Mthfd1l |
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like |
decreases expression |
ISO |
Ketoconazole results in decreased expression of MTHFD1L mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 1:40,443,926...40,632,911
|
|
G |
Mtmr2 |
myotubularin related protein 2 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of MTMR2 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 8:10,617,993...10,670,724
|
|
G |
Mvd |
mevalonate diphosphate decarboxylase |
increases expression |
EXP |
Ketoconazole results in increased expression of MVD mRNA |
CTD |
PMID:37077353 |
|
NCBI chr19:50,496,366...50,506,429
|
|
G |
Myd88 |
MYD88, innate immune signal transduction adaptor |
increases expression |
EXP |
Ketoconazole results in increased expression of MYD88 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 8:127,952,161...127,956,230
|
|
G |
Myh14 |
myosin heavy chain 14 |
increases expression |
EXP |
Ketoconazole results in increased expression of MYH14 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 1:95,096,266...95,158,861
|
|
G |
Myh7 |
myosin heavy chain 7 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of MYH7 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr15:32,416,525...32,439,851
|
|
G |
Myt1 |
myelin transcription factor 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of MYT1 mRNA |
CTD |
PMID:31099283 |
|
NCBI chr 3:168,890,466...168,950,341
|
|
G |
Nasp |
nuclear autoantigenic sperm protein |
increases expression |
ISO |
Ketoconazole results in increased expression of NASP mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 5:135,294,599...135,319,992
|
|
G |
Ncbp2as2 |
NCBP2 antisense 2 (head to head) |
increases expression |
ISO |
Ketoconazole results in increased expression of NCBP2AS2 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr11:68,829,950...68,830,715
|
|
G |
Ncf1 |
neutrophil cytosolic factor 1 |
decreases expression increases expression |
EXP |
Ketoconazole results in decreased expression of NCF1 mRNA Ketoconazole results in increased expression of NCF1 mRNA |
CTD |
PMID:25787151 PMID:37077353 |
|
NCBI chr12:28,121,816...28,131,080
|
|
G |
Ncoa1 |
nuclear receptor coactivator 1 |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NR1H4 protein binds to NCOA1 protein]]; Ketoconazole inhibits the reaction [NR1I2 protein binds to NCOA1 protein]; Ketoconazole inhibits the reaction [Paclitaxel promotes the reaction [NR1I2 protein binds to NCOA1 protein]]; Ketoconazole inhibits the reaction [piperine promotes the reaction [NCOA1 protein binds to NR1I2 protein]]; Ketoconazole inhibits the reaction [Rifampin promotes the reaction [NR1I2 protein binds to NCOA1 protein]] |
CTD |
PMID:12072427 PMID:16819505 PMID:17438109 PMID:17998298 PMID:23525103 PMID:23707768 More...
|
|
NCBI chr 6:32,952,090...33,229,829
|
|
G |
Ncor2 |
nuclear receptor co-repressor 2 |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [NCOR2 protein binds to NR1I2 protein]; Ketoconazole inhibits the reaction [NR1I2 protein binds to NCOR2 protein] |
CTD |
PMID:12072427 PMID:29356861 |
|
NCBI chr12:37,127,736...37,289,612
|
|
G |
Ncr3lg1 |
natural killer cell cytotoxicity receptor 3 ligand 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of NCR3LG1 mRNA; Ketoconazole results in increased expression of NCR3LG1 protein |
CTD |
PMID:32060585 |
|
NCBI chr 1:96,565,664...96,581,825
|
|
G |
Ndrg1 |
N-myc downstream regulated 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of NDRG1 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 7:100,573,526...100,614,902
|
|
G |
Ndufa5 |
NADH:ubiquinone oxidoreductase subunit A5 |
increases expression |
EXP |
Ketoconazole results in increased expression of NDUFA5 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 4:53,962,877...53,971,235
|
|
G |
Neil2 |
nei-like DNA glycosylase 2 |
increases expression |
ISO |
Ketoconazole results in increased expression of NEIL2 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr15:37,444,676...37,454,863
|
|
G |
Net1 |
neuroepithelial cell transforming 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of NET1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr17:71,251,145...71,280,345
|
|
G |
Neto1 |
neuropilin and tolloid like 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of NETO1 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr18:79,635,633...79,753,913
|
|
G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions increases expression |
ISO EXP |
[Ketoconazole results in increased activity of AHR protein] which results in increased activity of and results in increased localization of NFE2L2 protein; NFE2L2 protein promotes the reaction [Ketoconazole inhibits the reaction [Benzo(a)pyrene results in increased abundance of Reactive Oxygen Species]]; NFE2L2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]]; NFE2L2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]] Ketoconazole results in increased expression of NFE2L2 mRNA; Ketoconazole results in increased expression of NFE2L2 protein [Ketoconazole co-treated with Carbon Tetrachloride] results in increased expression of NFE2L2 protein |
CTD |
PMID:21753779 PMID:31168027 PMID:37077353 |
|
NCBI chr 3:81,001,529...81,031,165
|
|
G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein] |
CTD |
PMID:23688403 |
|
NCBI chr 6:78,593,844...78,597,307
|
|
G |
Ngfr |
nerve growth factor receptor |
increases expression |
EXP |
Ketoconazole results in increased expression of NGFR mRNA |
CTD |
PMID:28263823 |
|
NCBI chr10:81,012,077...81,030,305
|
|
G |
Niban1 |
niban apoptosis regulator 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of NIBAN1 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr13:63,674,240...63,827,748
|
|
G |
Niban2 |
niban apoptosis regulator 2 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of NIBAN2 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 3:16,174,674...16,224,293
|
|
G |
Ninj1 |
ninjurin 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of NINJ1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr17:15,659,208...15,668,115
