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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:lipopeptide
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Accession:CHEBI:46895 term browser browse the term
Definition:A compound consisting of a peptide with attached lipid.
Synonyms:related_synonym: LP;   lipopeptides
 xref: pubmed:19889045;   pubmed:20545290;   pubmed:23131643;   pubmed:23318669;   wikipedia.en:Lipopeptide


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caspofungin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hnmt histamine N-methyltransferase decreases activity ISO caspofungin results in decreased activity of HNMT protein CTD PMID:12921242 NCBI chr 3:26,978,274...27,010,291
Ensembl chr 3:26,977,933...27,010,482 		JBrowse link
colistin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
decreases expression
multiple interactions 		EXP
ISO 		Colistin results in decreased phosphorylation of AKT1 protein
Colistin results in decreased expression of AKT1 protein modified form
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rhodioloside inhibits the reaction [Colistin results in decreased phosphorylation of AKT1 protein]]; rhodioloside inhibits the reaction [Colistin results in decreased phosphorylation of AKT1 protein] 		CTD PMID:28465020 PMID:35378205 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression ISO Colistin results in increased expression of APAF1 mRNA; Colistin results in increased expression of APAF1 protein CTD PMID:34560125 NCBI chr 7:27,381,392...27,466,772
Ensembl chr 7:27,381,855...27,466,772 		JBrowse link
G Atg12 autophagy related 12 increases expression ISO Colistin results in increased expression of ATG12 mRNA CTD PMID:35378205 NCBI chr18:41,638,841...41,649,311
Ensembl chr18:41,635,835...41,649,261 		JBrowse link
G Atg5 autophagy related 5 increases expression ISO Colistin results in increased expression of ATG5 mRNA CTD PMID:35378205 NCBI chr20:49,380,835...49,471,826
Ensembl chr20:49,380,813...49,471,821 		JBrowse link
G Atg9a autophagy related 9A increases expression ISO Colistin results in increased expression of ATG9A mRNA CTD PMID:35378205 NCBI chr 9:84,126,071...84,136,723
Ensembl chr 9:84,126,071...84,136,666 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression 		EXP
ISO 		2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rhodioloside inhibits the reaction [Colistin results in increased expression of BAX protein]]; rhodioloside inhibits the reaction [Colistin results in increased expression of BAX protein]
Colistin results in increased expression of BAX mRNA; Colistin results in increased expression of BAX protein 		CTD PMID:28465020 PMID:28842171 PMID:34560125 PMID:35378205 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
increases phosphorylation 		EXP
ISO 		Colistin results in decreased expression of BCL2 protein
Sirolimus inhibits the reaction [Colistin results in decreased expression of BCL2 protein]
Colistin results in decreased expression of BCL2 mRNA; Colistin results in decreased expression of BCL2 protein
Colistin results in increased phosphorylation of BCL2 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rhodioloside inhibits the reaction [Colistin results in decreased expression of BCL2 protein]]; [Colistin co-treated with Anisomycin] results in increased phosphorylation of BCL2 protein; Curcumin inhibits the reaction [Colistin results in decreased expression of BCL2 protein]; rhodioloside inhibits the reaction [Colistin results in decreased expression of BCL2 protein] 		CTD PMID:28465020 PMID:28842171 PMID:30138604 PMID:34560125 PMID:35378205 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
decreases expression 		ISO Sirolimus inhibits the reaction [Colistin results in decreased expression of BCL2L1 protein] CTD PMID:35378205 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907 		JBrowse link
G Becn1 beclin 1 increases expression
multiple interactions 		EXP
ISO 		Colistin results in increased expression of BECN1 mRNA; Colistin results in increased expression of BECN1 protein
Anisomycin promotes the reaction [Colistin results in increased expression of BECN1 protein]; dapagliflozin inhibits the reaction [Colistin results in increased expression of BECN1 protein]; NGF protein inhibits the reaction [Colistin results in increased expression of BECN1 mRNA]; NGF protein inhibits the reaction [Colistin results in increased expression of BECN1 protein]; pyrazolanthrone inhibits the reaction [Colistin results in increased expression of BECN1 protein]; taxifolin inhibits the reaction [Colistin results in increased expression of BECN1 protein]; taxifolin promotes the reaction [dapagliflozin inhibits the reaction [Colistin results in increased expression of BECN1 protein]] 		CTD PMID:28842171 PMID:30318960 PMID:33882723 PMID:35378205 NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,731,650...86,747,002 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases expression
increases cleavage 		EXP
ISO 		2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rhodioloside inhibits the reaction [Colistin results in increased activity of and results in increased cleavage of CASP3 protein]]; [Colistin co-treated with Anisomycin] results in increased cleavage of CASP3 protein; [colistinmethanesulfonic acid results in increased abundance of Colistin] which results in increased expression of CASP3 protein; chrysin inhibits the reaction [Colistin results in increased expression of CASP3 protein]; Colistin results in increased activity of and results in increased cleavage of CASP3 protein; Curcumin inhibits the reaction [Colistin results in increased expression of CASP3 protein]; dapagliflozin inhibits the reaction [Colistin results in increased activity of CASP3 protein]; NGF protein inhibits the reaction [Colistin results in increased expression of CASP3 mRNA]; NGF protein inhibits the reaction [Colistin results in increased expression of CASP3 protein]; rhodioloside inhibits the reaction [Colistin results in increased activity of and results in increased cleavage of CASP3 protein]; taxifolin inhibits the reaction [Colistin results in increased activity of CASP3 protein]; taxifolin promotes the reaction [dapagliflozin inhibits the reaction [Colistin results in increased activity of CASP3 protein]]; Thioctic Acid inhibits the reaction [[colistinmethanesulfonic acid results in increased abundance of Colistin] which results in increased expression of CASP3 mRNA]
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Colistin results in increased activity of CASP3 protein]; MitoTEMPO inhibits the reaction [Colistin results in increased activity of CASP3 protein]; setanaxib inhibits the reaction [Colistin results in increased activity of CASP3 protein]; Sirolimus inhibits the reaction [Colistin results in increased activity of CASP3 protein]
Colistin results in increased cleavage of CASP3 protein
Colistin results in increased expression of CASP3 mRNA; Colistin results in increased expression of CASP3 protein 		CTD PMID:28465020 PMID:28842171 PMID:30138604 PMID:30273961 PMID:30318960 More... NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp8 caspase 8 increases cleavage ISO Colistin results in increased cleavage of CASP8 protein CTD PMID:34560125 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699 		JBrowse link
G Casp9 caspase 9 increases expression
increases activity
multiple interactions
increases cleavage 		ISO Colistin results in increased expression of CASP9 mRNA
Colistin results in increased activity of CASP9 protein
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Colistin results in increased activity of CASP9 protein]; MitoTEMPO inhibits the reaction [Colistin results in increased activity of CASP9 protein]; setanaxib inhibits the reaction [Colistin results in increased activity of CASP9 protein]; Sirolimus inhibits the reaction [Colistin results in increased activity of CASP9 protein]
Colistin results in increased cleavage of CASP9 protein 		CTD PMID:34560125 PMID:35378205 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cat catalase decreases expression
decreases activity
multiple interactions 		EXP
ISO 		Colistin results in decreased expression of CAT protein
Colistin results in decreased activity of CAT protein
chrysin inhibits the reaction [Colistin results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Colistin results in decreased expression of CAT protein] 		CTD PMID:30138604 PMID:30273961 PMID:35378205 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions EXP [colistinmethanesulfonic acid results in increased abundance of Colistin] which results in increased expression of CYBA mRNA; Thioctic Acid inhibits the reaction [[colistinmethanesulfonic acid results in increased abundance of Colistin] which results in increased expression of CYBA mRNA] CTD PMID:33111558 NCBI chr19:67,396,143...67,404,214
Ensembl chr19:67,396,143...67,404,214 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions
increases expression 		EXP [taxifolin co-treated with dapagliflozin] inhibits the reaction [Colistin results in increased expression of CYCS protein]; dapagliflozin inhibits the reaction [Colistin results in increased expression of CYCS protein]; taxifolin inhibits the reaction [Colistin results in increased expression of CYCS protein] CTD PMID:33882723 NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816 		JBrowse link
G Dgcr8 DGCR8 microprocessor complex subunit decreases expression ISO Colistin results in decreased expression of DGCR8 protein CTD PMID:34560125 NCBI chr11:96,208,959...96,241,560
Ensembl chr11:96,209,038...96,241,551 		JBrowse link
G Gsr glutathione-disulfide reductase decreases expression
multiple interactions 		EXP Colistin results in decreased expression of GSR protein
dapagliflozin inhibits the reaction [Colistin results in decreased expression of GSR protein]; taxifolin inhibits the reaction [Colistin results in decreased expression of GSR protein]; taxifolin promotes the reaction [dapagliflozin inhibits the reaction [Colistin results in decreased expression of GSR protein]] 		CTD PMID:33882723 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions EXP [colistinmethanesulfonic acid results in increased abundance of Colistin] which results in increased expression of HAVCR1 mRNA; [colistinmethanesulfonic acid results in increased abundance of Colistin] which results in increased expression of HAVCR1 protein; Thioctic Acid inhibits the reaction [[colistinmethanesulfonic acid results in increased abundance of Colistin] which results in increased expression of HAVCR1 mRNA]; Thioctic Acid inhibits the reaction [[colistinmethanesulfonic acid results in increased abundance of Colistin] which results in increased expression of HAVCR1 protein] CTD PMID:33111558 NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,619,897...31,653,268 		JBrowse link
G Hmox1 heme oxygenase 1 decreases expression ISO Colistin results in decreased expression of HMOX1 mRNA; Colistin results in decreased expression of HMOX1 protein CTD PMID:34560125 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Il15 interleukin 15 increases expression
multiple interactions 		EXP Colistin results in increased expression of IL15 protein
dapagliflozin inhibits the reaction [Colistin results in increased expression of IL15 protein]; taxifolin inhibits the reaction [Colistin results in increased expression of IL15 protein]; taxifolin promotes the reaction [dapagliflozin inhibits the reaction [Colistin results in increased expression of IL15 protein]] 		CTD PMID:33882723 NCBI chr19:42,536,160...42,611,349
