diether - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	diether	go back to main search page
Accession:	CHEBI:46786	browse the term
Definition:	A polyether in which the number of ether linkages is 2.
Synonyms:	related_synonym:	diethers

show annotations for term's descendants Sort by:
Rat (996) Mouse (999) Human (1026) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (4) Green Monkey (0) Naked Mole-rat (0) All
Genes (996)

bexagliflozin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

solute carrier family 5 member 2

decreases activity

bexagliflozin results in decreased activity of SLC5A2 protein

PMID:21215314 PMID:36867399

NCBI chr 1:182,847,185...182,853,309
Ensembl chr 1:182,847,106...182,853,306

G

UDP glucuronosyltransferase family 1 member A9

increases metabolic processing

UGT1A9 protein results in increased metabolism of bexagliflozin

NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465

copanlisib

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

decreases phosphorylation

copanlisib results in decreased phosphorylation of AKT1 protein

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

Fas cell surface death receptor

affects response to substance

copanlisib affects the susceptibility to FAS protein

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

tumor necrosis factor

increases response to substance

copanlisib results in increased susceptibility to TNF protein

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

deguelin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 4

increases expression

deguelin results in increased expression of ABCC4 mRNA

NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283

G

ATP binding cassette subfamily C member 5

decreases expression

deguelin results in decreased expression of ABCC5 mRNA

NCBI chr11:80,473,809...80,567,257
Ensembl chr11:80,473,872...80,567,253

G

ATP binding cassette subfamily F member 1

decreases expression

deguelin results in decreased expression of ABCF1 mRNA

NCBI chr20:2,802,519...2,815,433
Ensembl chr20:2,802,488...2,815,433

G

ADAM metallopeptidase domain 12

decreases expression

deguelin results in decreased expression of ADAM12 mRNA

NCBI chr 1:188,686,984...189,014,206
Ensembl chr 1:188,686,989...189,020,667

G

ADAM metallopeptidase domain 8

decreases expression

deguelin results in decreased expression of ADAM8 mRNA

NCBI chr 1:194,776,559...194,789,330
Ensembl chr 1:194,770,060...194,788,801

G

adrenomedullin

multiple interactions

deguelin inhibits the reaction [Oxygen deficiency results in increased expression of ADM mRNA]

NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654

G

2-aminoethanethiol dioxygenase

increases expression

deguelin results in increased expression of ADO mRNA

NCBI chr20:21,044,815...21,045,983
Ensembl chr20:21,044,555...21,049,235

G

apoptosis enhancing nuclease

increases expression

deguelin results in increased expression of AEN mRNA

NCBI chr 1:132,815,094...132,824,522
Ensembl chr 1:132,815,142...132,824,523

G

apoptosis inducing factor, mitochondria associated 1

multiple interactions

deguelin results in increased expression of and affects the localization of AIFM1 protein

NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256

G

A-kinase anchoring protein 8 like

increases expression

deguelin results in increased expression of AKAP8L mRNA

NCBI chr 7:11,332,671...11,362,287
Ensembl chr 7:11,332,672...11,362,275

G

aldo-keto reductase family 1 member B1

decreases expression

deguelin results in decreased expression of AKR1B1 mRNA

NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157

G

aldo-keto reductase family 1, member C3

increases expression

deguelin results in increased expression of AKR1C3 mRNA

NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873

G

aldo-keto reductase family 7, member A2

decreases expression

deguelin results in decreased expression of AKR7A2 mRNA

NCBI chr 5:151,552,375...151,560,914
Ensembl chr 5:151,552,343...151,560,909

G

AKT serine/threonine kinase 1

decreases expression
affects phosphorylation
increases phosphorylation
multiple interactions
decreases phosphorylation

deguelin metabolite results in decreased expression of AKT1 protein; deguelin results in decreased expression of AKT1 mRNA; deguelin results in decreased expression of AKT1 protein
deguelin affects the phosphorylation of AKT1 protein
deguelin results in increased phosphorylation of AKT1 protein
deguelin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]
deguelin results in decreased phosphorylation of AKT1 protein

PMID:16288123 PMID:17015749 PMID:18593368 PMID:19139008 PMID:19336726 More...

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

aldehyde dehydrogenase 7 family, member A1

decreases expression

deguelin results in decreased expression of ALDH7A1 mRNA

NCBI chr18:50,003,242...50,042,193
Ensembl chr18:50,009,934...50,042,193

G

aldehyde dehydrogenase 8 family, member A1

decreases expression

deguelin results in decreased expression of ALDH8A1 mRNA

NCBI chr 1:16,183,940...16,203,385
Ensembl chr 1:16,183,940...16,203,385

G

amidohydrolase domain containing 2

decreases expression

deguelin results in decreased expression of AMDHD2 mRNA

NCBI chr10:13,187,579...13,196,148
Ensembl chr10:13,187,578...13,196,095

G

APC membrane recruitment protein 1

decreases expression

deguelin results in decreased expression of AMER1 mRNA

NCBI chr X:60,300,595...60,316,480
Ensembl chr X:60,295,751...60,316,440

G

angiopoietin-like 2

decreases expression

deguelin results in decreased expression of ANGPTL2 mRNA

NCBI chr 3:16,517,185...16,547,024
Ensembl chr 3:16,517,420...16,548,178

G

angiopoietin-like 4

multiple interactions

deguelin inhibits the reaction [Oxygen deficiency results in increased expression of ANGPTL4 mRNA]

NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519

G

anillin, actin binding protein

increases expression

deguelin results in increased expression of ANLN mRNA

NCBI chr 8:20,858,227...20,921,602
Ensembl chr 8:20,858,228...20,921,538

G

anoctamin 10

decreases expression

deguelin results in decreased expression of ANO10 mRNA

NCBI chr 8:121,841,664...121,960,739
Ensembl chr 8:121,841,665...121,962,670

G

annexin A7

increases expression

deguelin results in increased expression of ANXA7 mRNA

NCBI chr15:3,821,798...3,849,659
Ensembl chr15:3,821,845...3,849,385

G

adaptor related protein complex 2 subunit mu 1

decreases expression

deguelin results in decreased expression of AP2M1 mRNA

NCBI chr11:80,355,307...80,364,218
Ensembl chr11:80,328,041...80,364,140

G

adaptor related protein complex 3 subunit mu 1

decreases expression

deguelin results in decreased expression of AP3M1 mRNA

NCBI chr15:3,246,616...3,264,846
Ensembl chr15:3,246,926...3,264,844

G

amyloid beta precursor like protein 1

decreases expression

deguelin results in decreased expression of APLP1 mRNA

NCBI chr 1:85,696,880...85,707,215
Ensembl chr 1:85,696,882...85,707,155

G

androgen receptor

multiple interactions

deguelin results in decreased expression of and affects the localization of AR protein

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

Rho GTPase activating protein 8

increases expression

deguelin results in increased expression of ARHGAP8 mRNA

NCBI chr 7:115,842,223...115,902,094
Ensembl chr 7:115,850,654...115,902,093

G

Rho GTPase activating protein 9

increases expression

deguelin results in increased expression of ARHGAP9 mRNA

NCBI chr 7:63,148,573...63,157,025
Ensembl chr 7:63,148,900...63,157,524

G

Rho/Rac guanine nucleotide exchange factor 2

increases expression

deguelin results in increased expression of ARHGEF2 mRNA

NCBI chr 2:174,061,126...174,118,355
Ensembl chr 2:174,062,976...174,118,355

G

AT-rich interaction domain 4A

decreases expression

deguelin results in decreased expression of ARID4A mRNA

NCBI chr 6:89,522,459...89,593,868
Ensembl chr 6:89,522,442...89,593,510

G

ariadne RBR E3 ubiquitin protein ligase 2

increases expression

deguelin results in increased expression of ARIH2 mRNA

NCBI chr 8:109,296,738...109,355,909
Ensembl chr 8:109,296,738...109,355,852

G

ARF like GTPase 1

increases expression

deguelin results in increased expression of ARL1 mRNA

NCBI chr 7:23,120,004...23,131,173
Ensembl chr 7:23,119,589...23,131,898

G

aryl hydrocarbon receptor nuclear translocator

increases expression

deguelin results in increased expression of ARNT mRNA

NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580

G

arrestin domain containing 4

decreases expression

deguelin results in decreased expression of ARRDC4 mRNA

NCBI chr 1:122,369,355...122,383,351
Ensembl chr 1:122,369,360...122,383,290

G

arylsulfatase G

increases expression

deguelin results in increased expression of ARSG mRNA

NCBI chr10:94,412,261...94,551,224
Ensembl chr10:94,447,399...94,542,941

G

activating signal cointegrator 1 complex subunit 3

increases expression

deguelin results in increased expression of ASCC3 mRNA

NCBI chr20:53,510,137...53,795,446
Ensembl chr20:53,510,184...53,790,165

G

achaete-scute family bHLH transcription factor 1

increases expression

deguelin results in increased expression of ASCL1 mRNA

NCBI chr 7:21,903,136...21,906,003
Ensembl chr 7:21,903,126...21,905,993

G

anti-silencing function 1B histone chaperone

decreases expression

deguelin results in decreased expression of ASF1B mRNA

NCBI chr19:24,181,024...24,195,604
Ensembl chr19:24,181,028...24,195,549

G

asialoglycoprotein receptor 1

decreases expression

deguelin results in decreased expression of ASGR1 mRNA

NCBI chr10:54,775,727...54,779,642
Ensembl chr10:54,776,024...54,779,631

G

asparagine synthetase (glutamine-hydrolyzing)

increases expression

deguelin results in increased expression of ASNS mRNA

NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423

G

argininosuccinate synthase 1

increases expression

deguelin results in increased expression of ASS1 mRNA

NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903

G

activating transcription factor 4

increases expression

deguelin results in increased expression of ATF4 mRNA

NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446

G

activating transcription factor 5

increases expression

deguelin results in increased expression of ATF5 mRNA

NCBI chr 1:95,295,602...95,299,755
Ensembl chr 1:95,295,610...95,299,707

G

autophagy related 3

increases expression

deguelin results in increased expression of ATG3 mRNA

NCBI chr11:55,624,914...55,653,249
Ensembl chr11:55,624,917...55,653,224

G

5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase

increases expression

deguelin results in increased expression of ATIC mRNA

NCBI chr 9:73,164,846...73,184,897
Ensembl chr 9:73,164,846...73,184,889

G

ATM serine/threonine kinase

decreases expression

deguelin results in decreased expression of ATM mRNA

NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437

G

ATM interactor

decreases expression

deguelin results in decreased expression of ATMIN mRNA

NCBI chr19:44,996,506...45,013,606
Ensembl chr19:44,996,356...45,013,605

G

ATPase phospholipid transporting 11B (putative)

decreases expression

deguelin results in decreased expression of ATP11B mRNA

NCBI chr 2:118,585,348...118,691,076
Ensembl chr 2:118,585,342...118,690,232

G

ATPase phospholipid transporting 11C

decreases expression

deguelin results in decreased expression of ATP11C mRNA

NCBI chr X:138,564,459...138,752,116
Ensembl chr X:138,565,836...138,751,204

G

ATPase H+ transporting V0 subunit e1

decreases expression

deguelin results in decreased expression of ATP6V0E1 mRNA

NCBI chr10:16,479,656...16,502,732
Ensembl chr10:16,479,567...16,524,434

G

ATPase H+ transporting V1 subunit B2

decreases expression

deguelin results in decreased expression of ATP6V1B2 mRNA

NCBI chr16:20,617,515...20,641,651
Ensembl chr16:20,617,518...20,641,745

G

ATR serine/threonine kinase

decreases expression

deguelin results in decreased expression of ATR mRNA

NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136

G

all-trans retinoic acid-induced differentiation factor

increases expression

deguelin results in increased expression of ATRAID mRNA

NCBI chr 6:25,315,236...25,319,821

G

aurora kinase A

increases expression

deguelin results in increased expression of AURKA mRNA

NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390

G

beta-2 microglobulin

increases expression

deguelin results in increased expression of B2M mRNA

NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766

G

Beta-1,3-galactosyltransferase 6

decreases expression

deguelin results in decreased expression of B3GALT6 mRNA

NCBI chr 5:166,584,202...166,586,338
Ensembl chr 5:166,584,202...166,586,338

G

beta-1,3-glucuronyltransferase 1

decreases expression

deguelin results in decreased expression of B3GAT1 mRNA

NCBI chr 8:25,087,123...25,114,692
Ensembl chr 8:25,087,547...25,113,395

G

BAG cochaperone 3

increases expression

deguelin results in increased expression of BAG3 mRNA

NCBI chr 1:183,103,038...183,126,862
Ensembl chr 1:183,102,871...183,126,858

G

BCL2-antagonist/killer 1

increases expression

deguelin results in increased expression of BAK1 protein

NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264

G

BCL2 associated X, apoptosis regulator

increases expression

deguelin results in increased expression of BAX mRNA; deguelin results in increased expression of BAX protein

PMID:26592500 PMID:29512685

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

branched chain amino acid transaminase 1

increases expression

deguelin results in increased expression of BCAT1 mRNA

NCBI chr 4:177,964,834...178,046,573
Ensembl chr 4:177,964,834...178,046,597

G

BCL2, apoptosis regulator

decreases expression
multiple interactions

deguelin results in decreased expression of BCL2 mRNA; deguelin results in decreased expression of BCL2 protein
deguelin inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA]

PMID:19365708 PMID:22623043 PMID:26592500 PMID:29512685

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

multiple interactions
decreases expression

deguelin inhibits the reaction [TNF protein results in increased expression of BCL2L1 mRNA]
deguelin results in decreased expression of BCL2L1 mRNA; deguelin results in decreased expression of BCL2L1 protein

PMID:19365708 PMID:21472727 PMID:22623043 PMID:26592500

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

G

Bcl2-like 11

decreases expression

deguelin results in decreased expression of BCL2L11 mRNA

NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068

G

Bcl2-like 13

decreases expression

deguelin results in decreased expression of BCL2L13 mRNA

NCBI chr 4:154,056,116...154,112,890
Ensembl chr 4:154,056,127...154,108,985

G

Bcl2-like 2

decreases expression

deguelin results in decreased expression of BCL2L2 mRNA

NCBI chr15:28,346,449...28,361,627
Ensembl chr15:28,356,807...28,361,624

G

brain-derived neurotrophic factor

multiple interactions
increases expression

deguelin inhibits the reaction [BDNF protein results in increased expression of PPP1R1B protein]
deguelin results in increased expression of BDNF mRNA

PMID:17209049 PMID:33512557

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

BH3 interacting domain death agonist

decreases expression

deguelin results in decreased expression of BID mRNA

NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720

G

baculoviral IAP repeat-containing 5

multiple interactions
increases expression
decreases expression

deguelin inhibits the reaction [docetaxel results in increased expression of BIRC5 protein]; deguelin inhibits the reaction [Doxorubicin results in increased expression of BIRC5 protein]
deguelin results in increased expression of BIRC5 mRNA
deguelin results in decreased expression of BIRC5 protein

PMID:17035597 PMID:18593368 PMID:21472727 PMID:33512557

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

biogenesis of lysosomal organelles complex-1, subunit 2

increases expression

deguelin results in increased expression of BLOC1S2 mRNA

NCBI chr 1:243,024,611...243,031,749
Ensembl chr 1:243,024,614...243,031,653

G

Bcl2 modifying factor

decreases expression

deguelin results in decreased expression of BMF mRNA

NCBI chr 3:105,499,534...105,520,159
Ensembl chr 3:105,499,538...105,520,145

G

BCL2 interacting protein 3 like

increases expression

deguelin results in increased expression of BNIP3L mRNA

NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803

G

biphenyl hydrolase like

decreases expression

deguelin results in decreased expression of BPHL mRNA

NCBI chr17:30,800,939...30,837,277
Ensembl chr17:30,799,629...30,837,288

G

BRCA1, DNA repair associated

decreases expression

deguelin results in decreased expression of BRCA1 mRNA

NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304

G

bromodomain containing 2

increases expression

deguelin results in increased expression of BRD2 mRNA

NCBI chr20:4,727,078...4,735,389
Ensembl chr20:4,728,151...4,735,388

G

bromodomain containing 3

decreases expression

deguelin results in decreased expression of BRD3 mRNA

NCBI chr 3:10,773,163...10,829,675
Ensembl chr 3:10,775,272...10,829,577

G

BRMS1 like transcriptional repressor

decreases expression

deguelin results in decreased expression of BRMS1L mRNA

NCBI chr 6:73,266,673...73,300,630
Ensembl chr 6:73,266,691...73,300,631

G

basigin

increases expression

deguelin results in increased expression of BSG mRNA

NCBI chr 7:9,993,170...10,000,387
Ensembl chr 7:9,993,170...10,000,387

G

BTG anti-proliferation factor 3

increases expression

deguelin results in increased expression of BTG3 mRNA

NCBI chr11:17,030,156...17,046,069
Ensembl chr11:17,030,160...17,046,170

G

basic leucine zipper and W2 domains 1

decreases expression

deguelin results in decreased expression of BZW1 mRNA

NCBI chr 9:59,930,672...59,944,468
Ensembl chr 9:59,930,744...59,944,430

G

complement C1s

decreases expression

deguelin results in decreased expression of C1S mRNA

NCBI chr 4:157,430,249...157,442,438
Ensembl chr 4:157,430,117...157,442,303

G

C2 calcium-dependent domain containing 5

decreases expression

deguelin results in decreased expression of C2CD5 mRNA

NCBI chr 4:175,969,544...176,055,597
Ensembl chr 4:175,969,545...176,055,558

G

calcium binding and coiled coil domain 1

decreases expression

deguelin results in decreased expression of CALCOCO1 mRNA

NCBI chr 7:133,834,705...133,849,515
Ensembl chr 7:133,834,707...133,849,422

G

calmodulin 1

decreases expression

deguelin results in decreased expression of CALM1 mRNA

NCBI chr 6:119,487,691...119,495,759
Ensembl chr 6:119,487,621...119,498,227

G

calmodulin 3

decreases expression

deguelin results in decreased expression of CALM3 mRNA

NCBI chr 1:77,590,668...77,597,776
Ensembl chr 1:77,589,230...77,592,207

G

calreticulin

decreases expression

deguelin results in decreased expression of CALR mRNA

NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414

G

calumenin

decreases expression

deguelin results in decreased expression of CALU mRNA

NCBI chr 4:57,949,086...57,976,589
Ensembl chr 4:57,948,997...57,976,593

G

calcium/calmodulin-dependent protein kinase II beta

decreases expression

deguelin results in decreased expression of CAMK2B mRNA

NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994

G

calcium activated nucleotidase 1

decreases expression

deguelin results in decreased expression of CANT1 mRNA

NCBI chr10:103,637,079...103,650,240
Ensembl chr10:103,531,504...103,650,109

G

calnexin

increases expression

deguelin results in increased expression of CANX mRNA

NCBI chr10:34,623,865...34,656,866
Ensembl chr10:34,625,191...34,656,821

G

calpain 1

decreases expression

deguelin results in decreased expression of CAPN1 mRNA

NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177

G

calcyphosine

decreases expression

deguelin results in decreased expression of CAPS mRNA

NCBI chr 9:1,544,597...1,545,631
Ensembl chr 9:1,544,719...1,545,647

G

carbonic anhydrase 9

multiple interactions

deguelin inhibits the reaction [Oxygen deficiency results in increased expression of CA9 mRNA]

