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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:N-acyldiazepane
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Accession:CHEBI:46945 term browser browse the term
Synonyms:related_synonym: N-acyldiazepanes


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fasudil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle decreases expression ISO fasudil results in decreased expression of ACTA2 mRNA CTD PMID:22465603 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP fasudil results in increased phosphorylation of and results in increased activity of AKT1 protein CTD PMID:17761835 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Arg1 arginase 1 increases expression EXP fasudil results in increased expression of ARG1 protein CTD PMID:30462329 NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422 		JBrowse link
G Arhgef11 Rho guanine nucleotide exchange factor 11 decreases expression ISO fasudil results in decreased expression of ARHGEF11 mRNA; fasudil results in decreased expression of ARHGEF11 protein CTD PMID:26172442 NCBI chr 2:173,074,383...173,195,962
Ensembl chr 2:173,074,368...173,196,010 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP fasudil inhibits the reaction [Paraquat results in increased expression of BAX mRNA]; fasudil inhibits the reaction [Streptozocin results in increased expression of BAX protein] CTD PMID:22429817 PMID:30088170 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression		 EXP fasudil inhibits the reaction [Paraquat results in decreased expression of BCL2 mRNA]; fasudil inhibits the reaction [Streptozocin results in decreased expression of BCL2 protein]
fasudil results in increased expression of BCL2 protein		 CTD PMID:17761835 PMID:22429817 PMID:30088170 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bglap bone gamma-carboxyglutamate protein multiple interactions ISO 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with Ascorbic Acid] co-treated with fasudil] results in increased expression of BGLAP mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with Ascorbic Acid] co-treated with fasudil] results in increased expression of BGLAP protein]; [[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with Ascorbic Acid] co-treated with fasudil] results in increased expression of BGLAP mRNA; [[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with Ascorbic Acid] co-treated with fasudil] results in increased expression of BGLAP protein CTD PMID:31935364 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP fasudil inhibits the reaction [Carbon Tetrachloride results in increased activity of CASP3 protein]; fasudil inhibits the reaction [Paraquat results in increased expression of CASP3 mRNA] CTD PMID:17761835 PMID:30088170 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO fasudil inhibits the reaction [Acetaminophen results in increased expression of CCL2 protein] CTD PMID:34078832 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions EXP fasudil affects the reaction [Daunorubicin affects the expression of CDKN1B mRNA] CTD PMID:20037814 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cfl1 cofilin 1 decreases expression
multiple interactions		 ISO
EXP		 fasudil results in decreased expression of CFL1 mRNA
fasudil inhibits the reaction [Streptozocin results in increased phosphorylation of CFL1 protein]
fasudil results in decreased expression of and results in decreased phosphorylation of CFL1 protein		 CTD PMID:22062134 PMID:26172442 NCBI chr 1:202,796,012...202,801,337
Ensembl chr 1:202,786,627...202,817,587 		JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression
multiple interactions		 ISO fasudil results in decreased expression of COL1A1 mRNA
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with Ascorbic Acid] co-treated with fasudil] results in increased expression of COL1A1 mRNA]; [[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with Ascorbic Acid] co-treated with fasudil] results in increased expression of COL1A1 mRNA		 CTD PMID:22465603 PMID:31935364 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Col3a1 collagen type III alpha 1 chain decreases expression ISO fasudil results in decreased expression of COL3A1 mRNA CTD PMID:22465603 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547 		JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP fasudil inhibits the reaction [Streptozocin results in increased expression of FN1 protein] CTD PMID:23376009 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Gap43 growth associated protein 43 multiple interactions EXP [fasudil co-treated with Methylmercury Compounds] results in increased expression of and results in increased phosphorylation of GAP43 protein CTD PMID:30462329 NCBI chr11:58,376,371...58,470,047
