serpentine asbestos - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	serpentine asbestos	go back to main search page
Accession:	CHEBI:46680	browse the term
Synonyms:	related_synonym:	White asbestos
	xref:	CAS:132207-32-0
	xref_mesh:	MESH:D017632

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Rat (772) Mouse (796) Human (825) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (4) Green Monkey (0) Naked Mole-rat (0) All
Genes (772)

serpentine asbestos

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

apoptosis-associated tyrosine kinase

decreases methylation

Asbestos, Serpentine results in decreased methylation of AATK promoter

NCBI chr10:105,290,752...105,327,219
Ensembl chr10:105,291,585...105,327,112

G

ABR activator of RhoGEF and GTPase

decreases methylation

Asbestos, Serpentine results in decreased methylation of ABR promoter

NCBI chr10:61,262,516...61,461,331
Ensembl chr10:61,262,516...61,461,505

G

acyl-CoA synthetase bubblegum family member 1

increases expression

Asbestos, Serpentine results in increased expression of ACSBG1 mRNA

NCBI chr 8:54,991,294...55,047,276
Ensembl chr 8:54,991,296...55,047,391

G

actin alpha 2, smooth muscle

multiple interactions
increases expression
decreases expression

TGFB1 protein affects the reaction [Asbestos, Serpentine results in increased expression of ACTA2 protein]
Asbestos, Serpentine results in increased expression of ACTA2 mRNA; Asbestos, Serpentine results in increased expression of ACTA2 protein
Asbestos, Serpentine results in decreased expression of ACTA2 mRNA

PMID:24160326 PMID:26685284 PMID:29523930 PMID:30609805

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

actin, beta

increases expression
multiple interactions

Asbestos, Serpentine results in increased expression of ACTB mRNA
Asbestos, Serpentine results in increased expression of and results in increased phosphorylation of ACTB protein

NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877

G

actin gamma 2, smooth muscle

decreases expression

Asbestos, Serpentine results in decreased expression of ACTG2 mRNA

NCBI chr 4:116,021,832...116,046,475
Ensembl chr 4:116,021,832...116,046,465

G

actinin alpha 2

increases methylation

Asbestos, Serpentine results in increased methylation of ACTN2 5' UTR

NCBI chr17:58,143,334...58,210,622
Ensembl chr17:58,142,625...58,210,622

G

ADAM metallopeptidase with thrombospondin type 1 motif, 2

increases expression
multiple interactions

Asbestos, Serpentine results in increased expression of ADAMTS2 mRNA
SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in increased expression of ADAMTS2 mRNA]

NCBI chr10:34,920,992...35,126,465
Ensembl chr10:34,921,049...35,123,821

G

ADAM metallopeptidase with thrombospondin type 1 motif, 5

increases expression

Asbestos, Serpentine results in increased expression of ADAMTS5 mRNA

NCBI chr11:25,000,627...25,047,205
Ensembl chr11:25,000,637...25,047,205

G

ADAM metallopeptidase with thrombospondin type 1 motif, 9

increases expression

Asbestos, Serpentine results in increased expression of ADAMTS9 mRNA

NCBI chr 4:125,290,633...125,462,988
Ensembl chr 4:125,291,490...125,462,929

G

adenosine deaminase RNA specific B2

increases methylation

Asbestos, Serpentine results in increased methylation of ADARB2 gene

NCBI chr17:61,750,437...62,300,984
Ensembl chr17:61,756,067...62,300,831

G

ADCYAP receptor type I

decreases methylation

Asbestos, Serpentine results in decreased methylation of ADCYAP1R1 5' UTR

NCBI chr 4:84,593,558...84,642,700
Ensembl chr 4:84,593,892...84,642,700

G

adhesion G protein-coupled receptor G1

decreases expression

Asbestos, Serpentine results in decreased expression of ADGRG1 mRNA

NCBI chr19:10,003,963...10,041,122
Ensembl chr19:10,003,975...10,041,108

G

adiponectin, C1Q and collagen domain containing

decreases expression

Asbestos, Serpentine results in decreased expression of ADIPOQ mRNA

NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564

G

adrenomedullin

increases expression

Asbestos, Serpentine results in increased expression of ADM mRNA

NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654

G

ALF transcription elongation factor 3

increases expression

Asbestos, Serpentine results in increased expression of AFF3 mRNA

NCBI chr 9:40,399,099...40,856,716
Ensembl chr 9:40,404,375...40,857,247

G

anterior gradient 2, protein disulphide isomerase family member

increases expression

Asbestos, Serpentine results in increased expression of AGR2 mRNA

NCBI chr 6:52,708,602...52,729,378
Ensembl chr 6:52,708,602...52,729,371

G

A-kinase anchoring protein 12

increases expression

Asbestos, Serpentine results in increased expression of AKAP12 mRNA

PMID:21148743 PMID:29523930

NCBI chr 1:40,730,123...40,819,863
Ensembl chr 1:40,730,123...40,819,886

G

AKT serine/threonine kinase 1

increases phosphorylation

Asbestos, Serpentine results in increased phosphorylation of AKT1 protein

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

alpha-kinase 2

decreases expression

Asbestos, Serpentine results in decreased expression of ALPK2 mRNA

NCBI chr18:58,775,603...58,906,150
Ensembl chr18:58,775,605...58,906,258

G

autophagy and beclin 1 regulator 1

decreases methylation

Asbestos, Serpentine results in decreased methylation of AMBRA1 gene

NCBI chr 3:77,700,936...77,890,221
Ensembl chr 3:77,700,936...77,890,221

G

adhesion molecule with Ig like domain 2

affects expression
decreases methylation

Asbestos, Serpentine affects the expression of AMIGO2 mRNA
Asbestos, Serpentine results in decreased methylation of AMIGO2 5' UTR

PMID:24160326 PMID:29523930

NCBI chr 7:128,391,493...128,394,589
Ensembl chr 7:128,390,412...128,394,695

G

angiopoietin-like 4

increases expression

Asbestos, Serpentine results in increased expression of ANGPTL4 mRNA

NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519

G

ankyrin repeat and death domain containing 1A

decreases expression

Asbestos, Serpentine results in decreased expression of ANKDD1A mRNA

NCBI chr 8:66,017,571...66,043,738
Ensembl chr 8:66,017,773...66,042,651

G

ankyrin repeat domain containing 11

decreases methylation

Asbestos, Serpentine results in decreased methylation of ANKRD11 promoter

NCBI chr19:50,940,284...51,098,962
Ensembl chr19:50,940,299...51,098,962

G

ankyrin repeat domain 52

decreases methylation

Asbestos, Serpentine results in decreased methylation of ANKRD52 promoter

NCBI chr 7:806,829...820,481
Ensembl chr 7:806,767...820,481

G

ankyrin repeat domain 53

increases methylation

Asbestos, Serpentine results in increased methylation of ANKRD53 5' UTR

NCBI chr 4:116,245,561...116,253,018
Ensembl chr 4:116,246,955...116,253,017

G

acidic nuclear phosphoprotein 32 family member A

increases methylation

Asbestos, Serpentine results in increased methylation of ANP32A gene

NCBI chr 8:62,829,099...62,865,443
Ensembl chr 8:62,827,456...62,865,443

G

alanyl aminopeptidase, membrane

increases expression

Asbestos, Serpentine results in increased expression of ANPEP mRNA

NCBI chr 1:133,767,332...133,810,137
Ensembl chr 1:133,767,332...133,785,789

G

annexin A8

decreases expression

Asbestos, Serpentine results in decreased expression of ANXA8 mRNA

NCBI chr16:9,397,144...9,412,072
Ensembl chr16:9,397,113...9,412,043

G

apolipoprotein C1

decreases expression

Asbestos, Serpentine results in decreased expression of APOC1 mRNA

NCBI chr 1:79,347,057...79,350,340
Ensembl chr 1:79,346,136...79,350,375

G

aquaporin 9

increases expression

Asbestos, Serpentine results in increased expression of AQP9 mRNA

NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395

G

amphiregulin

increases expression
multiple interactions

Asbestos, Serpentine results in increased expression of AREG mRNA
SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in increased expression of AREG mRNA]

NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535

G

ADP-ribosylation factor GTPase activating protein 3

affects expression

Asbestos, Serpentine affects the expression of ARFGAP3 mRNA

NCBI chr 7:114,432,873...114,479,206
Ensembl chr 7:114,432,873...114,479,208

G

Rho GTPase activating protein 21

increases methylation

Asbestos, Serpentine results in increased methylation of ARHGAP21 5' UTR

NCBI chr17:83,348,673...83,472,202
Ensembl chr17:83,348,673...83,472,444

G

Rho GTPase activating protein 42

decreases methylation

Asbestos, Serpentine results in decreased methylation of ARHGAP42 5' UTR

NCBI chr 8:6,154,759...6,384,497
Ensembl chr 8:6,156,865...6,384,870

G

Rho guanine nucleotide exchange factor 17

decreases methylation

Asbestos, Serpentine results in decreased methylation of ARHGEF17 promoter

NCBI chr 1:155,230,607...155,290,163
Ensembl chr 1:155,233,168...155,290,498

G

Rho guanine nucleotide exchange factor 4

decreases methylation

Asbestos, Serpentine results in decreased methylation of ARHGEF4 promoter

NCBI chr 9:36,861,800...37,005,079
Ensembl chr 9:36,861,835...37,005,075

G

achaete-scute family bHLH transcription factor 2

decreases methylation

Asbestos, Serpentine results in decreased methylation of ASCL2 3' UTR

NCBI chr 1:198,148,999...198,151,406
Ensembl chr 1:198,148,999...198,151,406

G

asparaginase and isoaspartyl peptidase 1

decreases expression

Asbestos, Serpentine results in decreased expression of ASRGL1 mRNA

NCBI chr 1:206,006,103...206,027,115
Ensembl chr 1:206,006,109...206,027,108

G

activating transcription factor 3

increases expression

Asbestos, Serpentine results in increased expression of ATF3 mRNA

NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631

G

activating transcription factor 6

increases expression

Asbestos, Serpentine results in increased expression of ATF6 protein

NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177

G

atlastin GTPase 3

decreases expression

Asbestos, Serpentine results in decreased expression of ATL3 mRNA

NCBI chr 1:204,680,958...204,727,360
Ensembl chr 1:204,680,968...204,723,354

G

ATPase plasma membrane Ca2+ transporting 1

increases expression

Asbestos, Serpentine results in increased expression of ATP2B1 mRNA

NCBI chr 7:33,735,595...33,845,226
Ensembl chr 7:33,735,871...33,843,295

G

aurora kinase C

decreases methylation

Asbestos, Serpentine results in decreased methylation of AURKC promoter

NCBI chr 1:66,843,653...66,849,775
Ensembl chr 1:66,843,653...66,864,386

G

Axl receptor tyrosine kinase

increases expression

Asbestos, Serpentine results in increased expression of AXL mRNA

NCBI chr 1:81,265,088...81,296,278
Ensembl chr 1:81,265,088...81,296,265

G

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5

increases expression

Asbestos, Serpentine results in increased expression of B3GNT5 mRNA

NCBI chr11:81,141,102...81,153,206
Ensembl chr11:81,140,599...81,156,166

G

BARX homeobox 1

decreases methylation

Asbestos, Serpentine results in decreased methylation of BARX1 promoter

NCBI chr17:15,990,412...15,993,887
Ensembl chr17:15,990,412...15,993,887

G

BCL2 associated X, apoptosis regulator

increases expression

Asbestos, Serpentine results in increased expression of BAX

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

Bardet-Biedl syndrome 12

affects methylation

Asbestos, Serpentine affects the methylation of BBS12 5' UTR

NCBI chr 2:120,203,396...120,221,024
Ensembl chr 2:120,203,428...120,219,255

G

BCAR3 adaptor protein, NSP family member

decreases expression

Asbestos, Serpentine results in decreased expression of BCAR3 mRNA

NCBI chr 2:210,525,260...210,638,674
Ensembl chr 2:210,525,260...210,638,798

G

BCAS3, microtubule associated cell migration factor

decreases methylation

Asbestos, Serpentine results in decreased methylation of BCAS3 gene

NCBI chr10:70,213,710...70,673,080
Ensembl chr10:70,214,098...70,673,080

G

BCL2, apoptosis regulator

multiple interactions
affects response to substance

[Asbestos, Serpentine results in decreased susceptibility to Asbestos, Serpentine] which results in increased expression of BCL2 mRNA; [Asbestos, Serpentine results in decreased susceptibility to Asbestos, Serpentine] which results in increased expression of BCL2 protein
BCL2 protein affects the susceptibility to Asbestos, Serpentine

PMID:16850164 PMID:22608188

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 11

decreases expression
multiple interactions

Asbestos, Serpentine results in decreased expression of BCL2L11 protein
PRKD1 protein affects the reaction [Asbestos, Serpentine results in decreased expression of BCL2L11 protein]; U 0126 promotes the reaction [Asbestos, Serpentine results in decreased expression of BCL2L11 protein]

NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068

G

BCR activator of RhoGEF and GTPase

increases expression

Asbestos, Serpentine results in increased expression of BCR mRNA

NCBI chr20:13,469,325...13,596,942
Ensembl chr20:13,471,668...13,597,016

G

bradykinin receptor B1

decreases expression

Asbestos, Serpentine results in decreased expression of BDKRB1 mRNA

NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747

G

brain-enriched guanylate kinase-associated

increases expression

Asbestos, Serpentine results in increased expression of BEGAIN mRNA

NCBI chr 6:127,943,651...127,979,876
Ensembl chr 6:127,943,651...127,979,841

G

basic helix-loop-helix family, member e41

decreases expression

Asbestos, Serpentine results in decreased expression of BHLHE41 mRNA

NCBI chr 4:178,834,264...178,838,618
Ensembl chr 4:178,834,271...178,838,468

G

bone morphogenetic protein 6

decreases expression

Asbestos, Serpentine results in decreased expression of BMP6 mRNA

NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365

G

BOC cell adhesion associated, oncogene regulated

decreases methylation

Asbestos, Serpentine results in decreased methylation of BOC gene

NCBI chr11:56,122,697...56,198,060
Ensembl chr11:56,122,750...56,198,059

G

BPI fold containing family A, member 1

decreases expression
multiple interactions

Asbestos, Serpentine results in decreased expression of BPIFA1 mRNA
SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in decreased expression of BPIFA1 mRNA]

NCBI chr 3:142,627,810...142,633,553
Ensembl chr 3:142,627,810...142,633,552

G

bone marrow stromal cell antigen 2

increases expression

Asbestos, Serpentine results in increased expression of BST2 mRNA

NCBI chr16:18,216,605...18,220,979
Ensembl chr16:18,217,407...18,220,979

G

similar to human chromosome 1 open reading frame 226

decreases expression

Asbestos, Serpentine results in decreased expression of C1ORF226 mRNA

NCBI chr13:82,530,589...82,538,676
Ensembl chr13:82,530,577...82,820,949

G

complement C3

increases expression

Asbestos, Serpentine results in increased expression of C3 mRNA

NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429

G

complement C5

multiple interactions
increases cleavage

1,3-dimethylthiourea inhibits the reaction [Asbestos, Serpentine results in increased cleavage of C5 protein]; [Egtazic Acid co-treated with Asbestos, Serpentine] results in increased cleavage of C5 protein; [Ethylene Glycol co-treated with Asbestos, Serpentine] results in increased cleavage of C5 protein; Ascorbic Acid inhibits the reaction [Asbestos, Serpentine results in increased cleavage of C5 protein]; Deferoxamine inhibits the reaction [Asbestos, Serpentine results in increased cleavage of C5 protein]; Dithionite inhibits the reaction [Asbestos, Serpentine results in increased cleavage of C5 protein]

NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994

G

similar to human chromosome 19 open reading frame 38

decreases expression

Asbestos, Serpentine results in decreased expression of C19ORF38 mRNA

NCBI chr 8:20,061,494...20,095,705
Ensembl chr 8:20,078,639...20,095,696

G

calcium binding protein 39-like

increases expression

Asbestos, Serpentine results in increased expression of CAB39L mRNA

NCBI chr15:33,606,588...33,710,518
Ensembl chr15:33,606,694...33,743,545

G

calcium binding protein 7

increases expression

Asbestos, Serpentine results in increased expression of CABP7 mRNA

NCBI chr14:79,598,822...79,609,172
Ensembl chr14:79,598,827...79,609,240

G

calcium voltage-gated channel auxiliary subunit gamma 8

increases methylation

Asbestos, Serpentine results in increased methylation of CACNG8 5' UTR

NCBI chr 1:65,755,334...65,775,567
Ensembl chr 1:65,755,334...65,779,089

G

calmodulin 3

increases expression

Asbestos, Serpentine results in increased expression of CALM3 mRNA

NCBI chr 1:77,590,668...77,597,776
Ensembl chr 1:77,589,230...77,592,207

G

calcium/calmodulin-dependent protein kinase IV

decreases methylation

Asbestos, Serpentine results in decreased methylation of CAMK4 promoter

NCBI chr18:24,582,988...24,811,918
Ensembl chr18:24,585,269...24,802,487

G

cyclase associated actin cytoskeleton regulatory protein 2

decreases methylation

Asbestos, Serpentine results in decreased methylation of CAP2 3' UTR

NCBI chr17:18,054,234...18,203,453
Ensembl chr17:18,054,431...18,203,373

G

carbonic anhydrase 2

increases expression

Asbestos, Serpentine results in increased expression of CA2 mRNA

NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818

G

carbonic anhydrase 9

increases expression

Asbestos, Serpentine results in increased expression of CA9 mRNA

NCBI chr 5:57,763,234...57,769,838
Ensembl chr 5:57,763,206...57,769,838

G

calcium/calmodulin dependent serine protein kinase

decreases expression

Asbestos, Serpentine results in decreased expression of CASK mRNA

NCBI chr X:8,899,500...9,243,014
Ensembl chr X:8,899,833...9,238,694

G

cask-interacting protein 2

increases expression

Asbestos, Serpentine results in increased expression of CASKIN2 mRNA

NCBI chr10:101,027,196...101,041,429
Ensembl chr10:101,027,260...101,041,414

G

caspase 1

increases activity
increases expression
multiple interactions

Asbestos, Serpentine results in increased activity of CASP1 protein
Asbestos, Serpentine results in increased expression of CASP1 protein modified form
tyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone analog inhibits the reaction [Asbestos, Serpentine results in increased expression of CASP1 protein modified form]

NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383

G

caspase 3

increases cleavage
increases activity

Asbestos, Serpentine results in increased cleavage of CASP3 protein
Asbestos, Serpentine results in increased activity of CASP3 protein

