CHEBI ONTOLOGY - ANNOTATIONS |
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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
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Term: | D-ribofuranose |
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Accession: | CHEBI:47013
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browse the term
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Definition: | A ribofuranose having D-configuration. |
Synonyms: | related_synonym: | (3R,4S,5R)-5-(hydroxymethyl)tetrahydrofuran-2,3,4-triol; D-Ribose; Formula=C5H10O5; InChI=1S/C5H10O5/c6-1-2-3(7)4(8)5(9)10-2/h2-9H,1H2/t2-,3-,4-,5?/m1/s1; InChIKey=HMFHBZSHGGEWLO-SOOFDHNKSA-N; SMILES=OC[C@H]1OC(O)[C@H](O)[C@@H]1O; WURCS=2.0/1,1,0/[a222h-1x_1-4]/1/; ribose |
| alt_id: | CHEBI:4233; CHEBI:46999 |
| xref: | Beilstein:1904878; CAS:50-69-1; CAS:613-83-2; GlyTouCan:G31080DL; Gmelin:364108; KEGG:C00121 |
| xref_mesh: | MESH:D012266 |
| xref: | PMID:9506998; Patent:US2152662; Reaxys:1904878 |
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Ager |
advanced glycosylation end product-specific receptor |
multiple interactions increases expression |
ISO |
[Ribose co-treated with Glucose] results in increased expression of AGER protein; AGER protein affects the reaction [Ribose promotes the reaction [Glucose results in increased phosphorylation of RELA protein]] Ribose results in increased expression of AGER protein |
CTD |
PMID:30101366 |
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NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
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B2m |
beta-2 microglobulin |
increases glycation |
ISO |
Ribose results in increased glycation of B2M protein |
CTD |
PMID:21864514 |
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NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766
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Casp3 |
caspase 3 |
multiple interactions |
EXP |
[Creatine co-treated with Ribose] results in decreased activity of CASP3 protein |
CTD |
PMID:21220914 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Chuk |
component of inhibitor of nuclear factor kappa B kinase complex |
increases phosphorylation |
ISO |
Ribose results in increased phosphorylation of CHUK protein |
CTD |
PMID:30101366 |
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NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
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Ikbkb |
inhibitor of nuclear factor kappa B kinase subunit beta |
increases phosphorylation |
ISO |
Ribose results in increased phosphorylation of IKBKB protein |
CTD |
PMID:30101366 |
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NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
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Ins1 |
insulin 1 |
increases secretion |
ISO |
Ribose results in increased secretion of INS1 protein |
CTD |
PMID:30101366 |
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NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
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Nfkbia |
NFKB inhibitor alpha |
increases phosphorylation multiple interactions |
ISO |
Ribose results in increased phosphorylation of NFKBIA protein [Ribose co-treated with Glucose] results in increased phosphorylation of NFKBIA protein |
CTD |
PMID:30101366 |
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NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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Oat |
ornithine aminotransferase |
multiple interactions |
EXP |
Ribose inhibits the reaction [Cyclic AMP results in increased activity of OAT protein] |
CTD |
PMID:2827574 |
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NCBI chr 1:187,347,862...187,367,644
Ensembl chr 1:187,347,865...187,367,682
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Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions increases phosphorylation |
ISO |
[Ribose co-treated with Glucose] affects the localization of RELA protein; AGER protein affects the reaction [Ribose promotes the reaction [Glucose results in increased phosphorylation of RELA protein]]; Ribose promotes the reaction [Glucose results in increased phosphorylation of RELA protein] Ribose results in increased phosphorylation of RELA protein |
CTD |
PMID:30101366 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Casp3 |
caspase 3 |
multiple interactions |
ISO |
[9-deaza-9-(3-thienylmethyl)guanine co-treated with Deoxyguanosine] results in increased activity of CASP3 protein; Deoxycytidine inhibits the reaction [[9-deaza-9-(3-thienylmethyl)guanine co-treated with Deoxyguanosine] results in increased activity of CASP3 protein] |
CTD |
PMID:9297556 PMID:9403342 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions |
ISO |
CYP1A1 protein promotes the reaction [Aflatoxin B1 binds to Deoxyguanosine] |
CTD |
PMID:21907773 |
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
multiple interactions |
ISO |
CYP1A2 protein promotes the reaction [Aflatoxin B1 binds to Deoxyguanosine]; CYP1A2 protein promotes the reaction [Estrone binds to Deoxyguanosine] |
CTD |
PMID:21907773 |
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NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
multiple interactions |
ISO |
CYP1B1 protein promotes the reaction [Aflatoxin B1 binds to Deoxyguanosine] |
CTD |
PMID:21907773 |
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NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
multiple interactions |
ISO |
CYP3A4 protein promotes the reaction [Aflatoxin B1 binds to Deoxyguanosine]; CYP3A4 protein promotes the reaction [Estrone binds to Deoxyguanosine] |
CTD |
PMID:21907773 |
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NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Mgmt |
O-6-methylguanine-DNA methyltransferase |
decreases activity |
ISO |
Deoxyguanosine analog results in decreased activity of MGMT protein |
CTD |
PMID:17880193 |
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NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756
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Tymp |
thymidine phosphorylase |
increases abundance |
ISO |
TYMP protein results in increased abundance of 2-deoxyribose 1-phosphate |
CTD |
PMID:11103787 |
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NCBI chr 7:120,438,768...120,444,088
Ensembl chr 7:120,438,770...120,443,874 Ensembl chr 7:120,438,770...120,443,874
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Tymp |
thymidine phosphorylase |
increases abundance |
ISO |
TYMP protein results in increased abundance of 2-deoxyribose 1-phosphate |
CTD |
PMID:11103787 |
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NCBI chr 7:120,438,768...120,444,088
Ensembl chr 7:120,438,770...120,443,874 Ensembl chr 7:120,438,770...120,443,874
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Abcb11 |
ATP binding cassette subfamily B member 11 |
multiple interactions |
ISO |
[NADP co-treated with Uridine Diphosphate Glucuronic Acid co-treated with Phosphoadenosine Phosphosulfate] promotes the reaction [[Enzymes and Coenzymes results in increased metabolism of diosbulbin B] inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]]; [NADP co-treated with Uridine Diphosphate Glucuronic Acid co-treated with Phosphoadenosine Phosphosulfate] promotes the reaction [[Enzymes and Coenzymes results in increased metabolism of saikogenin A analog] inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]]; [NADP co-treated with Uridine Diphosphate Glucuronic Acid co-treated with Phosphoadenosine Phosphosulfate] promotes the reaction [[Enzymes and Coenzymes results in increased metabolism of saikogenin A] inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]] |
CTD |
PMID:35101544 |
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NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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Nat2 |
N-acetyltransferase 2 |
multiple interactions |
ISO |
[NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[SULT1A2 protein co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone] |
CTD |
PMID:20545351 |
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NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520
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Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
multiple interactions |
ISO |
[NQO1 protein co-treated with NADP co-treated with Phosphoadenosine Phosphosulfate co-treated with SULT1A1 protein] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone |
CTD |
PMID:20545351 |
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NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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P2ry1 |
purinergic receptor P2Y1 |
decreases activity |
ISO |
Phosphoadenosine Phosphosulfate results in decreased activity of P2RY1 protein |
CTD |
PMID:22273509 |
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NCBI chr 2:145,241,975...145,248,186
Ensembl chr 2:145,241,849...145,248,457
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Sult1a1 |
sulfotransferase family 1A member 1 |
multiple interactions increases sulfation |
ISO |
2,2',3,4,4',5',6-heptabromodiphenyl ether inhibits the reaction [[Estradiol co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of SULT1A1 protein]; 2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [[Estradiol co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of SULT1A1 protein]; [NQO1 protein co-treated with NADP co-treated with Phosphoadenosine Phosphosulfate co-treated with SULT1A1 protein] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone; Halogenated Diphenyl Ethers analog inhibits the reaction [[Estradiol co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of SULT1A1 protein]; pentabrominated diphenyl ether 100 inhibits the reaction [[Estradiol co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of SULT1A1 protein]; Pentachlorophenol inhibits the reaction [[Estradiol co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of SULT1A1 protein]; tetrabromobisphenol A inhibits the reaction [[Estradiol co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of SULT1A1 protein]; tribromodiphenyl ether 28 inhibits the reaction [[Estradiol co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of SULT1A1 protein] SULT1A1 protein results in increased sulfation of Phosphoadenosine Phosphosulfate |
CTD |
PMID:11425650 PMID:16601080 PMID:20545351 |
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NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
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Sult2a1 |
sulfotransferase family 2A member 1 |
multiple interactions |
ISO |
[Phosphoadenosine Phosphosulfate co-treated with SULT2A1 protein] affects the sulfation of Ethinyl Estradiol; Celecoxib affects the reaction [[Phosphoadenosine Phosphosulfate co-treated with SULT2A1 protein] affects the sulfation of Ethinyl Estradiol]; SULT2A1 protein affects the metabolism of [Phosphoadenosine Phosphosulfate co-treated with Ethinyl Estradiol] |
CTD |
PMID:15483193 |
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NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134
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Adora3 |
adenosine A3 receptor |
multiple interactions |
EXP ISO |
2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 mRNA]]; 2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 protein]]; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine binds to and results in increased activity of ADORA3 protein; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 mRNA]; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 protein] [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine binds to and results in increased activity of ADORA3 protein] which results in decreased susceptibility to Dizocilpine Maleate; [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine binds to and results in increased activity of ADORA3 protein] which results in decreased susceptibility to Scopolamine; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine binds to and results in increased activity of ADORA3 protein |
CTD |
PMID:12672554 PMID:15452191 PMID:19966059 |
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NCBI chr 2:193,352,759...193,392,946
Ensembl chr 2:193,388,713...193,392,357
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Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
ISO |
Pertussis Toxin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in increased phosphorylation of AKT1 protein]; wortmannin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:16116186 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Birc3 |
baculoviral IAP repeat-containing 3 |
decreases expression decreases response to substance |
ISO |
N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of BIRC3 mRNA BIRC3 protein results in decreased susceptibility to N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine |
CTD |
PMID:16088125 |
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NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
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Birc5 |
baculoviral IAP repeat-containing 5 |
decreases response to substance |
ISO |
BIRC5 protein results in decreased susceptibility to N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine |
CTD |
PMID:16088125 |
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NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
EXP |
N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of FOS mRNA] |
CTD |
PMID:15452191 |
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NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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Il12a |
interleukin 12A |
multiple interactions |
ISO |
N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of [IL12A protein binds to IL12B protein]; Pertussis Toxin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of [IL12A protein binds to IL12B protein]]; wortmannin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of [IL12A protein binds to IL12B protein]] |
CTD |
PMID:16116186 |
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NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
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Il12b |
interleukin 12B |
multiple interactions |
ISO |
N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of [IL12A protein binds to IL12B protein]; Pertussis Toxin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of [IL12A protein binds to IL12B protein]]; Wortmannin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of [IL12A protein binds to IL12B protein]] |
CTD |
PMID:16116186 |
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NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
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Naip6 |
NLR family, apoptosis inhibitory protein 6 |
decreases response to substance decreases expression |
ISO |
NAIP protein results in decreased susceptibility to N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of NAIP mRNA |
CTD |
PMID:16088125 |
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NCBI chr 2:31,507,423...31,559,098
Ensembl chr 2:31,507,424...31,570,542
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Nppa |
natriuretic peptide A |
multiple interactions |
EXP |
2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] |
CTD |
PMID:15452191 PMID:19966059 |
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NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
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Rgs2 |
regulator of G-protein signaling 2 |
multiple interactions |
EXP |
N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of RGS2 mRNA] |
CTD |
PMID:15452191 |
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NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385
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Slc9a1 |
solute carrier family 9 member A1 |
multiple interactions |
EXP |
N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of SLC9A1 protein] |
CTD |
PMID:15452191 |
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NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624
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Acta2 |
actin alpha 2, smooth muscle |
decreases expression |
ISO |
5'-S-methyl-5'-thioadenosine decreases expression of Acta2 mRNA in Mdr2-/- mouse liver and liver myofibroblasts |
RGD |
PMID:21209952 |
RGD:153297773 |
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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Adora2b |
adenosine A2B receptor |
multiple interactions |
ISO |
5'-S-methyl-5'-thioadenosine enhances the reaction [lipopolysaccharide increases expression of Adora2b mRNA in mouse liver myofibroblasts] |
RGD |
PMID:21209952 |
RGD:153297773 |
NCBI chr10:46,940,394...46,956,772
Ensembl chr10:46,940,384...46,956,772
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Akt1 |
AKT serine/threonine kinase 1 |
decreases phosphorylation multiple interactions |
ISO |
5'-methylthioadenosine results in decreased phosphorylation of AKT1 protein IL7 protein inhibits the reaction [5'-methylthioadenosine results in decreased phosphorylation of AKT1 protein] |
CTD |
PMID:31712395 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Ccl2 |
C-C motif chemokine ligand 2 |
decreases expression |
ISO |
5'-S-methyl-5'-thioadenosine decreases expression of Ccl2 mRNA in Mdr2-/- mouse liver and myofibroblasts |
RGD |
PMID:21209952 |
RGD:153297773 |
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Ccnd1 |
cyclin D1 |
decreases expression |
ISO |
5'-S-methyl-5'-thioadenosine decreases expression of cyclin-D1 mRNA in Mdr2-/- mouse liver myofibroblasts |
RGD |
PMID:21209952 |
RGD:153297773 |
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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Col1a1 |
collagen type I alpha 1 chain |
decreases expression |
ISO |
5'-methylthioadenosine results in decreased expression of COL1A1 mRNA 5'-S-methyl-5'-thioadenosine decreases expression of Col1a1 mRNA in Mdr2-/- mouse liver and liver myofibroblasts |
CTD RGD |
PMID:15983038 PMID:21209952 |
RGD:153297773 |
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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Col1a2 |
collagen type I alpha 2 chain |
decreases expression |
ISO |
5'-methylthioadenosine results in decreased expression of COL1A2 mRNA |
CTD |
PMID:15983038 |
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NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867
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Idh2 |
isocitrate dehydrogenase (NADP(+)) 2 |
increases abundance multiple interactions |
ISO |
IDH2 protein mutant form results in increased abundance of 5'-methylthioadenosine Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of 5'-methylthioadenosine] |
CTD |
PMID:27469509 |
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NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025
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Ifng |
interferon gamma |
multiple interactions decreases secretion |
ISO |
5'-methylthioadenosine inhibits the reaction [fumonisin B1 results in increased expression of IFNG mRNA] 5'-methylthioadenosine results in decreased secretion of IFNG protein |
CTD |
PMID:17080400 PMID:31712395 |
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NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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Ifnl1 |
interferon, lambda 1 |
multiple interactions |
ISO |
5'-methylthioadenosine inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of IFNL1 mRNA] |
CTD |
PMID:37611859 |
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NCBI chr 1:83,798,651...83,800,297
Ensembl chr 1:83,798,703...83,800,235
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Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
5'-methylthioadenosine inhibits the reaction [fumonisin B1 results in increased expression of IL1B mRNA] |
CTD |
PMID:17080400 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il2 |
interleukin 2 |
multiple interactions decreases secretion |
ISO |
5'-methylthioadenosine inhibits the reaction [fumonisin B1 results in increased expression of IL2 mRNA] 5'-methylthioadenosine results in decreased secretion of IL2 protein |
CTD |
PMID:17080400 PMID:31712395 |
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NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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Il33 |
interleukin 33 |
multiple interactions |
ISO |
5'-methylthioadenosine inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of IL33 mRNA] |
CTD |
PMID:37545493 |
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NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373
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Il6 |
interleukin 6 |
multiple interactions decreases expression |
ISO |
5'-methylthioadenosine inhibits the reaction [fumonisin B1 results in increased expression of IL6 mRNA] 5'-S-methyl-5'-thioadenosine decreases expression of Il6 mRNA in Mdr2-/- mouse liver |
CTD RGD |
PMID:17080400 PMID:21209952 |
RGD:153297773 |
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Il7 |
interleukin 7 |
multiple interactions |
ISO |
IL7 protein inhibits the reaction [5'-methylthioadenosine results in decreased phosphorylation of AKT1 protein] |
CTD |
PMID:31712395 |
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NCBI chr 2:94,235,219...94,280,075
Ensembl chr 2:94,234,766...94,280,075
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G |
Jund |
JunD proto-oncogene, AP-1 transcription factor subunit |
decreases expression |
ISO |
5'-S-methyl-5'-thioadenosine decreases expression of JunD protein in Mdr2-/- mouse liver myofibroblasts |
RGD |
PMID:21209952 |
RGD:153297773 |
NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799
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G |
Ltb |
lymphotoxin beta |
multiple interactions |
ISO |
5'-methylthioadenosine inhibits the reaction [fumonisin B1 results in increased expression of LTB mRNA] |
CTD |
PMID:17080400 |
|
NCBI chr20:3,627,536...3,629,381
Ensembl chr20:3,627,537...3,629,381
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G |
Mdm4 |
MDM4 regulator of p53 |
multiple interactions |
ISO |
5'-methylthioadenosine affects the splicing of and affects the expression of MDM4 mRNA alternative form |
CTD |
PMID:31712395 |
|
NCBI chr13:44,432,596...44,516,165
Ensembl chr13:44,406,213...44,474,226
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G |
Mki67 |
marker of proliferation Ki-67 |
decreases expression |
ISO |
5'-S-methyl-5'-thioadenosine decreases expression of Ki-67 protein in Mdr2-/- mouse liver |
RGD |
PMID:21209952 |
RGD:153297773 |
NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
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G |
Mmp13 |
matrix metallopeptidase 13 |
decreases expression |
ISO |
5'-S-methyl-5'-thioadenosine decreases expression of MMP13 mRNA in Mdr2-/- mouse liver |
RGD |
PMID:21209952 |
RGD:153297773 |
NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
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G |
Mtor |
mechanistic target of rapamycin kinase |
decreases phosphorylation |
ISO |
5'-methylthioadenosine results in decreased phosphorylation of MTOR protein |
CTD |
PMID:31712395 |
|
NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
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G |
Nos2 |
nitric oxide synthase 2 |
decreases expression |
ISO |
5'-S-methyl-5'-thioadenosine decreases expression of iNOS mRNA in Mdr2-/- mouse liver |
RGD |
PMID:21209952 |
RGD:153297773 |
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Rps6 |
ribosomal protein S6 |
decreases phosphorylation |
ISO |
5'-methylthioadenosine results in decreased phosphorylation of RPS6 protein |
CTD |
PMID:31712395 |
|
NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602 Ensembl chr 5:101,371,136...101,374,602
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G |
Tgfb1 |
transforming growth factor, beta 1 |
decreases expression |
ISO |
5'-S-methyl-5'-thioadenosine decreases expression of Tgfb1 mRNA in Mdr2-/- mouse liver myofibroblasts |
RGD |
PMID:21209952 |
RGD:153297773 |
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Tgfb2 |
transforming growth factor, beta 2 |
decreases expression |
ISO |
5'-S-methyl-5'-thioadenosine decreases expression of Tgfb2 mRNA in Mdr2-/- mouse liver and myofibroblasts |
RGD |
PMID:21209952 |
RGD:153297773 |
NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
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G |
Tnc |
tenascin C |
decreases expression |
ISO |
5'-S-methyl-5'-thioadenosine decreases expression of tenascin-C mRNA in Mdr2-/- mouse liver |
RGD |
PMID:21209952 |
RGD:153297773 |
NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
5'-S-methyl-5'-thioadenosine inhibits the reaction [lipopolysaccharide increases expression of Tnf-alpha mRNA and protein in mouse liver myofibroblasts] |
RGD |
PMID:21209952 |
RGD:153297773 |
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tp53 |
tumor protein p53 |
increases expression |
ISO |
5'-methylthioadenosine results in increased expression of TP53 protein |
CTD |
PMID:31712395 |
|
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Acta2 |
actin alpha 2, smooth muscle |
multiple interactions |
ISO |
Azacitidine inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA] |
CTD |
PMID:22841775 |
|
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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G |
Adamts1 |
ADAM metallopeptidase with thrombospondin type 1 motif, 1 |
decreases expression |
ISO |
Azacitidine results in decreased expression of ADAMTS1 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr11:24,932,227...24,941,068
Ensembl chr11:24,931,761...24,941,103
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G |
Adrb1 |
adrenoceptor beta 1 |
affects expression |
ISO |
Azacitidine affects the expression of ADRB1 mRNA |
CTD |
PMID:19002953 |
|
NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259
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G |
Adrb2 |
adrenoceptor beta 2 |
affects expression multiple interactions |
ISO |
Azacitidine affects the expression of ADRB2 mRNA Azacitidine inhibits the reaction [Particulate Matter results in decreased expression of ADRB2 mRNA] |
CTD |
PMID:19002953 PMID:30986742 |
|
NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
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G |
Afp |
alpha-fetoprotein |
increases expression |
ISO |
Azacitidine results in increased expression of AFP mRNA |
CTD |
PMID:27590069 |
|
NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480
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G |
Aggf1 |
angiogenic factor with G patch and FHA domains 1 |
increases expression |
ISO |
Azacitidine results in increased expression of AGGF1 mRNA |
CTD |
PMID:19194470 |
|
NCBI chr 2:26,619,336...26,646,050
Ensembl chr 2:26,619,339...26,645,952
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G |
Ahr |
aryl hydrocarbon receptor |
increases expression multiple interactions |
ISO |
Azacitidine results in increased expression of AHR mRNA [Azacitidine co-treated with Butyrates] inhibits the reaction [Chromium inhibits the reaction [Benzo(a)pyrene promotes the reaction [AHR protein binds to CYP1A1 promoter]]]; Azacitidine inhibits the reaction [Chromium inhibits the reaction [Benzo(a)pyrene promotes the reaction [AHR protein binds to CYP1A1 promoter]]] |
CTD |
PMID:12927368 PMID:17682057 |
|
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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G |
Ak5 |
adenylate kinase 5 |
increases expression |
ISO |
Azacitidine results in increased expression of AK5 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 2:241,397,297...241,581,483
Ensembl chr 2:241,397,297...241,581,458
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
ISO |
Azacitidine inhibits the reaction [TGFB1 protein results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:22841775 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Alad |
aminolevulinate dehydratase |
decreases expression |
ISO |
Azacitidine results in decreased expression of ALAD mRNA |
CTD |
PMID:19194470 |
|
NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474
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G |
Alb |
albumin |
decreases expression increases expression |
ISO |
Azacitidine results in decreased expression of ALB protein Azacitidine results in increased expression of ALB mRNA |
CTD |
PMID:27590069 |
|
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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G |
Aldh3a1 |
aldehyde dehydrogenase 3 family, member A1 |
multiple interactions |
ISO |
[Azacitidine co-treated with Butyrates] inhibits the reaction [Chromium inhibits the reaction [Benzo(a)pyrene results in increased expression of ALDH3A1 mRNA]]; Azacitidine inhibits the reaction [Chromium inhibits the reaction [Benzo(a)pyrene results in increased expression of ALDH3A1 mRNA]] |
CTD |
PMID:17682057 |
|
NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681
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G |
Andpro |
androgen regulated protein |
increases expression |
ISO |
Azacitidine results in increased expression of CST4 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 3:136,718,601...136,725,131
Ensembl chr 3:136,718,602...136,724,966
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G |
Anxa1 |
annexin A1 |
decreases expression |
EXP |
Azacitidine results in decreased expression of ANXA1 protein |
CTD |
PMID:17105402 |
|
NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
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G |
App |
amyloid beta precursor protein |
decreases methylation multiple interactions |
ISO |
Azacitidine results in decreased methylation of APP promoter Azacitidine results in increased expression of and results in increased cleavage of APP protein; Betaine inhibits the reaction [Azacitidine results in decreased methylation of APP promoter]; Betaine inhibits the reaction [Azacitidine results in increased expression of and results in increased cleavage of APP protein] |
CTD |
PMID:19635394 |
|
NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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G |
Aqp5 |
aquaporin 5 |
decreases methylation increases expression multiple interactions |
ISO |