|
|
G |
Nlrp3 |
NLR family, pyrin domain containing 3 |
increases expression |
ISO |
Ketoconazole results in increased expression of NLRP3 mRNA |
CTD |
PMID:28138970 |
|
NCBI chr10:44,826,299...44,853,373
|
|
G |
Nos3 |
nitric oxide synthase 3 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of NOS3 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 4:11,686,088...11,706,604
|
|
G |
Npm2 |
nucleophosmin/nucleoplasmin 2 |
increases expression |
EXP |
Ketoconazole results in increased expression of NPM2 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr15:45,722,282...45,729,336
|
|
G |
Npr3 |
natriuretic peptide receptor 3 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of NPR3 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 2:60,865,483...60,933,432
|
|
G |
Npw |
neuropeptide W |
decreases expression |
EXP |
Ketoconazole results in decreased expression of NPW mRNA |
CTD |
PMID:37077353 |
|
NCBI chr10:13,680,275...13,681,618
|
|
G |
Npy2r |
neuropeptide Y receptor Y2 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of NPY2R mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 2:167,901,999...167,912,165
|
|
G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases expression multiple interactions |
ISO EXP |
Ketoconazole results in increased expression of NQO1 mRNA; Ketoconazole results in increased expression of NQO1 protein AHR promotes the reaction [Ketoconazole results in increased expression of NQO1 mRNA]; AHR promotes the reaction [Ketoconazole results in increased expression of NQO1 protein]; Dactinomycin inhibits the reaction [Ketoconazole results in increased expression of NQO1 mRNA] [Ketoconazole co-treated with Carbon Tetrachloride] results in increased expression of NQO1 mRNA |
CTD |
PMID:17923278 PMID:21753779 PMID:31168027 |
|
NCBI chr19:52,205,374...52,220,267
|
|
G |
Nr0b2 |
nuclear receptor subfamily 0, group B, member 2 |
increases expression |
ISO |
Ketoconazole results in increased expression of NR0B2 mRNA |
CTD |
PMID:15342952 PMID:17175557 |
|
NCBI chr 5:145,779,294...145,782,609
|
|
G |
Nr1d1 |
nuclear receptor subfamily 1, group D, member 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of NR1D1 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr10:84,224,599...84,231,812
|
|
G |
Nr1h2 |
nuclear receptor subfamily 1, group H, member 2 |
multiple interactions increases expression |
ISO EXP |
Ketoconazole inhibits the reaction [T0901317 results in increased activity of NR1H2 protein] Ketoconazole results in increased expression of NR1H2 mRNA |
CTD |
PMID:16819505 PMID:37077353 |
|
NCBI chr 1:95,041,967...95,047,358
|
|
G |
Nr1h3 |
nuclear receptor subfamily 1, group H, member 3 |
multiple interactions |
EXP ISO |
Ketoconazole inhibits the reaction [Clofibrate results in increased expression of NR1H3 mRNA] Ketoconazole inhibits the reaction [T0901317 results in increased activity of NR1H3 protein] |
CTD |
PMID:14690017 PMID:16819505 |
|
NCBI chr 3:97,614,616...97,632,053
|
|
G |
Nr1h4 |
nuclear receptor subfamily 1, group H, member 4 |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NR1H4 protein binds to NCOA1 protein]]; Ketoconazole inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein] |
CTD |
PMID:16819505 |
|
NCBI chr 7:25,733,471...25,829,440
|
|
G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
multiple interactions increases activity decreases expression decreases response to substance |
ISO |
[Ketoconazole co-treated with Rifampin] results in increased activity of NR1I2 protein; Ketoconazole binds to and results in decreased activity of NR1I2 protein; Ketoconazole inhibits the reaction [Corticosterone promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]; Ketoconazole inhibits the reaction [NCOR2 protein binds to NR1I2 protein]; Ketoconazole inhibits the reaction [NR1I2 protein binds to NCOA1 protein]; Ketoconazole inhibits the reaction [NR1I2 protein binds to NCOR2 protein]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [piperine results in increased expression of ABCB1 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [piperine results in increased expression of ABCB1 protein]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [piperine results in increased expression of CYP3A4 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [piperine results in increased expression of CYP3A4 protein]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of ABCB1 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of ABCB1 protein]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 protein]]; Ketoconazole inhibits the reaction [NR1I2 protein results in decreased uptake of and results in decreased metabolism of Glucose]; Ketoconazole inhibits the reaction [Paclitaxel promotes the reaction [NR1I2 protein binds to NCOA1 protein]]; Ketoconazole inhibits the reaction [Paclitaxel results in increased activity of NR1I2 protein]; Ketoconazole inhibits the reaction [piperine promotes the reaction [NCOA1 protein binds to NR1I2 protein]]; Ketoconazole inhibits the reaction [Rifampin binds to and results in increased activity of NR1I2 protein]; Ketoconazole inhibits the reaction [Rifampin promotes the reaction [NR1I2 protein binds to NCOA1 protein]]; Ketoconazole inhibits the reaction [Rifampin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]; Ketoconazole inhibits the reaction [Rifampin results in increased activity of NR1I2 protein] Ketoconazole results in increased activity of NR1I2 protein Ketoconazole results in decreased expression of NR1I2 mRNA; Ketoconazole results in decreased expression of NR1I2 protein Ketoconazole inhibits the reaction [Pregnenolone Carbonitrile results in increased activity of NR1I2 protein] NR1I2 protein mutant form results in decreased susceptibility to Ketoconazole |
CTD |
PMID:12072427 PMID:16608920 PMID:16819505 PMID:17438109 PMID:17998298 PMID:20869355 PMID:21402137 PMID:23525103 PMID:23707768 PMID:25343516 PMID:25680588 PMID:26616219 PMID:29356861 PMID:36893891 More...