PMID:18300051 PMID:22608188

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 9

increases cleavage
increases expression

Asbestos, Serpentine results in increased cleavage of CASP9 protein
Asbestos, Serpentine results in increased expression of CASP9 protein

PMID:18300051 PMID:24735948

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

coiled-coil domain containing 141

decreases methylation

Asbestos, Serpentine results in decreased methylation of CCDC141 5' UTR

NCBI chr 3:61,948,614...62,109,968
Ensembl chr 3:61,948,646...62,110,079

G

coiled-coil domain containing 149

decreases methylation

Asbestos, Serpentine results in decreased methylation of CCDC149 3' UTR; Asbestos, Serpentine results in decreased methylation of CCDC149 gene

NCBI chr14:58,509,583...58,605,017
Ensembl chr14:58,509,811...58,604,696

G

coiled-coil domain containing 66

increases expression

Asbestos, Serpentine results in increased expression of CCDC66 mRNA

NCBI chr16:2,662,125...2,694,031
Ensembl chr16:2,662,131...2,694,023

G

coiled coil domain containing 88A

increases expression

Asbestos, Serpentine results in increased expression of CCDC88A mRNA

NCBI chr14:103,104,091...103,256,112
Ensembl chr14:103,103,513...103,252,368

G

C-C motif chemokine ligand 11

increases secretion
decreases expression
multiple interactions

Asbestos, Serpentine results in increased secretion of CCL11 protein
Asbestos, Serpentine results in decreased expression of CCL11 protein
SPP1 gene mutant form promotes the reaction [Asbestos, Serpentine results in decreased expression of CCL11 protein]

PMID:21514415 PMID:23017228

NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926

G

C-C motif chemokine ligand 12

increases expression

Asbestos, Serpentine results in increased expression of CCL12 mRNA

NCBI chr10:67,070,230...67,071,780
Ensembl chr10:67,070,230...67,071,780

G

C-C motif chemokine ligand 2

increases expression
multiple interactions
increases secretion

Asbestos, Serpentine results in increased expression of CCL2 mRNA
Asbestos, Serpentine results in increased expression of CCL2 mRNA; Asbestos, Serpentine results in increased expression of CCL2 protein
PRKDC affects the reaction [Asbestos, Serpentine results in increased expression of CCL2 protein]
IL1B protein promotes the reaction [Asbestos, Serpentine results in increased expression of CCL2 mRNA]; IL1B protein promotes the reaction [Asbestos, Serpentine results in increased secretion of CCL2 protein]; TNF protein promotes the reaction [Asbestos, Serpentine results in increased expression of CCL2 mRNA]; TNF protein promotes the reaction [Asbestos, Serpentine results in increased secretion of CCL2 protein]

PMID:10923243 PMID:17200189 PMID:21514415 PMID:23917077 PMID:24160326

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 20

increases expression

Asbestos, Serpentine results in increased expression of CCL20 mRNA

NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629

G

C-C motif chemokine ligand 3

multiple interactions
increases expression

PRKDC affects the reaction [Asbestos, Serpentine results in increased expression of CCL3 protein]; SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in increased expression of CCL3 protein]

PMID:17200189 PMID:21514415

NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938

G

C-C motif chemokine ligand 4

decreases expression
increases expression
multiple interactions

Asbestos, Serpentine results in decreased expression of CCL4 mRNA
Asbestos, Serpentine results in increased expression of CCL4 protein
SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in increased expression of CCL4 protein]

PMID:17200189 PMID:21148743 PMID:21514415

NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231

G

C-C motif chemokine ligand 5

increases expression
multiple interactions

Asbestos, Serpentine results in increased expression of CCL5 protein
PRKDC affects the reaction [Asbestos, Serpentine results in increased expression of CCL5 protein]

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

C-C motif chemokine ligand 9

increases expression

Asbestos, Serpentine results in increased expression of CCL6 mRNA

NCBI chr10:68,366,486...68,371,408
Ensembl chr10:68,366,487...68,371,369

G

cellular communication network factor 2

increases expression
multiple interactions

Asbestos, Serpentine results in increased expression of CCN2
TGFB1 protein affects the reaction [Asbestos, Serpentine results in increased expression of CCN2]

NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734

G

cyclin B2

increases expression

Asbestos, Serpentine results in increased expression of CCNB2 mRNA

NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874

G

cyclin D1

multiple interactions

[MPO protein affects the susceptibility to Asbestos, Serpentine] which affects the expression of CCND1 protein

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

C-C motif chemokine receptor 2

increases expression

Asbestos, Serpentine results in increased expression of CCR2 mRNA

NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100

G

CD164 molecule

decreases methylation

Asbestos, Serpentine results in decreased methylation of CD164 gene

NCBI chr20:45,024,051...45,035,628
Ensembl chr20:45,023,973...45,035,634

G

CD209d molecule

decreases expression

Asbestos, Serpentine results in decreased expression of CD209 mRNA

NCBI chr12:1,891,109...1,897,559
Ensembl chr12:1,891,113...1,901,171

G

CD244 molecule

decreases expression

Asbestos, Serpentine results in decreased expression of CD244 protein

NCBI chr13:84,051,339...84,082,864
Ensembl chr13:84,052,493...84,074,492

G

CD36 molecule

decreases expression

Asbestos, Serpentine results in decreased expression of CD36 mRNA

NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903

G

CD44 molecule

increases expression

Asbestos, Serpentine results in increased expression of CD44 mRNA

PMID:21514415 PMID:29523930 PMID:33581214

NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620

G

CD59b molecule

increases mutagenesis

Asbestos, Serpentine results in increased mutagenesis of CD59 protein

NCBI chr 3:90,459,085...90,477,571
Ensembl chr 3:90,459,162...90,478,847

G

Cd68 molecule

increases expression

Asbestos, Serpentine results in increased expression of CD68 mRNA

NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697

G

CD79b molecule

increases expression

Asbestos, Serpentine results in increased expression of CD79B mRNA

NCBI chr10:91,239,354...91,242,500
Ensembl chr10:91,239,356...91,242,625

G

cell division cycle 20

increases expression

Asbestos, Serpentine results in increased expression of CDC20 mRNA

NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512

G

CUB domain containing protein 1

increases expression

Asbestos, Serpentine results in increased expression of CDCP1 mRNA

NCBI chr 8:122,828,685...122,865,345
Ensembl chr 8:122,828,685...122,865,388

G

cadherin 1

multiple interactions
decreases expression

1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one analog inhibits the reaction [Asbestos, Serpentine results in decreased expression of CDH1 protein]; SB 216763 inhibits the reaction [Asbestos, Serpentine results in decreased expression of CDH1 protein]; TGFB1 protein affects the reaction [Asbestos, Serpentine results in decreased expression of CDH1 protein]
Asbestos, Serpentine results in decreased expression of CDH1 mRNA; Asbestos, Serpentine results in decreased expression of CDH1 protein

PMID:24160326 PMID:26685284 PMID:30609805

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

cadherin 13

increases expression

Asbestos, Serpentine results in increased expression of CDH13 mRNA

NCBI chr19:46,349,562...47,387,462
Ensembl chr19:46,349,430...47,387,459

G

cadherin-related family member 1

decreases methylation

Asbestos, Serpentine results in decreased methylation of CDHR1 gene

NCBI chr16:12,843,436...12,863,321
Ensembl chr16:12,843,437...12,863,396

G

cyclin-dependent kinase 18

decreases methylation

Asbestos, Serpentine results in decreased methylation of CDK18 promoter

NCBI chr13:43,555,597...43,582,210
Ensembl chr13:43,556,748...43,588,525

G

cyclin-dependent kinase inhibitor 1B

decreases expression

Asbestos, Serpentine results in decreased expression of CDKN1B mRNA

NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982

G

cyclin-dependent kinase inhibitor 1C

decreases expression

Asbestos, Serpentine results in decreased expression of CDKN1C mRNA

NCBI chr 1:198,655,394...198,658,097
Ensembl chr 1:198,655,407...198,658,048

G

cyclin-dependent kinase inhibitor 2A

decreases expression

Asbestos, Serpentine results in decreased expression of CDKN2A mRNA; Asbestos, Serpentine results in decreased expression of CDKN2A protein

NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149

G

cysteine dioxygenase type 1

decreases expression

Asbestos, Serpentine results in decreased expression of CDO1 mRNA

NCBI chr18:39,432,473...39,447,253
Ensembl chr18:39,432,474...39,447,296

G

caudal type homeo box 2

decreases methylation

Asbestos, Serpentine results in decreased methylation of CDX2 promoter

NCBI chr12:7,726,798...7,733,142
Ensembl chr12:7,726,798...7,733,142

G

cell migration inducing hyaluronidase 1

increases expression

Asbestos, Serpentine results in increased expression of CEMIP mRNA

NCBI chr 1:137,906,921...138,062,430
Ensembl chr 1:137,908,920...138,062,415

G

centromere protein J

increases methylation

Asbestos, Serpentine results in increased methylation of CENPJ gene

NCBI chr15:30,627,206...30,690,384
Ensembl chr15:30,627,224...30,686,791

G

centrosomal protein 112

increases methylation

Asbestos, Serpentine results in increased methylation of CEP112 5' UTR

NCBI chr10:93,366,059...93,833,133
Ensembl chr10:93,366,136...93,833,131

G

carboxylesterase 3a

decreases expression

Asbestos, Serpentine results in decreased expression of CES3 mRNA

NCBI chr19:32,992,386...33,000,562

G

cyclic GMP-AMP synthase

decreases methylation

Asbestos, Serpentine results in decreased methylation of CGAS gene

NCBI chr 8:79,292,282...79,306,998
Ensembl chr 8:79,294,511...79,305,496

G

cholesterol 25-hydroxylase

increases expression

Asbestos, Serpentine results in increased expression of CH25H mRNA

NCBI chr 1:232,014,877...232,016,195
Ensembl chr 1:232,014,880...232,016,195

G

cell adhesion molecule L1-like

increases methylation

Asbestos, Serpentine results in increased methylation of CHL1 gene

NCBI chr 4:136,291,504...136,505,830
Ensembl chr 4:136,291,463...136,503,265

G

Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1

increases expression

Asbestos, Serpentine results in increased expression of CITED1 mRNA

NCBI chr X:67,350,376...67,355,072
Ensembl chr X:67,350,373...67,355,162

G

cytoskeleton associated protein 2

multiple interactions
increases expression

SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in increased expression of CKAP2 mRNA]