Ensembl chr19:42,545,346...42,611,348 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression 		EXP Curcumin inhibits the reaction [Colistin results in increased expression of IL6 protein] CTD PMID:30138604 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 increases expression ISO Colistin results in increased expression of KEAP1 mRNA; Colistin results in increased expression of KEAP1 protein CTD PMID:34560125 NCBI chr 8:28,044,555...28,054,042
Ensembl chr 8:28,044,555...28,054,042 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases expression 		EXP chrysin inhibits the reaction [Colistin results in increased expression of MAP1LC3B protein]; NGF protein inhibits the reaction [Colistin results in increased expression of MAP1LC3B mRNA]; NGF protein inhibits the reaction [Colistin results in increased expression of MAP1LC3B protein]
Colistin results in increased expression of MAP1LC3B mRNA; Colistin results in increased expression of MAP1LC3B protein 		CTD PMID:30273961 PMID:30318960 NCBI chr19:66,571,631...66,582,270
Ensembl chr19:66,574,407...66,584,358
Ensembl chr16:66,574,407...66,584,358 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases activity
multiple interactions 		EXP Colistin results in increased activity of MAPK8 protein
dapagliflozin inhibits the reaction [Colistin results in increased activity of MAPK8 protein]; taxifolin inhibits the reaction [Colistin results in increased activity of MAPK8 protein] 		CTD PMID:33882723 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427 		JBrowse link
G Mettl3 methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit decreases expression ISO Colistin results in decreased expression of METTL3 mRNA; Colistin results in decreased expression of METTL3 protein CTD PMID:34560125 NCBI chr15:27,476,659...27,491,134
Ensembl chr15:27,476,660...27,487,487 		JBrowse link
G Mrgprx2 MAS related GPR family member X2 multiple interactions
increases response to substance 		ISO MRGPRX2 protein affects the reaction [Colistin results in increased secretion of OGA protein]
MRGPRX2 protein results in increased susceptibility to Colistin 		CTD PMID:31132327 NCBI chr 1:107,252,467...107,271,809 JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases expression ISO Colistin results in decreased expression of MTOR protein modified form CTD PMID:35378205 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435 		JBrowse link
G Ndufb8 NADH:ubiquinone oxidoreductase subunit B8 decreases expression ISO Colistin results in decreased expression of NDUFB8 protein CTD PMID:35378205 NCBI chr 1:253,357,878...253,362,936
Ensembl chr 1:253,357,841...253,362,936 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 decreases expression
multiple interactions 		ISO
EXP 		Colistin results in decreased expression of NFE2L2 protein
dapagliflozin inhibits the reaction [Colistin results in decreased expression of NFE2L2 protein]; taxifolin inhibits the reaction [Colistin results in decreased expression of NFE2L2 protein]; taxifolin promotes the reaction [dapagliflozin inhibits the reaction [Colistin results in decreased expression of NFE2L2 protein]] 		CTD PMID:33882723 PMID:34560125 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Ngf nerve growth factor multiple interactions
decreases expression 		EXP dapagliflozin inhibits the reaction [Colistin results in decreased expression of NGF protein]; NGF protein inhibits the reaction [Colistin results in increased expression of BECN1 mRNA]; NGF protein inhibits the reaction [Colistin results in increased expression of BECN1 protein]; NGF protein inhibits the reaction [Colistin results in increased expression of CASP3 mRNA]; NGF protein inhibits the reaction [Colistin results in increased expression of CASP3 protein]; NGF protein inhibits the reaction [Colistin results in increased expression of MAP1LC3B mRNA]; NGF protein inhibits the reaction [Colistin results in increased expression of MAP1LC3B protein]; taxifolin inhibits the reaction [Colistin results in decreased expression of NGF protein]; taxifolin promotes the reaction [dapagliflozin inhibits the reaction [Colistin results in decreased expression of NGF protein]] CTD PMID:30318960 PMID:33882723 NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:192,589,582...192,643,834 		JBrowse link
G Nox4 NADPH oxidase 4 increases expression
multiple interactions 		ISO
EXP 		Colistin results in increased expression of NOX4 mRNA; Colistin results in increased expression of NOX4 protein
[colistinmethanesulfonic acid results in increased abundance of Colistin] which results in increased expression of NOX4 mRNA; Thioctic Acid inhibits the reaction [[colistinmethanesulfonic acid results in increased abundance of Colistin] which results in increased expression of NOX4 mRNA] 		CTD PMID:33111558 PMID:35378205 NCBI chr 1:150,313,736...150,491,480
Ensembl chr 1:150,313,728...150,491,483 		JBrowse link
G Oga O-GlcNAcase increases secretion
increases activity
multiple interactions 		ISO
EXP 		Colistin results in increased secretion of OGA protein
Colistin results in increased activity of OGA protein
[taxifolin co-treated with dapagliflozin] inhibits the reaction [Colistin results in increased activity of OGA protein]; dapagliflozin inhibits the reaction [Colistin results in increased activity of OGA protein]; taxifolin inhibits the reaction [Colistin results in increased activity of OGA protein]
MRGPRX2 protein affects the reaction [Colistin results in increased secretion of OGA protein] 		CTD PMID:31132327 PMID:33882723 NCBI chr 1:254,547,311...254,589,596
Ensembl chr 1:254,547,311...254,582,855 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions EXP [Colistin co-treated with Anisomycin] results in increased cleavage of PARP1 protein CTD PMID:28842171 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases expression 		EXP dapagliflozin inhibits the reaction [Colistin results in increased expression of RELA protein]; taxifolin inhibits the reaction [Colistin results in increased expression of RELA protein]; taxifolin promotes the reaction [dapagliflozin inhibits the reaction [Colistin results in increased expression of RELA protein]] CTD PMID:33882723 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Sdhb succinate dehydrogenase complex iron sulfur subunit B decreases expression ISO Colistin results in decreased expression of SDHB protein CTD PMID:35378205 NCBI chr 5:158,547,775...158,568,589
Ensembl chr 5:158,547,689...158,569,667 		JBrowse link
G Sqstm1 sequestosome 1 increases degradation
multiple interactions 		EXP Colistin results in increased degradation of SQSTM1 protein
Anisomycin promotes the reaction [Colistin results in increased degradation of SQSTM1 protein]; pyrazolanthrone inhibits the reaction [Colistin results in increased degradation of SQSTM1 protein] 		CTD PMID:28842171 NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
decreases expression 		EXP dapagliflozin inhibits the reaction [Colistin results in decreased expression of STAT3 protein]; taxifolin inhibits the reaction [Colistin results in decreased expression of STAT3 protein]; taxifolin promotes the reaction [dapagliflozin inhibits the reaction [Colistin results in decreased expression of STAT3 protein]] CTD PMID:33882723 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression
multiple interactions 		ISO
EXP 		Colistin results in increased expression of TGFB1 mRNA; Colistin results in increased expression of TGFB1 protein
dapagliflozin inhibits the reaction [Colistin results in increased expression of TGFB1 protein]; taxifolin inhibits the reaction [Colistin results in increased expression of TGFB1 protein]; taxifolin promotes the reaction [dapagliflozin inhibits the reaction [Colistin results in increased expression of TGFB1 protein]] 		CTD PMID:33882723 PMID:35378205 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Tlr4 toll-like receptor 4 increases expression
multiple interactions 		EXP Colistin results in increased expression of TLR4 protein
dapagliflozin inhibits the reaction [Colistin results in increased expression of TLR4 protein]; taxifolin inhibits the reaction [Colistin results in increased expression of TLR4 protein]; taxifolin promotes the reaction [dapagliflozin inhibits the reaction [Colistin results in increased expression of TLR4 protein]] 		CTD PMID:33882723 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007 		JBrowse link
G Tnf tumor necrosis factor increases expression
increases secretion
multiple interactions 		EXP
ISO 		Colistin results in increased expression of TNF protein
Colistin results in increased secretion of TNF protein
[colistinmethanesulfonic acid results in increased abundance of Colistin] which results in increased expression of TNF protein; Curcumin inhibits the reaction [Colistin results in increased expression of TNF protein]; dapagliflozin inhibits the reaction [Colistin results in increased expression of TNF protein]; taxifolin inhibits the reaction [Colistin results in increased expression of TNF protein]; taxifolin promotes the reaction [dapagliflozin inhibits the reaction [Colistin results in increased expression of TNF protein]] 		CTD PMID:30138604 PMID:31132327 PMID:33111558 PMID:33882723 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression 		EXP Anisomycin promotes the reaction [Colistin results in increased expression of TP53 protein]; pyrazolanthrone inhibits the reaction [Colistin results in increased expression of TP53 protein] CTD PMID:28842171 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
G Tsc2 TSC complex subunit 2 increases expression ISO Colistin results in increased expression of TSC2 protein CTD PMID:35378205 NCBI chr10:14,125,679...14,160,317
Ensembl chr10:14,125,680...14,160,600 		JBrowse link
G Uqcrc2 ubiquinol cytochrome c reductase core protein 2 decreases expression ISO Colistin results in decreased expression of UQCRC2 protein CTD PMID:35378205 NCBI chr 1:184,599,240...184,629,804
Ensembl chr 1:184,599,212...184,630,946 		JBrowse link
liraglutide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha multiple interactions ISO Liraglutide inhibits the reaction [Dietary Fats results in increased expression of ACACA mRNA]; Liraglutide inhibits the reaction [IL1B protein results in increased phosphorylation of ACACA protein] CTD PMID:32898504 PMID:35565866 NCBI chr10:69,511,627...69,773,888
Ensembl chr10:69,511,857...69,773,888 		JBrowse link
G Adam33 ADAM metallopeptidase domain 33 decreases methylation
increases expression 		ISO Liraglutide results in decreased methylation of ADAM33 promoter
Liraglutide results in increased expression of ADAM33 mRNA; Liraglutide results in increased expression of ADAM33 protein 		CTD PMID:34534549 NCBI chr 3:138,715,428...138,736,392
Ensembl chr 3:138,724,046...138,736,347 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO Liraglutide inhibits the reaction [IL1B protein results in decreased secretion of ADIPOQ protein] CTD PMID:32898504 NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO Liraglutide inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Liraglutide inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein]] CTD PMID:31173752 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Azgp1 alpha-2-glycoprotein 1, zinc-binding multiple interactions
increases expression 		ISO Liraglutide inhibits the reaction [Dietary Fats results in decreased secretion of AZGP1 protein]
Liraglutide results in increased expression of AZGP1 mRNA 		CTD PMID:35565866 NCBI chr12:22,044,685...22,051,248
Ensembl chr12:22,044,751...22,053,020 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO
EXP 		Liraglutide inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]; Wortmannin inhibits the reaction [Liraglutide inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]]
Liraglutide inhibits the reaction [Methotrexate results in increased expression of BAX protein] 		CTD PMID:31173752 PMID:31362085 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO
EXP 		Liraglutide inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein]; Wortmannin inhibits the reaction [Liraglutide inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein]]
Liraglutide inhibits the reaction [Methotrexate results in decreased expression of BCL2 protein] 		CTD PMID:31173752 PMID:31362085 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP 		Liraglutide inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein]; Wortmannin inhibits the reaction [Liraglutide inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein]]
Liraglutide inhibits the reaction [Methotrexate results in increased expression of and results in increased activity of CASP3 protein] 		CTD PMID:31173752 PMID:31362085 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Cdh1 cadherin 1 increases expression
decreases methylation 		ISO Liraglutide results in increased expression of CDH1 mRNA; Liraglutide results in increased expression of CDH1 protein
Liraglutide results in decreased methylation of CDH1 promoter 		CTD PMID:34534549 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions
increases expression 		ISO Liraglutide inhibits the reaction [IL1B protein results in decreased expression of CPT1A protein]
Liraglutide results in increased expression of CPT1A mRNA 		CTD PMID:32898504 PMID:35565866 NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:209,993,875...210,056,326 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP Liraglutide inhibits the reaction [Methotrexate results in decreased phosphorylation of CREB1 protein] CTD PMID:31362085 NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339 		JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions ISO Liraglutide inhibits the reaction [Pyruvaldehyde results in increased expression of CYBA mRNA] CTD PMID:35985417 NCBI chr19:67,396,143...67,404,214
Ensembl chr19:67,396,143...67,404,214 		JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions ISO Liraglutide inhibits the reaction [Pyruvaldehyde results in increased expression of CYBB mRNA] CTD PMID:35985417 NCBI chr  X:16,030,596...16,065,065
Ensembl chr  X:16,030,596...16,065,065 		JBrowse link
G Dgat1 diacylglycerol O-acyltransferase 1 multiple interactions ISO Liraglutide inhibits the reaction [IL1B protein results in decreased expression of DGAT1 protein] CTD PMID:32898504 NCBI chr 7:110,104,514...110,119,091
Ensembl chr 7:110,098,906...110,115,016 		JBrowse link
G Esr1 estrogen receptor 1 increases expression ISO Liraglutide results in increased expression of ESR1 mRNA; Liraglutide results in increased expression of ESR1 protein CTD PMID:34534549 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354 		JBrowse link
G Fasn fatty acid synthase multiple interactions ISO Liraglutide inhibits the reaction [Dietary Fats results in increased expression of FASN mRNA] CTD PMID:35565866 NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583 		JBrowse link
G Fgf21 fibroblast growth factor 21 multiple interactions ISO Liraglutide inhibits the reaction [Dietary Fats results in decreased secretion of FGF21 protein] CTD PMID:35565866 NCBI chr 1:105,219,825...105,221,376
Ensembl chr 1:105,219,825...105,232,056 		JBrowse link
G Glp1r glucagon-like peptide 1 receptor multiple interactions
increases activity
increases expression 		EXP
ISO 		Liraglutide inhibits the reaction [nitrofen results in decreased expression of GLP1R mRNA]
Liraglutide results in increased activity of GLP1R protein
[Liraglutide results in increased activity of GLP1R protein] which results in increased abundance of Cyclic AMP
Liraglutide binds to and results in increased activity of GLP1R protein
Liraglutide results in increased expression of GLP1R mRNA 		CTD PMID:23354098 PMID:23471186 PMID:35985417 PMID:39395609 NCBI chr20:8,973,393...9,011,622
Ensembl chr20:8,973,352...9,011,654 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP Liraglutide inhibits the reaction [Methotrexate results in increased expression of GPT protein] CTD PMID:31362085 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO Liraglutide inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of GSK3B protein]; Wortmannin inhibits the reaction [Liraglutide inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of GSK3B protein]] CTD PMID:31173752 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP Liraglutide inhibits the reaction [Methotrexate results in increased expression of HMOX1 protein] CTD PMID:31362085 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Liraglutide inhibits the reaction [IL1B protein results in decreased expression of CPT1A protein]; Liraglutide inhibits the reaction [IL1B protein results in decreased expression of DGAT1 protein]; Liraglutide inhibits the reaction [IL1B protein results in decreased expression of PPARGC1A protein]; Liraglutide inhibits the reaction [IL1B protein results in decreased secretion of ADIPOQ protein]; Liraglutide inhibits the reaction [IL1B protein results in increased expression of NOX4 mRNA]; Liraglutide inhibits the reaction [IL1B protein results in increased expression of NOX4 protein]; Liraglutide inhibits the reaction [IL1B protein results in increased phosphorylation of ACACA protein] CTD PMID:32898504 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP Liraglutide inhibits the reaction [Methotrexate results in increased expression of IL6 protein] CTD PMID:31362085 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Lipe lipase E, hormone sensitive type increases expression ISO Liraglutide results in increased expression of LIPE mRNA CTD PMID:35565866 NCBI chr 1:90,093,433...90,112,117
Ensembl chr 1:90,093,433...90,112,117 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO Liraglutide inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPT protein]; Wortmannin inhibits the reaction [Liraglutide inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPT protein]] CTD PMID:31173752 NCBI chr10:89,638,618...89,736,108
Ensembl chr10:89,638,599...89,736,108 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP Liraglutide inhibits the reaction [Methotrexate results in decreased expression of NFE2L2 protein] CTD PMID:31362085 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions ISO Liraglutide inhibits the reaction [IL1B protein results in increased expression of NOX4 mRNA]; Liraglutide inhibits the reaction [IL1B protein results in increased expression of NOX4 protein] CTD PMID:32898504 NCBI chr 1:150,313,736...150,491,480
Ensembl chr 1:150,313,728...150,491,483 		JBrowse link
G Pnpla2 patatin-like phospholipase domain containing 2 increases expression ISO Liraglutide results in increased expression of PNPLA2 mRNA CTD PMID:35565866 NCBI chr 1:205,982,279...205,987,361
Ensembl chr 1:205,982,258...205,987,359 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO Liraglutide inhibits the reaction [IL1B protein results in decreased expression of PPARGC1A protein] CTD PMID:32898504 NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Liraglutide inhibits the reaction [Methotrexate results in increased expression of PTGS2 protein] CTD PMID:31362085 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Liraglutide inhibits the reaction [Methotrexate results in increased expression of RELA protein] CTD PMID:31362085 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Sftpa1 surfactant protein A1 increases expression
multiple interactions 		EXP Liraglutide results in increased expression of SFTPA1 mRNA
Liraglutide inhibits the reaction [nitrofen results in decreased expression of SFTPA1 mRNA]; Liraglutide inhibits the reaction [nitrofen results in decreased expression of SFTPA1 protein] 		CTD PMID:23354098 NCBI chr16:17,042,264...17,045,770
Ensembl chr16:17,042,255...17,045,769 		JBrowse link
G Sftpb surfactant protein B increases expression EXP Liraglutide results in increased expression of SFTPB mRNA CTD PMID:23354098 NCBI chr 4:105,917,495...105,926,631
Ensembl chr 4:105,917,578...105,927,646 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO Liraglutide inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA] CTD PMID:35565866 NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Liraglutide inhibits the reaction [Methotrexate results in increased expression of TNF protein] CTD PMID:31362085 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tsc1 TSC complex subunit 1 multiple interactions EXP Liraglutide reverses the reaction [palmitate fatty acid decreases expression of tsc1 protein in hepatocytes] RGD PMID:31787541 RGD:25823196 NCBI chr 3:32,367,434...32,416,565
Ensembl chr 3:32,367,670...32,416,568 		JBrowse link
G Xdh xanthine dehydrogenase multiple interactions ISO Liraglutide inhibits the reaction [Pyruvaldehyde results in increased expression of XDH mRNA] CTD PMID:35985417 NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:27,282,057...27,344,350 		JBrowse link
micafungin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions EXP
ISO 		Micafungin inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein] CTD PMID:39089415 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Malt1 MALT1 paracaspase multiple interactions
affects binding 		EXP
ISO 		MALT1 protein inhibits the reaction [Micafungin inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 protein]]; MALT1 protein inhibits the reaction [Micafungin inhibits the reaction [Doxorubicin results in increased ubiquitination of NFE2L2 protein]]; Micafungin inhibits the reaction [Doxorubicin promotes the reaction [MALT1 protein binds to NFE2L2 protein]]; Micafungin inhibits the reaction [Doxorubicin results in increased expression of MALT1 protein]
Micafungin binds to MALT1 protein 		CTD PMID:39089415 NCBI chr18:61,212,290...61,266,272
Ensembl chr18:61,212,317...61,266,272 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP
ISO 		MALT1 protein inhibits the reaction [Micafungin inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 protein]]; MALT1 protein inhibits the reaction [Micafungin inhibits the reaction [Doxorubicin results in increased ubiquitination of NFE2L2 protein]]; Micafungin inhibits the reaction [Doxorubicin promotes the reaction [MALT1 protein binds to NFE2L2 protein]]; Micafungin inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 protein]; Micafungin inhibits the reaction [Doxorubicin results in increased ubiquitination of NFE2L2 protein] CTD PMID:39089415 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
N-palmitoyl-S-[2,3-bis(palmitoyloxy)propyl]-Cys-Ser-Lys-Lys-Lys-Lys term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Birc3 baculoviral IAP repeat-containing 3 increases expression ISO Pam3Cys increases expression of BIRC3 mRNA in colorectal cancer cells RGD PMID:29689497 RGD:152999011 NCBI chr 8:13,285,702...13,313,329
Ensembl chr 8:13,285,703...13,298,590 		JBrowse link
G Irak3 interleukin-1 receptor-associated kinase 3 increases expression ISO N-palmitoyl-S-[2,3-bis(palmitoyloxy)propyl]-Cys-Ser-Lys-Lys-Lys-Lys increases expression of Irak3 mRNA and protein in splenocyte
Pam3CSK4 increases expression of Irak3 mRNA and protein in peritoneal macrophages 		RGD PMID:28954388 PMID:21998452 RGD:34888230, RGD:36049794 NCBI chr 7:57,538,522...57,600,166