|
|
NCBI chr11:75,965,717...76,006,733
|
|
G |
Nr1i3 |
nuclear receptor subfamily 1, group I, member 3 |
multiple interactions decreases activity decreases expression |
ISO |
[Ketoconazole co-treated with PK 11195] results in decreased activity of NR1I3 protein alternative form; Ketoconazole binds to and results in decreased activity of NR1I3 protein alternative form; Ketoconazole inhibits the reaction [Dexamethasone results in increased expression of NR1I3 mRNA]; Ketoconazole inhibits the reaction [Phenobarbital results in increased activity of NR1I3 protein] Ketoconazole results in decreased activity of NR1I3 protein Ketoconazole results in decreased expression of NR1I3 mRNA Ketoconazole inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased activity of NR1I3 protein] |
CTD |
PMID:16608920 PMID:16819505 PMID:20869355 |
|
NCBI chr13:86,165,327...86,170,362
|
|
G |
Nr2f1 |
nuclear receptor subfamily 2, group F, member 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of NR2F1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 2:8,040,375...8,050,123
|
|
G |
Nr3c1 |
nuclear receptor subfamily 3, group C, member 1 |
affects binding decreases activity multiple interactions |
ISO |
Ketoconazole binds to NR3C1 protein Ketoconazole results in decreased activity of NR3C1 protein Ketoconazole inhibits the reaction [Dexamethasone binds to and results in increased activity of NR3C1 protein] |
CTD |
PMID:15755314 PMID:16608920 PMID:25000292 |
|
NCBI chr18:31,522,783...31,644,508
|
|
G |
Nr5a1 |
nuclear receptor subfamily 5, group A, member 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of NR5A1 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 3:22,464,786...22,486,328
|
|
G |
Nrep |
neuronal regeneration related protein |
affects expression |
EXP |
Ketoconazole affects the expression of NREP mRNA |
CTD |
PMID:18355885 |
|
NCBI chr18:25,291,219...25,320,742
|
|
G |
Nrip3 |
nuclear receptor interacting protein 3 |
increases expression |
EXP |
Ketoconazole results in increased expression of NRIP3 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr 1:173,224,532...173,249,829
|
|
G |
Nsdhl |
NAD(P) dependent 3-beta-hydroxysteroid dehydrogenase NSDHL |
increases expression |
EXP |
Ketoconazole results in increased expression of NSDHL mRNA |
CTD |
PMID:28263823 |
|
NCBI chr X:155,817,301...155,848,224
|
|
G |
Nsmf |
NMDA receptor synaptonuclear signaling and neuronal migration factor |
increases expression |
EXP |
Ketoconazole results in increased expression of NSMF mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 3:28,260,018...28,268,790
|
|
G |
Ntng1 |
netrin G1 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of NTNG1 mRNA |
CTD |
PMID:31099283 |
|
NCBI chr 2:197,462,785...197,827,681
|
|
G |
Nub1 |
negative regulator of ubiquitin-like proteins 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of NUB1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 4:10,442,917...10,473,689
|
|
G |
Nudt4 |
nudix hydrolase 4 |
increases expression |
ISO |
Ketoconazole results in increased expression of NUDT4 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 7:32,074,978...32,091,491
|
|
G |
Nup214 |
nucleoporin 214 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of NUP214 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr 3:35,652,841...35,738,323
|
|
G |
Nup62 |
nucleoporin 62 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of NUP62 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr 1:95,298,995...95,314,902
|
|
G |
Nupr1 |
nuclear protein 1, transcriptional regulator |
increases expression |
ISO |
Ketoconazole results in increased expression of NUPR1 mRNA |
CTD |
PMID:15342952 PMID:17175557 PMID:17567588 |
|
NCBI chr 1:190,643,866...190,645,901
|
|
G |
Oaf |
out at first homolog |
affects expression |
EXP |
Ketoconazole affects the expression of OAF mRNA |
CTD |
PMID:18355885 |
|
NCBI chr 8:43,594,362...43,612,334
|
|
G |
Ociad1 |
OCIA domain containing 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of OCIAD1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr14:34,897,851...34,915,291
|
|
G |
Odc1 |
ornithine decarboxylase 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of ODC1 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 6:46,058,439...46,065,148
|
|
G |
Osbpl8 |
oxysterol binding protein-like 8 |
increases expression |
ISO |
Ketoconazole results in increased expression of OSBPL8 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 7:46,596,944...46,749,888
|
|
G |
Ovol1 |
ovo like transcriptional repressor 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of OVOL1 mRNA; Ketoconazole results in increased expression of OVOL1 protein |
CTD |
PMID:26873447 |
|
NCBI chr 1:202,855,261...202,868,858
|
|
G |
Oxt |
oxytocin/neurophysin I prepropeptide |
increases expression |
EXP |
Ketoconazole results in increased expression of OXT mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 3:117,782,650...117,783,490
|
|
G |
Pacs1 |
phosphofurin acidic cluster sorting protein 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of PACS1 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 1:202,437,503...202,569,473
|
|
G |
Palld |
palladin, cytoskeletal associated protein |
decreases expression |
ISO |
Ketoconazole results in decreased expression of PALLD mRNA |
CTD |
PMID:31099283 |
|
NCBI chr16:33,238,943...33,632,236
|
|
G |
Papolg |
poly(A) polymerase gamma |
increases expression |
ISO |
Ketoconazole results in increased expression of PAPOLG mRNA |
CTD |
PMID:36621641 |
|
NCBI chr14:97,827,712...97,861,024
|
|
G |
Parg |
poly (ADP-ribose) glycohydrolase |
increases expression |
ISO |
Ketoconazole results in increased expression of PARG mRNA |
CTD |
PMID:36621641 |
|
NCBI chr16:7,436,429...7,544,276
|
|
G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of PARP1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr13:94,839,484...94,871,295
|
|
G |
Pc |
pyruvate carboxylase |
affects expression increases expression |
EXP |
Ketoconazole affects the expression of PC mRNA Ketoconazole results in increased expression of PC mRNA |
CTD |
PMID:18355885 PMID:37077353 |
|
NCBI chr 1:211,228,708...211,327,792
|
|
G |
Pcbd1 |
pterin-4 alpha-carbinolamine dehydratase 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of PCBD1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr20:29,573,362...29,587,181
|
|
G |
Pcdh9 |
protocadherin 9 |
increases expression |
ISO |
Ketoconazole results in increased expression of PCDH9 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr15:69,340,108...70,237,531
|
|
G |
Pcna |
proliferating cell nuclear antigen |
increases expression |
EXP |
Ketoconazole results in increased expression of PCNA mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 3:139,951,948...139,955,820
|
|
G |
Pcnp |
PEST proteolytic signal containing nuclear protein |
decreases expression |
ISO |
Ketoconazole results in decreased expression of PCNP mRNA |
CTD |
PMID:36621641 |
|
NCBI chr11:44,592,766...44,607,372
|
|
G |
Pcsk5 |