NCBI chr16:69,839,668...69,864,852
Ensembl chr16:69,839,630...69,864,913

G

creatine kinase B

decreases expression

Asbestos, Serpentine results in decreased expression of CKB mRNA

NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315

G

CDC28 protein kinase regulatory subunit 2

increases expression

Asbestos, Serpentine results in increased expression of CKS2 mRNA

NCBI chr17:13,570,611...13,575,770

G

chloride channel accessory 1

increases expression

Asbestos, Serpentine results in increased expression of CLCA1 mRNA; Asbestos, Serpentine results in increased expression of CLCA1 protein

NCBI chr 2:233,938,677...233,964,369
Ensembl chr 2:233,938,677...233,964,369

G

claudin 11

increases expression

Asbestos, Serpentine results in increased expression of CLDN11 mRNA

NCBI chr 2:112,207,745...112,221,050
Ensembl chr 2:112,207,745...112,221,050

G

claudin domain containing 2

decreases methylation

Asbestos, Serpentine results in decreased methylation of CLDND2 5' UTR

NCBI chr 1:93,848,533...93,851,693
Ensembl chr 1:93,848,533...93,851,217

G

chloride intracellular channel 3

decreases expression

Asbestos, Serpentine results in decreased expression of CLIC3 mRNA

NCBI chr 3:8,271,416...8,274,023
Ensembl chr 3:8,272,097...8,274,018

G

CAP-GLY domain containing linker protein 3

decreases expression

Asbestos, Serpentine results in decreased expression of CLIP3 mRNA

NCBI chr 1:85,547,170...85,563,187
Ensembl chr 1:85,547,206...85,563,184

G

clathrin heavy chain

decreases methylation

Asbestos, Serpentine results in decreased methylation of CLTC gene

NCBI chr10:71,517,661...71,574,591
Ensembl chr10:71,517,663...71,573,737

G

cms1 ribosomal small subunit homolog

affects methylation

Asbestos, Serpentine affects the methylation of CMSS1 gene

NCBI chr11:42,934,390...43,232,624
Ensembl chr11:42,934,440...43,232,624

G

cannabinoid receptor 1

increases methylation

Asbestos, Serpentine results in increased methylation of CNR1 5' UTR

NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099

G

collagen type XIX alpha 1 chain

increases methylation

Asbestos, Serpentine results in increased methylation of COL19A1 gene

NCBI chr 9:26,673,916...27,022,139
Ensembl chr 9:26,675,391...27,022,106

G

collagen type I alpha 1 chain

increases expression

Asbestos, Serpentine results in increased expression of COL1A1 mRNA

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

collagen type I alpha 2 chain

decreases expression
increases expression
multiple interactions

Asbestos, Serpentine results in decreased expression of COL1A2 mRNA
Asbestos, Serpentine results in increased expression of COL1A2 mRNA
SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in increased expression of COL1A2 mRNA]

PMID:16251409 PMID:21514415

NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867

G

collagen type III alpha 1 chain

increases expression
multiple interactions

Asbestos, Serpentine results in increased expression of COL3A1 mRNA
SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in increased expression of COL3A1 mRNA]

NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547

G

collagen type IV alpha 1 chain

increases expression

Asbestos, Serpentine results in increased expression of COL4A1 mRNA

NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412

G

collagen type V alpha 1 chain

increases expression

Asbestos, Serpentine results in increased expression of COL5A1 mRNA

NCBI chr 3:11,208,429...11,356,715
Ensembl chr 3:11,208,512...11,354,588

G

ceruloplasmin

increases expression

Asbestos, Serpentine results in increased expression of CP mRNA

NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075

G

complexin 1

increases methylation

Asbestos, Serpentine results in increased methylation of CPLX1 5' UTR

NCBI chr14:1,184,677...1,216,392

G

CASP2 and RIPK1 domain containing adaptor with death domain

decreases expression

Asbestos, Serpentine results in decreased expression of CRADD mRNA

NCBI chr 7:29,940,240...29,952,907
Ensembl chr 7:29,798,586...29,952,907

G

cysteine-rich secretory protein 1

increases methylation

Asbestos, Serpentine results in increased methylation of CRISP1 5' UTR

NCBI chr 9:20,741,775...20,768,796
Ensembl chr 9:20,741,777...20,768,796

G

cysteine-rich secretory protein LCCL domain containing 2

increases expression

Asbestos, Serpentine results in increased expression of CRISPLD2 mRNA

NCBI chr19:48,053,153...48,111,485
Ensembl chr19:48,053,287...48,110,465

G

crystallin, lambda 1

increases methylation

Asbestos, Serpentine results in increased methylation of CRYL1 gene

NCBI chr15:31,427,011...31,545,997
Ensembl chr15:31,427,054...31,545,997

G

colony stimulating factor 2

increases expression
increases secretion
multiple interactions

Asbestos, Serpentine results in increased expression of CSF2 mRNA
[Asbestos, Serpentine results in increased secretion of IL1B protein] which results in increased secretion of CSF2 protein
Asbestos, Serpentine results in increased expression of CSF2 protein
PRKDC affects the reaction [Asbestos, Serpentine results in increased expression of CSF2 protein]

PMID:17200189 PMID:23017228 PMID:24160326

NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199

G

colony stimulating factor 3

increases expression
increases secretion

Asbestos, Serpentine results in increased expression of CSF3 mRNA
Asbestos, Serpentine results in increased secretion of CSF3 protein
Asbestos, Serpentine results in increased expression of CSF3 protein

PMID:17200189 PMID:23017228 PMID:24160326

NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603

G

cystatin A

increases expression

Asbestos, Serpentine results in increased expression of CSTA mRNA

NCBI chr11:64,620,483...64,631,488
Ensembl chr11:64,620,483...64,631,488

G

catenin beta 1

decreases expression
multiple interactions

Asbestos, Serpentine results in decreased expression of CTNNB1 mRNA; Asbestos, Serpentine results in decreased expression of CTNNB1 protein
Asbestos, Serpentine results in increased phosphorylation of and affects the localization of CTNNB1 protein; TGFB1 protein affects the reaction [Asbestos, Serpentine results in decreased expression of CTNNB1 protein]; TNF protein promotes the reaction [Asbestos, Serpentine affects the localization of CTNNB1 protein]

PMID:24160326 PMID:26685284 PMID:30609805

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

cathepsin K

increases expression

Asbestos, Serpentine results in increased expression of CTSK mRNA; Asbestos, Serpentine results in increased expression of CTSK protein

NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550

G

cathepsin S

increases expression

Asbestos, Serpentine results in increased expression of CTSS mRNA

PMID:16251409 PMID:24160326

NCBI chr 2:183,086,437...183,114,483
Ensembl chr 2:183,086,437...183,114,483

G

cathepsin Z

increases expression

Asbestos, Serpentine results in increased expression of CTSZ mRNA

NCBI chr 3:163,224,875...163,235,645
Ensembl chr 3:163,224,875...163,235,645

G

C-X-C motif chemokine ligand 1

multiple interactions
increases expression

[Asbestos, Serpentine co-treated with 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide] results in increased expression of CXCL1 mRNA
Asbestos, Serpentine results in increased expression of CXCL1 mRNA

PMID:18197826 PMID:24160326

NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215

G

C-X-C motif chemokine ligand 10

decreases expression
increases expression
multiple interactions

Asbestos, Serpentine results in decreased expression of CXCL10 protein
Asbestos, Serpentine results in increased expression of CXCL10 mRNA
SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in increased expression of CXCL10 mRNA]

PMID:21148743 PMID:21514415 PMID:24160326

NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975

G

C-X-C motif chemokine ligand 12

increases expression

Asbestos, Serpentine results in increased expression of CXCL12 mRNA

PMID:19105532 PMID:24160326

NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168

G

C-X-C motif chemokine ligand 13

increases expression

Asbestos, Serpentine results in increased expression of CXCL13 mRNA

NCBI chr14:13,608,894...13,613,965
Ensembl chr14:13,608,902...13,613,933

G

C-X-C motif chemokine ligand 2

increases expression

Asbestos, Serpentine results in increased expression of CXCL2 mRNA

NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075

G

C-X-C motif chemokine ligand 3

increases expression
multiple interactions

Asbestos, Serpentine results in increased expression of CXCL1 protein
NLRP3 protein affects the reaction [Asbestos, Serpentine results in increased expression of CXCL1 protein]; PRKDC affects the reaction [Asbestos, Serpentine results in increased expression of CXCL1 protein]
[Asbestos, Serpentine co-treated with 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide] results in increased expression of CXCL1 mRNA
Asbestos, Serpentine results in increased expression of CXCL1 mRNA

