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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:dorzolamide hydrochloride
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Accession:CHEBI:4703 term browser browse the term
Definition:The hydrochloride salt of dorzolamide. It is used in ophthalmic solutions to lower increased intraocular pressure in the treatment of open-angle glaucoma and ocular hypertension.
Synonyms:exact_synonym: (SS,6S)-N-ethyl-6-methyl-2-sulfamoyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-4-aminium 7,7-dioxide chloride
 related_synonym: (4S,6S)-4-(ethylamino)-5,6-dihydro-6-methyl-4HH-thieno(2,3-b)thiopyran-2-sulfonamide 7,7-dioxide monohydrochloride;   (4S,6S)-4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide hydrochloride;   (4S,trans)-4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide hydrochloride;   Formula=C10H17ClN2O4S3;   InChI=1S/C10H16N2O4S3.ClH/c1-3-12-8-4-6(2)18(13,14)10-7(8)5-9(17-10)19(11,15)16;/h5-6,8,12H,3-4H2,1-2H3,(H2,11,15,16);1H/t6-,8-;/m0./s1;   InChIKey=OSRUSFPMRGDLAG-QMGYSKNISA-N;   SMILES=[Cl-].CC[NH2+][C@H]1C[C@H](C)S(=O)(=O)c2sc(cc12)S(N)(=O)=O;   dorzolamide HCl
 xref: Beilstein:5896026;   CAS:130693-82-2;   DrugBank:DB00869;   KEGG:D00653
 xref_mesh: MESH:C062765


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dorzolamide hydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ca3 carbonic anhydrase 3 multiple interactions ISO dorzolamide binds to and results in decreased activity of CA3 protein CTD PMID:17826101 NCBI chr 2:88,491,666...88,501,299
Ensembl chr 2:88,491,670...88,500,524 		JBrowse link
G Car2 carbonic anhydrase 2 multiple interactions ISO dorzolamide binds to and results in decreased activity of CA2 protein CTD PMID:17826101 NCBI chr 2:88,462,883...88,478,012
Ensembl chr 2:88,462,872...88,478,064 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      application 20621
        pharmaceutical 20416
          drug 20416
            cardiovascular drug 8994
              antihypertensive agent 1960
                dorzolamide hydrochloride 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      chalcogen 20491
                        oxygen atom 20457
                          oxygen molecular entity 20457
                            hydroxides 20230
                              oxoacid 19289
                                chalcogen oxoacid 13891
                                  sulfur oxoacid 13683
                                    sulfonic acid 11712
                                      sulfonic acid derivative 11712
                                        sulfonamide 5379
                                          dorzolamide 2
                                            dorzolamide hydrochloride 2
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