proprotein convertase subtilisin/kexin type 5 |
increases expression |
ISO |
Ketoconazole results in increased expression of PCSK5 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 1:214,837,847...215,267,626
|
|
G |
Pcsk9 |
proprotein convertase subtilisin/kexin type 9 |
increases expression |
EXP |
Ketoconazole results in increased expression of PCSK9 mRNA |
CTD |
PMID:28263823 |
|
NCBI chr 5:126,440,102...126,462,507
|
|
G |
Pctp |
phosphatidylcholine transfer protein |
increases expression |
EXP |
Ketoconazole results in increased expression of PCTP mRNA |
CTD |
PMID:37077353 |
|
NCBI chr10:74,808,887...74,856,260
|
|
G |
Pde3b |
phosphodiesterase 3B |
decreases expression |
EXP |
Ketoconazole results in decreased expression of PDE3B mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 1:168,606,762...168,770,078
|
|
G |
Pdhb |
pyruvate dehydrogenase E1 subunit beta |
increases expression |
EXP |
Ketoconazole results in increased expression of PDHB mRNA |
CTD |
PMID:37077353 |
|
NCBI chr15:19,182,789...19,188,731
|
|
G |
Pdlim5 |
PDZ and LIM domain 5 |
increases expression |
ISO |
Ketoconazole results in increased expression of PDLIM5 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 2:230,952,251...231,120,329
|
|
G |
Pdyn |
prodynorphin |
decreases expression |
EXP |
Ketoconazole results in decreased expression of PDYN mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 3:137,354,161...137,366,503
|
|
G |
Pea15 |
proliferation and apoptosis adaptor protein 15 |
increases expression |
EXP |
Ketoconazole results in increased expression of PEA15 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr13:87,190,189...87,199,811
|
|
G |
Pecr |
peroxisomal trans-2-enoyl-CoA reductase |
affects expression |
EXP |
Ketoconazole affects the expression of PECR mRNA |
CTD |
PMID:18355885 |
|
NCBI chr 9:73,897,877...73,926,511
|
|
G |
Pepd |
peptidase D |
increases expression |
EXP |
Ketoconazole results in increased expression of PEPD mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 1:87,536,650...87,681,233
|
|
G |
Per3 |
period circadian regulator 3 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of PER3 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 5:166,740,914...166,778,243
|
|
G |
Perp |
p53 apoptosis effector related to PMP22 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of PERP mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 1:15,361,784...15,374,230
|
|
G |
Pf4 |
platelet factor 4 |
increases expression |
EXP |
Ketoconazole results in increased expression of PF4 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr14:17,582,477...17,583,392
|
|
G |
Pgf |
placental growth factor |
increases expression |
EXP |
Ketoconazole results in increased expression of PGF mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 6:110,547,165...110,557,747
|
|
G |
Pgr |
progesterone receptor |
increases expression |
ISO |
Ketoconazole results in increased expression of PGR mRNA |
CTD |
PMID:35307500 |
|
NCBI chr 8:14,354,398...14,413,271
|
|
G |
Phf6 |
PHD finger protein 6 |
increases expression |
ISO |
Ketoconazole results in increased expression of PHF6 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr X:137,576,214...137,619,297
|
|
G |
Phf7 |
PHD finger protein 7 |
increases expression |
ISO |
Ketoconazole results in increased expression of PHF7 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr16:6,433,535...6,446,314
|
|
G |
Pim1 |
Pim-1 proto-oncogene, serine/threonine kinase |
decreases expression |
ISO |
Ketoconazole results in decreased expression of PIM1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr20:7,556,496...7,560,747
|
|
G |
Pip5k1a |
phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha |
increases expression |
ISO |
Ketoconazole results in increased expression of PIP5K1A mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 2:185,317,319...185,361,859
|
|
G |
Pkp2 |
plakophilin 2 |
increases expression |
ISO |
Ketoconazole results in increased expression of PKP2 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr11:98,165,974...98,231,916
|
|
G |
Pla2g3 |
phospholipase A2, group III |
increases expression |
EXP |
Ketoconazole results in increased expression of PLA2G3 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr14:82,589,908...82,597,542
|
|
G |
Pla2g7 |
phospholipase A2 group VII |
decreases expression |
EXP |
Ketoconazole results in decreased expression of PLA2G7 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr 9:17,362,214...17,404,476
|
|
G |
Plaat3 |
phospholipase A and acyltransferase 3 |
increases expression |
ISO |
Ketoconazole results in increased expression of PLAAT3 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 1:204,782,608...204,816,397
|
|
G |
Plag1 |
PLAG1 zinc finger |
decreases expression |
EXP |
Ketoconazole results in decreased expression of PLAG1 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr 5:16,902,057...16,956,727
|
|
G |
Plcxd2 |
phosphatidylinositol-specific phospholipase C, X domain containing 2 |
increases expression |
EXP |
Ketoconazole results in increased expression of PLCXD2 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr11:54,800,977...54,853,348
|
|
G |
Plekha4 |
pleckstrin homology domain containing A4 |
increases expression |
EXP |
Ketoconazole results in increased expression of PLEKHA4 mRNA |
CTD |
PMID:28263823 |
|
NCBI chr 1:96,005,824...96,028,826
|
|
G |
Plin4 |
perilipin 4 |
increases expression |
EXP |
Ketoconazole results in increased expression of PLIN4 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 9:929,168...938,062
|
|
G |
Plscr4 |
phospholipid scramblase 4 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of PLSCR4 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 8:92,987,290...93,026,056
|
|
G |
Pmm1 |
phosphomannomutase 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of PMM1 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 7:113,466,632...113,477,004
|
|
G |
Pmvk |
phosphomevalonate kinase |
increases expression |
EXP |
Ketoconazole results in increased expression of PMVK mRNA |
CTD |
PMID:28263823 PMID:37077353 |
|
NCBI chr 2:177,174,344...177,184,076
|
|
G |
Pnpla6 |
patatin-like phospholipase domain containing 6 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of PNPLA6 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr12:1,574,387...1,603,735
|
|
G |
Polr1d |
RNA polymerase I and III subunit D |
decreases expression |
ISO |
Ketoconazole results in decreased expression of POLR1D mRNA |
CTD |
PMID:36621641 |
|
NCBI chr12:7,970,592...8,004,157
|
|
G |
Pomc |
proopiomelanocortin |
decreases expression |
ISO |
Ketoconazole results in decreased expression of POMC protein modified form |
CTD |
PMID:25808816 |
|
NCBI chr 6:32,659,137...32,665,175
|
|
G |
Pon2 |
paraoxonase 2 |
increases expression |
ISO |
Ketoconazole results in increased expression of PON2 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 4:33,389,702...33,425,186
|
|
G |
Por |
cytochrome p450 oxidoreductase |
affects expression multiple interactions increases expression decreases expression |