PMID:17200189 PMID:18197826 PMID:18403674 PMID:24160326

NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511

G

C-X-C motif chemokine ligand 6

increases expression

Asbestos, Serpentine results in increased expression of CXCL6 mRNA

NCBI chr14:17,310,790...17,312,250
Ensembl chr14:17,310,426...17,313,093

G

C-X-C motif chemokine receptor 3

decreases expression

Asbestos, Serpentine results in decreased expression of CXCR3 mRNA; Asbestos, Serpentine results in decreased expression of CXCR3 protein

PMID:21148743 PMID:21357438

NCBI chr X:66,844,318...66,846,969
Ensembl chr X:66,844,318...66,846,969

G

C-X-C motif chemokine receptor 4

increases expression

Asbestos, Serpentine results in increased expression of CXCR4 mRNA

NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883

G

CXXC finger protein 5

decreases expression

Asbestos, Serpentine results in decreased expression of CXXC5 mRNA

NCBI chr18:27,427,591...27,458,579
Ensembl chr18:27,427,230...27,458,673

G

cytochrome P450, family 11, subfamily a, polypeptide 1

decreases methylation

Asbestos, Serpentine results in decreased methylation of CYP11A1 promoter

NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338

G

cytochrome P450, family 19, subfamily a, polypeptide 1

decreases expression

Asbestos, Serpentine results in decreased expression of CYP19A1 mRNA

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

cytochrome P450, family 1, subfamily a, polypeptide 1

affects activity

Asbestos, Serpentine affects the activity of CYP1A1 protein

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 26, subfamily C, polypeptide 1

decreases methylation

Asbestos, Serpentine results in decreased methylation of CYP26C1 promoter

NCBI chr 1:235,458,961...235,468,433
Ensembl chr 1:235,459,356...235,466,842

G

cytochrome P450, family 27, subfamily a, polypeptide 1

decreases methylation

Asbestos, Serpentine results in decreased methylation of CYP27A1 promoter

NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551

G

cytochrome P450, family 27, subfamily b, polypeptide 1

decreases methylation

Asbestos, Serpentine results in decreased methylation of CYP27B1 promoter

NCBI chr 7:62,869,340...62,876,242
Ensembl chr 7:62,871,297...62,876,241

G

cytochrome P450, family 2, subfamily a, polypeptide 3

decreases expression
multiple interactions

Asbestos, Serpentine results in decreased expression of CYP2A4 mRNA
SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in decreased expression of CYP2A4 mRNA]

NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979

G

cytochrome P450, family 2, subfamily f, polypeptide 4

increases methylation

Asbestos, Serpentine results in increased methylation of CYP2F1 gene

NCBI chr 1:82,416,107...82,429,897
Ensembl chr 1:82,416,130...82,429,896

G

cytochrome P450, family 2, subfamily w, polypeptide 1

decreases methylation

Asbestos, Serpentine results in decreased methylation of CYP2W1 promoter

NCBI chr12:15,291,552...15,296,421
Ensembl chr12:15,291,704...15,296,421

G

cytohesin 1 interacting protein

increases expression

Asbestos, Serpentine results in increased expression of CYTIP mRNA

NCBI chr 3:42,698,058...42,774,955
Ensembl chr 3:42,698,768...42,725,993

G

cytokine like 1

decreases expression

Asbestos, Serpentine results in decreased expression of CYTL1 mRNA

NCBI chr14:73,053,876...73,058,886
Ensembl chr14:73,053,877...73,058,886

G

deleted in azoospermia-like

decreases methylation

Asbestos, Serpentine results in decreased methylation of DAZL promoter

NCBI chr 9:10,695,593...10,712,330
Ensembl chr 9:10,695,592...10,712,323

G

dephospho-CoA kinase domain containing

increases methylation

Asbestos, Serpentine results in increased methylation of DCAKD 5' UTR

NCBI chr10:87,957,738...87,989,002
Ensembl chr10:87,957,740...87,980,054

G

dachsous cadherin-related 2

increases methylation

Asbestos, Serpentine results in increased methylation of DCHS2 gene

NCBI chr 2:168,478,298...168,685,802
Ensembl chr 2:168,478,826...168,682,732

G

doublecortin-like kinase 1

decreases methylation

Asbestos, Serpentine results in decreased methylation of DCLK1 promoter

NCBI chr 2:139,417,234...139,710,956
Ensembl chr 2:139,417,163...139,710,956

G

decorin

increases expression

Asbestos, Serpentine results in increased expression of DCN mRNA

NCBI chr 7:32,281,252...32,321,291
Ensembl chr 7:32,281,252...32,321,270

G

DNA-damage inducible transcript 3

increases expression

Asbestos, Serpentine results in increased expression of DDIT3 mRNA

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

DENN domain containing 1B

decreases expression

Asbestos, Serpentine results in decreased expression of DENND1B mRNA

NCBI chr13:50,545,324...50,772,922
Ensembl chr13:50,545,836...50,770,601

G

DENN domain containing 5A

affects expression

Asbestos, Serpentine affects the expression of DENND5A mRNA

NCBI chr 1:163,928,183...163,994,207
Ensembl chr 1:163,928,183...163,994,316

G

dehydrogenase/reductase 9

increases expression

Asbestos, Serpentine results in increased expression of DHRS9 mRNA

NCBI chr 3:54,147,834...54,170,052
Ensembl chr 3:54,147,803...54,220,241

G

iodothyronine deiodinase 2

increases expression

Asbestos, Serpentine results in increased expression of DIO2 mRNA

NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809

G

dickkopf WNT signaling pathway inhibitor 1

increases expression

Asbestos, Serpentine results in increased expression of DKK1 mRNA

NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202

G

dystrophin

increases expression

Asbestos, Serpentine results in increased expression of DMD mRNA

NCBI chr X:47,272,324...49,504,219
Ensembl chr X:47,272,331...49,504,207

G

DM1 protein kinase

decreases methylation

Asbestos, Serpentine results in decreased methylation of DMPK promoter

NCBI chr 1:78,730,255...78,740,585
Ensembl chr 1:78,730,275...78,740,593

G

DnaJ heat shock protein family (Hsp40) member C3

increases expression

Asbestos, Serpentine results in increased expression of DNAJC3 mRNA

NCBI chr15:96,025,605...96,068,585
Ensembl chr15:96,025,624...96,065,181

G

delta/notch-like EGF repeat containing

increases expression

Asbestos, Serpentine results in increased expression of DNER mRNA

NCBI chr 9:85,586,985...85,902,461
Ensembl chr 9:85,586,987...85,902,637

G

dipeptidase 1

decreases expression

Asbestos, Serpentine results in decreased expression of DPEP1 mRNA

NCBI chr19:51,209,831...51,237,004
Ensembl chr19:51,219,660...51,235,257

G

Dr1 associated protein 1

increases expression

Asbestos, Serpentine results in increased expression of DRAP1 mRNA

NCBI chr 1:202,731,775...202,734,468
Ensembl chr 1:202,731,788...202,734,425

G

DS cell adhesion molecule

decreases methylation

Asbestos, Serpentine results in decreased methylation of DSCAM 3' UTR

NCBI chr11:35,921,924...36,507,100
Ensembl chr11:35,926,896...36,507,415

G

dystrobrevin binding protein 1

increases methylation

Asbestos, Serpentine results in increased methylation of DTNBP1 5' UTR

NCBI chr17:19,685,218...19,776,668
Ensembl chr17:19,685,215...19,776,661

G

dual specificity phosphatase 10

decreases expression

Asbestos, Serpentine results in decreased expression of DUSP10 mRNA

NCBI chr13:95,613,716...95,651,716
Ensembl chr13:95,614,292...95,651,716

G

endothelin converting enzyme 1

decreases methylation

Asbestos, Serpentine results in decreased methylation of ECE1 gene

NCBI chr 5:150,077,679...150,179,375
Ensembl chr 5:150,077,644...150,179,371

G

EGF like repeats and discoidin domains 3

decreases methylation

Asbestos, Serpentine results in decreased methylation of EDIL3 gene

NCBI chr 2:19,890,396...20,405,028
Ensembl chr 2:19,890,373...20,405,008

G

endothelin receptor type B

increases methylation

Asbestos, Serpentine results in increased methylation of EDNRB 5' UTR

NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115

G

EF-hand domain family, member D1

decreases expression
decreases methylation

Asbestos, Serpentine results in decreased expression of EFHD1 mRNA
Asbestos, Serpentine results in decreased methylation of EFHD1 gene

NCBI chr 9:87,938,259...87,984,917
Ensembl chr 9:87,938,284...87,984,917

G

elongation factor like GTPase 1

increases expression

Asbestos, Serpentine results in increased expression of EFL1 mRNA

NCBI chr 1:136,638,527...136,763,518
Ensembl chr 1:136,638,527...136,763,518

G

ephrin A3

decreases methylation

Asbestos, Serpentine results in decreased methylation of EFNA3 gene

NCBI chr 2:174,729,192...174,738,111
Ensembl chr 2:174,729,764...174,738,736

G

epidermal growth factor receptor

decreases phosphorylation
increases activity
multiple interactions

Asbestos, Serpentine results in decreased phosphorylation of EGFR protein
Asbestos, Serpentine results in increased activity of EGFR protein
N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Asbestos, Serpentine results in increased activity of EGFR protein]

