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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:1,4-dioxane
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Accession:CHEBI:47032 term browser browse the term
Definition:A dioxane with oxygen atoms at positions 1 and 4.
Synonyms:related_synonym: 1,4-DIETHYLENE DIOXIDE;   1,4-Dioxan;   1,4-dioxacyclohexane;   Formula=C4H8O2;   InChI=1S/C4H8O2/c1-2-6-4-3-5-1/h1-4H2;   InChIKey=RYHBNJHYFVUHQT-UHFFFAOYSA-N;   SMILES=C1COCCO1;   di(ethylene oxide);   glycol ethylene ether;   p-Dioxane;   tetrahydro-1,4-dioxin;   tetrahydro-p-dioxin;   tetrahydro-para-dioxin
 alt_id: CHEBI:34064;   CHEBI:41951;   CHEBI:46925
 xref: CAS:123-91-1;   DrugBank:DB03316;   KEGG:C14440;   LINCS:LSM-37087
 xref_mesh: MESH:C025223
 xref: PDBeChem:DIO;   PMID:14550759;   PMID:18044507;   PMID:20598439;   PPDB:1638;   Reaxys:102551;   Wikipedia:1\,4-Dioxane


show annotations for term's descendants           Sort by:
1,4-dioxane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aaas aladin WD repeat nucleoporin increases expression ISO 1,4-dioxane results in increased expression of AAAS mRNA CTD PMID:33693819 NCBI chr 7:135,342,901...135,362,545
Ensembl chr 7:135,342,901...135,362,545 		JBrowse link
G Aox1 aldehyde oxidase 1 increases expression ISO 1,4-dioxane results in increased expression of AOX1 mRNA CTD PMID:33693819 NCBI chr 9:67,073,831...67,152,980
Ensembl chr 9:67,073,821...67,152,980 		JBrowse link
G Atp6v0d2 ATPase H+ transporting V0 subunit D2 decreases expression ISO 1,4-dioxane results in decreased expression of ATP6V0D2 mRNA CTD PMID:33693819 NCBI chr 5:38,133,151...38,182,245
Ensembl chr 5:38,133,158...38,182,245 		JBrowse link
G Atp8b5 ATPase, class I, type 8B, member 5 increases expression ISO 1,4-dioxane results in increased expression of ATP8B5 mRNA CTD PMID:33693819 NCBI chr 5:62,302,213...62,415,843
Ensembl chr 5:62,302,275...62,415,834 		JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression ISO 1,4-dioxane results in increased expression of BTG2 mRNA CTD PMID:33693819 NCBI chr13:48,083,931...48,087,690
Ensembl chr13:48,083,931...48,087,690 		JBrowse link
G Ccnb1 cyclin B1 increases expression ISO 1,4-dioxane results in increased expression of CCNB1 protein CTD PMID:20025956 NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225 		JBrowse link
G Ccng1 cyclin G1 increases expression ISO 1,4-dioxane results in increased expression of CCNG1 mRNA CTD PMID:33693819 NCBI chr10:25,678,503...25,684,876
Ensembl chr10:25,677,885...25,683,766 		JBrowse link
G Cpq carboxypeptidase Q decreases expression ISO 1,4-dioxane results in decreased expression of CPQ mRNA CTD PMID:33693819 NCBI chr 7:66,148,973...66,719,189
Ensembl chr 7:66,149,377...66,716,137 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions EXP 1,4-dioxane results in increased expression of and results in increased activity of CYP2B1 protein CTD PMID:15490126 NCBI chr 1:90,646,098...90,669,762 JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 multiple interactions EXP 1,4-dioxane results in increased expression of and results in increased activity of CYP2B2 protein CTD PMID:15490126 NCBI chr 1:90,722,243...90,736,272 JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
increases activity
increases expression
affects metabolic processing
affects response to substance 		EXP
ISO 		1,4-dioxane results in increased expression of and results in increased activity of CYP2E1 protein
1,4-dioxane results in increased activity of CYP2E1 protein
1,4-dioxane results in increased expression of CYP2E1 mRNA
[CYP2E1 protein affects the metabolism of 1,4-dioxane] which affects the abundance of beta-hydroxyethoxyacetic acid
