imidazopyridine - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	imidazopyridine	go back to main search page
Accession:	CHEBI:46908	browse the term
Synonyms:	related_synonym:	imidazopyridines

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Rat (712) Mouse (706) Human (721) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (2) Green Monkey (0) Naked Mole-rat (0) All
Genes (712)

2-Amino-1,6-dimethylfuro[3,2-e]imidazo[4,5-b]pyridine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

estrogen receptor 1

multiple interactions

2-amino-(1,6-dimethylfuro(3,2-e)imidazo(4,5-b))pyridine inhibits the reaction [Estradiol results in increased activity of ESR1 protein]

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensin I converting enzyme

decreases expression

Fadrozole results in decreased expression of ACE protein

NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131

G

angiotensin converting enzyme 2

increases expression

Fadrozole results in increased expression of ACE2 protein

NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977

G

angiotensin II receptor, type 1a

decreases expression

Fadrozole results in decreased expression of AGTR1 protein

NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946

G

angiotensin II receptor, type 2

increases expression

Fadrozole results in increased expression of AGTR2 protein

NCBI chr X:112,119,876...112,124,060
Ensembl chr X:112,120,228...112,124,057

G

cytochrome P450, family 11, subfamily b, polypeptide 2

decreases activity

Fadrozole results in decreased activity of CYP11B1 protein

PMID:15743198 PMID:15771425 PMID:15985365 PMID:21341743

NCBI chr 7:106,838,590...106,845,004
Ensembl chr 7:106,838,590...106,845,004

G

cytochrome P450, family 11, subfamily b, polypeptide 3

decreases activity

Fadrozole results in decreased activity of CYP11B2 protein

PMID:15743198 PMID:15771425 PMID:15985365 PMID:21341743

NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048

G

cytochrome P450, family 17, subfamily a, polypeptide 1

decreases activity

Fadrozole results in decreased activity of CYP17A1 protein

PMID:15743198 PMID:15771425

NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573

G

cytochrome P450, family 19, subfamily a, polypeptide 1

decreases activity
multiple interactions
increases activity

Fadrozole results in decreased activity of CYP19A1 protein
Genistein inhibits the reaction [Fadrozole results in increased activity of CYP19A1 protein]

PMID:15743198 PMID:15771425 PMID:21341743 PMID:21854827

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

cytochrome P450, family 51

decreases activity

Fadrozole results in decreased activity of CYP51A1 protein

NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410
Ensembl chr 6:30,036,865...30,055,410

G

estrogen receptor 1

multiple interactions

Fadrozole binds to and results in decreased activity of ESR1 protein

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions

Fadrozole binds to and results in increased activity of NR1I2 protein

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

trefoil factor 1

multiple interactions

[Dexamethasone co-treated with Fadrozole] inhibits the reaction [Testosterone results in increased expression of TFF1 mRNA]; Fadrozole inhibits the reaction [bisphenol A results in increased expression of TFF1 mRNA]; Fadrozole inhibits the reaction [Testosterone results in increased expression of TFF1 mRNA]

NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597

ageladine A

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

dual specificity tyrosine phosphorylation regulated kinase 1A

decreases activity
multiple interactions

Ageladine A results in decreased activity of DYRK1A protein
Ageladine A analog binds to and results in decreased activity of DYRK1A protein

NCBI chr11:33,890,706...34,009,420
Ensembl chr11:33,890,490...34,009,420

G

matrix metallopeptidase 14

decreases activity

Ageladine A results in decreased activity of MMP14 protein

NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864

G

matrix metallopeptidase 2

decreases activity

Ageladine A results in decreased activity of MMP2 protein

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

Pim-1 proto-oncogene, serine/threonine kinase

decreases activity

Ageladine A results in decreased activity of PIM1 protein

NCBI chr20:7,554,921...7,559,174
Ensembl chr20:7,554,921...7,559,174

Glu-P-1

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aryl hydrocarbon receptor

increases expression

2-amino-6-methyldipyrido(1,2-a-3',2'-d)imidazole results in increased expression of AHR protein

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression

2-amino-6-methyldipyrido(1,2-a-3',2'-d)imidazole results in increased expression of CYP1A1 mRNA

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

affects metabolic processing
multiple interactions
increases hydroxylation

CYP1A2 protein affects the metabolism of 2-amino-6-methyldipyrido(1,2-a-3',2'-d)imidazole
CYP1A2 protein results in increased metabolism of and results in increased susceptibility to 2-amino-6-methyldipyrido(1,2-a-3',2'-d)imidazole
CYP1A2 protein results in increased hydroxylation of 2-amino-6-methyldipyrido(1,2-a-3',2'-d)imidazole

PMID:2655891 PMID:14725854 PMID:28160022

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

H2A.X variant histone

increases expression

2-amino-6-methyldipyrido(1,2-a-3',2'-d)imidazole results in increased expression of H2AX protein modified form

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239

G

N-acetyltransferase 2

multiple interactions

NAT2 protein results in increased metabolism of and results in increased susceptibility to 2-amino-6-methyldipyrido(1,2-a-3',2'-d)imidazole

NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520

G

solute carrier family 22 member 2

multiple interactions
decreases activity

2-amino-6-methyldipyrido(1,2-a-3',2'-d)imidazole inhibits the reaction [SLC22A2 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]
2-amino-6-methyldipyrido(1,2-a-3',2'-d)imidazole results in decreased activity of SLC22A2 protein

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

solute carrier family 22 member 3

multiple interactions
decreases activity

2-amino-6-methyldipyrido(1,2-a-3',2'-d)imidazole inhibits the reaction [SLC22A3 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]
2-amino-6-methyldipyrido(1,2-a-3',2'-d)imidazole results in decreased activity of SLC22A3 protein

NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612

G

sulfotransferase family 1A member 1

multiple interactions

SULT1A1 protein results in increased metabolism of and results in increased susceptibility to 2-amino-6-methyldipyrido(1,2-a-3',2'-d)imidazole

NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562

Glu-P-2

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aryl hydrocarbon receptor

increases expression

Glu-P-2 results in increased expression of AHR protein

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

cytochrome P450, family 1, subfamily a, polypeptide 2

affects metabolic processing
multiple interactions
increases expression

CYP1A2 protein affects the metabolism of Glu-P-2
CYP1A2 protein results in increased metabolism of and results in increased susceptibility to Glu-P-2
Glu-P-2 results in increased expression of CYP1A2 mRNA

PMID:2655891 PMID:27644595 PMID:28160022

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

H2A.X variant histone

increases expression

Glu-P-2 results in increased expression of H2AX protein modified form

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239

G

N-acetyltransferase 2

multiple interactions

NAT2 protein results in increased metabolism of and results in increased susceptibility to Glu-P-2

NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520

G

solute carrier family 22 member 2

decreases activity
multiple interactions

Glu-P-2 results in decreased activity of SLC22A2 protein
Glu-P-2 inhibits the reaction [SLC22A2 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

solute carrier family 22 member 3

multiple interactions
decreases activity

Glu-P-2 inhibits the reaction [SLC22A3 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]
Glu-P-2 results in decreased activity of SLC22A3 protein

NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612

G

sulfotransferase family 1A member 1

multiple interactions

SULT1A1 protein results in increased metabolism of and results in increased susceptibility to Glu-P-2

NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562

GSK690693

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

multiple interactions
increases phosphorylation
decreases phosphorylation

GSK690693 inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of AKT1 protein]; GSK690693 promotes the reaction [1,4-naphthoquinone analog results in decreased phosphorylation of AKT1 protein]
GSK690693 results in increased phosphorylation of AKT1 protein
GSK690693 results in decreased phosphorylation of AKT1 protein

PMID:30871965 PMID:31445927 PMID:31962201 PMID:34784199 PMID:35259468

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

Bcl-2 binding component 3

increases expression

GSK690693 results in increased expression of BBC3 protein

NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509

G

BCL2, apoptosis regulator

multiple interactions

GSK690693 promotes the reaction [1,4-naphthoquinone analog results in decreased expression of BCL2 protein]

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

caspase 3

multiple interactions

GSK690693 promotes the reaction [1,4-naphthoquinone analog results in increased cleavage of CASP3 protein]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

catenin beta 1

decreases phosphorylation

GSK690693 results in decreased phosphorylation of CTNNB1 protein

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

eukaryotic translation initiation factor 4E binding protein 1

decreases phosphorylation
multiple interactions

GSK690693 results in decreased phosphorylation of EIF4EBP1 protein
[sunitinib co-treated with GSK690693] results in decreased phosphorylation of EIF4EBP1 protein

NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984

G

Fas cell surface death receptor

affects response to substance

GSK690693 affects the susceptibility to FAS protein

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

forkhead box O3

decreases phosphorylation

GSK690693 results in decreased phosphorylation of FOXO3 protein

NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561

G

glycogen synthase kinase 3 beta

decreases phosphorylation
increases expression

GSK690693 results in decreased phosphorylation of GSK3B protein
GSK690693 results in increased expression of GSK3B protein

PMID:31962201 PMID:35639300

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

H2A.X variant histone

multiple interactions

GSK690693 inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of H2AX protein]

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239

G

poly (ADP-ribose) polymerase 1

multiple interactions

GSK690693 promotes the reaction [1,4-naphthoquinone analog results in increased cleavage of PARP1 protein]

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

serine and arginine rich splicing factor 4

multiple interactions

[SRPIN340 co-treated with GSK690693] results in decreased phosphorylation of SRSF4 protein

NCBI chr 5:144,060,981...144,090,798
Ensembl chr 5:144,061,463...144,089,229

G

serine and arginine rich splicing factor 5

multiple interactions

[SRPIN340 co-treated with GSK690693] results in decreased phosphorylation of SRSF5 protein

NCBI chr 6:100,605,165...100,610,192
Ensembl chr 6:100,605,456...100,610,177

G

serine and arginine rich splicing factor 6

multiple interactions

[SRPIN340 co-treated with GSK690693] results in decreased phosphorylation of SRSF6 protein

NCBI chr 3:151,589,546...151,594,869
Ensembl chr 3:151,589,535...151,594,860

G

signal transducer and activator of transcription 3

multiple interactions

GSK690693 promotes the reaction [1,4-naphthoquinone analog results in decreased phosphorylation of STAT3 protein]

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

tumor necrosis factor

increases response to substance

GSK690693 results in increased susceptibility to TNF protein

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TSC complex subunit 2

multiple interactions
decreases phosphorylation

[sunitinib co-treated with GSK690693] results in decreased phosphorylation of TSC2 protein
GSK690693 results in decreased phosphorylation of TSC2 protein

NCBI chr10:13,621,135...13,655,773
Ensembl chr10:13,621,136...13,655,951

N-hydroxy-PhIP

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

multiple interactions

[ABCB1A protein affects the metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased abundance of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP-binding cassette, sub-family B member 1B

multiple interactions

[ABCB1B protein affects the metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased abundance of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine

NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199

G

ATP binding cassette subfamily C member 2

multiple interactions

[ABCC2 protein affects the metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased abundance of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily C member 3

multiple interactions

[ABCC3 protein affects the metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased abundance of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine

NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595

G

ATP binding cassette subfamily G member 2

affects transport
multiple interactions

ABCG2 protein affects the transport of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine
[ABCG2 protein affects the metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased abundance of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine

PMID:18322075 PMID:30701287

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions

[CYP1A1 protein results in increased hydroxylation of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased chemical synthesis of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine; [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] which results in increased chemical synthesis of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine
[[CYP1A2 protein co-treated with CYP1A1 protein] results in increased hydroxylation of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased chemical synthesis of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine; [CYP1A1 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased chemical synthesis of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine

PMID:16167840 PMID:17052995 PMID:17279779

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions

[[CYP1A2 protein co-treated with CYP1A1 protein] results in increased hydroxylation of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased chemical synthesis of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine; [CYP1A2 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased chemical synthesis of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine; [CYP1A2 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased chemical synthesis of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine metabolite
[CYP1A2 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased abundance of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine

PMID:1943715 PMID:16167840 PMID:17279779 PMID:20192249

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

multiple interactions

[CYP1B1 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased chemical synthesis of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 2, subfamily C, polypeptide 6

multiple interactions

[CYP2C19 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased chemical synthesis of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

estrogen receptor 1

multiple interactions
decreases activity

2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [Estradiol results in increased activity of ESR1 protein]
2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased activity of ESR1 protein

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

glutathione S-transferase alpha 1

increases expression

2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of GSTA1 protein

NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121

G

glutathione S-transferase alpha 3

increases expression

2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of GSTA3 protein

NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240

G

glutathione S-transferase alpha 4

increases expression

2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of GSTA4 protein

NCBI chr 8:79,066,967...79,084,193
Ensembl chr 8:79,066,934...79,084,182

G

glutathione S-transferase mu 1

increases expression

2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of GSTM1 protein

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

glutathione S-transferase pi 1

multiple interactions
increases expression
decreases response to substance

[GSTP1 protein co-treated with Glutathione] inhibits the reaction [[Adenosine Triphosphate results in increased metabolism of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased abundance of 2-amino-1-methyl-6-phenolimidazo(4,5-b)pyridine-DNA adduct]; [GSTP1 protein co-treated with Glutathione] inhibits the reaction [Adenosine Triphosphate results in increased activity of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine]
2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of GSTP1 protein
GSTP1 protein results in decreased susceptibility to 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine

PMID:11196146 PMID:17122891

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

N-acetyltransferase 1

multiple interactions
increases metabolic processing

NAT1 protein affects the acetylation of and affects the activity of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine
NAT1 protein results in increased metabolism of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine

PMID:11505221 PMID:29596660

NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520

G

N-acetyltransferase 2

multiple interactions
increases metabolic processing
increases acetylation

4-biphenylamine inhibits the reaction [NAT2 protein results in increased acetylation of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine]
NAT2 protein results in increased metabolism of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine

PMID:12222688 PMID:18842621 PMID:29596660

NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520

G

protein disulfide isomerase family A, member 3

affects expression
multiple interactions

2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine affects the expression of PDIA3 protein
[2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dihydrotestosterone] affects the expression of PDIA3 protein

NCBI chr 3:108,388,189...108,412,013
Ensembl chr 3:108,388,245...108,413,236

G

RAB7A, member RAS oncogene family

affects expression
multiple interactions

2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine affects the expression of RAB7A protein
[2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dihydrotestosterone] affects the expression of RAB7A protein

NCBI chr 4:120,461,966...120,510,756
Ensembl chr 4:120,461,963...120,506,889

G

ribosomal protein S7

multiple interactions
affects expression

[2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dihydrotestosterone] affects the expression of RPS7 protein
2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine affects the expression of RPS7 protein

NCBI chr 6:45,266,200...45,271,064
Ensembl chr 6:45,223,980...45,271,145
Ensembl chr 5:45,223,980...45,271,145

G

secretion associated, Ras related GTPase 1A

affects expression
multiple interactions

2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine affects the expression of SAR1A protein
[2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dihydrotestosterone] affects the expression of SAR1A protein

NCBI chr20:29,623,529...29,635,935
Ensembl chr20:29,623,553...29,635,935

G

sulfotransferase family 1A member 1

multiple interactions
increases metabolic processing

SULT1A1 protein results in increased metabolism of and results in increased activity of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine
SULT1A1 protein results in increased metabolism of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine

PMID:12067565 PMID:29596660

NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562

G

tumor protein p53

increases mutagenesis

2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased mutagenesis of TP53 protein

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

UDP glucuronosyltransferase family 1 member A1

multiple interactions
affects metabolic processing
increases metabolic processing
increases glucuronidation

UGT1A1 promoter polymorphism affects the reaction [2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine binds to Glucuronides]; UGT1A1 protein promotes the reaction [2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine binds to Glucuronides]; UGT1A1 protein results in increased glucuronidation of and results in decreased activity of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine
UGT1A1 promoter polymorphism affects the metabolism of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine
UGT1A1 protein results in increased metabolism of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine
UGT1A1 protein results in increased glucuronidation of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine

PMID:11442279 PMID:15310245 PMID:15769885 PMID:15986396

NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase 1 family, polypeptide A2

increases glucuronidation

UGT1A3 protein results in increased glucuronidation of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine

NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A5

increases metabolic processing
multiple interactions
increases glucuronidation

UGT1A4 protein results in increased metabolism of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine
UGT1A4 protein promotes the reaction [2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine binds to Glucuronides]
UGT1A4 protein results in increased glucuronidation of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine

PMID:15310245 PMID:15986396

NCBI chr 9:88,762,250...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A9

multiple interactions
increases metabolic processing
increases glucuronidation

UGT1A9 protein promotes the reaction [2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine binds to Glucuronides]
UGT1A9 protein results in increased metabolism of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine
UGT1A9 protein results in increased glucuronidation of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine

PMID:11375903 PMID:15310245 PMID:15986396

NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465

PD123319

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensin converting enzyme 2

multiple interactions

PD 123319 inhibits the reaction [diminazene aceturate results in increased expression of ACE2 protein]

NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977

G

angiotensinogen

multiple interactions
decreases activity
decreases response to substance

[olmesartan co-treated with PD 123319] inhibits the reaction [AGT protein modified form results in increased abundance of Fatty Acids, Nonesterified]; [olmesartan co-treated with PD 123319] inhibits the reaction [AGT protein modified form results in increased secretion of and results in increased abundance of Triglycerides]; PD 123319 inhibits the reaction [AGT protein results in increased expression of MDM2 mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of MDM2 protein]
PD 123319 inhibits the reaction [AGT protein results in increased expression of UBE2V2 mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of UBE2V2 protein]; PD 123319 inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]; PD 123319 inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of CYBB mRNA]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of CYBB protein]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX1 mRNA]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX1 protein]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX4 mRNA]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTRAP mRNA]]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTRAP protein]]]; PD 123319 inhibits the reaction [CGP 42112A promotes the reaction [[AGT protein co-treated with Rotenone] results in increased expression of AGTR2 protein]]; PD 123319 inhibits the reaction [CGP 42112A promotes the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTR2 mRNA]]]
PD 123319 affects the reaction [AGT protein promotes the reaction [PTPN6 protein binds to MTUS1 protein]]; PD 123319 inhibits the reaction [AGT protein results in increased abundance of Nitric Oxide]; PD 123319 inhibits the reaction [AGT protein results in increased expression of ANGPT1 mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of ANGPT2 mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of EDN1 protein]; PD 123319 inhibits the reaction [AGT protein results in increased expression of KDR mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of MAP2 protein]; PD 123319 inhibits the reaction [AGT protein results in increased expression of SPP1 mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of SPP1 protein]; PD 123319 inhibits the reaction [AGT protein results in increased expression of TEK mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of TUBB3 protein]; PD 123319 inhibits the reaction [AGT protein results in increased expression of UBE2V2 protein]; PD 123319 inhibits the reaction [AGT protein results in increased expression of VEGFA mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of VEGFA protein]; PD 123319 promotes the reaction [AGT protein results in increased abundance of Prostaglandins E]
PD 123319 results in decreased activity of AGT protein modified form
PD 123319 results in decreased susceptibility to AGT protein

PMID:9176287 PMID:9519251 PMID:11115077 PMID:14597853 PMID:14638905 More...

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

angiotensin II receptor, type 2

multiple interactions
decreases activity
increases expression
decreases expression

[PD 123319 binds to and results in decreased activity of AGTR2 protein] inhibits the reaction [candesartan results in increased expression of NOS3 protein]; PD 123319 binds to and results in decreased activity of AGTR2 protein
PD 123319 inhibits the reaction [CGP 42112A promotes the reaction [[AGT protein co-treated with Rotenone] results in increased expression of AGTR2 protein]]; PD 123319 inhibits the reaction [CGP 42112A promotes the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTR2 mRNA]]]
PD 123319 results in decreased activity of AGTR2 protein
PD 123319 results in increased expression of AGTR2 mRNA; PD 123319 results in increased expression of AGTR2 protein
[PD 123319 binds to and results in decreased activity of AGTR2 protein] which affects the susceptibility to Phenylephrine; [PD 123319 results in decreased activity of AGTR2 protein] inhibits the reaction [Valsartan results in increased abundance of Cyclic GMP]; [PD 123319 results in decreased activity of AGTR2 protein] which results in decreased susceptibility to Estradiol; [PD 123319 results in decreased activity of AGTR2 protein] which results in decreased susceptibility to Valsartan; PD 123319 binds to and results in decreased activity of AGTR2 protein
PD 123319 results in decreased expression of AGTR2 mRNA

PMID:9336375 PMID:9740612 PMID:11509473 PMID:11893553 PMID:15807884 More...

NCBI chr X:112,119,876...112,124,060
Ensembl chr X:112,120,228...112,124,057

G

angiotensin II receptor-associated protein

multiple interactions

PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTRAP mRNA]]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTRAP protein]]]

NCBI chr 5:158,507,427...158,519,036
Ensembl chr 5:158,508,749...158,519,036

G

angiopoietin 1

multiple interactions

PD 123319 inhibits the reaction [AGT protein results in increased expression of ANGPT1 mRNA]

NCBI chr 7:73,528,345...73,783,953
Ensembl chr 7:73,531,486...73,784,067

G

angiopoietin 2

multiple interactions

PD 123319 inhibits the reaction [AGT protein results in increased expression of ANGPT2 mRNA]

NCBI chr16:71,088,364...71,138,805
Ensembl chr16:71,088,364...71,138,804

G

bradykinin receptor B2

multiple interactions

PD 123319 affects the reaction [BDKRB2 affects the abundance of 6-Ketoprostaglandin F1 alpha]

NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497

G

C-C motif chemokine ligand 2

multiple interactions

PD 123319 inhibits the reaction [Streptozocin results in increased expression of CCL2 mRNA]

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 5

multiple interactions

PD 123319 inhibits the reaction [Ethylene Glycol results in increased expression of CCL5 protein]

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

cytochrome b-245 beta chain

multiple interactions

PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of CYBB mRNA]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of CYBB protein]]

NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586

G

endothelin 1

multiple interactions

PD 123319 inhibits the reaction [AGT protein results in increased expression of EDN1 protein]

NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885

G

Janus kinase 2

multiple interactions

PD123319 co-treated with losartan inhibits the reaction [Angiotensin II increases phosphorylation of JAK2 protein in liver]

RGD

NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189

G

kinase insert domain receptor

multiple interactions

PD 123319 inhibits the reaction [AGT protein results in increased expression of KDR mRNA]

NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018

G

kininogen 1

multiple interactions

PD 123319 affects the reaction [KNG1 affects the abundance of Nitric Oxide]
PD 123319 inhibits the reaction [benazepril promotes the reaction [Valsartan results in increased expression of KNG1 protein modified form]]; PD 123319 inhibits the reaction [Valsartan promotes the reaction [benazepril results in increased expression of KNG1 protein modified form]]

PMID:11509473 PMID:16514058

NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555

G

microtubule-associated protein 2

multiple interactions

PD 123319 inhibits the reaction [AGT protein results in increased expression of MAP2 protein]

NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809

G

mitogen activated protein kinase 1

multiple interactions

PD 123319 inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

PD 123319 inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

MDM2 proto-oncogene

multiple interactions

PD 123319 inhibits the reaction [AGT protein results in increased expression of MDM2 mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of MDM2 protein]

NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915

G

microtubule associated scaffold protein 1

multiple interactions

PD 123319 affects the reaction [AGT protein promotes the reaction [PTPN6 protein binds to MTUS1 protein]]

NCBI chr16:51,202,497...51,347,794
Ensembl chr16:51,253,562...51,347,793

G

nuclear factor kappa B subunit 1

multiple interactions

PD 123319 inhibits the reaction [Ethylene Glycol results in increased expression of NFKB1 protein]

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

nitric oxide synthase 3

multiple interactions

[PD 123319 binds to and results in decreased activity of AGTR2 protein] inhibits the reaction [candesartan results in increased expression of NOS3 protein]

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

NADPH oxidase 1

multiple interactions

PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX1 mRNA]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX1 protein]]

NCBI chr X:97,279,058...97,332,291
Ensembl chr X:97,279,056...97,302,236

G

NADPH oxidase 4

multiple interactions

PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX4 mRNA]]

NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406

G

protein kinase C, epsilon

increases expression

PD 123319 results in increased expression of PRKCE protein

NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719

G

protein tyrosine phosphatase, non-receptor type 6

multiple interactions

PD 123319 affects the reaction [AGT protein promotes the reaction [PTPN6 protein binds to MTUS1 protein]]

NCBI chr 4:157,526,034...157,550,783
Ensembl chr 4:157,526,035...157,550,984

G

secreted phosphoprotein 1

multiple interactions

PD 123319 inhibits the reaction [AGT protein results in increased expression of SPP1 mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of SPP1 protein]

NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162

G

TEK receptor tyrosine kinase

multiple interactions

PD 123319 inhibits the reaction [AGT protein results in increased expression of TEK mRNA]

NCBI chr 5:109,607,077...109,733,805
Ensembl chr 5:109,607,077...109,733,804

G

tubulin, beta 3 class III

multiple interactions

PD 123319 inhibits the reaction [AGT protein results in increased expression of TUBB3 protein]

NCBI chr19:51,457,187...51,466,243
Ensembl chr19:51,457,184...51,466,243

G

ubiquitin conjugating enzyme E2 V2

multiple interactions

PD 123319 inhibits the reaction [AGT protein results in increased expression of UBE2V2 mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of UBE2V2 protein]

PMID:16769992 PMID:17068200

NCBI chr11:85,304,528...85,338,430
Ensembl chr11:85,304,526...85,336,369

G

vascular endothelial growth factor A

multiple interactions

PD 123319 inhibits the reaction [AGT protein results in increased expression of VEGFA mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of VEGFA protein]; PD 123319 inhibits the reaction [Streptozocin results in increased expression of VEGFA mRNA]; PD 123319 inhibits the reaction [Streptozocin results in increased expression of VEGFA protein]

PMID:14638905 PMID:14718351

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

PhIP

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

RIKEN cDNA 4930438A08 gene like

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of 4930438A08RIKL mRNA

NCBI chr10:42,459,948...42,477,215
Ensembl chr10:42,459,781...42,477,177

G

alpha-2-macroglobulin

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of A2M mRNA

NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786

G

aminoadipate aminotransferase

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of AADAT mRNA

NCBI chr16:29,509,392...29,544,332
Ensembl chr16:29,509,394...29,544,332

G

ATP binding cassette subfamily B member 1A

affects transport
affects metabolic processing
multiple interactions

ABCB1A protein affects the transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
ABCB1A protein affects the metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
[ABCB1A protein affects the metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased abundance of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine; ABCB1A protein affects the susceptibility to [Dextran Sulfate co-treated with 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine]

PMID:18322075 PMID:30701287

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP-binding cassette, sub-family B member 1B

affects metabolic processing
multiple interactions

ABCB1B protein affects the metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
[ABCB1B protein affects the metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased abundance of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine; ABCB1B protein affects the susceptibility to [Dextran Sulfate co-treated with 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine]

NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199

G

ATP binding cassette subfamily C member 1

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ABCC1 mRNA

NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114

G

ATP binding cassette subfamily C member 2

increases transport
affects metabolic processing
multiple interactions
affects transport
increases expression

ABCC2 protein results in increased transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
ABCC2 protein affects the metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
[ABCC2 protein affects the metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased abundance of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine; ABCC2 protein affects the susceptibility to [Dextran Sulfate co-treated with 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine]
ABCC2 protein affects the transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
[Cyclosporine results in decreased activity of ABCC2 protein] which affects the transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ABCC2 mRNA

PMID:11306678 PMID:15057744 PMID:16356829 PMID:16611851 PMID:18680760 More...

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily C member 3

affects metabolic processing
multiple interactions

ABCC3 protein affects the metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
[ABCC3 protein affects the metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased abundance of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine; ABCC3 protein affects the susceptibility to [Dextran Sulfate co-treated with 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine]

NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595

G

ATP binding cassette subfamily G member 2

decreases expression
multiple interactions
affects metabolic processing
decreases transport
increases expression
increases transport
affects transport
increases secretion
affects abundance
affects response to substance

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of ABCG2 protein
[ABCG2 protein affects the metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased abundance of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine; ABCG2 protein affects the susceptibility to [Dextran Sulfate co-treated with 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine]
ABCG2 gene polymorphism results in decreased transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine; ABCG2 protein results in decreased transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ABCG2 mRNA
ABCG2 protein results in increased transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
ABCG2 protein affects the transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
ABCG2 protein results in increased secretion of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; [3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased activity of ABCG2 protein] which results in increased transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine; Beclomethasone inhibits the reaction [ABCG2 protein affects the transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine]; Cadmium Chloride inhibits the reaction [ABCG2 protein results in increased transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine]; Dexamethasone inhibits the reaction [ABCG2 protein affects the transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine]; Estradiol inhibits the reaction [ABCG2 protein affects the transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine]; Methylprednisolone inhibits the reaction [ABCG2 protein affects the transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine]; Triamcinolone inhibits the reaction [ABCG2 protein affects the transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine]
ABCG2 protein affects the abundance of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
ABCG2 results in increased transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
ABCG2 affects the susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine

PMID:14559835 PMID:15365089 PMID:15722455 PMID:18322075 PMID:18680760 More...

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

acetyl-CoA acyltransferase 1A

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of ACAA1A mRNA

NCBI chr 8:119,079,401...119,088,626
Ensembl chr 8:119,079,775...119,088,624

G

acyl-CoA dehydrogenase family, member 8

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ACAD8 mRNA

NCBI chr 8:25,382,271...25,406,404
Ensembl chr 8:25,382,273...25,406,414

G

acyl-CoA dehydrogenase medium chain

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of ACADM mRNA

NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147

G

acyl-CoA dehydrogenase short chain

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of ACADS mRNA

NCBI chr12:41,493,650...41,502,897
Ensembl chr12:41,493,626...41,502,898

G

aminocarboxymuconate semialdehyde decarboxylase

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ACMSD mRNA

NCBI chr13:39,200,412...39,245,954
Ensembl chr13:39,200,314...39,245,209

G

acyl-CoA synthetase family member 3

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of ACSF3 mRNA

NCBI chr19:50,835,116...50,875,557
Ensembl chr19:50,835,221...50,875,553

G

actin, alpha 1, skeletal muscle

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of ACTA1 mRNA

NCBI chr19:51,883,709...51,886,735
Ensembl chr19:51,883,715...51,886,742

G

actin alpha 2, smooth muscle

increases expression
decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ACTA2 mRNA
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of ACTA2 mRNA

PMID:15059925 PMID:15215175

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

actin, beta

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ACTB mRNA

NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877

G

actin, gamma 1

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ACTG1 mRNA

NCBI chr10:105,619,738...105,622,587
Ensembl chr10:105,619,737...105,624,232
Ensembl chr 3:105,619,737...105,624,232

G

actin gamma 2, smooth muscle

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of ACTG2 mRNA

PMID:15059925 PMID:29877212

NCBI chr 4:116,021,832...116,046,475
Ensembl chr 4:116,021,832...116,046,465

G

actinin alpha 4

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ACTN4 mRNA

NCBI chr 1:84,182,783...84,251,867
Ensembl chr 1:84,182,788...84,251,847

G

adenylate cyclase 5

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of ADCY5 mRNA

NCBI chr11:65,471,612...65,618,877
Ensembl chr11:65,471,612...65,618,974

G

adenylosuccinate synthase 1

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ADSS1 mRNA

NCBI chr 6:131,679,795...131,702,012
Ensembl chr 6:131,679,701...131,701,998

G

aryl hydrocarbon receptor

multiple interactions
affects response to substance

[3'-methoxy-4'-nitroflavone results in decreased activity of AHR protein] which results in decreased susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine; AHR mutant form inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A1 mRNA]; AHR mutant form inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A2 mRNA]
AHR protein affects the susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine

PMID:20816883 PMID:23208499

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

aryl-hydrocarbon receptor repressor

affects response to substance

AHRR protein affects the susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine

NCBI chr 1:28,993,634...29,088,673
Ensembl chr 1:28,993,634...29,088,673

G

A-kinase anchoring protein 12

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of AKAP12 mRNA

NCBI chr 1:40,730,123...40,819,863
Ensembl chr 1:40,730,123...40,819,886

G

AKT serine/threonine kinase 1

multiple interactions

[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Insulin] results in decreased phosphorylation of AKT1 protein

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

AKT serine/threonine kinase 2

multiple interactions

[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Insulin] results in decreased phosphorylation of AKT2 protein

NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817

G

AKT serine/threonine kinase 3

multiple interactions

[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Insulin] results in decreased phosphorylation of AKT3 protein

NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708

G

albumin

affects binding
increases expression
decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine binds to ALB protein
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ALB mRNA
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of ALB mRNA

PMID:8921513 PMID:15215175 PMID:27028147

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

aldehyde dehydrogenase 1 family, member A3

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ALDH1A3 mRNA

NCBI chr 1:119,982,272...120,017,416
Ensembl chr 1:119,982,277...120,017,436

G

aldehyde dehydrogenase 1 family, member B1

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of ALDH1B1 mRNA

NCBI chr 5:60,063,370...60,068,378
Ensembl chr 5:60,063,225...60,068,378

G

aldehyde dehydrogenase 2 family member

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of ALDH2 mRNA

NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521

G

aldehyde dehydrogenase 3 family, member A1

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ALDH3A1 mRNA

PMID:20816883 PMID:33945839

NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681

G

aldehyde dehydrogenase 3 family, member A2

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of ALDH3A2 mRNA

NCBI chr10:45,928,313...45,949,366
Ensembl chr10:45,908,524...45,949,281

G

aldehyde dehydrogenase 3 family, member B1

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of ALDH3B1 mRNA

NCBI chr 1:201,145,309...201,162,675
Ensembl chr 1:201,145,309...201,163,921

G

aldehyde dehydrogenase 6 family, member A1

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of ALDH6A1 mRNA

NCBI chr 6:104,077,975...104,098,636
Ensembl chr 6:104,077,979...104,098,656

G

aldehyde dehydrogenase 7 family, member A1

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ALDH7A1 mRNA

NCBI chr18:50,003,242...50,042,193
Ensembl chr18:50,009,934...50,042,193

G

aldehyde dehydrogenase 9 family, member A1

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of ALDH9A1 mRNA

NCBI chr13:79,505,738...79,522,539
Ensembl chr13:79,505,695...79,540,568

G

aldolase, fructose-bisphosphate A

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ALDOA mRNA

NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182

G

arachidonate 5-lipoxygenase

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of ALOX5 mRNA

NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743

G

amelogenin, X-linked

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of AMELX mRNA

NCBI chr X:25,076,362...25,087,660
Ensembl chr X:25,076,362...25,087,660

G

angiopoietin-like 4

multiple interactions
increases methylation

[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased methylation of ANGPTL4 promoter] which results in decreased expression of ANGPTL4 mRNA; [decitabine co-treated with trichostatin A] inhibits the reaction [[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased methylation of ANGPTL4 promoter] which results in decreased expression of ANGPTL4 mRNA]

NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519

G

annexin A1

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ANXA1 mRNA

NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343

G

amine oxidase, copper containing 1

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of AOC1 mRNA

NCBI chr 4:77,812,260...77,831,846
Ensembl chr 4:77,812,260...77,831,840

G

amine oxidase, copper containing 3

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of AOC3 mRNA

NCBI chr10:86,272,757...86,280,702

G

apoptotic peptidase activating factor 1

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of APAF1 mRNA

NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540

G

APC regulator of WNT signaling pathway

increases mutagenesis
multiple interactions
affects response to substance

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased mutagenesis of APC gene
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased mutagenesis of APC; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased mutagenesis of APC gene
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in increased mutagenesis of APC gene
APC protein affects the susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine

PMID:7846077 PMID:8608549 PMID:9163695 PMID:9202738 PMID:11181456 More...

NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696

G

apolipoprotein C2

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of APOC2 mRNA

NCBI chr 1:79,329,429...79,334,397
Ensembl chr 1:79,329,428...79,334,476

G

amyloid beta precursor protein

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of APP protein; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of APP protein modified form

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

adenine phosphoribosyl transferase

multiple interactions

[CYP1A2 protein co-treated with 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] results in increased mutagenesis of APRT gene

NCBI chr19:50,626,201...50,628,491
Ensembl chr19:50,626,202...50,628,431

G

aquaporin 1

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of AQP1 mRNA

NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690

G

Rho guanine nucleotide exchange factor 1

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ARHGEF1 mRNA

NCBI chr 1:80,499,026...80,520,954
Ensembl chr 1:80,499,131...80,520,953

G

Rho guanine nucleotide exchange factor 3

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ARHGEF3 mRNA

NCBI chr16:2,301,573...2,581,951
Ensembl chr16:2,300,138...2,581,945

G

achaete-scute family bHLH transcription factor 2

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ASCL2 mRNA

NCBI chr 1:198,148,999...198,151,406
Ensembl chr 1:198,148,999...198,151,406

G

activating transcription factor 4

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ATF4 mRNA

NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446

G

activating transcription factor 7 interacting protein

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ATF7IP mRNA

NCBI chr 4:169,385,872...169,471,652
Ensembl chr 4:169,385,872...169,471,650

G

atlastin GTPase 1

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ATL1 mRNA

NCBI chr 6:88,377,168...88,475,242
Ensembl chr 6:88,377,239...88,475,204

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ATP2A1 mRNA

NCBI chr 1:181,026,606...181,044,859
Ensembl chr 1:181,026,608...181,044,838

G

ATP synthase F1 subunit beta

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ATP5F1B mRNA

NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273

G

ATP synthase inhibitory factor subunit 1

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ATP5IF1 mRNA

NCBI chr 5:144,738,950...144,742,668
Ensembl chr 5:144,738,950...144,742,668

G

ATP synthase membrane subunit c locus 1

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ATP5MC1 mRNA

NCBI chr10:81,024,056...81,026,780
Ensembl chr10:81,023,925...81,027,124
Ensembl chr10:81,023,925...81,027,124

G

ATP synthase membrane subunit c locus 3

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ATP5MC3 mRNA

NCBI chr 3:58,810,535...58,813,185
Ensembl chr 3:58,810,535...58,814,279

G

ATP synthase peripheral stalk-membrane subunit b

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ATP5PB mRNA

NCBI chr 2:193,424,138...193,435,418
Ensembl chr 2:193,424,047...193,435,418

G

ATR serine/threonine kinase

multiple interactions
affects expression

myricetin affects the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine affects the expression of ATR mRNA]

NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136

G

AU RNA binding methylglutaconyl-CoA hydratase

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of AUH mRNA

NCBI chr17:12,329,522...12,424,882
Ensembl chr17:12,329,524...12,424,896

G

beta-1,4-N-acetyl-galactosaminyl transferase 2

increases mutagenesis

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased mutagenesis of B4GALNT2

NCBI chr10:80,801,594...80,828,005
Ensembl chr10:80,802,941...80,857,700

G

beta-secretase 1

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of BACE1 protein

NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876

G

BAG cochaperone 1

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of BAG1 mRNA

NCBI chr 5:56,068,494...56,081,075
Ensembl chr 5:56,068,494...56,081,075

G

brain abundant, membrane attached signal protein 1

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of BASP1 mRNA

NCBI chr 2:75,816,130...75,863,801
Ensembl chr 2:75,816,122...75,864,043

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of BAX mRNA; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of BAX protein
Hexachlorocyclohexane promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of BAX protein]
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with [Dexamethasone co-treated with INS protein co-treated with PRL protein]] results in decreased expression of BAX protein

PMID:11751460 PMID:16120219 PMID:18174961

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCAS3, microtubule associated cell migration factor

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of BCAS3 mRNA

NCBI chr10:70,213,710...70,673,080
Ensembl chr10:70,214,098...70,673,080

G

BCL2, apoptosis regulator

multiple interactions
increases expression

[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with [Dexamethasone co-treated with INS protein co-treated with PRL protein]] results in increased expression of BCL2 protein
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of BCL2 mRNA; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of BCL2 protein

PMID:11751460 PMID:18174961 PMID:23810796

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

basonuclin zinc finger protein 2

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of BNC2 mRNA

NCBI chr 5:98,679,071...99,016,044
Ensembl chr 5:98,687,410...99,079,426

G

BRCA1, DNA repair associated

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of BRCA1 protein

NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304

G

basic transcription factor 3

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of BTF3 mRNA

NCBI chr 2:29,659,764...29,666,898
Ensembl chr 2:29,659,231...29,666,879
Ensembl chr13:29,659,231...29,666,879

G

butyrophilin, subfamily 1, member A1

increases expression
decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of BTN1A1 mRNA
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of BTN1A1 mRNA

NCBI chr17:41,653,499...41,664,246
Ensembl chr17:41,654,249...41,664,272

G

BUB1 mitotic checkpoint serine/threonine kinase

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of BUB1 mRNA

NCBI chr 3:115,020,254...115,051,650
Ensembl chr 3:115,020,254...115,051,650

G

BUB1 mitotic checkpoint serine/threonine kinase B

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of BUB1B mRNA

NCBI chr 3:105,563,089...105,615,547
Ensembl chr 3:105,563,138...105,615,547

G

bystin-like

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of BYSL mRNA

NCBI chr 9:13,382,806...13,392,557
Ensembl chr 9:13,382,557...13,394,339

G

basic leucine zipper and W2 domains 2

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of BZW2 mRNA

NCBI chr 6:52,828,069...52,888,599
Ensembl chr 6:52,827,661...52,888,628

G

C1q and TNF related 3

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of C1QTNF3 mRNA

NCBI chr 2:59,917,099...59,939,519
Ensembl chr 2:59,917,188...59,939,433

G

calcium binding protein 39-like

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of CAB39L mRNA

NCBI chr15:33,606,588...33,710,518
Ensembl chr15:33,606,694...33,743,545

G

calcium voltage-gated channel auxiliary subunit alpha2delta 1

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of CACNA2D1 mRNA

NCBI chr 4:18,950,611...19,374,969
Ensembl chr 4:18,951,002...19,374,969

G

capping actin protein, gelsolin like

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of CAPG mRNA

NCBI chr 4:104,594,743...104,611,856
Ensembl chr 4:104,594,753...104,611,856

G

cell cycle associated protein 1

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CAPRIN1 mRNA

NCBI chr 3:90,152,305...90,230,447
Ensembl chr 3:90,153,620...90,230,502

G

carbonic anhydrase 2

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CA2 mRNA

NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818

G

carbonic anhydrase 4

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of CAR4 mRNA

NCBI chr10:69,827,945...69,836,501
Ensembl chr10:69,827,945...69,836,501

G

calcium/calmodulin dependent serine protein kinase

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CASK mRNA

NCBI chr X:8,899,500...9,243,014
Ensembl chr X:8,899,833...9,238,694

G

caspase 3

multiple interactions
increases activity

[2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline co-treated with 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] results in increased activity of CASP3 protein
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in increased expression of CASP3 protein modified form
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased activity of CASP3 protein

PMID:18616682 PMID:20307560

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of CASP8 mRNA

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

catalase

increases activity
decreases expression
multiple interactions

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased activity of CAT protein
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of CAT mRNA
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Buprenorphine] results in increased activity of CAT protein

PMID:23313794 PMID:32113805 PMID:33945839

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 20

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CCL20 mRNA

NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629

G

cyclin A2

increases expression
decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CCNA2 protein
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CCNA2 mRNA
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of CCNA2 protein

PMID:10728688 PMID:16120219 PMID:29877212

NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577

G

cyclin B1

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CCNB1 protein

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

G

cyclin B2

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CCNB2 mRNA

NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874

G

cyclin D1

increases expression
increases expression
multiple interactions

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CCND1 protein
PhIP increases expression of Ccnd1 mRNA and protein in rat mammary gland
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in increased expression of CCND1 mRNA; Plant Preparations inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CCND1 mRNA]
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CCND1 mRNA; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CCND1 protein

CTD
RGD

PMID:12097258 PMID:12376462 PMID:14522882 PMID:18283038 PMID:21081470 More...

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin D2

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CCND2 mRNA

NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495

G

cyclin H

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CCNH mRNA; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CCNH protein

NCBI chr 2:15,835,064...15,855,648
Ensembl chr 2:15,834,833...15,855,819

G

chaperonin containing TCP1 subunit 2

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CCT2 mRNA

NCBI chr 7:52,692,725...52,705,478
Ensembl chr 7:52,692,725...52,706,944

G

chaperonin containing TCP1 subunit 4

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CCT4 mRNA

NCBI chr14:96,991,853...97,004,732
Ensembl chr14:96,991,859...97,005,267

G

chaperonin containing TCP1 subunit 5

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CCT5 mRNA

NCBI chr 2:82,591,750...82,602,903
Ensembl chr 2:82,590,630...82,602,930

G

chaperonin containing TCP1 subunit 7

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CCT7 mRNA

NCBI chr 4:117,989,232...118,006,478
Ensembl chr 4:117,989,232...118,006,580

G

chaperonin containing TCP1 subunit 8

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CCT8 mRNA

NCBI chr11:26,710,370...26,722,079
Ensembl chr11:26,710,370...26,722,079

G

CD24 molecule

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CD24A mRNA

NCBI chr20:47,074,353...47,079,662
Ensembl chr20:47,073,512...47,079,662

G

CD27 molecule

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CD27 mRNA

NCBI chr 4:158,030,700...158,035,862
Ensembl chr 4:158,030,703...158,035,592

G

CD74 molecule

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of CD74 mRNA

NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003

G

Cd81 molecule

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CD81 mRNA

NCBI chr 1:198,235,861...198,251,660
Ensembl chr 1:198,241,484...198,251,660

G

cell division cycle 25C

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CDC25C mRNA

NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185

G

cell division cycle 34, ubiqiutin conjugating enzyme

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CDC34 mRNA

NCBI chr 7:10,017,588...10,023,586
Ensembl chr 7:10,017,588...10,023,186

G

cell division cycle 45

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CDC45 mRNA

NCBI chr11:82,185,427...82,210,630
Ensembl chr11:82,185,473...82,210,619

G

cell division cycle associated 3

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CDCA3 mRNA

NCBI chr 4:157,634,775...157,638,799
Ensembl chr 4:157,634,928...157,638,799

G

cadherin 1

multiple interactions
decreases expression

U 0126 inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of CDH1 protein]

PMID:22307971 PMID:22581815

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

cadherin 26

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of CDH26 mRNA

NCBI chr 3:165,520,523...165,573,191
Ensembl chr 3:165,520,439...165,572,149

G

cyclin-dependent kinase 1

decreases expression
increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of CDK1 mRNA
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CDK1 mRNA

PMID:20816883 PMID:29877212

NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408

G

cyclin-dependent kinase 13

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CDK13 mRNA

NCBI chr17:47,251,145...47,344,675
Ensembl chr17:47,251,163...47,341,721

G

cyclin-dependent kinase 2 associated protein 1

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CDK2AP1 mRNA

NCBI chr12:32,249,752...32,258,483
Ensembl chr12:32,249,747...32,258,479

G

cyclin-dependent kinase 4

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CDK4 mRNA; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CDK4 protein

PMID:12376462 PMID:14522882

NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403

G

cyclin-dependent kinase 9

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of CDK9 mRNA

NCBI chr 3:15,996,467...16,001,315
Ensembl chr 3:15,996,468...16,002,410

G

cyclin-dependent kinase inhibitor 1A

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CDKN1A mRNA; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CDKN1A protein