Azacitidine results in decreased methylation of AQP5 promoter Azacitidine results in increased expression of AQP5 protein [Azacitidine results in decreased methylation of AQP5 promoter] which results in increased expression of AQP5 mRNA; Azacitidine promotes the reaction [SP1 protein binds to AQP5 promoter] |
CTD |
PMID:17198683 |
|
NCBI chr 7:130,722,675...130,726,207
Ensembl chr 7:130,721,748...130,726,209
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G |
Aqp9 |
aquaporin 9 |
multiple interactions increases expression |
ISO |
[Azacitidine results in increased expression of AQP9 mRNA] which results in increased uptake of arsenic trioxide; HNF1A mutant form inhibits the reaction [Azacitidine results in increased expression of AQP9 mRNA] |
CTD |
PMID:25953102 |
|
NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395
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G |
Ar |
androgen receptor |
multiple interactions increases expression |
ISO |
[Azacitidine analog results in increased expression of AR protein] which results in increased susceptibility to bicalutamide; [Azacitidine analog results in increased expression of AR protein] which results in increased susceptibility to Dihydrotestosterone |
CTD |
PMID:18324645 |
|
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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G |
Arhgap35 |
Rho GTPase activating protein 35 |
increases expression |
ISO |
Azacitidine results in increased expression of ARHGAP35 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 1:77,202,436...77,319,298
Ensembl chr 1:77,202,436...77,319,298
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G |
Arhgef2 |
Rho/Rac guanine nucleotide exchange factor 2 |
decreases expression |
ISO |
Azacitidine results in decreased expression of ARHGEF2 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 2:174,061,126...174,118,355
Ensembl chr 2:174,062,976...174,118,355
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G |
Art1 |
ADP-ribosyltransferase 1 |
increases expression |
ISO |
Azacitidine results in increased expression of ART1 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 1:156,478,096...156,487,172
Ensembl chr 1:156,482,621...156,487,172
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G |
Asb2 |
ankyrin repeat and SOCS box-containing 2 |
increases expression |
ISO |
Azacitidine results in increased expression of ASB2 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 6:122,474,754...122,511,014
Ensembl chr 6:122,474,756...122,510,854
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G |
Atp2b1 |
ATPase plasma membrane Ca2+ transporting 1 |
decreases expression |
ISO |
Azacitidine results in decreased expression of ATP2B1 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 7:33,735,595...33,845,226
Ensembl chr 7:33,735,871...33,843,295
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G |
Atp6v0c |
ATPase H+ transporting V0 subunit C |
increases expression |
ISO |
Azacitidine results in increased expression of ATP6V0C mRNA |
CTD |
PMID:20823114 |
|
NCBI chr10:13,196,204...13,202,580
Ensembl chr10:13,196,204...13,201,500
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G |
Aurka |
aurora kinase A |
multiple interactions |
ISO |
[Azacitidine co-treated with Thalidomide] affects the expression of AURKA mRNA |
CTD |
PMID:18720364 |
|
NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390
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G |
Bad |
BCL2-associated agonist of cell death |
increases expression multiple interactions |
EXP |
Azacitidine results in increased expression of BAD mRNA [Azacitidine co-treated with entinostat] results in increased expression of BAD mRNA |
CTD |
PMID:21224363 |
|
NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
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G |
Bak1 |
BCL2-antagonist/killer 1 |
multiple interactions increases expression |
EXP |
[Azacitidine co-treated with entinostat] results in increased expression of BAK1 mRNA Azacitidine results in increased expression of BAK1 mRNA |
CTD |
PMID:21224363 |
|
NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions increases expression |
ISO |
Bleomycin inhibits the reaction [Azacitidine results in increased expression of BAX mRNA] |
CTD |
PMID:32278510 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcat1 |
branched chain amino acid transaminase 1 |
decreases expression |
ISO |
Azacitidine results in decreased expression of BCAT1 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 4:177,964,834...178,046,573
Ensembl chr 4:177,964,834...178,046,597
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions decreases expression |
ISO |
Bleomycin inhibits the reaction [Azacitidine results in decreased expression of BCL2 mRNA]; Bleomycin inhibits the reaction [Azacitidine results in decreased expression of BCL2 protein] Azacitidine results in decreased expression of BCL2 mRNA; Azacitidine results in decreased expression of BCL2 protein |
CTD |
PMID:32278510 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bcl2l1 |
Bcl2-like 1 |
multiple interactions affects expression |
ISO |
[metacept-1 co-treated with Azacitidine] results in decreased expression of BCL2L1 [Azacitidine affects the expression of IL6R protein] which affects the expression of BCL2L1 protein |
CTD |
PMID:18443271 PMID:19148494 |
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NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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G |
Bcl2l13 |
Bcl2-like 13 |
increases expression |
ISO |
Azacitidine results in increased expression of BCL2L13 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 4:154,056,116...154,112,890
Ensembl chr 4:154,056,127...154,108,985
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G |
Bdnf |
brain-derived neurotrophic factor |
increases expression decreases methylation multiple interactions |
ISO |
Azacitidine results in increased expression of BDNF mRNA Azacitidine results in decreased methylation of BDNF promoter Tetrodotoxin inhibits the reaction [Azacitidine results in decreased methylation of BDNF promoter]; Tetrodotoxin inhibits the reaction [Azacitidine results in increased expression of BDNF mRNA] |
CTD |
PMID:18184782 |
|
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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G |
Bglap |
bone gamma-carboxyglutamate protein |
decreases expression |
EXP |
Azacitidine results in decreased expression of BGLAP protein |
CTD |
PMID:18037191 |
|
NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495
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G |
Bicd1 |
BICD cargo adaptor 1 |
decreases expression |
ISO |
Azacitidine results in decreased expression of BICD1 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 4:182,479,071...182,631,504
Ensembl chr 4:182,479,071...182,627,434
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G |
Bik |
BCL2-interacting killer |
multiple interactions increases expression |
EXP |
[Azacitidine co-treated with entinostat] results in increased expression of BIK mRNA Azacitidine results in increased expression of BIK mRNA |
CTD |
PMID:21224363 |
|
NCBI chr 7:114,672,277...114,691,296
Ensembl chr 7:114,672,277...114,691,296
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G |
Bmp15 |
bone morphogenetic protein 15 |
increases expression |
ISO |
Azacitidine results in increased expression of BMP15 mRNA |
CTD |
PMID:23395740 |
|
NCBI chr X:16,169,123...16,174,187
Ensembl chr X:16,169,123...16,174,187
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G |
Bnip3 |
BCL2 interacting protein 3 |
increases expression |
ISO |
Azacitidine results in increased expression of BNIP3 mRNA |
CTD |
PMID:25446377 |
|
NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
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G |
Bok |
BCL2 family apoptosis regulator BOK |
multiple interactions increases expression |
EXP |
[Azacitidine co-treated with entinostat] results in increased expression of BOK mRNA Azacitidine results in increased expression of BOK mRNA |
CTD |
PMID:21224363 |
|
NCBI chr 9:94,223,493...94,234,476
Ensembl chr 9:94,223,389...94,234,476
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G |
Bub1b |
BUB1 mitotic checkpoint serine/threonine kinase B |
multiple interactions |
ISO |
[Azacitidine co-treated with Thalidomide] affects the expression of BUB1B mRNA |
CTD |
PMID:18720364 |
|
NCBI chr 3:105,563,089...105,615,547
Ensembl chr 3:105,563,138...105,615,547
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G |
C17h6orf62 |
similar to human chromosome 6 open reading frame 62 |
increases expression |
ISO |
Azacitidine results in increased expression of C6ORF62 mRNA |
CTD |
PMID:19194470 |
|
NCBI chr17:40,256,211...40,267,851
Ensembl chr17:40,256,211...40,276,020
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G |
C3ar1 |
complement C3a receptor 1 |
increases expression |
ISO |
Azacitidine results in increased expression of C3AR1 mRNA |
CTD |
PMID:19194470 |
|
NCBI chr 4:156,074,747...156,084,680
Ensembl chr 4:156,075,389...156,084,701
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G |
Calca |
calcitonin-related polypeptide alpha |
decreases methylation |
ISO |
Azacitidine results in decreased methylation of CALCA promoter |
CTD |
PMID:19299654 |
|
NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
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G |
Cald1 |
caldesmon 1 |
increases expression |
ISO |
Azacitidine results in increased expression of CALD1 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 4:63,265,781...63,446,938
Ensembl chr 4:63,265,942...63,446,932
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G |
Calhm2 |
calcium homeostasis modulator family member 2 |
increases expression multiple interactions |
ISO |
Azacitidine results in increased expression of CALHM2 mRNA Cisplatin affects the reaction [Azacitidine results in increased expression of CALHM2 mRNA] |
CTD |
PMID:36336710 |
|
NCBI chr 1:246,022,324...246,028,050
Ensembl chr 1:246,022,324...246,028,218
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G |
Casp3 |
caspase 3 |
affects expression increases activity increases expression multiple interactions |
ISO |
Azacitidine affects the expression of CASP3 protein 5-azacytidine co-treated with doxorubicin increases activity of CASP3 protein in lung cancer cells Azacitidine results in increased expression of CASP3 mRNA [metacept-1 co-treated with Azacitidine] results in increased expression of CASP3 |
CTD RGD |
PMID:18443271 PMID:19148494 PMID:23395740 PMID:24356455 |
RGD:153344603 |
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp8 |
caspase 8 |
increases expression |
ISO |
Azacitidine results in increased expression of CASP8 mRNA |
CTD |
PMID:18082045 PMID:23395740 |
|
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Casp9 |
caspase 9 |
increases expression |
ISO |
Azacitidine results in increased expression of CASP9 mRNA |
CTD |
PMID:23395740 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Ccna1 |
cyclin A1 |
multiple interactions decreases expression |
ISO |
Azacitidine inhibits the reaction [MECP2 protein binds to CCNA1 promoter]; Azacitidine promotes the reaction [H3-4 protein modified form binds to CCNA1 promoter]; Azacitidine promotes the reaction [H4C16 protein modified form binds to CCNA1 promoter] Azacitidine results in decreased expression of CCNA1 mRNA |
CTD |
PMID:17698632 |
|
NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157
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G |
Ccna2 |
cyclin A2 |
multiple interactions decreases expression |
ISO |
[Azacitidine co-treated with Thalidomide] affects the expression of CCNA2 mRNA Azacitidine results in decreased expression of CCNA2 mRNA |
CTD |
PMID:18720364 PMID:20823114 |
|
NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
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G |
Ccnb1 |
cyclin B1 |
multiple interactions increases expression |
ISO |
[Azacitidine co-treated with Thalidomide] affects the expression of CCNB1 mRNA Azacitidine results in increased expression of CCNB1 protein |
CTD |
PMID:18720364 PMID:20607034 |
|
NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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G |
Ccnd1 |
cyclin D1 |
increases expression |
ISO |
Azacitidine results in increased expression of CCND1 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Ccnd2 |
cyclin D2 |
affects methylation multiple interactions |
ISO |
Azacitidine affects the methylation of CCND2 promoter [Azacitidine affects the methylation of CCND2 promoter] which affects the expression of CCND2 mRNA |
CTD |
PMID:17016690 |
|
NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495
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G |
Ccng2 |
cyclin G2 |
decreases expression |
ISO |
Azacitidine results in decreased expression of CCNG2 mRNA |
CTD |
PMID:21245298 |
|
NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830
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G |
Cd274 |
CD274 molecule |
multiple interactions |
ISO |
Azacitidine inhibits the reaction [Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of CD274 mRNA]]; Azacitidine inhibits the reaction [Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of CD274 protein]] |
CTD |
PMID:32894642 |
|
NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:227,116,649...227,134,450
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G |
Cdc20 |
cell division cycle 20 |
multiple interactions |
ISO |
[Azacitidine co-treated with Thalidomide] affects the expression of CDC20 mRNA |
CTD |
PMID:18720364 |
|
NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512
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G |
Cdc42bpa |
CDC42 binding protein kinase alpha |
decreases expression |
ISO |
Azacitidine results in decreased expression of CDC42BPA mRNA |
CTD |
PMID:20823114 |
|
NCBI chr13:91,683,775...91,903,732
Ensembl chr13:91,684,007...91,903,732
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G |
Cdh1 |
cadherin 1 |
decreases methylation increases expression |
ISO |
Azacitidine results in decreased methylation of CDH1 promoter Azacitidine results in increased expression of CDH1 mRNA |
CTD |
PMID:17520682 |
|
NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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G |
Cdh2 |
cadherin 2 |
increases expression |
EXP |
Azacitidine results in increased expression of CDH2 mRNA |
CTD |
PMID:18037191 |
|
NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
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G |
Cdk1 |
cyclin-dependent kinase 1 |
multiple interactions increases expression |
ISO |
[Azacitidine co-treated with Thalidomide] affects the expression of CDK1 mRNA Azacitidine analog results in increased expression of CDK1 protein |
CTD |
PMID:18324645 PMID:18720364 |
|
NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
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G |
Cdk2 |
cyclin dependent kinase 2 |
decreases expression |
ISO |
Azacitidine analog results in decreased expression of CDK2 protein |
CTD |
PMID:18324645 |
|
NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
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G |
Cdk4 |
cyclin-dependent kinase 4 |
decreases expression |
ISO |
Azacitidine analog results in decreased expression of CDK4 protein |
CTD |
PMID:18324645 |
|
NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression multiple interactions |
ISO EXP |
Azacitidine analog results in increased expression of CDKN1A protein; Azacitidine results in increased expression of CDKN1A mRNA [Azacitidine co-treated with entinostat] results in increased expression of CDKN1A mRNA; Azacitidine inhibits the reaction [potassium bromate results in increased expression of CDKN1A protein] [metacept-1 co-treated with Azacitidine] results in increased expression of CDKN1A |
CTD |
PMID:18324645 PMID:19148494 PMID:20823114 PMID:21224363 PMID:25015661 |
|
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Cdkn1c |
cyclin-dependent kinase inhibitor 1C |
increases expression |
ISO |
Azacitidine results in increased expression of CDKN1C mRNA |
CTD |
PMID:19194470 |
|
NCBI chr 1:198,655,394...198,658,097
Ensembl chr 1:198,655,407...198,658,048
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G |
Cdkn2a |
cyclin-dependent kinase inhibitor 2A |
multiple interactions decreases methylation affects methylation increases expression |
EXP ISO |
[Azacitidine co-treated with entinostat] results in decreased methylation of CDKN2A gene; [Azacitidine co-treated with entinostat] results in increased expression of CDKN2A mRNA Azacitidine inhibits the reaction [Particulate Matter results in increased methylation of CDKN2A promoter] Hydroxyurea inhibits the reaction [Azacitidine results in decreased methylation of CDKN2A gene] Azacitidine affects the methylation of CDKN2A gene Azacitidine results in increased expression of CDKN2A mRNA |
CTD |
PMID:17686055 PMID:18443271 PMID:21224363 PMID:22355787 |
|
NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
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G |
Cdkn2b |
cyclin-dependent kinase inhibitor 2B |
decreases methylation multiple interactions affects response to substance |
ISO |
Azacitidine results in decreased methylation of CDKN2B promoter [metacept-1 co-treated with Azacitidine] results in increased expression of CDKN2B CDKN2B promoter modified form affects the susceptibility to Azacitidine |
CTD |
PMID:17611569 PMID:19148494 PMID:19194470 |
|
NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:104,010,680...104,019,050
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G |
Cebpa |
CCAAT/enhancer binding protein alpha |
decreases methylation increases expression |
ISO |
Azacitidine results in decreased methylation of CEBPA promoter Azacitidine results in increased expression of CEBPA mRNA |
CTD |
PMID:19194470 PMID:27590069 |
|
NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
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G |
Cenpa |
centromere protein A |
multiple interactions |
ISO |
[Azacitidine co-treated with Thalidomide] affects the expression of CENPA mRNA |
CTD |
PMID:18720364 |
|
NCBI chr 6:25,700,142...25,711,767
Ensembl chr 6:25,700,142...25,711,675
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G |
Cenpf |
centromere protein F |
multiple interactions |
ISO |
[Azacitidine co-treated with Thalidomide] affects the expression of CENPF mRNA |
CTD |
PMID:18720364 |
|
NCBI chr13:101,184,127...101,229,714
Ensembl chr13:101,184,127...101,229,669
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G |
Cenpo |
centromere protein O |
increases expression |
ISO |
Azacitidine results in increased expression of CENPO mRNA |
CTD |
PMID:19194470 |
|
NCBI chr 6:27,203,642...27,218,394
Ensembl chr 6:27,188,537...27,218,314
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G |
Chat |
choline O-acetyltransferase |
increases expression |
ISO |
Azacitidine results in increased expression of CHAT mRNA; Azacitidine results in increased expression of CHAT protein |
CTD |
PMID:19151599 |
|
NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093
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G |
Chga |
chromogranin A |
decreases expression |
ISO |
Azacitidine results in decreased expression of CHGA protein |
CTD |
PMID:20607034 |
|
NCBI chr 6:121,696,051...121,707,399
Ensembl chr 6:121,696,051...121,707,398
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G |
Chit1 |
chitinase 1 |
increases expression |
ISO |
Azacitidine results in increased expression of CHIT1 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr13:45,565,841...45,613,593
Ensembl chr13:45,593,845...45,613,592
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G |
Chrm1 |
cholinergic receptor, muscarinic 1 |
affects expression |
ISO |
Azacitidine affects the expression of CHRM1 mRNA |
CTD |
PMID:19002953 |
|
NCBI chr 1:205,567,226...205,583,001
Ensembl chr 1:205,567,220...205,582,356
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G |
Chrm2 |
cholinergic receptor, muscarinic 2 |
affects expression |
ISO |
Azacitidine affects the expression of CHRM2 mRNA |
CTD |
PMID:19002953 |
|
NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103
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G |
Chst14 |
carbohydrate sulfotransferase 14 |
increases expression |
EXP |
Azacitidine results in increased expression of CHST14 mRNA |
CTD |
PMID:27415467 |
|
NCBI chr 3:105,916,481...105,918,538
Ensembl chr 3:105,916,466...105,918,548
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G |
Ciita |
class II, major histocompatibility complex, transactivator |
multiple interactions increases expression |
ISO |
[Azacitidine promotes the reaction [IFNG protein results in increased expression of CIITA mRNA]] which results in increased expression of HLA-DRA protein; [Azacitidine results in decreased methylation of CIITA promoter] promotes the reaction [IFNG protein results in increased expression of CIITA mRNA] Azacitidine results in increased expression of CIITA mRNA |
CTD |
PMID:18829986 PMID:20823114 |
|
NCBI chr10:5,139,947...5,187,493
Ensembl chr10:5,140,178...5,187,440
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G |
Cldn10 |
claudin 10 |
decreases expression |
ISO |
Azacitidine results in decreased expression of CLDN10 mRNA |
CTD |
PMID:19194470 |
|
NCBI chr15:95,862,785...95,954,526
Ensembl chr15:95,862,760...95,954,526
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G |
Cldn6 |
claudin 6 |
increases expression decreases methylation multiple interactions |
ISO |
Azacitidine results in increased expression of CLDN6 mRNA Azacitidine results in decreased methylation of CLDN6 promoter [trichostatin A co-treated with Azacitidine] results in decreased methylation of CLDN6 promoter |
CTD |
PMID:18661270 |
|
NCBI chr10:12,710,302...12,713,987
Ensembl chr10:12,709,960...12,715,973
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G |
Cldn7 |
claudin 7 |
multiple interactions decreases expression |
ISO |
Cisplatin affects the reaction [Azacitidine results in decreased expression of CLDN7 mRNA] |
CTD |
PMID:36336710 |
|
NCBI chr10:54,689,684...54,692,177
Ensembl chr10:54,689,987...54,692,171
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G |
Cldn8 |
claudin 8 |
increases expression |
ISO |
Azacitidine results in increased expression of CLDN8 mRNA |
CTD |
PMID:18661270 |
|
NCBI chr11:27,875,857...27,878,106
Ensembl chr11:27,875,692...27,878,513
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G |
Cldn9 |
claudin 9 |
decreases methylation multiple interactions increases expression |
ISO |
Azacitidine results in decreased methylation of CLDN9 promoter [trichostatin A co-treated with Azacitidine] results in decreased methylation of CLDN9 promoter Azacitidine results in increased expression of CLDN9 mRNA |
CTD |
PMID:18661270 |
|
NCBI chr10:12,714,137...12,715,568
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G |
Cnnm2 |
cyclin and CBS domain divalent metal cation transport mediator 2 |
decreases expression |
ISO |
Azacitidine results in decreased expression of CNNM2 mRNA |
CTD |
PMID:19194470 |
|
NCBI chr 1:245,643,682...245,769,542
Ensembl chr 1:245,643,768...245,763,286
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G |
Col14a1 |
collagen type XIV alpha 1 chain |
increases expression |
ISO |
Azacitidine results in increased expression of COL14A1 mRNA |
CTD |
PMID:19194470 |
|
NCBI chr 7:86,722,093...86,937,215
Ensembl chr 7:86,722,094...86,937,214
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G |
Col1a1 |
collagen type I alpha 1 chain |
multiple interactions |
ISO |
Azacitidine inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; Azacitidine inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein] |
CTD |
PMID:22841775 |
|
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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G |
Col6a3 |
collagen type VI alpha 3 chain |
decreases expression |
ISO |
Azacitidine results in decreased expression of COL6A3 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 9:91,361,578...91,439,434
Ensembl chr 9:91,361,583...91,439,471
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G |
Col9a3 |
collagen type IX alpha 3 chain |
decreases expression |
ISO |
Azacitidine results in decreased expression of COL9A3 mRNA |
CTD |
PMID:18033690 |
|
NCBI chr 3:167,711,776...167,734,468
Ensembl chr 3:167,711,840...167,734,465
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G |
Cox6a2 |
cytochrome c oxidase subunit 6A2 |
increases expression |
ISO |
Azacitidine results in increased expression of COX6A2 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 1:182,788,528...182,790,746
Ensembl chr 1:182,788,528...182,789,274
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G |
Cpe |
carboxypeptidase E |
increases expression |
ISO |
Azacitidine results in increased expression of CPE mRNA |
CTD |
PMID:20823114 |
|
NCBI chr16:25,030,276...25,142,231
Ensembl chr16:25,030,276...25,142,233
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G |
Cplx1 |
complexin 1 |
increases expression |
ISO |
Azacitidine results in increased expression of CPLX1 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr14:1,184,677...1,216,392
|
|
G |
Creb1 |
cAMP responsive element binding protein 1 |
multiple interactions |
ISO |
Azacitidine promotes the reaction [CREB1 protein modified form binds to PPP2CA promoter] |
CTD |
PMID:19155497 |
|
NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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G |
Creb3l4 |
cAMP responsive element binding protein 3-like 4 |
increases expression |
EXP |
Azacitidine results in increased expression of CREB3L4 mRNA |
CTD |
PMID:27415467 |
|
NCBI chr 2:175,690,340...175,695,846
Ensembl chr 2:175,690,335...175,695,932
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G |
Crem |
cAMP responsive element modulator |
decreases expression |
ISO |
Azacitidine results in decreased expression of CREM mRNA |
CTD |
PMID:20823114 |
|
NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989
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G |
Cryaa |
crystallin, alpha A |
increases expression |
EXP |
Azacitidine results in increased expression of CRYAA protein |
CTD |
PMID:17105402 |
|
NCBI chr20:9,783,605...9,787,351
Ensembl chr20:9,783,605...9,787,349
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G |
Cryab |
crystallin, alpha B |
increases expression |
EXP |
Azacitidine results in increased expression of CRYAB protein |
CTD |
PMID:17105402 |
|
NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157
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G |
Csf1 |
colony stimulating factor 1 |
increases expression |
EXP |
Azacitidine results in increased expression of CSF1 mRNA |
CTD |
PMID:17156202 |
|
NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704
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G |
Csn1s1 |
casein alpha s1 |
increases expression |
ISO |
Azacitidine results in increased expression of CSN1S1 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr14:20,343,620...20,359,614
Ensembl chr14:20,343,619...20,359,614
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G |
Cst3 |
cystatin C |
increases expression |
ISO |
Azacitidine results in increased expression of CST3 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 3:136,336,923...136,340,796
Ensembl chr 3:136,336,920...136,340,822
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G |
Cxcl12 |
C-X-C motif chemokine ligand 12 |
decreases methylation increases expression |
ISO |
Azacitidine results in decreased methylation of CXCL12 promoter Azacitidine results in increased expression of CXCL12 mRNA; Azacitidine results in increased expression of CXCL12 protein |
CTD |
PMID:19748759 |
|
NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions increases expression |
ISO |
Azacitidine promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; Azacitidine promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] [Azacitidine co-treated with Butyrates] inhibits the reaction [Chromium inhibits the reaction [Benzo(a)pyrene promotes the reaction [AHR protein binds to CYP1A1 promoter]]]; [Azacitidine co-treated with Butyrates] inhibits the reaction [Chromium inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]]; Azacitidine inhibits the reaction [Chromium inhibits the reaction [Benzo(a)pyrene promotes the reaction [AHR protein binds to CYP1A1 promoter]]]; Azacitidine inhibits the reaction [Chromium inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]] Azacitidine results in increased expression of CYP1A1 mRNA |
CTD |
PMID:11281733 PMID:12927368 PMID:17682057 PMID:27590069 |
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
multiple interactions increases expression |
ISO |
Azacitidine promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A2 mRNA] Azacitidine results in increased expression of CYP1A2 mRNA |
CTD |
PMID:12927368 |
|
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
multiple interactions increases expression |
ISO |
Azacitidine promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA] Azacitidine results in increased expression of CYP1B1 mRNA |
CTD |
PMID:12927368 PMID:27590069 |
|
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
increases expression |
ISO |
Azacitidine results in increased expression of CYP3A4 mRNA |
CTD |
PMID:27590069 |
|
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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G |
Cyth1 |
cytohesin 1 |
increases expression |
ISO |
Azacitidine results in increased expression of CYTH1 mRNA |
CTD |
PMID:19194470 |
|
NCBI chr10:103,402,727...103,485,826
Ensembl chr10:103,366,145...103,485,760
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G |
Dapk1 |
death associated protein kinase 1 |
affects methylation |
ISO |
Azacitidine affects the methylation of DAPK1 promoter |
CTD |
PMID:17557868 |
|
NCBI chr17:3,930,223...4,090,991
Ensembl chr17:3,930,213...4,090,991
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G |
Dcn |
decorin |
multiple interactions decreases expression |
ISO |
Azacitidine promotes the reaction [[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of DCN protein] Azacitidine results in decreased expression of DCN mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 7:32,281,252...32,321,291
Ensembl chr 7:32,281,252...32,321,270
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G |
Des |
desmin |
increases expression multiple interactions |
EXP ISO |
