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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:1,4-dioxane
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Accession:CHEBI:47032 term browser browse the term
Definition:A dioxane with oxygen atoms at positions 1 and 4.
Synonyms:related_synonym: 1,4-DIETHYLENE DIOXIDE;   1,4-Dioxan;   1,4-dioxacyclohexane;   Formula=C4H8O2;   InChI=1S/C4H8O2/c1-2-6-4-3-5-1/h1-4H2;   InChIKey=RYHBNJHYFVUHQT-UHFFFAOYSA-N;   SMILES=C1COCCO1;   di(ethylene oxide);   glycol ethylene ether;   p-Dioxane;   tetrahydro-1,4-dioxin;   tetrahydro-p-dioxin;   tetrahydro-para-dioxin
 alt_id: CHEBI:34064;   CHEBI:41951;   CHEBI:46925
 xref: Beilstein:102551;   CAS:123-91-1;   DrugBank:DB03316;   KEGG:C14440;   LINCS:LSM-37087
 xref_mesh: MESH:C025223
 xref: PDBeChem:DIO;   PMID:14550759;   PMID:18044507;   PMID:20598439;   PPDB:1638;   Reaxys:102551;   Wikipedia:1\,4-Dioxane


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1,4-dioxane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aaas aladin WD repeat nucleoporin increases expression ISO 1,4-dioxane results in increased expression of AAAS mRNA CTD PMID:33693819 NCBI chr 7:133,464,315...133,483,961
Ensembl chr 7:133,464,315...133,483,961 		JBrowse link
G Aox1 aldehyde oxidase 1 increases expression ISO 1,4-dioxane results in increased expression of AOX1 mRNA CTD PMID:33693819 NCBI chr 9:59,579,621...59,658,772
Ensembl chr 9:59,579,649...59,658,770 		JBrowse link
G Atp6v0d2 ATPase H+ transporting V0 subunit D2 decreases expression ISO 1,4-dioxane results in decreased expression of ATP6V0D2 mRNA CTD PMID:33693819 NCBI chr 5:33,336,257...33,385,354
Ensembl chr 5:33,336,264...33,385,354 		JBrowse link
G Atp8b5 ATPase, class I, type 8B, member 5 increases expression ISO 1,4-dioxane results in increased expression of ATP8B5 mRNA CTD PMID:33693819 NCBI chr 5:57,505,897...57,620,065
Ensembl chr 5:57,506,466...57,620,056 		JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression ISO 1,4-dioxane results in increased expression of BTG2 mRNA CTD PMID:33693819 NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628 		JBrowse link
G Ccnb1 cyclin B1 increases expression ISO 1,4-dioxane results in increased expression of CCNB1 protein CTD PMID:20025956 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccng1 cyclin G1 increases expression ISO 1,4-dioxane results in increased expression of CCNG1 mRNA CTD PMID:33693819 NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641 		JBrowse link
G Cpq carboxypeptidase Q decreases expression ISO 1,4-dioxane results in decreased expression of CPQ mRNA CTD PMID:33693819 NCBI chr 7:64,264,025...64,830,867
Ensembl chr 7:64,264,081...64,724,546 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions EXP 1,4-dioxane results in increased expression of and results in increased activity of CYP2B1 protein CTD PMID:15490126 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 multiple interactions EXP 1,4-dioxane results in increased expression of and results in increased activity of CYP2B2 protein CTD PMID:15490126 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
increases activity
increases expression		 EXP 1,4-dioxane results in increased expression of and results in increased activity of CYP2E1 protein
1,4-dioxane results in increased activity of CYP2E1 protein
1,4-dioxane results in increased expression of CYP2E1 mRNA		 CTD PMID:15490126 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp2g1 cytochrome P450, family 2, subfamily g, polypeptide 1 decreases expression ISO 1,4-dioxane results in decreased expression of CYP2G1 mRNA CTD PMID:33693819 NCBI chr 1:82,145,635...82,156,862
Ensembl chr 1:82,145,073...82,156,828 		JBrowse link
G Ddias DNA damage-induced apoptosis suppressor increases expression ISO 1,4-dioxane results in increased expression of DDIAS mRNA CTD PMID:33693819 NCBI chr 1:146,906,150...146,930,462
Ensembl chr 1:146,906,154...146,930,462 		JBrowse link
G Dglucy D-glutamate cyclase increases expression ISO 1,4-dioxane results in increased expression of DGLUCY mRNA CTD PMID:33693819 NCBI chr 6:120,055,480...120,130,910
Ensembl chr 6:120,055,460...120,130,910 		JBrowse link
G Eda2r ectodysplasin A2 receptor increases expression ISO 1,4-dioxane results in increased expression of EDA2R mRNA CTD PMID:33693819 NCBI chr  X:62,224,763...62,269,333
Ensembl chr  X:62,228,229...62,269,268 		JBrowse link
G Egr1 early growth response 1 increases expression ISO 1,4-dioxane results in increased expression of EGR1 mRNA CTD PMID:33693819 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Ephx1 epoxide hydrolase 1 increases expression ISO 1,4-dioxane results in increased expression of EPHX1 mRNA CTD PMID:33693819 NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 decreases expression ISO 1,4-dioxane results in decreased expression of ERBB4 mRNA CTD PMID:33693819 NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595 		JBrowse link