Ensembl chr 7:57,539,557...57,598,706 		JBrowse link
polymyxin B2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox12 arachidonate 12-lipoxygenase, 12S type increases expression
multiple interactions 		ISO Polymyxin B results in increased expression of ALOX12 protein
TP53 protein promotes the reaction [Polymyxin B results in increased expression of ALOX12 protein] 		CTD PMID:37088170 NCBI chr10:55,456,923...55,469,239
Ensembl chr10:55,456,928...55,469,199 		JBrowse link
G Atf3 activating transcription factor 3 multiple interactions ISO Polymyxin B promotes the reaction [Particulate Matter results in increased expression of ATF3 mRNA] CTD PMID:21652769 NCBI chr13:105,274,103...105,331,653
Ensembl chr13:105,282,440...105,295,750 		JBrowse link
G Atf4 activating transcription factor 4 increases expression
multiple interactions 		ISO Polymyxin B results in increased expression of ATF4 mRNA; Polymyxin B results in increased expression of ATF4 protein
7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine inhibits the reaction [Polymyxin B results in increased expression of ATF4 protein]; tetrahydrocurcumin inhibits the reaction [Polymyxin B results in increased expression of ATF4 mRNA]; tetrahydrocurcumin inhibits the reaction [Polymyxin B results in increased expression of ATF4 protein] 		CTD PMID:39023307 NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:113,684,681...113,686,739 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression 		ISO 7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine inhibits the reaction [Polymyxin B results in increased expression of BAX protein]; tetrahydrocurcumin inhibits the reaction [Polymyxin B results in increased expression of BAX mRNA]; tetrahydrocurcumin inhibits the reaction [Polymyxin B results in increased expression of BAX protein]
Polymyxin B results in increased expression of BAX mRNA; Polymyxin B results in increased expression of BAX protein 		CTD PMID:39023307 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions 		ISO Polymyxin B results in decreased expression of BCL2 mRNA; Polymyxin B results in decreased expression of BCL2 protein
7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine inhibits the reaction [Polymyxin B results in decreased expression of BCL2 protein]; tetrahydrocurcumin inhibits the reaction [Polymyxin B results in decreased expression of BCL2 mRNA]; tetrahydrocurcumin inhibits the reaction [Polymyxin B results in decreased expression of BCL2 protein] 		CTD PMID:39023307 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Casp12 caspase 12 increases expression
multiple interactions 		ISO Polymyxin B results in increased expression of CASP12 mRNA
7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine inhibits the reaction [Polymyxin B results in increased expression of and results in increased cleavage of CASP12 protein]; Polymyxin B results in increased expression of and results in increased cleavage of CASP12 protein; tetrahydrocurcumin inhibits the reaction [Polymyxin B results in increased expression of and results in increased cleavage of CASP12 protein]; tetrahydrocurcumin inhibits the reaction [Polymyxin B results in increased expression of CASP12 mRNA] 		CTD PMID:39023307 NCBI chr 8:10,927,188...10,954,442
Ensembl chr 8:10,926,994...10,954,442 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO 7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine inhibits the reaction [Polymyxin B results in increased expression of and results in increased cleavage of CASP3 protein]; Polymyxin B results in increased expression of and results in increased cleavage of CASP3 protein; tetrahydrocurcumin inhibits the reaction [Polymyxin B results in increased expression of and results in increased cleavage of CASP3 protein] CTD PMID:39023307 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Ccl11 C-C motif chemokine ligand 11 multiple interactions ISO Polymyxin B inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of CCL11 protein] CTD PMID:26882889 NCBI chr10:67,525,975...67,530,576
Ensembl chr10:67,525,862...67,530,575 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Polymyxin B inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of CCL2 protein]; Polymyxin B inhibits the reaction [Particulate Matter results in increased expression of CCL2 mRNA]; Polymyxin B inhibits the reaction [Particulate Matter results in increased secretion of CCL2 protein]; Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of CCL2 mRNA]]; Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of CCL2 protein]] CTD PMID:21652769 PMID:26882889 PMID:28555929 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions
decreases secretion 		ISO Acetylcysteine promotes the reaction [Polymyxin B inhibits the reaction [Particulate Matter results in increased secretion of CCL3 protein]]; Acetylcysteine promotes the reaction [Polymyxin B results in decreased secretion of CCL3 protein]; Polymyxin B inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of CCL3 protein]; Polymyxin B inhibits the reaction [Dust results in increased expression of CCL3 mRNA]; Polymyxin B inhibits the reaction [Particulate Matter results in increased expression of CCL3 mRNA]; Polymyxin B inhibits the reaction [Particulate Matter results in increased secretion of CCL3 protein]; Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of CCL3 mRNA]]; Polymyxin B promotes the reaction [Acetylcysteine results in decreased secretion of CCL3 protein] CTD PMID:26882889 PMID:28555929 NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Polymyxin B inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of CCL5 protein]
Polymyxin B inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CCL5 protein] 		CTD PMID:26882889 PMID:29348435 NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,738,651...68,824,884 		JBrowse link
G Ccl7 C-C motif chemokine ligand 7 multiple interactions ISO Polymyxin B inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of CCL7 protein] CTD PMID:26882889 NCBI chr10:67,514,095...67,515,945
Ensembl chr10:67,514,091...67,515,947 		JBrowse link
G Cd80 Cd80 molecule multiple interactions ISO Polymyxin B inhibits the reaction [Adenylate Cyclase Toxin results in increased expression of CD80 protein] CTD PMID:14977963 NCBI chr11:75,760,073...75,798,978
Ensembl chr11:75,760,147...75,797,540 		JBrowse link
G Cd86 CD86 molecule increases expression
multiple interactions 		ISO Polymyxin B results in increased expression of CD86 protein
Polymyxin B inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CD86 protein]
Polymyxin B inhibits the reaction [Adenylate Cyclase Toxin results in increased expression of CD86 protein] 		CTD PMID:14977963 PMID:15671028 PMID:30944281 NCBI chr11:77,647,565...77,706,178
Ensembl chr11:77,647,600...77,725,361 		JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions
decreases expression 		ISO Polymyxin B inhibits the reaction [Dextran Sulfate results in increased expression of CSF2 protein]
Polymyxin B results in decreased expression of CSF2 protein 		CTD PMID:31442584 NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,887,692...38,890,031 		JBrowse link
G Csf3 colony stimulating factor 3 multiple interactions ISO Polymyxin B inhibits the reaction [Lipopolysaccharides results in increased expression of CSF3 protein]; Polymyxin B promotes the reaction [Cadmium Chloride results in increased expression of CSF3 protein] CTD PMID:26790433 NCBI chr10:84,157,485...84,159,860
Ensembl chr10:84,157,211...84,159,860 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO Polymyxin B inhibits the reaction [Particulate Matter results in increased expression of CXCL2 mRNA] CTD PMID:21652769 NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,465,242...17,467,255 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO [Polymyxin B co-treated with Particulate Matter] results in increased expression of CXCL1 protein; MYD88 protein affects the reaction [Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of CXCL1 protein]]]; Polymyxin B inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of CXCL1 protein]; Polymyxin B inhibits the reaction [Dust results in increased expression of CXCL1 mRNA]; Polymyxin B inhibits the reaction [Particulate Matter results in increased secretion of CXCL1 protein]; Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of CXCL1 protein]] CTD PMID:26882889 PMID:28555929 NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,571,900...17,573,624 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Polymyxin B promotes the reaction [Particulate Matter results in increased expression of CYP1A1 mRNA] CTD PMID:20801209 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 multiple interactions EXP Polymyxin B inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased activity of and results in decreased expression of CYP2C11 protein] CTD PMID:18079364 NCBI chr 1:246,175,216...246,211,445
Ensembl chr 1:246,174,711...246,211,853 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions EXP Polymyxin B inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased activity of and results in decreased expression of CYP3A2 protein] CTD PMID:18079364 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions 		ISO Polymyxin B results in increased expression of DDIT3 mRNA; Polymyxin B results in increased expression of DDIT3 protein
7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine inhibits the reaction [Polymyxin B results in increased expression of DDIT3 protein]; tetrahydrocurcumin inhibits the reaction [Polymyxin B results in increased expression of DDIT3 mRNA]; tetrahydrocurcumin inhibits the reaction [Polymyxin B results in increased expression of DDIT3 protein] 		CTD PMID:39023307 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions
increases expression 		ISO 7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine inhibits the reaction [Polymyxin B results in increased expression of and results in increased phosphorylation of EIF2AK3 protein]; Polymyxin B results in increased expression of and results in increased phosphorylation of EIF2AK3 protein; tetrahydrocurcumin inhibits the reaction [Polymyxin B results in increased expression of and results in increased phosphorylation of EIF2AK3 protein]; tetrahydrocurcumin inhibits the reaction [Polymyxin B results in increased expression of EIF2AK3 mRNA] CTD PMID:39023307 NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:104,363,833...104,425,268 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases expression
multiple interactions 		ISO Polymyxin B results in increased expression of EIF2S1 mRNA
7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine inhibits the reaction [Polymyxin B results in increased expression of and results in increased phosphorylation of EIF2S1 protein]; Polymyxin B results in increased expression of and results in increased phosphorylation of EIF2S1 protein; tetrahydrocurcumin inhibits the reaction [Polymyxin B results in increased expression of and results in increased phosphorylation of EIF2S1 protein]; tetrahydrocurcumin inhibits the reaction [Polymyxin B results in increased expression of EIF2S1 mRNA] 		CTD PMID:39023307 NCBI chr 6:103,405,880...103,430,549
Ensembl chr 6:103,405,788...103,431,649 		JBrowse link
G Fth1 ferritin heavy chain 1 decreases expression ISO Polymyxin B results in decreased expression of FTH1 protein CTD PMID:37088170 NCBI chr 1:216,052,037...216,054,325
Ensembl chr 1:216,051,998...216,055,214 		JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions ISO Polymyxin B inhibits the reaction [Alpha-Amanitin results in decreased expression of GAPDH mRNA] CTD PMID:26385100 NCBI chr 4:159,648,592...159,653,436