Azacitidine results in increased expression of DES mRNA; Azacitidine results in increased expression of DES protein [Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate co-treated with Azacitidine] results in increased expression of DES mRNA |
CTD |
PMID:18037191 PMID:20823114 |
|
NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699
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G |
Dhx9 |
DExH-box helicase 9 |
decreases expression |
ISO |
Azacitidine results in decreased expression of DHX9 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr13:65,602,322...65,639,098
Ensembl chr13:65,602,323...65,639,069
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G |
Dio2 |
iodothyronine deiodinase 2 |
decreases expression |
ISO |
Azacitidine results in decreased expression of DIO2 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809
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G |
Dlk1 |
delta like non-canonical Notch ligand 1 |
decreases methylation |
ISO |
Azacitidine results in decreased methylation of DLK1 promoter |
CTD |
PMID:19194470 |
|
NCBI chr 6:128,410,216...128,417,518
Ensembl chr 6:128,410,316...128,417,522
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|
G |
Dlx5 |
distal-less homeobox 5 |
increases expression |
ISO |
Azacitidine results in increased expression of DLX5 mRNA |
CTD |
PMID:17085970 |
|
NCBI chr 4:34,999,139...35,003,504
Ensembl chr 4:34,999,139...35,003,407
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G |
Dlx6 |
distal-less homeobox 6 |
increases expression |
ISO |
Azacitidine results in increased expression of DLX6 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 4:34,984,264...34,989,926
Ensembl chr 4:34,984,232...34,991,343
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G |
Dnmt1 |
DNA methyltransferase 1 |
multiple interactions decreases expression |
ISO EXP |
[SLC28A1 protein results in increased uptake of Azacitidine] which results in decreased expression of DNMT1 protein; Arsenic Trioxide promotes the reaction [Azacitidine results in decreased expression of DNMT1 protein]; Azacitidine inhibits the reaction [DNMT1 protein binds to MIR497 promoter] [Azacitidine co-treated with entinostat] results in decreased expression of DNMT1 protein; [Cisplatin co-treated with Azacitidine] results in decreased expression of DNMT1 protein |
CTD |
PMID:19139132 PMID:19723570 PMID:21224363 PMID:28901456 PMID:35066776 |
|
NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659
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|
G |
Dnmt3a |
DNA methyltransferase 3 alpha |
multiple interactions |
ISO |
Azacitidine inhibits the reaction [DNMT3A protein binds to MIR497 promoter] |
CTD |
PMID:35066776 |
|
NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687
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G |
Dnmt3b |
DNA methyltransferase 3 beta |
multiple interactions |
ISO |
Azacitidine inhibits the reaction [DNMT3B protein binds to MIR497 promoter] |
CTD |
PMID:35066776 |
|
NCBI chr 3:142,130,588...142,169,128
Ensembl chr 3:142,130,592...142,169,124
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|
G |
Dpyd |
dihydropyrimidine dehydrogenase |
decreases methylation multiple interactions decreases response to substance |
ISO |
Azacitidine results in decreased methylation of DPYD promoter [Azacitidine results in decreased methylation of DPYD promoter] which results in increased expression of DPYD mRNA DPYD protein results in decreased susceptibility to Azacitidine |
CTD |
PMID:15501990 |
|
NCBI chr 2:206,609,043...207,474,982
Ensembl chr 2:206,609,122...207,474,982
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G |
Dusp1 |
dual specificity phosphatase 1 |
increases expression |
ISO |
Azacitidine results in increased expression of DUSP1 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr10:16,680,478...16,683,275
|
|
G |
Dusp6 |
dual specificity phosphatase 6 |
increases expression |
ISO |
Azacitidine results in increased expression of DUSP6 mRNA |
CTD |
PMID:21245298 |
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NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185
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G |
E2f1 |
E2F transcription factor 1 |
multiple interactions |
ISO |
E2F1 protein affects the reaction [Azacitidine results in decreased activity of TERT protein]; E2F1 protein affects the reaction [Azacitidine results in decreased expression of TERT mRNA] |
CTD |
PMID:19451745 |
|
NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361
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G |
Eef1a1 |
eukaryotic translation elongation factor 1 alpha 1 |
decreases expression |
ISO |
Azacitidine results in decreased expression of EEF1A1 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 8:79,341,554...79,344,784
Ensembl chr 8:79,341,557...79,344,839
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G |
Efna3 |
ephrin A3 |
increases expression |
ISO |
Azacitidine results in increased expression of EFNA3 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 2:174,729,192...174,738,111
Ensembl chr 2:174,729,764...174,738,736
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G |
Egr2 |
early growth response 2 |
increases expression |
ISO |
Azacitidine results in increased expression of EGR2 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562
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G |
Eno2 |
enolase 2 |
decreases expression |
ISO |
Azacitidine results in decreased expression of ENO2 protein |
CTD |
PMID:20607034 |
|
NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980
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G |
Entpd1 |
ectonucleoside triphosphate diphosphohydrolase 1 |
increases expression |
ISO |
Azacitidine results in increased expression of ENTPD1 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 1:239,425,515...239,552,323
Ensembl chr 1:239,425,430...239,552,317
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G |
Esr1 |
estrogen receptor 1 |
increases expression |
ISO |
Azacitidine results in increased expression of ESR1 protein |
CTD |
PMID:22558281 |
|
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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G |
Ets1 |
ETS proto-oncogene 1, transcription factor |
multiple interactions |
ISO |
Azacitidine promotes the reaction [ETS1 protein binds to KIR2DL2 promoter]; Azacitidine promotes the reaction [ETS1 protein binds to KIR2DL4 promoter] |
CTD |
PMID:18945643 |
|
NCBI chr 8:31,045,909...31,168,010
Ensembl chr 8:31,045,945...31,168,010
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G |
Eya1 |
EYA transcriptional coactivator and phosphatase 1 |
decreases expression |
ISO |
Azacitidine results in decreased expression of EYA1 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 5:4,863,501...5,101,483
Ensembl chr 5:4,955,543...5,101,483
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G |
Fads2 |
fatty acid desaturase 2 |
decreases expression |
ISO |
Azacitidine results in decreased expression of FADS2 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 1:206,707,384...206,747,333
Ensembl chr 1:206,708,783...206,748,789
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G |
Fam8a1 |
family with sequence similarity 8, member A1 |
increases expression |
ISO |
Azacitidine results in increased expression of FAM8A1 mRNA |
CTD |
PMID:19194470 |
|
NCBI chr17:18,026,601...18,035,509
Ensembl chr17:18,026,601...18,035,470
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G |
Faslg |
Fas ligand |
increases response to substance |
ISO |
Azacitidine results in increased susceptibility to FASLG protein |
CTD |
PMID:18829727 |
|
NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
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G |
Fbln1 |
fibulin 1 |
increases expression |
ISO |
Azacitidine results in increased expression of FBLN1 mRNA |
CTD |
PMID:21245298 |
|
NCBI chr 7:116,310,582...116,390,075
Ensembl chr 7:116,310,582...116,390,075
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G |
Fen1 |
flap structure-specific endonuclease 1 |
multiple interactions |
ISO |
[Azacitidine co-treated with Thalidomide] affects the expression of FEN1 mRNA |
CTD |
PMID:18720364 |
|
NCBI chr 1:206,845,126...206,849,821
Ensembl chr 1:206,844,884...206,850,003
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G |
Fgf7 |
fibroblast growth factor 7 |
decreases expression |
ISO |
Azacitidine results in decreased expression of FGF7 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 3:113,280,448...113,333,279
Ensembl chr 3:113,281,283...113,332,929
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G |
Filip1l |
filamin A interacting protein 1-like |
decreases expression |
ISO |
Azacitidine results in decreased expression of FILIP1L mRNA |
CTD |
PMID:20823114 |
|
NCBI chr11:42,937,353...43,177,085
Ensembl chr11:42,940,467...43,177,415
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G |
Foxo1 |
forkhead box O1 |
multiple interactions |
ISO |
[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate co-treated with Azacitidine] results in increased expression of FOXO1 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
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G |
Foxp3 |
forkhead box P3 |
multiple interactions |
ISO |
[Azacitidine co-treated with TGFB1 protein] results in increased expression of FOXP3 protein; [Azacitidine results in decreased methylation of FOXP3 gene] which results in increased expression of FOXP3 protein |
CTD |
PMID:18493985 |
|
NCBI chr X:14,908,494...14,924,994
Ensembl chr X:14,908,494...14,923,838
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G |
Ftl1 |
ferritin light chain 1 |
decreases expression |
EXP |
Azacitidine results in decreased expression of FTL1 protein |
CTD |
PMID:17105402 |
|
NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725 Ensembl chr10:95,936,387...95,939,725
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G |
Fyn |
FYN proto-oncogene, Src family tyrosine kinase |
increases expression |
ISO |
Azacitidine results in increased expression of FYN mRNA |
CTD |
PMID:21245298 |
|
NCBI chr20:42,767,733...42,960,903
Ensembl chr20:42,766,369...42,959,911
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G |
Gabrb1 |
gamma-aminobutyric acid type A receptor subunit beta1 |
increases expression |
ISO |
Azacitidine results in increased expression of GABRB1 mRNA |
CTD |
PMID:19194470 |
|
NCBI chr14:36,068,725...36,548,946
Ensembl chr14:36,080,393...36,548,948
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G |
Gadd45a |
growth arrest and DNA-damage-inducible, alpha |
decreases methylation multiple interactions increases expression |
ISO |
Azacitidine results in decreased methylation of GADD45A promoter [Azacitidine results in increased expression of GADD45A protein] which results in increased susceptibility to docetaxel Azacitidine results in increased expression of GADD45A mRNA; Azacitidine results in increased expression of GADD45A protein |
CTD |
PMID:19190346 |
|
NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
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G |
Gadd45b |
growth arrest and DNA-damage-inducible, beta |
multiple interactions |
ISO |
Azacitidine promotes the reaction [Depsipeptides results in increased expression of GADD45B] |
CTD |
PMID:18225533 |
|
NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046
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G |
Gata4 |
GATA binding protein 4 |
increases expression |
EXP |
Azacitidine results in increased expression of GATA4 mRNA; Azacitidine results in increased expression of GATA4 protein |
CTD |
PMID:18037191 |
|
NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636
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G |
Gbp2 |
guanylate binding protein 2 |
decreases expression |
ISO |
Azacitidine results in decreased expression of GBP2 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 2:231,332,488...231,348,573
Ensembl chr 2:231,332,284...231,348,571
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G |
Gcnt2 |
glucosaminyl (N-acetyl) transferase 2 |
decreases expression |
ISO |
Azacitidine results in decreased expression of GCNT2 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr17:23,796,859...23,901,625
Ensembl chr17:23,796,859...23,901,611
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G |
Gdf9 |
growth differentiation factor 9 |
increases expression |
ISO |
Azacitidine results in increased expression of GDF9 mRNA |
CTD |
PMID:23395740 |
|
NCBI chr10:37,589,200...37,599,970
Ensembl chr10:37,595,679...37,599,672
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G |
Gja1 |
gap junction protein, alpha 1 |
increases expression decreases expression |
EXP ISO |
Azacitidine results in increased expression of GJA1 protein Azacitidine results in decreased expression of GJA1 mRNA |
CTD |
PMID:18037191 PMID:20823114 |
|
NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
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G |
Gng7 |
G protein subunit gamma 7 |
affects methylation |
ISO |
Azacitidine affects the methylation of GNG7 promoter |
CTD |
PMID:18219292 |
|
NCBI chr 7:8,697,458...8,761,239
Ensembl chr 7:8,697,521...8,761,240
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G |
Gpkow |
G patch domain and KOW motifs |
increases expression |
ISO |
Azacitidine results in increased expression of GPKOW mRNA |
CTD |
PMID:20823114 |
|
NCBI chr X:14,791,601...14,806,384
Ensembl chr X:14,791,610...14,806,384
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G |
Gpnmb |
glycoprotein nmb |
decreases expression |
ISO |
Azacitidine results in decreased expression of GPNMB mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 4:78,010,247...78,031,491
Ensembl chr 4:78,010,197...78,049,367
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G |
Gpx3 |
glutathione peroxidase 3 |
increases expression |
ISO |
5-azacytidine increases expression of GPX3 mRNA in epithelial cells of stomach |
RGD |
PMID:16229808 |
RGD:151665354 |
NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035
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G |
Grin2b |
glutamate ionotropic receptor NMDA type subunit 2B |
decreases methylation |
ISO |
Azacitidine results in decreased methylation of GRIN2B gene |
CTD |
PMID:18618247 |
|
NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279
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G |
Guk1 |
guanylate kinase 1 |
increases expression |
ISO |
Azacitidine results in increased expression of GUK1 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr10:43,971,514...43,988,658
Ensembl chr10:43,971,509...43,980,107
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G |
Gzmb |
granzyme B |
multiple interactions |
ISO |
Azacitidine inhibits the reaction [IL2 protein results in increased secretion of GZMB protein] |
CTD |
PMID:19394699 |
|
NCBI chr15:30,343,352...30,346,814
Ensembl chr15:30,173,603...30,346,814
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G |
H1f0 |
H1.0 linker histone |
increases expression |
ISO |
Azacitidine results in increased expression of H1-0 protein |
CTD |
PMID:16006241 |
|
NCBI chr 7:110,592,834...110,594,694
Ensembl chr 7:110,592,208...110,594,694
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G |
H2ax |
H2A.X variant histone |
increases expression multiple interactions |
ISO EXP |
Azacitidine results in increased expression of H2AX protein Azacitidine inhibits the reaction [potassium bromate results in increased phosphorylation of H2AX protein] |
CTD |
PMID:17991895 PMID:25015661 |
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NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
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G |
H3f4 |
H3.4 histone, cluster member |
multiple interactions |
ISO |
Azacitidine promotes the reaction [H3-4 protein modified form binds to CCNA1 promoter] |
CTD |
PMID:17698632 |
|
NCBI chr10:43,740,702...43,741,262
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|
G |
Hgd |
homogentisate 1, 2-dioxygenase |
increases expression |
ISO |
Azacitidine results in increased expression of HGD mRNA |
CTD |
PMID:20823114 |
|
NCBI chr11:63,086,750...63,138,325
Ensembl chr11:63,086,752...63,138,323
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G |
Hgf |
hepatocyte growth factor |
increases expression |
ISO |
Azacitidine results in increased expression of HGF mRNA |
CTD |
PMID:19194470 |
|
NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
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G |
Hhex |
hematopoietically expressed homeobox |
increases expression |
ISO |
Azacitidine results in increased expression of HHEX mRNA |
CTD |
PMID:27590069 |
|
NCBI chr 1:235,190,455...235,196,042
Ensembl chr 1:235,190,455...235,196,042
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G |
Hmga1 |
high mobility group AT-hook 1 |
increases expression |
ISO |
Azacitidine results in increased expression of HMGA1 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr20:5,611,088...5,618,755
Ensembl chr20:5,611,694...5,618,752
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G |
Hmga2 |
high mobility group AT-hook 2 |
increases expression multiple interactions |
ISO |
Azacitidine results in increased expression of HMGA2 mRNA TP73 protein promotes the reaction [Azacitidine results in increased expression of HMGA2 mRNA] |
CTD |
PMID:21245298 |
|
NCBI chr 7:55,877,145...55,998,813
Ensembl chr 7:55,880,112...55,994,784
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G |
Hmgb1 |
high mobility group box 1 |
decreases expression multiple interactions |
ISO |
Azacitidine results in decreased expression of HMGB1 mRNA Azacitidine results in decreased expression of and results in increased secretion of HMGB1 protein; Bleomycin inhibits the reaction [Azacitidine results in decreased expression of and results in increased secretion of HMGB1 protein]; Bleomycin inhibits the reaction [Azacitidine results in decreased expression of HMGB1 mRNA] |
CTD |
PMID:32278510 |
|
NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565 Ensembl chr16:5,901,586...5,978,565
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G |
Hnf1a |
HNF1 homeobox A |
decreases methylation multiple interactions increases expression |
ISO |
Azacitidine results in decreased methylation of HNF1A promoter HNF1A mutant form inhibits the reaction [Azacitidine results in increased expression of AQP9 mRNA] Azacitidine results in increased expression of HNF1A mRNA; Azacitidine results in increased expression of HNF1A protein |
CTD |
PMID:25953102 |
|
NCBI chr12:41,638,536...41,672,806
Ensembl chr12:41,645,587...41,672,104
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G |
Hnf4a |
hepatocyte nuclear factor 4, alpha |
increases expression |
ISO |
Azacitidine results in increased expression of HNF4A mRNA |
CTD |
PMID:27590069 |
|
NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320
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G |
Hoxa1 |
homeobox A1 |
multiple interactions increases expression |
ISO |
Azacitidine inhibits the reaction [[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of HOXA1 mRNA] Azacitidine results in increased expression of HOXA1 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 4:81,255,814...81,258,587
Ensembl chr 4:81,255,883...81,258,504
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G |
Hpgd |
15-hydroxyprostaglandin dehydrogenase |
decreases methylation multiple interactions increases expression |
ISO |
Azacitidine results in decreased methylation of HPGD gene trichostatin A promotes the reaction [Azacitidine results in increased expression of HPGD mRNA] |
CTD |
PMID:19584167 |
|
NCBI chr16:33,986,265...34,024,228
Ensembl chr16:33,986,266...34,024,228
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G |
Hsd3b1 |
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 |
affects expression |
ISO |
Azacitidine affects the expression of HSD3B1 mRNA |
CTD |
PMID:18033690 |
|
NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999
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G |
Hsf1 |
heat shock transcription factor 1 |
decreases activity |
ISO |
Azacitidine results in decreased activity of HSF1 protein |
CTD |
PMID:34170685 |
|
NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
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G |
Hspa6l-ps1 |
heat shock protein family A (Hsp70) member 6 like, pseudogene 1 |
increases expression |
ISO |
Azacitidine results in increased expression of HSPA6 mRNA |
CTD |
PMID:19194470 |
|
NCBI chr13:83,273,176...83,274,317
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G |
Id1 |
inhibitor of DNA binding 1 |
increases expression |
ISO |
Azacitidine results in increased expression of ID1 mRNA |
CTD |
PMID:19194470 |
|
NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419
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G |
Id3 |
inhibitor of DNA binding 3 |
increases expression |
ISO |
Azacitidine results in increased expression of ID3 mRNA |
CTD |
PMID:19194470 |
|
NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349
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G |
Ifng |
interferon gamma |
multiple interactions |
ISO |
[Azacitidine promotes the reaction [IFNG protein results in increased expression of CIITA mRNA]] which results in increased expression of HLA-DRA protein; [Azacitidine results in decreased methylation of CIITA promoter] promotes the reaction [IFNG protein results in increased expression of CIITA mRNA]; [Azacitidine results in increased expression of KIR2DL4 protein] which results in increased secretion of IFNG protein |
CTD |
PMID:18829986 PMID:18945643 |
|
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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G |
Igfbp1 |
insulin-like growth factor binding protein 1 |
multiple interactions increases expression |
ISO |
Azacitidine inhibits the reaction [[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of IGFBP1 mRNA]; Azacitidine promotes the reaction [[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of IGFBP1 protein] Azacitidine results in increased expression of IGFBP1 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482
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G |
Igfbp4 |
insulin-like growth factor binding protein 4 |
increases expression |
ISO |
Azacitidine results in increased expression of IGFBP4 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr10:83,995,253...84,007,272
Ensembl chr10:83,989,591...84,007,225
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G |
Il12b |
interleukin 12B |
increases expression |
ISO |
Azacitidine results in increased expression of IL12B mRNA |
CTD |
PMID:20823114 |
|
NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
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G |
Il1b |
interleukin 1 beta |
increases expression multiple interactions |
EXP ISO |
Azacitidine results in increased expression of IL1B mRNA Azacitidine inhibits the reaction [Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of CD274 mRNA]]; Azacitidine inhibits the reaction [Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of CD274 protein]] |
CTD |
PMID:17156202 PMID:32894642 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il2 |
interleukin 2 |
multiple interactions |
ISO |
Azacitidine inhibits the reaction [IL2 protein results in increased secretion of GZMB protein]; Azacitidine inhibits the reaction [IL2 protein results in increased secretion of PRF1 protein] |
CTD |
PMID:19394699 |
|
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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G |
Il4 |
interleukin 4 |
affects methylation |
ISO |
Azacitidine affects the methylation of IL4 promoter |
CTD |
PMID:18158872 |
|
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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|
G |
Il6 |
interleukin 6 |
affects secretion affects methylation |
ISO |
Azacitidine affects the secretion of IL6 protein Azacitidine affects the methylation of IL6 promoter |
CTD |
PMID:18158872 PMID:18443271 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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|
G |
Il6r |
interleukin 6 receptor |
affects expression multiple interactions |
ISO |
[Azacitidine affects the expression of IL6R protein] which affects the expression of BCL2L1 protein; Azacitidine affects the expression of IL6R mRNA [Azacitidine affects the expression of IL6R protein] which affects the phosphorylation of STAT3 protein |
CTD |
PMID:18443271 |
|
NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536
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|
G |
Isca1 |
iron-sulfur cluster assembly 1 |
increases expression |
ISO |
Azacitidine results in increased expression of ISCA1 mRNA |
CTD |
PMID:19194470 |
|
NCBI chr17:4,905,291...4,917,955
Ensembl chr17:4,905,287...4,917,955
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|
G |
Itgb1 |
integrin subunit beta 1 |
decreases expression |
ISO |
Azacitidine results in decreased expression of ITGB1 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
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G |
Itgb2 |
integrin subunit beta 2 |
decreases expression |
ISO |
Azacitidine results in decreased expression of ITGB2 mRNA |
CTD |
PMID:19194470 |
|
NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600
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G |
Itprid2 |
ITPR interacting domain containing 2 |
increases expression |
ISO |
Azacitidine results in increased expression of ITPRID2 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 3:64,536,707...64,573,978
Ensembl chr 3:64,536,707...64,573,978
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G |
Kdr |
kinase insert domain receptor |
increases expression |
EXP |
Azacitidine results in increased expression of KDR mRNA |
CTD |
PMID:18037191 |
|
NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
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|
G |
Kif2c |
kinesin family member 2C |
multiple interactions |
ISO |
[Azacitidine co-treated with Thalidomide] affects the expression of KIF2C mRNA |
CTD |
PMID:18720364 |
|
NCBI chr 5:130,637,347...130,662,680
Ensembl chr 5:130,637,347...130,662,637
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|
G |
Kir3dl1 |
killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1 |
increases expression decreases methylation |
ISO |
Azacitidine results in increased expression of KIR3DL1 mRNA; Azacitidine results in increased expression of KIR3DL1 protein Azacitidine results in decreased methylation of KIR3DL1 promoter |
CTD |
PMID:18945643 PMID:19394699 |
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NCBI chr 1:69,715,529...69,754,050
Ensembl chr 1:69,715,535...69,754,050
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G |
Klf6 |
KLF transcription factor 6 |
increases expression multiple interactions |
ISO |
Azacitidine results in increased expression of KLF6 mRNA TP73 protein promotes the reaction [Azacitidine results in increased expression of KLF6 mRNA] |
CTD |
PMID:21245298 |
|
NCBI chr17:64,539,456...64,548,451
Ensembl chr17:64,531,463...64,588,570
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G |
Klk1c10 |
kallikrein 1-related peptidase C10 |
increases expression |
ISO |
Azacitidine analog results in increased expression of KLK3 protein |
CTD |
PMID:18324645 |
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NCBI chr 1:94,402,993...94,407,052
Ensembl chr 1:94,402,993...94,407,052
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G |
Krt19 |
keratin 19 |
increases expression |
ISO |
Azacitidine results in increased expression of KRT19 mRNA |
CTD |
PMID:20823114 |
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NCBI chr10:85,075,835...85,080,552
Ensembl chr10:85,066,802...85,171,799
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G |
Krt32 |
keratin 32 |
increases expression |
ISO |
Azacitidine results in increased expression of KRT32 mRNA |
CTD |
PMID:20823114 |
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NCBI chr10:85,013,551...85,020,578
Ensembl chr10:85,013,554...85,020,534
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G |
Krt8 |
keratin 8 |
multiple interactions increases expression |
ISO |
Azacitidine inhibits the reaction [[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of KRT8 mRNA] Azacitidine results in increased expression of KRT8 mRNA |
CTD |
PMID:20823114 |
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NCBI chr 7:133,124,203...133,131,656
Ensembl chr 7:133,124,203...133,131,728
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G |
Lama1 |
laminin subunit alpha 1 |
affects localization |
ISO |
Azacitidine affects the localization of LAMA1 protein |
CTD |
PMID:18033690 |
|
NCBI chr 9:107,692,770...107,816,847
Ensembl chr 9:107,692,770...107,817,478
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G |
Lamb2 |
laminin subunit beta 2 |
increases expression |
ISO |
Azacitidine results in increased expression of LAMB2 mRNA |
CTD |
PMID:20823114 |
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NCBI chr 8:109,178,367...109,190,552
Ensembl chr 8:109,178,409...109,190,549
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G |
Ldhb |
lactate dehydrogenase B |
increases expression |
ISO |
Azacitidine results in increased expression of LDHB mRNA |
CTD |
PMID:23437403 |
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NCBI chr 4:175,428,382...175,446,403
Ensembl chr 4:175,428,385...175,446,403
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G |
Lims1 |
LIM zinc finger domain containing 1 |
increases expression |
ISO |
Azacitidine results in increased expression of LIMS1 mRNA |
CTD |
PMID:19194470 |
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NCBI chr20:26,309,833...26,418,511
Ensembl chr20:26,309,895...26,418,500
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G |
Litaf |
lipopolysaccharide-induced TNF factor |
decreases expression |
ISO |
Azacitidine results in decreased expression of LITAF mRNA |
CTD |
PMID:19194470 |
|
NCBI chr10:4,656,308...4,692,981
Ensembl chr10:4,625,552...4,692,763
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G |
Ltb4r |
leukotriene B4 receptor |
decreases expression |
ISO |
Azacitidine results in decreased expression of LTB4R mRNA |
CTD |
PMID:20823114 |
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NCBI chr15:29,263,199...29,265,716
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G |
Lyz2 |
lysozyme 2 |
increases expression |
ISO |
Azacitidine results in increased expression of LYZ mRNA |
CTD |
PMID:19194470 |