Ensembl chr11:58,376,371...58,470,045 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO fasudil inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein] CTD PMID:30831131 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hmox1 heme oxygenase 1 affects expression ISO fasudil affects the expression of HMOX1 protein CTD PMID:26120273 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions EXP fasudil inhibits the reaction [Streptozocin results in increased expression of ICAM1 protein] CTD PMID:23376009 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Il10 interleukin 10 increases expression EXP fasudil results in increased expression of IL10 protein CTD PMID:30462329 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il18 interleukin 18 multiple interactions EXP fasudil inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA] CTD PMID:18660453 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP
ISO		 fasudil inhibits the reaction [Methylmercury Compounds results in increased expression of IL1B protein]; fasudil inhibits the reaction [Paraquat results in increased expression of IL1B protein]
fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B protein]; fasudil inhibits the reaction [Paraquat results in increased secretion of IL1B protein]
fasudil inhibits the reaction [Acetaminophen results in increased expression of IL1B protein]; fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B protein]		 CTD PMID:30088170 PMID:30462329 PMID:30924981 PMID:34078832 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP
ISO		 fasudil inhibits the reaction [Methylmercury Compounds results in increased expression of IL6 protein]; fasudil inhibits the reaction [Paraquat results in increased expression of IL6 protein]
fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein]; fasudil inhibits the reaction [Paraquat results in increased secretion of IL6 protein]
fasudil inhibits the reaction [Acetaminophen results in increased expression of IL6 protein]; fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein]		 CTD PMID:30088170 PMID:30462329 PMID:30924981 PMID:34078832 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Limk2 LIM domain kinase 2 multiple interactions EXP fasudil inhibits the reaction [Streptozocin results in increased phosphorylation of LIMK2 protein] CTD PMID:22062134 NCBI chr14:78,208,182...78,286,106
Ensembl chr14:78,218,063...78,286,007 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 decreases expression ISO fasudil results in decreased expression of MAP3K7 protein CTD PMID:22465603 NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions EXP fasudil inhibits the reaction [methylmercuric chloride results in decreased expression of MAPT protein] CTD PMID:20869980 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G Mmp8 matrix metallopeptidase 8 affects expression ISO fasudil affects the expression of MMP8 mRNA CTD PMID:26120273 NCBI chr 8:4,724,009...4,733,864
Ensembl chr 8:4,724,029...4,733,520 		JBrowse link
G Mmp9 matrix metallopeptidase 9 affects expression ISO fasudil affects the expression of MMP9 mRNA CTD PMID:26120273 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased activity of MPO protein] CTD PMID:30924981 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Myh7 myosin heavy chain 7 decreases expression ISO fasudil results in decreased expression of MYH7 mRNA CTD PMID:22465603 NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217 		JBrowse link
G Myl1 myosin, light chain 1 multiple interactions EXP fasudil inhibits the reaction [Norepinephrine results in increased phosphorylation of MYL1 protein] CTD PMID:37963515 NCBI chr 9:68,437,514...68,458,256
Ensembl chr 9:68,437,517...68,458,261 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP
ISO		 fasudil inhibits the reaction [Streptozocin results in decreased expression of NFKBIA protein]
fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of NFKBIA protein]		 CTD PMID:23376009 PMID:30924981 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP fasudil inhibits the reaction [Methylmercury Compounds results in increased expression of NOS2 protein] CTD PMID:30462329 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nphs1 NPHS1 adhesion molecule, nephrin multiple interactions EXP fasudil inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of NPHS1 protein] CTD PMID:16452496 NCBI chr 1:85,720,812...85,749,079