Ensembl chr 4:159,648,592...159,653,377 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Polymyxin B results in increased expression of GCLM mRNA CTD PMID:37088170 NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003 		JBrowse link
G Gpnmb glycoprotein nmb increases secretion ISO Polymyxin B results in increased secretion of GPNMB protein CTD PMID:32905824 NCBI chr 4:79,341,128...79,362,366
Ensembl chr 4:79,341,021...79,380,240 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO [Polymyxin B co-treated with Methylprednisolone] inhibits the reaction [Alpha-Amanitin results in increased expression of GPT protein]; Polymyxin B inhibits the reaction [Alpha-Amanitin results in increased expression of GPT protein] CTD PMID:30891624 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160 		JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions
decreases expression 		ISO baicalein inhibits the reaction [Polymyxin B results in decreased expression of GPX4 protein]; SIRT1 protein promotes the reaction [baicalein inhibits the reaction [Polymyxin B results in decreased expression of GPX4 protein]]; SLC7A11 protein inhibits the reaction [Polymyxin B results in decreased expression of GPX4 protein]; TP53 protein promotes the reaction [Polymyxin B results in decreased expression of GPX4 protein]
Polymyxin B results in decreased expression of GPX4 mRNA; Polymyxin B results in decreased expression of GPX4 protein
GPX4 protein inhibits the reaction [Polymyxin B results in increased expression of PTGS2 protein] 		CTD PMID:37088170 PMID:37354967 NCBI chr 7:10,300,833...10,303,629
Ensembl chr 7:10,300,832...10,303,629 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 increases secretion ISO Polymyxin B results in increased secretion of HAVCR1 protein CTD PMID:32905824 NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,619,897...31,653,268 		JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions ISO Polymyxin B inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of CXCL8 protein]; Polymyxin B inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of TLR4 mRNA] CTD PMID:22014880 NCBI chr12:11,009,236...11,015,941
Ensembl chr16:39,039,050...39,041,327
Ensembl chr12:39,039,050...39,041,327 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression 		ISO Polymyxin B inhibits the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of HMOX1 mRNA]]
Polymyxin B results in increased expression of HMOX1 mRNA; Polymyxin B results in increased expression of HMOX1 protein
baicalein inhibits the reaction [Polymyxin B results in decreased expression of HMOX1 protein]; baicalein inhibits the reaction [Polymyxin B results in increased expression of HMOX1 protein]; SIRT1 protein promotes the reaction [baicalein inhibits the reaction [Polymyxin B results in decreased expression of HMOX1 protein]] 		CTD PMID:28555929 PMID:37088170 PMID:37354967 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression
multiple interactions 		ISO Polymyxin B results in increased expression of HSPA5 mRNA; Polymyxin B results in increased expression of HSPA5 protein
7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine inhibits the reaction [Polymyxin B results in increased expression of HSPA5 protein]; tetrahydrocurcumin inhibits the reaction [Polymyxin B results in increased expression of HSPA5 mRNA]; tetrahydrocurcumin inhibits the reaction [Polymyxin B results in increased expression of HSPA5 protein] 		CTD PMID:39023307 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Polymyxin B inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of ICAM1 protein]; Polymyxin B inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of ICAM1 protein] CTD PMID:24080332 PMID:30944281 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO Polymyxin B inhibits the reaction [Adenylate Cyclase Toxin results in increased expression of IL10 protein] CTD PMID:14977963 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580 		JBrowse link
G Il12a interleukin 12A multiple interactions ISO Polymyxin B inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of [IL12A protein binds to IL12B protein]] CTD PMID:26882889 NCBI chr 2:155,275,734...155,282,997
Ensembl chr 2:155,275,625...155,282,997 		JBrowse link
G Il12b interleukin 12B multiple interactions ISO Polymyxin B inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of [IL12A protein binds to IL12B protein]]; Polymyxin B inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein] CTD PMID:9278343 PMID:26882889 NCBI chr10:29,390,300...29,405,194
Ensembl chr10:29,389,905...29,405,194 		JBrowse link
G Il13 interleukin 13 multiple interactions ISO Polymyxin B inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of IL13 protein] CTD PMID:26882889 NCBI chr10:38,290,926...38,293,483
Ensembl chr10:38,290,926...38,293,483 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO Polymyxin B inhibits the reaction [Particulate Matter results in increased expression of IL1A mRNA] CTD PMID:21703343 NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Polymyxin B inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased secretion of IL1B protein]; Polymyxin B inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; Polymyxin B inhibits the reaction [Particulate Matter results in increased secretion of IL1B protein]; Polymyxin B inhibits the reaction [Vehicle Emissions results in increased secretion of IL1B protein]
Polymyxin B inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of IL1B protein]; Polymyxin B inhibits the reaction [Dust results in increased expression of IL1B mRNA]; Polymyxin B inhibits the reaction [Particulate Matter results in increased expression of IL1B mRNA] 		CTD PMID:14993811 PMID:18406506 PMID:26882889 PMID:27393915 PMID:35839670 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il5 interleukin 5 multiple interactions ISO Polymyxin B inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of IL5 protein] CTD PMID:26882889 NCBI chr10:38,375,132...38,378,003
Ensembl chr10:38,375,132...38,378,003 		JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression 		ISO
EXP 		Polymyxin B inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Polymyxin B inhibits the reaction [Particulate Matter results in increased secretion of IL6 protein]
Polymyxin B results in decreased expression of IL6 protein
Polymyxin B inhibits the reaction [Particulate Matter results in increased expression of IL6]
Dextran Sulfate inhibits the reaction [Polymyxin B results in decreased expression of IL6 protein]; MYD88 protein affects the reaction [Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of IL6 protein]]]; Polymyxin B inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of IL6 protein]; Polymyxin B inhibits the reaction [Dextran Sulfate results in increased expression of IL6 protein]; Polymyxin B inhibits the reaction [Dust results in increased expression of IL6 mRNA]; Polymyxin B inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Polymyxin B inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Polymyxin B inhibits the reaction [Particulate Matter results in increased secretion of IL6 protein]; Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of IL6 protein]] 		CTD PMID:8886760 PMID:12185005 PMID:20549640 PMID:21784459 PMID:26882889 More... NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Polymyxin B results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Polymyxin B results in increased phosphorylation of and results in increased activity of MAPK1 protein
Acetylcysteine promotes the reaction [Polymyxin B inhibits the reaction [Particulate Matter results in increased phosphorylation of MAPK1 protein]]; Polymyxin B inhibits the reaction [Particulate Matter results in increased phosphorylation of MAPK1 protein] 		CTD PMID:15671028 PMID:28555929 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Polymyxin B results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Polymyxin B results in increased phosphorylation of and results in increased activity of MAPK3 protein
Acetylcysteine promotes the reaction [Polymyxin B inhibits the reaction [Particulate Matter results in increased phosphorylation of MAPK3 protein]]; Polymyxin B inhibits the reaction [Particulate Matter results in increased phosphorylation of MAPK3 protein] 		CTD PMID:15671028 PMID:28555929 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO Polymyxin B inhibits the reaction [lipopolysaccharide, E. coli O26-B6 promotes the reaction [Nicotine results in increased expression of MMP1 protein]]; Polymyxin B inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of MMP1 protein]; Polymyxin B inhibits the reaction [Nicotine promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of MMP1 protein]] CTD PMID:18986645 NCBI chr 8:12,943,453...12,963,966
Ensembl chr 8:12,943,453...12,963,964 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [Polymyxin B co-treated with Methylprednisolone] inhibits the reaction [Alpha-Amanitin results in increased activity of MPO protein]; Polymyxin B inhibits the reaction [Alpha-Amanitin results in increased activity of MPO protein] CTD PMID:30891624 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056 		JBrowse link
G Mrgprx2 MAS related GPR family member X2 increases response to substance
multiple interactions 		ISO MRGPRX2 protein results in increased susceptibility to Polymyxin B
MRGPRX2 protein affects the reaction [Polymyxin B results in increased secretion of OGA protein] 		CTD PMID:31132327 NCBI chr 1:107,252,467...107,271,809 JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO [Particulate Matter co-treated with Acetylcysteine co-treated with Polymyxin B] results in increased secretion of MYD88 protein; [Particulate Matter co-treated with Polymyxin B] results in increased secretion of MYD88 protein; MYD88 protein affects the reaction [[Particulate Matter co-treated with Acetylcysteine co-treated with Polymyxin B] results in increased secretion of MYD88 protein]; MYD88 protein affects the reaction [Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of CXCL1 protein]]]; MYD88 protein affects the reaction [Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of IL6 protein]]]; MYD88 protein affects the reaction [Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of TNF protein]]] CTD PMID:28555929 NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:127,952,161...127,956,230 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP
ISO 		Polymyxin B inhibits the reaction [Indomethacin results in increased activity of NOS2 protein]
Polymyxin B inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] 		CTD PMID:12568917 PMID:23500011 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Oga O-GlcNAcase increases secretion
multiple interactions 		ISO Polymyxin B results in increased secretion of OGA protein
MRGPRX2 protein affects the reaction [Polymyxin B results in increased secretion of OGA protein] 		CTD PMID:31132327 NCBI chr 1:254,547,311...254,589,596
Ensembl chr 1:254,547,311...254,582,855 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression 		ISO baicalein inhibits the reaction [Polymyxin B results in increased expression of PTGS2 protein]; ferrostatin-1 inhibits the reaction [Polymyxin B results in increased expression of PTGS2 protein]; GPX4 protein inhibits the reaction [Polymyxin B results in increased expression of PTGS2 protein]; Polymyxin B affects the reaction [Particulate Matter results in increased expression of PTGS2 mRNA]; Polymyxin B inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; Polymyxin B inhibits the reaction [Particulate Matter results in increased expression of PTGS2 mRNA]; Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of PTGS2 mRNA]]