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NCBI chr 7:52,906,810...52,912,154
Ensembl chr 7:52,906,811...52,912,106
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G |
Mad1l1 |
mitotic arrest deficient 1 like 1 |
decreases expression |
ISO |
Azacitidine results in decreased expression of MAD1L1 mRNA |
CTD |
PMID:19194470 |
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NCBI chr12:14,320,892...14,630,750
Ensembl chr12:14,320,892...14,630,703
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G |
Mafb |
MAF bZIP transcription factor B |
increases expression multiple interactions |
ISO |
Azacitidine results in increased expression of MAFB mRNA Cisplatin affects the reaction [Azacitidine results in increased expression of MAFB mRNA] |
CTD |
PMID:36336710 |
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NCBI chr 3:148,998,111...149,000,031
Ensembl chr 3:148,998,122...149,000,031
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G |
Map1a |
microtubule-associated protein 1A |
decreases expression |
ISO |
Azacitidine results in decreased expression of MAP1A mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 3:108,263,217...108,283,936
Ensembl chr 3:108,263,151...108,282,899
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G |
Map2k5 |
mitogen activated protein kinase kinase 5 |
decreases expression |
ISO |
Azacitidine results in decreased expression of MAP2K5 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 8:63,625,220...63,852,090
Ensembl chr 8:63,625,221...63,851,983
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G |
Mapt |
microtubule-associated protein tau |
decreases expression |
ISO |
Azacitidine results in decreased expression of MAPT protein |
CTD |
PMID:16930453 |
|
NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
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G |
Mcl1 |
MCL1 apoptosis regulator, BCL2 family member |
decreases expression |
ISO |
5-azacytidine decreases expression of MCL1 protein in lung cancer cells |
RGD |
PMID:24356455 |
RGD:153344603 |
NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
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G |
Mcm5 |
minichromosome maintenance complex component 5 |
multiple interactions |
ISO |
[Azacitidine co-treated with Thalidomide] affects the expression of MCM5 mRNA |
CTD |
PMID:18720364 |
|
NCBI chr19:13,483,030...13,504,389
Ensembl chr19:13,483,066...13,504,389
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G |
Mdc1 |
mediator of DNA damage checkpoint 1 |
increases expression |
ISO |
Azacitidine results in increased expression of MDC1 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr20:2,893,693...2,912,394
Ensembl chr20:2,895,505...2,910,240
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G |
Mdm2 |
MDM2 proto-oncogene |
increases expression |
ISO |
Azacitidine results in increased expression of MDM2 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
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G |
Mecp2 |
methyl CpG binding protein 2 |
multiple interactions |
ISO |
Azacitidine inhibits the reaction [MECP2 protein binds to CCNA1 promoter] |
CTD |
PMID:17698632 |
|
NCBI chr X:151,781,177...151,844,687
Ensembl chr X:151,789,930...151,844,689
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G |
Mef2a |
myocyte enhancer factor 2a |
increases expression affects expression |
ISO |
Azacitidine results in increased expression of MEF2A Azacitidine affects the expression of MEF2A protein |
CTD |
PMID:12094073 PMID:19002953 |
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NCBI chr 1:120,847,874...120,982,488
Ensembl chr 1:120,850,080...120,981,948
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G |
Mef2d |
myocyte enhancer factor 2D |
affects expression increases expression |
ISO |
Azacitidine affects the expression of MEF2D protein Azacitidine results in increased expression of MEF2D |
CTD |
PMID:12094073 PMID:19002953 |
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NCBI chr 2:173,606,054...173,635,620
Ensembl chr 2:173,606,490...173,634,457
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G |
Megf6 |
multiple EGF-like-domains 6 |
decreases expression |
ISO |
Azacitidine results in decreased expression of MEGF6 mRNA |
CTD |
PMID:19194470 |
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NCBI chr 5:164,738,272...164,839,142
Ensembl chr 5:164,738,352...164,839,139
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G |
Mesd |
mesoderm development LRP chaperone |
decreases expression |
EXP |
Azacitidine results in decreased expression of MESD protein |
CTD |
PMID:17105402 |
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NCBI chr 1:137,866,707...137,879,999
Ensembl chr 1:137,874,242...137,879,999
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G |
Mfap2 |
microfibril associated protein 2 |
decreases expression |
ISO |
Azacitidine results in decreased expression of MFAP2 mRNA |
CTD |
PMID:20823114 |
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NCBI chr 5:153,312,068...153,320,266
Ensembl chr 5:153,314,711...153,320,259
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G |
Mfge8 |
milk fat globule EGF and factor V/VIII domain containing |
affects expression |
ISO |
Azacitidine affects the expression of MFGE8 mRNA |
CTD |
PMID:18033690 |
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NCBI chr 1:133,064,665...133,080,069
Ensembl chr 1:133,064,665...133,080,073
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G |
Mgmt |
O-6-methylguanine-DNA methyltransferase |
increases expression decreases methylation |
ISO |
Azacitidine results in increased expression of MGMT mRNA Azacitidine results in decreased methylation of MGMT protein |
CTD |
PMID:7511991 PMID:12807730 |
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NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756
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G |
Mir193a |
microRNA 193a |
increases expression |
ISO |
5-azacytidine increases expression of MIR193A in liver cells 5-azacytidine increases expression of MIR193a RNA in lung cancer cells |
RGD |
PMID:28036298 PMID:24356455 |
RGD:153344564, RGD:153344603 |
NCBI chr10:64,672,343...64,672,454
Ensembl chr10:64,672,343...64,672,454
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G |
Mir23b |
microRNA 23b |
increases expression |
ISO |
5-azacytidine increases expression of MIR23B miRNA in liver cells |
RGD |
PMID:28036298 |
RGD:153344564 |
NCBI chr17:1,813,667...1,813,763
Ensembl chr17:1,813,667...1,813,763
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G |
Mir497 |
microRNA 497 |
increases expression multiple interactions decreases methylation |
ISO |
Azacitidine results in increased expression of MIR497 mRNA Azacitidine inhibits the reaction [DNMT1 protein binds to MIR497 promoter]; Azacitidine inhibits the reaction [DNMT3A protein binds to MIR497 promoter]; Azacitidine inhibits the reaction [DNMT3B protein binds to MIR497 promoter] Azacitidine results in decreased methylation of MIR497 promoter |
CTD |
PMID:35066776 |
|
NCBI chr10:54,951,514...54,951,582
Ensembl chr10:54,951,505...54,951,584
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G |
Mir9-3 |
microRNA 9-3 |
increases expression |
ISO |
5-azacytidine increases expression of MIR9-3 in lung cancer cells |
RGD |
PMID:24356455 |
RGD:153344603 |
NCBI chr 1:133,440,049...133,440,138
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G |
Mki67 |
marker of proliferation Ki-67 |
multiple interactions |
ISO |
[Azacitidine co-treated with Thalidomide] affects the expression of MKI67 mRNA |
CTD |
PMID:18720364 |
|
NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
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G |
Mmp1 |
matrix metallopeptidase 1 |
increases expression |
ISO |
Azacitidine results in increased expression of MMP1 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
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G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions |
ISO |
metacept-1 inhibits the reaction [Azacitidine results in increased expression of MMP9] |
CTD |
PMID:19148494 |
|
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Morf4l2 |
mortality factor 4 like 2 |
decreases expression |
ISO |
Azacitidine results in decreased expression of MORF4L2 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr X:100,082,562...100,093,658
Ensembl chr X:100,082,404...100,093,728
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G |
Mov10l1 |
Mov10 like RNA helicase 1 |
increases expression |
ISO |
Azacitidine results in increased expression of MOV10L1 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 7:120,070,171...120,135,406
Ensembl chr 7:120,070,135...120,134,765
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G |
Msrb2 |
methionine sulfoxide reductase B2 |
increases expression |
ISO |
Azacitidine results in increased expression of MSRB2 mRNA |
CTD |
PMID:19194470 |
|
NCBI chr17:81,974,378...82,000,044
Ensembl chr17:81,974,196...82,000,043
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G |
Mthfd2 |
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase |
decreases expression |
ISO |
Azacitidine results in decreased expression of MTHFD2 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 4:115,811,135...115,822,663
Ensembl chr 4:115,811,139...115,822,608
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G |
Mtrex |
Mtr4 exosome RNA helicase |
increases expression |
ISO |
Azacitidine results in increased expression of MTREX mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 2:44,500,326...44,560,624
Ensembl chr 2:44,461,444...44,560,627
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G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
decreases expression multiple interactions |
ISO |
Azacitidine analog results in decreased expression of MYC mRNA MYC protein affects the reaction [Azacitidine results in decreased activity of TERT protein]; MYC protein affects the reaction [Azacitidine results in decreased expression of TERT mRNA] |
CTD |
PMID:18045574 PMID:19451745 |
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NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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G |
Myf5 |
myogenic factor 5 |
increases expression |
ISO |
Azacitidine results in increased expression of MYF5 mRNA |
CTD |
PMID:18938140 |
|
NCBI chr 7:42,802,946...42,806,177
Ensembl chr 7:42,802,946...42,806,177
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G |
Myh7 |
myosin heavy chain 7 |
increases expression |
EXP |
Azacitidine results in increased expression of MYH7 mRNA; Azacitidine results in increased expression of MYH7 protein |
CTD |
PMID:17105402 |
|
NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217
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G |
Myl2 |
myosin light chain 2 |
increases expression |
EXP |
Azacitidine results in increased expression of MYL2 mRNA |
CTD |
PMID:17105402 |
|
NCBI chr12:34,454,223...34,468,554
Ensembl chr12:34,454,218...34,468,983
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G |
Myod1 |
myogenic differentiation 1 |
increases expression |
EXP ISO |
Azacitidine results in increased expression of MYOD1 mRNA |
CTD |
PMID:18037191 PMID:18938140 |
|
NCBI chr 1:96,884,864...96,887,574
Ensembl chr 1:96,884,948...96,887,554
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G |
Myog |
myogenin |
increases expression |
ISO |
Azacitidine results in increased expression of MYOG mRNA |
CTD |
PMID:18938140 |
|
NCBI chr13:45,745,455...45,748,044
Ensembl chr13:45,745,436...45,748,039
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G |
Ncam1 |
neural cell adhesion molecule 1 |
increases expression |
EXP |
Azacitidine results in increased expression of NCAM1 mRNA |
CTD |
PMID:18037191 |
|
NCBI chr 8:49,865,629...50,165,687
Ensembl chr 8:49,865,633...50,166,014
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G |
Nefl |
neurofilament light chain |
increases expression |
ISO |
Azacitidine results in increased expression of NEFL mRNA |
CTD |
PMID:20823114 |
|
NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793
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G |
Nfatc1 |
nuclear factor of activated T-cells 1 |
increases expression |
ISO |
Azacitidine results in increased expression of NFATC1 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr18:74,046,422...74,156,041
Ensembl chr18:74,046,904...74,156,028
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G |
Niban1 |
niban apoptosis regulator 1 |
increases expression multiple interactions |
ISO |
Azacitidine results in increased expression of NIBAN1 mRNA TP73 protein promotes the reaction [Azacitidine results in increased expression of NIBAN1 mRNA] |
CTD |
PMID:21245298 |
|
NCBI chr13:63,674,240...63,827,748
Ensembl chr13:63,674,171...63,827,729
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G |
Nkx2-5 |
NK2 homeobox 5 |
increases expression |
ISO |
Azacitidine results in increased expression of NKX2-5 mRNA |
CTD |
PMID:18557828 |
|
NCBI chr10:16,340,428...16,347,004
Ensembl chr10:16,344,159...16,346,934
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G |
Nlgn3 |
neuroligin 3 |
increases expression |
ISO |
Azacitidine results in increased expression of NLGN3 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr X:66,427,926...66,457,378
Ensembl chr X:66,429,458...66,451,876
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G |
Nme2 |
NME/NM23 nucleoside diphosphate kinase 2 |
increases expression |
EXP |
Azacitidine results in increased expression of NME2 protein |
CTD |
PMID:17105402 |
|
NCBI chr10:78,898,097...78,903,514
Ensembl chr10:78,897,770...78,903,538
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G |
Nmi |
N-myc (and STAT) interactor |
increases expression |
ISO |
Azacitidine results in increased expression of NMI mRNA |
CTD |
PMID:21245298 |
|
NCBI chr 3:36,415,607...36,439,716
Ensembl chr 3:36,415,607...36,439,498
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G |
Nnt |
nicotinamide nucleotide transhydrogenase |
increases expression |
ISO |
Azacitidine results in increased expression of NNT mRNA; Azacitidine results in increased expression of NNT protein |
CTD |
PMID:36336710 |
|
NCBI chr 2:51,411,413...51,505,125
Ensembl chr 2:51,411,413...51,504,823
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G |
Nom1 |
nucleolar protein with MIF4G domain 1 |
decreases expression |
ISO |
Azacitidine results in decreased expression of NOM1 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 4:5,891,220...5,910,741
Ensembl chr 4:5,892,909...5,909,709
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G |
Nphp1 |
nephrocystin 1 |
increases expression |
ISO |
Azacitidine results in increased expression of NPHP1 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 3:114,960,650...115,016,234
Ensembl chr 3:114,960,650...115,016,234
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G |
Nppa |
natriuretic peptide A |
increases expression |
ISO |
Azacitidine results in increased expression of NPPA |
CTD |
PMID:15005238 |
|
NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
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G |
Nppb |
natriuretic peptide B |
increases expression |
ISO |
Azacitidine results in increased expression of NPPB |
CTD |
PMID:15005238 |
|
NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
|
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
multiple interactions |
ISO |
[Azacitidine co-treated with Butyrates] inhibits the reaction [Chromium inhibits the reaction [Benzo(a)pyrene results in increased expression of NQO1 mRNA]]; Azacitidine inhibits the reaction [Chromium inhibits the reaction [Benzo(a)pyrene results in increased expression of NQO1 mRNA]] |
CTD |
PMID:17682057 |
|
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
|
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G |
Nr4a1 |
nuclear receptor subfamily 4, group A, member 1 |
multiple interactions |
ISO |
[metacept-1 co-treated with Azacitidine] results in increased expression of NR4A1 |
CTD |
PMID:19148494 |
|
NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297
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G |
Nrip1 |
nuclear receptor interacting protein 1 |
decreases expression |
ISO |
Azacitidine results in decreased expression of NRIP1 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr11:14,895,843...14,979,490
Ensembl chr11:14,895,553...14,981,761
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G |
Nrn1 |
neuritin 1 |
decreases expression |
ISO |
Azacitidine results in decreased expression of NRN1 mRNA |
CTD |
PMID:19194470 |
|
NCBI chr17:28,129,969...28,138,898
Ensembl chr17:28,129,977...28,138,896
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G |
Nt5e |
5' nucleotidase, ecto |
increases expression |
ISO |
Azacitidine results in increased expression of NT5E mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 8:89,271,046...89,314,918
Ensembl chr 8:89,270,696...89,314,881
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G |
Nts |
neurotensin |
decreases expression |
ISO |
Azacitidine results in decreased expression of NTS mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 7:37,564,944...37,574,350
Ensembl chr 7:37,564,533...37,574,423
|
|
G |
Nusap1 |
nucleolar and spindle associated protein 1 |
multiple interactions |
ISO |
[Azacitidine co-treated with Thalidomide] affects the expression of NUSAP1 mRNA |
CTD |
PMID:18720364 |
|
NCBI chr 3:106,603,273...106,633,428
Ensembl chr 3:106,603,289...106,633,624
|
|
G |
Nxt2 |
nuclear transport factor 2-like export factor 2 |
increases expression |
ISO |
Azacitidine results in increased expression of NXT2 mRNA |
CTD |
PMID:19194470 |
|
NCBI chr X:105,855,616...105,862,902
Ensembl chr X:105,855,608...105,862,899
|
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G |
Ocln |
occludin |
increases expression |
ISO |
Azacitidine results in increased expression of OCLN mRNA |
CTD |
PMID:18661270 |
|
NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150
|
|
G |
Ogfrl1 |
opioid growth factor receptor-like 1 |
increases expression |
ISO |
Azacitidine results in increased expression of OGFRL1 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 9:25,828,865...25,842,424
Ensembl chr 9:25,828,869...25,842,352
|
|
G |
Ogg1 |
8-oxoguanine DNA glycosylase |
decreases expression decreases methylation |
ISO |
Azacitidine results in decreased expression of OGG1 protein Azacitidine results in decreased methylation of OGG1 promoter |
CTD |
PMID:22064374 |
|
NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766
|
|
G |
Or8b8 |
olfactory receptor family 8 subfamily B member 8 |
increases expression |
ISO |
Azacitidine results in increased expression of OR8B8 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 8:37,693,578...37,694,510
Ensembl chr 8:37,693,499...37,694,547
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G |
Oxr1 |
oxidation resistance 1 |
increases expression |
ISO |
Azacitidine results in increased expression of OXR1 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 7:72,528,750...72,965,666
Ensembl chr 7:72,528,786...72,965,666
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G |
Oxtr |
oxytocin receptor |
decreases expression |
ISO |
Azacitidine results in decreased expression of OXTR mRNA |
CTD |
PMID:21245298 |
|
NCBI chr 4:145,598,549...145,614,674
Ensembl chr 4:145,599,561...145,614,674
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G |
P4hb |
prolyl 4-hydroxylase subunit beta |
increases expression |
EXP ISO |
Azacitidine results in increased expression of P4HB protein Azacitidine results in increased expression of P4HB mRNA |
CTD |
PMID:17105402 PMID:20823114 |
|
NCBI chr10:105,836,972...105,848,583
Ensembl chr10:105,836,982...105,848,500
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G |
Paep |
progestagen associated endometrial protein |
decreases expression |
ISO |
Azacitidine results in decreased expression of PAEP mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 3:8,531,136...8,534,430
Ensembl chr 3:8,531,138...8,534,430
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G |
Pak1 |
p21 (RAC1) activated kinase 1 |
increases expression |
ISO |
Azacitidine results in increased expression of PAK1 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 1:152,111,172...152,226,390
Ensembl chr 1:152,111,188...152,226,383
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G |
Pank3 |
pantothenate kinase 3 |
decreases expression |
ISO |
Azacitidine results in decreased expression of PANK3 mRNA |
CTD |
PMID:19194470 |
|
NCBI chr10:20,229,129...20,252,955
Ensembl chr10:20,229,129...20,252,955
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases cleavage multiple interactions |
ISO |
Azacitidine results in increased cleavage of PARP1 protein Bleomycin inhibits the reaction [Azacitidine results in increased cleavage of PARP1 protein] |
CTD |
PMID:32278510 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Pax4 |
paired box 4 |
increases expression |
ISO |
Azacitidine results in increased expression of PAX4 mRNA |
CTD |
PMID:18949370 |
|
NCBI chr 4:57,058,453...57,065,995
Ensembl chr 4:57,058,462...57,063,408
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G |
Pcdh18 |
protocadherin 18 |
decreases expression |
ISO |
Azacitidine results in decreased expression of PCDH18 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 2:133,831,996...133,845,992
Ensembl chr 2:133,832,001...133,845,883
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G |
Pcdha1 |
protocadherin alpha 1 |
affects methylation |
ISO |
Azacitidine affects the methylation of PCDHA1 promoter |
CTD |
PMID:18204046 |
|
Ensembl chr18:28,581,225...28,846,211
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|
G |
Pcdha10 |
protocadherin alpha 10 |
affects methylation |
ISO |
Azacitidine affects the methylation of PCDHA10 promoter |
CTD |
PMID:18204046 |
|
Ensembl chr18:28,581,225...28,846,211
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|
G |
Pcdha11 |
protocadherin alpha 11 |
affects methylation |
ISO |
Azacitidine affects the methylation of PCDHA11 promoter |
CTD |
PMID:18204046 |
|
Ensembl chr18:28,581,225...28,846,211
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|
G |
Pcdha12 |
protocadherin alpha 12 |
affects methylation |
ISO |
Azacitidine affects the methylation of PCDHA12 promoter |
CTD |
PMID:18204046 |
|
Ensembl chr18:28,581,225...28,846,211
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|
G |
Pcdha2 |
protocadherin alpha 2 |
affects methylation |
ISO |
Azacitidine affects the methylation of PCDHA2 promoter |
CTD |
PMID:18204046 |
|
Ensembl chr18:28,581,225...28,846,211
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|
G |
Pcdha3 |
protocadherin alpha 3 |
affects methylation |
ISO |
Azacitidine affects the methylation of PCDHA3 promoter |
CTD |
PMID:18204046 |
|
Ensembl chr18:28,581,225...28,846,211
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|
G |
Pcdha4 |
protocadherin alpha 4 |
affects methylation |
ISO |
Azacitidine affects the methylation of PCDHA4 promoter |
CTD |
PMID:18204046 |
|
NCBI chr18:28,581,040...28,846,214
Ensembl chr18:28,581,225...28,846,211
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G |
Pcdha5 |
protocadherin alpha 5 |
affects methylation |
ISO |
Azacitidine affects the methylation of PCDHA5 promoter |
CTD |
PMID:18204046 |
|
Ensembl chr18:28,581,225...28,846,211
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|
G |
Pcdha6 |
protocadherin alpha 6 |
affects methylation |
ISO |
Azacitidine affects the methylation of PCDHA6 promoter |
CTD |
PMID:18204046 |
|
Ensembl chr18:28,581,225...28,846,211
|
|
G |
Pcdha7 |
protocadherin alpha 7 |
affects methylation |
ISO |
Azacitidine affects the methylation of PCDHA7 promoter |
CTD |
PMID:18204046 |
|
Ensembl chr18:28,581,225...28,846,211
|
|
G |
Pcdha9 |
protocadherin alpha 9 |
affects methylation |
ISO |
Azacitidine affects the methylation of PCDHA8 promoter; Azacitidine affects the methylation of PCDHA9 promoter |
CTD |
PMID:18204046 |
|
Ensembl chr18:28,581,225...28,846,211
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|
G |
Pcdhb20 |
protocadherin beta 20 |
decreases expression |
ISO |
Azacitidine results in decreased expression of PCDHB14 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr18:29,211,878...29,215,272
Ensembl chr18:29,211,883...29,215,258
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G |
Pcdhb5 |
protocadherin beta 5 |
decreases expression |
ISO |
Azacitidine results in decreased expression of PCDHB4 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr18:29,024,315...29,032,183
Ensembl chr18:29,028,382...29,053,259
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G |
Pcna |
proliferating cell nuclear antigen |
decreases expression multiple interactions |
EXP |
Azacitidine results in decreased expression of PCNA protein [Cisplatin co-treated with Azacitidine] results in decreased expression of PCNA protein |
CTD |
PMID:19723570 |
|
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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G |
Pdk1 |
pyruvate dehydrogenase kinase 1 |
increases expression |
ISO |
Azacitidine results in increased expression of PDK1 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038
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G |
Pdk4 |
pyruvate dehydrogenase kinase 4 |
increases expression decreases methylation |
ISO |
Azacitidine results in increased expression of PDK4 protein Azacitidine results in decreased methylation of PDK4 promoter |
CTD |
PMID:28003426 |
|
NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850
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G |
Pecam1 |
platelet and endothelial cell adhesion molecule 1 |
increases expression |
EXP |
Azacitidine results in increased expression of PECAM1 mRNA |
CTD |
PMID:18037191 |
|
NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116
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G |
Pfn1 |
profilin 1 |
increases expression |
ISO |
Azacitidine results in increased expression of PFN1 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr10:55,365,263...55,367,968
Ensembl chr10:55,365,262...55,527,631
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G |
Phactr2 |
phosphatase and actin regulator 2 |
increases expression |
ISO |
Azacitidine results in increased expression of PHACTR2 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 1:7,591,254...7,860,431
Ensembl chr 1:7,597,927...7,860,289
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G |
Pip5k1a |
phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha |
decreases expression |
ISO |
Azacitidine results in decreased expression of PIP5K1A mRNA |
CTD |
PMID:19194470 |
|
NCBI chr 2:182,628,299...182,671,584
Ensembl chr 2:182,628,300...182,671,598
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G |
Pitpnc1 |
phosphatidylinositol transfer protein, cytoplasmic 1 |
decreases expression |
ISO |
Azacitidine results in decreased expression of PITPNC1 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr10:92,163,558...92,428,971
Ensembl chr10:92,167,196...92,429,297
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G |
Pitx3 |
paired-like homeodomain 3 |
increases expression |
EXP |
Azacitidine results in increased expression of PITX3 mRNA |
CTD |
PMID:27415467 |
|
NCBI chr 1:245,001,106...245,013,881
Ensembl chr 1:245,001,164...245,013,892
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G |
Pja1 |
praja ring finger ubiquitin ligase 1 |
increases expression |
ISO |
Azacitidine results in increased expression of PJA1 mRNA |
CTD |
PMID:19194470 |
|
NCBI chr X:64,580,938...64,585,846
Ensembl chr X:64,580,849...64,585,833
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G |
Pkd2l1 |
polycystin 2 like 1, transient receptor potential cation channel |
increases expression |
ISO |
Azacitidine results in increased expression of PKD2L1 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 1:243,032,891...243,070,031
Ensembl chr 1:243,032,913...243,070,031
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G |
Pkm |
pyruvate kinase M1/2 |
increases expression |
ISO |
Azacitidine results in increased expression of PKM mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599
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G |
Plcb1 |
phospholipase C beta 1 |
decreases methylation decreases response to substance increases response to substance increases expression |
ISO |
Azacitidine results in decreased methylation of PLCB1 promoter PLCB1 promoter modified form results in decreased susceptibility to Azacitidine PLCB1 mRNA results in increased susceptibility to Azacitidine; PLCB1 protein results in increased susceptibility to Azacitidine Azacitidine results in increased expression of PLCB1 mRNA; Azacitidine results in increased expression of PLCB1 protein |
CTD |
PMID:19805378 |
|
NCBI chr 3:122,059,988...122,772,896
Ensembl chr 3:122,060,031...122,772,869
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G |
Plpp1 |
phospholipid phosphatase 1 |
increases expression |
ISO |
Azacitidine results in increased expression of PLPP1 mRNA |
CTD |
PMID:19194470 |
|
NCBI chr 2:44,439,002...44,500,430
Ensembl chr 2:44,438,994...44,501,268
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G |
Pls3 |
plastin 3 |
decreases expression |
ISO |
Azacitidine results in decreased expression of PLS3 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr X:111,589,193...111,683,908
Ensembl chr X:111,589,254...111,683,891
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G |
Pml |
PML nuclear body scaffold |
increases expression |
ISO |
Azacitidine results in increased expression of PML mRNA |
CTD |
PMID:19194470 |
|
NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
decreases methylation increases expression |
ISO |
Azacitidine results in decreased methylation of PPARG promoter Azacitidine results in increased expression of PPARG mRNA |
CTD |
PMID:19589179 |
|
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Ppp2ca |
protein phosphatase 2 catalytic subunit alpha |
multiple interactions increases expression decreases methylation |
ISO |
Azacitidine promotes the reaction [CREB1 protein modified form binds to PPP2CA promoter] Azacitidine results in increased expression of PPP2CA mRNA Azacitidine results in decreased methylation of PPP2CA promoter |
CTD |
PMID:19155497 |
|
NCBI chr10:36,358,110...36,377,864
Ensembl chr10:36,358,101...36,377,862
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G |
Prdx4 |
peroxiredoxin 4 |
decreases expression |
EXP |