EXP ISO |
Ketoconazole affects the expression of POR mRNA Ketoconazole affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] Ketoconazole results in increased expression of POR protein Ketoconazole results in decreased expression of POR mRNA |
CTD |
PMID:17966066 PMID:18355885 PMID:24120545 PMID:36653537 |
|
NCBI chr12:26,587,674...26,655,612
|
|
G |
Pou2f1 |
POU class 2 homeobox 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of POU2F1 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr13:80,653,602...80,796,279
|
|
G |
Pou5f1 |
POU class 5 homeobox 1 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of POU5F1 mRNA |
CTD |
PMID:16574651 |
|
NCBI chr20:3,227,836...3,232,598
|
|
G |
Ppara |
peroxisome proliferator activated receptor alpha |
multiple interactions |
EXP |
Ketoconazole inhibits the reaction [Clofibrate results in increased expression of PPARA mRNA] |
CTD |
PMID:14690017 |
|
NCBI chr 7:118,712,261...118,780,723
|
|
G |
Ppard |
peroxisome proliferator-activated receptor delta |
increases expression |
EXP |
Ketoconazole results in increased expression of PPARD mRNA |
CTD |
PMID:37077353 |
|
NCBI chr20:6,300,527...6,365,707
|
|
G |
Ppargc1a |
PPARG coactivator 1 alpha |
decreases expression |
EXP |
Ketoconazole results in decreased expression of PPARGC1A mRNA |
CTD |
PMID:37077353 |
|
NCBI chr14:63,073,505...63,729,215
|
|
G |
Ppargc1b |
PPARG coactivator 1 beta |
decreases expression |
EXP |
Ketoconazole results in decreased expression of PPARGC1B mRNA |
CTD |
PMID:37077353 |
|
NCBI chr18:54,758,891...54,861,103
|
|
G |
Ppp2cb |
protein phosphatase 2 catalytic subunit beta |
decreases expression |
EXP |
Ketoconazole results in decreased expression of PPP2CB mRNA |
CTD |
PMID:25787151 |
|
NCBI chr16:58,558,119...58,579,325
|
|
G |
Ppp2r2b |
protein phosphatase 2, regulatory subunit B, beta |
increases expression |
EXP |
Ketoconazole results in increased expression of PPP2R2B mRNA |
CTD |
PMID:37077353 |
|
NCBI chr18:34,653,716...35,080,889
|
|
G |
Ppp2r3a |
protein phosphatase 2, regulatory subunit B'', alpha |
decreases expression |
ISO |
Ketoconazole results in decreased expression of PPP2R3A mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 8:110,582,479...110,720,516
|
|
G |
Pqbp1 |
polyglutamine binding protein 1 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of PQBP1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr X:14,603,516...14,608,091
|
|
G |
Prc1 |
protein regulator of cytokinesis 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of PRC1 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 1:143,659,312...143,681,019
|
|
G |
Prcc |
proline rich mitotic checkpoint control factor |
increases expression |
ISO |
Ketoconazole results in increased expression of PRCC mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 2:173,326,261...173,351,799
|
|
G |
Prdm1 |
PR/SET domain 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of PRDM1 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr20:47,959,858...47,981,488
|
|
G |
Prdx3 |
peroxiredoxin 3 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of PRDX3 mRNA |
CTD |
PMID:25787151 |
|
NCBI chr 1:260,001,642...260,014,064
|
|
G |
Prkar1b |
protein kinase cAMP-dependent type I regulatory subunit beta |
decreases expression |
ISO |
Ketoconazole results in decreased expression of PRKAR1B mRNA |
CTD |
PMID:36621641 |
|
NCBI chr12:15,492,233...15,624,942
|
|
G |
Prkg2 |
protein kinase cGMP-dependent 2 |
increases expression |
EXP |
Ketoconazole results in increased expression of PRKG2 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr14:10,864,020...10,972,617
|
|
G |
Prkn |
parkin RBR E3 ubiquitin protein ligase |
multiple interactions increases expression increases response to substance |
EXP |
1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Ketoconazole results in increased expression of PRKN mRNA]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Ketoconazole results in increased expression of PRKN protein]; tempol inhibits the reaction [Ketoconazole results in increased expression of PRKN mRNA]; tempol inhibits the reaction [Ketoconazole results in increased expression of PRKN protein] Ketoconazole results in increased expression of PRKN mRNA; Ketoconazole results in increased expression of PRKN protein PRKN protein results in increased susceptibility to Ketoconazole |
CTD |
PMID:25787151 |
|
NCBI chr 1:51,236,410...52,430,242
|
|
G |
Prl |
prolactin |
decreases expression |
EXP |
Ketoconazole results in decreased expression of PRL mRNA |
CTD |
PMID:25808816 |
|
NCBI chr17:38,287,355...38,298,234
|
|
G |
Psmb8 |
proteasome 20S subunit beta 8 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of PSMB8 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr20:4,654,068...4,657,049
|
|
G |
Psmc2 |
proteasome 26S subunit, ATPase 2 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of PSMC2 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 4:14,148,080...14,162,390
|
|
G |
Psmd13 |
proteasome 26S subunit, non-ATPase 13 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of PSMD13 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 1:195,964,617...195,976,895
|
|
G |
Psmd5 |
proteasome 26S subunit, non-ATPase 5 |
increases expression |
ISO |
Ketoconazole results in increased expression of PSMD5 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 3:18,133,715...18,151,000
|
|
G |
Psmg3 |
proteasome assembly chaperone 3 |
increases expression |
ISO |
Ketoconazole results in increased expression of PSMG3 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr12:19,923,288...19,926,205
|
|
G |
Psmg4 |
proteasome assembly chaperone 4 |
increases expression |
ISO |
Ketoconazole results in increased expression of PSMG4 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr17:30,916,031...30,923,430
|
|
G |
Pten |
phosphatase and tensin homolog |
decreases expression |
EXP |
Ketoconazole results in decreased expression of PTEN mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 1:240,043,707...240,110,330
|
|
G |
Ptgds |
prostaglandin D2 synthase |
decreases expression increases expression |
ISO EXP |
Ketoconazole results in decreased expression of PTGDS mRNA Ketoconazole results in increased expression of PTGDS mRNA |
CTD |
PMID:31099283 PMID:36653537 |
|
NCBI chr 3:28,680,044...28,682,978
|
|
G |
Ptger2 |
prostaglandin E receptor 2 |
multiple interactions increases response to substance |
ISO |
PTGER2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; PTGER2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; PTGER2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]] PTGER2 protein results in increased susceptibility to Ketoconazole |
CTD |
PMID:16784723 |
|
NCBI chr15:18,215,013...18,228,714
|
|
G |
Ptger3 |
prostaglandin E receptor 3 |
multiple interactions increases response to substance increases expression |
ISO EXP |