NCBI chr 5:57,763,234...57,769,838
Ensembl chr 5:57,763,206...57,769,838

G

capping protein regulator and myosin 1 linker 1

decreases expression

deguelin results in decreased expression of CARMIL1 mRNA

NCBI chr17:40,807,921...41,088,326
Ensembl chr17:40,808,389...41,088,326

G

cysteinyl-tRNA synthetase 1

increases expression

deguelin results in increased expression of CARS1 mRNA

NCBI chr 1:198,753,689...198,796,016
Ensembl chr 1:198,753,691...198,795,941

G

calcium/calmodulin dependent serine protein kinase

increases expression

deguelin results in increased expression of CASK mRNA

NCBI chr X:8,899,500...9,243,014
Ensembl chr X:8,899,833...9,238,694

G

caspase 3

increases cleavage
multiple interactions
increases activity

deguelin results in increased cleavage of CASP3 protein
[NPM1 protein mutant form results in increased susceptibility to deguelin] which results in increased cleavage of CASP3 protein
deguelin results in increased activity of CASP3 protein

PMID:18593368 PMID:19336726 PMID:22623043 PMID:22986522 PMID:25242579 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 6

multiple interactions

[NPM1 protein mutant form results in increased susceptibility to deguelin] which results in decreased expression of and results in increased activity of CASP6 protein

NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502

G

caspase 7

increases expression

deguelin metabolite results in increased expression of CASP7 protein modified form; deguelin results in increased expression of CASP7 protein modified form

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

caspase 8

multiple interactions

[NPM1 protein mutant form results in increased susceptibility to deguelin] which results in decreased expression of and results in increased activity of CASP8 protein

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

calpastatin

decreases expression

deguelin results in decreased expression of CAST mRNA

NCBI chr 2:3,973,112...4,082,658
Ensembl chr 2:3,973,112...4,082,659

G

Cbl proto-oncogene B

decreases expression

deguelin results in decreased expression of CBLB mRNA

NCBI chr11:48,589,878...48,756,940
Ensembl chr11:48,592,703...48,756,839

G

carbonyl reductase 1

decreases expression

deguelin results in decreased expression of CBR1 mRNA

NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393

G

chromobox 4

increases expression

deguelin results in increased expression of CBX4 mRNA

NCBI chr10:104,337,140...104,343,210
Ensembl chr10:104,336,876...104,356,706

G

C-C motif chemokine ligand 2

multiple interactions

deguelin promotes the reaction [Oxygen deficiency results in increased expression of CCL2 mRNA]

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 5

multiple interactions

deguelin inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

C-C motif chemokine ligand 9

decreases expression

deguelin results in decreased expression of CCL15 mRNA

NCBI chr10:68,366,486...68,371,408
Ensembl chr10:68,366,487...68,371,369

G

cyclin A2

increases expression

deguelin results in increased expression of CCNA2 mRNA

NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577

G

cyclin B1

increases expression

deguelin results in increased expression of CCNB1 mRNA

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

G

cyclin B2

increases expression

deguelin results in increased expression of CCNB2 mRNA

NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874

G

cyclin D1

multiple interactions
decreases expression

[deguelin results in increased degradation of CTNNB1 protein] which results in decreased expression of CCND1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [deguelin results in decreased expression of CCND1 protein]; deguelin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]

PMID:15960896 PMID:17015749 PMID:19861542 PMID:21472727

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin D3

decreases expression

deguelin results in decreased expression of CCND3 mRNA

NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371

G

cyclin E1

decreases expression

deguelin results in decreased expression of CCNE1 mRNA

NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101

G

cyclin E2

decreases expression

deguelin results in decreased expression of CCNE2 mRNA

NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632

G

cyclin G1

increases expression

deguelin results in increased expression of CCNG1 mRNA

NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641

G

cyclin H

increases expression

deguelin results in increased expression of CCNH mRNA

NCBI chr 2:15,835,064...15,855,648
Ensembl chr 2:15,834,833...15,855,819

G

chaperonin containing TCP1 subunit 6A

increases expression

deguelin results in increased expression of CCT6A mRNA

NCBI chr12:26,872,736...26,883,125
Ensembl chr12:26,872,574...26,883,337

G

CD14 molecule

multiple interactions

[NPM1 protein mutant form results in increased susceptibility to deguelin] which results in increased expression of CD14 protein

NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261

G

CD163 molecule

multiple interactions

[deguelin co-treated with Oxygen deficiency] results in increased expression of CD163 mRNA

NCBI chr 4:157,085,080...157,118,470
Ensembl chr 4:157,085,093...157,117,878

G

CD19 molecule

decreases expression

deguelin results in decreased expression of CD19 mRNA

NCBI chr 1:180,987,286...180,993,920
Ensembl chr 1:180,987,286...180,993,975

G

CD24 molecule

decreases expression

deguelin results in decreased expression of CD24 mRNA

NCBI chr20:47,074,353...47,079,662
Ensembl chr20:47,073,512...47,079,662

G

CD44 molecule

decreases expression

deguelin results in decreased expression of CD44 mRNA; deguelin results in decreased expression of CD44 protein

NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620

G

cell division cycle 45

decreases expression

deguelin results in decreased expression of CDC45 mRNA

NCBI chr11:82,185,427...82,210,630
Ensembl chr11:82,185,473...82,210,619

G

cell division cycle 6

decreases expression

deguelin results in decreased expression of CDC6 mRNA

NCBI chr10:83,864,189...83,878,011
Ensembl chr10:83,864,638...83,878,011

G

cadherin 1

multiple interactions
affects localization
increases expression

deguelin inhibits the reaction [TGFB1 protein results in increased expression of CDH1 protein]; deguelin promotes the reaction [CTNNB1 protein binds to CDH1 protein]
deguelin affects the localization of CDH1 protein
deguelin results in increased expression of CDH1 mRNA; deguelin results in increased expression of CDH1 protein

PMID:22986522 PMID:28509438

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

cadherin 10

decreases expression

deguelin results in decreased expression of CDH10 mRNA

NCBI chr 2:68,628,623...68,850,995
Ensembl chr 2:68,628,780...68,850,995

G

cadherin 2

decreases expression

deguelin results in decreased expression of CDH2 mRNA; deguelin results in decreased expression of CDH2 protein

PMID:22986522 PMID:33512557

NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167

G

cadherin 3

increases expression

deguelin results in increased expression of CDH3 mRNA

NCBI chr19:34,393,596...34,444,084
Ensembl chr19:34,393,727...34,444,084

G

cadherin 7

increases expression

deguelin results in increased expression of CDH7 mRNA

NCBI chr13:26,672,058...26,821,571
Ensembl chr13:26,672,484...26,819,846

G

cadherin 9

increases expression

deguelin results in increased expression of CDH9 mRNA

NCBI chr 2:66,280,422...66,367,121
Ensembl chr 2:66,228,117...66,367,121

G

cyclin-dependent kinase 1

increases expression

deguelin results in increased expression of CDK1 mRNA

NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408

G

cyclin-dependent kinase 4

decreases expression

deguelin metabolite results in decreased expression of CDK4 protein; deguelin results in decreased expression of CDK4 protein

PMID:19139008 PMID:19336726

NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403

G

cyclin-dependent kinase 5

decreases expression

deguelin results in decreased expression of CDK5 mRNA

NCBI chr 4:10,754,682...10,760,110
Ensembl chr 4:10,754,687...10,760,112

G

cyclin-dependent kinase 5 regulatory subunit 1

decreases expression

deguelin results in decreased expression of CDK5R1 mRNA

NCBI chr10:65,484,266...65,485,467
Ensembl chr10:65,483,941...65,488,456

G

cyclin-dependent kinase 6

increases expression

deguelin results in increased expression of CDK6 mRNA

NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634

G

cyclin-dependent kinase inhibitor 1A

decreases expression
increases expression

[deguelin results in decreased expression of NPM1 protein mutant form] which results in decreased expression of CDKN1A protein; deguelin metabolite results in decreased expression of CDKN1A protein; deguelin results in decreased expression of CDKN1A protein
deguelin results in increased expression of CDKN1A mRNA

PMID:19139008 PMID:25242579 PMID:29512685

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 1B

increases expression

deguelin results in increased expression of CDKN1B mRNA

NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982

G

cyclin-dependent kinase inhibitor 3

increases expression

deguelin results in increased expression of CDKN3 mRNA

NCBI chr15:20,022,522...20,033,948
Ensembl chr15:20,022,664...20,033,945

G

chromatin licensing and DNA replication factor 1

increases expression

deguelin results in increased expression of CDT1 mRNA

NCBI chr19:50,620,713...50,625,659
Ensembl chr19:50,620,713...50,625,659

G

CCAAT/enhancer binding protein alpha

decreases expression

[deguelin results in decreased expression of NPM1 protein mutant form] which results in decreased expression of CEBPA protein

NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412

G

CCAAT/enhancer binding protein beta

increases expression

deguelin results in increased expression of CEBPB mRNA

NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473

G

carboxyl ester lipase

decreases expression

deguelin results in decreased expression of CEL mRNA

NCBI chr 3:11,883,532...11,891,035
Ensembl chr 3:11,883,532...11,891,035

G

cell migration inducing hyaluronidase 2

decreases expression

deguelin results in decreased expression of CEMIP2 mRNA

NCBI chr 1:219,330,295...219,407,760
Ensembl chr 1:219,337,985...219,407,760

G

centromere protein F

increases expression

deguelin results in increased expression of CENPF mRNA

NCBI chr13:101,184,127...101,229,714
Ensembl chr13:101,184,127...101,229,669

G

centromere protein K

decreases expression

deguelin results in decreased expression of CENPK mRNA

NCBI chr 2:35,360,390...35,421,372
Ensembl chr 2:35,360,132...35,385,706

G

centromere protein U

increases expression

deguelin results in increased expression of CENPU mRNA

NCBI chr16:45,715,821...45,739,038
Ensembl chr16:45,714,294...45,738,823

G

centrosomal protein 55

increases expression

deguelin results in increased expression of CEP55 mRNA

NCBI chr 1:235,832,823...235,848,401
Ensembl chr 1:235,832,878...235,848,394

G

centrin 3

decreases expression

deguelin results in decreased expression of CETN3 mRNA

NCBI chr 2:12,089,025...12,101,828
Ensembl chr 2:12,089,226...12,101,828

G

CASP8 and FADD-like apoptosis regulator

multiple interactions
decreases expression

deguelin inhibits the reaction [TNF protein results in increased expression of CFLAR mRNA]
deguelin results in decreased expression of CFLAR mRNA

NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034

G

ChaC glutathione-specific gamma-glutamylcyclotransferase 1

increases expression

deguelin results in increased expression of CHAC1 mRNA

NCBI chr 3:106,342,302...106,345,526
Ensembl chr 3:106,342,302...106,345,526

G

checkpoint kinase 1

increases expression

deguelin results in increased expression of CHEK1 mRNA

NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009

G

choline kinase alpha

increases expression

deguelin results in increased expression of CHKA mRNA

NCBI chr 1:201,076,804...201,125,517
Ensembl chr 1:201,076,860...201,125,516

G

chimerin 1

increases expression

deguelin results in increased expression of CHN1 mRNA

NCBI chr 3:58,509,822...58,676,462
Ensembl chr 3:58,510,536...58,676,490

G

cholinergic receptor nicotinic alpha 4 subunit

decreases expression

deguelin results in decreased expression of CHRNA4 mRNA

NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957

G

cholinergic receptor nicotinic beta 2 subunit

decreases expression

deguelin results in decreased expression of CHRNB2 mRNA

NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619

G

component of inhibitor of nuclear factor kappa B kinase complex

increases expression

deguelin results in increased expression of CHUK mRNA

NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065

G

CDGSH iron sulfur domain 1

increases expression

deguelin results in increased expression of CISD1 mRNA

NCBI chr20:17,255,302...17,268,688
Ensembl chr20:17,255,151...17,284,924

G

CDC28 protein kinase regulatory subunit 1B

increases expression

deguelin results in increased expression of CKS1B mRNA

NCBI chr 2:174,833,025...174,837,614
Ensembl chr 2:174,833,050...174,837,636

G

CDC28 protein kinase regulatory subunit 2

increases expression

deguelin results in increased expression of CKS2 mRNA

NCBI chr17:13,570,611...13,575,770

G

claudin 2

increases expression

deguelin results in increased expression of CLDN2 mRNA

NCBI chr X:103,459,870...103,473,794
Ensembl chr X:103,459,780...103,474,838

G

claudin 5

increases expression
decreases expression

deguelin results in increased expression of CLDN5 mRNA
deguelin results in decreased expression of CLDN5 mRNA

PMID:19861542 PMID:33512557

NCBI chr11:82,212,822...82,214,248
Ensembl chr11:82,211,475...82,214,992

G

chloride intracellular channel 4

increases expression

deguelin results in increased expression of CLIC4 mRNA

NCBI chr 5:147,453,702...147,513,455
Ensembl chr 5:147,453,712...147,513,452

G

CDC-like kinase 1

increases expression

deguelin results in increased expression of CLK1 mRNA

NCBI chr 9:59,947,774...59,959,002
Ensembl chr 9:59,947,764...59,957,000

G

caseinolytic mitochondrial matrix peptidase chaperone subunit X

increases expression

deguelin results in increased expression of CLPX mRNA

NCBI chr 8:65,805,460...65,845,643
Ensembl chr 8:65,805,511...65,845,082

G

clathrin heavy chain

increases expression

deguelin results in increased expression of CLTC mRNA

NCBI chr10:71,517,661...71,574,591
Ensembl chr10:71,517,663...71,573,737

G

cms1 ribosomal small subunit homolog

increases expression

deguelin results in increased expression of CMSS1 mRNA

NCBI chr11:42,934,390...43,232,624
Ensembl chr11:42,934,440...43,232,624

G

contactin 1

decreases expression

deguelin results in decreased expression of CNTN1 mRNA

NCBI chr 7:123,263,146...123,560,896
Ensembl chr 7:123,372,792...123,558,541

G

cytochrome c oxidase assembly factor 6

increases expression

deguelin results in increased expression of COA6 mRNA

NCBI chr19:54,395,746...54,398,348
Ensembl chr19:54,395,742...54,399,407

G

collagen type IV alpha 2 chain

increases expression

deguelin results in increased expression of COL4A2 mRNA

NCBI chr16:78,047,591...78,183,360
Ensembl chr16:78,047,602...78,183,839

G

catechol-O-methyltransferase

increases expression

deguelin results in increased expression of COMT mRNA

NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642

G

COP9 signalosome subunit 5

decreases expression

deguelin results in decreased expression of COPS5 mRNA

NCBI chr 5:9,192,233...9,210,498
Ensembl chr 5:9,192,100...9,210,731

G

coronin 1A

decreases expression

deguelin results in decreased expression of CORO1A mRNA

NCBI chr 1:181,295,561...181,300,566
Ensembl chr 1:181,295,562...181,300,534

G

copine 3

decreases expression

deguelin results in decreased expression of CPNE3 mRNA

NCBI chr 5:33,014,658...33,063,934
Ensembl chr 5:33,016,307...33,063,934

G

cramped chromatin regulator homolog 1

decreases expression

deguelin results in decreased expression of CRAMP1 mRNA

NCBI chr10:13,983,781...14,032,409
Ensembl chr10:13,983,866...14,032,392

G

CREB3 regulatory factor

increases expression

deguelin results in increased expression of CREBRF mRNA

NCBI chr10:16,399,170...16,479,650
Ensembl chr10:16,404,596...16,461,999

G

CRK proto-oncogene, adaptor protein

decreases expression

deguelin results in decreased expression of CRK mRNA

NCBI chr10:60,530,469...60,556,703
Ensembl chr10:60,530,464...60,553,406

G

CRK like proto-oncogene, adaptor protein

increases expression

deguelin results in increased expression of CRKL mRNA

NCBI chr11:83,528,788...83,563,214
Ensembl chr11:83,526,530...83,563,238

G

colony stimulating factor 1 receptor

multiple interactions

deguelin inhibits the reaction [TNF protein results in increased export of CSF1R protein]

NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415

G

casein kinase 1, alpha 1

decreases expression

deguelin results in decreased expression of CSNK1A1 mRNA

NCBI chr18:55,017,049...55,050,184
Ensembl chr18:55,017,055...55,049,271

G

cysteine and serine rich nuclear protein 1

increases expression

deguelin results in increased expression of CSRNP1 mRNA

NCBI chr 8:119,704,712...119,717,767
Ensembl chr 8:119,704,713...119,718,183

G

cystathionine gamma-lyase

increases expression

deguelin results in increased expression of CTH mRNA

NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234

G

catenin alpha-like 1

increases expression

deguelin results in increased expression of CTNNAL1 mRNA

NCBI chr 5:71,514,340...71,569,431
Ensembl chr 5:71,514,340...71,569,431

G

catenin beta 1

multiple interactions
decreases expression
increases degradation

[deguelin results in increased degradation of CTNNB1 protein] which results in decreased expression of CCND1 protein; [deguelin results in increased degradation of CTNNB1 protein] which results in decreased expression of MYC protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [deguelin results in decreased expression of CTNNB1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [deguelin results in increased degradation of CTNNB1 protein]; deguelin promotes the reaction [CTNNB1 protein binds to CDH1 protein]
deguelin results in decreased expression of CTNNB1 mRNA; deguelin results in decreased expression of CTNNB1 protein

