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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide
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Accession:CHEBI:47322 term browser browse the term
Definition:A member of the class of isoquinolines that is isoquinoline-8-sulfonamide which is substituted by chlorine at position 5 and in which the sulfonamide nitrogen is substituted by a 2-aminoethyl group. It is an inhibitor of casein kinase I.
Synonyms:related_synonym: CKI 7
 xref: CAS:120615-25-0;   DrugBank:DB03693
 xref_mesh: MESH:C058815
 xref: Patent:US4943581;   Reaxys:13642444;   pdb-ccd:CKI
 chemrof_formula: C11H12ClN3O2S
 chemrof_inchi: InChI=1S/C11H12ClN3O2S/c12-10-1-2-11(18(16,17)15-6-4-13)9-7-14-5-3-8(9)10/h1-3,5,7,15H,4,6,13H2
 chemrof_smiles: NCCNS(=O)(=O)c1ccc(Cl)c2ccncc12
 chemrof_inchikey: OGKYMFFYOWUTKV-UHFFFAOYSA-N


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N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Birc2 baculoviral IAP repeat-containing 2 multiple interactions ISO N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide promotes the reaction [TNFSF10 protein results in increased expression of BIRC2 protein] CTD PMID:15520213 NCBI chr 8:13,253,697...13,273,672
Ensembl chr 8:13,253,706...13,271,911 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide affects the localization of and results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:15520213 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699 		JBrowse link
G Csnk1a1 casein kinase 1, alpha 1 decreases activity ISO N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide results in decreased activity of CSNK1A1 protein CTD PMID:15520213 NCBI chr18:57,285,156...57,320,540
Ensembl chr18:57,287,412...57,320,538 		JBrowse link
G Tbx3 T-box transcription factor 3 decreases expression ISO N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide results in decreased expression of TBX3 mRNA CTD PMID:15255957 NCBI chr12:42,540,378...42,555,490
Ensembl chr12:42,540,378...42,554,171 		JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b increases expression ISO N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide results in increased expression of TNFRSF10A protein CTD PMID:15520213 NCBI chr15:51,249,883...51,278,091
Ensembl chr15:51,250,112...51,278,082 		JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide promotes the reaction [TNFSF10 protein results in increased expression of BIRC2 protein]; N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide promotes the reaction [TNFSF10 protein results in increased expression of XIAP protein] CTD PMID:15520213 NCBI chr 2:112,136,550...112,155,903 JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions ISO N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide promotes the reaction [TNFSF10 protein results in increased expression of XIAP protein] CTD PMID:15520213 NCBI chr  X:125,756,107...125,803,979
Ensembl chr  X:125,737,971...125,803,978 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    role 20844
      chemical role 20219
        acceptor 17380
          Bronsted base 17175
            organic amino compound 17164
              primary amino compound 7453
                N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      carbon group element atom 20712
                        carbon atom 20706
                          organic molecular entity 20706
                            organic molecule 20499
                              organic cyclic compound 20390
                                organic heterocyclic compound 19381
                                  organonitrogen heterocyclic compound 18491
                                    isoquinolines 494
                                      N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide 7
paths to the root