PMID:15626777 PMID:16571779

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

early growth response 1

increases expression
multiple interactions

Asbestos, Serpentine results in increased expression of EGR1 mRNA
clinoptilolite inhibits the reaction [Asbestos, Serpentine results in increased expression of EGR1 mRNA]

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

EH-domain containing 1

affects expression

Asbestos, Serpentine affects the expression of EHD1 mRNA

NCBI chr 1:203,579,850...203,602,226
Ensembl chr 1:203,579,869...203,602,212

G

ets homologous factor

increases expression

Asbestos, Serpentine results in increased expression of EHF mRNA

NCBI chr 3:89,639,845...89,680,061
Ensembl chr 3:89,641,833...89,679,997

G

eukaryotic translation initiation factor 3, subunit G

decreases methylation

Asbestos, Serpentine results in decreased methylation of EIF3G promoter

NCBI chr 8:19,429,728...19,433,760
Ensembl chr 8:19,429,643...19,433,808

G

eukaryotic translation initiation factor 3, subunit H

increases expression

Asbestos, Serpentine results in increased expression of EIF3H mRNA

NCBI chr 7:83,091,037...83,174,451
Ensembl chr 7:83,091,039...83,174,451

G

eukaryotic translation initiation factor 4 gamma, 3

decreases expression

Asbestos, Serpentine results in decreased expression of EIF4G3 mRNA

NCBI chr 5:150,197,410...150,418,862
Ensembl chr 5:150,195,226...150,418,363

G

ETS transcription factor ELK1

increases phosphorylation

[Asbestos, Serpentine results in increased phosphorylation of MAPK1 protein] which results in increased phosphorylation of ELK1 protein; [Asbestos, Serpentine results in increased phosphorylation of MAPK3 protein] which results in increased phosphorylation of ELK1 protein

NCBI chr X:1,138,826...1,155,713
Ensembl chr X:1,139,756...1,155,713

G

elastin

increases expression
multiple interactions

Asbestos, Serpentine results in increased expression of ELN mRNA
SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in increased expression of ELN mRNA]

NCBI chr12:21,968,544...22,011,929
Ensembl chr12:21,968,544...22,011,928

G

elastin microfibril interfacer 1

increases expression

Asbestos, Serpentine results in increased expression of EMILIN1 mRNA

NCBI chr 6:25,455,974...25,463,713
Ensembl chr 6:25,445,298...25,463,698

G

endoglin

decreases expression

Asbestos, Serpentine results in decreased expression of ENG mRNA

NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230

G

ectonucleotide pyrophosphatase/phosphodiesterase 2

increases methylation

Asbestos, Serpentine results in increased methylation of ENPP2 gene

NCBI chr 7:86,202,345...86,325,050
Ensembl chr 7:86,202,350...86,324,827

G

epithelial stromal interaction 1

decreases expression

Asbestos, Serpentine results in decreased expression of EPSTI1 mRNA

NCBI chr15:53,283,964...53,382,192
Ensembl chr15:53,284,216...53,382,191

G

ELKS/RAB6-interacting/CAST family member 2

decreases methylation

Asbestos, Serpentine results in decreased methylation of ERC2 3' UTR

NCBI chr16:2,812,712...3,673,624
Ensembl chr16:2,848,620...3,670,776

G

epiregulin

increases expression

Asbestos, Serpentine results in increased expression of EREG mRNA

PMID:23917077 PMID:24160326

NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062

G

endoplasmic reticulum to nucleus signaling 2

decreases methylation

Asbestos, Serpentine results in decreased methylation of ERN2 promoter

NCBI chr 1:176,726,454...176,743,289
Ensembl chr 1:176,726,454...176,743,289

G

endoplasmic reticulum oxidoreductase 1 alpha

increases expression

Asbestos, Serpentine results in increased expression of ERO1A mRNA

NCBI chr15:18,495,037...18,530,440
Ensembl chr15:18,492,945...18,530,478

G

estrogen receptor 2

decreases methylation

Asbestos, Serpentine results in decreased methylation of ESR2 5' UTR

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

estrogen-related receptor gamma

decreases methylation

Asbestos, Serpentine results in decreased methylation of ESRRG 5' UTR

NCBI chr13:99,167,656...99,788,016
Ensembl chr13:99,564,669...99,783,397

G

coagulation factor III, tissue factor

increases activity
increases expression

Asbestos, Serpentine results in increased activity of F3 protein
Asbestos, Serpentine results in increased expression of F3 mRNA

PMID:15636197 PMID:29523930

NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668

G

family with sequence similarity 124 member B

increases expression

Asbestos, Serpentine results in increased expression of FAM124B mRNA

NCBI chr 9:81,513,018...81,533,621
Ensembl chr 9:81,515,399...81,533,341

G

family with sequence similarity 193, member B

increases expression

Asbestos, Serpentine results in increased expression of FAM193B mRNA

NCBI chr17:9,066,818...9,099,511
Ensembl chr17:9,066,707...9,099,508

G

FAM20C, golgi associated secretory pathway kinase

increases expression

Asbestos, Serpentine results in increased expression of FAM20C mRNA

NCBI chr12:15,826,864...15,885,423
Ensembl chr12:15,826,871...15,884,543

G

FAM3 metabolism regulating signaling molecule B

increases expression

Asbestos, Serpentine results in increased expression of FAM3B mRNA

NCBI chr11:36,831,532...36,863,902
Ensembl chr11:36,831,532...36,869,713

G

FERM, ARH/RhoGEF and pleckstrin domain protein 1

increases methylation
decreases methylation

Asbestos, Serpentine results in increased methylation of FARP1 3' UTR
Asbestos, Serpentine results in decreased methylation of FARP1 promoter

PMID:29523930 PMID:29626692

NCBI chr15:98,124,304...98,363,299
Ensembl chr15:98,182,329...98,363,299

G

fibrillarin-like 1

decreases expression

Asbestos, Serpentine results in decreased expression of FBLL1 mRNA

NCBI chr10:20,258,656...20,260,299
Ensembl chr10:20,258,656...20,260,299

G

F-box protein 2

increases expression

Asbestos, Serpentine results in increased expression of FBXO2 mRNA

NCBI chr 5:158,592,926...158,598,355
Ensembl chr 5:158,592,925...158,598,355

G

Fc epsilon receptor Ig

decreases expression

Asbestos, Serpentine results in decreased expression of FCER1G mRNA

NCBI chr13:83,649,447...83,654,248
Ensembl chr13:83,649,449...83,671,443

G

FCH and mu domain containing endocytic adaptor 1

decreases methylation

Asbestos, Serpentine results in decreased methylation of FCHO1 5' UTR

NCBI chr16:18,413,452...18,430,795
Ensembl chr16:18,413,363...18,435,104

G

fibroblast growth factor 2

increases secretion
increases expression

[Asbestos, Serpentine results in increased secretion of IL1B protein] which results in increased secretion of FGF2 protein
Asbestos, Serpentine results in increased expression of FGF2 mRNA

PMID:9400719 PMID:23017228

NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221

G

fibrinogen-like 1

increases expression

Asbestos, Serpentine results in increased expression of FGL1 mRNA

NCBI chr16:51,120,652...51,150,907
Ensembl chr16:51,120,694...51,151,093

G

filamin A interacting protein 1-like

affects methylation

Asbestos, Serpentine affects the methylation of FILIP1L 5' UTR

NCBI chr11:42,937,353...43,177,085
Ensembl chr11:42,940,467...43,177,415

G

Fms related receptor tyrosine kinase 1

decreases expression

Asbestos, Serpentine results in decreased expression of FLT1 mRNA

NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626

G

flavin containing dimethylaniline monoxygenase 3

decreases expression
multiple interactions

Asbestos, Serpentine results in decreased expression of FMO3 mRNA
SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in decreased expression of FMO3 mRNA]

PMID:16251409 PMID:21514415

NCBI chr13:75,309,367...75,334,915
Ensembl chr13:75,309,374...75,328,028

G

fibronectin 1

increases expression
multiple interactions
increases metabolic processing

Asbestos, Serpentine results in increased expression of FN1 mRNA; Asbestos, Serpentine results in increased expression of FN1 protein
TGFB1 protein affects the reaction [Asbestos, Serpentine results in increased expression of FN1 protein]
Asbestos, Serpentine results in increased metabolism of FN1 protein

PMID:18569384 PMID:21514415 PMID:26685284 PMID:30609805 PMID:33581214

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

fibronectin type III domain containing 9

decreases expression

Asbestos, Serpentine results in decreased expression of FNDC9 mRNA

NCBI chr10:30,664,435...30,668,213
Ensembl chr10:30,667,091...30,667,771

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

Asbestos, Serpentine results in increased expression of FOS mRNA; Asbestos, Serpentine results in increased expression of FOS protein