PTGER3 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; PTGER3 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; PTGER3 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]] PTGER3 protein results in increased susceptibility to Ketoconazole Ketoconazole results in increased expression of PTGER3 mRNA |
CTD |
PMID:16784723 PMID:37077353 |
|
NCBI chr 2:246,606,131...246,750,970
|
|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions increases expression |
ISO |
Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [Dinoprostone results in increased expression of PTGS2 mRNA]]; Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [Dinoprostone results in increased expression of PTGS2 protein]]; Ketoconazole inhibits the reaction [Dinoprostone promotes the reaction [ATF1 protein modified form binds to PTGS2 promoter]]; Ketoconazole inhibits the reaction [Dinoprostone promotes the reaction [CREB1 protein modified form binds to PTGS2 promoter]]; Ketoconazole inhibits the reaction [Dinoprostone results in increased expression of PTGS2 mRNA]; Ketoconazole inhibits the reaction [Dinoprostone results in increased expression of PTGS2 protein] Ketoconazole results in increased expression of PTGS2 mRNA |
CTD |
PMID:12164941 PMID:32816093 |
|
NCBI chr13:64,714,063...64,722,320
|
|
G |
Pth |
parathyroid hormone |
multiple interactions |
EXP |
Ketoconazole inhibits the reaction [25-hydroxyvitamin D results in decreased expression of PTH mRNA] |
CTD |
PMID:18304585 |
|
NCBI chr 1:176,942,901...176,946,034
|
|
G |
Ptpn14 |
protein tyrosine phosphatase, non-receptor type 14 |
increases expression |
ISO |
Ketoconazole results in increased expression of PTPN14 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr13:103,799,473...103,951,708
|
|
G |
Ptprf |
protein tyrosine phosphatase, receptor type, F |
decreases expression |
EXP |
Ketoconazole results in decreased expression of PTPRF mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 5:131,741,959...131,824,000
|
|
G |
Ptx3 |
pentraxin 3 |
affects expression |
EXP |
Ketoconazole affects the expression of PTX3 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr 2:152,797,563...152,803,372
|
|
G |
Pygl |
glycogen phosphorylase L |
increases expression |
EXP |
Ketoconazole results in increased expression of PYGL mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 6:94,433,558...94,476,219
|
|
G |
Qsox1 |
quiescin sulfhydryl oxidase 1 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of QSOX1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr13:67,949,780...67,987,434
|
|
G |
Rab3b |
RAB3B, member RAS oncogene family |
increases expression |
ISO |
Ketoconazole results in increased expression of RAB3B mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 5:123,629,562...123,697,410
|
|
G |
Rab9a |
RAB9A, member RAS oncogene family |
increases expression |
ISO |
Ketoconazole results in increased expression of RAB9A mRNA |
CTD |
PMID:36621641 |
|
NCBI chr X:31,610,089...31,632,128
|
|
G |
Ralgdsl1 |
ral guanine nucleotide dissociation stimulator like 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of RGL1 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr13:67,184,402...67,454,019
|
|
G |
Rapgef1 |
Rap guanine nucleotide exchange factor 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of RAPGEF1 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 3:33,296,211...33,414,119
|
|
G |
Rapgef4 |
Rap guanine nucleotide exchange factor 4 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of RAPGEF4 mRNA |
CTD |
PMID:31099283 |
|
NCBI chr 3:56,809,388...57,101,332
|
|
G |
Rarb |
retinoic acid receptor, beta |
increases expression decreases expression |
EXP |
Ketoconazole results in increased expression of RARB mRNA Ketoconazole results in decreased expression of RARB mRNA |
CTD |
PMID:28263823 PMID:37077353 |
|
NCBI chr15:10,837,252...11,482,037
|
|
G |
Rarres2 |
retinoic acid receptor responder 2 |
increases expression |
EXP |
Ketoconazole results in increased expression of RARRES2 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 4:77,522,549...77,525,733
|
|
G |
Rbl2 |
RB transcriptional corepressor like 2 |
affects expression |
EXP |
Ketoconazole affects the expression of RBL2 mRNA |
CTD |
PMID:18355885 |
|
NCBI chr19:32,049,690...32,096,467
|
|
G |
Rbm26 |
RNA binding motif protein 26 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of RBM26 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr15:81,884,783...81,964,245
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
EXP |
Ketoconazole inhibits the reaction [Carbon Tetrachloride results in increased expression of RELA protein] |
CTD |
PMID:31168027 |
|
NCBI chr 1:212,354,336...212,364,815
|
|
G |
Ren |
renin |
decreases expression |
ISO |
Ketoconazole results in decreased expression of REN protein |
CTD |
PMID:2632720 |
|
NCBI chr13:47,348,312...47,359,539
|
|
G |
Rflna |
refilin A |
increases expression |
EXP |
Ketoconazole results in increased expression of RFLNA mRNA |
CTD |
PMID:28263823 |
|
NCBI chr12:31,633,360...31,642,313
|
|
G |
Rft1 |
RFT1 homolog |
decreases expression |
ISO |
Ketoconazole results in decreased expression of RFT1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr16:5,827,063...5,861,120
|
|
G |
Rgs16 |
regulator of G-protein signaling 16 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of RGS16 mRNA |
CTD |
PMID:31099283 |
|
NCBI chr13:68,421,480...68,443,312
|
|
G |
Rhno1 |
RAD9-HUS1-RAD1 interacting nuclear orphan 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of RHNO1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 4:161,634,047...161,639,437
|
|
G |
Rhob |
ras homolog family member B |
increases expression |
EXP |
Ketoconazole results in increased expression of RHOB mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 6:31,363,752...31,365,926
|
|
G |
Rilpl1 |
Rab interacting lysosomal protein-like 1 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of RILPL1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr12:32,071,870...32,109,687
|
|
G |
Rnase4 |
ribonuclease A family member 4 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of RNASE4 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr15:26,786,287...26,803,634
|
|
G |
Rnf115 |
ring finger protein 115 |
increases expression |
ISO |
Ketoconazole results in increased expression of RNF115 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 2:184,262,087...184,329,839
|
|
G |
Rnf41 |
ring finger protein 41 |
increases expression |
EXP |
Ketoconazole results in increased expression of RNF41 mRNA |
CTD |
PMID:25787151 |
|
NCBI chr 7:838,160...876,869
|
|
G |
Rnf8 |
ring finger protein 8 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of RNF8 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr20:7,682,258...7,710,448
|
|
G |
Rpp25 |
ribonuclease P and MRP subunit p25 |
increases expression |
ISO |
Ketoconazole results in increased expression of RPP25 mRNA |
CTD |
PMID:31099283 |
|
NCBI chr 8:57,907,352...57,908,732
|
|
G |
Rps25 |
ribosomal protein s25 |
increases expression |
ISO |
Ketoconazole results in increased expression of RPS25 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 8:53,630,333...53,632,810