PMID:11425520 PMID:15635149 PMID:17156947 PMID:23810796 PMID:29877212

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 2A

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of CDKN2A mRNA; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of CDKN2A protein

NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149

G

CCAAT/enhancer binding protein beta

affects response to substance
increases phosphorylation

CEBPB protein affects the susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased phosphorylation of CEBPB protein

NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473

G

centromere protein F

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CENPF mRNA

NCBI chr13:101,184,127...101,229,714
Ensembl chr13:101,184,127...101,229,669

G

centrosomal protein 290

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CEP290 mRNA

NCBI chr 7:35,310,071...35,399,388
Ensembl chr 7:35,310,199...35,399,392

G

complement factor H-related 4

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of CFHR4 mRNA

NCBI chr13:51,422,592...51,491,476
Ensembl chr13:51,422,592...51,491,502

G

ChaC glutathione specific gamma-glutamylcyclotransferase 2

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of CHAC2 mRNA

NCBI chr14:104,720,754...104,728,305
Ensembl chr14:104,720,758...104,728,301

G

choline O-acetyltransferase

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CHAT mRNA

NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093

G

checkpoint kinase 1

increases phosphorylation

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased phosphorylation of CHEK1 protein

NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009

G

checkpoint kinase 2

increases phosphorylation

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased phosphorylation of CHEK2 protein

NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286

G

cholinergic receptor nicotinic beta 2 subunit

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CHRNB2 mRNA

NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619

G

cytoskeleton associated protein 2

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CKAP2 mRNA

NCBI chr16:69,839,668...69,864,852
Ensembl chr16:69,839,630...69,864,913

G

creatine kinase, M-type

increases expression
decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CKM mRNA
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of CKM mRNA

PMID:15059925 PMID:15215175

NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720

G

CDC28 protein kinase regulatory subunit 2

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CKS2 mRNA

NCBI chr17:13,570,611...13,575,770

G

claudin 14

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of CLDN14 mRNA

NCBI chr11:33,232,281...33,329,440
Ensembl chr11:33,232,220...33,329,171

G

claudin 3

multiple interactions

[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in decreased expression of CLDN3 mRNA

NCBI chr12:21,708,538...21,710,010
Ensembl chr12:21,708,398...21,711,001

G

CDC-like kinase 2

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CLK2 mRNA

NCBI chr 2:174,570,614...174,582,645
Ensembl chr 2:174,570,653...174,588,985

G

CCHC-type zinc finger, nucleic acid binding protein

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CNBP mRNA

NCBI chr 4:120,302,768...120,311,694
Ensembl chr 4:120,302,771...120,311,637

G

carnosine dipeptidase 1

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of CNDP1 mRNA

NCBI chr18:77,984,886...78,030,837
Ensembl chr18:77,984,907...78,007,765

G

calponin 1

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CNN1 mRNA

NCBI chr 8:20,632,434...20,641,097
Ensembl chr 8:20,632,338...20,641,098

G

calponin 3

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CNN3 mRNA

NCBI chr 2:209,518,948...209,550,107
Ensembl chr 2:209,518,948...209,550,104

G

collagen type XII alpha 1 chain

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of COL12A1 mRNA

NCBI chr 8:80,547,592...80,665,665
Ensembl chr 8:80,547,593...80,665,686

G

collagen type I alpha 1 chain

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of COL1A1 mRNA

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

collagen type I alpha 2 chain

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of COL1A2 mRNA

NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867

G

collagen type II alpha 1 chain

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of COL2A1 mRNA

NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546

G

collagen type V alpha 1 chain

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of COL5A1 mRNA

NCBI chr 3:11,208,429...11,356,715
Ensembl chr 3:11,208,512...11,354,588

G

catechol-O-methyltransferase

affects response to substance

COMT protein affects the susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine

NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642

G

coronin 1A

increases methylation
multiple interactions

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased methylation of CORO1A promoter
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased methylation of CORO1A promoter] which results in decreased expression of CORO1A mRNA

NCBI chr 1:181,295,561...181,300,566
Ensembl chr 1:181,295,562...181,300,534

G

cytochrome c oxidase subunit 6C

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of COX6C mRNA

NCBI chr 7:67,129,265...67,142,001
Ensembl chr 7:67,111,024...67,141,963

G

cytochrome c oxidase subunit 7A2

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of COX7A2 mRNA

NCBI chr 8:80,716,824...80,720,922
Ensembl chr14:51,301,168...51,301,633
Ensembl chr 8:51,301,168...51,301,633

G

cytochrome c oxidase subunit 7C

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of COX7C mRNA

NCBI chr 2:16,841,771...16,843,796
Ensembl chr 2:16,840,837...16,843,760

G

crystallin, alpha B

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of CRYAB mRNA

NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157

G

casein alpha s1

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CSN1S1 mRNA

NCBI chr14:20,343,620...20,359,614
Ensembl chr14:20,343,619...20,359,614

G

casein beta

multiple interactions
increases expression
decreases expression

[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] affects the expression of CSN2 mRNA
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CSN2 mRNA
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of CSN2 mRNA

PMID:9879772 PMID:15215175

NCBI chr14:20,322,581...20,329,818
Ensembl chr14:20,322,581...20,329,817

G

casein kappa

decreases expression
increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of CSN3 mRNA
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CSN3 mRNA

NCBI chr14:20,154,032...20,160,585
Ensembl chr14:20,154,032...20,160,587

G

catenin beta 1

multiple interactions
increases expression
increases mutagenesis

[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dextran Sulfate] results in increased expression of CTNNB1 protein; [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dextran Sulfate] results in increased mutagenesis of CTNNB1 gene; CTNNB1 gene mutant form results in increased susceptibility to [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dextran Sulfate]
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] affects the localization of CTNNB1 protein; [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in increased expression of CTNNB1 mRNA; [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in increased expression of CTNNB1 protein; [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in increased mutagenesis of CTNNB1 gene; Plant Preparations inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CTNNB1 mRNA]
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CTNNB1 mRNA; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CTNNB1 protein
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased mutagenesis of CTNNB1 gene

PMID:9515794 PMID:10965019 PMID:11756241 PMID:14507667 PMID:15459021 More...

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

cathepsin D

multiple interactions
increases expression

[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in decreased expression of CTSD mRNA
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CTSD protein

PMID:12097258 PMID:20951759

NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488

G

C-X-C motif chemokine ligand 10

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CXCL10 mRNA

NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975

G

C-X-C motif chemokine receptor 3

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CXCR3 mRNA

NCBI chr X:66,844,318...66,846,969
Ensembl chr X:66,844,318...66,846,969

G

cytochrome P450, family 19, subfamily a, polypeptide 1

multiple interactions

[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Ethanol] results in increased activity of CYP19A1 protein

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases activity
decreases expression
affects metabolic processing
increases expression
multiple interactions
increases hydroxylation
increases metabolic processing

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased activity of CYP1A1 protein; CYP1A1 results in increased activity of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of CYP1A1 mRNA
CYP1A1 gene SNP affects the metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A1 mRNA
CYP1A1 protein results in increased metabolism of and results in increased activity of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine; lead nitrate inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A1 protein]
CYP1A1 protein results in increased hydroxylation of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
[CYP1A1 protein results in increased hydroxylation of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased chemical synthesis of 2-amino-1-methyl-6-(4-hydroxyphenyl)imidazo(4,5-b)pyridine; [CYP1A1 protein results in increased hydroxylation of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased chemical synthesis of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine
CYP1A1 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
[2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline co-treated with 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] results in increased expression of CYP1A1 mRNA; [[CYP1A2 protein co-treated with CYP1A1 protein] results in increased hydroxylation of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased chemical synthesis of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine; [Benzo(a)pyrene co-treated with 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] results in increased expression of CYP1A1 mRNA; [CYP1A1 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased chemical synthesis of 2-amino-1-methyl-6-(4-hydroxyphenyl)imidazo(4,5-b)pyridine; [CYP1A1 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased chemical synthesis of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine; [CYP1A2 protein co-treated with CYP1A1 protein] results in increased hydroxylation of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine; AHR mutant form inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A1 mRNA]; xanthohumol promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A1 mRNA]

PMID:1913651 PMID:2334931 PMID:8902619 PMID:15598703 PMID:16167840 More...

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

increases hydroxylation
affects metabolic processing
increases expression
multiple interactions
affects oxidation
increases activity
increases response to substance
increases metabolic processing
affects response to substance
increases oxidation

CYP1A2 protein results in increased hydroxylation of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
CYP1A2 gene SNP affects the metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A2 mRNA
[1-Naphthylisothiocyanate co-treated with 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] results in decreased expression of CYP1A2 protein; [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with 1-Naphthylisothiocyanate] results in decreased expression of CYP1A2 protein; Caffeine promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A2 mRNA]; CYP1A2 protein results in increased metabolism of and results in increased activity of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine; lead nitrate inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A2 mRNA]; lead nitrate inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A2 protein]
CYP1A2 affects the oxidation of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A2 mRNA; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A2 protein
CYP1A2 protein results in increased activity of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
CYP1A2 protein results in increased susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
CYP1A2 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
[CYP1A2 protein co-treated with 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] results in increased mutagenesis of APRT gene; [CYP1A2 protein results in increased hydroxylation of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased chemical synthesis of 2-amino-1-methyl-6-(4-hydroxyphenyl)imidazo(4,5-b)pyridine; [CYP1A2 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased abundance of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine; CYP1A2 protein results in increased metabolism of and results in increased activity of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
CYP1A2 protein polymorphism results in increased activity of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine; CYP1A2 protein results in increased activity of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine; CYP1A2 results in increased activity of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
CYP1A2 protein affects the susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
CYP1A2 results in increased oxidation of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [CYP1A2 protein results in decreased ethylation of Phenacetin]; [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CYP1A2 mRNA; [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with CYP1A2 protein] results in increased mutagenesis of HPRT1 gene; [[CYP1A2 protein co-treated with CYP1A1 protein] results in increased hydroxylation of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased chemical synthesis of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine; [CYP1A2 protein co-treated with CYP1A1 protein] results in increased hydroxylation of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine; [CYP1A2 protein co-treated with POR protein co-treated with OAT protein] results in increased susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine; [CYP1A2 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased chemical synthesis of 2-amino-1-methyl-6-(4-hydroxyphenyl)imidazo(4,5-b)pyridine; [CYP1A2 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased chemical synthesis of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine; [CYP1A2 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased chemical synthesis of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine metabolite; AHR mutant form inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A2 mRNA]; alpha-naphthoflavone inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A2 mRNA]; CYP1A2 protein results in increased hydroxylation of and results in increased activity of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine; CYP1A2 protein results in increased hydroxylation of and results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine; CYP1A2 protein results in increased metabolism of and results in increased activity of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine; CYP1A2 protein results in increased metabolism of and results in increased susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine; CYP1A2 protein results in increased oxidation of and results in increased activity of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine; furafylline inhibits the reaction [CYP1A2 protein results in increased hydroxylation of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine]

PMID:1913651 PMID:1943715 PMID:2023932 PMID:2334931 PMID:8020169 More...

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

multiple interactions
decreases expression
increases metabolic processing
increases activity
increases expression

[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CYP1B1 mRNA; [CYP1B1 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased chemical synthesis of 2-amino-1-methyl-6-(4-hydroxyphenyl)imidazo(4,5-b)pyridine; [CYP1B1 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased chemical synthesis of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine; Fulvestrant inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1B1 mRNA]; IL6 protein promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1B1 mRNA]
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of CYP1B1 mRNA
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased activity of CYP1B1 protein

PMID:17279779 PMID:20307560 PMID:20702593 PMID:20816883 PMID:29362861 More...

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 27, subfamily b, polypeptide 1

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of CYP27B1 mRNA

NCBI chr 7:62,869,340...62,876,242
Ensembl chr 7:62,871,297...62,876,241

G

cytochrome P450, family 2, subfamily b, polypeptide 2

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP2B2 protein

NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566

G

cytochrome P450, family 2, subfamily C, polypeptide 6

increases metabolic processing
multiple interactions

CYP2C19 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
[CYP2C19 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased chemical synthesis of 2-amino-1-methyl-6-(4-hydroxyphenyl)imidazo(4,5-b)pyridine; [CYP2C19 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased chemical synthesis of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 2, subfamily d, polypeptide 4

increases metabolic processing
multiple interactions

CYP2D6 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
[CYP2D6 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased chemical synthesis of 2-amino-1-methyl-6-(4-hydroxyphenyl)imidazo(4,5-b)pyridine

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

cytochrome P450, family 2, subfamily e, polypeptide 1

increases expression
multiple interactions

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP2E1 mRNA
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine promotes the reaction [Ethanol results in increased expression of CYP2E1 mRNA]; 5,15-diphenylporphyrin inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP2E1 mRNA]; Ethanol promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP2E1 mRNA]; fulvestrant inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP2E1 mRNA]

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions
increases expression

CYP3A4 protein results in increased metabolism of and results in increased activity of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP3A4 mRNA

PMID:1913651 PMID:29549414 PMID:31542801

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

DAB adaptor protein 2

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of DAB2 mRNA

NCBI chr 2:55,514,692...55,567,476
Ensembl chr 2:55,514,700...55,567,476

G

dystroglycan 1

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of DAG1 mRNA

NCBI chr 8:108,890,926...108,955,611
Ensembl chr 8:108,890,929...108,952,325

G

death-associated protein kinase 3

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of DAPK3 mRNA

NCBI chr 7:8,524,182...8,532,552
Ensembl chr 7:8,524,183...8,532,558

G

diazepam binding inhibitor

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of DBI mRNA

NCBI chr13:31,241,466...31,249,853
Ensembl chr13:31,206,988...31,268,693

G

DDB1 and CUL4 associated factor 1

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of DCAF1 mRNA

NCBI chr 8:107,466,229...107,540,633
Ensembl chr 8:107,474,312...107,540,627

G

decorin

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of DCN mRNA

NCBI chr 7:32,281,252...32,321,291
Ensembl chr 7:32,281,252...32,321,270

G

dopa decarboxylase

decreases activity
decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased activity of DDC protein
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of DDC mRNA

PMID:2243617 PMID:33945839

NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208

G

defensin alpha-like 1

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of DEFAL1 mRNA

NCBI chr16:70,371,492...70,372,481
Ensembl chr16:70,371,518...70,372,353

G

desmin

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of DES mRNA

NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699

G

dehydrogenase/reductase 2

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of DHRS2 mRNA

NCBI chr15:28,688,881...28,703,646
Ensembl chr15:28,688,940...28,703,644

G

DEAH-box helicase 15

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of DHX15 mRNA

NCBI chr14:58,787,147...58,825,083
Ensembl chr14:58,787,127...58,825,088

G

diaphanous-related formin 3

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of DIAPH3 mRNA

NCBI chr15:62,543,375...63,013,060
Ensembl chr15:62,543,375...63,012,975

G

death inducer-obliterator 1

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of DIDO1 mRNA

NCBI chr 3:167,772,535...167,825,894
Ensembl chr 3:167,772,770...167,817,218

G

discs large MAGUK scaffold protein 4

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of DLG4 protein

NCBI chr10:54,740,700...54,769,097
Ensembl chr10:54,739,470...54,767,153

G

deleted in malignant brain tumors 1

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of DMBT1 mRNA

NCBI chr 1:185,617,469...185,696,476
Ensembl chr 1:185,617,294...185,696,478

G

dynein, axonemal, heavy chain 11

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of DNAH11 mRNA

NCBI chr 6:138,839,175...139,155,554
Ensembl chr 6:138,839,177...139,155,536

G

DnaJ heat shock protein family (Hsp40) member B8

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of DNAJB8 mRNA

NCBI chr 4:120,681,918...120,685,108
Ensembl chr 4:120,681,926...120,687,552

G

DNA methyltransferase 1

increases expression
multiple interactions

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of DNMT1 protein
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in increased expression of DNMT1 mRNA