G Fitm1 fat storage-inducing transmembrane protein 1 increases expression ISO 1,4-dioxane results in increased expression of FITM1 mRNA CTD PMID:33693819 NCBI chr15:29,064,746...29,066,015
Ensembl chr15:29,064,707...29,066,015 		JBrowse link
G Fras1 Fraser extracellular matrix complex subunit 1 decreases expression ISO 1,4-dioxane results in decreased expression of FRAS1 mRNA CTD PMID:33693819 NCBI chr14:12,791,407...13,200,862
Ensembl chr14:12,793,599...13,200,726 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases expression ISO 1,4-dioxane results in increased expression of GSTM1 mRNA CTD PMID:33693819 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Gstm2 glutathione S-transferase mu 2 increases expression ISO 1,4-dioxane results in increased expression of GSTM2 mRNA CTD PMID:33693819 NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961 		JBrowse link
G Gstm5 glutathione S-transferase, mu 5 increases expression ISO 1,4-dioxane results in increased expression of GSTM3 mRNA CTD PMID:33693819 NCBI chr 2:195,531,599...195,534,562
Ensembl chr 2:195,531,495...195,534,553 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression ISO 1,4-dioxane results in increased expression of GSTP1 mRNA CTD PMID:33693819 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G H2ax H2A.X variant histone increases expression ISO
EXP		 1,4-dioxane results in increased expression of H2AX protein CTD PMID:33693819 PMID:37258237 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Hells helicase, lymphoid specific increases expression ISO 1,4-dioxane results in increased expression of HELLS protein CTD PMID:20025956 NCBI chr 1:236,701,704...236,748,239
Ensembl chr 1:236,701,758...236,746,844 		JBrowse link
G Hes1 hes family bHLH transcription factor 1 increases expression ISO 1,4-dioxane results in increased expression of HES1 mRNA CTD PMID:33693819 NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192 		JBrowse link
G Hexb hexosaminidase subunit beta decreases expression ISO 1,4-dioxane results in decreased expression of HEXB mRNA CTD PMID:33693819 NCBI chr 2:28,483,997...28,504,165
Ensembl chr 2:28,484,012...28,504,223 		JBrowse link
G Id1 inhibitor of DNA binding 1 increases expression ISO 1,4-dioxane results in increased expression of ID1 mRNA CTD PMID:33693819 NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419 		JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 increases expression ISO 1,4-dioxane results in increased expression of IL1RL1 protein CTD PMID:20025956 NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256 		JBrowse link
G Mcm3 minichromosome maintenance complex component 3 increases expression ISO 1,4-dioxane results in increased expression of MCM3 protein CTD PMID:20025956 NCBI chr 9:23,219,169...23,237,314
Ensembl chr 9:23,219,169...23,237,314 		JBrowse link
G Meg3 maternally expressed 3 decreases expression ISO 1,4-dioxane results in decreased expression of MEG3 mRNA CTD PMID:33693819 NCBI chr 6:128,491,808...128,524,010 JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase increases expression EXP 1,4-dioxane results in increased expression of MGMT mRNA CTD PMID:22084566 PMID:30155721 NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756 		JBrowse link
G Naaladl2 N-acetylated alpha-linked acidic dipeptidase-like 2 decreases expression ISO 1,4-dioxane results in decreased expression of NAALADL2 mRNA CTD PMID:33693819 NCBI chr 2:106,639,146...107,992,218
Ensembl chr 2:106,645,608...107,991,689 		JBrowse link
G Ncmap noncompact myelin associated protein decreases expression ISO 1,4-dioxane results in decreased expression of NCMAP mRNA CTD PMID:33693819 NCBI chr 5:147,608,042...147,623,266
Ensembl chr 5:147,610,677...147,618,775 		JBrowse link
G Nherf1 NHERF family PDZ scaffold protein 1 increases expression ISO 1,4-dioxane results in increased expression of NHERF1 protein CTD PMID:22434383 NCBI chr10:100,403,189...100,420,290
Ensembl chr10:100,403,069...100,420,598 		JBrowse link
G Pcna proliferating cell nuclear antigen increases expression EXP 1,4-dioxane results in increased expression of PCNA mRNA CTD PMID:30155721 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Phex phosphate regulating endopeptidase X-linked increases expression ISO 1,4-dioxane results in increased expression of PHEX protein CTD PMID:20025956 NCBI chr  X:37,607,553...37,856,183
Ensembl chr  X:37,610,760...37,854,469 		JBrowse link
G Phlda3 pleckstrin homology-like domain, family A, member 3 increases expression ISO 1,4-dioxane results in increased expression of PHLDA3 mRNA CTD PMID:33693819 NCBI chr13:47,193,250...47,196,335
