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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pyrrolopyrazole
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Accession:CHEBI:46866 term browser browse the term
Synonyms:related_synonym: pyrrolopyrazoles


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LY-2157299 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 multiple interactions ISO [ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of COL1A1 mRNA; [ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of CTNNB1 protein; [ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of FN1 protein; [ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of LAMC2 protein; [ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of TGFB1 mRNA; [ABCB4 protein affects the susceptibility to LY-2157299] which affects the phosphorylation of SMAD2 protein CTD PMID:29808285 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202 		JBrowse link
G Acan aggrecan decreases expression EXP LY-2157299 results in decreased expression of ACAN mRNA CTD PMID:29660438 NCBI chr 1:132,981,582...133,044,416
Ensembl chr 1:132,981,582...133,043,627 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO LY-2157299 inhibits the reaction [[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of ACTA2 mRNA] CTD PMID:35366062 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO [ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of COL1A1 mRNA CTD PMID:29808285 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Col1a2 collagen type I alpha 2 chain multiple interactions ISO LY-2157299 inhibits the reaction [[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of COL1A2 mRNA] CTD PMID:35366062 NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867 		JBrowse link
G Col2a1 collagen type II alpha 1 chain decreases expression EXP LY-2157299 results in decreased expression of COL2A1 mRNA CTD PMID:29660438 NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO [ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of CTNNB1 protein CTD PMID:29808285 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO [ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of FN1 protein CTD PMID:29808285 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Lamc2 laminin subunit gamma 2 multiple interactions ISO [ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of LAMC2 protein CTD PMID:29808285 NCBI chr13:65,284,664...65,344,164
Ensembl chr13:65,284,664...65,344,200 		JBrowse link
G Smad2 SMAD family member 2 multiple interactions ISO [ABCB4 protein affects the susceptibility to LY-2157299] which affects the phosphorylation of SMAD2 protein CTD PMID:29808285 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323 		JBrowse link
G Smad3 SMAD family member 3 multiple interactions EXP
ISO		 LY-2157299 inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:35122773 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO
EXP		 [ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of TGFB1 mRNA
LY-2157299 inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]
LY-2157299 inhibits the reaction [[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of ACTA2 mRNA]; LY-2157299 inhibits the reaction [[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of COL1A2 mRNA]; LY-2157299 inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]		 CTD PMID:29808285 PMID:35122773 PMID:35366062 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 decreases activity ISO LY-2157299 results in decreased activity of TGFBR1 protein CTD PMID:35122773 PMID:35366062 NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777 		JBrowse link
PF-3758309 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aatf apoptosis antagonizing transcription factor decreases expression ISO PF 3758309 results in decreased expression of AATF mRNA; PF 3758309 results in decreased expression of AATF protein CTD PMID:29048629 NCBI chr10:69,299,029...69,392,207
Ensembl chr10:69,299,037...69,392,201 		JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO PF 3758309 results in increased expression of BAD mRNA; PF 3758309 results in increased expression of BAD protein CTD PMID:29048629 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO PF 3758309 results in increased expression of BAK1 mRNA; PF 3758309 results in increased expression of BAK1 protein CTD PMID:29048629 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression ISO PF 3758309 results in decreased expression of BAX protein CTD PMID:29048629 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO PF 3758309 results in decreased expression of BCL2 protein CTD PMID:29048629 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2a1 BCL2-related protein A1 decreases expression ISO PF 3758309 results in decreased expression of BCL2A1 mRNA CTD PMID:29048629 NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO PF 3758309 results in decreased expression of BCL2L1 mRNA CTD PMID:29048629 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479 		JBrowse link