PMID:12097258 PMID:22581815

NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659

G

dihydropyrimidine dehydrogenase

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of DPYD mRNA

NCBI chr 2:206,609,043...207,474,982
Ensembl chr 2:206,609,122...207,474,982

G

endothelin 1

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of EDN1 mRNA

NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885

G

eukaryotic translation elongation factor 1 alpha 1

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of EEF1A1 mRNA

NCBI chr 8:79,341,554...79,344,784
Ensembl chr 8:79,341,557...79,344,839

G

EGF containing fibulin extracellular matrix protein 1

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of EFEMP1 mRNA

NCBI chr14:102,610,813...102,690,027
Ensembl chr14:102,610,908...102,690,018

G

epidermal growth factor

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of EGF mRNA

NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064

G

epidermal growth factor receptor

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of EGFR mRNA

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

early growth response 1

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of EGR1 mRNA

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

ets homologous factor

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of EHF mRNA

NCBI chr 3:89,639,845...89,680,061
Ensembl chr 3:89,641,833...89,679,997

G

eukaryotic translation initiation factor 5A

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of EIF5A mRNA

NCBI chr10:54,640,104...54,644,845
Ensembl chr10:54,640,024...54,644,656

G

enolase 1

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ENO1 mRNA

NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336
Ensembl chr 3:160,719,951...160,731,336

G

epoxide hydrolase 1

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of EPHX1 mRNA

NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235

G

EPS8 like 3

affects response to substance

EPS8L3 protein affects the susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine

NCBI chr 2:195,514,692...195,528,085
Ensembl chr 2:195,514,692...195,528,085

G

erb-b2 receptor tyrosine kinase 2

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ERBB2 mRNA

NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078

G

ERCC excision repair 1, endonuclease non-catalytic subunit

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of ERCC1 mRNA

NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963

G

ERH, mRNA splicing and mitosis factor

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ERH mRNA

NCBI chr 6:100,280,933...100,291,200
Ensembl chr 6:100,280,930...100,291,210

G

endoplasmic reticulum protein 44

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ERP44 mRNA

NCBI chr 5:62,516,550...62,610,762
Ensembl chr 5:62,516,551...62,610,761

G

estrogen receptor 1

multiple interactions
affects response to substance
increases expression
increases activity

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine binds to and results in increased activity of ESR1 protein; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [Estradiol binds to and results in increased activity of ESR1 protein]; [fulvestrant results in decreased expression of ESR1 protein] which results in decreased susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine; Estradiol inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine binds to ESR1 protein]; fulvestrant inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased activity of ESR1 protein]
ESR1 protein affects the susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ESR1 mRNA; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ESR1 protein

PMID:15319301 PMID:15637090 PMID:16533016 PMID:23208499

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ESR2 mRNA; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ESR2 protein

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

ezrin

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of EZR mRNA

NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505

G

coagulation factor II (thrombin) receptor

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of F2R mRNA

NCBI chr 2:26,869,343...26,885,856
Ensembl chr 2:26,868,404...26,885,870

G

fragile histidine triad diadenosine triphosphatase

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of FHIT mRNA

NCBI chr15:13,935,029...15,442,620
Ensembl chr15:13,934,995...15,442,340

G

fibronectin 1

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of FN1 mRNA

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

formin binding protein 1-like

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of FNBP1L mRNA

NCBI chr 2:210,647,241...210,748,203
Ensembl chr 2:210,647,246...210,738,455

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of FOS mRNA; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of FOS protein

PMID:20816883 PMID:23313794

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

forkhead box O1

decreases phosphorylation

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased phosphorylation of FOXO1 protein

NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790

G

furin (paired basic amino acid cleaving enzyme)

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of FURIN mRNA

NCBI chr 1:134,348,142...134,361,182
Ensembl chr 1:134,348,144...134,364,314

G

G0/G1switch 2

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of G0S2 mRNA

NCBI chr13:104,806,351...104,807,263
Ensembl chr13:104,806,156...104,807,451

G

glucose-6-phosphatase catalytic subunit 1

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of G6PC1 mRNA

NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804

G

GRB2-associated binding protein 1

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of GAB1 mRNA

NCBI chr19:27,131,262...27,239,236
Ensembl chr19:27,131,262...27,239,236

G

growth arrest and DNA-damage-inducible, alpha

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of GADD45A mRNA

NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115

G

growth associated protein 43

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of GAP43 mRNA

NCBI chr11:58,376,371...58,470,047
Ensembl chr11:58,376,371...58,470,045

G

glutaryl-CoA dehydrogenase

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of GCDH mRNA

NCBI chr19:23,263,215...23,269,689
Ensembl chr19:23,263,264...23,269,681

G

guanine deaminase

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of GDA mRNA

NCBI chr 1:218,903,045...218,982,360
Ensembl chr 1:218,906,815...218,982,416

G

gamma-glutamyl cyclotransferase

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of GGCT mRNA

NCBI chr 4:84,122,921...84,129,327
Ensembl chr 4:84,123,118...84,129,277

G

gamma-glutamyltransferase 1

increases expression
decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of GGT1 mRNA
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of GGT1 mRNA

PMID:12376462 PMID:33945839

NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442

G

gamma-glutamyltransferase 7

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of GGT7 mRNA

NCBI chr 3:143,978,073...144,004,597
Ensembl chr 3:143,978,082...144,001,492

G

glutamate-ammonia ligase

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of GLUL mRNA

NCBI chr13:65,969,053...66,035,121
Ensembl chr13:66,025,630...66,035,108

G

G protein subunit alpha 13

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of GNA13 mRNA

NCBI chr10:94,337,939...94,370,774
Ensembl chr10:94,337,725...94,370,774

G

G protein subunit alpha i2

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of GNAI2 mRNA

NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979

G

G protein subunit alpha transducin 1

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of GNAT1 mRNA

NCBI chr 8:108,350,935...108,355,671
Ensembl chr 8:108,350,935...108,355,671

G

glycine N-methyltransferase

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of GNMT mRNA

NCBI chr 9:14,254,675...14,258,028
Ensembl chr 9:14,254,675...14,258,434

G

golgin A4

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of GOLGA4 mRNA

NCBI chr 8:118,208,200...118,285,003

G

glypican 3

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of GPC3 mRNA

NCBI chr X:131,868,986...132,236,824
Ensembl chr X:131,868,990...132,236,798

G

G protein-coupled receptor 135

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of GPR135 mRNA

NCBI chr 6:90,627,533...90,630,661
Ensembl chr 6:90,629,178...90,630,551

G

glutathione peroxidase 1

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of GPX1 mRNA

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glutathione peroxidase 2

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of GPX2 mRNA; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of GPX2 protein

NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877

G

glutathione peroxidase 3

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of GPX3 mRNA

NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035

G

glutathione peroxidase 4

increases expression
decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of GPX4 mRNA
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of GPX4 mRNA

PMID:15215175 PMID:33945839

NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982

G

glutathione peroxidase 7

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of GPX7 mRNA

NCBI chr 5:123,145,151...123,153,141
Ensembl chr 5:123,144,331...123,153,004

G

glutathione peroxidase 8

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of GPX8 mRNA

NCBI chr 2:44,676,448...44,680,042
Ensembl chr 2:44,676,454...44,680,195

G

glutamate metabotropic receptor 3

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of GRM3 mRNA

NCBI chr 4:24,364,854...24,643,972
Ensembl chr 4:24,365,115...24,609,804

G

glutamate metabotropic receptor 4

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of GRM4 mRNA

NCBI chr20:5,484,172...5,572,821
Ensembl chr20:5,481,124...5,572,821

G

G1 to S phase transition 1

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of GSPT1 mRNA

NCBI chr10:4,362,528...4,397,215
Ensembl chr10:4,362,510...4,397,198

G

glutathione-disulfide reductase

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of GSR mRNA

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

glutathione synthetase

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of GSS mRNA

NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198

G

glutathione S-transferase alpha 1

affects response to substance
multiple interactions
decreases expression

GSTA1 gene polymorphism affects the susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
[xanthohumol co-treated with 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] results in increased expression of GSTA1 mRNA
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of GSTA1 mRNA

PMID:14601045 PMID:22138251

NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121

G

glutathione S-transferase alpha 3

decreases expression
increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of GSTA3 mRNA
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of GSTA3 mRNA

PMID:15215175 PMID:33945839

NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240

G

glutathione S-transferase alpha 4

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of GSTA4 mRNA

NCBI chr 8:79,066,967...79,084,193
Ensembl chr 8:79,066,934...79,084,182

G

glutathione S-transferase alpha 6

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of GSTA6 mRNA

NCBI chr 9:23,743,262...23,806,260
Ensembl chr 9:23,744,288...23,801,131

G

glutathione S-transferase kappa 1

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of GSTK1 mRNA

NCBI chr 4:71,118,979...71,123,298
Ensembl chr 4:71,118,896...71,123,292

G

glutathione S-transferase mu 1

affects response to substance

GSTM1 gene polymorphism affects the susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

glutathione S-transferase mu 2

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of GSTM2 mRNA

NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961

G

glutathione S-transferase mu 4

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of GSTM4 mRNA

NCBI chr 2:195,667,940...195,685,315
Ensembl chr 2:195,680,004...195,685,323

G

glutathione S-transferase, mu 5-like

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of GSTM5 mRNA

NCBI chr 2:195,544,424...195,549,895
Ensembl chr 2:195,544,426...195,628,961

G

glutathione S-transferase omega 1

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of GSTO1 mRNA

NCBI chr 1:246,721,089...246,731,228
Ensembl chr 1:246,721,221...246,731,468

G

glutathione S-transferase pi 1

multiple interactions
decreases expression
affects response to substance

[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in decreased expression of GSTP1 mRNA
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of GSTP1 mRNA
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of GSTP1 protein
GSTP1 protein affects the susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine

PMID:12097258 PMID:19223546 PMID:22581815 PMID:33945839

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

glutathione S-transferase theta 1

affects response to substance

GSTT1 gene polymorphism affects the susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine

NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585

G

guanylate cyclase 1 soluble subunit alpha 1

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of GUCY1A1 mRNA

NCBI chr 2:167,418,615...167,482,293
Ensembl chr 2:167,418,640...167,481,671

G

H2A.X variant histone

increases expression
increases phosphorylation

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of H2AX protein modified form
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased phosphorylation of H2AX protein

PMID:28160022 PMID:32466334 PMID:34510228

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239

G

H3.3 histone B

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of H3F3B mRNA

NCBI chr10:101,256,484...101,258,716
Ensembl chr10:101,256,480...101,258,709
Ensembl chr13:101,256,480...101,258,709

G

H3.4 histone, cluster member

decreases methylation
multiple interactions

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased methylation of H3-4 protein
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with 4-biphenylamine co-treated with Benzo(a)pyrene co-treated with Tetrachlorodibenzodioxin] results in decreased methylation of H3-4 protein

NCBI chr10:43,740,702...43,741,262

G

3-hydroxyanthranilate 3,4-dioxygenase

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of HAAO mRNA

NCBI chr 6:10,845,235...10,864,863
Ensembl chr 6:10,845,771...10,864,877

G

hydroxyacyl-CoA dehydrogenase

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of HADH mRNA

NCBI chr 2:219,787,935...219,830,335
Ensembl chr 2:219,787,927...219,830,353

G

hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of HADHB mRNA

NCBI chr 6:26,153,572...26,187,668
Ensembl chr 6:26,153,578...26,184,869

G

hemoglobin alpha, adult chain 2

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of HBA1 mRNA

NCBI chr10:15,323,830...15,324,677
Ensembl chr10:15,307,815...15,338,392
Ensembl chr10:15,307,815...15,338,392

G

hemoglobin subunit beta

multiple interactions
decreases expression
affects response to substance

kaempferol inhibits the reaction [HBB gene polymorphism results in increased susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine]; Quercetin inhibits the reaction [HBB gene polymorphism results in increased susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine]
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of HBB mRNA; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of HBB-B1 mRNA
HBB protein affects the susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine

PMID:14691983 PMID:15215175 PMID:29877212

NCBI chr 1:158,250,421...158,251,832
Ensembl chr 1:158,120,200...158,252,012

G

holocytochrome c synthase

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of HCCS mRNA

NCBI chr X:24,932,943...24,942,376
Ensembl chr X:24,933,002...24,942,366

G

HemK methyltransferase family member 1

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of HEMK1 mRNA

NCBI chr 8:107,999,658...108,010,732
Ensembl chr 8:107,999,644...108,010,256

G

3-hydroxyisobutyryl-CoA hydrolase

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of HIBCH mRNA

NCBI chr 9:48,590,097...48,669,896
Ensembl chr 9:48,590,099...48,669,824

G

hypoxia inducible factor 1 subunit alpha

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of HIF1A protein

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

high mobility group box 2

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of HMGB2 mRNA; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of HMGB2 protein

NCBI chr16:32,710,651...32,713,230
Ensembl chr16:32,710,658...32,713,140
Ensembl chr 1:32,710,658...32,713,140

G

3-hydroxy-3-methylglutaryl-CoA lyase like 1

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of HMGCLL1 mRNA

NCBI chr 8:76,757,301...76,887,300
Ensembl chr 8:76,757,497...76,886,816

G

3-hydroxy-3-methylglutaryl-CoA synthase 2

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of HMGCS2 mRNA

NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130

G

high mobility group nucleosome binding domain 1

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of HMGN1 mRNA

NCBI chr11:35,422,328...35,428,247
Ensembl chr11:35,422,328...35,428,254

G

high mobility group nucleosomal binding domain 2

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of HMGN2 mRNA

NCBI chr 5:146,192,126...146,195,580
Ensembl chr 5:146,192,126...146,195,521
Ensembl chr16:146,192,126...146,195,521

G

heme oxygenase 1

multiple interactions
increases expression

[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of HMOX1 mRNA
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of HMOX1 mRNA
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in decreased expression of HMOX1 mRNA

PMID:12097258 PMID:20307560

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

HNF1 homeobox B

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of HNF1B mRNA

NCBI chr10:68,735,894...68,789,888
Ensembl chr10:68,735,894...68,789,888

G

hypoxanthine phosphoribosyltransferase 1

increases mutagenesis
multiple interactions

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased mutagenesis of HPRT1 gene; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased mutagenesis of HPRT1 intron
Ascorbic Acid inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased mutagenesis of HPRT1 gene]; beta Carotene inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased mutagenesis of HPRT1 gene]; Vitamin E inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased mutagenesis of HPRT1 gene]
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with CYP1A2 protein] results in increased mutagenesis of HPRT1 gene; [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased abundance of 2-amino-1-methyl-6-phenolimidazo(4,5-b)pyridine-DNA adduct] which results in increased mutagenesis of HPRT1 gene; [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased abundance of N-(deoxyguanosin-8-yl)-2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased mutagenesis of HPRT1 gene; [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased mutagenesis of HPRT1 intron] which affects the splicing of HPRT1 mRNA

PMID:7728948 PMID:8625468 PMID:10728688 PMID:10987307 PMID:11289141 More...

NCBI chr X:132,736,175...132,768,149
Ensembl chr X:132,736,096...132,768,154

G

HRas proto-oncogene, GTPase

increases expression
increases mutagenesis
multiple interactions
affects response to substance

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of HRAS mRNA; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of HRAS protein
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased mutagenesis of HRAS gene
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased mutagenesis of and results in increased activity of HRAS; [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased abundance of 2-amino-1-methyl-6-phenolimidazo(4,5-b)pyridine-DNA adduct] which results in increased mutagenesis of HRAS gene; [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased mutagenesis of HRAS gene] which results in increased activity of HRAS protein; Dietary Fats affects the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased mutagenesis of HRAS gene]
HRAS protein affects the susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
HRAS protein affects the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased abundance of Reactive Oxygen Species]; HRAS protein affects the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of NOX1 protein]; HRAS protein affects the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased phosphorylation of MAPK1 protein]; HRAS protein affects the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased phosphorylation of MAPK3 protein]

PMID:8039140 PMID:9433479 PMID:11165753 PMID:12507937 PMID:15132766 More...

NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615

G

hydroxysteroid (17-beta) dehydrogenase 10

increases expression
decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of HSD17B10 mRNA
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of HSD17B10 mRNA

PMID:15215175 PMID:33945839

NCBI chr X:21,089,142...21,091,603
Ensembl chr X:21,089,122...21,109,488

G

heat shock protein 90 alpha family class A member 1

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of HSP90AA1 mRNA

NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268

G

heat shock protein 90 alpha family class B member 1

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of HSP90AB1 mRNA

NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488

G

heat shock protein family A (Hsp70) member 1A

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of HSPA1A mRNA

NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227

G

heat shock protein family A (Hsp70) member 2

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of HSPA2 mRNA

NCBI chr 6:95,128,504...95,131,281
Ensembl chr 6:95,128,350...95,131,287

G

heat shock protein family A (Hsp70) member 5

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of HSPA5 mRNA

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

heat shock protein family A (Hsp70) member 8

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of HSPA8 mRNA

NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259

G

heat shock protein family B (small) member 1

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of HSPB1 mRNA

NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743

G

heat shock protein family D (Hsp60) member 1

multiple interactions
increases expression

[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in decreased expression of HSPD1 mRNA; [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in increased expression of HSPD1 mRNA
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of HSPD1 mRNA

PMID:12097258 PMID:15215175

NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662

G

heat shock protein family E (Hsp10) member 1

multiple interactions
increases expression

[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in increased expression of HSPE1 mRNA
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of HSPE1 mRNA

PMID:12097258 PMID:15215175

NCBI chr 9:56,589,912...56,593,000
Ensembl chr 9:56,589,789...56,593,089

G

heat shock protein family H (Hsp110) member 1

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of HSPH1 mRNA

NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224

G

intercellular adhesion molecule 1

multiple interactions

[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in decreased expression of ICAM1 mRNA

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

inhibitor of DNA binding 2

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ID2 mRNA

NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400

G

inhibitor of DNA binding 3

decreases expression
increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of ID3 mRNA
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ID3 mRNA

PMID:12376462 PMID:15059925

NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349

G

inhibitor of DNA binding 4

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ID4 mRNA; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ID4 protein

NCBI chr17:16,389,387...16,391,956
Ensembl chr17:16,389,387...16,392,470

G

isocitrate dehydrogenase (NADP(+)) 1

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of IDH1 mRNA

NCBI chr 9:66,534,146...66,563,703
Ensembl chr 9:66,534,146...66,563,708

G

isocitrate dehydrogenase (NADP(+)) 2

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of IDH2 mRNA

NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025

G

indoleamine 2,3-dioxygenase 1

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of IDO1 mRNA

NCBI chr16:67,430,654...67,442,726
Ensembl chr16:67,430,578...67,442,730

G

interferon alpha and beta receptor subunit 2

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of IFNAR2 mRNA

NCBI chr11:30,613,576...30,645,958
Ensembl chr11:30,613,767...30,668,124

G

interferon gamma

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of IFNG mRNA

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

insulin-like growth factor binding protein 1

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of IGFBP1 mRNA

NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482

G

insulin-like growth factor binding protein 2

increases expression
decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of IGFBP2 mRNA
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of IGFBP2 mRNA

NCBI chr 9:74,415,574...74,442,945
Ensembl chr 9:74,415,546...74,442,937

G

interleukin 1 beta

decreases expression
increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of IL1B mRNA
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of IL1B mRNA

PMID:15059925 PMID:20702593

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 2

decreases secretion
decreases expression
multiple interactions

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased secretion of IL2 protein
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of IL2 mRNA
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL2 mRNA]; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of IL2 protein]

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 4 induced 1

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of IL4I1 mRNA

NCBI chr 1:95,299,457...95,324,564
Ensembl chr 1:95,295,601...95,324,562

G

interleukin 6

increases expression
multiple interactions

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of IL6 mRNA
[IL6 protein co-treated with 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] results in decreased expression of MIR27B mRNA; IL6 protein promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1B1 mRNA]

PMID:20702593 PMID:31515600

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

interleukin 6 cytokine family signal transducer

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of IL6ST mRNA; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of IL6ST protein

NCBI chr 2:44,065,979...44,106,255
Ensembl chr 2:44,066,130...44,109,936

G

inosine monophosphate dehydrogenase 2

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of IMPDH2 mRNA

NCBI chr 8:109,256,705...109,261,365
Ensembl chr 8:109,256,728...109,261,359

G

indolethylamine N-methyltransferase

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of INMT mRNA

NCBI chr 4:84,318,197...84,322,493
Ensembl chr 4:84,318,197...84,322,493

G

insulin 2

multiple interactions

[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with [Dexamethasone co-treated with INS protein co-treated with PRL protein]] results in decreased expression of BAX protein; [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with [Dexamethasone co-treated with INS protein co-treated with PRL protein]] results in increased activity of STAT5A protein; [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with [Dexamethasone co-treated with INS protein co-treated with PRL protein]] results in increased expression of BCL2 protein; [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with [Dexamethasone co-treated with INS protein co-treated with PRL protein]] results in increased expression of STAT5A protein modified form

NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775

G

insulin induced gene 1

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of INSIG1 mRNA

NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952

G

integrin subunit alpha 7

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of ITGA7 mRNA

NCBI chr 7:1,360,125...1,388,886
Ensembl chr 7:1,359,940...1,388,450

G

isovaleryl-CoA dehydrogenase

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of IVD mRNA

NCBI chr 3:105,851,710...105,872,144
Ensembl chr 3:105,851,683...105,872,575

G

Janus kinase 2

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of JAK2 mRNA

NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189

G

Jun proto-oncogene, AP-1 transcription factor subunit

increases expression
multiple interactions

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of JUN mRNA; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of JUN protein
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in increased expression of JUN mRNA

PMID:18283038 PMID:23313794

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

lysine acetyltransferase 6B

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of KAT6B mRNA

NCBI chr15:2,638,885...2,811,977
Ensembl chr15:2,639,200...2,812,316

G

potassium two pore domain channel subfamily K member 1

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of KCNK1 mRNA

NCBI chr19:53,959,411...53,997,726
Ensembl chr19:53,959,657...53,997,724

G

potassium channel tetramerization domain containing 2

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of KCTD2 mRNA

NCBI chr10:100,663,013...100,674,756
Ensembl chr10:100,662,884...100,674,336

G

lysine demethylase 1A

multiple interactions

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of and affects the localization of KDM1A protein; [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with 4-biphenylamine co-treated with Benzo(a)pyrene] affects the localization of KDM1A protein

NCBI chr 5:148,782,976...148,838,319
Ensembl chr 5:148,782,976...148,838,319

G

kinesin family member 20A

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of KIF20A mRNA

NCBI chr18:26,230,294...26,238,780
Ensembl chr18:26,230,230...26,238,780

G

KLF transcription factor 10

multiple interactions

[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in decreased expression of KLF10 mRNA

NCBI chr 7:69,467,658...69,473,726
Ensembl chr 7:69,465,619...69,473,994

G

kynurenine 3-monooxygenase

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of KMO mRNA

NCBI chr13:87,557,080...87,589,334
Ensembl chr13:87,557,286...87,588,881

G

keratin 19

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of KRT19 mRNA

NCBI chr10:85,075,835...85,080,552
Ensembl chr10:85,066,802...85,171,799

G

keratin 5

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of KRT5 mRNA

NCBI chr 7:132,846,132...132,851,861
Ensembl chr 7:132,846,136...132,851,850

G

kynurenine aminotransferase 3

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of KYAT3 mRNA

NCBI chr 2:231,701,881...231,747,462
Ensembl chr 2:231,701,963...231,747,227

G

kynureninase

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of KYNU mRNA

NCBI chr 3:27,778,646...27,929,470
Ensembl chr 3:27,778,772...27,929,488

G

lysosomal protein transmembrane 4 beta

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of LAPTM4B mRNA

NCBI chr 7:65,434,525...65,477,386
Ensembl chr 7:65,434,394...65,477,383

G

lipocalin 2

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of LCN2 mRNA

NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095

G

lin-7 homolog A, crumbs cell polarity complex component

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of LIN7A mRNA

NCBI chr 7:42,586,704...42,742,609
Ensembl chr 7:42,586,719...42,730,550

G

LIM domain only 4

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of LMO4 mRNA

NCBI chr 2:233,264,180...233,280,881
Ensembl chr 2:233,264,182...233,280,880

G

lysyl oxidase-like 2

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of LOXL2 mRNA

NCBI chr15:44,683,449...44,773,067
Ensembl chr15:44,683,880...44,773,067

G

lipoprotein lipase

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of LPL mRNA

PMID:12376462 PMID:15059925

NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249

G

LDL receptor related protein 1

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of LRP1 mRNA

NCBI chr 7:63,380,325...63,461,029
Ensembl chr 7:63,380,356...63,460,910

G

leucine-rich repeats and IQ motif containing 3

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of LRRIQ3 mRNA

NCBI chr 2:244,119,975...244,214,590
Ensembl chr 2:244,126,200...244,212,339

G

lipolysis stimulated lipoprotein receptor

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of LSR mRNA

NCBI chr 1:86,185,769...86,201,952
Ensembl chr 1:86,186,431...86,201,952

G

latent transforming growth factor beta binding protein 3

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of LTBP3 mRNA

NCBI chr 1:203,029,412...203,045,975
Ensembl chr 1:203,029,877...203,045,975

G

lumican

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of LUM mRNA

NCBI chr 7:32,358,990...32,365,794
Ensembl chr 7:32,358,614...32,365,793

G

mesencephalic astrocyte-derived neurotrophic factor

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MANF mRNA

NCBI chr 8:107,500,856...107,551,595
Ensembl chr 8:107,548,352...107,551,438

G

monoamine oxidase A

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of MAOA mRNA

NCBI chr X:6,032,172...6,098,308
Ensembl chr X:6,030,795...6,099,593

G

monoamine oxidase B

decreases expression
increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of MAOB mRNA
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MAOB mRNA

PMID:15059925 PMID:33945839

NCBI chr X:5,907,327...6,010,996
Ensembl chr X:5,907,266...6,011,003

G

mitogen activated protein kinase kinase 1

increases phosphorylation

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased phosphorylation of MAP2K1 protein

NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147

G

mitogen activated protein kinase kinase 2

increases phosphorylation

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased phosphorylation of MAP2K2 protein

NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243

G

mitogen activated protein kinase 1

multiple interactions
increases phosphorylation
increases expression

fulvestrant inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MAPK1 protein modified form]; HRAS protein affects the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased phosphorylation of MAPK1 protein]
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAPK1 protein]

PMID:15319301 PMID:18056474 PMID:18845389 PMID:22307971

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 14

affects expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine affects the expression of MAPK14 mRNA

NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589

G

mitogen activated protein kinase 3

increases phosphorylation
multiple interactions
increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased phosphorylation of MAPK3 protein
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAPK3 protein]
fulvestrant inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MAPK3 protein modified form]; HRAS protein affects the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased phosphorylation of MAPK3 protein]

PMID:15319301 PMID:18056474 PMID:18845389 PMID:22307971

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

microtubule-associated protein tau

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MAPT protein modified form

NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129

G

methionine adenosyltransferase 2A

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of MAT2A mRNA

NCBI chr 4:104,489,877...104,495,447
Ensembl chr 4:104,488,466...104,495,493

G

matrin 3

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MATR3 mRNA

NCBI chr18:27,154,098...27,193,212
Ensembl chr18:27,163,714...27,193,166

G

methylcrotonyl-CoA carboxylase subunit 1

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MCCC1 mRNA

NCBI chr 2:118,799,147...118,851,181
Ensembl chr 2:118,799,150...118,851,222

G

methylmalonyl CoA epimerase

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of MCEE mRNA

NCBI chr 1:117,964,576...117,987,779
Ensembl chr 1:117,964,576...117,988,484

G

minichromosome maintenance complex component 2

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MCM2 mRNA

NCBI chr 4:121,346,434...121,360,962
Ensembl chr 4:121,346,434...121,360,847

G

minichromosome maintenance complex component 6

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MCM6 mRNA

NCBI chr13:39,826,745...39,851,937
Ensembl chr13:39,826,763...39,851,960

G

minichromosome maintenance complex component 7

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MCM7 mRNA; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MCM7 protein

NCBI chr12:17,042,207...17,049,470
Ensembl chr12:17,042,212...17,050,063

G

minichromosome maintenance 8 homologous recombination repair factor

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MCM8 mRNA

NCBI chr 3:120,086,741...120,117,008
Ensembl chr 3:120,086,763...120,117,008

G

malate dehydrogenase 2

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MDH2 mRNA

NCBI chr12:20,894,269...20,907,225
Ensembl chr12:20,894,262...20,907,271

G

midkine

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MDK mRNA

NCBI chr 3:77,901,134...77,903,997
Ensembl chr 3:77,901,158...77,903,130

G

MDM2 proto-oncogene

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MDM2 protein

NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915

G

maternal embryonic leucine zipper kinase

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MELK mRNA

NCBI chr 5:58,540,393...58,600,562
Ensembl chr 5:58,540,449...58,600,937

G

meprin A subunit alpha

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of MEP1A mRNA

NCBI chr 9:17,474,634...17,504,147
Ensembl chr 9:17,474,619...17,504,147

G

milk fat globule EGF and factor V/VIII domain containing

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MFGE8 mRNA

NCBI chr 1:133,064,665...133,080,069
Ensembl chr 1:133,064,665...133,080,073

G

O-6-methylguanine-DNA methyltransferase

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MGMT mRNA

PMID:12706856 PMID:15215175 PMID:29877212

NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756

G

matrix Gla protein

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MGP mRNA

NCBI chr 4:169,766,290...169,769,612
Ensembl chr 4:169,766,279...169,769,667

G

microsomal glutathione S-transferase 1

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of MGST1 mRNA

NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892

G

microsomal glutathione S-transferase 2

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of MGST2 mRNA

NCBI chr 2:135,679,524...135,715,828
Ensembl chr 2:135,693,557...135,715,828

G

microsomal glutathione S-transferase 3

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of MGST3 mRNA

NCBI chr13:79,526,541...79,547,479
Ensembl chr13:79,526,541...79,547,411

G

macrophage migration inhibitory factor

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MIF mRNA

NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504
Ensembl chr 4:12,790,902...12,799,504

G

microRNA 106b

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of MIR106B mRNA

NCBI chr12:17,043,344...17,043,425
Ensembl chr12:17,043,344...17,043,425

G

microRNA 141

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of MIR141 mRNA

NCBI chr 4:157,523,239...157,523,332
Ensembl chr 4:157,523,239...157,523,332

G

microRNA 200c

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of MIR200C mRNA

NCBI chr 4:157,523,679...157,523,747

G

microRNA 21

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of MIR21 mRNA

NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348

G

microRNA 27b

multiple interactions

[IL6 protein co-treated with 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] results in decreased expression of MIR27B mRNA

NCBI chr17:1,813,427...1,813,523
Ensembl chr17:1,813,426...1,813,529

G

microRNA 30d

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of MIR30D mRNA

NCBI chr 7:100,136,391...100,136,472
Ensembl chr 7:100,136,391...100,136,472

G

microRNA 330

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of MIR330 mRNA

NCBI chr 1:78,833,178...78,833,274
Ensembl chr 1:78,833,178...78,833,274

G

microRNA 494

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MIR494 mRNA

NCBI chr 6:128,728,710...128,728,792
Ensembl chr 6:128,728,709...128,728,793

G

microRNA 615

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of MIR615 mRNA

NCBI chr 7:134,151,887...134,151,978
Ensembl chr 7:134,151,887...134,151,978

G

marker of proliferation Ki-67

decreases expression
increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of MKI67 protein
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MKI67 protein

PMID:23535288 PMID:29877212

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

MAPK interacting serine/threonine kinase 2

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MKNK2 mRNA

NCBI chr 7:9,039,771...9,050,832
Ensembl chr 7:9,039,728...9,050,827

G

mutL homolog 1

affects response to substance

MLH1 protein affects the susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine

PMID:11425520 PMID:16256150

NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617

G

malonyl-CoA decarboxylase

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of MLYCD mRNA

NCBI chr19:47,447,931...47,463,794
Ensembl chr19:47,447,970...47,463,793

G

matrix metallopeptidase 12

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MMP12 mRNA

NCBI chr 8:4,581,785...4,591,687
Ensembl chr 8:4,581,785...4,599,611

G

matrix metallopeptidase 2

multiple interactions
increases expression

U 0126 inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MMP2 protein]

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 7

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MMP7 mRNA

NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902

G

matrix metallopeptidase 9

increases secretion
increases expression
multiple interactions

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased secretion of MMP9 protein
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MMP9 protein
U 0126 inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MMP9 protein]

PMID:20951759 PMID:22307971

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

MORC family CW-type zinc finger 4

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of MORC4 mRNA

NCBI chr X:103,477,366...103,529,026
Ensembl chr X:103,480,603...103,528,956

G

mutS homolog 2

affects response to substance

MSH2 protein affects the susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine

PMID:11593414 PMID:12901791

NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938

G

mutS homolog 6

affects response to substance
increases expression

MSH6 protein affects the susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MSH6 protein

PMID:11425520 PMID:26091049

NCBI chr 6:6,562,631...6,579,995
Ensembl chr 6:6,562,632...6,579,956

G

mitochondrially encoded cytochrome c oxidase I

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of COX1 mRNA

NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867

G

mitochondrially encoded cytochrome b

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of CYTB mRNA

NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
Ensembl chr MT:14,136...15,278

G

metallothionein 1

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MT1 mRNA; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MT1A mRNA

PMID:15215175 PMID:29877212

NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049
Ensembl chr X:10,826,032...10,827,049

G

metallothionein 2A

increases expression
decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MT2A mRNA
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of MT2A mRNA

NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784

G

mutY DNA glycosylase

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MUTYH mRNA

NCBI chr 5:130,274,034...130,286,149
Ensembl chr 5:130,274,122...130,286,146

G

MYC proto-oncogene, bHLH transcription factor

increases expression
multiple interactions

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MYC protein
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MYC mRNA
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in increased expression of MYC mRNA; [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in increased expression of MYC protein; [Dietary Fats co-treated with 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] results in increased expression of MYC mRNA; Caffeine promotes the reaction [[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in increased expression of MYC mRNA]; Plant Preparations promotes the reaction [[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in increased expression of MYC mRNA]
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MYC protein alternative form

PMID:8603490 PMID:15059925 PMID:15319301 PMID:18283038 PMID:18616682 More...

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

myosin heavy chain 11

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MYH11 mRNA

NCBI chr10:743,364...838,459
Ensembl chr10:743,685...838,459

G

myosin light chain 6

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MYL6 mRNA

NCBI chr 7:910,764...914,062
Ensembl chr 7:910,774...933,791

G

Nedd4 binding protein 1

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of N4BP1 mRNA

NCBI chr19:20,222,811...20,273,570
Ensembl chr19:20,222,776...20,273,570

G

N-acetyltransferase 1

affects response to substance
increases expression

NAT1 protein affects the susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of NAT1 mRNA

PMID:18499698 PMID:31542801

NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520

G

N-acetyltransferase 2

increases activity
multiple interactions
affects activity
increases expression
decreases expression

NAT2 protein polymorphism results in increased activity of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine; NAT2 protein results in increased activity of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine affects the activity of NAT2 polymorphism] which affects the chemical synthesis of Glucose
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of NAT2 mRNA
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of NAT2 mRNA

PMID:15110095 PMID:22138251 PMID:29549414 PMID:37423373

NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520

G

N-acetyltransferase 8 (GCN5-related) family member 1

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of NAT8F1 mRNA

NCBI chr 4:118,336,208...118,342,923
Ensembl chr 4:118,332,862...118,344,035

G

N-acetyltransferase 8 (GCN5-related) family member 3

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of NAT8F3 mRNA

NCBI chr 4:118,241,792...118,246,010
Ensembl chr 4:118,239,304...118,285,500

G

neuron navigator 2

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of NAV2 mRNA

NCBI chr 1:98,957,629...99,322,339
Ensembl chr 1:98,663,759...99,322,337

G

necdin, MAGE family member

multiple interactions
increases methylation

[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased methylation of NDN promoter] which results in decreased expression of NDN mRNA

NCBI chr 1:115,849,168...115,850,767
Ensembl chr 1:115,849,105...115,850,767

G

NDRG family member 2

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of NDRG2 mRNA

NCBI chr15:24,600,981...24,609,621
Ensembl chr15:24,600,982...24,609,626

G

NADH:ubiquinone oxidoreductase subunit A2

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of NDUFA2 mRNA

NCBI chr18:28,355,774...28,357,863
Ensembl chr18:28,355,774...28,358,076

G

NIMA-related kinase 2

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of NEK2 mRNA

NCBI chr13:103,405,818...103,419,063
Ensembl chr13:103,405,819...103,419,051

G

NFE2 like bZIP transcription factor 2

increases expression
multiple interactions

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of NFE2L2 mRNA
[2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline co-treated with 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] results in increased expression of NFE2L2 mRNA

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NFE2 like bZIP transcription factor 3

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of NFE2L3 mRNA

NCBI chr 4:80,506,756...80,534,629
Ensembl chr 4:80,506,756...80,534,629

G

nuclear factor kappa B subunit 1

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of NFKB1

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

natural killer cell granule protein 7

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of NKG7 mRNA

NCBI chr 1:93,844,748...93,845,975
Ensembl chr 1:93,844,902...93,845,983

G

NME/NM23 family member 9

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of NME9 mRNA

NCBI chr 8:100,013,190...100,034,511

G

neuronatin

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of NNAT mRNA

NCBI chr 3:146,225,941...146,228,868
Ensembl chr 3:146,226,407...146,228,834

G

NOP10 ribonucleoprotein

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of NOP10 mRNA

NCBI chr 3:99,066,857...99,067,942
Ensembl chr 3:99,066,857...99,067,942

G

nitric oxide synthase 2

multiple interactions
increases expression

[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dextran Sulfate] results in increased expression of NOS2 protein
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of NOS2 protein

PMID:15459021 PMID:21081470

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

NADPH oxidase 1

increases expression
affects response to substance
multiple interactions

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of NOX1 protein
NOX1 protein affects the susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
[diphenyleneiodonium results in decreased activity of NOX1 protein] inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased abundance of Reactive Oxygen Species]; [diphenyleneiodonium results in decreased activity of NOX1 protein] which results in decreased susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine; HRAS protein affects the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of NOX1 protein]; NOX1 protein affects the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased abundance of Reactive Oxygen Species]; U 0126 inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of NOX1 protein]

PMID:20715105 PMID:22307971

NCBI chr X:97,279,058...97,332,291
Ensembl chr X:97,279,056...97,302,236

G

NADPH oxidase 4

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of NOX4

NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406

G

nucleophosmin 1

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of NPM1 mRNA

NCBI chr10:17,741,512...17,751,626
Ensembl chr10:17,739,941...17,751,645
Ensembl chr X:17,739,941...17,751,645

G

NMDA receptor synaptonuclear signaling and neuronal migration factor

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of NSMF mRNA

NCBI chr 3:7,861,846...7,870,615
Ensembl chr 3:7,861,872...7,870,614

G

neurotrophic receptor tyrosine kinase 1

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of NTRK1 mRNA

NCBI chr 2:173,236,961...173,253,806
Ensembl chr 2:173,236,963...173,253,770

G

NUMB, endocytic adaptor protein

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of NUMB mRNA

NCBI chr 6:103,431,400...103,553,422
Ensembl chr 6:103,431,400...103,553,354

G

nucleolar and spindle associated protein 1

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of NUSAP1 mRNA

NCBI chr 3:106,603,273...106,633,428
Ensembl chr 3:106,603,289...106,633,624

G

ornithine aminotransferase

multiple interactions

[CYP1A2 protein co-treated with POR protein co-treated with OAT protein] results in increased susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine

PMID:9581821 PMID:10503888

NCBI chr 1:187,347,862...187,367,644
Ensembl chr 1:187,347,865...187,367,682

G

outer dense fiber of sperm tails 4

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of ODF4 mRNA

NCBI chr10:53,628,592...53,634,525
Ensembl chr10:53,628,759...53,634,359

G

orosomucoid 1

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ORM1 protein

NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154

G

oncostatin M

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of OSM mRNA

NCBI chr14:79,103,638...79,108,500
Ensembl chr14:79,104,344...79,108,313

G

3-oxoacid CoA transferase 1

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of OXCT1 mRNA

NCBI chr 2:53,236,370...53,384,715
Ensembl chr 2:53,236,368...53,384,714

G

peptidyl arginine deiminase 4

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of PADI4 mRNA

NCBI chr 5:153,041,351...153,074,412
Ensembl chr 5:153,041,352...153,074,362

G

poly (A) polymerase alpha

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PAPOLA mRNA

NCBI chr 6:124,682,015...124,734,706
Ensembl chr 6:124,682,105...124,734,468

G

progestin and adipoQ receptor family member 7

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of PAQR7 mRNA

NCBI chr 5:146,709,159...146,720,577
Ensembl chr 5:146,708,900...146,720,673

G

PDZ binding kinase

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PBK mRNA

NCBI chr15:40,022,873...40,034,014
Ensembl chr15:40,023,002...40,034,014

G

poly(rC) binding protein 1

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PCBP1 mRNA

NCBI chr 4:118,972,698...118,974,705
Ensembl chr 4:118,972,661...118,976,500

G

propionyl-CoA carboxylase subunit alpha

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of PCCA mRNA

NCBI chr15:99,627,955...99,969,555
Ensembl chr15:99,627,982...99,968,266

G

phosphoenolpyruvate carboxykinase 1

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PCK1 mRNA

PMID:15215175 PMID:37005939

NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191

G

PCNA clamp associated factor

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PCLAF mRNA

NCBI chr 8:66,420,606...66,432,994
Ensembl chr 8:66,420,587...66,432,994
Ensembl chr 8:66,420,587...66,432,994

G

proliferating cell nuclear antigen

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PCNA mRNA

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

G

Purkinje cell protein 4

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of PCP4 mRNA

NCBI chr11:35,759,711...35,861,725
Ensembl chr11:35,800,713...35,861,725

G

programmed cell death 1

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of PDCD1 mRNA

NCBI chr 9:94,418,786...94,431,945
Ensembl chr 9:94,418,791...94,431,937

G

phosphodiesterase 10A

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PDE10A mRNA

NCBI chr 1:51,765,743...52,218,086
Ensembl chr 1:51,770,132...52,216,563

G

platelet derived growth factor subunit A

increases expression
increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PDGFA mRNA; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PDGFA protein
PhIP increases expression of Pdgfa mRNA and protein in rat mammary gland

CTD
RGD

PMID:12376462 PMID:15215175 PMID:12376462

NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497

G

protein disulfide isomerase family A, member 4

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PDIA4 mRNA

NCBI chr 4:76,803,198...76,822,245
Ensembl chr 4:76,803,198...76,822,107

G

PDZ domain containing 7

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PDZD7 mRNA

NCBI chr 1:243,888,295...243,907,778
Ensembl chr 1:243,888,281...243,906,839

G

phosphatidylethanolamine binding protein 1

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PEBP1 mRNA

NCBI chr12:39,302,864...39,307,064
Ensembl chr12:39,302,840...39,307,862

G

progesterone receptor

increases expression
multiple interactions

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PGR protein alternative form
fulvestrant inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PGR protein alternative form]
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PGR mRNA; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PGR protein

PMID:15319301 PMID:15637090

NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344

G

prohibitin 1

increases expression
increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PHB1 mRNA; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PHB1 protein
PhIP increases expression of Phb1 mRNA and protein in rat mammary gland

CTD
RGD

PMID:12376462 PMID:12376462

NCBI chr10:80,605,268...80,618,043
Ensembl chr10:80,605,251...80,618,042

G

phosphoglycerate dehydrogenase

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PHGDH mRNA

NCBI chr 2:185,906,962...185,936,054
Ensembl chr 2:185,906,966...185,935,944

G

phosphoinositide-3-kinase regulatory subunit 1

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PIK3R1 mRNA; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PIK3R1 protein

NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631

G

Pim-1 proto-oncogene, serine/threonine kinase

affects response to substance

PIM1 protein affects the susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine

NCBI chr20:7,554,921...7,559,174
Ensembl chr20:7,554,921...7,559,174

G

pyruvate kinase M1/2

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PKM mRNA

NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599

G

phospholipase C beta 1

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of PLCB1 mRNA

NCBI chr 3:122,059,988...122,772,896
Ensembl chr 3:122,060,031...122,772,869

G

polo-like kinase 2

increases expression
increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PLK2 mRNA
PhIP increases expression of Plk2 mRNA and protein in rat mammary gland

CTD
RGD

PMID:12376462 PMID:12376462

NCBI chr 2:41,969,176...41,974,945
Ensembl chr 2:41,969,176...41,974,947

G

DNA polymerase eta

affects activity

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine affects the activity of POLH protein

NCBI chr 9:14,778,355...14,813,210
Ensembl chr 9:14,777,888...14,812,723

G

DNA polymerase kappa

affects activity

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine affects the activity of POLK protein

NCBI chr 2:27,822,228...27,882,331
Ensembl chr 2:27,822,679...27,882,313

G

cytochrome p450 oxidoreductase

multiple interactions

[CYP1A2 protein co-treated with POR protein co-treated with OAT protein] results in increased susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine

PMID:9581821 PMID:10503888

NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245

G

POTE ankyrin domain family member D

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of POTED mRNA

NCBI chr17:57,942,124...57,975,149
Ensembl chr17:57,942,162...57,975,654

G

peroxisome proliferator activated receptor alpha

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PPARA mRNA

PMID:11137312 PMID:37005939

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

PPARG coactivator 1 alpha

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of PPARGC1A mRNA

NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656

G

peptidylprolyl isomerase C

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PPIC mRNA

NCBI chr18:46,842,410...46,855,016
Ensembl chr18:46,842,409...46,855,017

G

protein regulator of cytokinesis 1

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PRC1 mRNA

NCBI chr 1:134,250,086...134,271,765
Ensembl chr 1:134,250,081...134,271,765

G

proline rich mitotic checkpoint control factor

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PRCC mRNA

NCBI chr 2:173,326,261...173,351,799
Ensembl chr 2:173,326,259...173,351,825

G

peroxiredoxin 2

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PRDX2 mRNA

NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194

G

protein kinase cAMP-dependent type II regulatory subunit beta

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PRKAR2B mRNA

NCBI chr 6:48,563,659...48,653,933
Ensembl chr 6:48,563,662...48,653,933

G

prolactin

multiple interactions

[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with [Dexamethasone co-treated with INS protein co-treated with PRL protein]] results in decreased expression of BAX protein; [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with [Dexamethasone co-treated with INS protein co-treated with PRL protein]] results in increased activity of STAT5A protein; [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with [Dexamethasone co-treated with INS protein co-treated with PRL protein]] results in increased expression of BCL2 protein; [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with [Dexamethasone co-treated with INS protein co-treated with PRL protein]] results in increased expression of STAT5A protein modified form
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased secretion of PRL protein]; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of and results in increased secretion of PRL protein; Fulvestrant inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of and results in increased secretion of PRL protein]