Azacitidine results in decreased expression of PRDX4 protein |
CTD |
PMID:17105402 |
|
NCBI chr X:40,026,762...40,044,066
Ensembl chr X:40,026,651...40,044,066
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G |
Prf1 |
perforin 1 |
multiple interactions |
ISO |
Azacitidine inhibits the reaction [IL2 protein results in increased secretion of PRF1 protein] |
CTD |
PMID:19394699 |
|
NCBI chr20:29,246,202...29,251,712
Ensembl chr20:29,246,202...29,251,701
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G |
Prl |
prolactin |
multiple interactions |
ISO |
[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate co-treated with Azacitidine] results in increased expression of PRL mRNA; [Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate co-treated with Azacitidine] results in increased expression of PRL protein |
CTD |
PMID:20823114 |
|
NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
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G |
Prom1 |
prominin 1 |
increases expression |
EXP |
Azacitidine results in increased expression of PROM1 mRNA |
CTD |
PMID:18037191 |
|
NCBI chr14:66,989,545...67,094,534
Ensembl chr14:66,990,160...67,094,527
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G |
Prss12 |
serine protease 12 |
decreases expression |
ISO |
Azacitidine results in decreased expression of PRSS12 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 2:211,624,134...211,684,126
Ensembl chr 2:211,624,134...211,684,126
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G |
Psen1 |
presenilin 1 |
decreases methylation multiple interactions |
ISO |
Azacitidine results in decreased methylation of PSEN1 promoter Betaine inhibits the reaction [Azacitidine results in decreased methylation of PSEN1 promoter] |
CTD |
PMID:19635394 |
|
NCBI chr 6:103,323,052...103,375,088
Ensembl chr 6:103,323,120...103,371,650
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G |
Pten |
phosphatase and tensin homolog |
multiple interactions |
ISO |
Azacitidine inhibits the reaction [TGFB1 protein results in decreased expression of PTEN mRNA]; Azacitidine inhibits the reaction [TGFB1 protein results in decreased expression of PTEN protein]; Azacitidine inhibits the reaction [TGFB1 protein results in increased methylation of PTEN promoter] |
CTD |
PMID:22841775 |
|
NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838
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G |
Pthlh |
parathyroid hormone-like hormone |
decreases expression |
ISO |
Azacitidine results in decreased expression of PTHLH mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 4:180,188,792...180,199,847
Ensembl chr 4:180,188,792...180,199,847
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G |
Ptpa |
protein phosphatase 2 phosphatase activator |
increases expression |
ISO |
Azacitidine results in increased expression of PTPA mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 3:13,689,742...13,720,287
Ensembl chr 3:13,689,741...13,722,549
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G |
Ptprc |
protein tyrosine phosphatase, receptor type, C |
increases expression |
ISO |
Azacitidine results in increased expression of PTPRC mRNA |
CTD |
PMID:19194470 |
|
NCBI chr13:49,596,193...49,708,283
Ensembl chr13:49,596,193...49,708,692
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G |
Ptpro |
protein tyrosine phosphatase, receptor type, O |
increases expression |
EXP |
Azacitidine results in increased expression of PTPRO mRNA |
CTD |
PMID:14508512 |
|
NCBI chr 4:170,164,071...170,374,790
Ensembl chr 4:170,164,431...170,374,771
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G |
Rab13 |
RAB13, member RAS oncogene family |
decreases methylation |
ISO |
Azacitidine results in decreased methylation of RAB13 promoter |
CTD |
PMID:19194470 |
|
NCBI chr 2:175,674,894...175,680,043
Ensembl chr 2:175,675,005...175,680,036
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G |
Rab1b |
RAB1B, member RAS oncogene family |
increases expression |
ISO |
Azacitidine results in increased expression of RAB1B mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 1:202,405,759...202,413,850
Ensembl chr 1:202,405,759...202,413,868 Ensembl chr X:202,405,759...202,413,868
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G |
Racgap1 |
Rac GTPase-activating protein 1 |
increases expression |
ISO |
Azacitidine results in increased expression of RACGAP1 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 7:130,750,936...130,780,891
Ensembl chr 7:130,750,936...130,780,831
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G |
Ranbp2 |
RAN binding protein 2 |
increases expression |
ISO |
Azacitidine results in increased expression of RANBP2 mRNA |
CTD |
PMID:19194470 |
|
NCBI chr20:26,442,156...26,493,481
Ensembl chr20:26,442,217...26,493,481
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G |
Rasa3 |
RAS p21 protein activator 3 |
increases expression |
ISO |
Azacitidine results in increased expression of RASA3 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr16:75,855,360...75,969,349
Ensembl chr16:75,855,265...75,970,804
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G |
Rcn1 |
reticulocalbin 1 |
decreases expression |
ISO |
Azacitidine results in decreased expression of RCN1 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 3:91,841,052...91,855,295
Ensembl chr 3:91,841,052...91,855,295
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
affects localization decreases expression |
ISO |
Azacitidine affects the localization of RELA protein 5-azacytidine decreases expression of RELA protein in lung cancer cells |
CTD RGD |
PMID:18443271 PMID:24356455 |
RGD:153344603 |
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Ret |
ret proto-oncogene |
decreases expression |
ISO |
Azacitidine results in decreased expression of RET mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 4:151,325,969...151,368,176
Ensembl chr 4:151,326,431...151,368,176
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G |
Rfc3 |
replication factor C subunit 3 |
multiple interactions |
ISO |
[Azacitidine co-treated with Thalidomide] affects the expression of RFC3 mRNA |
CTD |
PMID:18720364 |
|
NCBI chr12:1,000,987...1,011,778
Ensembl chr12:1,000,994...1,011,778
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G |
Rhob |
ras homolog family member B |
multiple interactions |
ISO |
[trichostatin A co-treated with Azacitidine] results in increased expression of RHOB protein; Azacitidine promotes the reaction [trichostatin A results in increased expression of RHOB mRNA] |
CTD |
PMID:18047684 |
|
NCBI chr 6:31,363,752...31,365,926
Ensembl chr 6:31,363,548...31,366,108
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G |
Rin1 |
Ras and Rab interactor 1 |
increases expression |
ISO |
Azacitidine results in increased expression of RIN1 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 1:202,355,729...202,362,731
Ensembl chr 1:202,355,890...202,362,729
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G |
Rpp21 |
ribonuclease P/MRP subunit p21 |
increases expression |
ISO |
Azacitidine results in increased expression of RPP21 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr20:2,018,170...2,020,100
Ensembl chr20:2,018,147...2,020,106
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G |
Rps6 |
ribosomal protein S6 |
decreases phosphorylation |
ISO |
Azacitidine results in decreased phosphorylation of RPS6 protein |
CTD |
PMID:21245298 |
|
NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602 Ensembl chr 5:101,371,136...101,374,602
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G |
Rpsa |
ribosomal protein SA |
decreases expression |
ISO |
Azacitidine results in decreased expression of RPSA mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 8:119,851,225...119,855,103
Ensembl chr 8:119,851,225...119,855,247
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|
G |
Rrm2 |
ribonucleotide reductase regulatory subunit M2 |
multiple interactions |
ISO |
[Azacitidine co-treated with Thalidomide] affects the expression of RRM2 mRNA |
CTD |
PMID:18720364 |
|
NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773
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|
G |
Rrm2b |
ribonucleotide reductase regulatory TP53 inducible subunit M2B |
increases expression |
ISO |
Azacitidine results in increased expression of RRM2B mRNA |
CTD |
PMID:19010910 |
|
NCBI chr 7:69,077,024...69,108,742
Ensembl chr 7:69,078,291...69,108,633
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G |
RT1-Da |
RT1 class II, locus Da |
multiple interactions |
ISO |
[Azacitidine promotes the reaction [IFNG protein results in increased expression of CIITA mRNA]] which results in increased expression of HLA-DRA protein |
CTD |
PMID:18829986 |
|
NCBI chr20:4,513,464...4,518,457
Ensembl chr20:4,512,911...4,518,455
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|
G |
Runx1 |
RUNX family transcription factor 1 |
multiple interactions |
ISO |
Azacitidine promotes the reaction [RUNX1 protein binds to KIR2DL2 promoter]; Azacitidine promotes the reaction [RUNX1 protein binds to KIR2DL4 promoter] |
CTD |
PMID:18945643 |
|
NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542
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G |
Runx3 |
RUNX family transcription factor 3 |
affects methylation |
ISO |
Azacitidine affects the methylation of RUNX3 gene |
CTD |
PMID:18058463 |
|
NCBI chr 5:147,360,587...147,419,161
Ensembl chr 5:147,360,994...147,419,156
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G |
S100a14 |
S100 calcium binding protein A14 |
decreases expression |
ISO |
Azacitidine results in decreased expression of S100A14 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 2:176,008,395...176,010,423
Ensembl chr 2:176,008,395...176,010,423
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G |
S100a9 |
S100 calcium binding protein A9 |
increases expression |
ISO |
Azacitidine results in increased expression of S100A9 mRNA |
CTD |
PMID:19194470 |
|
NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230
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G |
Sall4 |
spalt-like transcription factor 4 |
affects methylation |
ISO |
Azacitidine affects the methylation of SALL4 promoter |
CTD |
PMID:17546590 |
|
NCBI chr 3:157,474,067...157,491,055
Ensembl chr 3:157,474,642...157,490,822
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G |
Scamp4 |
secretory carrier membrane protein 4 |
increases expression |
ISO |
Azacitidine results in increased expression of SCAMP4 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 7:9,101,504...9,113,929
Ensembl chr 7:9,101,489...9,113,967
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G |
Sdcbp |
syndecan binding protein |
decreases expression |
ISO |
Azacitidine results in decreased expression of SDCBP mRNA |
CTD |
PMID:20823114 |
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NCBI chr 5:19,473,499...19,517,188
Ensembl chr 5:19,489,961...19,527,572
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G |
Sema3a |
semaphorin 3A |
increases expression |
ISO |
Azacitidine results in increased expression of SEMA3A mRNA |
CTD |
PMID:20823114 |
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NCBI chr 4:21,282,398...21,754,834
Ensembl chr 4:21,287,982...21,494,432
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G |
Sema6c |
semaphorin 6C |
increases expression |
ISO |
Azacitidine results in increased expression of SEMA6C mRNA |
CTD |
PMID:20823114 |
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NCBI chr 2:182,733,635...182,750,066
Ensembl chr 2:182,737,474...182,746,856
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G |
Senp3 |
SUMO specific peptidase 3 |
increases expression |
ISO |
Azacitidine results in increased expression of SENP3 mRNA |
CTD |
PMID:20823114 |
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NCBI chr10:54,390,698...54,399,590
Ensembl chr10:54,390,694...54,399,593
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G |
Six2 |
SIX homeobox 2 |
decreases expression multiple interactions |
ISO |
Azacitidine results in decreased expression of SIX2 mRNA Cisplatin affects the reaction [Azacitidine results in decreased expression of SIX2 mRNA] |
CTD |
PMID:36336710 |
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NCBI chr 6:8,974,859...8,981,345
Ensembl chr 6:8,967,157...8,981,193
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G |
Slbp |
stem-loop histone mRNA binding protein |
multiple interactions |
ISO |
Azacitidine inhibits the reaction [sodium arsenite results in decreased expression of SLBP mRNA] |
CTD |
PMID:25266719 |
|
NCBI chr14:77,071,441...77,081,911
Ensembl chr14:77,071,632...77,081,906
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G |
Slc28a1 |
solute carrier family 28 member 1 |
increases response to substance multiple interactions increases uptake |
ISO |
SLC28A1 protein results in increased susceptibility to Azacitidine [SLC28A1 protein results in increased uptake of Azacitidine] which results in decreased expression of DNMT1 protein; Sodium affects the reaction [SLC28A1 protein results in increased uptake of Azacitidine] |
CTD |
PMID:19139132 |
|
NCBI chr 1:135,079,375...135,122,791
Ensembl chr 1:135,081,385...135,122,464
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G |
Slc29a2 |
solute carrier family 29 member 2 |
decreases expression |
ISO |
Azacitidine results in decreased expression of SLC29A2 mRNA |
CTD |
PMID:19194470 |
|
NCBI chr 1:202,327,641...202,335,185
Ensembl chr 1:202,327,354...202,335,171
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G |
Slc5a5 |
solute carrier family 5 member 5 |
multiple interactions increases expression |
ISO |
[Azacitidine co-treated with Butyrates] affects the expression of SLC5A5 mRNA Azacitidine results in increased expression of SLC5A5 mRNA |
CTD |
PMID:16954431 PMID:17164311 |
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NCBI chr16:18,546,709...18,556,698
Ensembl chr16:18,546,709...18,556,697
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G |
Snu13 |
small nuclear ribonucleoprotein 13 |
increases expression |
ISO |
Azacitidine results in increased expression of SNU13 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 7:113,565,293...113,570,887
Ensembl chr 7:113,565,295...113,570,872 Ensembl chr 1:113,565,295...113,570,872
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G |
Socs3 |
suppressor of cytokine signaling 3 |
affects expression |
ISO |
Azacitidine affects the expression of SOCS3 protein |
CTD |
PMID:18443271 |
|
NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787
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G |
Sox13 |
SRY-box transcription factor 13 |
decreases expression |
ISO |
Azacitidine results in decreased expression of SOX13 mRNA |
CTD |
PMID:20823114 |
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NCBI chr13:44,831,097...44,875,522
Ensembl chr13:44,831,085...44,875,762
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G |
Sox2 |
SRY-box transcription factor 2 |
increases expression |
EXP |
Azacitidine results in increased expression of SOX2 mRNA |
CTD |
PMID:27415467 |
|
NCBI chr 2:117,536,929...117,539,340
Ensembl chr 2:117,536,929...117,539,338
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G |
Sox8 |
SRY-box transcription factor 8 |
decreases expression |
ISO |
Azacitidine results in decreased expression of SOX8 mRNA |
CTD |
PMID:18033690 |
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NCBI chr10:14,584,829...14,589,818
Ensembl chr10:14,584,829...14,589,818
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G |
Sox9 |
SRY-box transcription factor 9 |
affects expression |
ISO |
Azacitidine affects the expression of SOX9 mRNA |
CTD |
PMID:18033690 |
|
NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994
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G |
Sp1 |
Sp1 transcription factor |
multiple interactions decreases expression |
ISO |
Azacitidine promotes the reaction [SP1 protein binds to KIR2DL2 promoter]; Azacitidine promotes the reaction [SP1 protein binds to KIR2DL4 promoter] Azacitidine results in decreased expression of SP1 mRNA Azacitidine promotes the reaction [SP1 protein binds to AQP5 promoter] |
CTD |
PMID:17198683 PMID:18945643 PMID:20823114 |
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NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961
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G |
Sp7 |
Sp7 transcription factor |
increases expression |
ISO |
Azacitidine results in increased expression of SP7 mRNA |
CTD |
PMID:17085970 |
|
NCBI chr 7:133,484,609...133,494,788
Ensembl chr 7:133,484,609...133,494,847
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G |
Spag5 |
sperm associated antigen 5 |
multiple interactions |
ISO |
[Azacitidine co-treated with Thalidomide] affects the expression of SPAG5 mRNA |
CTD |
PMID:18720364 |
|
NCBI chr10:63,198,717...63,216,746
Ensembl chr10:63,198,768...63,216,745
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G |
Srpx |
sushi-repeat-containing protein, X-linked |
decreases expression |
ISO |
Azacitidine results in decreased expression of SRPX mRNA |
CTD |
PMID:19194470 |
|
NCBI chr X:12,676,984...12,751,296
Ensembl chr X:12,566,645...12,747,882
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G |
Srsf7 |
serine and arginine rich splicing factor 7 |
decreases expression |
ISO |
Azacitidine results in decreased expression of SRSF7 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 6:14,811,775...14,818,968
Ensembl chr 6:14,811,808...14,818,965
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G |
Ssx2ip |
SSX family member 2 interacting protein |
increases expression |
ISO |
Azacitidine results in increased expression of SSX2IP mRNA |
CTD |
PMID:20823114 |
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NCBI chr 2:235,298,012...235,330,750
Ensembl chr 2:235,298,088...235,330,745
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G |
St3gal6 |
ST3 beta-galactoside alpha-2,3-sialyltransferase 6 |
increases expression |
ISO |
Azacitidine results in increased expression of ST3GAL6 mRNA |
CTD |
PMID:19194470 |
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NCBI chr11:42,061,282...42,121,801
Ensembl chr11:42,077,621...42,121,776
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G |
St8sia2 |
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 |
decreases expression |
ISO |
Azacitidine results in decreased expression of ST8SIA2 mRNA |
CTD |
PMID:20823114 |
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NCBI chr 1:127,762,573...127,838,017
Ensembl chr 1:127,762,573...127,838,091
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G |
Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions |
ISO |
[Azacitidine affects the expression of IL6R protein] which affects the phosphorylation of STAT3 protein |
CTD |
PMID:18443271 |
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NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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G |
Stc2 |
stanniocalcin 2 |
decreases expression |
ISO |
Azacitidine results in decreased expression of STC2 mRNA |
CTD |
PMID:19194470 |
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NCBI chr10:16,251,046...16,260,815
Ensembl chr10:16,250,853...16,262,973
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G |
Stk38 |
serine/threonine kinase 38 |
decreases expression |
ISO |
Azacitidine results in decreased expression of STK38 mRNA |
CTD |
PMID:20823114 |
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NCBI chr20:7,034,245...7,067,803
Ensembl chr20:7,034,242...7,068,198
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G |
Sulf1 |
sulfatase 1 |
decreases expression |
ISO |
Azacitidine results in decreased expression of SULF1 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 5:6,362,894...6,526,174
Ensembl chr 5:6,362,911...6,525,584
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G |
Sult1c2a |
sulfotransferase family 1C member 2A |
increases expression |
ISO |
Azacitidine results in increased expression of SULT1C2 mRNA |
CTD |
PMID:19194470 |
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NCBI chr 9:6,873,697...6,904,736
Ensembl chr 9:6,874,249...6,904,734
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G |
Tat |
tyrosine aminotransferase |
increases expression |
ISO |
Azacitidine results in increased expression of TAT mRNA |
CTD |
PMID:27590069 |
|
NCBI chr19:37,947,153...37,957,717
Ensembl chr19:37,947,112...37,958,031
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G |
Tbc1d4 |
TBC1 domain family, member 4 |
decreases expression |
ISO |
Azacitidine results in decreased expression of TBC1D4 mRNA |
CTD |
PMID:19194470 |
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NCBI chr15:78,256,030...78,434,168
Ensembl chr15:78,257,121...78,434,265
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G |
Tcea1 |
transcription elongation factor A1 |
decreases expression |
ISO |
Azacitidine results in decreased expression of TCEA1 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 5:14,631,454...14,668,769
Ensembl chr 5:14,631,454...14,668,745 Ensembl chr15:14,631,454...14,668,745
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G |
Tecpr2 |
tectonin beta-propeller repeat containing 2 |
increases expression |
ISO |
Azacitidine results in increased expression of TECPR2 mRNA |
CTD |
PMID:19194470 |
|
NCBI chr 6:129,899,541...130,001,975
Ensembl chr 6:129,899,636...130,001,974
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G |
Tek |
TEK receptor tyrosine kinase |
increases expression |
EXP |
Azacitidine results in increased expression of TEK mRNA |
CTD |
PMID:18037191 |
|
NCBI chr 5:109,607,077...109,733,805
Ensembl chr 5:109,607,077...109,733,804
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G |
Tert |
telomerase reverse transcriptase |
decreases expression multiple interactions decreases methylation decreases activity |
ISO |
Azacitidine analog results in decreased expression of TERT mRNA; Azacitidine results in decreased expression of TERT mRNA E2F1 protein affects the reaction [Azacitidine results in decreased activity of TERT protein]; E2F1 protein affects the reaction [Azacitidine results in decreased expression of TERT mRNA]; MYC protein affects the reaction [Azacitidine results in decreased activity of TERT protein]; MYC protein affects the reaction [Azacitidine results in decreased expression of TERT mRNA] Azacitidine results in decreased methylation of TERT promoter |
CTD |
PMID:18045574 PMID:19451745 |
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NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561
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G |
Tfe3 |
transcription factor binding to IGHM enhancer 3 |
increases expression |
ISO |
Azacitidine results in increased expression of TFE3 mRNA |
CTD |
PMID:19194470 |
|
NCBI chr X:14,729,547...14,742,830
Ensembl chr X:14,729,550...14,742,571
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
ISO |
[Azacitidine co-treated with TGFB1 protein] results in increased expression of FOXP3 protein Azacitidine inhibits the reaction [TGFB1 protein results in decreased expression of PTEN mRNA]; Azacitidine inhibits the reaction [TGFB1 protein results in decreased expression of PTEN protein]; Azacitidine inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; Azacitidine inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; Azacitidine inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]; Azacitidine inhibits the reaction [TGFB1 protein results in increased methylation of PTEN promoter]; Azacitidine inhibits the reaction [TGFB1 protein results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:18493985 PMID:22841775 |
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NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Thumpd1 |
THUMP domain containing 1 |
increases expression |
ISO |
Azacitidine results in increased expression of THUMPD1 mRNA |
CTD |
PMID:19194470 |
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NCBI chr 1:174,078,875...174,084,915
Ensembl chr 1:174,078,878...174,084,937
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G |
Timp1 |
TIMP metallopeptidase inhibitor 1 |
increases expression |
ISO |
Azacitidine results in increased expression of TIMP1 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
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G |
Tjp1 |
tight junction protein 1 |
increases expression |
ISO |
Azacitidine results in increased expression of TJP1 mRNA |
CTD |
PMID:18661270 |
|
NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
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G |
Tmed3 |
transmembrane p24 trafficking protein 3 |
increases expression |
ISO |
Azacitidine results in increased expression of TMED3 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 8:90,241,516...90,249,429
Ensembl chr 8:90,241,516...90,249,346
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G |
Tmpo |
thymopoietin |
multiple interactions |
ISO |
[Azacitidine co-treated with Thalidomide] affects the expression of TMPO mRNA |
CTD |
PMID:18720364 |
|
NCBI chr 7:25,642,752...25,667,756
Ensembl chr 7:25,586,725...25,667,727
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G |
Tnc |
tenascin C |
decreases expression |
ISO |
Azacitidine results in decreased expression of TNC mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624
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G |
Tnf |
tumor necrosis factor |
increases expression increases response to substance |
EXP ISO |
Azacitidine results in increased expression of TNF mRNA Azacitidine results in increased susceptibility to TNF protein |
CTD |
PMID:17156202 PMID:18829727 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tnfsf10 |
TNF superfamily member 10 |
increases response to substance |
ISO |
Azacitidine results in increased susceptibility to TNFSF10 protein |
CTD |
PMID:18829727 |
|
NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
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G |
Tnni3 |
troponin I3, cardiac type |
increases expression |
EXP |
Azacitidine results in increased expression of TNNI3 protein |
CTD |
PMID:17105402 |
|
NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580
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G |
Tnnt2 |
troponin T2, cardiac type |
increases expression |
EXP |
Azacitidine results in increased expression of TNNT2 protein |
CTD |
PMID:22496879 |
|
NCBI chr13:47,267,325...47,285,390
Ensembl chr13:47,267,204...47,285,388
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G |
Top2a |
DNA topoisomerase II alpha |
multiple interactions |
ISO |
[Azacitidine co-treated with Thalidomide] affects the expression of TOP2A mRNA; [Curcumin co-treated with Azacitidine] results in decreased expression of TOP2A mRNA |
CTD |
PMID:18348204 PMID:18720364 |
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NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874
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G |
Tp53 |
tumor protein p53 |
affects activity |
ISO |
Azacitidine affects the activity of TP53 protein |
CTD |
PMID:35435491 |
|
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Tp73 |
tumor protein p73 |
multiple interactions |
ISO |
TP73 protein promotes the reaction [Azacitidine results in increased expression of HMGA2 mRNA]; TP73 protein promotes the reaction [Azacitidine results in increased expression of KLF6 mRNA]; TP73 protein promotes the reaction [Azacitidine results in increased expression of NIBAN1 mRNA] |
CTD |
PMID:21245298 |
|
NCBI chr 5:164,621,377...164,703,958
Ensembl chr 5:164,621,377...164,681,128
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G |
Tpd52 |
tumor protein D52 |
increases expression |
EXP |
Azacitidine results in increased expression of TPD52 mRNA |
CTD |
PMID:27415467 |
|
NCBI chr 2:92,735,365...92,816,079
Ensembl chr 2:92,735,620...92,816,622
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G |
Tpm2 |
tropomyosin 2 |
increases expression |
ISO |
Azacitidine results in increased expression of TPM2 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr 5:57,770,919...57,780,278
Ensembl chr 5:57,770,864...57,779,992
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G |
Tpo |
thyroid peroxidase |
increases expression |
ISO |
Azacitidine results in increased expression of TPO mRNA |
CTD |
PMID:17679169 |
|
NCBI chr 6:46,698,402...46,768,199
Ensembl chr 6:46,698,414...46,768,199
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G |
Tpsg1 |
tryptase gamma 1 |
decreases expression |
ISO |
Azacitidine results in decreased expression of TPSG1 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr10:14,386,352...14,390,258
Ensembl chr10:14,386,352...14,390,258
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G |
Trh |
thyrotropin releasing hormone |
decreases expression |
ISO |
Azacitidine results in decreased expression of TRH mRNA |
CTD |
PMID:19194470 |
|
NCBI chr 4:124,742,111...124,777,094
Ensembl chr 4:124,742,111...124,744,637
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G |
Trib1 |
tribbles pseudokinase 1 |
decreases expression |
ISO |
Azacitidine results in decreased expression of TRIB1 mRNA |
CTD |
PMID:19194470 |
|
NCBI chr 7:91,206,579...91,213,126
Ensembl chr 7:91,206,579...91,214,731
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G |
Trim8 |
tripartite motif-containing 8 |
increases expression |
ISO |
Azacitidine results in increased expression of TRIM8 mRNA |
CTD |
PMID:19194470 |
|
NCBI chr 1:245,369,632...245,384,513
Ensembl chr 1:245,369,632...245,384,513
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G |
Tsc1 |
TSC complex subunit 1 |
multiple interactions |
ISO |
[Azacitidine affects the methylation of TSC1 promoter] which affects the expression of TSC1 mRNA |
CTD |
PMID:18538015 |
|
NCBI chr 3:11,969,547...12,018,591
Ensembl chr 3:11,979,729...12,015,674
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G |
Tsc2 |
TSC complex subunit 2 |
decreases methylation multiple interactions increases expression |
ISO |
Azacitidine results in decreased methylation of TSC2 promoter [Azacitidine affects the methylation of TSC2 promoter] which affects the expression of TSC2 mRNA Azacitidine results in increased expression of TSC2 mRNA |
CTD |
PMID:18538015 PMID:19250671 |
|
NCBI chr10:13,621,135...13,655,773
Ensembl chr10:13,621,136...13,655,951
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G |
Tshr |
thyroid stimulating hormone receptor |
increases expression |
ISO |
Azacitidine results in increased expression of TSHR mRNA |
CTD |
PMID:17679169 |