Ensembl chr13:47,193,086...47,196,335 		JBrowse link
G Pim1 Pim-1 proto-oncogene, serine/threonine kinase increases expression ISO 1,4-dioxane results in increased expression of PIM1 mRNA CTD PMID:33693819 NCBI chr20:7,554,921...7,559,174
Ensembl chr20:7,554,921...7,559,174 		JBrowse link
G Ppp1r10 protein phosphatase 1, regulatory subunit 10 decreases expression ISO 1,4-dioxane results in decreased expression of PPP1R10 mRNA CTD PMID:33693819 NCBI chr20:2,822,995...2,838,125
Ensembl chr20:2,822,995...2,837,611 		JBrowse link
G Pygo1 pygopus family PHD finger 1 decreases expression ISO 1,4-dioxane results in decreased expression of PYGO1 mRNA CTD PMID:33693819 NCBI chr 8:73,666,210...73,684,873
Ensembl chr 8:73,665,593...73,684,869 		JBrowse link
G Rad51 RAD51 recombinase increases expression EXP 1,4-dioxane results in increased expression of RAD51 mRNA CTD PMID:37258237 NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035 		JBrowse link
G Rad51ap1 RAD51 associated protein 1 increases expression ISO 1,4-dioxane results in increased expression of RAD51AP1 protein CTD PMID:20025956 NCBI chr 4:159,759,454...159,772,473
Ensembl chr 4:159,759,459...159,772,524 		JBrowse link
G Rcan2 regulator of calcineurin 2 decreases expression ISO 1,4-dioxane results in decreased expression of RCAN2 mRNA CTD PMID:33693819 NCBI chr 9:16,959,478...17,174,823
Ensembl chr 9:16,959,480...17,174,856 		JBrowse link
G Rgs1 regulator of G-protein signaling 1 decreases expression ISO 1,4-dioxane results in decreased expression of RGS1 mRNA CTD PMID:33693819 NCBI chr13:56,018,546...56,022,889
Ensembl chr13:56,018,554...56,022,984 		JBrowse link
G Rsrp1 arginine and serine rich protein 1 decreases expression ISO 1,4-dioxane results in decreased expression of RSRP1 mRNA CTD PMID:33693819 NCBI chr 5:147,147,774...147,151,523
Ensembl chr 5:147,147,784...147,151,523 		JBrowse link
G RT1-Bb RT1 class II, locus Bb decreases expression ISO 1,4-dioxane results in decreased expression of H2-AB1 mRNA CTD PMID:33693819 NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597 		JBrowse link
G Serpina7 serpin family A member 7 increases expression ISO 1,4-dioxane results in increased expression of SERPINA7 mRNA CTD PMID:33693819 NCBI chr  X:102,663,242...102,722,319
Ensembl chr  X:102,663,405...102,669,040 		JBrowse link
G Slc17a8 solute carrier family 17 member 8 increases expression ISO 1,4-dioxane results in increased expression of SLC17A8 mRNA CTD PMID:33693819 NCBI chr 7:23,994,212...24,049,498
Ensembl chr 7:23,994,217...24,048,079 		JBrowse link
G Sugct succinylCoA:glutarate-CoA transferase decreases expression ISO 1,4-dioxane results in decreased expression of SUGCT mRNA CTD PMID:33693819 NCBI chr17:47,376,392...48,234,362
Ensembl chr17:47,376,521...48,234,376 		JBrowse link
G Sult1c2a sulfotransferase family 1C member 2A decreases expression ISO 1,4-dioxane results in decreased expression of SULT1C2 mRNA CTD PMID:33693819 NCBI chr 9:6,873,697...6,904,736
Ensembl chr 9:6,874,249...6,904,734 		JBrowse link
G Tgif1 TGFB-induced factor homeobox 1 increases expression ISO 1,4-dioxane results in increased expression of TGIF1 mRNA CTD PMID:33693819 NCBI chr 9:110,748,094...110,757,714
Ensembl chr 9:110,720,921...110,757,802 		JBrowse link
G Tsc22d3 TSC22 domain family, member 3 decreases expression ISO 1,4-dioxane results in decreased expression of TSC22D3 mRNA CTD PMID:33693819 NCBI chr  X:104,217,898...104,277,886
Ensembl chr  X:104,217,925...104,276,861 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 decreases expression ISO 1,4-dioxane results in decreased expression of UGT1A1 mRNA CTD PMID:33693819 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19922
    role 19894
      application 19735
        NMR chemical shift reference compound 18101
          1,4-dioxane 55
Path 2
Term Annotations click to browse term
  CHEBI ontology 19922
    subatomic particle 19892
      composite particle 19892
        hadron 19920
          baryon 19892
            nucleon 19920
              atomic nucleus 19892
                atom 19892
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19805
                        carbon atom 19802
                          organic molecular entity 19775
                            organic molecule 19755
                              organic cyclic compound 19545
                                organic heterocyclic compound 18906
                                  organic heteromonocyclic compound 17828
                                    saturated organic heteromonocyclic parent 11294
                                      dioxane 55
                                        1,4-dioxane 55
paths to the root