Ensembl chr 1:85,720,812...85,749,078 		JBrowse link
G Nppa natriuretic peptide A decreases expression ISO fasudil results in decreased expression of NPPA mRNA CTD PMID:22465603 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Nppb natriuretic peptide B decreases expression ISO fasudil results in decreased expression of NPPB mRNA CTD PMID:22465603 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Pkn2 protein kinase N2 decreases activity ISO fasudil results in decreased activity of PKN2 protein CTD PMID:10998351 NCBI chr 2:231,793,584...231,898,953
Ensembl chr 2:231,793,584...231,898,953 		JBrowse link
G Ppp1r12a protein phosphatase 1, regulatory subunit 12A multiple interactions EXP fasudil inhibits the reaction [Norepinephrine results in increased phosphorylation of PPP1R12A protein]; fasudil inhibits the reaction [Paraquat results in increased phosphorylation of PPP1R12A protein]; fasudil inhibits the reaction [Streptozocin results in increased expression of PPP1R12A protein modified form] CTD PMID:22429817 PMID:30088170 PMID:37963515 NCBI chr 7:43,482,808...43,593,689
Ensembl chr 7:43,482,803...43,593,425 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP
ISO		 fasudil inhibits the reaction [Methylmercury Compounds results in increased phosphorylation of RELA protein]; fasudil inhibits the reaction [Streptozocin results in increased expression of and affects the localization of RELA protein]
fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of RELA protein]		 CTD PMID:23376009 PMID:30462329 PMID:30924981 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rho rhodopsin multiple interactions ISO
EXP		 fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of RHO mRNA]; fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of RHO protein]
fasudil inhibits the reaction [Paraquat results in increased expression of RHO protein]
fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of RHO mRNA]; fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of RHO protein]; fasudil inhibits the reaction [Paraquat results in increased expression of RHO protein]		 CTD PMID:30088170 PMID:30924981 NCBI chr 4:148,975,597...148,988,693
Ensembl chr 4:148,980,611...148,985,773 		JBrowse link
G Rhoa ras homolog family member A decreases expression
multiple interactions		 ISO fasudil results in decreased expression of RHOA mRNA; fasudil results in decreased expression of RHOA protein
fasudil inhibits the reaction [Acetaminophen results in increased expression of RHOA protein]		 CTD PMID:26172442 PMID:34078832 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746 		JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 decreases expression
multiple interactions		 ISO
EXP		 fasudil results in decreased expression of ROCK1 mRNA; fasudil results in decreased expression of ROCK1 protein
fasudil inhibits the reaction [Acetaminophen results in increased expression of ROCK1 protein]; fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of ROCK1 mRNA]; fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of ROCK1 protein]
fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of ROCK1 mRNA]; fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of ROCK1 protein]; fasudil inhibits the reaction [Paraquat results in increased expression of ROCK1 protein]
fasudil affects the reaction [Daunorubicin affects the expression of ROCK1 mRNA]; fasudil inhibits the reaction [Paraquat results in increased expression of ROCK1 protein]; fasudil inhibits the reaction [Streptozocin results in increased activity of ROCK1 protein]; fasudil inhibits the reaction [Streptozocin results in increased expression of ROCK1 mRNA]		 CTD PMID:20037814 PMID:22429817 PMID:23376009 PMID:26172442 PMID:30088170 More... NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571 		JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 decreases activity
multiple interactions		 EXP
ISO		 fasudil results in decreased activity of ROCK2 protein
fasudil inhibits the reaction [Acetaminophen results in increased expression of ROCK2 protein]; fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of ROCK2 mRNA]; fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of ROCK2 protein]		 CTD PMID:10998351 PMID:30924981 PMID:34078832 NCBI chr 6:39,679,116...39,774,033
Ensembl chr 6:39,679,082...39,774,031 		JBrowse link
G Rps6ka1 ribosomal protein S6 kinase A1 decreases activity ISO fasudil results in decreased activity of RPS6KA1 protein CTD PMID:10998351 NCBI chr 5:146,079,018...146,118,272