PMID:21472727 PMID:22986522 PMID:33512557

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

catenin delta 1

decreases expression

deguelin results in decreased expression of CTNND1 mRNA

NCBI chr 3:69,683,328...69,734,550
Ensembl chr 3:69,683,313...69,734,516

G

CTP synthase 1

decreases expression

deguelin results in decreased expression of CTPS1 mRNA

NCBI chr 5:134,125,022...134,154,155
Ensembl chr 5:134,125,025...134,154,180

G

cathepsin D

increases expression

deguelin results in increased expression of CTSD mRNA

NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488

G

cathepsin S

decreases expression

deguelin results in decreased expression of CTSS mRNA

NCBI chr 2:183,086,437...183,114,483
Ensembl chr 2:183,086,437...183,114,483

G

cortactin

decreases expression

deguelin results in decreased expression of CTTN mRNA

NCBI chr 1:199,599,710...199,635,254
Ensembl chr 1:199,599,710...199,635,164

G

C-X-C motif chemokine receptor 4

multiple interactions
decreases expression

deguelin inhibits the reaction [Oxygen deficiency results in increased expression of CXCR4 mRNA]
deguelin results in decreased expression of CXCR4 mRNA

PMID:22745725 PMID:33512557

NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883

G

cytochrome c, somatic

decreases expression

deguelin results in decreased expression of CYCS mRNA

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions

deguelin inhibits the reaction [1-nitropyrene results in increased stability of CYP1A1 mRNA]

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 26, subfamily b, polypeptide 1

decreases expression

deguelin results in decreased expression of CYP26B1 mRNA

NCBI chr 4:117,041,808...117,058,628
Ensembl chr 4:117,041,808...117,058,628

G

cytochrome P450, family 2, subfamily d, polypeptide 1

decreases expression

deguelin results in decreased expression of CYP2D7 mRNA

NCBI chr 7:113,908,950...113,913,420
Ensembl chr 7:113,908,947...113,922,084

G

cytochrome P450, family 3, subfamily a, polypeptide 9

affects expression

deguelin affects the expression of CYP3A5 mRNA

NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422

G

dishevelled associated activator of morphogenesis 1

decreases expression

deguelin results in decreased expression of DAAM1 mRNA

NCBI chr 6:90,389,544...90,550,114
Ensembl chr 6:90,389,688...90,550,114

G

death-domain associated protein

decreases expression

deguelin results in decreased expression of DAXX mRNA

NCBI chr20:4,970,090...4,976,145
Ensembl chr20:4,970,092...4,975,843

G

DBF4-CDC7 kinase regulatory subunit

increases expression

deguelin results in increased expression of DBF4 mRNA

NCBI chr 4:25,676,570...25,701,152
Ensembl chr 4:25,676,634...25,701,066

G

dysbindin domain containing 2

decreases expression

deguelin results in decreased expression of DBNDD2 mRNA

NCBI chr 3:153,216,300...153,220,651
Ensembl chr 3:153,191,090...153,220,651

G

dCMP deaminase

increases expression

deguelin results in increased expression of DCTD mRNA

NCBI chr16:44,066,952...44,098,654
Ensembl chr16:44,055,128...44,098,446

G

doublecortin

decreases expression

deguelin results in decreased expression of DCX mRNA

NCBI chr X:107,430,767...107,573,612
Ensembl chr X:107,430,767...107,507,476

G

dopa decarboxylase

decreases expression

deguelin results in decreased expression of DDC mRNA

PMID:33512557 PMID:34642769

NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208

G

DNA-damage inducible transcript 3

increases expression

deguelin results in increased expression of DDIT3 mRNA

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

DENN domain containing 3

decreases expression

deguelin results in decreased expression of DENND3 mRNA

NCBI chr 7:105,415,870...105,473,583
Ensembl chr 7:105,415,677...105,473,592

G

DEP domain containing 1B

increases expression

deguelin results in increased expression of DEPDC1B mRNA

NCBI chr 2:39,891,163...39,963,779
Ensembl chr 2:39,891,481...39,963,779

G

DNA fragmentation factor subunit beta

decreases expression

deguelin results in decreased expression of DFFB mRNA

NCBI chr 5:164,522,446...164,534,733
Ensembl chr 5:164,522,463...164,534,628

G

dehydrodolichyl diphosphate synthase subunit

decreases expression

deguelin results in decreased expression of DHDDS mRNA

NCBI chr 5:146,198,359...146,224,479
Ensembl chr 5:146,197,457...146,224,454

G

dehydrogenase/reductase 7

increases expression

deguelin results in increased expression of DHRS7 mRNA

NCBI chr 6:91,332,259...91,347,856
Ensembl chr 6:91,251,323...91,347,892

G

DEAH-box helicase 15

increases expression

deguelin results in increased expression of DHX15 mRNA

NCBI chr14:58,787,147...58,825,083
Ensembl chr14:58,787,127...58,825,088

G

dickkopf WNT signaling pathway inhibitor 2

decreases expression

deguelin results in decreased expression of DKK2 mRNA

NCBI chr 2:220,568,338...220,660,225
Ensembl chr 2:220,568,338...220,660,225

G

dickkopf WNT signaling pathway inhibitor 4

increases expression

deguelin results in increased expression of DKK4 mRNA

NCBI chr16:69,403,215...69,406,580
Ensembl chr16:69,402,989...69,406,580

G

dihydrolipoamide S-acetyltransferase

increases expression

deguelin results in increased expression of DLAT mRNA

NCBI chr 8:50,979,151...51,004,435
Ensembl chr 8:50,978,051...51,004,479
Ensembl chr 1:50,978,051...51,004,479

G

DLG associated protein 5

increases expression

deguelin results in increased expression of DLGAP5 mRNA

NCBI chr15:20,633,964...20,664,569
Ensembl chr15:20,633,966...20,664,518

G

delta like canonical Notch ligand 4

decreases expression

deguelin results in decreased expression of DLL4 mRNA

NCBI chr 3:106,317,114...106,327,004
Ensembl chr 3:106,316,986...106,326,931

G

DnaJ heat shock protein family (Hsp40) member B1

increases expression

deguelin results in increased expression of DNAJB1 mRNA

NCBI chr19:24,522,731...24,526,419
Ensembl chr19:24,522,717...24,526,458

G

DnaJ heat shock protein family (Hsp40) member B9

increases expression

deguelin results in increased expression of DNAJB9 mRNA

NCBI chr 6:61,270,385...61,276,795
Ensembl chr 6:61,269,913...61,275,063

G

DnaJ heat shock protein family (Hsp40) member C15

increases expression

deguelin results in increased expression of DNAJC15 mRNA

NCBI chr15:53,182,060...53,249,675
Ensembl chr15:53,184,855...53,249,675

G

dynamin 1

decreases expression

deguelin results in decreased expression of DNM1 mRNA

NCBI chr 3:15,604,782...15,648,654
Ensembl chr 3:15,604,784...15,648,538

G

dynamin 1-like

increases expression

deguelin results in increased expression of DNM1L mRNA

NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482

G

dipeptidyl peptidase like 10

increases expression

deguelin results in increased expression of DPP10 mRNA

NCBI chr13:34,584,420...36,269,292
Ensembl chr13:34,595,868...36,269,292

G

dopamine receptor D2

decreases expression

deguelin results in decreased expression of DRD2 mRNA

NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875

G

dual specificity phosphatase 14

increases expression

deguelin results in increased expression of DUSP14 mRNA

NCBI chr10:68,936,483...68,966,347
Ensembl chr10:68,935,330...68,965,329

G

dual specificity phosphatase 3

increases expression

deguelin results in increased expression of DUSP3 mRNA

NCBI chr10:86,920,014...86,933,739
Ensembl chr10:86,920,014...86,933,962

G

dual specificity phosphatase 4

increases expression

deguelin results in increased expression of DUSP4 mRNA

NCBI chr16:57,376,659...57,398,161
Ensembl chr16:57,377,229...57,398,138

G

dual specificity tyrosine phosphorylation regulated kinase 3

decreases expression

deguelin results in decreased expression of DYRK3 mRNA

NCBI chr13:42,594,120...42,604,898
Ensembl chr13:42,594,121...42,604,778

G

E2F transcription factor 1

decreases expression

deguelin results in decreased expression of E2F1 mRNA

NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361

G

EBF transcription factor 1

decreases expression

deguelin results in decreased expression of EBF1 mRNA

NCBI chr10:29,095,858...29,489,142
Ensembl chr10:29,099,933...29,487,665

G

EBNA1 binding protein 2

decreases expression

deguelin results in decreased expression of EBNA1BP2 mRNA

NCBI chr 5:132,148,164...132,152,730
Ensembl chr 5:132,148,143...132,153,267

G

early endosome antigen 1

increases expression

deguelin results in increased expression of EEA1 mRNA

NCBI chr 7:30,554,686...30,722,186
Ensembl chr 7:30,554,552...30,718,487

G

eukaryotic translation elongation factor 1 beta 2

increases expression

deguelin results in increased expression of EEF1B2 mRNA

NCBI chr 9:64,580,163...64,582,737
Ensembl chr 9:64,579,893...64,582,737

G

epidermal growth factor receptor

decreases expression

deguelin metabolite results in decreased expression of EGFR protein; deguelin results in decreased expression of EGFR protein

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

egl-9 family hypoxia-inducible factor 3

multiple interactions

deguelin inhibits the reaction [Oxygen deficiency results in increased expression of EGLN3 mRNA]

NCBI chr 6:71,650,297...71,675,766
Ensembl chr 6:71,650,297...71,675,766

G

eukaryotic translation initiation factor 1

increases expression

deguelin results in increased expression of EIF1 mRNA

NCBI chr10:85,246,751...85,248,842
Ensembl chr10:85,246,764...85,427,327
Ensembl chr 5:85,246,764...85,427,327

G

eukaryotic translation initiation factor 2 alpha kinase 3

increases phosphorylation

deguelin results in increased phosphorylation of EIF2AK3 protein

NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911

G

eukaryotic translation initiation factor 2 subunit beta

increases expression

deguelin results in increased expression of EIF2S2 mRNA

NCBI chr 3:143,374,652...143,395,460
Ensembl chr 3:143,373,686...143,395,432

G

eukaryotic translation initiation factor 4B

increases expression

deguelin results in increased expression of EIF4B mRNA

NCBI chr 7:133,206,637...133,228,436

G

eukaryotic translation initiation factor 4E binding protein 1

decreases expression
increases expression
decreases phosphorylation

deguelin metabolite results in decreased expression of EIF4EBP1 protein modified form; deguelin results in decreased expression of EIF4EBP1 protein modified form
deguelin results in increased expression of EIF4EBP1 mRNA
deguelin results in decreased phosphorylation of EIF4EBP1 protein

PMID:19139008 PMID:27255535 PMID:33512557

NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984

G

ELAV like RNA binding protein 1

decreases expression

deguelin results in decreased expression of ELAVL1 mRNA

NCBI chr12:2,640,936...2,684,787
Ensembl chr12:2,645,061...2,684,784

G

ELMO domain containing 1

decreases expression

deguelin results in decreased expression of ELMOD1 mRNA

NCBI chr 8:54,298,363...54,355,348
Ensembl chr 8:54,298,363...54,355,140

G

elongator acetyltransferase complex subunit 1

decreases expression

deguelin results in decreased expression of ELP1 mRNA

NCBI chr 5:71,453,338...71,505,833
Ensembl chr 5:71,456,310...71,505,762

G

endonuclease G

decreases expression

deguelin results in decreased expression of ENDOG mRNA

NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932

G

enolase 2

decreases secretion
decreases expression

deguelin results in decreased secretion of ENO2 protein
deguelin results in decreased expression of ENO2 mRNA

PMID:26884827 PMID:33512557

NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980

G

ectonucleoside triphosphate diphosphohydrolase 1

multiple interactions

deguelin inhibits the reaction [Oxygen deficiency results in increased expression of ENTPD1 protein]

NCBI chr 1:239,425,515...239,552,323
Ensembl chr 1:239,425,430...239,552,317

G

E1A binding protein p300

decreases expression

deguelin results in decreased expression of EP300 mRNA

NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088

G

endothelial PAS domain protein 1

decreases expression

deguelin results in decreased expression of EPAS1 protein

NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228

G

Eph receptor B2

decreases expression

deguelin results in decreased expression of EPHB2 mRNA

NCBI chr 5:148,889,574...149,077,027
Ensembl chr 5:148,897,246...149,077,059

G

epidermal growth factor receptor pathway substrate 15

increases expression

deguelin results in increased expression of EPS15 mRNA

NCBI chr 5:124,045,865...124,146,221
Ensembl chr 5:124,045,926...124,146,221

G

endoplasmic reticulum to nucleus signaling 1

decreases expression

deguelin results in decreased expression of ERN1 protein

NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029

G

endoplasmic reticulum oxidoreductase 1 alpha

increases expression

deguelin results in increased expression of ERO1A mRNA

NCBI chr15:18,495,037...18,530,440
Ensembl chr15:18,492,945...18,530,478

G

eukaryotic translation termination factor 1

increases expression

deguelin results in increased expression of ETF1 mRNA

NCBI chr18:26,502,413...26,530,753
Ensembl chr18:26,504,080...26,530,810

G

ethanolamine kinase 1

decreases expression

deguelin results in decreased expression of ETNK1 mRNA

NCBI chr 4:176,126,056...176,170,325
Ensembl chr 4:176,126,180...176,193,770

G

ETS proto-oncogene 1, transcription factor

increases expression

deguelin results in increased expression of ETS1 mRNA

NCBI chr 8:31,045,909...31,168,010
Ensembl chr 8:31,045,945...31,168,010

G

ETS variant transcription factor 1

decreases expression

deguelin results in decreased expression of ETV1 mRNA

NCBI chr 6:55,590,149...55,681,784
Ensembl chr 6:55,590,234...55,681,775

G

Enah/Vasp-like

decreases expression

deguelin results in decreased expression of EVL mRNA

NCBI chr 6:127,473,119...127,594,342
Ensembl chr 6:127,474,543...127,594,344

G

exosome component 4

decreases expression

deguelin results in decreased expression of EXOSC4 mRNA

NCBI chr 7:108,047,831...108,050,573
Ensembl chr 7:108,047,831...108,050,573

G

exosome component 8

increases expression

deguelin results in increased expression of EXOSC8 mRNA

NCBI chr 2:138,930,405...138,937,009
Ensembl chr 2:138,930,405...138,936,928

G

family with sequence similarity 174, member A

decreases expression

deguelin results in decreased expression of FAM174A mRNA

NCBI chr 9:95,742,815...95,761,083
Ensembl chr 9:95,742,927...95,761,081

G

family with sequence similarity 72, member A

increases expression

deguelin results in increased expression of FAM72A mRNA

NCBI chr13:42,967,701...42,979,083
Ensembl chr13:42,967,578...42,984,208

G

Fas cell surface death receptor

increases expression

deguelin results in increased expression of FAS mRNA

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

fatty acid synthase

decreases expression

deguelin results in decreased expression of FASN mRNA

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

G

FAST kinase domains 5

decreases expression

deguelin results in decreased expression of FASTKD5 mRNA

NCBI chr 3:117,830,219...117,847,707
Ensembl chr 3:117,830,083...117,847,820

G

fibroblast growth factor 2

increases expression

deguelin results in increased expression of FGF2 mRNA

NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221

G

fin bud initiation factor homolog

increases expression

deguelin results in increased expression of FIBIN mRNA

NCBI chr 3:96,942,405...96,944,676
Ensembl chr 3:96,942,406...96,944,676

G

FIG4 phosphoinositide 5-phosphatase

decreases expression

deguelin results in decreased expression of FIG4 mRNA

NCBI chr20:44,600,603...44,724,047
Ensembl chr20:44,600,603...44,723,844

G

FIGNL1 interacting regulator of recombination and mitosis

decreases expression

deguelin results in decreased expression of FIRRM mRNA

NCBI chr13:76,301,914...76,345,842
Ensembl chr13:76,301,918...76,345,804

G

FKBP prolyl isomerase 14

decreases expression

deguelin results in decreased expression of FKBP14 mRNA

NCBI chr 4:83,705,531...83,721,515
Ensembl chr 4:83,705,652...83,721,528

G

FKBP prolyl isomerase 4

increases expression

deguelin results in increased expression of FKBP4 mRNA

NCBI chr 4:161,703,379...161,711,833
Ensembl chr 4:161,703,379...161,711,833

G

filamin A

increases expression

deguelin results in increased expression of FLNA mRNA

NCBI chr X:152,007,758...152,034,266
Ensembl chr X:152,007,758...152,031,052

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

deguelin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of FOS mRNA]

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

FOS like 1, AP-1 transcription factor subunit

increases expression

deguelin results in increased expression of FOSL1 mRNA

NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930

G

forkhead box J3

increases expression

deguelin results in increased expression of FOXJ3 mRNA

NCBI chr 5:133,140,344...133,228,489
Ensembl chr 5:133,140,884...133,228,489

G

forkhead box O4

decreases expression

deguelin results in decreased expression of FOXO4 mRNA

NCBI chr X:66,385,241...66,392,115
Ensembl chr X:66,385,558...66,392,115

G

frizzled-related protein

increases expression

deguelin results in increased expression of FRZB mRNA

NCBI chr 3:65,332,274...65,365,208
Ensembl chr 3:65,332,277...65,365,208

G

follistatin-like 1

decreases expression

deguelin results in decreased expression of FSTL1 mRNA

NCBI chr11:62,895,391...62,948,581
Ensembl chr11:62,779,783...62,948,677

G

ferritin heavy chain 1

increases expression

deguelin results in increased expression of FTH1 mRNA

NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424

G

ferritin light chain 1

increases expression

deguelin results in increased expression of FTL mRNA

NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725
Ensembl chr10:95,936,387...95,939,725
Ensembl chr 2:95,936,387...95,939,725