PMID:8386370 PMID:32755622

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

FOS like 1, AP-1 transcription factor subunit

increases expression

Asbestos, Serpentine results in increased expression of FOSL1 mRNA

PMID:23917077 PMID:29523930

NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930

G

forkhead box D2

decreases methylation

Asbestos, Serpentine results in decreased methylation of FOXD2 promoter

NCBI chr 5:128,427,986...128,430,709
Ensembl chr 5:128,429,020...128,430,504

G

forkhead box F2

increases expression

Asbestos, Serpentine results in increased expression of FOXF2 mRNA

NCBI chr17:32,835,730...32,842,547
Ensembl chr17:32,836,777...32,842,176

G

forkhead box I2

decreases methylation

Asbestos, Serpentine results in decreased methylation of FOXI2 promoter

NCBI chr 1:190,222,857...190,226,657
Ensembl chr 1:190,222,703...190,226,433

G

forkhead box O1

decreases expression

Asbestos, Serpentine results in decreased expression of FOXO1 mRNA

NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790

G

follistatin

decreases expression

Asbestos, Serpentine results in decreased expression of FST mRNA

NCBI chr 2:46,123,260...46,130,584
Ensembl chr 2:46,123,439...46,130,571

G

G0/G1switch 2

affects expression

Asbestos, Serpentine affects the expression of G0S2 mRNA

NCBI chr13:104,806,351...104,807,263
Ensembl chr13:104,806,156...104,807,451

G

glucose-6-phosphate dehydrogenase

decreases activity
multiple interactions

Asbestos, Serpentine results in decreased activity of G6PD protein
[Kerosene co-treated with Asbestos, Serpentine] results in increased activity of G6PD protein; [Soot co-treated with Asbestos, Serpentine] results in increased activity of G6PD protein

PMID:9177657 PMID:16039947 PMID:18370412

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

GRB2-associated binding protein 2

increases expression

Asbestos, Serpentine results in increased expression of GAB2 mRNA

NCBI chr 1:151,429,844...151,625,708
Ensembl chr 1:151,429,695...151,625,031

G

gamma-aminobutyric acid type A receptor subunit epsilon

decreases expression

Asbestos, Serpentine results in decreased expression of GABRE mRNA

NCBI chr X:150,060,035...150,078,773
Ensembl chr X:150,060,040...150,078,693

G

growth arrest and DNA-damage-inducible, alpha

increases expression

Asbestos, Serpentine results in increased expression of GADD45A mRNA

NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115

G

cyclin G associated kinase

decreases methylation

Asbestos, Serpentine results in decreased methylation of GAK promoter

NCBI chr14:1,089,853...1,164,098
Ensembl chr14:1,089,866...1,216,398

G

polypeptide N-acetylgalactosaminyltransferase 18

increases methylation

Asbestos, Serpentine results in increased methylation of GALNT18 gene

NCBI chr 1:165,593,180...165,904,268
Ensembl chr 1:165,593,187...165,904,268

G

glyceraldehyde-3-phosphate dehydrogenase

increases expression

Asbestos, Serpentine results in increased expression of GAPDH mRNA

NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235

G

growth arrest specific 5

affects methylation

Asbestos, Serpentine affects the methylation of GAS5 gene

NCBI chr13:73,303,611...73,306,932

G

GRIP and coiled-coil domain containing 2

increases expression

Asbestos, Serpentine results in increased expression of GCC2 mRNA

NCBI chr20:26,247,394...26,293,613
Ensembl chr20:26,247,404...26,293,613

G

growth differentiation factor 15

increases expression

Asbestos, Serpentine results in increased expression of GDF15 mRNA

NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055

G

glutamine-fructose-6-phosphate transaminase 2

increases expression

Asbestos, Serpentine results in increased expression of GFPT2 mRNA

NCBI chr10:34,115,005...34,161,329
Ensembl chr10:34,115,052...34,161,329

G

growth hormone receptor

increases expression

Asbestos, Serpentine results in increased expression of GHR mRNA

NCBI chr 2:52,541,452...52,804,960
Ensembl chr 2:52,542,594...52,804,735

G

glycerol-3-phosphate acyltransferase, mitochondrial

decreases expression

Asbestos, Serpentine results in decreased expression of GPAM mRNA

NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639

G

glypican 5

increases methylation

Asbestos, Serpentine results in increased methylation of GPC5 3' UTR

NCBI chr15:92,207,275...93,644,054
Ensembl chr15:92,239,176...93,643,282

G

G protein-coupled receptor 85

increases methylation

Asbestos, Serpentine results in increased methylation of GPR85 5' UTR

NCBI chr 4:42,100,138...42,109,584
Ensembl chr 4:42,102,941...42,109,566

G

GRAM domain containing 1C

increases expression

Asbestos, Serpentine results in increased expression of GRAMD1C mRNA

NCBI chr11:56,633,229...56,718,570
Ensembl chr11:56,633,227...56,718,570

G

gremlin 1, DAN family BMP antagonist

increases expression

Asbestos, Serpentine results in increased expression of GREM1 mRNA

NCBI chr 3:100,512,317...100,524,001
Ensembl chr 3:100,512,313...100,524,082

G

glutamate ionotropic receptor NMDA type subunit 2D

decreases methylation

Asbestos, Serpentine results in decreased methylation of GRIN2D gene

NCBI chr 1:96,306,871...96,346,994
Ensembl chr 1:96,308,365...96,344,793

G

glycogen synthase kinase 3 beta

increases phosphorylation
multiple interactions

Asbestos, Serpentine results in increased phosphorylation of GSK3B protein
1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one analog inhibits the reaction [Asbestos, Serpentine results in increased phosphorylation of GSK3B protein]

PMID:26685284 PMID:30609805

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

GTF2I repeat domain containing 1

decreases methylation

Asbestos, Serpentine results in decreased methylation of GTF2IRD1 promoter

NCBI chr12:22,254,113...22,361,052
Ensembl chr12:22,254,221...22,361,040

G

granzyme A

decreases expression

Asbestos, Serpentine results in decreased expression of GZMA protein

NCBI chr 2:44,740,569...44,752,502
Ensembl chr 2:44,740,569...44,752,493

G

H19 imprinted maternally expressed transcript

decreases expression

Asbestos, Serpentine results in decreased expression of H19 mRNA

NCBI chr 1:197,730,698...197,733,374
Ensembl chr 1:197,730,698...197,733,134

G

hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)

multiple interactions

Asbestos, Serpentine results in increased metabolism of and results in decreased activity of H6PD protein

NCBI chr 5:160,434,499...160,470,203
Ensembl chr 5:160,438,697...160,470,171

G

hepcidin antimicrobial peptide

decreases expression
multiple interactions

Asbestos, Serpentine results in decreased expression of HAMP mRNA
SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in decreased expression of HAMP mRNA]

NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891

G

hyaluronan synthase 2

increases expression

Asbestos, Serpentine results in increased expression of HAS2 mRNA

NCBI chr 7:88,113,326...88,139,337
Ensembl chr 7:88,113,326...88,128,933

G

HDGF like 3

increases expression

Asbestos, Serpentine results in increased expression of HDGFL3 mRNA

PMID:21148743 PMID:33581214

NCBI chr 1:135,822,600...135,876,719
Ensembl chr 1:135,827,549...135,876,719

G

HECT and RLD domain containing E3 ubiquitin protein ligase 4

increases expression

Asbestos, Serpentine results in increased expression of HERC4 mRNA

NCBI chr20:25,329,972...25,404,657
Ensembl chr20:25,330,280...25,404,657

G

HECT and RLD domain containing E3 ubiquitin protein ligase family member 6

decreases expression

Asbestos, Serpentine results in decreased expression of HERC6 mRNA

NCBI chr 4:87,524,470...87,566,895
Ensembl chr 4:87,524,493...87,581,744

G

histidine triad nucleotide binding protein 3

decreases expression

Asbestos, Serpentine results in decreased expression of HINT3 mRNA

NCBI chr 1:27,035,936...27,045,799
Ensembl chr 1:27,035,905...27,047,721

G

homeodomain interacting protein kinase 2

decreases methylation

Asbestos, Serpentine results in decreased methylation of HIPK2 3' UTR

NCBI chr 4:67,439,327...67,619,223
Ensembl chr 4:67,440,501...67,619,223

G

HIVEP zinc finger 2

affects expression

Asbestos, Serpentine affects the expression of HIVEP2 mRNA

NCBI chr 1:8,358,205...8,555,993
Ensembl chr 1:8,359,289...8,555,993

G

hexokinase 2

increases expression

Asbestos, Serpentine results in increased expression of HK2 mRNA

NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530

G

HLF transcription factor, PAR bZIP family member

decreases expression
multiple interactions

Asbestos, Serpentine results in decreased expression of HLF mRNA
SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in decreased expression of HLF mRNA]