Ensembl chr 5:146,079,021...146,118,272 		JBrowse link
G Rps6ka5 ribosomal protein S6 kinase A5 decreases activity ISO fasudil results in decreased activity of RPS6KA5 protein CTD PMID:10998351 NCBI chr 6:119,828,823...120,006,190
Ensembl chr 6:119,828,846...120,006,224 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases activity ISO fasudil results in decreased activity of RPS6KB1 protein CTD PMID:10998351 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions ISO 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with Ascorbic Acid] co-treated with fasudil] results in increased expression of RUNX2 mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with Ascorbic Acid] co-treated with fasudil] results in increased expression of RUNX2 protein]; [[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with Ascorbic Acid] co-treated with fasudil] results in increased expression of RUNX2 mRNA; [[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with Ascorbic Acid] co-treated with fasudil] results in increased expression of RUNX2 protein CTD PMID:31935364 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167 		JBrowse link
G Slc12a2 solute carrier family 12 member 2 increases expression ISO fasudil results in increased expression of SLC12A2 protein CTD PMID:21474433 NCBI chr18:51,348,282...51,416,448
Ensembl chr18:51,348,302...51,416,440 		JBrowse link
G Snca synuclein alpha multiple interactions EXP fasudil inhibits the reaction [propionic acid results in increased expression of SNCA mRNA] CTD PMID:32481507 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262 		JBrowse link
G Syp synaptophysin multiple interactions EXP fasudil inhibits the reaction [Rotenone results in decreased expression of SYP mRNA]; fasudil inhibits the reaction [Streptozocin results in decreased expression of SYP mRNA]; fasudil inhibits the reaction [Streptozocin results in decreased expression of SYP protein] CTD PMID:22062134 PMID:32481507 NCBI chr  X:14,849,444...14,864,553
Ensembl chr  X:14,849,444...14,864,745 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression
multiple interactions		 ISO
EXP		 fasudil results in decreased expression of TGFB1 protein
fasudil inhibits the reaction [Streptozocin results in increased expression of TGFB1 protein]		 CTD PMID:22465603 PMID:23376009 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP [[propionic acid co-treated with fasudil] affects the susceptibility to Rotenone] which results in increased expression of TH mRNA CTD PMID:32481507 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 affects expression ISO fasudil affects the expression of TIMP1 mRNA CTD PMID:22465603 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Tjp1 tight junction protein 1 multiple interactions EXP
ISO		 fasudil inhibits the reaction [Paraquat results in decreased expression of TJP1 protein] CTD PMID:30088170 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432 		JBrowse link
G Tnf tumor necrosis factor affects expression
multiple interactions		 ISO
EXP		 fasudil affects the expression of TNF mRNA
fasudil inhibits the reaction [Acetaminophen results in increased expression of TNF protein]; fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]
fasudil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]; fasudil inhibits the reaction [Paraquat results in increased secretion of TNF protein]
fasudil inhibits the reaction [Methylmercury Compounds results in increased expression of TNF protein]; fasudil inhibits the reaction [Paraquat results in increased expression of TNF protein]		 CTD PMID:26120273 PMID:30088170 PMID:30462329 PMID:30924981 PMID:34078832 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Trpc1 transient receptor potential cation channel, subfamily C, member 1 multiple interactions ISO fasudil inhibits the reaction [Oxygen deficiency results in increased expression of TRPC1 protein] CTD PMID:30831131 NCBI chr 8:96,263,322...96,314,220
Ensembl chr 8:96,263,329...96,314,276 		JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 multiple interactions ISO fasudil inhibits the reaction [Oxygen deficiency results in increased expression of TRPC6 protein] CTD PMID:30831131 NCBI chr 8:5,759,387...5,864,000
Ensembl chr 8:5,758,935...5,828,092 		JBrowse link
G Vegfa vascular endothelial growth factor A affects expression ISO fasudil affects the expression of VEGFA mRNA CTD PMID:26120273 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
ML-7 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle decreases expression