CYP2E1 protein affects the susceptibility to 1,4-dioxane 		CTD PMID:15490126 PMID:39192018 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495 		JBrowse link
G Cyp2g1 cytochrome P450, family 2, subfamily g, polypeptide 1 decreases expression ISO 1,4-dioxane results in decreased expression of CYP2G1 mRNA CTD PMID:33693819 NCBI chr 1:91,273,309...91,284,499
Ensembl chr 1:91,272,680...91,284,498 		JBrowse link
G Ddias DNA damage-induced apoptosis suppressor increases expression ISO 1,4-dioxane results in increased expression of DDIAS mRNA CTD PMID:33693819 NCBI chr 1:156,318,559...156,342,869
Ensembl chr 1:156,318,563...156,342,869 		JBrowse link
G Dglucy D-glutamate cyclase increases expression ISO 1,4-dioxane results in increased expression of DGLUCY mRNA CTD PMID:33693819 NCBI chr 6:125,785,075...125,860,496
Ensembl chr 6:125,785,087...125,860,496 		JBrowse link
G Eda2r ectodysplasin A2 receptor increases expression ISO 1,4-dioxane results in increased expression of EDA2R mRNA CTD PMID:33693819 NCBI chr  X:66,225,557...66,280,674
Ensembl chr  X:66,236,111...66,280,663 		JBrowse link
G Egr1 early growth response 1 increases expression ISO 1,4-dioxane results in increased expression of EGR1 mRNA CTD PMID:33693819 NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843 		JBrowse link
G Ephx1 epoxide hydrolase 1 increases expression ISO 1,4-dioxane results in increased expression of EPHX1 mRNA CTD PMID:33693819 NCBI chr13:95,246,079...95,275,852
Ensembl chr13:95,246,080...95,321,981 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 decreases expression ISO 1,4-dioxane results in decreased expression of ERBB4 mRNA CTD PMID:33693819 NCBI chr 9:76,973,386...78,045,633
Ensembl chr 9:76,973,227...78,045,772 		JBrowse link
G Fitm1 fat storage-inducing transmembrane protein 1 increases expression ISO 1,4-dioxane results in increased expression of FITM1 mRNA CTD PMID:33693819 NCBI chr15:33,034,705...33,035,974
Ensembl chr15:33,034,688...33,035,974 		JBrowse link
G Fras1 Fraser extracellular matrix complex subunit 1 decreases expression ISO 1,4-dioxane results in decreased expression of FRAS1 mRNA CTD PMID:33693819 NCBI chr14:13,095,370...13,506,895
Ensembl chr14:13,095,370...13,504,664 		JBrowse link
G Gsta5 glutathione S-transferase alpha 5 increases expression ISO 1,4-dioxane results in increased expression of GSTA1 mRNA CTD PMID:33693819 NCBI chr 8:87,985,768...87,997,766
Ensembl chr 8:87,985,258...87,997,765 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases expression ISO 1,4-dioxane results in increased expression of GSTM1 mRNA CTD PMID:33693819 NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:198,338,008...198,343,569 		JBrowse link
G Gstm2 glutathione S-transferase mu 2 increases expression ISO 1,4-dioxane results in increased expression of GSTM2 mRNA CTD PMID:33693819 NCBI chr 2:198,312,179...198,316,962 JBrowse link
G Gstm5 glutathione S-transferase, mu 5 increases expression ISO 1,4-dioxane results in increased expression of GSTM3 mRNA CTD PMID:33693819 NCBI chr 2:198,219,769...198,222,732
Ensembl chr 2:198,219,647...198,222,731 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression ISO 1,4-dioxane results in increased expression of GSTP1 mRNA CTD PMID:33693819 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705 		JBrowse link
G H2ax H2A.X variant histone increases expression ISO
EXP 		1,4-dioxane results in increased expression of H2AX protein CTD PMID:33693819 PMID:37258237 NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:53,568,281...53,573,079 		JBrowse link
G Hells helicase, lymphoid specific increases expression ISO 1,4-dioxane results in increased expression of HELLS protein CTD PMID:20025956 NCBI chr 1:246,113,580...246,159,230