G

FYN proto-oncogene, Src family tyrosine kinase

decreases expression

deguelin results in decreased expression of FYN mRNA

NCBI chr20:42,767,733...42,960,903
Ensembl chr20:42,766,369...42,959,911

G

frizzled class receptor 10

increases expression

deguelin results in increased expression of FZD10 mRNA

NCBI chr12:28,098,371...28,101,566
Ensembl chr12:28,098,371...28,101,566

G

frizzled class receptor 4

increases expression

deguelin results in increased expression of FZD4 mRNA

NCBI chr 1:143,279,934...143,288,799
Ensembl chr 1:143,280,065...143,285,724

G

frizzled class receptor 8

increases expression

deguelin results in increased expression of FZD8 mRNA

NCBI chr17:57,312,924...57,320,551
Ensembl chr17:57,314,450...57,320,650

G

G3BP stress granule assembly factor 2

decreases expression

deguelin results in decreased expression of G3BP2 mRNA

NCBI chr14:15,932,403...16,020,555
Ensembl chr14:15,987,417...16,020,548

G

glucose-6-phosphate dehydrogenase

decreases expression

deguelin results in decreased expression of G6PD mRNA

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

alpha glucosidase

decreases expression

deguelin results in decreased expression of GAA mRNA

NCBI chr10:104,529,673...104,546,836
Ensembl chr10:104,529,747...104,546,836

G

GA binding protein transcription factor subunit beta 1

increases expression

deguelin results in increased expression of GABPB1 mRNA

NCBI chr 3:113,879,972...113,924,742
Ensembl chr 3:113,879,973...113,923,696

G

growth arrest and DNA-damage-inducible, alpha

increases expression

deguelin results in increased expression of GADD45A mRNA

NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115

G

UDP-galactose-4-epimerase

decreases expression

deguelin results in decreased expression of GALE mRNA

NCBI chr 5:148,193,886...148,198,392
Ensembl chr 5:148,194,791...148,198,388

G

polypeptide N-acetylgalactosaminyltransferase 3

decreases expression

deguelin results in decreased expression of GALNT3 mRNA

NCBI chr 3:50,742,500...50,779,266
Ensembl chr 3:50,742,512...50,766,268

G

growth associated protein 43

decreases expression

deguelin results in decreased expression of GAP43 mRNA

NCBI chr11:58,376,371...58,470,047
Ensembl chr11:58,376,371...58,470,045

G

GATA binding protein 2

increases expression

deguelin results in increased expression of GATA2 mRNA

NCBI chr 4:120,654,205...120,667,763
Ensembl chr 4:120,658,986...120,667,761

G

glutamate-cysteine ligase, catalytic subunit

increases expression

deguelin results in increased expression of GCLC mRNA

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

glutamate cysteine ligase, modifier subunit

increases expression

deguelin results in increased expression of GCLM mRNA

NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535

G

growth differentiation factor 15

increases expression

deguelin results in increased expression of GDF15 mRNA

NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055

G

GINS complex subunit 2

decreases expression

deguelin results in decreased expression of GINS2 mRNA

NCBI chr19:48,626,770...48,639,523
Ensembl chr19:48,626,770...48,639,339

G

GINS complex subunit 3

decreases expression

deguelin results in decreased expression of GINS3 mRNA

NCBI chr19:9,420,085...9,428,621
Ensembl chr19:9,420,086...9,428,687

G

glycine decarboxylase

decreases expression

deguelin results in decreased expression of GLDC mRNA

NCBI chr 1:227,883,249...227,962,119
Ensembl chr 1:227,883,249...227,962,097

G

GLI family zinc finger 3

decreases expression

deguelin results in decreased expression of GLI3 mRNA

NCBI chr17:49,438,567...49,709,712
Ensembl chr17:49,438,567...49,709,712

G

glutaredoxin

decreases expression

deguelin results in decreased expression of GLRX mRNA

NCBI chr 2:5,341,873...5,351,686
Ensembl chr 2:5,341,885...5,351,680

G

Gem-interacting protein

decreases expression

deguelin results in decreased expression of GMIP mRNA

NCBI chr16:19,600,723...19,614,459
Ensembl chr16:19,600,723...19,614,027

G

guanosine monophosphate reductase 2

decreases expression

deguelin results in decreased expression of GMPR2 mRNA

NCBI chr15:29,165,421...29,175,933
Ensembl chr15:29,165,783...29,174,935

G

G protein subunit alpha i2

decreases expression

deguelin results in decreased expression of GNAI2 mRNA

NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979

G

glucosamine-6-phosphate deaminase 1

decreases expression

deguelin results in decreased expression of GNPDA1 mRNA

NCBI chr18:30,165,435...30,177,462
Ensembl chr18:30,165,427...30,177,486

G

glutamic-oxaloacetic transaminase 1

increases expression

deguelin results in increased expression of GOT1 mRNA

NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633

G

glypican 1

decreases expression

deguelin results in decreased expression of GPC1 mRNA

NCBI chr 9:93,396,234...93,424,047
Ensembl chr 9:93,396,234...93,424,047

G

growth factor receptor bound protein 10

increases expression

deguelin results in increased expression of GRB10 mRNA

NCBI chr14:86,495,051...86,602,800
Ensembl chr14:86,495,054...86,602,806

G

growth factor receptor bound protein 14

increases expression

deguelin results in increased expression of GRB14 mRNA

NCBI chr 3:49,568,210...49,683,805
Ensembl chr 3:49,568,210...49,683,889

G

glutamate ionotropic receptor AMPA type subunit 2

decreases expression

deguelin results in decreased expression of GRIA2 mRNA

NCBI chr 2:165,949,379...166,069,510
Ensembl chr 2:165,947,521...166,069,510

G

glutamate ionotropic receptor NMDA type subunit 2D

decreases expression

deguelin results in decreased expression of GRIN2D mRNA

NCBI chr 1:96,306,871...96,346,994
Ensembl chr 1:96,308,365...96,344,793

G

glutamate metabotropic receptor 4

decreases expression

deguelin results in decreased expression of GRM4 mRNA

NCBI chr20:5,484,172...5,572,821
Ensembl chr20:5,481,124...5,572,821

G

granulin precursor

decreases expression

deguelin results in decreased expression of GRN mRNA

NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775

G

glycogen synthase kinase 3 beta

decreases phosphorylation

deguelin results in decreased phosphorylation of GSK3B protein

PMID:19336726 PMID:21472727

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

glutathione-disulfide reductase

increases expression

deguelin results in increased expression of GSR mRNA

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

glutathione S-transferase mu 2

decreases expression

deguelin results in decreased expression of GSTM2 mRNA

NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961

G

general transcription factor IIE subunit 2

increases expression

deguelin results in increased expression of GTF2E2 mRNA

NCBI chr16:58,399,307...58,449,467
Ensembl chr16:58,399,107...58,449,371

G

GTP binding protein 8

increases expression

deguelin results in increased expression of GTPBP8 mRNA

NCBI chr11:55,945,778...55,955,743
Ensembl chr11:55,945,795...55,955,635

G

guanylate cyclase 2C

decreases expression

deguelin results in decreased expression of GUCY2C mRNA

NCBI chr 4:169,568,505...169,649,092
Ensembl chr 4:169,568,529...169,649,092

G

H1.0 linker histone

increases expression

deguelin results in increased expression of H1-0 mRNA

NCBI chr 7:110,592,834...110,594,694
Ensembl chr 7:110,592,208...110,594,694

G

H1.2 linker histone, cluster member

increases expression

deguelin results in increased expression of H1-2 mRNA

NCBI chr17:41,391,106...41,392,597
Ensembl chr17:41,388,477...41,392,635

G

H2A.Z variant histone 2

decreases expression

deguelin results in decreased expression of H2AZ2 mRNA

NCBI chr14:81,293,304...81,312,209
Ensembl chr14:81,293,299...81,312,144
Ensembl chr 4:81,293,299...81,312,144
Ensembl chr16:81,293,299...81,312,144

G

H2B clustered histone 12

increases expression

deguelin results in increased expression of H2BC12 mRNA

NCBI chr17:42,485,699...42,486,162

G

H2B clustered histone 3

increases expression

deguelin results in increased expression of H2BC3 mRNA

NCBI chr17:41,380,056...41,380,686

G

HUWE1 associated protein modifying stress responses

increases expression

deguelin results in increased expression of HAPSTR1 mRNA

NCBI chr10:6,746,037...6,774,992
Ensembl chr10:6,746,048...6,774,992

G

hemoglobin alpha, adult chain 3

increases expression

deguelin results in increased expression of HBA2 mRNA

NCBI chr10:15,311,637...15,312,481
Ensembl chr10:15,311,634...15,312,481

G

helicase, lymphoid specific

increases expression

deguelin results in increased expression of HELLS mRNA

NCBI chr 1:236,701,704...236,748,239
Ensembl chr 1:236,701,758...236,746,844

G

homocysteine inducible ER protein with ubiquitin like domain 1

increases expression

deguelin results in increased expression of HERPUD1 mRNA

NCBI chr19:10,598,411...10,609,002
Ensembl chr19:10,598,417...10,618,424

G

hes family bHLH transcription factor 1

increases expression

deguelin results in increased expression of HES1 mRNA

NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192

G

hexosaminidase subunit alpha

decreases expression

deguelin results in decreased expression of HEXA mRNA

NCBI chr 8:59,936,526...59,961,654
Ensembl chr 8:59,936,660...59,962,013

G

hexosaminidase subunit beta

increases expression

deguelin results in increased expression of HEXB mRNA

NCBI chr 2:28,483,997...28,504,165
Ensembl chr 2:28,484,012...28,504,223

G

Hedgehog-interacting protein

increases expression

deguelin results in increased expression of HHIP mRNA

NCBI chr19:27,863,684...27,952,528
Ensembl chr19:27,863,213...27,952,528

G

hypoxia inducible factor 1 subunit alpha

increases degradation
multiple interactions

deguelin results in increased degradation of HIF1A protein
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [deguelin results in increased degradation of HIF1A protein]; deguelin inhibits the reaction [IGF1 protein results in increased expression of HIF1A protein]; deguelin inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; deguelin metabolite inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]

PMID:17764071 PMID:18575727 PMID:19139008 PMID:22745725 PMID:27899277

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

histone cluster 1 H2A family member F

increases expression

deguelin results in increased expression of H2AC8 mRNA

NCBI chr17:41,379,404...41,379,796
Ensembl chr17:41,379,404...41,379,796

G

histone cluster 1 H2A family member H

increases expression

deguelin results in increased expression of H2AC11 mRNA

NCBI chr17:41,384,521...41,385,018

G

histone cluster 1 H2A family like 1

increases expression

deguelin results in increased expression of H2AC6 mRNA

NCBI chr17:42,707,954...42,708,420

G

histone cluster 1 H2B family member D

increases expression

deguelin results in increased expression of H2BC5 mRNA

NCBI chr17:42,792,887...42,793,268

G

high mobility group AT-hook 2

increases expression

deguelin results in increased expression of HMGA2 mRNA

NCBI chr 7:55,877,145...55,998,813
Ensembl chr 7:55,880,112...55,994,784

G

hyaluronan-mediated motility receptor

increases expression

deguelin results in increased expression of HMMR mRNA

NCBI chr10:25,132,933...25,163,029
Ensembl chr10:25,132,977...25,163,060

G

heme oxygenase 1

increases expression

deguelin results in increased expression of HMOX1 mRNA

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

heterogeneous nuclear ribonucleoprotein M

decreases expression

deguelin results in decreased expression of HNRNPM mRNA

NCBI chr 7:14,438,703...14,476,781
Ensembl chr 7:14,438,688...14,476,762

G

homer scaffold protein 2

decreases expression

deguelin results in decreased expression of HOMER2 mRNA

NCBI chr 1:135,558,977...135,659,780
Ensembl chr 1:135,567,414...135,659,772

G

hypoxanthine phosphoribosyltransferase 1

increases expression

deguelin results in increased expression of HPRT1 mRNA

NCBI chr X:132,736,175...132,768,149
Ensembl chr X:132,736,096...132,768,154

G

hydroxysteroid (17-beta) dehydrogenase 11

increases expression

deguelin results in increased expression of HSD17B11 mRNA

NCBI chr14:5,693,304...5,743,157
Ensembl chr14:5,711,964...5,743,161

G

hydroxysteroid (17-beta) dehydrogenase 8

decreases expression

deguelin results in decreased expression of HSD17B8 mRNA

NCBI chr20:4,826,725...4,828,742
Ensembl chr20:4,822,026...4,828,742

G

heat shock protein 90 alpha family class A member 1

increases expression

deguelin results in increased expression of HSP90AA1 mRNA

NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268

G

heat shock protein 90 alpha family class B member 1

increases expression

deguelin results in increased expression of HSP90AB1 mRNA

NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488

G

heat shock protein family A (Hsp70) member 1B

increases expression

deguelin results in increased expression of HSPA1B mRNA

NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240

G

heat shock protein family A (Hsp70) member 4

increases expression

deguelin results in increased expression of HSPA4 mRNA

NCBI chr10:37,408,025...37,449,080
Ensembl chr10:37,408,025...37,449,001

G

heat shock protein family A (Hsp70) member 6 like, pseudogene 1

increases expression

deguelin results in increased expression of HSPA6 mRNA

NCBI chr13:83,273,176...83,274,317

G

heat shock protein family A (Hsp70) member 8

increases expression

deguelin results in increased expression of HSPA8 mRNA

NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259

G

heat shock protein family B (small) member 1

increases expression

deguelin results in increased expression of HSPB1 mRNA

NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743

G

heat shock protein family D (Hsp60) member 1

increases expression

deguelin results in increased expression of HSPD1 mRNA

NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662

G

heat shock protein family E (Hsp10) member 1

increases expression

deguelin results in increased expression of HSPE1 mRNA

NCBI chr 9:56,589,912...56,593,000
Ensembl chr 9:56,589,789...56,593,089

G

hypoxia up-regulated 1

increases expression

deguelin results in increased expression of HYOU1 mRNA

NCBI chr 8:44,706,073...44,718,189
Ensembl chr 8:44,706,263...44,718,186

G

intercellular adhesion molecule 1

multiple interactions

deguelin inhibits the reaction [Oxygen deficiency results in increased expression of ICAM1 mRNA]; deguelin inhibits the reaction [Oxygen deficiency results in increased expression of ICAM1 protein]; deguelin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]

PMID:17015749 PMID:22745725

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

inhibitor of DNA binding 1

decreases expression

deguelin results in decreased expression of ID1 mRNA

NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419

G

isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha

increases expression

deguelin results in increased expression of IDH3A mRNA

NCBI chr 8:54,971,694...54,991,085
Ensembl chr 8:54,971,740...54,991,084

G

interferon-induced protein 44

decreases expression

deguelin results in decreased expression of IFI44 mRNA

NCBI chr 2:240,626,058...240,643,879
Ensembl chr 2:240,626,066...240,643,844

G

interferon-induced protein 44-like

increases expression

deguelin results in increased expression of IFI44L mRNA

NCBI chr 2:240,668,742...240,706,425
Ensembl chr 2:240,668,713...240,706,359

G

interferon induced transmembrane protein 2

decreases expression

deguelin results in decreased expression of IFITM2 mRNA

NCBI chr 1:196,051,539...196,052,719
Ensembl chr 1:196,051,537...196,052,741

G

interferon induced transmembrane protein 3

decreases expression

deguelin results in decreased expression of IFITM3 mRNA

NCBI chr 1:196,111,026...196,112,135
Ensembl chr 1:196,111,043...196,112,203

G

interferon gamma

multiple interactions

deguelin inhibits the reaction [Perfadex results in increased expression of IFNG protein]

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interferon-related developmental regulator 1

increases expression

deguelin results in increased expression of IFRD1 mRNA

NCBI chr 6:57,269,395...57,317,833
Ensembl chr 6:57,269,384...57,288,990

G

interferon-related developmental regulator 2

increases expression

deguelin results in increased expression of IFRD2 mRNA

NCBI chr 8:108,260,969...108,266,191
Ensembl chr 8:108,260,969...108,266,194

G

insulin-like growth factor 1

multiple interactions

deguelin inhibits the reaction [IGF1 protein results in increased expression of HIF1A protein]; deguelin inhibits the reaction [IGF1 protein results in increased expression of VEGFA mRNA]

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

insulin-like growth factor 1 receptor

decreases expression

deguelin metabolite results in decreased expression of IGF1R protein; deguelin results in decreased expression of IGF1R mRNA; deguelin results in decreased expression of IGF1R protein

PMID:19139008 PMID:33512557

NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777

G

insulin-like growth factor binding protein 2

decreases expression

deguelin results in decreased expression of IGFBP2 mRNA

NCBI chr 9:74,415,574...74,442,945
Ensembl chr 9:74,415,546...74,442,937

G

immunoglobulin mu DNA binding protein 2

decreases expression

deguelin results in decreased expression of IGHMBP2 mRNA

NCBI chr 1:200,506,641...200,529,293
Ensembl chr 1:200,506,338...200,529,514

G

Indian hedgehog signaling molecule

increases expression

deguelin results in increased expression of IHH mRNA

NCBI chr 9:76,504,315...76,510,532
Ensembl chr 9:76,504,315...76,510,532

G

IKBKB interacting protein

increases expression

deguelin results in increased expression of IKBIP mRNA

NCBI chr 7:25,579,865...25,598,548
Ensembl chr 7:25,579,832...25,605,162

G

IKAROS family zinc finger 1

decreases expression

deguelin results in decreased expression of IKZF1 mRNA

NCBI chr14:86,255,065...86,340,839
Ensembl chr14:86,255,065...86,342,416

G

interleukin 10

multiple interactions

deguelin inhibits the reaction [Oxygen deficiency results in increased expression of IL10 mRNA]