affects localization		 EXP
ISO		 ML 7 results in decreased expression of ACTA2
ML 7 affects the localization of ACTA2 protein		 CTD PMID:11591817 PMID:11868461 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO ML 7 results in decreased susceptibility to [quinocetone results in increased phosphorylation of AKT1 protein] CTD PMID:26446980 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [ML 7 co-treated with quinocetone] results in increased expression of BAX protein; ML 7 results in increased susceptibility to [quinocetone results in increased expression of BAX protein] CTD PMID:26446980 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcar1 BCAR1 scaffold protein, Cas family member decreases phosphorylation ISO ML 7 results in decreased phosphorylation of BCAR1 protein CTD PMID:18718759 NCBI chr19:39,679,215...39,713,907
Ensembl chr19:39,679,204...39,713,907 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO [ML 7 co-treated with quinocetone] results in decreased expression of BCL2 protein; ML 7 results in increased susceptibility to [quinocetone results in decreased expression of BCL2 protein] CTD PMID:26446980 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO ML 7 results in decreased expression of BIRC5 protein CTD PMID:18710790 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO [ML 7 co-treated with quinocetone] results in increased cleavage of CASP3 protein; [ML 7 results in decreased activity of MYLK protein] which results in increased activity of CASP3 protein; FADD protein affects the reaction [[ML 7 results in decreased activity of MYLK protein] which results in increased activity of CASP3 protein] CTD PMID:16723733 PMID:26446980 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO [ML 7 co-treated with quinocetone] results in increased cleavage of CASP8 protein; ML 7 results in increased susceptibility to [quinocetone results in increased cleavage of CASP8 protein] CTD PMID:26446980 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO [ML 7 co-treated with quinocetone] results in increased cleavage of CASP9 protein; ML 7 results in increased susceptibility to [quinocetone results in increased cleavage of CASP9 protein] CTD PMID:26446980 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccna2 cyclin A2 multiple interactions EXP ML 7 inhibits the reaction [EGF protein results in increased expression of CCNA2 protein] CTD PMID:16799973 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression		 EXP
ISO		 ML 7 inhibits the reaction [EGF protein results in increased expression of CCND1 mRNA]; ML 7 inhibits the reaction [EGF protein results in increased expression of CCND1 protein]
ML 7 results in decreased expression of CCND1 protein		 CTD PMID:16799973 PMID:18710790 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccne1 cyclin E1 multiple interactions EXP ML 7 inhibits the reaction [EGF protein results in increased expression of CCNE1 protein] CTD PMID:16799973 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Cdh1 cadherin 1 decreases activity
affects localization		 ISO ML 7 results in decreased activity of CDH1 protein
ML 7 affects the localization of CDH1 protein		 CTD PMID:16030252 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions EXP ML 7 inhibits the reaction [EGF protein results in increased expression of CDK1 protein] CTD PMID:16799973 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression ISO ML 7 results in decreased expression of CDKN1A protein CTD PMID:15252113 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO ML 7 results in increased expression of CDKN1B protein CTD PMID:15252113 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Col17a1 collagen type XVII alpha 1 chain affects localization ISO ML 7 affects the localization of COL17A1 protein CTD PMID:14691950 NCBI chr 1:246,530,589...246,577,559
Ensembl chr 1:246,531,367...246,577,632 		JBrowse link
G Csf2 colony stimulating factor 2 affects activity ISO ML 7 affects the activity of CSF2 protein CTD PMID:8471626 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199 		JBrowse link
G Ctnnb1 catenin beta 1 affects localization
decreases expression		 ISO ML 7 affects the localization of CTNNB1 protein
ML 7 results in decreased expression of CTNNB1 protein		 CTD PMID:18710790 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 multiple interactions ISO ML 7 inhibits the reaction [CXCL12 protein results in increased phosphorylation of MYL9 protein] CTD PMID:11751986 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168 		JBrowse link