Polymyxin B promotes the reaction [Particulate Matter results in increased expression of PTGS2 mRNA] 		CTD PMID:21652769 PMID:23500011 PMID:27393915 PMID:28555929 PMID:37088170 More... NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Rig1 RNA sensor RIG-1 multiple interactions ISO Polymyxin B inhibits the reaction [Lipopolysaccharides results in increased expression of RIGI mRNA] CTD PMID:27183587 NCBI chr 5:60,117,398...60,165,995
Ensembl chr 5:60,117,398...60,165,995 		JBrowse link
G Sele selectin E multiple interactions ISO Polymyxin B promotes the reaction [Particulate Matter results in increased expression of SELE mRNA] CTD PMID:21652769 NCBI chr13:78,935,997...78,945,905
Ensembl chr13:78,936,036...78,945,903 		JBrowse link
G Sirt1 sirtuin 1 decreases expression
multiple interactions 		ISO Polymyxin B results in decreased expression of SIRT1 protein
baicalein inhibits the reaction [Polymyxin B results in decreased expression of SIRT1 protein]; SIRT1 protein promotes the reaction [baicalein inhibits the reaction [Polymyxin B results in decreased expression of GPX4 protein]]; SIRT1 protein promotes the reaction [baicalein inhibits the reaction [Polymyxin B results in decreased expression of HMOX1 protein]]; SIRT1 protein promotes the reaction [baicalein inhibits the reaction [Polymyxin B results in decreased expression of SLC7A11 protein]]; SIRT1 protein promotes the reaction [baicalein inhibits the reaction [Polymyxin B results in increased acetylation of TP53 protein]] 		CTD PMID:37354967 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 decreases expression
multiple interactions 		ISO Polymyxin B results in decreased expression of SLC7A11 protein
baicalein inhibits the reaction [Polymyxin B results in decreased expression of SLC7A11 protein]; SIRT1 protein promotes the reaction [baicalein inhibits the reaction [Polymyxin B results in decreased expression of SLC7A11 protein]]; SLC7A11 protein inhibits the reaction [Polymyxin B results in decreased expression of GPX4 protein]; TP53 protein promotes the reaction [Polymyxin B results in decreased expression of SLC7A11 protein] 		CTD PMID:37088170 PMID:37354967 NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695 		JBrowse link
G Tfrc transferrin receptor increases expression
multiple interactions 		ISO Polymyxin B results in increased expression of TFRC mRNA; Polymyxin B results in increased expression of TFRC protein
TP53 protein promotes the reaction [Polymyxin B results in increased expression of TFRC protein] 		CTD PMID:37088170 NCBI chr11:81,668,478...81,690,318
Ensembl chr11:81,668,478...81,690,318 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO Polymyxin B inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of TLR4 mRNA] CTD PMID:22014880 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
increases secretion 		ISO
EXP 		Dextran Sulfate inhibits the reaction [Polymyxin B results in decreased expression of TNF protein]; MYD88 protein affects the reaction [Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of TNF protein]]]; Polymyxin B inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]; Polymyxin B inhibits the reaction [Dust results in increased expression of TNF mRNA]; Polymyxin B inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Polymyxin B inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Polymyxin B inhibits the reaction [Particulate Matter results in increased expression of TNF mRNA]; Polymyxin B inhibits the reaction [Particulate Matter results in increased expression of TNF protein]; Polymyxin B inhibits the reaction [Particulate Matter results in increased secretion of TNF protein]; Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of TNF protein]]
Polymyxin B results in increased secretion of TNF protein
Polymyxin B inhibits the reaction [Particulate Matter results in increased expression of TNF]
Polymyxin B inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased secretion of TNF protein]; Polymyxin B inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]; Polymyxin B inhibits the reaction [Particulate Matter results in increased secretion of TNF protein]; Polymyxin B inhibits the reaction [Vehicle Emissions results in increased secretion of TNF protein] 		CTD PMID:8886760 PMID:12185005 PMID:18406506 PMID:26882889 PMID:28555929 More... NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO baicalein inhibits the reaction [Polymyxin B results in increased acetylation of TP53 protein]; Polymyxin B results in increased expression of and results in increased acetylation of TP53 protein; SIRT1 protein promotes the reaction [baicalein inhibits the reaction [Polymyxin B results in increased acetylation of TP53 protein]]; TP53 protein promotes the reaction [Polymyxin B results in decreased expression of GPX4 protein]; TP53 protein promotes the reaction [Polymyxin B results in decreased expression of SLC7A11 protein]; TP53 protein promotes the reaction [Polymyxin B results in increased expression of ALOX12 protein]; TP53 protein promotes the reaction [Polymyxin B results in increased expression of TFRC protein] CTD PMID:37088170 PMID:37354967 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
G Vegfa vascular endothelial growth factor A increases secretion ISO Polymyxin B results in increased secretion of VEGFA protein CTD PMID:32905824 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194 		JBrowse link
semaglutide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO
EXP 		[Tetradecanoylphorbol Acetate co-treated with Calcimycin] inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]]; HDAC5 protein inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]]; semaglutide inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein] CTD PMID:36075570 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP 		[Tetradecanoylphorbol Acetate co-treated with Calcimycin] inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP3 protein]]; HDAC5 protein inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP3 protein]]; semaglutide inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP3 protein] CTD PMID:36075570 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Hdac5 histone deacetylase 5 multiple interactions EXP
ISO 		semaglutide inhibits the reaction [Lipopolysaccharides results in increased expression of HDAC5 protein]
[Tetradecanoylphorbol Acetate co-treated with Calcimycin] inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased expression of HDAC5 protein]]; HDAC5 protein inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]]; HDAC5 protein inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP3 protein]]; HDAC5 protein inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]; HDAC5 protein inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]]; HDAC5 protein inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]]; HDAC5 protein inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; semaglutide inhibits the reaction [Lipopolysaccharides results in increased expression of HDAC5 protein] 		CTD PMID:36075570 NCBI chr10:87,653,139...87,688,078
Ensembl chr10:87,652,656...87,694,244 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP 		[Tetradecanoylphorbol Acetate co-treated with Calcimycin] inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]]; HDAC5 protein inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]]; semaglutide inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
semaglutide inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] 		CTD PMID:36075570 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO [Tetradecanoylphorbol Acetate co-treated with Calcimycin] inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]; HDAC5 protein inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]; semaglutide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein] CTD PMID:36075570 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [Tetradecanoylphorbol Acetate co-treated with Calcimycin] inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]]; HDAC5 protein inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]]; semaglutide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein] CTD PMID:36075570 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO 		semaglutide inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
[Tetradecanoylphorbol Acetate co-treated with Calcimycin] inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; HDAC5 protein inhibits the reaction [semaglutide inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; semaglutide inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] 		CTD PMID:36075570 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
surfactin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bak1 BCL2-antagonist/killer 1 increases expression ISO surfactin peptide results in increased expression of BAK1 protein CTD PMID:34850538 NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,102,335...5,110,974 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression 		ISO Acetylcysteine inhibits the reaction [surfactin peptide results in increased expression of BAX protein]; pyrazolanthrone inhibits the reaction [surfactin peptide results in increased expression of BAX protein] CTD PMID:19954742 PMID:34850538 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression 		ISO Acetylcysteine inhibits the reaction [surfactin peptide results in decreased expression of BCL2 protein]; pyrazolanthrone inhibits the reaction [surfactin peptide results in decreased expression of BCL2 protein] CTD PMID:19954742 PMID:34850538 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO surfactin peptide results in decreased expression of BCL2L1 protein CTD PMID:34850538 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907 		JBrowse link
G Capn1 calpain 1 increases expression ISO surfactin peptide results in increased expression of CAPN1 protein CTD PMID:34850538 NCBI chr 1:212,705,219...212,736,134
Ensembl chr 1:212,705,222...212,729,445 		JBrowse link
G Capn2 calpain 2 increases expression ISO surfactin peptide results in increased expression of CAPN2 protein CTD PMID:34850538 NCBI chr13:96,681,902...96,732,625
Ensembl chr13:96,681,848...96,732,625 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression 		ISO Acetylcysteine inhibits the reaction [surfactin peptide results in increased expression of CASP3 protein modified form]; CAT protein inhibits the reaction [surfactin peptide results in increased expression of CASP3 protein modified form]; surfactin peptide results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:19954742 PMID:34850538 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp6 caspase 6 multiple interactions
affects response to substance 		ISO Acetylcysteine inhibits the reaction [surfactin peptide results in increased cleavage of and results in increased activity of CASP6 protein]; pyrazolanthrone inhibits the reaction [surfactin peptide results in increased cleavage of and results in increased activity of CASP6 protein]; surfactin peptide results in increased cleavage of and results in increased activity of CASP6 protein
CASP6 protein affects the susceptibility to surfactin peptide 		CTD PMID:19954742 NCBI chr 2:221,140,287...221,152,727
Ensembl chr 2:221,140,256...221,152,726 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases cleavage 		ISO surfactin peptide results in increased cleavage of and results in increased activity of CASP9 protein