Ensembl chr 1:246,114,096...246,159,228 		JBrowse link
G Hes1 hes family bHLH transcription factor 1 increases expression ISO 1,4-dioxane results in increased expression of HES1 mRNA CTD PMID:33693819 NCBI chr11:84,210,632...84,213,045
Ensembl chr11:84,210,633...84,213,061 		JBrowse link
G Hexb hexosaminidase subunit beta decreases expression ISO 1,4-dioxane results in decreased expression of HEXB mRNA CTD PMID:33693819 NCBI chr 2:30,218,608...30,238,771
Ensembl chr 2:30,218,608...30,238,771 		JBrowse link
G Id1 inhibitor of DNA binding 1 increases expression ISO 1,4-dioxane results in increased expression of ID1 mRNA CTD PMID:33693819 NCBI chr 3:161,671,525...161,672,691
Ensembl chr 3:161,671,538...161,672,685 		JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 increases expression ISO 1,4-dioxane results in increased expression of IL1RL1 protein CTD PMID:20025956 NCBI chr 9:50,157,326...50,222,888
Ensembl chr 9:50,204,551...50,222,891 		JBrowse link
G Mcm3 minichromosome maintenance complex component 3 increases expression ISO 1,4-dioxane results in increased expression of MCM3 protein CTD PMID:20025956 NCBI chr 9:30,715,602...30,733,746
Ensembl chr 9:30,715,602...30,733,746 		JBrowse link
G Meg3 maternally expressed 3 decreases expression ISO 1,4-dioxane results in decreased expression of MEG3 mRNA CTD PMID:33693819 NCBI chr 6:134,274,056...134,306,249 JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase increases expression EXP 1,4-dioxane results in increased expression of MGMT mRNA CTD PMID:22084566 PMID:30155721 NCBI chr 1:201,140,832...201,367,481
Ensembl chr 1:201,140,661...201,367,482 		JBrowse link
G Naaladl2 N-acetylated alpha-linked acidic dipeptidase-like 2 decreases expression ISO 1,4-dioxane results in decreased expression of NAALADL2 mRNA CTD PMID:33693819 NCBI chr 2:108,568,000...109,920,650
Ensembl chr 2:108,573,985...109,920,756 		JBrowse link
G Ncmap noncompact myelin associated protein decreases expression ISO 1,4-dioxane results in decreased expression of NCMAP mRNA CTD PMID:33693819 NCBI chr 5:152,893,173...152,921,175
Ensembl chr 5:152,894,316...152,902,414 		JBrowse link
G Nherf1 NHERF family PDZ scaffold protein 1 increases expression ISO 1,4-dioxane results in increased expression of NHERF1 protein CTD PMID:22434383 NCBI chr10:100,902,165...100,919,265
Ensembl chr10:100,901,227...100,919,579 		JBrowse link
G Pcna proliferating cell nuclear antigen increases expression EXP 1,4-dioxane results in increased expression of PCNA mRNA CTD PMID:30155721 NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901 		JBrowse link
G Phex phosphate regulating endopeptidase X-linked increases expression ISO 1,4-dioxane results in increased expression of PHEX protein CTD PMID:20025956 NCBI chr  X:41,422,561...41,671,226
Ensembl chr  X:41,426,101...41,671,226 		JBrowse link
G Phlda3 pleckstrin homology-like domain, family A, member 3 increases expression ISO 1,4-dioxane results in increased expression of PHLDA3 mRNA CTD PMID:33693819 NCBI chr13:49,745,003...49,748,088
Ensembl chr13:49,742,591...49,749,621 		JBrowse link
G Pim1 Pim-1 proto-oncogene, serine/threonine kinase increases expression ISO 1,4-dioxane results in increased expression of PIM1 mRNA CTD PMID:33693819 NCBI chr20:7,556,496...7,560,747
Ensembl chr20:7,556,113...7,561,764 		JBrowse link
G Ppp1r10 protein phosphatase 1, regulatory subunit 10 decreases expression ISO 1,4-dioxane results in decreased expression of PPP1R10 mRNA CTD PMID:33693819 NCBI chr20:2,827,802...2,842,418
Ensembl chr20:2,827,802...2,842,418 		JBrowse link
G Pygo1 pygopus family PHD finger 1 decreases expression ISO 1,4-dioxane results in decreased expression of PYGO1 mRNA CTD PMID:33693819 NCBI chr 8:82,546,866...82,565,526