G Dst dystonin affects localization ISO ML 7 affects the localization of DST protein CTD PMID:14691950 NCBI chr 9:36,135,657...36,529,617
Ensembl chr 9:36,135,284...36,529,615 		JBrowse link
G Egf epidermal growth factor multiple interactions EXP ML 7 inhibits the reaction [EGF protein affects the localization of MYL9 protein modified form]; ML 7 inhibits the reaction [EGF protein results in increased expression of CCNA2 protein]; ML 7 inhibits the reaction [EGF protein results in increased expression of CCND1 mRNA]; ML 7 inhibits the reaction [EGF protein results in increased expression of CCND1 protein]; ML 7 inhibits the reaction [EGF protein results in increased expression of CCNE1 protein]; ML 7 inhibits the reaction [EGF protein results in increased expression of CDK1 protein]; ML 7 inhibits the reaction [EGF protein results in increased expression of FOS protein]; ML 7 inhibits the reaction [EGF protein results in increased expression of JUN protein]; ML 7 inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of RPS6KB1 protein] CTD PMID:16799973 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G F2 coagulation factor II, thrombin multiple interactions
decreases activity
affects activity		 ISO
EXP		 ML 7 inhibits the reaction [F2 protein results in increased phosphorylation of MYL9 protein]
[ML 7 results in decreased activity of MYLK protein] which results in decreased activity of F2 protein
ML 7 affects the activity of F2 protein		 CTD PMID:1643115 PMID:14557824 PMID:15284075 PMID:16675616 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486 		JBrowse link
G Fadd Fas associated via death domain multiple interactions ISO FADD protein affects the reaction [[ML 7 results in decreased activity of MYLK protein] which results in increased activity of CASP3 protein] CTD PMID:16723733 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP ML 7 inhibits the reaction [EGF protein results in increased expression of FOS protein] CTD PMID:16799973 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Hexb hexosaminidase subunit beta multiple interactions EXP ML 7 inhibits the reaction [Ionomycin results in increased secretion of HEXB protein] CTD PMID:14499669 NCBI chr 2:28,483,997...28,504,165
Ensembl chr 2:28,484,012...28,504,223 		JBrowse link
G Il17a interleukin 17A multiple interactions ISO ML 7 inhibits the reaction [IL17A protein results in increased phosphorylation of MYL9 protein] CTD PMID:19940258 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889 		JBrowse link
G Itga3 integrin subunit alpha 3 multiple interactions ISO ML 7 affects the localization of [ITGA3 protein binds to ITGB1 protein] CTD PMID:14691950 NCBI chr10:79,990,160...80,022,206
Ensembl chr10:79,990,161...80,022,118 		JBrowse link
G Itga6 integrin subunit alpha 6 multiple interactions ISO ML 7 affects the localization of [ITGA6 protein binds to ITGB4 protein] CTD PMID:14691950 NCBI chr 3:56,604,512...56,689,428
Ensembl chr 3:56,617,268...56,689,428 		JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO ML 7 inhibits the reaction [Lipopolysaccharides results in increased expression of ITGAM protein] CTD PMID:19374788 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Itgb1 integrin subunit beta 1 multiple interactions
decreases activity		 ISO ML 7 affects the localization of [ITGA3 protein binds to ITGB1 protein]
ML 7 results in decreased activity of ITGB1 protein		 CTD PMID:14691950 PMID:16723733 NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195 		JBrowse link
G Itgb4 integrin subunit beta 4 multiple interactions ISO ML 7 affects the localization of [ITGA6 protein binds to ITGB4 protein] CTD PMID:14691950 NCBI chr10:101,206,657...101,243,012
Ensembl chr10:101,206,665...101,243,012 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP ML 7 inhibits the reaction [EGF protein results in increased expression of JUN protein] CTD PMID:16799973 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Lama3 laminin subunit alpha 3 affects localization ISO ML 7 affects the localization of LAMA3 protein CTD PMID:14691950 NCBI chr18:3,523,168...3,751,722
Ensembl chr18:3,523,133...3,751,353 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation
multiple interactions		 ISO ML 7 results in decreased phosphorylation of MAPK1 protein