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 4

multiple interactions

deguelin inhibits the reaction [Oxygen deficiency results in decreased expression of IL4 mRNA]

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 6

multiple interactions

deguelin inhibits the reaction [Perfadex results in decreased expression of IL6 protein]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

internexin neuronal intermediate filament protein, alpha

decreases expression

deguelin results in decreased expression of INA mRNA

NCBI chr 1:245,896,775...245,908,330
Ensembl chr 1:245,896,775...245,908,330

G

importin 5

increases expression

deguelin results in increased expression of IPO5 mRNA

NCBI chr15:97,990,755...98,041,074
Ensembl chr15:98,005,299...98,041,126

G

IQ motif containing GTPase activating protein 1

increases expression

deguelin results in increased expression of IQGAP1 mRNA

NCBI chr 1:134,679,581...134,769,776
Ensembl chr 1:134,679,586...134,769,755

G

integrin subunit alpha M

multiple interactions

[NPM1 protein mutant form results in increased susceptibility to deguelin] which results in increased expression of ITGAM protein

NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503

G

inositol 1,4,5-trisphosphate receptor, type 2

decreases expression

deguelin results in decreased expression of ITPR2 mRNA

NCBI chr 4:179,028,594...179,434,657
Ensembl chr 4:179,027,281...179,404,164

G

jumonji domain containing 6, arginine demethylase and lysine hydroxylase

increases expression

deguelin results in increased expression of JMJD6 mRNA

NCBI chr10:102,041,131...102,047,182
Ensembl chr10:102,041,120...102,047,182

G

Jun proto-oncogene, AP-1 transcription factor subunit

increases phosphorylation

deguelin results in increased phosphorylation of JUN protein

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

JunB proto-oncogene, AP-1 transcription factor subunit

decreases expression

deguelin results in decreased expression of JUNB mRNA

NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035

G

lysine acetyltransferase 6A

increases expression

deguelin results in increased expression of KAT6A mRNA

NCBI chr16:69,084,914...69,165,923
Ensembl chr16:69,084,914...69,163,606

G

potassium inwardly-rectifying channel, subfamily J, member 8

increases expression

deguelin results in increased expression of KCNJ8 mRNA

NCBI chr 4:175,508,908...175,515,829
Ensembl chr 4:175,508,912...175,515,603

G

potassium two pore domain channel subfamily K member 1

decreases expression

deguelin results in decreased expression of KCNK1 mRNA

NCBI chr19:53,959,411...53,997,726
Ensembl chr19:53,959,657...53,997,724

G

potassium channel tetramerization domain containing 9

increases expression

deguelin results in increased expression of KCTD9 mRNA

NCBI chr15:41,942,165...41,969,862
Ensembl chr15:41,942,381...41,969,862

G

lysine demethylase 5B

decreases expression

deguelin results in decreased expression of KDM5B mRNA

NCBI chr13:46,001,589...46,073,868
Ensembl chr13:46,002,542...46,073,872

G

kinase insert domain receptor

decreases expression

deguelin metabolite results in decreased expression of KDR protein; deguelin results in decreased expression of KDR protein

NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018

G

Kelch-like ECH-associated protein 1

increases expression

deguelin results in increased expression of KEAP1 mRNA

NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862

G

KH RNA binding domain containing, signal transduction associated 3

increases expression

deguelin results in increased expression of KHDRBS3 mRNA

NCBI chr 7:100,837,707...100,995,644
Ensembl chr 7:100,837,934...100,988,460

G

kinesin family member 15

increases expression

deguelin results in increased expression of KIF15 mRNA

NCBI chr 8:122,601,888...122,672,750
Ensembl chr 8:122,601,897...122,672,750

G

kinesin family member 20A

increases expression

deguelin results in increased expression of KIF20A mRNA

NCBI chr18:26,230,294...26,238,780
Ensembl chr18:26,230,230...26,238,780

G

kinesin family member 23

increases expression

deguelin results in increased expression of KIF23 mRNA

NCBI chr 8:62,397,908...62,425,162
Ensembl chr 8:62,397,948...62,425,072

G

kinesin family member 2C

increases expression

deguelin results in increased expression of KIF2C mRNA

NCBI chr 5:130,637,347...130,662,680
Ensembl chr 5:130,637,347...130,662,637

G

kinesin family member 5C

decreases expression

deguelin results in decreased expression of KIF5C mRNA

NCBI chr 3:34,032,082...34,185,597
Ensembl chr 3:34,032,105...34,182,413

G

KIT proto-oncogene receptor tyrosine kinase

decreases expression

deguelin results in decreased expression of KIT mRNA

NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652

G

kelch-like family member 24

increases expression

deguelin results in increased expression of KLHL24 mRNA

NCBI chr11:80,843,621...80,877,649
Ensembl chr11:80,846,755...80,877,636

G

kinetochore scaffold 1

increases expression

deguelin results in increased expression of KNL1 mRNA

NCBI chr 3:106,029,627...106,091,915
Ensembl chr 3:106,029,661...106,091,915

G

keratin 17

increases expression

deguelin results in increased expression of KRT17 mRNA

NCBI chr10:85,178,673...85,183,392
Ensembl chr10:85,178,675...85,183,392

G

keratin 18

increases expression
multiple interactions

deguelin results in increased expression of KRT18 protein
deguelin inhibits the reaction [TGFB1 protein results in decreased expression of KRT18 protein]

NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166
Ensembl chr10:133,157,475...133,161,166

G

kinectin 1

increases expression

deguelin results in increased expression of KTN1 mRNA

NCBI chr15:20,913,665...21,002,588
Ensembl chr15:20,914,642...21,002,578

G

L1 cell adhesion molecule

decreases expression

deguelin results in decreased expression of L1CAM mRNA

NCBI chr X:151,597,270...151,623,776
Ensembl chr X:151,597,277...151,623,857

G

laminin subunit gamma 2

decreases expression

deguelin results in decreased expression of LAMC2 mRNA

NCBI chr13:65,284,664...65,344,164
Ensembl chr13:65,284,664...65,344,200

G

lysosomal-associated membrane protein 1

decreases expression

deguelin results in decreased expression of LAMP1 mRNA

NCBI chr16:76,355,982...76,380,700
Ensembl chr16:76,355,984...76,381,883

G

lymphoid enhancer binding factor 1

increases expression

deguelin results in increased expression of LEF1 mRNA

NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794

G

legumain

decreases expression

deguelin results in decreased expression of LGMN mRNA

NCBI chr 6:121,544,048...121,582,495
Ensembl chr 6:121,544,053...121,582,480

G

leiomodin 1

decreases expression

deguelin results in decreased expression of LMOD1 mRNA

NCBI chr13:46,754,048...46,796,186
Ensembl chr13:46,754,033...46,794,900

G

lysyl oxidase

multiple interactions

deguelin inhibits the reaction [Oxygen deficiency results in increased expression of LOX mRNA]

NCBI chr18:45,964,544...45,977,431
Ensembl chr18:45,967,343...46,041,477

G

lysyl oxidase-like 1

decreases expression

deguelin results in decreased expression of LOXL1 mRNA

NCBI chr 8:58,691,763...58,716,365
Ensembl chr 8:58,692,593...58,716,356

G

lysophosphatidic acid receptor 2

decreases expression

deguelin results in decreased expression of LPAR2 mRNA

NCBI chr16:19,592,067...19,599,998
Ensembl chr16:19,595,655...19,599,998

G

LDL receptor related protein 4

increases expression

deguelin results in increased expression of LRP4 mRNA

NCBI chr 3:77,429,600...77,483,593
Ensembl chr 3:77,429,798...77,483,593

G

LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated

increases expression

deguelin results in increased expression of LSM2 mRNA

NCBI chr20:3,843,467...3,847,217
Ensembl chr20:3,843,466...3,847,266

G

lanosterol synthase

decreases expression

deguelin results in decreased expression of LSS mRNA

NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762

G

membrane associated guanylate kinase, WW and PDZ domain containing 1

decreases expression

deguelin results in decreased expression of MAGI1 mRNA

NCBI chr 4:126,205,663...126,811,354
Ensembl chr 4:126,206,816...126,811,691

G

microtubule-associated protein 1B

decreases expression

deguelin results in decreased expression of MAP1B mRNA

NCBI chr 2:30,817,261...30,910,458
Ensembl chr 2:30,817,261...30,910,317

G

microtubule-associated protein 1 light chain 3 beta

increases expression

deguelin results in increased expression of MAP1LC3B mRNA

NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690

G

microtubule-associated protein 2

decreases expression

deguelin results in decreased expression of MAP2 mRNA

NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809

G

mitogen activated protein kinase kinase 1

decreases expression

deguelin metabolite results in decreased expression of MAP2K1 protein; deguelin results in decreased expression of MAP2K1 protein

PMID:19139008 PMID:19336726

NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147

G

mitogen activated protein kinase kinase 2

decreases expression

deguelin results in decreased expression of MAP2K2 protein

NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243

G

mitogen activated protein kinase kinase 7

decreases expression

deguelin results in decreased expression of MAP2K7 protein

NCBI chr12:2,591,312...2,600,534
Ensembl chr12:2,591,219...2,604,222

G

mitogen activated protein kinase kinase kinase 3

affects expression

deguelin affects the expression of MAP3K3 protein

NCBI chr10:91,020,174...91,088,852
Ensembl chr10:91,020,174...91,088,848

G

microtubule-associated protein 6

decreases expression

deguelin results in decreased expression of MAP6 mRNA

NCBI chr 1:153,568,020...153,634,415
Ensembl chr 1:153,568,368...153,634,414

G

mitogen activated protein kinase 1

affects phosphorylation

deguelin affects the phosphorylation of MAPK1 protein

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen-activated protein kinase 12

decreases expression

deguelin results in decreased expression of MAPK12 mRNA

NCBI chr 7:120,206,005...120,216,711
Ensembl chr 7:120,206,271...120,216,664

G

mitogen-activated protein kinase 1 interacting protein 1-like

increases expression

deguelin results in increased expression of MAPK1IP1L mRNA

NCBI chr15:20,545,043...20,571,466
Ensembl chr15:20,545,059...20,569,674

G

mitogen activated protein kinase 3

affects phosphorylation
decreases expression

deguelin affects the phosphorylation of MAPK3 protein
deguelin results in decreased expression of MAPK3 mRNA

PMID:25322282 PMID:33512557

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

microtubule-associated protein, RP/EB family, member 3

decreases expression

deguelin results in decreased expression of MAPRE3 mRNA

NCBI chr 6:25,513,800...25,558,876
Ensembl chr 6:25,513,800...25,558,881

G

myristoylated alanine rich protein kinase C substrate

decreases expression

deguelin results in decreased expression of MARCKS mRNA

NCBI chr20:40,685,315...40,691,012
Ensembl chr20:40,685,315...40,691,012

G

methionine adenosyltransferase 2A

decreases expression

deguelin results in decreased expression of MAT2A mRNA

NCBI chr 4:104,489,877...104,495,447
Ensembl chr 4:104,488,466...104,495,493

G

membrane-bound transcription factor peptidase, site 1

decreases expression

deguelin results in decreased expression of MBTPS1 mRNA

NCBI chr19:47,561,598...47,612,769
Ensembl chr19:47,561,598...47,612,791

G

MCL1 apoptosis regulator, BCL2 family member

decreases expression

deguelin results in decreased expression of MCL1 protein

NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303

G

minichromosome maintenance complex component 3

decreases expression

deguelin results in decreased expression of MCM3 mRNA

NCBI chr 9:23,219,169...23,237,314
Ensembl chr 9:23,219,169...23,237,314

G

mucolipin TRP cation channel 1

decreases expression

deguelin results in decreased expression of MCOLN1 mRNA

NCBI chr12:1,560,341...1,574,252
Ensembl chr12:1,560,359...1,574,252

G

mitochondrial calcium uniporter regulator 1

increases expression

deguelin results in increased expression of MCUR1 mRNA

NCBI chr17:21,142,526...21,159,651
Ensembl chr17:21,141,602...21,159,651

G

MDM2 proto-oncogene

increases expression

deguelin results in increased expression of MDM2 mRNA

NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915

G

malic enzyme 1

increases expression

deguelin results in increased expression of ME1 mRNA

NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304

G

malic enzyme 2

increases expression

deguelin results in increased expression of ME2 mRNA

NCBI chr18:67,350,833...67,400,987
Ensembl chr18:67,355,795...67,400,987

G

meteorin, glial cell differentiation regulator

decreases expression

deguelin results in decreased expression of METRN mRNA

NCBI chr10:14,816,684...14,818,702
Ensembl chr10:14,816,572...14,818,701

G

major facilitator superfamily domain containing 10

decreases expression

deguelin results in decreased expression of MFSD10 mRNA

NCBI chr14:76,103,762...76,107,385
Ensembl chr14:76,103,815...76,107,377

G

major facilitator superfamily domain containing 14A

increases expression

deguelin results in increased expression of MFSD14A mRNA

NCBI chr 2:204,579,174...204,611,600
Ensembl chr 2:204,579,174...204,659,319

G

O-6-methylguanine-DNA methyltransferase

decreases expression

deguelin results in decreased expression of MGMT mRNA

NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756

G

marker of proliferation Ki-67

decreases expression

deguelin results in decreased expression of MKI67 protein

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

MLLT11, transcription factor 7 cofactor

decreases expression

deguelin results in decreased expression of MLLT11 mRNA

NCBI chr 2:182,795,790...182,804,960
Ensembl chr 2:182,795,790...182,797,199

G

matrix metallopeptidase 1

decreases expression

deguelin results in decreased expression of MMP1 protein

NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097

G

matrix metallopeptidase 13

decreases expression

deguelin results in decreased expression of MMP13 protein

NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239

G

matrix metallopeptidase 2

multiple interactions
decreases expression

deguelin results in decreased expression of and results in decreased activity of MMP2 protein
deguelin results in decreased expression of MMP2 mRNA; deguelin results in decreased expression of MMP2 protein

PMID:25322282 PMID:26884827 PMID:33512557

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 7

decreases expression

deguelin results in decreased expression of MMP7 mRNA

NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902

G

matrix metallopeptidase 9

multiple interactions
decreases expression
decreases activity

deguelin inhibits the reaction [TNF protein results in increased expression of MMP9 protein]
deguelin results in decreased expression of MMP9 mRNA; deguelin results in decreased expression of MMP9 protein
deguelin results in decreased activity of MMP9 protein

PMID:17015749 PMID:25322282 PMID:26884827

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

meiotic nuclear divisions 1

increases expression

deguelin results in increased expression of MND1 mRNA

NCBI chr 2:169,433,523...169,496,081
Ensembl chr 2:169,433,540...169,496,096

G

MORN repeat containing 2

decreases expression

deguelin results in decreased expression of MORN2 mRNA

NCBI chr 6:14,718,799...14,725,281

G

mannose receptor, C type 1

multiple interactions

deguelin promotes the reaction [Oxygen deficiency results in increased expression of MRC1 mRNA]

NCBI chr17:77,249,187...77,330,857
Ensembl chr17:77,249,187...77,330,857

G

mitochondrial ribosomal protein L19

increases expression

deguelin results in increased expression of MRPL19 mRNA

NCBI chr 4:114,521,824...114,526,053
Ensembl chr 4:114,521,824...114,526,053

G

mitochondrial ribosomal protein L58

increases expression

deguelin results in increased expression of MRPL58 mRNA

NCBI chr10:100,646,374...100,652,871
Ensembl chr10:100,646,216...100,652,871

G

mitochondrial ribosomal protein S6

decreases expression

deguelin results in decreased expression of MRPS6 mRNA

NCBI chr11:31,295,358...31,348,483
Ensembl chr11:31,295,614...31,348,484

G

mutS homolog 6

increases expression

deguelin results in increased expression of MSH6 mRNA

NCBI chr 6:6,562,631...6,579,995
Ensembl chr 6:6,562,632...6,579,956

G

musashi RNA-binding protein 2

decreases expression

deguelin results in decreased expression of MSI2 mRNA

NCBI chr10:73,143,760...73,510,566
Ensembl chr10:73,147,380...73,510,157

G

mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6

decreases expression

deguelin results in decreased expression of ND6 mRNA

NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
Ensembl chr MT:13,543...14,061

G

metallothionein 1, pseudogene 3

increases expression

deguelin results in increased expression of MT1E mRNA

NCBI chr17:74,786,652...74,787,040
Ensembl chr17:74,786,654...74,787,135

G

metallothionein 2A

increases expression

deguelin results in increased expression of MT2A mRNA

NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784

G

metal response element binding transcription factor 2

increases expression

deguelin results in increased expression of MTF2 mRNA

NCBI chr14:1,639,256...1,683,513
Ensembl chr14:1,640,746...1,683,524

G

methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1

increases expression

deguelin results in increased expression of MTHFD1 mRNA

NCBI chr 6:94,977,862...95,045,375
Ensembl chr 6:94,977,862...95,045,372

G

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase

increases expression

deguelin results in increased expression of MTHFD2 mRNA

NCBI chr 4:115,811,135...115,822,663
Ensembl chr 4:115,811,139...115,822,608

G

mechanistic target of rapamycin kinase

decreases expression
decreases phosphorylation

deguelin metabolite results in decreased expression of MTOR protein; deguelin results in decreased expression of MTOR protein
deguelin results in decreased phosphorylation of MTOR protein

PMID:19139008 PMID:27255535

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

mucin 1, cell surface associated

decreases expression

deguelin results in decreased expression of MUC1 mRNA

NCBI chr 2:174,635,989...174,640,738
Ensembl chr 2:174,635,995...174,640,733

G

MYB proto-oncogene like 1

decreases expression

deguelin results in decreased expression of MYBL1 mRNA

NCBI chr 5:9,582,905...9,618,179
Ensembl chr 5:9,582,934...9,618,183

G

MYC proto-oncogene, bHLH transcription factor

multiple interactions
increases expression
decreases expression

[deguelin results in increased degradation of CTNNB1 protein] which results in decreased expression of MYC protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [deguelin results in decreased expression of MYC protein]; deguelin inhibits the reaction [TNF protein results in increased expression of MYC protein]
deguelin results in increased expression of MYC mRNA
deguelin inhibits the reaction [MYC protein results in increased activity of ODC1 protein]