G Bcl2l2 Bcl2-like 2 increases expression ISO PF 3758309 results in increased expression of BCL2L2 mRNA CTD PMID:29048629 NCBI chr15:28,346,449...28,361,627
Ensembl chr15:28,356,807...28,361,624 		JBrowse link
G Bcl6 BCL6, transcription repressor increases expression ISO PF 3758309 results in increased expression of BCL6 mRNA CTD PMID:29048629 NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389 		JBrowse link
G Bclaf1 BCL2-associated transcription factor 1 decreases expression ISO PF 3758309 results in decreased expression of BCLAF1 mRNA CTD PMID:29048629 NCBI chr 1:15,088,436...15,117,666
Ensembl chr 1:15,070,894...15,148,832 		JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression ISO PF 3758309 results in increased expression of BDNF mRNA CTD PMID:29048629 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Bik BCL2-interacting killer increases expression ISO PF 3758309 results in increased expression of BIK mRNA CTD PMID:29048629 NCBI chr 7:114,672,277...114,691,296
Ensembl chr 7:114,672,277...114,691,296 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 decreases expression ISO PF 3758309 results in decreased expression of BIRC3 mRNA CTD PMID:29048629 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802 		JBrowse link
G Card6 caspase recruitment domain family, member 6 decreases expression ISO PF 3758309 results in decreased expression of CARD6 mRNA CTD PMID:29048629 NCBI chr 2:54,194,343...54,206,902
Ensembl chr 2:54,195,739...54,206,846 		JBrowse link
G Casp1 caspase 1 decreases expression ISO PF 3758309 results in decreased expression of CASP1 mRNA CTD PMID:29048629 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp6 caspase 6 decreases expression ISO PF 3758309 results in decreased expression of CASP6 mRNA CTD PMID:29048629 NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502 		JBrowse link
G Cd70 Cd70 molecule increases expression ISO PF 3758309 results in increased expression of CD70 mRNA CTD PMID:29048629 NCBI chr 9:2,006,563...2,009,715
Ensembl chr 9:2,006,563...2,009,715 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO PF 3758309 results in increased expression of CDKN1A mRNA; PF 3758309 results in increased expression of CDKN1A protein CTD PMID:29048629 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta decreases expression ISO PF 3758309 results in decreased expression of CEBPB mRNA CTD PMID:29048629 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473 		JBrowse link
G Cryab crystallin, alpha B increases expression ISO PF 3758309 results in increased expression of CRYAB mRNA CTD PMID:29048629 NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157 		JBrowse link
G Eda ectodysplasin-A increases expression ISO PF 3758309 results in increased expression of EDA mRNA CTD PMID:29048629 NCBI chr  X:65,078,454...65,480,172
Ensembl chr  X:65,078,673...65,480,172 		JBrowse link
G Eef1a2 eukaryotic translation elongation factor 1 alpha 2 increases expression ISO PF 3758309 results in increased expression of EEF1A2 mRNA CTD PMID:29048629 NCBI chr 3:168,265,893...168,275,071
Ensembl chr 3:168,195,357...168,275,071 		JBrowse link
G Ifnb1 interferon beta 1 increases expression ISO PF 3758309 results in increased expression of IFNB1 mRNA CTD PMID:29048629 NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523 		JBrowse link
G Ltb lymphotoxin beta increases expression ISO PF 3758309 results in increased expression of LTB mRNA CTD PMID:29048629 NCBI chr20:3,627,536...3,629,381
Ensembl chr20:3,627,537...3,629,381 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO PF 3758309 results in decreased phosphorylation of MAPK1 protein CTD PMID:29048629 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO PF 3758309 results in decreased phosphorylation of MAPK3 protein CTD PMID:29048629 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8ip2 mitogen-activated protein kinase 8 interacting protein 2 increases expression ISO PF 3758309 results in increased expression of MAPK8IP2 mRNA CTD PMID:29048629 NCBI chr 7:120,526,732...120,536,982
Ensembl chr 7:120,526,732...120,536,982 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 decreases expression ISO PF 3758309 results in decreased expression of NFKB1 mRNA CTD PMID:29048629 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nkx3-1 NK3 homeobox 1 increases expression ISO PF 3758309 results in increased expression of NKX3-1 mRNA CTD PMID:29048629 NCBI chr15:44,473,851...44,476,443
Ensembl chr15:44,473,851...44,476,441 		JBrowse link
G Nol3 nucleolar protein 3 increases expression ISO PF 3758309 results in increased expression of NOL3 mRNA CTD PMID:29048629 NCBI chr19:33,154,061...33,158,250
Ensembl chr19:33,154,062...33,158,250 		JBrowse link
G Pak4 p21 (RAC1) activated kinase 4 decreases expression
increases response to substance		 ISO PF 3758309 results in decreased expression of PAK4 protein
PAK4 protein results in increased susceptibility to PF 3758309		 CTD PMID:29048629 NCBI chr 1:83,849,904...83,889,188