[ML 7 co-treated with quinocetone] results in increased phosphorylation of MAPK1 protein; ML 7 results in increased susceptibility to [quinocetone results in increased phosphorylation of MAPK1 protein]		 CTD PMID:18710790 PMID:26446980 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO [ML 7 co-treated with quinocetone] results in increased phosphorylation of MAPK14 protein; ML 7 results in increased susceptibility to [quinocetone results in increased phosphorylation of MAPK14 protein] CTD PMID:26446980 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO ML 7 results in decreased phosphorylation of MAPK3 protein CTD PMID:18710790 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO [ML 7 co-treated with quinocetone] results in increased phosphorylation of MAPK8 protein CTD PMID:26446980 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mpo myeloperoxidase multiple interactions
decreases activity		 EXP
ISO		 ML 7 inhibits the reaction [Lipopolysaccharides results in increased activity of MPO protein]
ML 7 results in decreased activity of MPO protein		 CTD PMID:15863634 PMID:19374788 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO ML 7 results in decreased expression of MYC protein CTD PMID:18710790 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Myh2 myosin heavy chain 2 affects localization
decreases activity		 ISO ML 7 affects the localization of MYH2 protein
ML 7 results in decreased activity of MYH2 protein		 CTD PMID:16030252 NCBI chr10:51,856,738...51,883,236
Ensembl chr10:51,856,738...51,883,236 		JBrowse link
G Myl7 myosin light chain 7 multiple interactions
decreases phosphorylation		 ISO ML 7 inhibits the reaction [Phenylephrine results in increased phosphorylation of MYL7 protein]
ML 7 results in decreased phosphorylation of MYL7 protein		 CTD PMID:15621049 NCBI chr14:80,780,684...80,783,259
Ensembl chr14:80,779,776...80,783,244 		JBrowse link
G Myl9 myosin light chain 9 multiple interactions
decreases expression
decreases phosphorylation		 ISO
EXP		 [ML 7 results in decreased activity of MYLK protein] which results in decreased phosphorylation of MYL9 protein; ML 7 inhibits the reaction [CXCL12 protein results in increased phosphorylation of MYL9 protein]; ML 7 inhibits the reaction [F2 protein results in increased phosphorylation of MYL9 protein]; ML 7 inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MYL9 protein]
ML 7 results in decreased expression of MYL9 protein modified form
ML 7 results in decreased phosphorylation of MYL9 protein
[[ML 7 results in decreased activity of MYLK protein] which results in decreased phosphorylation of MYL9 protein] which results in increased secretion of REN protein; [ML 7 results in decreased activity of MYLK protein] which results in decreased phosphorylation of MYL9 protein; ML 7 inhibits the reaction [Deamino Arginine Vasopressin results in increased phosphorylation of MYL9 protein]; ML 7 inhibits the reaction [EGF protein affects the localization of MYL9 protein modified form]; ML 7 inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MYL9 protein]
ML 7 inhibits the reaction [IL17A protein results in increased phosphorylation of MYL9 protein]		 CTD PMID:1643115 PMID:7503253 PMID:9618396 PMID:11751986 PMID:12745062 More... NCBI chr 3:145,281,943...145,288,333
Ensembl chr 3:145,281,937...145,288,333 		JBrowse link
G Mylk myosin light chain kinase multiple interactions
decreases activity		 ISO
EXP		 [ML 7 results in decreased activity of MYLK protein] which results in decreased phosphorylation of MYL9 protein; [ML 7 results in decreased activity of MYLK protein] which results in increased activity of CASP3 protein; FADD protein affects the reaction [[ML 7 results in decreased activity of MYLK protein] which results in increased activity of CASP3 protein]; ML 7 inhibits the reaction [Calcium deficiency results in increased activity of MYLK protein]; ML 7 inhibits the reaction [Ethanol results in increased activity of MYLK protein]
[ML 7 results in decreased activity of MYLK protein] which results in decreased activity of F2 protein; ML 7 results in decreased activity of MYLK protein
ML 7 inhibits the reaction [Lipopolysaccharides results in increased expression of MYLK mRNA]; ML 7 inhibits the reaction [Lipopolysaccharides results in increased expression of MYLK protein]; ML 7 inhibits the reaction [MYLK protein results in increased uptake of Glucose]
[[ML 7 results in decreased activity of MYLK protein] which results in decreased phosphorylation of MYL9 protein] which results in increased secretion of REN protein; [ML 7 results in decreased activity of MYLK protein] which results in decreased phosphorylation of MYL9 protein		 CTD PMID:1643115 PMID:9618396 PMID:10198341 PMID:10733514 PMID:11054866 More... NCBI chr11:65,783,008...66,030,239