|
|
G |
Rpsa |
ribosomal protein SA |
increases expression |
EXP |
Ketoconazole results in increased expression of RPSA mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 8:128,728,761...128,732,736
|
|
G |
Rrm2 |
ribonucleotide reductase regulatory subunit M2 |
increases expression |
ISO |
Ketoconazole results in increased expression of RRM2 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 6:47,044,755...47,075,370
|
|
G |
Rsf1 |
remodeling and spacing factor 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of RSF1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 1:151,892,055...152,015,089
|
|
G |
RT1-Bb |
RT1 class II, locus Bb |
decreases expression |
EXP |
Ketoconazole results in decreased expression of RT1-BB mRNA |
CTD |
PMID:36653537 |
|
NCBI chr20:4,598,475...4,604,118
|
|
G |
RT1-S3 |
RT1 class Ib, locus S3 |
affects expression |
EXP |
Ketoconazole affects the expression of RT1-S3 mRNA |
CTD |
PMID:18355885 |
|
NCBI chr20:2,670,654...2,675,411
|
|
G |
Runx2 |
RUNX family transcription factor 2 |
multiple interactions decreases expression |
ISO EXP |
Ketoconazole inhibits the reaction [Calcifediol results in increased expression of RUNX2 mRNA] Ketoconazole results in decreased expression of RUNX2 mRNA |
CTD |
PMID:21542014 PMID:37077353 |
|
NCBI chr 9:23,661,278...23,990,248
|
|
G |
Rxra |
retinoid X receptor alpha |
decreases expression |
EXP |
Ketoconazole results in decreased expression of RXRA mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 3:31,387,892...31,474,415
|
|
G |
Rxrg |
retinoid X receptor gamma |
decreases expression |
EXP |
Ketoconazole results in decreased expression of RXRG mRNA |
CTD |
PMID:37077353 |
|
NCBI chr13:82,276,330...82,318,097
|
|
G |
Samd8 |
sterile alpha motif domain containing 8 |
increases expression |
ISO |
Ketoconazole results in increased expression of SAMD8 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr15:2,512,104...2,562,368
|
|
G |
Sbno1 |
strawberry notch homolog 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of SBNO1 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr12:37,835,306...37,895,861
|
|
G |
Sc5d |
sterol-C5-desaturase |
increases expression |
EXP |
Ketoconazole results in increased expression of SC5D mRNA |
CTD |
PMID:28263823 |
|
NCBI chr 8:42,629,649...42,641,257
|
|
G |
Scarb1 |
scavenger receptor class B, member 1 |
decreases expression increases expression |
EXP ISO |
Ketoconazole results in decreased expression of SCARB1 mRNA Ketoconazole results in increased expression of SCARB1 mRNA |
CTD |
PMID:36621641 PMID:37077353 |
|
NCBI chr12:36,957,302...37,023,982
|
|
G |
Scarb2 |
scavenger receptor class B, member 2 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of SCARB2 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr14:15,558,271...15,609,813
|
|
G |
Scd |
stearoyl-CoA desaturase |
increases expression |
EXP ISO |
Ketoconazole results in increased expression of SCD mRNA; Ketoconazole results in increased expression of SCD1 mRNA Ketoconazole results in increased expression of SCD mRNA; Ketoconazole results in increased expression of SCD protein |
CTD |
PMID:28263823 PMID:36621641 PMID:37077353 |
|
NCBI chr 1:253,218,968...253,232,101
|
|
G |
Scgb1c1 |
secretoglobin, family 1C, member 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of SCGB1C1 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr 1:195,922,660...195,925,022
|
|
G |
Scp2 |
sterol carrier protein 2 |
increases expression |
EXP |
Ketoconazole results in increased expression of SCP2 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 5:128,035,714...128,110,015
|
|
G |
Sdc1 |
syndecan 1 |
increases expression |
EXP ISO |
Ketoconazole results in increased expression of SDC1 mRNA |
CTD |
PMID:36621641 PMID:37077353 |
|
NCBI chr 6:31,562,799...31,585,267
|
|
G |
Sdc4 |
syndecan 4 |
increases expression |
EXP |
Ketoconazole results in increased expression of SDC4 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr 3:153,154,888...153,173,576
|
|
G |
Secisbp2 |
SECIS binding protein 2 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of SECISBP2 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr17:13,538,513...13,569,573
|
|
G |
Sema3a |
semaphorin 3A |
decreases expression |
EXP |
Ketoconazole results in decreased expression of SEMA3A mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 4:21,282,398...21,754,834
|
|
G |
Sema3b |
semaphorin 3B |
multiple interactions |
ISO |
Ketoconazole promotes the reaction [Calcitriol results in increased expression of SEMA3B mRNA] |
CTD |
PMID:12040012 |
|
NCBI chr 8:108,271,663...108,280,326
|
|
G |
Sema3d |
semaphorin 3D |
affects expression |
ISO |
Ketoconazole affects the expression of SEMA3D mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 4:22,316,769...22,505,930
|
|
G |
Sema3e |
semaphorin 3E |
increases expression |
ISO |
Ketoconazole results in increased expression of SEMA3E mRNA |
CTD |
PMID:31099283 |
|
NCBI chr 4:20,297,534...20,555,287
|
|
G |
Sema7a |
semaphorin 7A (John Milton Hagen blood group) |
increases expression |
EXP |
Ketoconazole results in increased expression of SEMA7A mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 8:58,348,448...58,370,536
|
|
G |
Serpina1 |
serpin family A member 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of SERPINA1 mRNA |
CTD |
PMID:36653537 PMID:37077353 |
|
NCBI chr 6:128,631,101...128,653,125
|
|
G |
Serpina3n |
serpin family A member 3N |
increases expression |
ISO |
Ketoconazole results in increased expression of SERPINA3 mRNA |
CTD |
PMID:15342952 PMID:17175557 |
|
NCBI chr 6:123,323,623...123,331,181
|
|
G |
Serpinb1a |
serpin family B member 1A |
multiple interactions |
ISO |
Ketoconazole promotes the reaction [Calcitriol results in increased expression of SERPINB1 mRNA] |
CTD |
PMID:26485663 |
|
NCBI chr17:31,590,695...31,599,102
|
|
G |
Serpinb3 |
serpin family B member 3 |
multiple interactions |
ISO |
Ketoconazole promotes the reaction [Calcitriol results in decreased expression of SERPINB3 mRNA] |
CTD |
PMID:12040012 |
|
NCBI chr13:23,274,120...23,280,660
|
|
G |
Serpinh1 |
serpin family H member 1 |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [Tunicamycin results in decreased glycosylation of SERPINH1 protein] |
CTD |
PMID:16330322 |
|
NCBI chr 1:153,643,500...153,650,853
|
|
G |
Sestd1 |
SEC14 and spectrin domain containing 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of SESTD1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 3:62,123,590...62,220,759
|
|
G |
Sgk1 |
serum/glucocorticoid regulated kinase 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of SGK1 mRNA |
CTD |
PMID:36653537 PMID:37077353 |
|
NCBI chr 1:24,799,391...24,916,886
|
|
G |
Sh3d19 |
SH3 domain containing 19 |
increases expression |
ISO |
Ketoconazole results in increased expression of SH3D19 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 2:171,356,244...171,516,042
|
|
G |
Sh3gl3 |
SH3 domain containing GRB2 like 3, endophilin A3 |