Ensembl chr 1:83,849,904...83,859,413 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO PF 3758309 results in increased cleavage of PARP1 protein CTD PMID:29048629 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pim2 Pim-2 proto-oncogene, serine/threonine kinase decreases expression ISO PF 3758309 results in decreased expression of PIM2 mRNA CTD PMID:29048629 NCBI chr  X:14,617,582...14,622,851
Ensembl chr  X:14,617,582...14,622,851 		JBrowse link
G Prkcz protein kinase C, zeta increases expression ISO PF 3758309 results in increased expression of PRKCZ mRNA CTD PMID:29048629 NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367 		JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 decreases expression ISO PF 3758309 results in decreased expression of RIPK2 mRNA CTD PMID:29048629 NCBI chr 5:29,630,806...29,662,804
Ensembl chr 5:29,631,570...29,662,657 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 decreases expression ISO PF 3758309 results in decreased expression of SOCS3 mRNA CTD PMID:29048629 NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787 		JBrowse link
G Stambp Stam binding protein decreases expression ISO PF 3758309 results in decreased expression of STAMBP mRNA CTD PMID:29048629 NCBI chr 4:116,055,563...116,083,563
Ensembl chr 4:116,056,057...116,080,543 		JBrowse link
G Tbx3 T-box transcription factor 3 increases expression ISO PF 3758309 results in increased expression of TBX3 mRNA CTD PMID:29048629 NCBI chr12:36,879,924...36,894,849
Ensembl chr12:36,881,445...36,893,708 		JBrowse link
G Tnfsf14 TNF superfamily member 14 increases expression ISO PF 3758309 results in increased expression of TNFSF14 mRNA CTD PMID:29048629 NCBI chr 9:2,068,295...2,073,128
Ensembl chr 9:2,069,104...2,073,216 		JBrowse link
G Tnfsf18 TNF superfamily member 18 decreases expression ISO PF 3758309 results in decreased expression of TNFSF18 mRNA CTD PMID:29048629 NCBI chr13:73,833,478...73,907,249
Ensembl chr13:73,831,252...73,843,169 		JBrowse link
G Tnfsf8 TNF superfamily member 8 decreases expression ISO PF 3758309 results in decreased expression of TNFSF8 mRNA CTD PMID:29048629 NCBI chr 5:77,250,942...77,277,364
Ensembl chr 5:77,251,373...77,277,421 		JBrowse link
G Tp53i3 tumor protein p53 inducible protein 3 increases expression ISO PF 3758309 results in increased expression of TP53I3 mRNA CTD PMID:29048629 NCBI chr 6:27,818,327...27,825,753 JBrowse link
G Tradd TNFRSF1A-associated via death domain increases expression ISO PF 3758309 results in increased expression of TRADD mRNA CTD PMID:29048629 NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638 		JBrowse link
G Traf6 TNF receptor associated factor 6 increases expression ISO PF 3758309 results in increased expression of TRAF6 mRNA CTD PMID:29048629 NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    chemical entity 19872
      atom 19872
        nonmetal atom 19794
          nitrogen atom 18974
            nitrogen molecular entity 18974
              organonitrogen compound 18827
                organonitrogen heterocyclic compound 18148
                  pyrrolopyrazole 57
                    (3E)-N-(2,6-diethylphenyl)-3-\{[4-(4-methylpiperazin-1-yl)benzoyl]imino\}pyrrolo[3,4-c]pyrazole-5(3H)-carboxamide 0
                    4-(2-furanyl)-3-methyl-5-(4-methylphenyl)-2,4-dihydropyrrolo[3,4-c]pyrazol-6-one 0
                    4-(4-methylpiperazin-1-yl)-N-[5-(2-thienylacetyl)-1,5-dihydropyrrolo[3,4-c]pyrazol-3-yl]benzamide 0
                    LY-2157299 13
                    N-[(3E)-5-[(2R)-2-methoxy-2-phenylacetyl]pyrrolo[3,4-c]pyrazol-3(5H)-ylidene]-4-(4-methylpiperazin-1-yl)benzamide 0
                    PF-3758309 44
                    ZCAN262 0
                    omarigliptin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      p-block molecular entity 19811
                        carbon group molecular entity 19751
                          organic molecular entity 19748
                            organic molecule 19700
                              organic cyclic compound 19490
                                organic heterocyclic compound 18868
                                  organic heteropolycyclic compound 18294
                                    organic heterobicyclic compound 17237
                                      pyrrolopyrazole 57
                                        (3E)-N-(2,6-diethylphenyl)-3-\{[4-(4-methylpiperazin-1-yl)benzoyl]imino\}pyrrolo[3,4-c]pyrazole-5(3H)-carboxamide 0
                                        4-(2-furanyl)-3-methyl-5-(4-methylphenyl)-2,4-dihydropyrrolo[3,4-c]pyrazol-6-one 0
                                        4-(4-methylpiperazin-1-yl)-N-[5-(2-thienylacetyl)-1,5-dihydropyrrolo[3,4-c]pyrazol-3-yl]benzamide 0
                                        LY-2157299 13
                                        N-[(3E)-5-[(2R)-2-methoxy-2-phenylacetyl]pyrrolo[3,4-c]pyrazol-3(5H)-ylidene]-4-(4-methylpiperazin-1-yl)benzamide 0
                                        PF-3758309 44
                                        ZCAN262 0
                                        omarigliptin 0
paths to the root