PMID:11751460 PMID:17909072

NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062

G

phosphoserine aminotransferase 1

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of PSAT1 mRNA

NCBI chr 1:213,196,709...213,218,564
Ensembl chr 1:213,196,709...213,218,682

G

proteasome 20S subunit alpha 2

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PSMA2 mRNA

NCBI chr17:50,554,536...50,564,923
Ensembl chr17:50,551,924...50,564,938

G

proteasome 20S subunit alpha 6

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PSMA6 mRNA

NCBI chr 6:72,765,534...72,796,554
Ensembl chr 6:72,765,473...72,796,554

G

proteasome 20S subunit beta 1

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PSMB1 mRNA

NCBI chr 1:56,442,432...56,463,544
Ensembl chr 1:56,420,618...56,463,560

G

proteasome 20S subunit beta 2

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PSMB2 mRNA

NCBI chr 5:138,970,564...139,002,715
Ensembl chr 5:138,970,533...139,021,137

G

proteasome 20S subunit beta 4

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PSMB4 mRNA

NCBI chr 2:182,442,757...182,445,532
Ensembl chr 2:182,442,756...182,445,746

G

proteasome 20S subunit beta 6

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PSMB6 mRNA

NCBI chr10:55,239,256...55,241,586
Ensembl chr10:55,239,241...55,241,586

G

proteasome 20S subunit beta 9

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PSMB9 mRNA

NCBI chr20:4,667,044...4,672,512
Ensembl chr20:4,666,046...4,672,512

G

proteasome activator subunit 1

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PSME1 mRNA

NCBI chr15:29,069,012...29,071,888
Ensembl chr15:29,068,729...29,071,890

G

polypyrimidine tract binding protein 1

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PTBP1 mRNA

NCBI chr 7:9,842,574...9,852,332
Ensembl chr 7:9,842,574...9,852,397

G

phosphatase and tensin homolog

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of PTEN protein

NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838

G

prostaglandin E receptor 1

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PTGER1 mRNA

NCBI chr19:24,470,258...24,473,687
Ensembl chr19:24,467,532...24,473,559

G

prostaglandin E synthase 3

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PTGES3 mRNA

NCBI chr 7:490,698...507,759
Ensembl chr 7:490,656...508,084

G

prostaglandin-endoperoxide synthase 1

increases metabolic processing

PTGS1 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine

NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586

G

prostaglandin-endoperoxide synthase 2

increases metabolic processing
multiple interactions
increases expression

PTGS2 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dextran Sulfate] results in increased expression of PTGS2 protein
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PTGS2 protein
fulvestrant inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PTGS2 protein]

PMID:11159734 PMID:15459021 PMID:20951759 PMID:21081470

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

protein tyrosine phosphatase, receptor type, M

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of PTPRM mRNA

NCBI chr 9:106,639,573...107,343,698
Ensembl chr 9:106,639,573...107,343,698

G

QKI, KH domain containing RNA binding

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of QKI mRNA

NCBI chr 1:50,387,716...50,501,568
Ensembl chr 1:50,387,698...50,498,831

G

RAB11a, member RAS oncogene family

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RAB11A mRNA

NCBI chr 8:65,223,698...65,246,461
Ensembl chr 8:65,222,949...65,246,525

G

RAB1A, member RAS oncogene family

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RAB1A mRNA

NCBI chr14:94,422,219...94,448,799
Ensembl chr14:94,415,275...94,448,248

G

RAB1B, member RAS oncogene family

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RAB1B mRNA

NCBI chr 1:202,405,759...202,413,850
Ensembl chr 1:202,405,759...202,413,868
Ensembl chr X:202,405,759...202,413,868

G

RAB2A, member RAS oncogene family

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RAB2 mRNA

NCBI chr 5:21,676,017...21,740,035
Ensembl chr 5:21,676,129...21,739,899

G

Rac family small GTPase 2

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RAC2 mRNA

NCBI chr 7:110,101,344...110,128,718
Ensembl chr 7:110,116,260...110,128,720

G

Rac GTPase-activating protein 1

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RACGAP1 mRNA

NCBI chr 7:130,750,936...130,780,891
Ensembl chr 7:130,750,936...130,780,831

G

receptor for activated C kinase 1

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RACK1 mRNA

NCBI chr10:33,169,415...33,174,896
Ensembl chr10:33,169,169...33,174,975

G

RAD23 homolog B, nucleotide excision repair protein

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of RAD23B mRNA

NCBI chr 5:70,090,232...70,128,340
Ensembl chr 5:70,090,232...70,128,319

G

Raf-1 proto-oncogene, serine/threonine kinase

increases phosphorylation

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased phosphorylation of RAF1 protein

NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317

G

RAS like proto-oncogene B

increases expression
decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RALB mRNA
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of RALB mRNA

NCBI chr13:30,588,036...30,624,199
Ensembl chr13:30,588,033...30,624,202

G

RAN, member RAS oncogene family

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RAN mRNA

PMID:12376462 PMID:15215175

NCBI chr12:27,674,049...27,678,598
Ensembl chr12:27,674,050...27,678,276

G

Rap guanine nucleotide exchange factor 1

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of RAPGEF1 mRNA

NCBI chr 3:12,898,349...13,016,234
Ensembl chr 3:12,898,266...13,013,984

G

RAS p21 protein activator 1

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RASA1 mRNA; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RASA1 protein

NCBI chr 2:15,857,704...15,940,757
Ensembl chr 2:15,857,980...15,940,854

G

RAS protein-specific guanine nucleotide-releasing factor 2

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of RASGRF2 mRNA; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of RASGRF2 protein

NCBI chr 2:23,113,613...23,361,537
Ensembl chr 2:23,117,004...23,361,240

G

defensin RatNP-3 precursor

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RATNP-3B mRNA

NCBI chr16:70,544,364...70,546,533
Ensembl chr16:70,513,888...70,546,522

G

RB transcriptional corepressor 1

decreases phosphorylation
increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased phosphorylation of RB1 protein
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RB1 protein modified form

PMID:14522882 PMID:15635149

NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302

G

RB binding protein 4, chromatin remodeling factor

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RBBP4 mRNA

NCBI chr 5:141,655,863...141,675,157
Ensembl chr 5:141,638,421...141,675,284
Ensembl chr 2:141,638,421...141,675,284

G

RNA binding motif protein 14

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of RBM14 mRNA

NCBI chr 1:202,076,940...202,105,688
Ensembl chr 1:202,078,287...202,105,665
Ensembl chr 1:202,078,287...202,105,665

G

retinol binding protein 1

increases expression
increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RBP1 mRNA; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RBP1 protein
PhIP increases expression of Rbp1 mRNA and protein in rat mammary gland

CTD
RGD

PMID:12376462 PMID:12376462

NCBI chr 8:99,025,218...99,046,740
Ensembl chr 8:99,025,206...99,046,743

G

retinol binding protein 7

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RBP7 mRNA

NCBI chr 5:159,889,723...159,894,338
Ensembl chr 5:159,889,723...159,894,339

G

RELA proto-oncogene, NF-kB subunit

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RELA

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

ras homolog family member A

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of RHOA mRNA

NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746

G

ras homolog family member J

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of RHOJ mRNA

NCBI chr 6:94,035,307...94,117,642
Ensembl chr 6:94,035,483...94,118,275

G

regulating synaptic membrane exocytosis 4

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of RIMS4 mRNA

NCBI chr 3:152,520,982...152,585,070
Ensembl chr 3:152,524,095...152,584,780

G

Rho family GTPase 3

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RND3 mRNA

NCBI chr 3:35,571,929...35,589,283
Ensembl chr 3:35,571,143...35,589,327

G

ring finger protein 186

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of RNF186 mRNA

NCBI chr 5:151,210,492...151,211,716
Ensembl chr 5:151,210,492...151,211,716

G

ring finger protein 34

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of RNF34 mRNA

NCBI chr12:33,703,655...33,724,606
Ensembl chr12:33,703,673...33,724,586

G

retinitis pigmentosa GTPase regulator

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of RPGR mRNA

NCBI chr X:12,566,447...12,628,171
Ensembl chr X:12,566,645...12,747,882

G

RPGR interacting protein 1

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPGRIP1 mRNA

NCBI chr15:24,814,576...24,867,522
Ensembl chr15:24,814,614...24,868,605

G

ribosomal protein L10A

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPL10A mRNA

NCBI chr20:6,388,800...6,391,358
Ensembl chr20:6,385,823...6,391,357
Ensembl chr 9:6,385,823...6,391,357

G

ribosomal protein L12

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPL12 mRNA

NCBI chr 3:16,264,269...16,266,645
Ensembl chr 3:16,264,251...16,266,642

G

ribosomal protein L13

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPL13 mRNA

NCBI chr19:51,153,990...51,156,541
Ensembl chr19:51,153,924...51,163,014

G

ribosomal protein L13A

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPL13A mRNA

NCBI chr 1:95,609,374...95,612,557
Ensembl chr 1:95,609,370...95,620,463

G

ribosomal protein L19

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPL19 mRNA

NCBI chr10:83,022,503...83,026,030
Ensembl chr10:83,019,257...83,052,112

G

ribosomal protein L21

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPL21 mRNA

NCBI chr12:8,268,641...8,272,278
Ensembl chr12:8,267,196...8,272,281
Ensembl chr 3:8,267,196...8,272,281
Ensembl chr13:8,267,196...8,272,281

G

ribosomal protein L22

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPL22 mRNA

NCBI chr 5:162,835,241...162,843,394
Ensembl chr 5:162,833,740...162,843,368
Ensembl chr 7:162,833,740...162,843,368
Ensembl chr 4:162,833,740...162,843,368

G

ribosomal protein L26

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPL26 mRNA

NCBI chr10:53,610,836...53,613,966
Ensembl chr10:53,610,421...53,613,966

G

ribosomal protein L27A

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPL27A mRNA

NCBI chr 1:163,539,732...163,542,771

G

ribosomal protein L28

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPL28 mRNA

NCBI chr 1:69,052,148...69,054,735
Ensembl chr 1:69,053,203...69,055,032

G

ribosomal protein L3

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPL3 mRNA

NCBI chr 7:111,622,255...111,627,640
Ensembl chr 7:111,621,610...111,636,468

G

ribosomal protein L35

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPL35 mRNA

NCBI chr 3:22,753,255...22,756,217
Ensembl chr 3:22,753,253...22,756,243

G

ribosomal protein L35A

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPL35A mRNA

NCBI chr11:67,726,031...67,729,953
Ensembl chr11:67,726,032...67,729,942
Ensembl chr 5:67,726,032...67,729,942
Ensembl chr 6:67,726,032...67,729,942
Ensembl chr 7:67,726,032...67,729,942
Ensembl chr12:67,726,032...67,729,942

G

ribosomal protein L36

decreases expression
increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of RPL36 mRNA
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPL36 mRNA

NCBI chr 9:1,441,986...1,447,397
Ensembl chr 6:98,809,534...98,809,897
Ensembl chr 5:98,809,534...98,809,897

G

ribosomal protein L37A

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPL37A mRNA

NCBI chr 9:74,298,843...74,300,926

G

ribosomal protein L41

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPL41 mRNA

NCBI chr 7:977,885...978,965

G

ribosomal protein L6

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPL6 mRNA

PMID:12376462 PMID:15215175

NCBI chr12:35,347,493...35,352,011
Ensembl chr12:35,347,497...35,351,921

G

ribosomal protein L7

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPL7 mRNA

NCBI chr 5:3,217,184...3,220,192

G

ribosomal protein L8

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPL8 mRNA

NCBI chr 7:108,626,194...108,628,485
Ensembl chr 7:108,622,324...108,628,482
Ensembl chr 3:108,622,324...108,628,482

G

ribosomal protein lateral stalk subunit P0

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPLP0 mRNA

NCBI chr12:41,054,363...41,057,632
Ensembl chr12:41,054,179...41,057,632

G

ribosomal protein lateral stalk subunit P1

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPLP1 mRNA

NCBI chr 8:62,394,008...62,395,341
Ensembl chr 8:62,393,177...62,395,339

G

ribosomal protein lateral stalk subunit P2

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPLP2 mRNA

NCBI chr 1:196,546,086...196,548,636
Ensembl chr 1:196,546,352...196,548,645

G

ribosomal protein S11

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPS11 mRNA

NCBI chr 1:95,605,690...95,607,798
Ensembl chr 1:95,605,692...95,607,874

G

ribosomal protein S14

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPS14 mRNA

NCBI chr18:54,227,854...54,232,638
Ensembl chr18:54,227,854...54,233,166

G

ribosomal protein S15

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPS15 mRNA

NCBI chr 7:9,416,003...9,417,442
Ensembl chr 7:9,416,004...9,417,450
Ensembl chr 7:9,416,004...9,417,450

G

ribosomal protein S17

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPS17 mRNA

NCBI chr 1:135,295,920...135,298,506
Ensembl chr 1:135,295,919...135,298,535
Ensembl chr 8:135,295,919...135,298,535

G

ribosomal protein S19

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPS19 mRNA

NCBI chr 1:80,480,718...80,486,511
Ensembl chr 1:80,480,951...80,486,508
Ensembl chr 7:80,480,951...80,486,508

G

ribosomal protein S2

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPS2 mRNA

NCBI chr10:13,747,316...13,749,165
Ensembl chr10:13,747,301...13,749,163

G

ribosomal protein S23

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPS23 mRNA

NCBI chr 2:22,079,339...22,080,909
Ensembl chr 2:22,079,302...22,080,918

G

ribosomal protein S24

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPS24 mRNA

NCBI chr16:89,538...94,267
Ensembl chr16:89,604...94,279

G

ribosomal protein S29

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPS29 mRNA

NCBI chr 6:87,635,229...87,636,627
Ensembl chr 6:87,635,230...87,636,636
Ensembl chr13:87,635,230...87,636,636

G

ribosomal protein S3

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPS3 mRNA

NCBI chr 1:153,778,363...153,783,663
Ensembl chr 1:153,777,472...153,783,680

G

ribosomal protein S3a

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPS3A mRNA

NCBI chr 2:171,524,685...171,529,054
Ensembl chr 2:171,524,500...171,529,055

G

ribosomal protein S5

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPS5 mRNA

NCBI chr 1:73,538,776...73,543,073
Ensembl chr 1:73,538,776...73,543,073

G

ribosomal protein S6

multiple interactions
increases expression

[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in decreased expression of RPS6 mRNA; [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in increased expression of RPS6 mRNA
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPS6 mRNA

PMID:12097258 PMID:15215175

NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602

G

ribosomal protein S7

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPS7 mRNA

NCBI chr 6:45,266,200...45,271,064
Ensembl chr 6:45,223,980...45,271,145
Ensembl chr 5:45,223,980...45,271,145

G

ribosomal protein SA

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPSA mRNA

NCBI chr 8:119,851,225...119,855,103
Ensembl chr 8:119,851,225...119,855,247

G

ribonucleotide reductase regulatory subunit M2

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RRM2 mRNA

NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773

G

ribonucleotide reductase regulatory TP53 inducible subunit M2B

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RRM2B mRNA

NCBI chr 7:69,077,024...69,108,742
Ensembl chr 7:69,078,291...69,108,633

G

RT1 class II, locus Da

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of RT1-DA mRNA

NCBI chr20:4,513,464...4,518,457
Ensembl chr20:4,512,911...4,518,455

G

S100 calcium binding protein A1

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of S100A1 mRNA

NCBI chr 2:175,993,922...175,998,765
Ensembl chr 2:175,993,922...175,999,544

G

S100 calcium binding protein A9

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of S100A9 mRNA

NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230

G

sphingosine-1-phosphate receptor 1

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of S1PR1 mRNA

NCBI chr 2:203,624,752...203,629,110
Ensembl chr 2:203,621,587...203,629,681

G

scavenger receptor class B, member 1

decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of SCARB1 mRNA

NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647

G

stearoyl-CoA desaturase

increases expression
multiple interactions
decreases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of SCD mRNA; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of SCD1 mRNA
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in increased expression of SCD mRNA
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of SCD1 mRNA

PMID:12097258 PMID:12376462 PMID:15215175

NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562

G

stearoyl-Coenzyme A desaturase 2

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of SCD2 mRNA

NCBI chr 1:243,169,171...243,182,231
Ensembl chr 1:243,169,236...243,182,232

G

Sec61 translocon subunit gamma

increases expression

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of SEC61G mRNA

NCBI chr14:90,899,766...90,906,143
Ensembl chr14:90,899,768...90,906,162
Ensembl chr 9:90,899,768...90,906,162