|
NCBI chr 6:110,341,585...110,475,297
Ensembl chr 6:110,341,581...110,474,538
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G |
Tspan32 |
tetraspanin 32 |
decreases expression |
ISO |
Azacitidine results in decreased expression of TSPAN32 mRNA |
CTD |
PMID:19194470 |
|
NCBI chr 1:198,190,128...198,204,447
Ensembl chr 1:198,190,164...198,204,445
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G |
Ttk |
Ttk protein kinase |
multiple interactions |
ISO |
[Azacitidine co-treated with Thalidomide] affects the expression of TTK mRNA |
CTD |
PMID:18720364 |
|
NCBI chr 8:84,754,329...84,792,653
Ensembl chr 8:84,754,315...84,792,651
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G |
Ube2c |
ubiquitin-conjugating enzyme E2C |
multiple interactions |
ISO |
[Azacitidine co-treated with Thalidomide] affects the expression of UBE2C mRNA |
CTD |
PMID:18720364 |
|
NCBI chr 3:153,506,636...153,509,036
Ensembl chr 3:153,506,636...153,513,339
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G |
Uhmk1 |
U2AF homology motif kinase 1 |
increases expression |
ISO |
Azacitidine results in increased expression of UHMK1 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr13:82,396,646...82,416,292
Ensembl chr13:82,401,187...82,416,292
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G |
Ush2a |
usherin |
increases expression |
ISO |
Azacitidine results in increased expression of USH2A mRNA |
CTD |
PMID:20823114 |
|
NCBI chr13:99,837,445...100,503,935
Ensembl chr13:99,837,445...100,503,922
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G |
Ushbp1 |
USH1 protein network component harmonin binding protein 1 |
decreases expression |
ISO |
Azacitidine results in decreased expression of USHBP1 mRNA |
CTD |
PMID:20823114 |
|
NCBI chr16:18,057,321...18,067,933
Ensembl chr16:18,057,326...18,067,877
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G |
Vim |
vimentin |
decreases expression increases expression multiple interactions |
EXP ISO |
Azacitidine results in decreased expression of VIM protein Azacitidine results in increased expression of VIM mRNA; Azacitidine results in increased expression of VIM protein [Azacitidine co-treated with Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of VIM protein |
CTD |
PMID:17105402 PMID:20823114 |
|
NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
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G |
Wdr47 |
WD repeat domain 47 |
decreases expression |
ISO |
Azacitidine results in decreased expression of WDR47 mRNA |
CTD |
PMID:19194470 |
|
NCBI chr 2:196,226,757...196,287,739
Ensembl chr 2:196,205,238...196,287,739
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G |
Wnt10b |
Wnt family member 10B |
increases expression |
EXP |
Azacitidine results in increased expression of WNT10B mRNA |
CTD |
PMID:27415467 |
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NCBI chr 7:129,922,088...129,927,892
Ensembl chr 7:129,922,088...129,927,892
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G |
Wnt5a |
Wnt family member 5A |
increases expression |
ISO |
Azacitidine results in increased expression of WNT5A mRNA |
CTD |
PMID:20823114 |
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NCBI chr16:3,697,032...3,718,230
Ensembl chr16:3,697,032...3,718,234
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G |
Wwtr1 |
WW domain containing transcription regulator 1 |
increases expression |
ISO |
Azacitidine results in increased expression of WWTR1 mRNA |
CTD |
PMID:20823114 |
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NCBI chr 2:141,651,159...141,766,919
Ensembl chr 2:141,648,108...141,766,968
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G |
Xaf1 |
XIAP associated factor 1 |
decreases expression decreases methylation increases expression |
ISO |
Azacitidine results in decreased expression of XAF1 mRNA alternative form Azacitidine results in decreased methylation of XAF1 promoter Azacitidine results in increased expression of XAF1 mRNA; Azacitidine results in increased expression of XAF1 protein |
CTD |
PMID:19077051 PMID:19549372 |
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NCBI chr10:56,917,378...56,929,791
Ensembl chr10:56,917,121...56,929,770
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G |
Zfp189 |
zinc finger protein 189 |
decreases expression |
ISO |
Azacitidine results in decreased expression of ZNF189 mRNA |
CTD |
PMID:20823114 |
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NCBI chr 5:63,872,596...63,884,348
Ensembl chr 5:63,872,738...63,884,121
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G |
Zfp64 |
zinc finger protein 64 |
affects methylation |
ISO |
Azacitidine affects the methylation of ZFP64 promoter |
CTD |
PMID:17546590 |
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NCBI chr 3:157,666,819...157,695,774
Ensembl chr 3:157,633,211...157,695,809
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G |
Zp3 |
zona pellucida glycoprotein 3 |
increases expression |
ISO |
Azacitidine results in increased expression of ZP3 mRNA |
CTD |
PMID:20823114 |
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NCBI chr12:20,690,547...20,697,513
Ensembl chr12:20,690,547...20,697,513
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G |
Hsd17b2 |
hydroxysteroid (17-beta) dehydrogenase 2 |
affects binding |
ISO |
acetoacetyl CoA binds to HSD17B2 protein |
CTD |
PMID:25526675 |
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NCBI chr19:45,753,576...45,825,203
Ensembl chr19:45,753,574...45,825,202
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G |
Acly |
ATP citrate lyase |
increases abundance affects abundance |
ISO |
ACLY protein results in increased abundance of Acetyl Coenzyme A ACLY protein affects the abundance of Acetyl Coenzyme A |
CTD |
PMID:28077572 PMID:36933457 |
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NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320
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G |
App |
amyloid beta precursor protein |
affects localization increases secretion multiple interactions |
ISO |
APP protein affects the localization of Acetyl Coenzyme A Acetyl Coenzyme A results in increased secretion of APP protein modified form Acetyl Coenzyme A inhibits the reaction [Hydrogen Peroxide results in decreased secretion of APP protein modified form] IL1B protein affects the reaction [APP protein affects the localization of Acetyl Coenzyme A] |
CTD |
PMID:16122837 PMID:22906069 |
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NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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G |
Crat |
carnitine O-acetyltransferase |
decreases activity |
EXP |
Acetyl Coenzyme A deficiency results in decreased activity of CRAT protein |
CTD |
PMID:8075222 |
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NCBI chr 3:13,675,684...13,689,282
Ensembl chr 3:13,675,684...13,689,255
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G |
Ercc6 |
ERCC excision repair 6, chromatin remodeling factor |
decreases abundance multiple interactions |
ISO |
ERCC6 gene mutant form results in decreased abundance of Acetyl Coenzyme A 3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in decreased abundance of Acetyl Coenzyme A]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [ERCC6 gene mutant form results in decreased abundance of Acetyl Coenzyme A] |
CTD |
PMID:25440059 |
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NCBI chr16:7,764,983...7,835,587
Ensembl chr16:7,765,013...7,835,587
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G |
G6pc1 |
glucose-6-phosphatase catalytic subunit 1 |
multiple interactions |
ISO |
[Fluoxetine results in decreased expression of G6PC1 protein] which results in increased abundance of Acetyl Coenzyme A |
CTD |
PMID:33179799 |
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NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
IL1B protein affects the reaction [APP protein affects the localization of Acetyl Coenzyme A] |
CTD |
PMID:16122837 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Kat2b |
lysine acetyltransferase 2B |
affects binding |
ISO |
Acetyl Coenzyme A binds to KAT2B protein |
CTD |
PMID:28077572 |
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NCBI chr 9:6,562,525...6,667,064
Ensembl chr 9:6,562,288...6,667,064
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G |
Metrnl |
meteorin-like, glial cell differentiation regulator |
multiple interactions |
ISO |
METRNL protein inhibits the reaction [Dietary Fats results in decreased abundance of Acetyl Coenzyme A] |
CTD |
PMID:30213948 |
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NCBI chr10:106,963,880...106,977,875
Ensembl chr10:106,963,880...106,977,869
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G |
Nat1 |
N-acetyltransferase 1 |
multiple interactions affects binding |
ISO |
[NQO1 protein co-treated with NADP co-treated with Acetyl Coenzyme A co-treated with NAT1 protein] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone; Acetyl Coenzyme A inhibits the reaction [Cyanamide results in decreased activity of NAT1 protein]; Acetyl Coenzyme A inhibits the reaction [Iodoacetamide results in decreased activity of NAT1 protein] Acetyl Coenzyme A binds to NAT1 protein |
CTD |
PMID:20545351 PMID:22835378 |
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NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520
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G |
Nat2 |
N-acetyltransferase 2 |
multiple interactions |
ISO |
[NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[NQO1 protein co-treated with NADP] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone]; [NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[SULT1A2 protein co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone] |
CTD |
PMID:20545351 |
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NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
multiple interactions |
ISO |
[NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[NQO1 protein co-treated with NADP] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone]; [NQO1 protein co-treated with NADP co-treated with Acetyl Coenzyme A co-treated with NAT1 protein] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone |
CTD |
PMID:20545351 |
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NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Echs1 |
enoyl-CoA hydratase, short chain 1 |
increases abundance |
ISO |
ECHS1 gene mutant form results in increased abundance of acryloyl-coenzyme A |
CTD |
PMID:25125611 |
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NCBI chr 1:194,895,036...194,903,863
Ensembl chr 1:194,895,036...194,903,884
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G |
Hibch |
3-hydroxyisobutyryl-CoA hydrolase |
increases abundance |
ISO |
HIBCH gene mutant form results in increased abundance of acryloyl-coenzyme A |
CTD |
PMID:25125611 |
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NCBI chr 9:48,590,097...48,669,896
Ensembl chr 9:48,590,099...48,669,824
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G |
Ada |
adenosine deaminase |
decreases metabolic processing increases metabolic processing |
ISO |
ADA alternative form results in decreased metabolism of Adenosine ADA protein results in increased metabolism of Adenosine |
CTD |
PMID:16221767 |
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NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088
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G |
Adora1 |
adenosine A1 receptor |
multiple interactions affects binding |
ISO EXP |
Adenosine analog binds to and affects the activity of ADORA1 protein; Adenosine analog binds to and results in decreased activity of ADORA1 protein; PD 81723 affects the reaction [Adenosine analog binds to and affects the activity of ADORA1 protein]; VUF 5455 affects the reaction [Adenosine analog binds to and affects the activity of ADORA1 protein] [lead acetate results in increased expression of ADORA1 protein] which results in increased abundance of Adenosine; Adenosine analog binds to and results in increased activity of ADORA1 protein Adenosine binds to ADORA1 protein |
CTD |
PMID:10649980 PMID:11520205 PMID:18404447 PMID:20571079 PMID:20932874 |
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NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801
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G |
Adora2a |
adenosine A2a receptor |
multiple interactions affects binding |
ISO |
Adenosine analog binds to and results in decreased activity of ADORA2A protein; Adenosine promotes the reaction [Lipopolysaccharides results in increased expression of ADORA2A mRNA] Adenosine binds to ADORA2A protein |
CTD |
PMID:18404447 PMID:20067761 |
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NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386
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G |
Adora2b |
adenosine A2B receptor |
affects response to substance |
ISO |
ADORA2B protein affects the susceptibility to Adenosine |
CTD |
PMID:16920807 |
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NCBI chr10:46,940,394...46,956,772
Ensembl chr10:46,940,384...46,956,772
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G |
Adora3 |
adenosine A3 receptor |
multiple interactions increases expression affects binding |
ISO |
Adenosine analog binds to and affects the activity of ADORA3 protein; Adenosine analog binds to and results in decreased activity of ADORA3 protein; Adenosine analog binds to and results in increased activity of ADORA3 protein; PD 81723 affects the reaction [Adenosine analog binds to and affects the activity of ADORA3 protein]; VUF 5455 affects the reaction [Adenosine analog binds to and affects the activity of ADORA3 protein] Adenosine results in increased expression of ADORA3 mRNA Adenosine binds to ADORA3 protein |
CTD |
PMID:11520205 PMID:18404447 PMID:20067761 PMID:20571079 |
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NCBI chr 2:193,352,759...193,392,946
Ensembl chr 2:193,388,713...193,392,357
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G |
Alpi |
alkaline phosphatase, intestinal |
multiple interactions |
ISO |
Adenosine inhibits the reaction [Methotrexate results in increased activity of ALPI protein] |
CTD |
PMID:16598758 |
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NCBI chr 9:87,773,411...87,776,877
Ensembl chr 9:87,773,411...87,776,877
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G |
Ampd2 |
adenosine monophosphate deaminase 2 |
multiple interactions |
ISO |
[tofacitinib results in decreased expression of AMPD2 protein] which affects the abundance of Adenosine |
CTD |
PMID:25496463 |
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NCBI chr 2:195,707,609...195,720,454
Ensembl chr 2:195,707,610...195,720,271
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases localization multiple interactions |
ISO |
Adenosine results in increased localization of BAX protein Thymidine inhibits the reaction [Adenosine results in increased localization of BAX protein] |
CTD |
PMID:11570579 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2l1 |
Bcl2-like 1 |
decreases expression multiple interactions |
ISO |
Adenosine results in decreased expression of BCL2L1 mRNA; Adenosine results in decreased expression of BCL2L1 protein Dipyridamole inhibits the reaction [Adenosine results in decreased expression of BCL2L1 mRNA]; Dipyridamole inhibits the reaction [Adenosine results in decreased expression of BCL2L1 protein] |
CTD |
PMID:20063052 |
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NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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G |
Birc2 |
baculoviral IAP repeat-containing 2 |
decreases expression |
ISO |
Adenosine results in decreased expression of BIRC2 mRNA; Adenosine results in decreased expression of BIRC2 protein |
CTD |
PMID:20063052 |
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NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
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G |
Birc3 |
baculoviral IAP repeat-containing 3 |
decreases expression |
ISO |
Adenosine results in decreased expression of BIRC3 mRNA |
CTD |
PMID:20063052 |
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NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
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G |
Bmp2 |
bone morphogenetic protein 2 |
increases expression |
ISO |
Adenosine results in increased expression of BMP2 mRNA |
CTD |
PMID:34070360 |
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NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
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G |
Bmp4 |
bone morphogenetic protein 4 |
increases expression multiple interactions |
ISO |
Adenosine results in increased expression of BMP4 mRNA N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Adenosine results in increased expression of BMP4 mRNA]; PSB603 inhibits the reaction [Adenosine results in increased expression of BMP4 mRNA]; ZM 241385 inhibits the reaction [Adenosine results in increased expression of BMP4 mRNA] |
CTD |
PMID:34070360 |
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NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306
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G |
Bmpr1a |
bone morphogenetic protein receptor type 1A |
increases expression |
ISO |
Adenosine results in increased expression of BMPR1A mRNA |
CTD |
PMID:34070360 |
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NCBI chr16:9,736,390...9,829,825
Ensembl chr16:9,736,630...9,780,616
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G |
Casp3 |
caspase 3 |
multiple interactions increases activity |
ISO EXP |
Dipyridamole inhibits the reaction [Adenosine results in increased activity of CASP3 protein]; Thymidine inhibits the reaction [Adenosine results in increased activity of CASP3 protein] |
CTD |
PMID:11570579 PMID:16469385 PMID:17303086 PMID:20063052 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp8 |
caspase 8 |
increases activity multiple interactions |
ISO EXP |
Adenosine results in increased activity of CASP8 protein Dipyridamole inhibits the reaction [Adenosine results in increased activity of CASP8 protein] |
CTD |
PMID:16469385 PMID:17303086 |
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NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Casp9 |
caspase 9 |
increases activity multiple interactions |
ISO EXP |
Adenosine results in increased activity of CASP9 protein Thymidine inhibits the reaction [Adenosine results in increased activity of CASP9 protein] |
CTD |
PMID:11570579 PMID:16469385 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Ccnd1 |
cyclin D1 |
increases expression |
ISO |
Adenosine results in increased expression of CCND1 mRNA |
CTD |
PMID:34070360 |
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NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Cd14 |
CD14 molecule |
increases expression |
ISO |
Adenosine results in increased expression of CD14 mRNA |
CTD |
PMID:21538184 |
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NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
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G |
Cflar |
CASP8 and FADD-like apoptosis regulator |
decreases expression multiple interactions |
ISO |
Adenosine results in decreased expression of CFLAR mRNA; Adenosine results in decreased expression of CFLAR mRNA alternative form; Adenosine results in decreased expression of CFLAR protein Dipyridamole inhibits the reaction [Adenosine results in decreased expression of CFLAR mRNA alternative form]; Dipyridamole inhibits the reaction [Adenosine results in decreased expression of CFLAR mRNA]; Dipyridamole inhibits the reaction [Adenosine results in decreased expression of CFLAR protein] |
CTD |
PMID:17303086 |
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NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034
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G |
Cftr |
CF transmembrane conductance regulator |
increases activity multiple interactions |
ISO |
Adenosine results in increased activity of CFTR protein [Isoproterenol co-treated with Adenosine] results in increased activity of CFTR protein |
CTD |
PMID:15039139 |
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NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
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G |
Creb1 |
cAMP responsive element binding protein 1 |
increases expression multiple interactions |
ISO |
Adenosine results in increased expression of CREB1 mRNA N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Adenosine results in increased expression of CREB1 mRNA]; PSB603 inhibits the reaction [Adenosine results in increased expression of CREB1 mRNA]; ZM 241385 inhibits the reaction [Adenosine results in increased expression of CREB1 mRNA] |
CTD |
PMID:34070360 |
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NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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G |
Ctnnb1 |
catenin beta 1 |
increases expression |
ISO |
Adenosine results in increased expression of CTNNB1 mRNA |
CTD |
PMID:34070360 |
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NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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G |
Diablo |
diablo, IAP-binding mitochondrial protein |
increases expression multiple interactions |
ISO |
Adenosine results in increased expression of DIABLO mRNA; Adenosine results in increased expression of DIABLO protein Dipyridamole inhibits the reaction [Adenosine results in increased expression of DIABLO mRNA]; Dipyridamole inhibits the reaction [Adenosine results in increased expression of DIABLO protein] |
CTD |
PMID:20063052 |
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NCBI chr12:33,055,784...33,070,401
Ensembl chr12:33,055,263...33,070,387
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G |
Dkk1 |
dickkopf WNT signaling pathway inhibitor 1 |
increases expression |
ISO |
Adenosine results in increased expression of DKK1 mRNA |
CTD |
PMID:34070360 |
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NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202
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G |
Dpp4 |
dipeptidylpeptidase 4 |
decreases expression multiple interactions |
ISO |
Adenosine results in decreased expression of DPP4 mRNA; Adenosine results in decreased expression of DPP4 protein [Adenosine results in decreased phosphorylation of MAPK1 protein] which results in decreased expression of DPP4 mRNA; [Adenosine results in decreased phosphorylation of MAPK1 protein] which results in decreased expression of DPP4 protein; [Adenosine results in decreased phosphorylation of MAPK3 protein] which results in decreased expression of DPP4 mRNA; [Adenosine results in decreased phosphorylation of MAPK3 protein] which results in decreased expression of DPP4 protein |
CTD |
PMID:16611738 |
|
NCBI chr 3:46,962,233...47,043,870
Ensembl chr 3:46,962,243...47,043,901
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G |
Egf |
epidermal growth factor |
increases expression multiple interactions |
ISO |
Adenosine results in increased expression of EGF mRNA Adenosine results in increased expression of and results in increased secretion of EGF protein |
CTD |
PMID:34070360 |
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NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064
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G |
Esr1 |
estrogen receptor 1 |
increases expression |
ISO |
Adenosine results in increased expression of ESR1 protein |
CTD |
PMID:29360751 |
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NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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G |
Esr2 |
estrogen receptor 2 |
increases expression |
ISO |
Adenosine results in increased expression of ESR2 protein |
CTD |
PMID:29360751 |
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NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
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G |
Fadd |
Fas associated via death domain |
decreases expression multiple interactions |
ISO |
Adenosine results in decreased expression of FADD mRNA Dipyridamole inhibits the reaction [Adenosine results in decreased expression of FADD mRNA] |
CTD |
PMID:17303086 |
|
NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
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G |
Faslg |
Fas ligand |
increases expression multiple interactions |
ISO |
Adenosine results in increased expression of FASLG protein [Adenosine co-treated with Coformycin] results in decreased expression of FASL mRNA |
CTD |
PMID:11992407 PMID:16419169 |
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NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
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G |
Fgf6 |
fibroblast growth factor 6 |
multiple interactions |
ISO |
Adenosine results in increased expression of and results in increased secretion of FGF6 protein |
CTD |
PMID:34070360 |
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NCBI chr 4:159,854,913...159,863,447
Ensembl chr 4:159,854,913...159,863,447
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G |
Fshb |
follicle stimulating hormone subunit beta |
increases expression |
ISO |
Adenosine results in increased expression of FSHB protein |
CTD |
PMID:29360751 |
|
NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
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G |
Fzd3 |
frizzled class receptor 3 |
increases expression |
ISO |
Adenosine results in increased expression of FZD3 mRNA |
CTD |
PMID:34070360 |
|
NCBI chr15:39,421,366...39,488,369
Ensembl chr15:39,421,355...39,488,369
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G |
Fzd5 |
frizzled class receptor 5 |
increases expression |
ISO |
Adenosine results in increased expression of FZD5 mRNA |
CTD |
PMID:34070360 |
|
NCBI chr 9:66,113,096...66,120,276
Ensembl chr 9:66,113,112...66,121,457
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G |
Gdnf |
glial cell derived neurotrophic factor |
increases secretion |
ISO |
Adenosine results in increased secretion of GDNF protein |
CTD |
PMID:34070360 |
|
NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
increases phosphorylation increases expression |
ISO |
Adenosine results in increased phosphorylation of GSK3B protein Adenosine results in increased expression of GSK3B mRNA |
CTD |
PMID:34070360 |
|
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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G |
Gzmb |
granzyme B |
multiple interactions |
ISO |
[Adenosine co-treated with Coformycin] results in decreased expression of GZMB mRNA |
CTD |
PMID:11992407 |
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NCBI chr15:30,343,352...30,346,814
Ensembl chr15:30,173,603...30,346,814
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G |
H2ax |
H2A.X variant histone |
multiple interactions |
ISO |
Adenosine promotes the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form] |
CTD |
PMID:32941855 |
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NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
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G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
increases expression |
ISO |
Adenosine results in increased expression of HIF1A mRNA |
CTD |
PMID:20067761 |
|
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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G |
Idh2 |
isocitrate dehydrogenase (NADP(+)) 2 |
increases abundance multiple interactions |
ISO |
IDH2 protein mutant form results in increased abundance of Adenosine Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Adenosine] |
CTD |
PMID:27469509 |
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NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025
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G |
Ifng |
interferon gamma |
multiple interactions |
ISO |
[Adenosine co-treated with Coformycin] results in decreased expression of IFNG protein |
CTD |
PMID:11992407 |
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NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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G |
Igf1 |
insulin-like growth factor 1 |
affects expression multiple interactions |
ISO |
Adenosine affects the expression of IGF1 mRNA Adenosine results in increased expression of and results in increased secretion of IGF1 protein |
CTD |
PMID:34070360 |
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NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
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G |
Igf2 |
insulin-like growth factor 2 |
multiple interactions |
ISO |
Adenosine results in increased expression of and results in increased secretion of IGF2 protein |
CTD |
PMID:34070360 |
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NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018
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G |
Il10 |
interleukin 10 |
multiple interactions increases expression |
ISO |
Adenosine promotes the reaction [Lipopolysaccharides results in increased secretion of IL10 protein] Adenosine results in increased expression of IL10 mRNA; Adenosine results in increased expression of IL10 protein |
CTD |
PMID:11023991 |
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NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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G |
Il12b |
interleukin 12B |
decreases expression multiple interactions |
ISO |
Adenosine results in decreased expression of IL12B protein Adenosine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein] |
CTD |
PMID:11023991 |
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NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
EXP |
Adenosine inhibits the reaction [IL1B protein results in increased abundance of Nitric Oxide]; Adenosine inhibits the reaction [IL1B protein results in increased expression of IL1R1]; Adenosine inhibits the reaction [IL1B protein results in increased expression of NOS2 mRNA]; Adenosine inhibits the reaction [IL1B protein results in increased expression of NOS2 protein] |
CTD |
PMID:24878381 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il1r1 |
interleukin 1 receptor type 1 |
multiple interactions |
EXP |
Adenosine inhibits the reaction [IL1B protein results in increased expression of IL1R1] |