Ensembl chr 8:82,546,848...82,565,523 		JBrowse link
G Rad51 RAD51 recombinase increases expression EXP 1,4-dioxane results in increased expression of RAD51 mRNA CTD PMID:37258237 NCBI chr 3:126,554,210...126,578,888
Ensembl chr 3:126,554,190...126,579,469 		JBrowse link
G Rad51ap1 RAD51 associated protein 1 increases expression ISO 1,4-dioxane results in increased expression of RAD51AP1 protein CTD PMID:20025956 NCBI chr 4:161,445,610...161,458,661
Ensembl chr 4:161,445,512...161,458,680 		JBrowse link
G Rcan2 regulator of calcineurin 2 decreases expression ISO 1,4-dioxane results in decreased expression of RCAN2 mRNA CTD PMID:33693819 NCBI chr 9:24,456,861...24,674,234
Ensembl chr 9:24,456,861...24,672,189 		JBrowse link
G Rgs1 regulator of G-protein signaling 1 decreases expression ISO 1,4-dioxane results in decreased expression of RGS1 mRNA CTD PMID:33693819 NCBI chr13:58,568,844...58,573,187
Ensembl chr13:58,568,844...58,573,187 		JBrowse link
G Rsrp1 arginine and serine rich protein 1 decreases expression ISO 1,4-dioxane results in decreased expression of RSRP1 mRNA CTD PMID:33693819 NCBI chr 5:152,431,448...152,435,202
Ensembl chr 5:152,431,478...152,435,126 		JBrowse link
G RT1-Bb RT1 class II, locus Bb decreases expression ISO 1,4-dioxane results in decreased expression of H2-AB1 mRNA CTD PMID:33693819 NCBI chr20:4,598,475...4,604,118
Ensembl chr20:4,598,475...4,604,118 		JBrowse link
G Serpina7 serpin family A member 7 increases expression ISO 1,4-dioxane results in increased expression of SERPINA7 mRNA CTD PMID:33693819 NCBI chr  X:107,452,044...107,510,958
Ensembl chr  X:107,452,044...107,457,681 		JBrowse link
G Slc17a8 solute carrier family 17 member 8 increases expression ISO 1,4-dioxane results in increased expression of SLC17A8 mRNA CTD PMID:33693819 NCBI chr 7:25,881,557...25,936,837
Ensembl chr 7:25,881,557...25,935,410 		JBrowse link
G Sugct succinylCoA:glutarate-CoA transferase decreases expression ISO 1,4-dioxane results in decreased expression of SUGCT mRNA CTD PMID:33693819 NCBI chr17:52,072,012...52,929,852
Ensembl chr17:52,072,052...52,930,281 		JBrowse link
G Sult1c2a sulfotransferase family 1C member 2A decreases expression ISO 1,4-dioxane results in decreased expression of SULT1C2 mRNA CTD PMID:33693819 NCBI chr 9:7,075,873...7,103,316
Ensembl chr 9:7,066,905...7,244,132 		JBrowse link
G Tgif1 TGFB-induced factor homeobox 1 increases expression ISO 1,4-dioxane results in increased expression of TGIF1 mRNA CTD PMID:33693819 NCBI chr 9:118,194,735...118,204,354
Ensembl chr 9:118,194,444...118,204,442 		JBrowse link
G Tsc22d3 TSC22 domain family, member 3 decreases expression ISO 1,4-dioxane results in decreased expression of TSC22D3 mRNA CTD PMID:33693819 NCBI chr  X:109,006,410...109,066,389
Ensembl chr  X:109,006,420...109,015,519 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 decreases expression ISO 1,4-dioxane results in decreased expression of UGT1A1 mRNA CTD PMID:33693819 NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      biological role 20818
        biochemical role 20264
          metabolite 20245
            1,4-dioxane 56
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            organic molecule 20654
                              organic cyclic compound 20404
                                organic heterocyclic compound 19388
                                  organic heteromonocyclic compound 18212
                                    saturated organic heteromonocyclic parent 11505
                                      dioxane 56
                                        1,4-dioxane 56
paths to the root