surfactin peptide results in increased cleavage of CASP9 protein 		CTD PMID:19954742 PMID:34850538 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [surfactin peptide results in increased abundance of Reactive Oxygen Species]; CAT protein inhibits the reaction [surfactin peptide results in increased expression of CASP3 protein modified form] CTD PMID:34850538 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions
affects localization 		ISO Acetylcysteine inhibits the reaction [surfactin peptide affects the localization of CYCS protein]; pyrazolanthrone inhibits the reaction [surfactin peptide affects the localization of CYCS protein] CTD PMID:19954742 NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 increases phosphorylation ISO surfactin peptide results in increased phosphorylation of ERN1 protein CTD PMID:34850538 NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,830,428...91,920,791 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
affects response to substance 		ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased susceptibility to [surfactin peptide results in increased expression of HMOX1 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased susceptibility to [surfactin peptide results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased susceptibility to [surfactin peptide results in increased expression of HMOX1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased susceptibility to [surfactin peptide results in increased expression of HMOX1 protein]; [tin protoporphyrin IX results in decreased activity of HMOX1 protein] results in decreased susceptibility to [surfactin peptide results in decreased susceptibility to [Lipopolysaccharides results in increased secretion of IL1B protein]]; [tin protoporphyrin IX results in decreased activity of HMOX1 protein] results in decreased susceptibility to [surfactin peptide results in decreased susceptibility to [Lipopolysaccharides results in increased secretion of IL6 protein]]; [tin protoporphyrin IX results in decreased activity of HMOX1 protein] results in decreased susceptibility to [surfactin peptide results in decreased susceptibility to [Lipopolysaccharides results in increased secretion of TNF protein]]; Cycloheximide results in decreased susceptibility to [surfactin peptide results in increased expression of HMOX1 protein]; Dactinomycin results in decreased susceptibility to [surfactin peptide results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the susceptibility to [surfactin peptide results in increased expression of HMOX1 protein]
surfactin peptide results in increased expression of HMOX1 mRNA; surfactin peptide results in increased expression of HMOX1 protein
HMOX1 protein affects the susceptibility to surfactin peptide 		CTD PMID:20833156 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 increases expression ISO surfactin peptide results in increased expression of HSP90B1 protein CTD PMID:34850538 NCBI chr 7:22,997,962...23,012,293
Ensembl chr 7:22,997,962...23,012,293 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO surfactin peptide results in increased expression of HSPA5 protein CTD PMID:34850538 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [tin protoporphyrin IX results in decreased activity of HMOX1 protein] results in decreased susceptibility to [surfactin peptide results in decreased susceptibility to [Lipopolysaccharides results in increased secretion of IL1B protein]]; surfactin peptide results in decreased susceptibility to [Lipopolysaccharides results in increased secretion of IL1B protein] CTD PMID:20833156 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO [tin protoporphyrin IX results in decreased activity of HMOX1 protein] results in decreased susceptibility to [surfactin peptide results in decreased susceptibility to [Lipopolysaccharides results in increased secretion of IL6 protein]]; surfactin peptide results in decreased susceptibility to [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:20833156 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 increases phosphorylation
multiple interactions 		ISO surfactin peptide results in increased phosphorylation of MAP3K5 protein
4-methylumbelliferone 8-carbaldehyde inhibits the reaction [surfactin peptide results in increased phosphorylation of MAP3K5 protein]; KIRA6 inhibits the reaction [surfactin peptide results in increased phosphorylation of MAP3K5 protein] 		CTD PMID:34850538 NCBI chr 1:16,505,387...16,723,899
Ensembl chr 1:16,505,596...16,723,898 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases expression 		ISO [[2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of MAPK1 protein] co-treated with [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of MAPK3 protein]] results in decreased susceptibility to surfactin peptide
surfactin peptide results in increased expression of MAPK1 protein modified form 		CTD PMID:19954742 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases expression 		ISO [[2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of MAPK1 protein] co-treated with [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of MAPK3 protein]] results in decreased susceptibility to surfactin peptide
surfactin peptide results in increased expression of MAPK3 protein modified form 		CTD PMID:19954742 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions 		ISO surfactin peptide results in increased phosphorylation of MAPK8 protein
4-methylumbelliferone 8-carbaldehyde inhibits the reaction [surfactin peptide results in increased phosphorylation of MAPK8 protein]; KIRA6 inhibits the reaction [surfactin peptide results in increased phosphorylation of MAPK8 protein] 		CTD PMID:34850538 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions
increases phosphorylation 		ISO 4-methylumbelliferone 8-carbaldehyde inhibits the reaction [surfactin peptide results in increased phosphorylation of MAPK9 protein]; KIRA6 inhibits the reaction [surfactin peptide results in increased phosphorylation of MAPK9 protein] CTD PMID:34850538 NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO NFE2L2 protein affects the susceptibility to [surfactin peptide results in increased expression of HMOX1 protein]; surfactin peptide affects the localization of and results in increased expression of NFE2L2 protein CTD PMID:20833156 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO surfactin peptide results in decreased susceptibility to [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein] CTD PMID:20833156 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO surfactin peptide results in increased cleavage of PARP1 protein CTD PMID:34850538 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO surfactin peptide results in decreased susceptibility to [Lipopolysaccharides affects the localization of RELA protein] CTD PMID:20833156 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [tin protoporphyrin IX results in decreased activity of HMOX1 protein] results in decreased susceptibility to [surfactin peptide results in decreased susceptibility to [Lipopolysaccharides results in increased secretion of TNF protein]]; surfactin peptide results in decreased susceptibility to [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:20833156 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
surfactin C term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bak1 BCL2-antagonist/killer 1 increases expression ISO surfactin peptide results in increased expression of BAK1 protein CTD PMID:34850538 NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,102,335...5,110,974 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression 		ISO Acetylcysteine inhibits the reaction [surfactin peptide results in increased expression of BAX protein]; pyrazolanthrone inhibits the reaction [surfactin peptide results in increased expression of BAX protein] CTD PMID:19954742 PMID:34850538 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression 		ISO Acetylcysteine inhibits the reaction [surfactin peptide results in decreased expression of BCL2 protein]; pyrazolanthrone inhibits the reaction [surfactin peptide results in decreased expression of BCL2 protein] CTD PMID:19954742 PMID:34850538 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO surfactin peptide results in decreased expression of BCL2L1 protein CTD PMID:34850538 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907 		JBrowse link
G Capn1 calpain 1 increases expression ISO surfactin peptide results in increased expression of CAPN1 protein CTD PMID:34850538 NCBI chr 1:212,705,219...212,736,134
Ensembl chr 1:212,705,222...212,729,445 		JBrowse link
G Capn2 calpain 2 increases expression ISO surfactin peptide results in increased expression of CAPN2 protein CTD PMID:34850538 NCBI chr13:96,681,902...96,732,625
Ensembl chr13:96,681,848...96,732,625 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression 		ISO Acetylcysteine inhibits the reaction [surfactin peptide results in increased expression of CASP3 protein modified form]; CAT protein inhibits the reaction [surfactin peptide results in increased expression of CASP3 protein modified form]; surfactin peptide results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:19954742 PMID:34850538 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp6 caspase 6 multiple interactions
affects response to substance 		ISO Acetylcysteine inhibits the reaction [surfactin peptide results in increased cleavage of and results in increased activity of CASP6 protein]; pyrazolanthrone inhibits the reaction [surfactin peptide results in increased cleavage of and results in increased activity of CASP6 protein]; surfactin peptide results in increased cleavage of and results in increased activity of CASP6 protein
CASP6 protein affects the susceptibility to surfactin peptide 		CTD PMID:19954742 NCBI chr 2:221,140,287...221,152,727
Ensembl chr 2:221,140,256...221,152,726 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases cleavage 		ISO surfactin peptide results in increased cleavage of and results in increased activity of CASP9 protein
surfactin peptide results in increased cleavage of CASP9 protein 		CTD PMID:19954742 PMID:34850538 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [surfactin peptide results in increased abundance of Reactive Oxygen Species]; CAT protein inhibits the reaction [surfactin peptide results in increased expression of CASP3 protein modified form] CTD PMID:34850538 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions
affects localization 		ISO Acetylcysteine inhibits the reaction [surfactin peptide affects the localization of CYCS protein]; pyrazolanthrone inhibits the reaction [surfactin peptide affects the localization of CYCS protein] CTD PMID:19954742 NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 increases phosphorylation ISO surfactin peptide results in increased phosphorylation of ERN1 protein CTD PMID:34850538 NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,830,428...91,920,791 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
affects response to substance