CTD |
PMID:24878381 |
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NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937
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G |
Il2 |
interleukin 2 |
multiple interactions |
ISO |
[Adenosine co-treated with Coformycin] results in decreased expression of IL2 protein |
CTD |
PMID:11992407 |
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NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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G |
Lef1 |
lymphoid enhancer binding factor 1 |
increases expression |
ISO |
Adenosine results in increased expression of LEF1 mRNA |
CTD |
PMID:34070360 |
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NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794
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G |
Ly96 |
lymphocyte antigen 96 |
increases expression |
ISO |
Adenosine results in increased expression of LY96 mRNA |
CTD |
PMID:21538184 |
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NCBI chr 5:2,582,233...2,612,357
Ensembl chr 5:2,582,254...2,612,386
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G |
Map2k1 |
mitogen activated protein kinase kinase 1 |
increases phosphorylation |
ISO |
Adenosine results in increased phosphorylation of MAP2K1 protein |
CTD |
PMID:34070360 |
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NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
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G |
Map2k2 |
mitogen activated protein kinase kinase 2 |
increases phosphorylation |
ISO |
Adenosine results in increased phosphorylation of MAP2K2 protein |
CTD |
PMID:34070360 |
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NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions decreases phosphorylation |
ISO |
[Adenosine results in decreased phosphorylation of MAPK1 protein] which results in decreased expression of DPP4 mRNA; [Adenosine results in decreased phosphorylation of MAPK1 protein] which results in decreased expression of DPP4 protein |
CTD |
PMID:16611738 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
decreases phosphorylation multiple interactions |
ISO |
Adenosine results in decreased phosphorylation of MAPK3 protein [Adenosine results in decreased phosphorylation of MAPK3 protein] which results in decreased expression of DPP4 mRNA; [Adenosine results in decreased phosphorylation of MAPK3 protein] which results in decreased expression of DPP4 protein |
CTD |
PMID:16611738 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mki67 |
marker of proliferation Ki-67 |
affects expression |
ISO |
Adenosine affects the expression of MKI67 mRNA |
CTD |
PMID:34070360 |
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NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
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G |
Mtor |
mechanistic target of rapamycin kinase |
increases phosphorylation |
ISO |
Adenosine results in increased phosphorylation of MTOR protein |
CTD |
PMID:34070360 |
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NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
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G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
decreases expression increases expression multiple interactions |
ISO |
Adenosine results in decreased expression of MYC protein Adenosine results in increased expression of MYC mRNA Thymidine inhibits the reaction [Adenosine results in decreased expression of MYC protein]; Uridine inhibits the reaction [Adenosine results in decreased expression of MYC protein] |
CTD |
PMID:9808420 PMID:34070360 |
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NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
[Adenosine co-treated with Homocysteine] affects the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; [Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]; [Adenosine co-treated with Homocysteine] results in decreased expression of NFKBIA mRNA |
CTD |
PMID:24224954 |
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NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Nos2 |
nitric oxide synthase 2 |
decreases stability multiple interactions |
EXP |
Adenosine results in decreased stability of NOS2 mRNA Adenosine inhibits the reaction [IL1B protein results in increased expression of NOS2 mRNA]; Adenosine inhibits the reaction [IL1B protein results in increased expression of NOS2 protein] |
CTD |
PMID:24878381 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nt5e |
5' nucleotidase, ecto |
multiple interactions |
ISO |
[alpha,beta-methyleneadenosine 5'-diphosphate results in decreased activity of NT5E protein] inhibits the reaction [Oxygen deficiency results in increased abundance of Adenosine] |
CTD |
PMID:23437309 |
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NCBI chr 8:89,271,046...89,314,918
Ensembl chr 8:89,270,696...89,314,881
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G |
Pgf |
placental growth factor |
increases secretion |
ISO |
Adenosine results in increased secretion of PGF protein |
CTD |
PMID:34070360 |
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NCBI chr 6:104,816,102...104,826,685
Ensembl chr 6:104,816,104...104,826,685
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G |
Ppargc1a |
PPARG coactivator 1 alpha |
increases expression |
ISO |
Adenosine results in increased expression of PPARGC1A mRNA |
CTD |
PMID:23056435 |
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NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
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G |
Prf1 |
perforin 1 |
multiple interactions |
ISO |
[Adenosine co-treated with Coformycin] results in decreased expression of PRF1 mRNA |
CTD |
PMID:11992407 |
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NCBI chr20:29,246,202...29,251,712
Ensembl chr20:29,246,202...29,251,701
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G |
Ptgdr |
prostaglandin D2 receptor |
multiple interactions |
ISO |
[Prostaglandin D2 results in increased activity of PTGDR protein] which results in increased metabolism of Adenosine; [Prostaglandin D2 results in increased activity of PTGDR protein] which results in increased secretion of Adenosine |
CTD |
PMID:11562489 |
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NCBI chr15:17,360,304...17,367,679
Ensembl chr15:17,360,304...17,367,679
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
[Adenosine co-treated with Homocysteine] affects the reaction [TNF protein affects the localization of RELA protein modified form]; [Adenosine co-treated with Homocysteine] affects the reaction [TNF protein results in increased phosphorylation of RELA protein] |
CTD |
PMID:24224954 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Ren |
renin |
decreases secretion |
EXP |
Adenosine results in decreased secretion of REN protein |
CTD |
PMID:3044993 |
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NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
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G |
Ripk1 |
receptor interacting serine/threonine kinase 1 |
multiple interactions |
ISO |
[Adenosine co-treated with Homocysteine co-treated with TNF protein] results in increased cleavage of RIPK1 protein |
CTD |
PMID:24224954 |
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NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824
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G |
Rps6kb1 |
ribosomal protein S6 kinase B1 |
increases phosphorylation |
ISO |
Adenosine results in increased phosphorylation of RPS6KB1 protein |
CTD |
PMID:34070360 |
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NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
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G |
Slc28a1 |
solute carrier family 28 member 1 |
affects transport multiple interactions |
ISO |
SLC28A1 protein affects the transport of Adenosine Adenosine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine] |
CTD |
PMID:9124315 |
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NCBI chr 1:135,079,375...135,122,791
Ensembl chr 1:135,081,385...135,122,464
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G |
Slc28a2 |
solute carrier family 28 member 2 |
increases transport |
ISO |
SLC28A2 protein results in increased transport of Adenosine |
CTD |
PMID:10087507 |
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NCBI chr 3:109,324,815...109,387,702
Ensembl chr 3:109,366,996...109,387,702
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G |
Slc29a1 |
solute carrier family 29 member 1 |
multiple interactions increases uptake affects abundance |
ISO EXP |
4-nitrobenzylthioinosine inhibits the reaction [SLC29A1 protein alternative form results in increased uptake of Adenosine]; 4-nitrobenzylthioinosine inhibits the reaction [SLC29A1 protein results in increased uptake of Adenosine]; [4-nitrobenzylthioinosine results in decreased activity of SLC29A1 protein] inhibits the reaction [Oxygen deficiency results in increased abundance of Adenosine]; [SLC29A1 co-treated with Oxygen deficiency] affects the abundance of Adenosine; Dipyridamole inhibits the reaction [SLC29A1 protein alternative form results in increased uptake of Adenosine]; Dipyridamole inhibits the reaction [SLC29A1 protein results in increased uptake of Adenosine]; Dipyridamole promotes the reaction [[SLC29A1 co-treated with Oxygen deficiency] affects the abundance of Adenosine] SLC29A1 protein alternative form results in increased uptake of Adenosine; SLC29A1 protein results in increased uptake of Adenosine cilostazol inhibits the reaction [SLC29A1 protein results in increased uptake of Adenosine]; Dipyridamole inhibits the reaction [SLC29A1 protein results in increased uptake of Adenosine]; draflazine inhibits the reaction [SLC29A1 protein results in increased uptake of Adenosine]; Ethanol promotes the reaction [SLC29A1 protein alternative form results in increased uptake of Adenosine]; Ethanol promotes the reaction [SLC29A1 protein results in increased uptake of Adenosine]; Ticagrelor inhibits the reaction [SLC29A1 protein results in increased uptake of Adenosine] Adenosine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine] SLC29A1 affects the abundance of Adenosine |
CTD |
PMID:9353301 PMID:9396714 PMID:11179696 PMID:21283641 PMID:21872611 PMID:23437309 PMID:28041785 More...
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NCBI chr 9:15,399,661...15,414,203
Ensembl chr 9:15,399,612...15,414,203
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G |
Slc29a2 |
solute carrier family 29 member 2 |
increases uptake |
ISO |
SLC29A2 protein results in increased uptake of Adenosine |
CTD |
PMID:9396714 |
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NCBI chr 1:202,327,641...202,335,185
Ensembl chr 1:202,327,354...202,335,171
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G |
Slc29a3 |
solute carrier family 29 member 3 |
affects transport |
ISO |
SLC29A3 protein affects the transport of Adenosine |
CTD |
PMID:19164483 |
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NCBI chr20:28,645,265...28,685,388
Ensembl chr20:28,647,391...28,685,388
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G |
Slc5a5 |
solute carrier family 5 member 5 |
increases expression |
EXP |
Adenosine results in increased expression of SLC5A5 mRNA; Adenosine results in increased expression of SLC5A5 protein |
CTD |
PMID:16954431 |
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NCBI chr16:18,546,709...18,556,698
Ensembl chr16:18,546,709...18,556,697
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G |
Tgfa |
transforming growth factor alpha |
increases secretion |
ISO |
Adenosine results in increased secretion of TGFA protein |
CTD |
PMID:34070360 |
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NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894
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G |
Tgfb1 |
transforming growth factor, beta 1 |
increases expression |
ISO |
Adenosine results in increased expression of TGFB1 mRNA; Adenosine results in increased expression of TGFB1 protein |
CTD |
PMID:34070360 |
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NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Tgfb2 |
transforming growth factor, beta 2 |
increases expression multiple interactions |
ISO |
Adenosine results in increased expression of TGFB2 mRNA Adenosine results in increased expression of and results in increased secretion of TGFB2 protein |
CTD |
PMID:34070360 |
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NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
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G |
Tlr4 |
toll-like receptor 4 |
increases expression affects localization multiple interactions |
ISO |
Adenosine results in increased expression of TLR4 mRNA Adenosine affects the localization of TLR4 protein Adenosine promotes the reaction [lipopolysaccharide, E. coli O26-B6 affects the localization of TLR4 protein] |
CTD |
PMID:21538184 |
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NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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G |
Tnf |
tumor necrosis factor |
multiple interactions decreases expression |
ISO |
5-amino-7-(2-phenylethyl)-2-(2-furyl)pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidine inhibits the reaction [Adenosine inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased secretion of TNF protein]]; [Adenosine co-treated with Homocysteine co-treated with TNF protein] results in increased cleavage of RIPK1 protein; [Adenosine co-treated with Homocysteine] affects the reaction [TNF protein affects the localization of RELA protein modified form]; [Adenosine co-treated with Homocysteine] affects the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; [Adenosine co-treated with Homocysteine] affects the reaction [TNF protein results in increased phosphorylation of RELA protein]; [Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; [Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]; [Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of TNFAIP3 mRNA]; [Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein]; [Adenosine co-treated with Homocysteine] results in increased susceptibility to TNF protein; Adenosine inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of TNF mRNA]; Adenosine inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased secretion of TNF protein]; ZM 241385 inhibits the reaction [Adenosine inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased secretion of TNF protein]] Adenosine results in decreased expression of TNF protein |
CTD |
PMID:11023991 PMID:21538184 PMID:24224954 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tnfaip3 |
TNF alpha induced protein 3 |
multiple interactions |
ISO |
[Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of TNFAIP3 mRNA]; [Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein]; [Adenosine co-treated with Homocysteine] results in decreased expression of TNFAIP3 mRNA; [Adenosine co-treated with Homocysteine] results in decreased expression of TNFAIP3 protein |
CTD |
PMID:24224954 |
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NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282
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G |
Tnfsf10 |
TNF superfamily member 10 |
multiple interactions |
ISO |
[Adenosine co-treated with Coformycin] results in decreased expression of TNFSF10 mRNA |
CTD |
PMID:11992407 |
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NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
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G |
Tp53bp1 |
tumor protein p53 binding protein 1 |
multiple interactions |
ISO |
Adenosine promotes the reaction [Cesium-137 results in increased expression of and affects the localization of TP53BP1 protein] |
CTD |
PMID:32941855 |
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NCBI chr 3:108,166,574...108,270,229
Ensembl chr 3:108,169,980...108,269,822
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G |
Upp1 |
uridine phosphorylase 1 |
increases metabolic processing |
ISO |
UPP1 protein results in increased metabolism of Adenosine |
CTD |
PMID:15772079 |
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NCBI chr14:83,809,495...83,829,299
Ensembl chr14:83,809,960...83,829,462
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G |
Vegfa |
vascular endothelial growth factor A |
multiple interactions increases expression increases secretion |
ISO |
Adenosine promotes the reaction [Dipyridamole results in increased secretion of VEGFA protein]; Adenosine results in increased expression of and results in increased secretion of VEGFA protein Adenosine results in increased expression of VEGFA mRNA Adenosine results in increased secretion of VEGFA protein |
CTD |
PMID:20067761 PMID:34070360 |
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NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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G |
Sult1a1 |
sulfotransferase family 1A member 1 |
multiple interactions |
EXP |
Glutathione Disulfide affects the reaction [adenosine 3'-phosphate-5'-phosphate binds to SULT1A1 protein]; Glutathione Disulfide affects the reaction [Polychlorinated Biphenyls analog affects the reaction [adenosine 3'-phosphate-5'-phosphate binds to SULT1A1 protein]]; Polychlorinated Biphenyls analog affects the reaction [adenosine 3'-phosphate-5'-phosphate binds to SULT1A1 protein] |
CTD |
PMID:21130751 |
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NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
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G |
Sult1e1 |
sulfotransferase family 1E member 1 |
multiple interactions |
ISO |
[2,2',4,4'-tetrabromodiphenyl ether metabolite co-treated with adenosine 3'-phosphate-5'-phosphate] binds to SULT1E1 protein; [Estradiol co-treated with adenosine 3'-phosphate-5'-phosphate] binds to SULT1E1 protein; [tetrabromobisphenol A co-treated with adenosine 3'-phosphate-5'-phosphate] binds to SULT1E1 protein; Estradiol inhibits the reaction [[tetrabromobisphenol A co-treated with adenosine 3'-phosphate-5'-phosphate] binds to SULT1E1 protein]; tetrabromobisphenol A inhibits the reaction [[Estradiol co-treated with adenosine 3'-phosphate-5'-phosphate] binds to SULT1E1 protein] |
CTD |
PMID:23959441 |
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NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275
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G |
Sult2a1 |
sulfotransferase family 2A member 1 |
affects binding multiple interactions |
ISO |
adenosine 3'-phosphate-5'-phosphate binds to SULT2A1 protein Benzoquinones analog inhibits the reaction [adenosine 3'-phosphate-5'-phosphate binds to SULT2A1 protein]; Dehydroepiandrosterone inhibits the reaction [Benzoquinones analog inhibits the reaction [adenosine 3'-phosphate-5'-phosphate binds to SULT2A1 protein]] |
CTD |
PMID:24059442 |
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NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134
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G |
Nudt11 |
nudix hydrolase 11 |
multiple interactions |
ISO |
[NUDT11 protein results in increased metabolism of diadenosine 5',5''''-P1,P6-hexaphosphate] which results in increased chemical synthesis of adenosine 5'-pentaphosphate |
CTD |
PMID:12121577 |
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NCBI chr X:16,326,775...16,333,396
Ensembl chr X:16,326,598...16,333,145
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G |
Cd80 |
Cd80 molecule |
increases expression |
ISO |
adenosine 5'-O-(3-thiotriphosphate) results in increased expression of CD80 protein |
CTD |
PMID:15944274 |
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NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030
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G |
Cd86 |
CD86 molecule |
increases expression |
ISO |
adenosine 5'-O-(3-thiotriphosphate) results in increased expression of CD86 protein |
CTD |
PMID:15944274 |
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NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
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G |
Il10 |
interleukin 10 |
decreases expression |
ISO |
adenosine 5'-O-(3-thiotriphosphate) results in decreased expression of IL10 protein |
CTD |
PMID:15944274 |
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NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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G |
Il12b |
interleukin 12B |
increases expression |
ISO |
adenosine 5'-O-(3-thiotriphosphate) results in increased expression of IL12B protein |
CTD |
PMID:15944274 |
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NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
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G |
Il1b |
interleukin 1 beta |
increases expression |
ISO |
adenosine 5'-O-(3-thiotriphosphate) results in increased expression of IL1B protein |
CTD |
PMID:15944274 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
P2rx7 |
purinergic receptor P2X 7 |
affects response to substance |
ISO |
P2RX7 protein affects the susceptibility to adenosine 5'-O-(3-thiotriphosphate) |
CTD |
PMID:12873706 |
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NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619
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G |
Ptgdr |
prostaglandin D2 receptor |
multiple interactions |
ISO |
adenosine 5'-O-(3-thiotriphosphate) inhibits the reaction [Prostaglandin D2 binds to PTGDR protein] |
CTD |
PMID:9579725 |
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NCBI chr15:17,360,304...17,367,679
Ensembl chr15:17,360,304...17,367,679
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G |
Trpv1 |
transient receptor potential cation channel, subfamily V, member 1 |
increases activity multiple interactions |
EXP |
adenosine 5'-O-(3-thiotriphosphate) results in increased activity of TRPV1 protein Capsaicin promotes the reaction [adenosine 5'-O-(3-thiotriphosphate) results in increased activity of TRPV1 protein]; capsazepine inhibits the reaction [adenosine 5'-O-(3-thiotriphosphate) results in increased activity of TRPV1 protein] |
CTD |
PMID:11140687 |
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NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
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G |
Abcc9 |
ATP binding cassette subfamily C member 9 |
multiple interactions |
ISO |
Adenosine Monophosphate inhibits the reaction [Adenosine Triphosphate results in decreased activity of [KCNJ11 protein binds to ABCC9 protein]]; Creatine metabolite inhibits the reaction [Adenosine Monophosphate inhibits the reaction [Adenosine Triphosphate results in decreased activity of [KCNJ11 protein binds to ABCC9 protein]]] |
CTD |
PMID:11390963 |
|
NCBI chr 4:175,531,854...175,655,849
Ensembl chr 4:175,532,547...175,655,356
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G |
Aldh1a1 |
aldehyde dehydrogenase 1 family, member A1 |
multiple interactions |
ISO |
[4-dimethylaminocinnamaldehyde co-treated with Adenosine Monophosphate] binds to ALDH1A1 protein |
CTD |
PMID:10609638 |
|
NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
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G |
Ercc6 |
ERCC excision repair 6, chromatin remodeling factor |
increases abundance |
ISO |
ERCC6 gene mutant form results in increased abundance of Adenosine Monophosphate |
CTD |
PMID:25440059 |
|
NCBI chr16:7,764,983...7,835,587
Ensembl chr16:7,765,013...7,835,587
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G |
H2ax |
H2A.X variant histone |
multiple interactions |
ISO |
Adenosine Monophosphate promotes the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form] |
CTD |
PMID:32941855 |
|
NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
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G |
Kcnj11 |
potassium inwardly-rectifying channel, subfamily J, member 11 |
multiple interactions |
ISO |
Adenosine Monophosphate inhibits the reaction [Adenosine Triphosphate results in decreased activity of [KCNJ11 protein binds to ABCC9 protein]]; Creatine metabolite inhibits the reaction [Adenosine Monophosphate inhibits the reaction [Adenosine Triphosphate results in decreased activity of [KCNJ11 protein binds to ABCC9 protein]]] |
CTD |
PMID:11390963 |
|
NCBI chr 1:96,591,048...96,594,574
Ensembl chr 1:96,591,049...96,594,082
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G |
Nudt11 |
nudix hydrolase 11 |
multiple interactions |
ISO |
[NUDT11 protein results in increased metabolism of diadenosine 5',5''''-P1,P6-hexaphosphate] which results in increased chemical synthesis of Adenosine Monophosphate; [NUDT11 protein results in increased metabolism of P(1),P(5)-di(adenosine-5'-)pentaphosphate] which results in increased chemical synthesis of Adenosine Monophosphate |
CTD |
PMID:12121577 |
|
NCBI chr X:16,326,775...16,333,396
Ensembl chr X:16,326,598...16,333,145
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G |
Ppargc1a |
PPARG coactivator 1 alpha |
increases expression |
ISO |
Adenosine Monophosphate results in increased expression of PPARGC1A mRNA |
CTD |
PMID:23056435 |
|
NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
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G |
Tp53bp1 |
tumor protein p53 binding protein 1 |
multiple interactions |
ISO |
Adenosine Monophosphate promotes the reaction [Cesium-137 results in increased expression of and affects the localization of TP53BP1 protein] |
CTD |
PMID:32941855 |
|
NCBI chr 3:108,166,574...108,270,229
Ensembl chr 3:108,169,980...108,269,822
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G |
Tp73 |
tumor protein p73 |
affects abundance |
ISO |
TP73 protein affects the abundance of Adenosine Monophosphate |
CTD |
PMID:25554796 |
|
NCBI chr 5:164,621,377...164,703,958
Ensembl chr 5:164,621,377...164,681,128
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G |
Abcc1 |
ATP binding cassette subfamily C member 1 |
multiple interactions affects binding |
ISO |
estradiol-17 beta-glucuronide inhibits the reaction [Adenosine Diphosphate binds to ABCC1 protein mutant form]; estradiol-17 beta-glucuronide inhibits the reaction [Adenosine Diphosphate binds to ABCC1 protein]; Vanadates promotes the reaction [Adenosine Diphosphate binds to ABCC1 protein] Adenosine Diphosphate binds to ABCC1 protein; Adenosine Diphosphate binds to ABCC1 protein mutant form |
CTD |
PMID:18336795 |
|
NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
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G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions |
EXP |
Adenosine Diphosphate affects the folding of [Tetrachlorodibenzodioxin binds to AHR protein] |
CTD |
PMID:1848756 |
|
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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G |
Ak1 |
adenylate kinase 1 |
increases abundance |
ISO |
AK1 protein results in increased abundance of Adenosine Diphosphate |
CTD |
PMID:11390963 |
|
NCBI chr 3:15,912,431...15,923,045
Ensembl chr 3:15,912,485...15,923,041
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G |
Alb |
albumin |
decreases secretion multiple interactions |
ISO |
Adenosine Diphosphate results in decreased secretion of ALB protein Aspirin inhibits the reaction [Adenosine Diphosphate results in decreased secretion of ALB protein] |
CTD |
PMID:17303692 |
|
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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G |
App |
amyloid beta precursor protein |
multiple interactions increases abundance |
ISO |
PF-06840003 inhibits the reaction [APP protein mutant form results in increased abundance of Adenosine Diphosphate] [APP protein mutant form co-treated with PSEN1 protein mutant form] results in increased abundance of Adenosine Diphosphate; PF-06840003 inhibits the reaction [[APP protein mutant form co-treated with PSEN1 protein mutant form] results in increased abundance of Adenosine Diphosphate] |
CTD |
PMID:39172838 |
|
NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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G |
Axl |
Axl receptor tyrosine kinase |
decreases response to substance |
ISO |
AXL protein results in decreased susceptibility to Adenosine Diphosphate |
CTD |
PMID:15733062 |
|
NCBI chr 1:81,265,088...81,296,278
Ensembl chr 1:81,265,088...81,296,265
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G |
Cat |
catalase |
multiple interactions |
EXP |
CAT protein inhibits the reaction [Adenosine Diphosphate results in increased glutathionylation of PTPN1 protein] |
CTD |
PMID:16781456 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Cd40lg |
CD40 ligand |
increases expression multiple interactions |
ISO |
Adenosine Diphosphate results in increased expression of CD40LG protein clopidogrel inhibits the reaction [Adenosine Diphosphate results in increased expression of CD40LG protein] |
CTD |
PMID:11297035 PMID:17043144 |
|
NCBI chr X:135,127,052...135,138,768
Ensembl chr X:135,126,969...135,138,306
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G |
Cftr |
CF transmembrane conductance regulator |
multiple interactions |
ISO |
Adenosine Diphosphate binds to and results in decreased activity of CFTR protein; P(1),P(5)-di(adenosine-5'-)pentaphosphate inhibits the reaction [Adenosine Diphosphate binds to and results in decreased activity of CFTR protein] |
CTD |
PMID:15684079 |
|
NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
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G |
Chordc1 |
cysteine and histidine rich domain containing 1 |
multiple interactions |
ISO |
Adenosine Diphosphate binds to and affects the folding of CHORDC1 protein; Adenosine Diphosphate promotes the reaction [CHORDC1 protein binds to CHORDC1 protein]; Adenosine Diphosphate promotes the reaction [ITGB1BP2 protein binds to CHORDC1 protein] |
CTD |
PMID:23184943 |
|
NCBI chr 8:15,374,356...15,398,436
Ensembl chr 8:15,374,471...15,399,162
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G |
Cyp2c6 |
cytochrome P450, family 2, subfamily C, polypeptide 6 |
multiple interactions |
ISO |
CYP2C19 gene affects the susceptibility to [Adenosine Diphosphate co-treated with clopidogrel]; CYP2C19 gene SNP affects the reaction [Adenosine Diphosphate results in increased expression of SELP protein]; CYP2C19 gene SNP affects the susceptibility to [Adenosine Diphosphate co-treated with Arachidonic Acid] |
CTD |
PMID:16772608 PMID:18004210 PMID:18394438 |