affects expression |
EXP |
Ketoconazole affects the expression of SH3GL3 mRNA |
CTD |
PMID:18355885 |
|
NCBI chr 1:136,124,500...136,255,669
|
|
G |
Sh3rf1 |
SH3 domain containing ring finger 1 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of SH3RF1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr16:28,735,522...28,901,261
|
|
G |
Shq1 |
SHQ1, H/ACA ribonucleoprotein assembly factor |
increases expression |
EXP |
Ketoconazole results in increased expression of SHQ1 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr 4:133,213,357...133,305,586
|
|
G |
Shroom2 |
shroom family member 2 |
increases expression |
EXP |
Ketoconazole results in increased expression of SHROOM2 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr X:21,812,469...21,983,724
|
|
G |
Sirt1 |
sirtuin 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of SIRT1 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr20:25,305,953...25,328,000
|
|
G |
Sirt2 |
sirtuin 2 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of SIRT2 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 1:93,181,472...93,204,499
|
|
G |
Skap2 |
src kinase associated phosphoprotein 2 |
increases expression |
ISO |
Ketoconazole results in increased expression of SKAP2 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 4:80,948,832...81,100,900
|
|
G |
Slc10a1 |
solute carrier family 10 member 1 |
multiple interactions |
EXP |
[Chenodeoxycholic Acid co-treated with Ketoconazole] results in decreased expression of SLC10A1 mRNA |
CTD |
PMID:30985903 |
|
NCBI chr 6:100,613,045...100,626,670
|
|
G |
Slc17a7 |
solute carrier family 17 member 7 |
increases expression |
EXP |
Ketoconazole results in increased expression of SLC17A7 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 1:95,649,709...95,661,591
|
|
G |
Slc18a2 |
solute carrier family 18 member A2 |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [Maneb results in decreased expression of SLC18A2 protein]; Ketoconazole inhibits the reaction [Paraquat results in decreased expression of SLC18A2 protein] |
CTD |
PMID:22334051 |
|
NCBI chr 1:258,413,748...258,449,143
|
|
G |
Slc25a1 |
solute carrier family 25 member 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of SLC25A1 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr11:96,560,054...96,563,071
|
|
G |
Slc25a20 |
solute carrier family 25 member 20 |
increases expression |
EXP |
Ketoconazole results in increased expression of SLC25A20 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 8:109,365,056...109,386,512
|
|
G |
Slc25a36 |
solute carrier family 25 member 36 |
increases expression |
ISO |
Ketoconazole results in increased expression of SLC25A36 mRNA |
CTD |
PMID:31099283 |
|
NCBI chr 8:97,659,848...97,693,735
|
|
G |
Slc25a53 |
solute carrier family 25, member 53 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of SLC25A53 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr X:100,306,917...100,319,662
|
|
G |
Slc2a1 |
solute carrier family 2 member 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of SLC2A1 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 5:138,002,522...138,030,742
|
|
G |
Slc2a3 |
solute carrier family 2 member 3 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of SLC2A3 mRNA |
CTD |
PMID:15342952 PMID:17567588 |
|
NCBI chr 4:157,632,887...157,698,034
|
|
G |
Slc38a3 |
solute carrier family 38, member 3 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of SLC38A3 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 8:117,202,534...117,220,310
|
|
G |
Slc47a1 |
solute carrier family 47 member 1 |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] |
CTD |
PMID:22419765 |
|
NCBI chr10:46,533,580...46,590,128
|
|
G |
Slc47a2 |
solute carrier family 47 member 2 |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] |
CTD |
PMID:22419765 |
|
NCBI chr10:46,490,262...46,532,954
|
|
G |
Slc6a6 |
solute carrier family 6 member 6 |
affects expression |
EXP |
Ketoconazole affects the expression of SLC6A6 mRNA |
CTD |
PMID:18355885 |
|
NCBI chr 4:124,195,186...124,268,880
|
|
G |
Slc7a11 |
solute carrier family 7 member 11 |
increases expression |
ISO |
Ketoconazole results in increased expression of SLC7A11 mRNA |
CTD |
PMID:32816093 |
|
NCBI chr 2:136,532,912...136,668,560
|
|
G |
Slco1a4 |
solute carrier organic anion transporter family, member 1a4 |
affects expression |
EXP |
Ketoconazole affects the expression of SLCO1A4 mRNA |
CTD |
PMID:18355885 |
|
NCBI chr 4:174,710,004...174,764,810
|
|
G |
Slit2 |
slit guidance ligand 2 |
increases expression |
ISO |
Ketoconazole results in increased expression of SLIT2 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr14:66,829,661...67,168,517
|
|
G |
Slpi |
secretory leukocyte peptidase inhibitor |
decreases expression increases expression |
ISO EXP |
Ketoconazole results in decreased expression of SLPI mRNA Ketoconazole results in increased expression of SLPI mRNA |
CTD |
PMID:32816093 PMID:36653537 |
|
NCBI chr 3:173,501,573...173,503,822
|
|
G |
Smarcc1 |
SWI/SNF related BAF chromatin remodeling complex subunit C1 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of SMARCC1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 8:118,986,917...119,093,161
|
|
G |
Smim15 |
small integral membrane protein 15 |
increases expression |
ISO |
Ketoconazole results in increased expression of SMIM15 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 2:39,528,256...39,533,416
|
|
G |
Smim19 |
small integral membrane protein 19 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of SMIM19 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr16:69,551,507...69,564,323
|
|
G |
Smug1 |
single-strand-selective monofunctional uracil-DNA glycosylase 1 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of SMUG1 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 7:134,288,565...134,302,179
|
|
G |
Sncg |
synuclein, gamma |
increases expression |
EXP |
Ketoconazole results in increased expression of SNCG mRNA |
CTD |
PMID:37077353 |
|
NCBI chr16:9,700,513...9,705,751
|
|
G |
Snx1 |
sorting nexin 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of SNX1 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 8:66,630,086...66,670,418
|
|
G |
Snx18 |
sorting nexin 18 |
increases expression |
ISO |
Ketoconazole results in increased expression of SNX18 mRNA |
CTD |
PMID:36621641 |
|
NCBI chr 2:45,232,325...45,258,345
|
|
G |
Sod1 |
superoxide dismutase 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of SOD1 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr11:42,942,742...42,948,399
|
|
G |
Sox9 |
SRY-box transcription factor 9 |
increases expression |
EXP |
Ketoconazole results in increased expression of SOX9 mRNA |
CTD |
PMID:36653537 |
|
NCBI chr10:98,305,744...98,311,250
|
|
G |
Sp1 |
Sp1 transcription factor |
decreases expression |
EXP |
Ketoconazole results in decreased expression of SP1 mRNA |
CTD |
PMID:37077353 |
|
NCBI chr 7:135,419,864...135,450,513
|
|
G |
Sphk1 |
sphingosine kinase 1 |
increases expression |
EXP |
|