Ensembl chr11:65,783,008...66,030,261 		JBrowse link
G Myod1 myogenic differentiation 1 decreases expression ISO ML 7 results in decreased expression of MYOD1 protein CTD PMID:15252113 NCBI chr 1:96,884,864...96,887,574
Ensembl chr 1:96,884,948...96,887,554 		JBrowse link
G Myog myogenin decreases expression ISO ML 7 results in decreased expression of MYOG protein CTD PMID:15252113 NCBI chr13:45,745,455...45,748,044
Ensembl chr13:45,745,436...45,748,039 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions ISO ML 7 inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of NCF1 protein]; ML 7 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of NCF1 protein] CTD PMID:7575484 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646 		JBrowse link
G Prkcb protein kinase C, beta decreases expression EXP ML 7 results in decreased expression of PRKCB protein CTD PMID:17272349 NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536 		JBrowse link
G Ptk2 protein tyrosine kinase 2 decreases phosphorylation ISO ML 7 results in decreased phosphorylation of PTK2 protein CTD PMID:18718759 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783 		JBrowse link
G Rac1 Rac family small GTPase 1 decreases activity
increases activity		 EXP ML 7 results in decreased activity of RAC1 protein
ML 7 results in increased activity of RAC1 protein		 CTD PMID:12105187 PMID:12745062 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251 		JBrowse link
G Ren renin multiple interactions
increases secretion		 EXP [[ML 7 results in decreased activity of MYLK protein] which results in decreased phosphorylation of MYL9 protein] which results in increased secretion of REN protein; calyculin A inhibits the reaction [ML 7 results in increased secretion of REN protein]; ML 7 inhibits the reaction [Calcium results in decreased secretion of REN protein] CTD PMID:9618396 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
G Rps6ka5 ribosomal protein S6 kinase A5 decreases activity ISO ML 7 results in decreased activity of RPS6KA5 protein CTD PMID:12534346 NCBI chr 6:119,828,823...120,006,190
Ensembl chr 6:119,828,846...120,006,224 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions EXP
ISO		 ML 7 inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]
ML 7 results in decreased susceptibility to [quinocetone results in increased phosphorylation of RPS6KB1 protein]		 CTD PMID:16799973 PMID:26446980 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Slc2a2 solute carrier family 2 member 2 multiple interactions
decreases activity
decreases expression		 EXP ML 7 inhibits the reaction [SLC2A2 protein results in increased uptake of Glucose]
ML 7 results in decreased activity of SLC2A2 protein
ML 7 results in decreased expression of SLC2A2 protein		 CTD PMID:17272349 NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933 		JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO ML 7 inhibits the reaction [Oxygen deficiency affects the localization of TJP1 protein]
ML 7 inhibits the reaction [Luteolin inhibits the reaction [decabromobiphenyl ether results in decreased expression of TJP1 protein]]		 CTD PMID:20164382 PMID:33675858 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432 		JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 decreases activity ISO ML 7 results in decreased activity of TRPC6 protein CTD PMID:17603544 NCBI chr 8:5,759,387...5,864,000
Ensembl chr 8:5,758,935...5,828,092 		JBrowse link
G Trpc7 transient receptor potential cation channel, subfamily C, member 7 increases activity ISO ML 7 results in increased activity of TRPC7 protein CTD PMID:17603544 NCBI chr17:7,708,911...7,833,435
Ensembl chr17:7,709,583...7,833,435 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    chemical entity 19878
      atom 19878
        nonmetal atom 19800
          nitrogen atom 18979
            nitrogen molecular entity 18979
              amide 17776
                N-acyldiazepane 102
                  N-carbonyldiazepane + 0
                  N-sulfonyldiazepane + 102
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            organic molecule 19706
                              organic cyclic compound 19495
                                organic heterocyclic compound 18874
                                  organic heteromonocyclic compound 17795
                                    diazepane 104
                                      N-acyldiazepane 102
                                        N-carbonyldiazepane + 0
                                        N-sulfonyldiazepane + 102
paths to the root