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NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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G |
Dtymk |
deoxythymidylate kinase |
multiple interactions |
ISO |
DTYMK protein binds to [N1-(4-bis(pivaloyloxymethyl)phosphinylbuten-2-yl)thymine co-treated with Adenosine Diphosphate] |
CTD |
PMID:21128666 |
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NCBI chr 9:94,315,552...94,324,386
Ensembl chr 9:94,315,552...94,324,870
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G |
Dusp1 |
dual specificity phosphatase 1 |
multiple interactions |
ISO |
Adenosine Diphosphate inhibits the reaction [Cesium-137 results in increased expression of DUSP1 protein]; Anthraquinones analog inhibits the reaction [Adenosine Diphosphate promotes the reaction [Cesium-137 results in decreased expression of DUSP1 protein]] |
CTD |
PMID:32941855 |
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NCBI chr10:16,680,478...16,683,275
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G |
Dusp6 |
dual specificity phosphatase 6 |
multiple interactions |
ISO |
Adenosine Diphosphate inhibits the reaction [Cesium-137 results in increased expression of DUSP6 protein]; Anthraquinones analog inhibits the reaction [Adenosine Diphosphate promotes the reaction [Cesium-137 results in decreased expression of DUSP6 protein]] |
CTD |
PMID:32941855 |
|
NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185
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G |
Epha4 |
Eph receptor A4 |
increases phosphorylation multiple interactions |
ISO |
Adenosine Diphosphate results in increased phosphorylation of EPHA4 protein Benzoic Acid analog inhibits the reaction [Adenosine Diphosphate results in increased phosphorylation of EPHA4 protein] |
CTD |
PMID:22273509 |
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NCBI chr 9:78,815,460...78,958,139
Ensembl chr 9:78,815,460...78,958,139
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G |
Ern1 |
endoplasmic reticulum to nucleus signaling 1 |
multiple interactions decreases activity |
ISO |
Adenosine Diphosphate inhibits the reaction [ERN1 protein binds to ERN1 protein] Adenosine Diphosphate results in decreased activity of ERN1 protein |
CTD |
PMID:25164867 |
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NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
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G |
F2 |
coagulation factor II, thrombin |
increases abundance multiple interactions |
ISO |
F2 protein results in increased abundance of Adenosine Diphosphate Quercetin inhibits the reaction [F2 protein results in increased abundance of Adenosine Diphosphate]; resveratrol inhibits the reaction [F2 protein results in increased abundance of Adenosine Diphosphate] |
CTD |
PMID:15342215 |
|
NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
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G |
Fga |
fibrinogen alpha chain |
multiple interactions increases secretion |
ISO |
Aspirin promotes the reaction [Adenosine Diphosphate results in increased secretion of FGA protein] |
CTD |
PMID:17303692 |
|
NCBI chr 2:168,374,120...168,381,523
Ensembl chr 2:168,374,120...168,381,528
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G |
Fgb |
fibrinogen beta chain |
decreases secretion multiple interactions |
ISO |
Adenosine Diphosphate results in decreased secretion of FGB protein Aspirin inhibits the reaction [Adenosine Diphosphate results in decreased secretion of FGB protein] |
CTD |
PMID:17303692 |
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NCBI chr 2:168,394,901...168,402,863
Ensembl chr 2:168,394,916...168,405,979
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G |
Fgg |
fibrinogen gamma chain |
increases secretion multiple interactions |
ISO |
Adenosine Diphosphate results in increased secretion of FGG protein Aspirin promotes the reaction [Adenosine Diphosphate results in increased secretion of FGG protein] |
CTD |
PMID:17303692 |
|
NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322
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G |
Gapdh |
glyceraldehyde-3-phosphate dehydrogenase |
multiple interactions |
ISO |
Adenosine Diphosphate inhibits the reaction [[GAPDH protein co-treated with NAD co-treated with Glyceraldehyde 3-Phosphate co-treated with Glutathione] results in increased reduction of sodium arsenite analog] |
CTD |
PMID:15788719 |
|
NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
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G |
Gas6 |
growth arrest specific 6 |
increases response to substance |
ISO |
GAS6 protein results in increased susceptibility to Adenosine Diphosphate |
CTD |
PMID:15733062 |
|
NCBI chr16:76,045,430...76,075,904
Ensembl chr16:76,045,426...76,075,904
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G |
H2ax |
H2A.X variant histone |
multiple interactions |
ISO |
Adenosine Diphosphate promotes the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form]; Anthraquinones analog inhibits the reaction [Adenosine Diphosphate promotes the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form]]; U 0126 inhibits the reaction [Adenosine Diphosphate promotes the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form]] |
CTD |
PMID:32941855 |
|
NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
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G |
Hras |
HRas proto-oncogene, GTPase |
multiple interactions |
ISO |
Adenosine Diphosphate binds to and affects the folding of HRAS protein |
CTD |
PMID:16388579 |
|
NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
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G |
Hsp90aa1 |
heat shock protein 90 alpha family class A member 1 |
multiple interactions |
ISO |
Adenosine Diphosphate promotes the reaction [ITGB1BP2 protein binds to HSP90AA1 protein]; Calcium promotes the reaction [Adenosine Diphosphate promotes the reaction [ITGB1BP2 protein binds to HSP90AA1 protein]] |
CTD |
PMID:23184943 |
|
NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
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G |
Idh2 |
isocitrate dehydrogenase (NADP(+)) 2 |
multiple interactions increases abundance |
ISO |
Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Adenosine Diphosphate] |
CTD |
PMID:27469509 |
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NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025
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G |
Il6 |
interleukin 6 |
increases expression multiple interactions |
ISO |
Adenosine Diphosphate results in increased expression of IL6 protein MRS 2211 inhibits the reaction [Adenosine Diphosphate results in increased expression of IL6 protein] |
CTD |
PMID:24849676 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Itga2 |
integrin subunit alpha 2 |
multiple interactions |
ISO |
ITGA2 gene SNP affects the susceptibility to [Aspirin co-treated with clopidogrel co-treated with Adenosine Diphosphate] |
CTD |
PMID:16214444 |
|
NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481
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G |
Itga2b |
integrin subunit alpha 2b |
multiple interactions |
ISO |
cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]; N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]; N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate promotes the reaction [cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]] |
CTD |
PMID:18404433 |
|
NCBI chr10:87,408,532...87,426,055
Ensembl chr10:87,408,536...87,426,168
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G |
Itgb1bp2 |
integrin subunit beta 1 binding protein 2 |
multiple interactions |
ISO |
Adenosine Diphosphate promotes the reaction [ITGB1BP2 protein binds to CHORDC1 protein]; Adenosine Diphosphate promotes the reaction [ITGB1BP2 protein binds to HSP90AA1 protein]; Adenosine Diphosphate promotes the reaction [ITGB1BP2 protein binds to ITGB1BP2 protein]; Calcium promotes the reaction [Adenosine Diphosphate promotes the reaction [ITGB1BP2 protein binds to HSP90AA1 protein]] |
CTD |
PMID:23184943 |
|
NCBI chr X:66,572,537...66,577,174
Ensembl chr X:66,572,537...66,577,174
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G |
Itgb3 |
integrin subunit beta 3 |
multiple interactions |
ISO |
cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]; N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]; N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate promotes the reaction [cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]] |
CTD |
PMID:18404433 |
|
NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679
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G |
Mapk1 |
mitogen activated protein kinase 1 |
increases phosphorylation multiple interactions |
ISO |
Adenosine Diphosphate results in increased phosphorylation of MAPK1 protein Anthraquinones analog inhibits the reaction [Adenosine Diphosphate promotes the reaction [Cesium-137 results in increased phosphorylation of MAPK1 protein]] |
CTD |
PMID:15034929 PMID:32941855 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
increases phosphorylation multiple interactions |
ISO |
Adenosine Diphosphate results in increased phosphorylation of MAPK3 protein Anthraquinones analog inhibits the reaction [Adenosine Diphosphate promotes the reaction [Cesium-137 results in increased phosphorylation of MAPK3 protein]] |
CTD |
PMID:15034929 PMID:32941855 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
ISO |
Dicumarol inhibits the reaction [Adenosine Diphosphate results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:24466103 |
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NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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G |
Mapk9 |
mitogen-activated protein kinase 9 |
multiple interactions |
ISO |
Dicumarol inhibits the reaction [Adenosine Diphosphate results in increased phosphorylation of MAPK9 protein] |
CTD |
PMID:24466103 |
|
NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
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G |
Mapt |
microtubule-associated protein tau |
multiple interactions increases abundance |
ISO |
PF-06840003 inhibits the reaction [MAPT protein mutant form results in increased abundance of Adenosine Diphosphate] |
CTD |
PMID:39172838 |
|
NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
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G |
Mertk |
MER proto-oncogene, tyrosine kinase |
increases response to substance |
ISO |
MERTK protein results in increased susceptibility to Adenosine Diphosphate |
CTD |
PMID:15733062 |
|
NCBI chr 3:115,939,351...116,045,141
Ensembl chr 3:115,939,351...116,046,554
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
NOS2 protein affects the susceptibility to [Phenylephrine co-treated with Adenosine Diphosphate] |
CTD |
PMID:11498454 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nt5e |
5' nucleotidase, ecto |
decreases activity |
ISO |
Adenosine Diphosphate analog results in decreased activity of NT5E protein |
CTD |
PMID:18404487 |
|
NCBI chr 8:89,271,046...89,314,918
Ensembl chr 8:89,270,696...89,314,881
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G |
P2ry12 |
purinergic receptor P2Y12 |
affects response to substance increases response to substance multiple interactions |
ISO EXP |
P2RY12 gene polymorphism affects the susceptibility to Adenosine Diphosphate; P2RY12 protein affects the susceptibility to Adenosine Diphosphate P2RY12 protein results in increased susceptibility to Adenosine Diphosphate Epinephrine inhibits the reaction [P2RY12 gene mutant form results in decreased susceptibility to Adenosine Diphosphate] P2RY12 protein affects the reaction [Adenosine Diphosphate analog results in increased expression of SELP protein] |
CTD |
PMID:11196645 PMID:11413167 PMID:18404433 PMID:23849096 |
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NCBI chr 2:143,481,468...143,523,340
Ensembl chr 2:143,481,430...143,523,361
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G |
Pdgfb |
platelet derived growth factor subunit B |
increases secretion multiple interactions |
ISO |
Adenosine Diphosphate results in increased secretion of PDGFB protein Aspirin promotes the reaction [Adenosine Diphosphate results in increased secretion of PDGFB protein] |
CTD |
PMID:17303692 |
|
NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
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G |
Pf4 |
platelet factor 4 |
increases secretion multiple interactions |
ISO |
Adenosine Diphosphate results in increased secretion of PF4 protein silidianin inhibits the reaction [Adenosine Diphosphate results in increased secretion of PF4 protein]; Silybin inhibits the reaction [Adenosine Diphosphate results in increased secretion of PF4 protein]; silychristin inhibits the reaction [Adenosine Diphosphate results in increased secretion of PF4 protein] |
CTD |
PMID:19428933 PMID:29439388 |
|
NCBI chr14:17,298,304...17,299,220
Ensembl chr14:17,298,308...17,299,365
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G |
Pfkm |
phosphofructokinase, muscle |
multiple interactions |
ISO |
Adenosine Diphosphate inhibits the reaction [resveratrol results in decreased activity of PFKM protein] |
CTD |
PMID:23454376 |
|
NCBI chr 7:129,221,679...129,259,192
Ensembl chr 7:129,221,653...129,259,192
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G |
Pgp |
phosphoglycolate phosphatase |
decreases phosphorylation |
ISO |
PGP protein results in decreased phosphorylation of Adenosine Diphosphate |
CTD |
PMID:24338473 |
|
NCBI chr10:13,495,232...13,497,858
Ensembl chr10:13,494,291...13,497,858
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G |
Ppbp |
pro-platelet basic protein |
increases secretion |
ISO |
Adenosine Diphosphate results in increased secretion of PPBP protein |
CTD |
PMID:19428933 |
|
NCBI chr14:17,302,326...17,303,130
Ensembl chr14:17,302,326...17,303,130
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G |
Ppp5c |
protein phosphatase 5, catalytic subunit |
multiple interactions |
ISO |
Adenosine Diphosphate binds to and affects the folding of PPP5C protein |
CTD |
PMID:23184943 |
|
NCBI chr 1:77,690,203...77,714,507
Ensembl chr 1:77,690,208...77,714,456
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G |
Psen1 |
presenilin 1 |
multiple interactions |
ISO |
[APP protein mutant form co-treated with PSEN1 protein mutant form] results in increased abundance of Adenosine Diphosphate; PF-06840003 inhibits the reaction [[APP protein mutant form co-treated with PSEN1 protein mutant form] results in increased abundance of Adenosine Diphosphate] |
CTD |
PMID:39172838 |
|
NCBI chr 6:103,323,052...103,375,088
Ensembl chr 6:103,323,120...103,371,650
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G |
Ptpn1 |
protein tyrosine phosphatase, non-receptor type 1 |
increases glutathionylation multiple interactions |
EXP |
Adenosine Diphosphate results in increased glutathionylation of PTPN1 protein CAT protein inhibits the reaction [Adenosine Diphosphate results in increased glutathionylation of PTPN1 protein] |
CTD |
PMID:16781456 |
|
NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504
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G |
Selp |
selectin P |
multiple interactions increases expression |
ISO |
cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of SELP protein]; CYP2C19 gene SNP affects the reaction [Adenosine Diphosphate results in increased expression of SELP protein]; Heparin promotes the reaction [Adenosine Diphosphate affects the localization of SELP protein]; N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate inhibits the reaction [Adenosine Diphosphate analog results in increased expression of SELP protein]; N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate promotes the reaction [cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of SELP protein]]; P2RY12 protein affects the reaction [Adenosine Diphosphate analog results in increased expression of SELP protein]; Quercetin inhibits the reaction [Adenosine Diphosphate results in increased expression of SELP protein] |
CTD |
PMID:9740346 PMID:18394438 PMID:18404433 PMID:23249183 |
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NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845
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G |
Sirt3 |
sirtuin 3 |
decreases abundance |
ISO |
SIRT3 protein results in decreased abundance of Adenosine Diphosphate |
CTD |
PMID:23166782 |
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NCBI chr 1:195,942,066...195,964,472
Ensembl chr 1:195,942,073...195,964,808
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G |
Taldo1 |
transaldolase 1 |
increases abundance |
ISO |
TALDO1 gene mutant form results in increased abundance of Adenosine Diphosphate |
CTD |
PMID:19436114 |
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NCBI chr 1:196,493,634...196,503,965
Ensembl chr 1:196,493,589...196,503,974
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G |
Thbs1 |
thrombospondin 1 |
increases secretion |
ISO |
Adenosine Diphosphate results in increased secretion of THBS1 protein |
CTD |
PMID:17303692 |
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NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440
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G |
Tp53bp1 |
tumor protein p53 binding protein 1 |
multiple interactions |
ISO |
Adenosine Diphosphate promotes the reaction [Cesium-137 results in increased expression of and affects the localization of TP53BP1 protein]; Anthraquinones analog inhibits the reaction [Adenosine Diphosphate promotes the reaction [Cesium-137 results in increased expression of and affects the localization of TP53BP1 protein]]; U 0126 inhibits the reaction [Adenosine Diphosphate promotes the reaction [Cesium-137 results in increased expression of and affects the localization of TP53BP1 protein]] |
CTD |
PMID:32941855 |
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NCBI chr 3:108,166,574...108,270,229
Ensembl chr 3:108,169,980...108,269,822
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G |
Tyro3 |
TYRO3 protein tyrosine kinase |
increases response to substance |
ISO |
TYRO3 protein results in increased susceptibility to Adenosine Diphosphate |
CTD |
PMID:15733062 |
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NCBI chr 3:106,777,686...106,797,154
Ensembl chr 3:106,777,635...106,797,142
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G |
Vasp |
vasodilator-stimulated phosphoprotein |
increases phosphorylation multiple interactions |
ISO |
Adenosine Diphosphate results in increased phosphorylation of VASP protein N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Adenosine Diphosphate results in increased phosphorylation of VASP protein] |
CTD |
PMID:25329809 |
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NCBI chr 1:78,910,009...78,925,791
Ensembl chr 1:78,910,011...78,925,061
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G |
Adprh |
ADP-ribosylarginine hydrolase |
increases hydrolysis |
ISO |
ADPRH protein results in increased hydrolysis of Adenosine Diphosphate Ribose metabolite |
CTD |
PMID:21498885 |
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NCBI chr11:62,299,831...62,306,170
Ensembl chr11:62,299,793...62,306,931
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G |
Adprs |
ADP-ribosylserine hydrolase |
increases hydrolysis multiple interactions |
ISO |
ADPRS protein results in increased hydrolysis of Adenosine Diphosphate Ribose metabolite Adenosine Diphosphate Ribose inhibits the reaction [ADPRS protein results in increased hydrolysis of O-Acetyl-ADP-Ribose] |
CTD |
PMID:21498885 |
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NCBI chr 5:138,614,022...138,619,296
Ensembl chr 5:138,614,022...138,619,296
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G |
Nos1 |
nitric oxide synthase 1 |
multiple interactions |
ISO |
NOS1 protein affects the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased ribosylation of Adenosine Diphosphate Ribose] |
CTD |
PMID:10318960 |
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NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
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G |
Trpm2 |
transient receptor potential cation channel, subfamily M, member 2 |
multiple interactions increases activity |
EXP ISO |
Adenosine Diphosphate Ribose promotes the reaction [TRPM2 protein results in increased transport of Calcium]; Clotrimazole inhibits the reaction [Adenosine Diphosphate Ribose promotes the reaction [TRPM2 protein results in increased transport of Calcium]]; Flufenamic Acid inhibits the reaction [Adenosine Diphosphate Ribose promotes the reaction [TRPM2 protein results in increased transport of Calcium]] Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein 2-aminoethoxydiphenyl borate inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; 4-amylcinnamoylanthranilic acid inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; 4-amylcinnamoylanthranilic acid inhibits the reaction [Cisplatin promotes the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]]; 4-amylcinnamoylanthranilic acid inhibits the reaction [Eicosapentaenoic Acid promotes the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]]; 4-amylcinnamoylanthranilic acid inhibits the reaction [Eicosapentaenoic Acid promotes the reaction [Cisplatin promotes the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]]]; Cisplatin promotes the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; Copper Sulfate inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; Eicosapentaenoic Acid promotes the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; Eicosapentaenoic Acid promotes the reaction [Cisplatin promotes the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]]; ferrous chloride inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; lead nitrate inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; Mercuric Chloride inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; Miconazole inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; Selenium Oxides inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein] 4-amylcinnamoylanthranilic acid inhibits the reaction [[Buthionine Sulfoximine co-treated with Adenosine Diphosphate Ribose] results in increased activity of TRPM2 protein]; 4-amylcinnamoylanthranilic acid inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; [Buthionine Sulfoximine co-treated with Adenosine Diphosphate Ribose] results in increased activity of TRPM2 protein; Glutathione inhibits the reaction [[Buthionine Sulfoximine co-treated with Adenosine Diphosphate Ribose] results in increased activity of TRPM2 protein]; Glutathione inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; TRPM2 protein promotes the reaction [Adenosine Diphosphate Ribose results in increased uptake of Calcium] |
CTD |
PMID:18204483 PMID:20878536 PMID:21900507 PMID:22750002 PMID:33309544 PMID:35395232 More...
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NCBI chr20:10,703,568...10,753,189
Ensembl chr20:10,707,014...10,753,181
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G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions |
EXP |
Adenylyl Imidodiphosphate affects the folding of [Tetrachlorodibenzodioxin binds to AHR protein] |
CTD |
PMID:1848756 |
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NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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G |
Cftr |
CF transmembrane conductance regulator |
affects activity |
ISO |
Adenylyl Imidodiphosphate affects the activity of CFTR protein |
CTD |
PMID:15657297 |
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NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
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G |
Csnk2a1 |
casein kinase 2 alpha 1 |
affects binding |
ISO |
Adenylyl Imidodiphosphate binds to CSNK2A1 protein |
CTD |
PMID:34344863 |
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NCBI chr 3:140,709,984...140,756,757
Ensembl chr 3:140,709,991...140,756,696
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G |
Ptgdr |
prostaglandin D2 receptor |
multiple interactions |
ISO |
Adenylyl Imidodiphosphate inhibits the reaction [Prostaglandin D2 binds to PTGDR protein] |
CTD |
PMID:9579725 |
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NCBI chr15:17,360,304...17,367,679
Ensembl chr15:17,360,304...17,367,679
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G |
Ppara |
peroxisome proliferator activated receptor alpha |
multiple interactions |
ISO |
arachidonyl-coenzyme A binds to and results in increased activity of PPARA protein |
CTD |
PMID:11139385 |
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NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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G |
Abca8 |
ATP binding cassette subfamily A member 8 |
multiple interactions |
ISO |
Adenosine Triphosphate affects the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide] |
CTD |
PMID:12379217 |
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NCBI chr10:94,917,520...94,991,199
Ensembl chr10:94,917,520...94,990,988
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G |
Abcb11 |
ATP binding cassette subfamily B member 11 |
multiple interactions |
ISO EXP |
Adenosine Triphosphate promotes the reaction [ABCB11 protein results in increased uptake of fexofenadine] |
CTD |
PMID:18245269 |
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NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
multiple interactions affects binding increases hydrolysis |
ISO EXP |
[Cobalt results in increased activity of ABCB1 protein] which results in increased hydrolysis of Adenosine Triphosphate; [Magnesium results in increased activity of ABCB1 protein] which results in increased hydrolysis of Adenosine Triphosphate; [Manganese results in increased activity of ABCB1 protein] which results in increased hydrolysis of Adenosine Triphosphate; ABCB1 protein binds to and results in increased hydrolysis of Adenosine Triphosphate; aurapten promotes the reaction [ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate]; crizotinib promotes the reaction [ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate]; Disulfiram affects the reaction [ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate]; lapatinib promotes the reaction [ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate]; nobiletin promotes the reaction [ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate] Adenosine Triphosphate binds to ABCB1 protein [Rifampin metabolite results in decreased activity of ABCB1A protein] which results in decreased abundance of Adenosine Triphosphate |
CTD |
PMID:2900677 PMID:14978246 PMID:18829547 PMID:18955043 PMID:22233293 PMID:23685082 PMID:32497533 More...
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Abcc1 |
ATP binding cassette subfamily C member 1 |
multiple interactions affects activity increases hydrolysis affects binding |
ISO |
[Adenosine Triphosphate affects the activity of ABCC1 protein] which results in increased transport of Acetaminophen metabolite; ABCC1 protein binds to and results in increased degradation of Adenosine Triphosphate; ABCC1 protein binds to and results in increased hydrolysis of Adenosine Triphosphate; ABCC1 protein mutant form binds to and results in increased hydrolysis of Adenosine Triphosphate; Adenosine Triphosphate binds to and affects the folding of ABCC1 protein; Adenosine Triphosphate promotes the reaction [ABCC1 protein affects the transport of Bilirubin]; Adenosine Triphosphate promotes the reaction [ABCC1 protein affects the transport of estradiol-17 beta-glucuronide]; Adenosine Triphosphate promotes the reaction [ABCC1 protein affects the transport of Leukotriene C4]; daidzein promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; Disulfiram affects the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; hesperetin promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; naringenin promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; nobiletin promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; Quercetin affects the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; Resveratrol promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; Silymarin inhibits the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate] Daunorubicin promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; Vanadates inhibits the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate] Adenosine Triphosphate binds to ABCC1 protein |
CTD |
PMID:10856430 PMID:11278000 PMID:14978246 PMID:15245331 PMID:15355964 PMID:15459206 PMID:15737336 PMID:15838832 PMID:16156793 PMID:18336795 PMID:18955043 PMID:32472168 More...
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NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
multiple interactions affects activity affects metabolic processing |
EXP ISO |
Adenosine Triphosphate promotes the reaction [ABCC2 protein results in increased secretion of Fluo-3]; Adenosine Triphosphate promotes the reaction [ABCC2 protein results in increased transport of temocaprilat] Adenosine Triphosphate affects the activity of ABCC2 protein [Adenosine Triphosphate affects the activity of ABCC2 protein] which results in increased transport of Acetaminophen metabolite; [Adenosine Triphosphate co-treated with ABCC2 protein] results in increased uptake of estradiol-17 beta-glucuronide; Adenosine Triphosphate affects the reaction [ABCC2 protein results in increased transport of Mercury]; verlukast inhibits the reaction [[Adenosine Triphosphate co-treated with ABCC2 protein] results in increased uptake of estradiol-17 beta-glucuronide] ABCC2 protein affects the metabolism of Adenosine Triphosphate Adenosine Triphosphate promotes the reaction [ABCC2 protein results in increased transport of S-1,2-dichlorovinyl-N-acetylcysteine] |
CTD |
PMID:9067317 PMID:9794919 PMID:20060011 PMID:22027652 PMID:24039982 PMID:32003934 PMID:32472168 More...
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NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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G |
Abcc3 |
ATP binding cassette subfamily C member 3 |
multiple interactions |
ISO |
Adenosine Triphosphate promotes the reaction [ABCC3 protein affects the transport of fexofenadine] |
CTD |
PMID:18245269 |
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NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
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