increases expression 		ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased susceptibility to [surfactin peptide results in increased expression of HMOX1 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased susceptibility to [surfactin peptide results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased susceptibility to [surfactin peptide results in increased expression of HMOX1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased susceptibility to [surfactin peptide results in increased expression of HMOX1 protein]; [tin protoporphyrin IX results in decreased activity of HMOX1 protein] results in decreased susceptibility to [surfactin peptide results in decreased susceptibility to [Lipopolysaccharides results in increased secretion of IL1B protein]]; [tin protoporphyrin IX results in decreased activity of HMOX1 protein] results in decreased susceptibility to [surfactin peptide results in decreased susceptibility to [Lipopolysaccharides results in increased secretion of IL6 protein]]; [tin protoporphyrin IX results in decreased activity of HMOX1 protein] results in decreased susceptibility to [surfactin peptide results in decreased susceptibility to [Lipopolysaccharides results in increased secretion of TNF protein]]; Cycloheximide results in decreased susceptibility to [surfactin peptide results in increased expression of HMOX1 protein]; Dactinomycin results in decreased susceptibility to [surfactin peptide results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the susceptibility to [surfactin peptide results in increased expression of HMOX1 protein]
HMOX1 protein affects the susceptibility to surfactin peptide
surfactin peptide results in increased expression of HMOX1 mRNA; surfactin peptide results in increased expression of HMOX1 protein 		CTD PMID:20833156 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 increases expression ISO surfactin peptide results in increased expression of HSP90B1 protein CTD PMID:34850538 NCBI chr 7:22,997,962...23,012,293
Ensembl chr 7:22,997,962...23,012,293 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO surfactin peptide results in increased expression of HSPA5 protein CTD PMID:34850538 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [tin protoporphyrin IX results in decreased activity of HMOX1 protein] results in decreased susceptibility to [surfactin peptide results in decreased susceptibility to [Lipopolysaccharides results in increased secretion of IL1B protein]]; surfactin peptide results in decreased susceptibility to [Lipopolysaccharides results in increased secretion of IL1B protein] CTD PMID:20833156 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO [tin protoporphyrin IX results in decreased activity of HMOX1 protein] results in decreased susceptibility to [surfactin peptide results in decreased susceptibility to [Lipopolysaccharides results in increased secretion of IL6 protein]]; surfactin peptide results in decreased susceptibility to [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:20833156 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 multiple interactions
increases phosphorylation 		ISO 4-methylumbelliferone 8-carbaldehyde inhibits the reaction [surfactin peptide results in increased phosphorylation of MAP3K5 protein]; KIRA6 inhibits the reaction [surfactin peptide results in increased phosphorylation of MAP3K5 protein] CTD PMID:34850538 NCBI chr 1:16,505,387...16,723,899
Ensembl chr 1:16,505,596...16,723,898 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases expression 		ISO [[2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of MAPK1 protein] co-treated with [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of MAPK3 protein]] results in decreased susceptibility to surfactin peptide
surfactin peptide results in increased expression of MAPK1 protein modified form 		CTD PMID:19954742 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases expression 		ISO [[2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of MAPK1 protein] co-treated with [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of MAPK3 protein]] results in decreased susceptibility to surfactin peptide
surfactin peptide results in increased expression of MAPK3 protein modified form 		CTD PMID:19954742 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation 		ISO 4-methylumbelliferone 8-carbaldehyde inhibits the reaction [surfactin peptide results in increased phosphorylation of MAPK8 protein]; KIRA6 inhibits the reaction [surfactin peptide results in increased phosphorylation of MAPK8 protein] CTD PMID:34850538 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation
multiple interactions 		ISO surfactin peptide results in increased phosphorylation of MAPK9 protein
4-methylumbelliferone 8-carbaldehyde inhibits the reaction [surfactin peptide results in increased phosphorylation of MAPK9 protein]; KIRA6 inhibits the reaction [surfactin peptide results in increased phosphorylation of MAPK9 protein] 		CTD PMID:34850538 NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO NFE2L2 protein affects the susceptibility to [surfactin peptide results in increased expression of HMOX1 protein]; surfactin peptide affects the localization of and results in increased expression of NFE2L2 protein CTD PMID:20833156 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO surfactin peptide results in decreased susceptibility to [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein] CTD PMID:20833156 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO surfactin peptide results in increased cleavage of PARP1 protein CTD PMID:34850538 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO surfactin peptide results in decreased susceptibility to [Lipopolysaccharides affects the localization of RELA protein] CTD PMID:20833156 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [tin protoporphyrin IX results in decreased activity of HMOX1 protein] results in decreased susceptibility to [surfactin peptide results in decreased susceptibility to [Lipopolysaccharides results in increased secretion of TNF protein]]; surfactin peptide results in decreased susceptibility to [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:20833156 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    chemical entity 20872
      group 20774
        organic group 19348
          amino-acid residue 11487
            peptide 11484
              lipopeptide 130
                Ac-Asp-N(6)-(4-bromobenzoyl)-KATIGFEVQEE 0
                Ac-Asp-N(6)-(5-chloropentanoyl)-KATIGFEVQEE 0
                Ac-Asp-N(6)-(6-bromohexanoyl)-KATIGFEVQEE 0
                Ac-Asp-N(6)-(chloroacetyl)-KATIGFEVQEE 0
                Ac-Asp-N(6)-(octanoyl)-KATIGFEVQEE 0
                Ac-Asp-N(6)-[(2,2,2-trifluoroethoxy)acetyl]-KATIGFEVQEE 0
                Ac-Asp-N(6)-[(2-iodophenyl)carbonyl]-KATIGFEVQEE 0
                Ac-Asp-N(6)-[(2E)-3-(3-nitrophenyl)prop-2-enoyl]-KATIGFEVQEE 0
                Ac-Asp-N(6)-[(2E)-3-(4-chlorophenyl)prop-2-enoyl]-KATIGFEVQEE 0
                Ac-Asp-N(6)-[(2E)-3-(m-tolyl)prop-2-enoyl]-KATIGFEVQEE 0
                Ac-Asp-N(6)-[2,5-bis(trifluoromethyl)benzoyl]-KATIGFEVQEE 0
                Ac-Asp-N(6)-[2-(trifluoromethyl)benzoyl]-KATIGFEVQEE 0
                Ac-Asp-N(6)-[3-(trifluoromethyl)benzoyl]-KATIGFEVQEE 0
                Ac-Asp-N(6)-[4-(trifluoromethyl)benzoyl]-KATIGFEVQEE 0
                Ac-Asp-N(6)-\{(2E)-3-[2-(trifluoromethyl)phenyl]prop-2-enoyl\}-KATIGFEVQEE 0
                Ac-Asp-N(6)-\{(2E)-3-[3-(trifluoromethyl)phenyl]prop-2-enoyl\}-KATIGFEVQEE 0
                Ac-Asp-N(6)-\{(2E)-3-[4-(trifluoromethyl)phenyl]prop-2-enoyl\}-KATIGFEVQEE 0
                Ac-Asp-N(6)-\{3-[2-(trifluoromethyl)phenyl]propanoyl\}-KATIGFEVQEE 0
                N-Ac-Asp-N(6)-lipoyl-KATIGFEVQEE 0
                N-tetradecanoylglycylpeptide 0
                Para-LP-01 0
                aculeacin A 0
                ciliatamide A 0
                ciliatamide B 0
                daptomycin 0
                diacyl lipopeptide + 0
                dragomabin 0
                dragonamide A 0
                echinocandin + 4
                emericellamide + 0
                glycopeptidolipid + 0
                lipopeptide antibiotic + 29
                liraglutide 37
                malacidin A 0
                malacidin B 0
                polymyxin + 93
                semaglutide 7
                syringomycin + 0
                triacyl lipopeptide + 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      carbon group element atom 20712
                        carbon atom 20706
                          organic molecular entity 20706
                            heteroorganic entity 20201
                              organochalcogen compound 19822
                                organooxygen compound 19713
                                  carboxamide 17697
                                    peptide 11484
                                      lipopeptide 130
                                        Ac-Asp-N(6)-(4-bromobenzoyl)-KATIGFEVQEE 0
                                        Ac-Asp-N(6)-(5-chloropentanoyl)-KATIGFEVQEE 0
                                        Ac-Asp-N(6)-(6-bromohexanoyl)-KATIGFEVQEE 0
                                        Ac-Asp-N(6)-(chloroacetyl)-KATIGFEVQEE 0
                                        Ac-Asp-N(6)-(octanoyl)-KATIGFEVQEE 0
                                        Ac-Asp-N(6)-[(2,2,2-trifluoroethoxy)acetyl]-KATIGFEVQEE 0
                                        Ac-Asp-N(6)-[(2-iodophenyl)carbonyl]-KATIGFEVQEE 0
                                        Ac-Asp-N(6)-[(2E)-3-(3-nitrophenyl)prop-2-enoyl]-KATIGFEVQEE 0
                                        Ac-Asp-N(6)-[(2E)-3-(4-chlorophenyl)prop-2-enoyl]-KATIGFEVQEE 0
                                        Ac-Asp-N(6)-[(2E)-3-(m-tolyl)prop-2-enoyl]-KATIGFEVQEE 0
                                        Ac-Asp-N(6)-[2,5-bis(trifluoromethyl)benzoyl]-KATIGFEVQEE 0
                                        Ac-Asp-N(6)-[2-(trifluoromethyl)benzoyl]-KATIGFEVQEE 0
                                        Ac-Asp-N(6)-[3-(trifluoromethyl)benzoyl]-KATIGFEVQEE 0
                                        Ac-Asp-N(6)-[4-(trifluoromethyl)benzoyl]-KATIGFEVQEE 0
                                        Ac-Asp-N(6)-\{(2E)-3-[2-(trifluoromethyl)phenyl]prop-2-enoyl\}-KATIGFEVQEE 0
                                        Ac-Asp-N(6)-\{(2E)-3-[3-(trifluoromethyl)phenyl]prop-2-enoyl\}-KATIGFEVQEE 0
                                        Ac-Asp-N(6)-\{(2E)-3-[4-(trifluoromethyl)phenyl]prop-2-enoyl\}-KATIGFEVQEE 0
                                        Ac-Asp-N(6)-\{3-[2-(trifluoromethyl)phenyl]propanoyl\}-KATIGFEVQEE 0
                                        N-Ac-Asp-N(6)-lipoyl-KATIGFEVQEE 0
                                        N-tetradecanoylglycylpeptide 0
                                        Para-LP-01 0
                                        aculeacin A 0
                                        ciliatamide A 0
                                        ciliatamide B 0
                                        daptomycin 0
                                        diacyl lipopeptide + 0
                                        dragomabin 0
                                        dragonamide A 0
                                        echinocandin + 4
                                        emericellamide + 0
                                        glycopeptidolipid + 0
                                        lipopeptide antibiotic + 29
                                        liraglutide 37
                                        malacidin A 0
                                        malacidin B 0
                                        polymyxin + 93
                                        semaglutide 7
                                        syringomycin + 0
                                        triacyl lipopeptide + 2
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