PMID:9270009 PMID:17015749 PMID:21472727 PMID:33512557

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

myosin, light chain 1

decreases expression

deguelin results in decreased expression of MYL1 mRNA

NCBI chr 9:68,437,514...68,458,256
Ensembl chr 9:68,437,517...68,458,261

G

myosin, light chain 4

decreases expression

deguelin results in decreased expression of MYL4 mRNA

NCBI chr10:89,449,456...89,485,365
Ensembl chr10:89,449,443...89,485,363

G

nicotinamide phosphoribosyltransferase

increases expression

deguelin results in increased expression of NAMPT mRNA

NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100

G

N-acetyltransferase 1

decreases expression

deguelin results in decreased expression of NAT1 mRNA

NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520

G

neuron navigator 1

decreases expression

deguelin results in decreased expression of NAV1 mRNA

NCBI chr13:46,866,972...47,119,368
Ensembl chr13:46,873,689...47,126,449

G

neurocan

decreases expression

deguelin results in decreased expression of NCAN mRNA

NCBI chr16:19,301,969...19,328,436
Ensembl chr16:19,301,969...19,328,436

G

non-SMC condensin I complex, subunit H

increases expression

deguelin results in increased expression of NCAPH mRNA

NCBI chr 3:114,371,937...114,399,178
Ensembl chr 3:114,371,941...114,399,180

G

NCK adaptor protein 1

increases expression

deguelin results in increased expression of NCK1 mRNA

NCBI chr 8:101,018,610...101,079,237
Ensembl chr 8:101,018,702...101,079,300

G

nuclear receptor coactivator 3

decreases expression

deguelin results in decreased expression of NCOA3 mRNA; deguelin results in decreased expression of NCOA3 protein

NCBI chr 3:154,738,566...154,821,395
Ensembl chr 3:154,738,581...154,818,594

G

N-myc downstream regulated 1

decreases expression

deguelin results in decreased expression of NDRG1 mRNA

NCBI chr 7:98,684,487...98,725,869
Ensembl chr 7:98,684,487...98,725,880

G

NADH:ubiquinone oxidoreductase subunit V3

increases expression

deguelin results in increased expression of NDUFV3 mRNA

NCBI chr20:9,612,462...9,621,622
Ensembl chr20:9,612,431...9,623,074
Ensembl chr13:9,612,431...9,623,074

G

neurofilament heavy chain

decreases expression

deguelin results in decreased expression of NEFH mRNA

NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351

G

neurofilament light chain

decreases expression

deguelin results in decreased expression of NEFL mRNA

NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793

G

nei-like DNA glycosylase 3

increases expression

deguelin results in increased expression of NEIL3 mRNA

NCBI chr16:38,359,305...38,418,528
Ensembl chr16:38,359,371...38,418,527

G

NIMA-related kinase 2

decreases expression
increases expression

deguelin results in decreased expression of NEK2 mRNA; deguelin results in decreased expression of NEK2 protein
deguelin results in increased expression of NEK2 mRNA

PMID:28509438 PMID:33512557

NCBI chr13:103,405,818...103,419,063
Ensembl chr13:103,405,819...103,419,051

G

neuronal differentiation 1

increases expression

deguelin results in increased expression of NEUROD1 mRNA

NCBI chr 3:64,359,554...64,363,526
Ensembl chr 3:64,359,395...64,363,649

G

NFE2 like bZIP transcription factor 1

increases expression

deguelin results in increased expression of NFE2L1 mRNA

NCBI chr10:81,796,055...81,812,926
Ensembl chr10:81,800,366...81,832,318

G

NFKB inhibitor alpha

multiple interactions

deguelin inhibits the reaction [TNF protein results in increased degradation of and results in increased phosphorylation of NFKBIA protein]; deguelin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]

PMID:17015749 PMID:22623043 PMID:28529457

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

nischarin

decreases expression

deguelin results in decreased expression of NISCH mRNA

NCBI chr16:6,364,370...6,400,675
Ensembl chr16:6,364,374...6,400,668

G

nucleolar and coiled-body phosphoprotein 1

decreases expression

deguelin results in decreased expression of NOLC1 mRNA

NCBI chr 1:244,921,275...244,932,089
Ensembl chr 1:244,921,377...244,932,088

G

NOP58 ribonucleoprotein

increases expression

deguelin results in increased expression of NOP58 mRNA

NCBI chr 9:61,120,939...61,144,810
Ensembl chr 9:61,120,929...61,144,810

G

nitric oxide synthase 2

decreases expression

deguelin results in decreased expression of NOS2 protein

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

nitric oxide synthase 3

decreases expression
increases expression

deguelin results in decreased expression of NOS3 protein
deguelin results in increased expression of NOS3 mRNA

PMID:19336726 PMID:34642769

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

notch receptor 2

increases expression

deguelin results in increased expression of NOTCH2 mRNA

NCBI chr 2:185,610,594...185,744,088
Ensembl chr 2:185,610,589...185,744,088

G

notch receptor 3

decreases expression

deguelin results in decreased expression of NOTCH3 mRNA

NCBI chr 7:11,132,984...11,184,025
Ensembl chr 7:11,133,706...11,184,025

G

neural proliferation, differentiation and control, 1

decreases expression

deguelin results in decreased expression of NPDC1 mRNA

NCBI chr 3:8,220,446...8,226,446
Ensembl chr 3:8,213,663...8,226,866

G

nucleophosmin 1

decreases expression
multiple interactions
increases response to substance

[deguelin results in decreased expression of NPM1 protein mutant form] which results in decreased expression of CDKN1A protein; [deguelin results in decreased expression of NPM1 protein mutant form] which results in decreased expression of CEBPA protein; [deguelin results in decreased expression of NPM1 protein mutant form] which results in decreased expression of TP53 protein
[NPM1 protein mutant form results in increased susceptibility to deguelin] which results in decreased expression of and results in increased activity of CASP6 protein; [NPM1 protein mutant form results in increased susceptibility to deguelin] which results in decreased expression of and results in increased activity of CASP8 protein; [NPM1 protein mutant form results in increased susceptibility to deguelin] which results in increased cleavage of CASP3 protein; [NPM1 protein mutant form results in increased susceptibility to deguelin] which results in increased cleavage of PARP1 protein; [NPM1 protein mutant form results in increased susceptibility to deguelin] which results in increased expression of CD14 protein; [NPM1 protein mutant form results in increased susceptibility to deguelin] which results in increased expression of ITGAM protein

NCBI chr10:17,741,512...17,751,626
Ensembl chr10:17,739,941...17,751,645
Ensembl chr X:17,739,941...17,751,645

G

neuronal pentraxin 1

decreases expression

deguelin results in decreased expression of NPTX1 mRNA

NCBI chr10:104,811,107...104,820,358
Ensembl chr10:104,811,403...104,820,367

G

NAD(P)H quinone dehydrogenase 1

increases expression

deguelin results in increased expression of NQO1 mRNA

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 2, group F, member 1

decreases expression

deguelin results in decreased expression of NR2F1 mRNA

NCBI chr 2:8,040,375...8,050,123
Ensembl chr 2:8,040,377...8,050,123

G

nuclear receptor subfamily 3, group C, member 1

increases expression

deguelin results in increased expression of NR3C1 mRNA

NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375

G

nuclear receptor subfamily 4, group A, member 2

decreases expression

deguelin results in decreased expression of NR4A2 mRNA

NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877

G

nuclear receptor subfamily 5, group A, member 1

decreases expression

deguelin results in decreased expression of NR5A1 mRNA

NCBI chr 3:22,464,786...22,486,328
Ensembl chr 3:22,465,502...22,486,328

G

NRAS proto-oncogene, GTPase

decreases expression

deguelin results in decreased expression of NRAS mRNA

NCBI chr 2:190,582,885...190,593,509
Ensembl chr 2:190,582,918...190,591,626

G

neuronal cell adhesion molecule

decreases expression

deguelin results in decreased expression of NRCAM mRNA

NCBI chr 6:61,402,813...61,698,536
Ensembl chr 6:61,329,863...61,702,992

G

nuclear receptor interacting protein 1

increases expression

deguelin results in increased expression of NRIP1 mRNA

NCBI chr11:14,895,843...14,979,490
Ensembl chr11:14,895,553...14,981,761

G

neurexin 1

decreases expression

deguelin results in decreased expression of NRXN1 mRNA

NCBI chr 6:3,177,788...4,323,848
Ensembl chr 6:3,177,897...4,322,710

G

neuronal vesicle trafficking associated 1

decreases expression

deguelin results in decreased expression of NSG1 mRNA

NCBI chr14:72,648,771...72,670,521
Ensembl chr14:72,648,741...72,670,514

G

5' nucleotidase, ecto

multiple interactions

deguelin inhibits the reaction [Oxygen deficiency results in increased expression of NT5E protein]

NCBI chr 8:89,271,046...89,314,918
Ensembl chr 8:89,270,696...89,314,881

G

neurotrophic receptor tyrosine kinase 1

decreases expression

deguelin results in decreased expression of NTRK1 mRNA

NCBI chr 2:173,236,961...173,253,806
Ensembl chr 2:173,236,963...173,253,770

G

NudC domain containing 3

decreases expression

deguelin results in decreased expression of NUDCD3 mRNA

NCBI chr14:80,976,330...81,059,183
Ensembl chr14:80,976,328...81,058,962

G

nudix hydrolase 5

decreases expression

deguelin results in decreased expression of NUDT5 mRNA

NCBI chr17:72,435,690...72,459,008
Ensembl chr17:72,435,697...72,459,001

G

nudix hydrolase 9

increases expression

deguelin results in increased expression of NUDT9 mRNA

NCBI chr14:5,675,376...5,693,332
Ensembl chr14:5,675,382...5,693,142

G

NUF2 component of NDC80 kinetochore complex

increases expression

deguelin results in increased expression of NUF2 mRNA

NCBI chr13:81,693,675...81,722,765
Ensembl chr13:81,693,598...81,722,766

G

nucleoporin 85

decreases expression

deguelin results in decreased expression of NUP85 mRNA

NCBI chr10:100,806,482...100,825,029
Ensembl chr10:100,806,437...100,825,043

G

nucleoporin 88

decreases expression

deguelin results in decreased expression of NUP88 mRNA

NCBI chr10:55,667,903...55,692,249
Ensembl chr10:55,667,906...55,692,257

G

nucleoporin 98 and 96 precursor

decreases expression

deguelin results in decreased expression of NUP98 mRNA; deguelin results in decreased expression of NUP98 protein

NCBI chr 1:156,494,423...156,591,415
Ensembl chr 1:156,494,423...156,591,415

G

nuclear VCP-like

increases expression

deguelin results in increased expression of NVL mRNA

NCBI chr13:92,851,023...92,906,749
Ensembl chr13:92,853,650...92,906,049

G

ornithine decarboxylase antizyme 1

increases expression

deguelin results in increased expression of OAZ1 mRNA

NCBI chr 7:8,883,855...8,886,315
Ensembl chr 7:8,883,851...8,886,310

G

ornithine decarboxylase 1

increases activity
multiple interactions

deguelin results in increased activity of ODC1 protein
deguelin inhibits the reaction [MYC protein results in increased activity of ODC1 protein]; deguelin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ODC1 mRNA]

PMID:9270009 PMID:9834970

NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440

G

Opa interacting protein 5

increases expression

deguelin results in increased expression of OIP5 mRNA

NCBI chr 3:106,593,746...106,603,281
Ensembl chr 3:106,593,760...106,603,250

G

olfactomedin-like 2B

decreases expression

deguelin results in decreased expression of OLFML2B mRNA

NCBI chr13:82,869,414...82,906,607
Ensembl chr13:82,869,433...82,906,607

G

one cut homeobox 1

decreases expression

deguelin results in decreased expression of ONECUT1 mRNA

NCBI chr 8:75,599,432...75,633,598
Ensembl chr 8:75,599,740...75,627,277

G

origin recognition complex, subunit 3

decreases expression

deguelin results in decreased expression of ORC3 mRNA

NCBI chr 5:49,123,758...49,181,552
Ensembl chr 5:49,126,955...49,181,633

G

OXA1L, mitochondrial inner membrane protein

increases expression

deguelin results in increased expression of OXA1L mRNA

NCBI chr15:27,813,688...27,821,319
Ensembl chr15:27,813,625...27,821,319

G

purinergic receptor P2X 3

decreases expression

deguelin results in decreased expression of P2RX3 mRNA

NCBI chr 3:70,080,850...70,124,664
Ensembl chr 3:70,080,851...70,125,178

G

platelet-activating factor acetylhydrolase 1b, regulatory subunit 1

increases expression

deguelin results in increased expression of PAFAH1B1 mRNA

NCBI chr10:59,533,042...59,591,808
Ensembl chr10:59,534,117...59,591,808

G

platelet-activating factor acetylhydrolase 1b, catalytic subunit 3

decreases expression

deguelin results in decreased expression of PAFAH1B3 mRNA

NCBI chr 1:80,881,263...80,883,789
Ensembl chr 1:80,881,309...80,883,893

G

poly(A) binding protein interacting protein 1

decreases expression

deguelin results in decreased expression of PAIP1 mRNA

NCBI chr 2:51,523,190...51,550,241
Ensembl chr 2:51,522,921...51,550,241

G

poly (ADP-ribose) polymerase 1

multiple interactions
increases cleavage
increases expression

[NPM1 protein mutant form results in increased susceptibility to deguelin] which results in increased cleavage of PARP1 protein; deguelin inhibits the reaction [TNF protein results in increased cleavage of PARP1 protein]
deguelin results in increased cleavage of PARP1 protein
deguelin metabolite results in increased expression of PARP1 protein modified form; deguelin results in increased expression of PARP1 protein modified form

PMID:17015749 PMID:17035597 PMID:19139008 PMID:22986522 PMID:25242579

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

poly (ADP-ribose) polymerase 2

increases expression

deguelin results in increased expression of PARP2 mRNA

NCBI chr15:24,034,069...24,044,340
Ensembl chr15:24,034,106...24,044,338

G

PDZ binding kinase

increases expression

deguelin results in increased expression of PBK mRNA

NCBI chr15:40,022,873...40,034,014
Ensembl chr15:40,023,002...40,034,014

G

protocadherin alpha 1

decreases expression

deguelin results in decreased expression of PCDHA1 mRNA

Ensembl chr18:28,581,225...28,846,211

G

protocadherin alpha 9

decreases expression

deguelin results in decreased expression of PCDHA9 mRNA

Ensembl chr18:28,581,225...28,846,211

G

phosphodiesterase 1A

decreases expression

deguelin results in decreased expression of PDE1A mRNA

NCBI chr 3:64,745,140...65,025,178
Ensembl chr 3:64,747,269...65,024,874

G

platelet derived growth factor subunit B

decreases expression

deguelin results in decreased expression of PDGFB mRNA

NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984

G

pyruvate dehydrogenase complex, component X

increases expression

deguelin results in increased expression of PDHX mRNA

NCBI chr 3:89,372,248...89,431,779
Ensembl chr 3:89,371,497...89,431,773

G

pyruvate dehydrogenase kinase 1

decreases expression

deguelin metabolite results in decreased expression of PDK1 protein; deguelin results in decreased expression of PDK1 protein

NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038

G

phosphatidylethanolamine binding protein 1

decreases expression

deguelin results in decreased expression of PEBP1 mRNA

NCBI chr12:39,302,864...39,307,064
Ensembl chr12:39,302,840...39,307,862

G

paternally expressed 10

decreases expression

deguelin results in decreased expression of PEG10 mRNA

NCBI chr 4:32,842,441...32,855,639
Ensembl chr 4:32,848,493...32,852,621

G

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4

decreases expression

deguelin results in decreased expression of PFKFB4 mRNA

NCBI chr 8:109,643,558...109,687,006
Ensembl chr 8:109,643,937...109,685,634

G

phosphofructokinase, liver type

decreases expression

deguelin results in decreased expression of PFKL mRNA

NCBI chr20:10,664,285...10,686,324
Ensembl chr20:10,664,272...10,686,315

G

phosphofructokinase, platelet

increases expression

deguelin results in increased expression of PFKP mRNA

NCBI chr17:63,729,743...63,794,026
Ensembl chr17:63,729,780...63,794,018

G

placental growth factor

decreases expression

deguelin results in decreased expression of PGF mRNA

NCBI chr 6:104,816,102...104,826,685
Ensembl chr 6:104,816,104...104,826,685

G

phosphoglycerate kinase 1

decreases expression

deguelin results in decreased expression of PGK1 mRNA

NCBI chr X:71,271,454...71,287,429
Ensembl chr X:71,271,440...71,287,418

G

phosphoglucomutase 1

increases expression

deguelin results in increased expression of PGM1 mRNA

NCBI chr 5:114,595,298...114,654,728
Ensembl chr 5:114,595,293...114,654,728

G

phosphoglycerate dehydrogenase

increases expression

deguelin results in increased expression of PHGDH mRNA

NCBI chr 2:185,906,962...185,936,054
Ensembl chr 2:185,906,966...185,935,944

G

pleckstrin homology-like domain, family A, member 1

decreases expression

deguelin results in decreased expression of PHLDA1 mRNA

NCBI chr 7:46,967,433...46,969,637
Ensembl chr 7:46,967,409...46,969,861

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

decreases expression

deguelin metabolite results in decreased expression of PIK3CA protein; deguelin results in decreased expression of PIK3CA protein

NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032

G

phosphoinositide-3-kinase regulatory subunit 3

decreases expression

deguelin results in decreased expression of PIK3R3 mRNA

NCBI chr 5:129,700,925...129,772,591
Ensembl chr 5:129,701,229...129,772,583

G

PTEN induced kinase 1

decreases expression

deguelin results in decreased expression of PINK1 mRNA

NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635

G

phosphatidylinositol-5-phosphate 4-kinase type 2 beta

decreases expression

deguelin results in decreased expression of PIP4K2B mRNA

NCBI chr10:82,706,016...82,734,938
Ensembl chr10:82,701,098...82,734,938

G

phosphatidylinositol transfer protein, alpha

decreases expression

deguelin results in decreased expression of PITPNA mRNA

NCBI chr10:60,430,712...60,473,564
Ensembl chr10:60,430,748...60,471,342

G

phospholipase C beta 3

decreases expression

deguelin results in decreased expression of PLCB3 mRNA

NCBI chr 1:204,143,257...204,160,384
Ensembl chr 1:204,144,956...204,160,228

G

phospholipase C, gamma 1

increases phosphorylation

deguelin results in increased phosphorylation of PLCG1 protein

NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330

G

perilipin 2

increases expression

deguelin results in increased expression of PLIN2 mRNA

NCBI chr 5:101,156,648...101,211,738
Ensembl chr 5:101,154,411...101,242,319

G

proteolipid protein 2

increases expression

deguelin results in increased expression of PLP2 mRNA

NCBI chr X:14,834,249...14,837,648
Ensembl chr X:14,834,231...14,838,514

G

plastin 1

decreases expression

deguelin results in decreased expression of PLS1 mRNA

NCBI chr 8:96,316,703...96,426,592
Ensembl chr 8:96,317,849...96,385,195

G

DNA polymerase epsilon 3, accessory subunit

increases expression

deguelin results in increased expression of POLE3 mRNA

NCBI chr 5:75,973,941...75,977,175
Ensembl chr 5:75,974,717...75,977,231
Ensembl chr 7:75,974,717...75,977,231

G

RNA polymerase II, I and III subunit E

decreases expression

deguelin results in decreased expression of POLR2E mRNA

NCBI chr 7:9,666,695...9,670,638
Ensembl chr 7:9,666,716...9,670,643

G

RNA polymerase II, I and III subunit H

increases expression

deguelin results in increased expression of POLR2H mRNA

NCBI chr11:80,192,017...80,197,468
Ensembl chr11:80,192,032...80,197,515
Ensembl chr10:80,192,032...80,197,515

G

POP5 homolog, ribonuclease P/MRP subunit

decreases expression

deguelin results in decreased expression of POP5 mRNA

NCBI chr12:41,376,755...41,384,882
Ensembl chr12:41,376,755...41,381,336

G

POU class 4 homeobox 1

decreases expression

deguelin results in decreased expression of POU4F1 mRNA

NCBI chr15:81,253,714...81,260,057
Ensembl chr15:81,257,781...81,259,728

G

POU class 4 homeobox 2

decreases expression

deguelin results in decreased expression of POU4F2 mRNA

NCBI chr19:29,486,686...29,490,327
Ensembl chr19:29,486,686...29,490,327

G

peroxisome proliferator-activated receptor delta

decreases expression

deguelin results in decreased expression of PPARD mRNA

NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968

G

peptidylprolyl isomerase E

increases expression

deguelin results in increased expression of PPIE mRNA

NCBI chr 5:135,406,172...135,419,332
Ensembl chr 5:135,406,176...135,419,235

G

peptidylprolyl isomerase like 1

decreases expression

deguelin results in decreased expression of PPIL1 mRNA

NCBI chr20:7,302,292...7,322,349
Ensembl chr20:7,302,621...7,322,354

G

protein phosphatase 1 catalytic subunit beta

increases expression

deguelin results in increased expression of PPP1CB mRNA

NCBI chr 6:23,958,813...23,992,841
Ensembl chr 6:23,960,998...23,992,824

G

protein phosphatase 1 catalytic subunit gamma

increases expression

deguelin results in increased expression of PPP1CC mRNA

NCBI chr12:34,383,072...34,400,553
Ensembl chr12:34,383,072...34,400,553

G

protein phosphatase 1, regulatory subunit 17

decreases expression

deguelin results in decreased expression of PPP1R17 mRNA

NCBI chr 4:85,213,595...85,230,607
Ensembl chr 4:85,213,887...85,230,603

G

protein phosphatase 1, regulatory (inhibitor) subunit 1B

multiple interactions

deguelin inhibits the reaction [BDNF protein results in increased expression of PPP1R1B protein]

NCBI chr10:83,347,731...83,356,775
Ensembl chr10:83,347,731...83,356,775

G

peroxiredoxin 3

decreases expression

deguelin results in decreased expression of PRDX3 mRNA

NCBI chr 1:260,001,642...260,014,064
Ensembl chr 1:260,001,637...260,014,111

G

PRELI domain containing 3B

increases expression

deguelin results in increased expression of PRELID3B mRNA

NCBI chr 3:163,263,059...163,271,055
Ensembl chr 3:163,262,985...163,271,181

G

protein kinase AMP-activated catalytic subunit alpha 1

increases phosphorylation

deguelin results in increased phosphorylation of PRKAA1 protein

NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978

G

protein kinase cAMP-activated catalytic subunit alpha

decreases expression

deguelin results in decreased expression of PRKACA mRNA

NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430

G

protein kinase cAMP-activated catalytic subunit beta

increases expression

deguelin results in increased expression of PRKACB mRNA

NCBI chr 2:235,636,878...235,726,928
Ensembl chr 2:235,636,885...235,726,198

G

protein kinase cAMP-dependent type I regulatory subunit alpha

decreases expression

deguelin results in decreased expression of PRKAR1A mRNA

NCBI chr10:94,621,042...94,639,534
Ensembl chr10:94,620,039...94,639,041

G

protein kinase, DNA-activated, catalytic subunit

decreases expression

deguelin results in decreased expression of PRKDC mRNA

NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952

G

protein arginine methyltransferase 5

increases expression

deguelin results in increased expression of PRMT5 mRNA

NCBI chr15:27,968,893...27,978,291
Ensembl chr15:27,968,910...27,978,296

G

proline rich 11

increases expression

deguelin results in increased expression of PRR11 mRNA

NCBI chr10:71,898,858...71,943,325
Ensembl chr10:71,901,202...71,921,012

G

proline rich 7 (synaptic)

decreases expression

deguelin results in decreased expression of PRR7 mRNA

NCBI chr17:9,164,375...9,173,669
Ensembl chr17:9,165,269...9,172,536

G

phosphoserine aminotransferase 1

increases expression

deguelin results in increased expression of PSAT1 mRNA

NCBI chr 1:213,196,709...213,218,564
Ensembl chr 1:213,196,709...213,218,682

G

presenilin 1

increases expression

deguelin results in increased expression of PSEN1 mRNA

NCBI chr 6:103,323,052...103,375,088
Ensembl chr 6:103,323,120...103,371,650

G

presenilin 2

decreases expression

deguelin results in decreased expression of PSEN2 mRNA

NCBI chr13:91,967,506...91,993,240
Ensembl chr13:91,967,983...91,993,174

G

proteasome 20S subunit alpha 1

increases expression

deguelin results in increased expression of PSMA1 mRNA

NCBI chr 1:168,442,421...168,453,440
Ensembl chr 1:168,440,936...168,453,472

G

proteasome activator subunit 2

decreases expression

deguelin results in decreased expression of PSME2 mRNA

NCBI chr15:29,078,495...29,082,794
Ensembl chr15:29,078,500...29,082,946

G

prostaglandin-endoperoxide synthase 2

multiple interactions
decreases expression

deguelin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]
deguelin results in decreased expression of PTGS2 protein

PMID:17015749 PMID:25322282

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

protein tyrosine kinase 2

decreases expression
increases expression

deguelin results in decreased expression of PTK2 protein
deguelin results in increased expression of PTK2 mRNA

PMID:25322282 PMID:33512557

NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783

G

protein tyrosine phosphatase, receptor type, F

decreases expression

deguelin results in decreased expression of PTPRF mRNA

NCBI chr 5:131,741,959...131,824,000
Ensembl chr 5:131,742,754...131,810,023

G

RAB31, member RAS oncogene family

decreases expression

deguelin results in decreased expression of RAB31 mRNA

NCBI chr 9:105,246,712...105,382,973
Ensembl chr 9:105,246,709...105,381,253

G

Rab geranylgeranyltransferase subunit beta

increases expression

deguelin results in increased expression of RABGGTB mRNA

NCBI chr 2:242,844,758...242,850,951
Ensembl chr 2:242,844,762...242,851,050

G

Rac family small GTPase 1

decreases expression

deguelin results in decreased expression of RAC1 protein

NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251

G

RAD21 cohesin complex component

increases expression

deguelin results in increased expression of RAD21 mRNA

NCBI chr 7:83,287,867...83,314,810
Ensembl chr 7:83,287,870...83,314,817

G

RAD9 checkpoint clamp component A

decreases expression

deguelin results in decreased expression of RAD9A mRNA

NCBI chr 1:201,488,511...201,553,582
Ensembl chr 1:201,487,136...201,553,608

G

RAS like proto-oncogene A

increases expression

deguelin results in increased expression of RALA mRNA

NCBI chr17:47,092,163...47,145,192
Ensembl chr17:47,092,207...47,144,063

G

ral guanine nucleotide dissociation stimulator

decreases expression

deguelin results in decreased expression of RALGDS mRNA

NCBI chr 3:11,839,686...11,880,059
Ensembl chr 3:11,839,416...11,880,059

G

retinoic acid receptor, alpha

increases expression

deguelin results in increased expression of RARA mRNA

NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142

G

RB transcriptional corepressor 1

decreases expression

deguelin results in decreased expression of RB1 protein

NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302

G

RNA binding motif protein 12B

decreases expression

deguelin results in decreased expression of RBM12B mRNA

NCBI chr 5:25,597,405...25,610,324
Ensembl chr 5:25,590,493...25,611,245

G

RNA binding motif protein 6

increases expression

deguelin results in increased expression of RBM6 mRNA

NCBI chr 8:108,452,687...108,552,783
Ensembl chr 8:108,452,687...108,552,771

G

ring-box 1

decreases expression

deguelin results in decreased expression of RBX1 mRNA

NCBI chr 7:112,976,863...113,001,051
Ensembl chr 7:112,990,835...113,001,051

G

RELA proto-oncogene, NF-kB subunit

decreases expression
decreases phosphorylation
multiple interactions

deguelin results in decreased expression of RELA mRNA; deguelin results in decreased expression of RELA protein
deguelin results in decreased phosphorylation of RELA protein
deguelin inhibits the reaction [TNF protein affects the localization of and results in increased phosphorylation of RELA protein]; deguelin inhibits the reaction [TNF protein results in increased phosphorylation of and affects the localization of RELA protein]

PMID:17015749 PMID:19365708 PMID:22623043 PMID:28529457

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

reelin

decreases expression

deguelin results in decreased expression of RELN mRNA

NCBI chr 4:12,736,177...13,162,956
Ensembl chr 4:12,736,130...13,162,211

G

ras homolog family member A

decreases expression

deguelin results in decreased expression of RHOA mRNA; deguelin results in decreased expression of RHOA protein

NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746

G

ras homolog family member B

decreases expression

deguelin results in decreased expression of RHOB mRNA

NCBI chr 6:31,363,752...31,365,926
Ensembl chr 6:31,363,548...31,366,108

G

ring finger protein 121

decreases expression

deguelin results in decreased expression of RNF121 mRNA

NCBI chr 1:156,377,368...156,439,936
Ensembl chr 1:156,377,364...156,446,826

G

RNA-binding region (RNP1, RRM) containing 3

decreases expression

deguelin results in decreased expression of RNPC3 mRNA

NCBI chr 2:201,432,769...201,457,015
Ensembl chr 2:201,432,684...201,456,747

G

Rho-associated coiled-coil containing protein kinase 1

decreases expression

deguelin results in decreased expression of ROCK1 protein

PMID:25322282 PMID:26884827

NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571

G

ribosomal protein L11

increases expression

deguelin results in increased expression of RPL11 mRNA

NCBI chr 5:148,274,060...148,277,708
Ensembl chr 5:148,274,069...148,277,599

G

ribosomal protein L17

increases expression

deguelin results in increased expression of RPL17 mRNA

NCBI chr18:68,581,141...68,584,253
Ensembl chr18:68,581,098...68,584,253
Ensembl chr 3:68,581,098...68,584,253

G

ribosomal protein L26

increases expression

deguelin results in increased expression of RPL26 mRNA

NCBI chr10:53,610,836...53,613,966
Ensembl chr10:53,610,421...53,613,966

G

ribosomal protein L28

increases expression

deguelin results in increased expression of RPL28 mRNA

NCBI chr 1:69,052,148...69,054,735
Ensembl chr 1:69,053,203...69,055,032

G

ribosomal protein L3

increases expression

deguelin results in increased expression of RPL3 mRNA

NCBI chr 7:111,622,255...111,627,640
Ensembl chr 7:111,621,610...111,636,468

G

ribosomal protein L36

increases expression

deguelin results in increased expression of RPL36 mRNA

NCBI chr 9:1,441,986...1,447,397
Ensembl chr 6:98,809,534...98,809,897
Ensembl chr 5:98,809,534...98,809,897

G

ribosomal protein L4

increases expression

deguelin results in increased expression of RPL4 mRNA

NCBI chr 8:64,671,177...64,676,301
Ensembl chr 8:64,671,160...64,676,306

G

ribosomal protein L8

increases expression

deguelin results in increased expression of RPL8 mRNA

NCBI chr 7:108,626,194...108,628,485
Ensembl chr 7:108,622,324...108,628,482
Ensembl chr 3:108,622,324...108,628,482

G

ribosomal protein L9

increases expression

deguelin results in increased expression of RPL9 mRNA

NCBI chr14:42,893,945...42,897,140
Ensembl chr14:42,893,942...42,897,136
Ensembl chr 3:42,893,942...42,897,136
Ensembl chr 1:42,893,942...42,897,136

G

ribonuclease P/MRP subunit p40

increases expression

deguelin results in increased expression of RPP40 mRNA

NCBI chr17:28,947,752...28,956,788
Ensembl chr17:28,947,734...28,956,788

G

ribosomal protein S13

increases expression

deguelin results in increased expression of RPS13 mRNA

NCBI chr 1:170,572,925...170,575,355
Ensembl chr 1:170,572,921...170,575,355
Ensembl chr 3:170,572,921...170,575,355

G

ribosomal protein S18

increases expression

deguelin results in increased expression of RPS18 mRNA

NCBI chr20:4,931,427...4,935,538
Ensembl chr20:4,931,768...4,938,315

G

ribosomal protein S2

increases expression

deguelin results in increased expression of RPS2 mRNA

NCBI chr10:13,747,316...13,749,165
Ensembl chr10:13,747,301...13,749,163

G

ribosomal protein s25

increases expression

deguelin results in increased expression of RPS25 mRNA

NCBI chr 8:44,733,623...44,735,999
Ensembl chr 8:44,733,029...44,737,271
Ensembl chr 8:44,733,029...44,737,271

G

ribosomal protein S3

increases expression

deguelin results in increased expression of RPS3 mRNA

NCBI chr 1:153,778,363...153,783,663
Ensembl chr 1:153,777,472...153,783,680

G

ribosomal protein S5

increases expression

deguelin results in increased expression of RPS5 mRNA

NCBI chr 1:73,538,776...73,543,073
Ensembl chr 1:73,538,776...73,543,073

G

ribosomal protein S6

decreases expression
decreases phosphorylation

deguelin metabolite results in decreased expression of RPS6 protein; deguelin metabolite results in decreased expression of RPS6 protein modified form; deguelin results in decreased expression of RPS6 protein; deguelin results in decreased expression of RPS6 protein modified form
deguelin results in decreased phosphorylation of RPS6 protein

PMID:19139008 PMID:27255535

NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602

G

ribosomal protein S6 kinase B1

decreases expression
decreases phosphorylation

deguelin metabolite results in decreased expression of RPS6KB1 protein; deguelin results in decreased expression of RPS6KB1 protein
deguelin results in decreased phosphorylation of RPS6KB1 protein

PMID:19139008 PMID:27255535

NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908

G

ribosomal protein S7

increases expression

deguelin results in increased expression of RPS7 mRNA

NCBI chr 6:45,266,200...45,271,064
Ensembl chr 6:45,223,980...45,271,145
Ensembl chr 5:45,223,980...45,271,145

G

ribosomal RNA processing 1B

increases expression

deguelin results in increased expression of RRP1B mRNA

NCBI chr20:10,123,111...10,148,704
Ensembl chr20:10,123,125...10,147,928

G

ribosomal RNA processing 8

increases expression

deguelin results in increased expression of RRP8 mRNA

NCBI chr 1:160,081,092...160,088,709
Ensembl chr 1:160,084,295...160,089,331

G

ribosome biogenesis regulator 1 homolog

increases expression

deguelin results in increased expression of RRS1 mRNA

NCBI chr 5:9,733,486...9,735,119
Ensembl chr 5:9,733,091...9,735,140

G

ribosomal L24 domain containing 1

increases expression

deguelin results in increased expression of RSL24D1 mRNA

NCBI chr 8:73,852,991...73,861,996
Ensembl chr 8:73,852,996...73,862,001

G

reticulon 2

decreases expression

deguelin results in decreased expression of RTN2 mRNA

NCBI chr 1:78,935,056...78,948,069
Ensembl chr 1:78,935,104...78,948,069

G

reticulon 4 interacting protein 1

decreases expression

deguelin results in decreased expression of RTN4IP1 mRNA

NCBI chr20:47,382,251...47,422,747
Ensembl chr20:47,382,234...47,422,338

G

ribitol xylosyltransferase 1

increases expression

deguelin results in increased expression of RXYLT1 mRNA

NCBI chr 7:57,770,841...57,782,695
Ensembl chr 7:57,770,842...57,782,657

G

SATB homeobox 1

decreases expression

deguelin results in decreased expression of SATB1 mRNA

NCBI chr 9:4,677,817...4,773,061
Ensembl chr 9:4,680,920...4,753,251

G

secernin 1

decreases expression

deguelin results in decreased expression of SCRN1 mRNA

NCBI chr 4:83,632,125...83,694,225
Ensembl chr 4:83,632,131...83,693,852

G

sidekick cell adhesion molecule 2

decreases expression

deguelin results in decreased expression of SDK2 mRNA

NCBI chr10:98,824,916...99,102,590
Ensembl chr10:98,828,348...99,101,759

G

selectin E

multiple interactions

deguelin inhibits the reaction [TNF protein results in increased expression of SELE mRNA]

NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741

G

semaphorin 4B

decreases expression

deguelin results in decreased expression of SEMA4B mRNA

NCBI chr 1:134,136,646...134,177,777
Ensembl chr 1:134,149,536...134,177,775

G

SUMO specific peptidase 6

increases expression

deguelin results in increased expression of SENP6 mRNA

NCBI chr 8:80,988,675...81,071,606
Ensembl chr 8:80,989,052...81,067,170

G

selenophosphate synthetase 2

increases expression

deguelin results in increased expression of SEPHS2 mRNA

NCBI chr 1:181,893,146...181,895,464
Ensembl chr 1:181,892,599...181,895,497

G

serpin family B member 3

decreases secretion

deguelin results in decreased secretion of SERPINB3 protein

NCBI chr13:23,274,120...23,280,660
Ensembl chr13:23,274,484...23,313,682

G

sestrin 2

increases expression

deguelin results in increased expression of SESN2 mRNA

NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260

G

secreted frizzled-related protein 2

decreases expression

deguelin results in decreased expression of SFRP2 mRNA

NCBI chr 2:169,089,517...169,097,064
Ensembl chr 2:169,089,517...169,097,063

G

shugoshin 2

increases expression

deguelin results in increased expression of SGO2 mRNA

NCBI chr 9:59,548,605...59,573,229
Ensembl chr 9:59,548,683...59,573,229

G

SH3 domain binding glutamate-rich protein like 3

decreases expression

deguelin results in decreased expression of SH3BGRL3 mRNA

NCBI chr 5:146,354,152...146,355,525
Ensembl chr 5:146,354,152...146,355,331

G

SH3 domain -containing GRB2-like endophilin B1

increases expression

deguelin results in increased expression of SH3GLB1 mRNA

NCBI chr 2:233,750,838...233,784,817
Ensembl chr 2:233,750,838...233,784,784

G

sirtuin 3

decreases expression

deguelin results in decreased expression of SIRT3 mRNA

NCBI chr 1:195,942,066...195,964,472
Ensembl chr 1:195,942,073...195,964,808

G

spindle and kinetochore associated complex subunit 1

increases expression

deguelin results in increased expression of SKA1 mRNA

NCBI chr18:67,794,722...67,805,037
Ensembl chr18:67,794,725...67,805,037

G

SKI8 subunit of superkiller complex

decreases expression

deguelin results in decreased expression of SKIC8 mRNA

NCBI chr 8:55,103,542...55,120,837
Ensembl chr 8:55,103,545...55,120,813

G

S-phase kinase-associated protein 1

decreases expression

deguelin results in decreased expression of SKP1 mRNA

NCBI chr10:36,401,987...36,417,066
Ensembl chr10:36,402,153...36,417,388

G

stem-loop histone mRNA binding protein

increases expression

deguelin results in increased expression of SLBP mRNA

NCBI chr14:77,071,441...77,081,911
Ensembl chr14:77,071,632...77,081,906

G

solute carrier family 11 member 2

decreases expression

deguelin results in decreased expression of SLC11A2 mRNA

NCBI chr 7:131,503,076...131,540,246
Ensembl chr 7:131,503,081...131,540,145

G

solute carrier family 17 member 6

decreases expression

deguelin results in decreased expression of SLC17A6 mRNA

NCBI chr 1:101,212,489...101,252,543
Ensembl chr 1:101,212,489...101,252,542

G

solute carrier family 1 member 2

decreases expression

deguelin results in decreased expression of SLC1A2 mRNA

NCBI chr 3:89,005,129...89,135,469
Ensembl chr 3:89,005,129...89,126,498

G

solute carrier family 25 member 4

decreases expression

deguelin results in decreased expression of SLC25A4 mRNA

NCBI chr16:46,072,935...46,076,730
Ensembl chr16:46,072,939...46,076,733

G

solute carrier family 25 member 5, pseudogene 11

increases expression

deguelin results in increased expression of SLC25A6 mRNA

NCBI chr18:68,571,222...68,572,461
Ensembl chr18:68,571,300...68,572,199

G

solute carrier family 2 member 1

increases expression

deguelin results in increased expression of SLC2A1 mRNA

NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416

G

solute carrier family 2 member 6

decreases expression

deguelin results in decreased expression of SLC2A6 mRNA

NCBI chr 3:10,348,395...10,355,208
Ensembl chr 3:10,348,395...10,355,208

G

solute carrier family 30 member 1

increases expression

deguelin results in increased expression of SLC30A1 mRNA

NCBI chr13:103,491,037...103,494,910
Ensembl chr13:103,491,037...103,494,910

G

solute carrier family 35, member A5

decreases expression

deguelin results in decreased expression of SLC35A5 mRNA

NCBI chr11:55,653,376...55,674,476
Ensembl chr11:55,653,394...55,674,473

G

solute carrier family 35, member F2

increases expression

deguelin results in increased expression of SLC35F2 mRNA

NCBI chr 8:54,159,970...54,203,614
Ensembl chr 8:54,159,970...54,203,612

G

solute carrier family 38, member 1

increases expression

deguelin results in increased expression of SLC38A1 mRNA

NCBI chr 7:127,733,230...127,802,541
Ensembl chr 7:127,738,226...127,802,218

G

solute carrier family 3 member 2

increases expression

deguelin results in increased expression of SLC3A2 mRNA

NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931

G

solute carrier family 6 member 3

decreases expression

deguelin results in decreased expression of SLC6A3 mRNA

NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413

G

solute carrier family 7 member 5

increases expression

deguelin results in increased expression of SLC7A5 mRNA

NCBI chr19:49,935,220...49,963,823
Ensembl chr19:49,935,220...49,963,823

G

slit guidance ligand 2

decreases expression

deguelin results in decreased expression of SLIT2 mRNA

NCBI chr14:62,616,337...62,955,934
Ensembl chr14:62,617,067...62,955,948

G

SLIT and NTRK-like family, member 1

decreases expression

deguelin results in decreased expression of SLITRK1 mRNA

NCBI chr15:85,723,252...85,727,290
Ensembl chr15:85,724,475...85,727,509

G

SMAD family member 3

decreases phosphorylation

deguelin results in decreased phosphorylation of SMAD3 protein

NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960

G

SMAD family member 4

multiple interactions

deguelin inhibits the reaction [TGFB1 protein affects the localization of SMAD4 protein]

NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438

G

SMAD family member 5

increases expression

deguelin results in increased expression of SMAD5 mRNA

NCBI chr17:7,862,332...7,891,678
Ensembl chr17:7,864,720...7,891,634

G

SWI/SNF related BAF chromatin remodeling complex subunit C1

increases expression

deguelin results in increased expression of SMARCC1 mRNA

NCBI chr 8:110,111,097...110,214,734
Ensembl chr 8:110,111,122...110,214,720

G

structural maintenance of chromosomes 1A

decreases expression

deguelin results in decreased expression of SMC1A mRNA

NCBI chr X:21,103,323...21,148,053
Ensembl chr X:21,103,282...21,148,056

G

structural maintenance of chromosomes 3

increases expression

deguelin results in increased expression of SMC3 mRNA

NCBI chr 1:252,601,422...252,644,522
Ensembl chr 1:252,601,753...252,644,522

G

structural maintenance of chromosomes 4

increases expression

deguelin results in increased expression of SMC4 mRNA

NCBI chr 2:153,240,243...153,268,722
Ensembl chr 2:153,240,283...153,271,571

G

snail family transcriptional repressor 1

decreases expression
multiple interactions

deguelin results in decreased expression of SNAI1 mRNA; deguelin results in decreased expression of SNAI1 protein
deguelin inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 protein]

PMID:19861542 PMID:22986522

NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969

G

snail family transcriptional repressor 2

increases expression

deguelin results in increased expression of SNAI2 mRNA

NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200

G

synaptosome associated protein 25

decreases expression

deguelin results in decreased expression of SNAP25 mRNA

NCBI chr 3:124,041,898...124,123,761
Ensembl chr 3:124,041,898...124,123,760

G

synuclein alpha

decreases expression

deguelin results in decreased expression of SNCA mRNA

NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262

G

suppressor of cytokine signaling 2

decreases expression

deguelin results in decreased expression of SOCS2 mRNA

NCBI chr 7:30,006,360...30,045,161
Ensembl chr 7:30,008,578...30,043,548

G

SOS Ras/Rac guanine nucleotide exchange factor 1

decreases expression

deguelin results in decreased expression of SOS1 protein

NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107

G

SRY-box transcription factor 14

increases expression

deguelin results in increased expression of SOX14 mRNA

NCBI chr 8:100,421,982...100,423,918
Ensembl chr 8:100,421,982...100,423,918

G

SRY-box transcription factor 30

increases expression

deguelin results in increased expression of SOX30 mRNA

NCBI chr10:30,417,499...30,446,441
Ensembl chr10:30,418,473...30,446,453

G

SRY-box transcription factor 5

increases expression

deguelin results in increased expression of SOX5 mRNA

NCBI chr 4:176,781,375...177,736,833
Ensembl chr 4:176,785,892...177,736,852

G

sperm associated antigen 5

increases expression

deguelin results in increased expression of SPAG5 mRNA

NCBI chr10:63,198,717...63,216,746
Ensembl chr10:63,198,768...63,216,745

G

SAM pointed domain containing ets transcription factor

decreases expression

deguelin results in decreased expression of SPDEF mRNA

NCBI chr20:5,771,440...5,785,893
Ensembl chr20:5,771,441...5,785,893

G

speckle type BTB/POZ protein like

increases expression

deguelin results in increased expression of SPOPL mRNA

NCBI chr 3:6,074,681...6,148,508
Ensembl chr 3:6,078,310...6,108,794

G

sprouty-related, EVH1 domain containing 2

increases expression

deguelin results in increased expression of SPRED2 mRNA

NCBI chr14:94,149,210...94,250,787
Ensembl chr14:94,148,837...94,249,162

G

sequestosome 1

increases expression

deguelin results in increased expression of SQSTM1 mRNA

NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673

G

SRC proto-oncogene, non-receptor tyrosine kinase

increases activity

deguelin metabolite results in increased activity of SRC protein; deguelin results in increased activity of SRC protein

NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476

G

signal recognition particle 72

increases expression

deguelin results in increased expression of SRP72 mRNA

NCBI chr14:31,168,175...31,195,717
Ensembl chr14:31,168,293...31,195,729

G

serine and arginine rich splicing factor 10

increases expression

deguelin results in increased expression of SRSF10 mRNA

NCBI chr 5:148,088,759...148,102,964
Ensembl chr 5:148,088,823...148,101,768

G

small RNA binding exonuclease protection factor La

increases expression

deguelin results in increased expression of SSB mRNA

NCBI chr 3:54,616,616...54,626,203
Ensembl chr 3:54,616,619...54,626,203

G

signal sequence receptor subunit 1

decreases expression

deguelin results in decreased expression of SSR1 mRNA

NCBI chr17:26,833,720...26,861,821
Ensembl chr17:26,833,741...26,861,821

G

somatostatin

decreases expression

deguelin results in decreased expression of SST mRNA

NCBI chr11:76,956,896...76,958,173
Ensembl chr11:76,956,896...76,958,173

G

signal transducer and activator of transcription 3

increases activity

deguelin metabolite results in increased activity of STAT3 protein; deguelin results in increased activity of STAT3 protein

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

signal transducer and activator of transcription 4

decreases expression

deguelin results in decreased expression of STAT4 mRNA

NCBI chr 9:49,472,660...49,588,540
Ensembl chr 9:49,419,340...49,588,540

G

signal transducer and activator of transcription 6

increases phosphorylation

deguelin metabolite results in increased phosphorylation of STAT6 protein; deguelin results in increased phosphorylation of STAT6 protein

NCBI chr 7:63,480,229...63,497,551
Ensembl chr 7:63,479,642...63,498,495

G

serine/threonine kinase 25

decreases expression

deguelin results in decreased expression of STK25 mRNA

NCBI chr 9:94,161,834...94,174,095
Ensembl chr 9:94,161,836...94,174,244

G

steroid sulfatase

multiple interactions

deguelin inhibits the reaction [Tretinoin results in increased activity of STS protein]

NCBI chr X:42,225,131...42,233,403
Ensembl chr X:42,225,372...42,233,402

G

syntaxin binding protein 1

decreases expression

deguelin results in decreased expression of STXBP1 mRNA

NCBI chr 3:16,076,725...16,138,431
Ensembl chr 3:16,076,391...16,138,369

G

sulfatase 1

decreases expression

deguelin results in decreased expression of SULF1 mRNA

NCBI chr 5:6,362,894...6,526,174
Ensembl chr 5:6,362,911...6,525,584

G

sulfotransferase family 1A member 1

decreases expression

deguelin results in decreased expression of SULT1A1 mRNA

NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562

G

Suv3 like RNA helicase

increases expression

deguelin results in increased expression of SUPV3L1 mRNA

NCBI chr20:30,378,542...30,399,076
Ensembl chr20:30,378,550...30,399,054

G

SUV39H1 histone lysine methyltransferase

decreases expression

deguelin results in decreased expression of SUV39H1 mRNA

NCBI chr X:14,421,028...14,433,993
Ensembl chr X:14,421,109...14,433,982

G

SUV39H1 histone lysine methyltransferase, pseudogene 1

decreases expression

deguelin results in decreased expression of SUV39H1 mRNA

NCBI chr X:141,792,589...141,795,257

G

synaptophysin

decreases expression

deguelin results in decreased expression of SYP mRNA

NCBI chr X:14,849,444...14,864,553
Ensembl chr X:14,849,444...14,864,745

G

synaptophysin-like 1

increases expression

deguelin results in increased expression of SYPL1 mRNA

NCBI chr 6:49,565,111...49,585,205
Ensembl chr 6:49,565,154...49,585,330

G

synaptotagmin 1

decreases expression

deguelin results in decreased expression of SYT1 mRNA

NCBI chr 7:43,813,204...44,358,020
Ensembl chr 7:43,815,785...44,357,803

G

synaptotagmin-like 1

increases expression

deguelin results in increased expression of SYTL1 mRNA

NCBI chr 5:145,452,524...145,462,940
Ensembl chr 5:145,422,669...145,462,940

G

transforming, acidic coiled-coil containing protein 3

increases expression

deguelin results in increased expression of TACC3 mRNA

NCBI chr14:77,051,209...77,065,343
Ensembl chr14:77,051,215...77,065,219

G

TATA-box binding protein associated factor 7

increases expression

deguelin results in increased expression of TAF7 mRNA

NCBI chr18:29,459,937...29,462,086
Ensembl chr18:29,452,943...29,462,134

G

TATA-box binding protein associated factor 9

increases expression

deguelin results in increased expression of TAF9 mRNA

NCBI chr 2:31,794,316...31,798,324
Ensembl chr 2:31,794,142...31,798,769

G

transgelin

increases expression

deguelin results in increased expression of TAGLN mRNA

NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668

G

TAP binding protein

decreases expression

deguelin results in decreased expression of TAPBP mRNA

NCBI chr20:4,956,937...4,966,191
Ensembl chr20:4,956,937...4,966,181

G

TBC1 domain family member 9B

decreases expression

deguelin results in decreased expression of TBC1D9B mRNA

NCBI chr10:34,459,930...34,497,146
Ensembl chr10:34,459,953...34,497,145

G

TATA-box binding protein like 1

increases expression

deguelin results in increased expression of TBPL1 mRNA

NCBI chr 1:22,777,892...22,803,305
Ensembl chr 1:22,778,459...22,803,122
Ensembl chr 1:22,778,459...22,803,122

G

transcription factor 4

increases expression
decreases expression

deguelin results in increased expression of TCF4 mRNA
deguelin results in decreased expression of TCF4 mRNA

PMID:19861542 PMID:33512557

NCBI chr18:62,941,739...63,288,126
Ensembl chr18:62,943,782...63,284,425

G

T-cell leukemia translocation altered

decreases expression

deguelin results in decreased expression of TCTA mRNA

NCBI chr 8:108,988,588...108,992,324
Ensembl chr 8:108,988,590...108,991,564

G

tectonic family member 1

decreases expression

deguelin results in decreased expression of TCTN1 mRNA

NCBI chr12:34,309,795...34,347,190
Ensembl chr12:34,309,897...34,342,267

G

telomerase reverse transcriptase

decreases expression

deguelin results in decreased expression of TERT mRNA

NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561

G

transcription factor Dp-1

decreases expression

deguelin results in decreased expression of TFDP1 mRNA

NCBI chr16:76,162,040...76,200,871
Ensembl chr16:76,162,043...76,200,817

G

transforming growth factor, beta 1

multiple interactions
increases expression

deguelin inhibits the reaction [TGFB1 protein affects the localization of SMAD4 protein]; deguelin inhibits the reaction [TGFB1 protein results in decreased expression of KRT18 protein]; deguelin inhibits the reaction [TGFB1 protein results in increased expression of CDH1 protein]; deguelin inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 protein]
deguelin results in increased expression of TGFB1 mRNA

PMID:22986522 PMID:33512557

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

transforming growth factor, beta 3

decreases expression

deguelin results in decreased expression of TGFB3 mRNA

NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564

G

transforming growth factor, beta receptor 2

decreases expression

deguelin results in decreased expression of TGFBR2 mRNA

NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228

G

TIMP metallopeptidase inhibitor 1

increases expression

deguelin results in increased expression of TIMP1 protein

NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664

G

TIMP metallopeptidase inhibitor 2

increases expression

deguelin results in increased expression of TIMP2 protein

NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611

G

TM2 domain containing 2

decreases expression

deguelin results in decreased expression of TM2D2 mRNA

NCBI chr16:67,016,683...67,022,206
Ensembl chr16:67,012,675...67,022,226

G

transmembrane 9 superfamily member 3

decreases expression

deguelin results in decreased expression of TM9SF3 mRNA

NCBI chr 1:240,032,060...240,085,125
Ensembl chr 1:240,035,003...240,084,776

G

transmembrane protein 126A

increases expression

deguelin results in increased expression of TMEM126A mRNA

NCBI chr 1:144,424,481...144,430,730
Ensembl chr 1:144,422,703...144,430,628