NCBI chr10:75,154,244...75,211,884
Ensembl chr10:75,154,507...75,211,935

G

high mobility group AT-hook 2

increases expression

Asbestos, Serpentine results in increased expression of HMGA2 mRNA

NCBI chr 7:55,877,145...55,998,813
Ensembl chr 7:55,880,112...55,994,784

G

high mobility group box 1

increases secretion

Asbestos, Serpentine results in increased secretion of HMGB1 protein

NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565

G

heme oxygenase 1

increases expression

Asbestos, Serpentine results in increased expression of HMOX1 mRNA

PMID:8118652 PMID:16251409

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

heterogeneous nuclear ribonucleoprotein H1

decreases methylation

Asbestos, Serpentine results in decreased methylation of HNRNPH1 5' UTR

NCBI chr10:34,692,868...34,702,849
Ensembl chr10:34,693,555...34,702,846

G

heterogeneous nuclear ribonucleoprotein U

decreases expression

Asbestos, Serpentine results in decreased expression of HNRNPU mRNA

NCBI chr13:90,069,058...90,086,905
Ensembl chr13:90,074,181...90,086,588

G

homeobox A3

decreases methylation

Asbestos, Serpentine results in decreased methylation of HOXA3 promoter

NCBI chr 4:81,269,243...81,313,218
Ensembl chr 4:81,269,243...81,313,218

G

homeo box B3

decreases methylation

Asbestos, Serpentine results in decreased methylation of HOXB3 promoter

NCBI chr10:81,258,739...81,314,134
Ensembl chr10:81,299,357...81,313,107

G

homeo box B7

decreases methylation

Asbestos, Serpentine results in decreased methylation of HOXB7 promoter

NCBI chr10:81,252,616...81,256,034
Ensembl chr10:81,252,553...81,256,034

G

homeobox C11

decreases methylation

Asbestos, Serpentine results in decreased methylation of HOXC11 promoter

NCBI chr 7:134,091,224...134,094,738
Ensembl chr 7:134,091,552...134,094,738

G

homeobox D11

decreases methylation

Asbestos, Serpentine results in decreased methylation of HOXD11 promoter

NCBI chr 3:59,584,840...59,587,257
Ensembl chr 3:59,585,039...59,586,783

G

homeo box D12

decreases methylation

Asbestos, Serpentine results in decreased methylation of HOXD12 promoter

NCBI chr 3:59,577,677...59,578,798
Ensembl chr 3:59,577,677...59,578,798

G

haptoglobin

decreases expression

Asbestos, Serpentine results in decreased expression of HP mRNA

NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523

G

HRas proto-oncogene, GTPase

increases expression
multiple interactions

Asbestos, Serpentine results in increased expression of HRAS protein
tobacco tar promotes the reaction [Asbestos, Serpentine results in increased expression of HRAS protein]

NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615

G

heparan sulfate-glucosamine 3-sulfotransferase 1

increases methylation

Asbestos, Serpentine results in increased methylation of HS3ST1 5' UTR

NCBI chr14:71,185,826...71,223,263
Ensembl chr14:71,185,682...71,223,248

G

hydroxysteroid 11-beta dehydrogenase 1

increases expression
decreases expression

Asbestos, Serpentine results in increased expression of HSD11B1 mRNA
Asbestos, Serpentine results in decreased expression of HSD11B1 mRNA

PMID:16251409 PMID:24160326

NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687

G

heat shock transcription factor 4

decreases methylation

Asbestos, Serpentine results in decreased methylation of HSF4 promoter

NCBI chr19:33,147,755...33,153,479
Ensembl chr19:33,147,755...33,153,479

G

heat shock protein 90 beta family member 1

increases expression

Asbestos, Serpentine results in increased expression of HSP90B1 mRNA

NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788

G

heat shock protein family A (Hsp70) member 2

decreases expression

Asbestos, Serpentine results in decreased expression of HSPA2 mRNA

NCBI chr 6:95,128,504...95,131,281
Ensembl chr 6:95,128,350...95,131,287

G

heat shock protein family A (Hsp70) member 4

increases methylation

Asbestos, Serpentine results in increased methylation of HSPA4 5' UTR

NCBI chr10:37,408,025...37,449,080
Ensembl chr10:37,408,025...37,449,001

G

heat shock protein family A (Hsp70) member 5

increases expression

Asbestos, Serpentine results in increased expression of HSPA5 mRNA; Asbestos, Serpentine results in increased expression of HSPA5 protein

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

HtrA serine peptidase 1

decreases methylation

Asbestos, Serpentine results in decreased methylation of HTRA1 gene

NCBI chr 1:185,497,815...185,547,380
Ensembl chr 1:185,497,735...185,547,379

G

intercellular adhesion molecule 5

decreases methylation

Asbestos, Serpentine results in decreased methylation of ICAM5 5' UTR

NCBI chr 8:19,567,390...19,575,588
Ensembl chr 8:19,568,600...19,575,588

G

interferon-induced protein 44

decreases expression

Asbestos, Serpentine results in decreased expression of IFI44 mRNA

NCBI chr 2:240,626,058...240,643,879
Ensembl chr 2:240,626,066...240,643,844

G

interferon-induced protein with tetratricopeptide repeats 2

decreases expression

Asbestos, Serpentine results in decreased expression of IFIT2 mRNA

PMID:21148743 PMID:29523930

NCBI chr 1:232,102,570...232,108,638
Ensembl chr 1:232,102,570...232,108,635

G

interferon-induced protein with tetratricopeptide repeats 3

increases expression
decreases expression

Asbestos, Serpentine results in increased expression of IFIT3 mRNA
Asbestos, Serpentine results in decreased expression of IFIT3 mRNA

PMID:24160326 PMID:29523930

NCBI chr 1:232,114,166...232,119,311
Ensembl chr 1:232,114,166...232,119,307

G

interferon induced transmembrane protein 1

increases expression

Asbestos, Serpentine results in increased expression of IFITM1 mRNA

NCBI chr 1:196,067,163...196,069,169
Ensembl chr 1:196,067,963...196,069,169

G

interferon gamma

decreases expression
multiple interactions

Asbestos, Serpentine results in decreased expression of IFNG protein
[Asbestos, Serpentine results in decreased susceptibility to Asbestos, Serpentine] which results in decreased expression of IFNG protein

PMID:21148743 PMID:22608188 PMID:23449737

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interferon gamma receptor 2

affects expression

Asbestos, Serpentine affects the expression of IFNGR2 mRNA

NCBI chr11:30,779,733...30,798,005
Ensembl chr11:30,779,733...30,798,005

G

insulin-like growth factor 1

increases expression

Asbestos, Serpentine results in increased expression of IGF1 mRNA

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

insulin-like growth factor 2

increases expression

Asbestos, Serpentine results in increased expression of IGF2 mRNA

NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018

G

insulin-like growth factor 2 mRNA binding protein 2

increases expression

Asbestos, Serpentine results in increased expression of IGF2BP2 mRNA

NCBI chr11:78,874,402...78,974,392
Ensembl chr11:78,874,414...78,974,377

G

insulin-like growth factor binding protein 3

increases expression

Asbestos, Serpentine results in increased expression of IGFBP3 mRNA

NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083

G

insulin-like growth factor binding protein 6

decreases expression

Asbestos, Serpentine results in decreased expression of IGFBP6 mRNA

PMID:16251409 PMID:29523930

NCBI chr 7:133,276,309...133,280,944
Ensembl chr 7:133,276,234...133,280,966

G

interleukin 10

decreases expression
multiple interactions
increases expression

Asbestos, Serpentine results in decreased expression of IL10 protein
[Asbestos, Serpentine results in decreased susceptibility to Asbestos, Serpentine] which results in increased expression of IL10 protein
Asbestos, Serpentine results in increased expression of IL10 protein
PRKDC affects the reaction [Asbestos, Serpentine results in increased expression of IL10 protein]

PMID:17200189 PMID:22608188 PMID:23449737

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 12B

increases expression
multiple interactions

Asbestos, Serpentine results in increased expression of IL12B protein
PRKDC affects the reaction [Asbestos, Serpentine results in increased expression of IL12B protein]; SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in increased expression of IL12B protein]

PMID:17200189 PMID:18403674 PMID:21514415

NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903

G

interleukin 13

increases expression
multiple interactions

Asbestos, Serpentine results in increased expression of IL13 protein
PRKDC affects the reaction [Asbestos, Serpentine results in increased expression of IL13 protein]

NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737

G

interleukin 18

decreases expression

Asbestos, Serpentine results in decreased expression of IL18 mRNA

NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887

G

interleukin 19

increases expression

Asbestos, Serpentine results in increased expression of IL19 mRNA

NCBI chr13:42,397,715...42,411,637
Ensembl chr13:42,399,138...42,405,473

G

interleukin 1 alpha

increases expression
multiple interactions

Asbestos, Serpentine results in increased expression of IL1A protein
Asbestos, Serpentine results in increased expression of IL1A mRNA
[Asbestos, Serpentine co-treated with Lipopolysaccharides] results in increased expression of IL1A mRNA

PMID:9400719 PMID:17200189 PMID:24160326

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

increases expression
multiple interactions
increases secretion

Asbestos, Serpentine results in increased expression of IL1B mRNA
[Asbestos, Serpentine co-treated with IL1B protein] results in increased abundance of 3-nitrotyrosine; [Asbestos, Serpentine co-treated with IL1B protein] results in increased abundance of Nitrates; [Asbestos, Serpentine co-treated with IL1B protein] results in increased expression of NOS2 mRNA; [Asbestos, Serpentine co-treated with IL1B protein] results in increased expression of NOS2 protein; [Asbestos, Serpentine results in increased secretion of IL1B protein] which results in increased phosphorylation of MAP3K8 protein; [Asbestos, Serpentine results in increased secretion of IL1B protein] which results in increased phosphorylation of MAPK1 protein; [Asbestos, Serpentine results in increased secretion of IL1B protein] which results in increased phosphorylation of MAPK3 protein; [Asbestos, Serpentine results in increased secretion of IL1B protein] which results in increased phosphorylation of RELA protein; Asbestos, Serpentine promotes the reaction [IL1B protein results in increased abundance of Nitric Oxide]; Cytochalasin B inhibits the reaction [Asbestos, Serpentine promotes the reaction [IL1B protein results in increased abundance of Nitric Oxide]]; IL1RN protein inhibits the reaction [[Asbestos, Serpentine results in increased secretion of IL1B protein] which results in increased secretion of IL6 protein]; pimagedine inhibits the reaction [Asbestos, Serpentine promotes the reaction [IL1B protein results in increased abundance of Nitric Oxide]]; tyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone analog inhibits the reaction [Asbestos, Serpentine results in increased secretion of IL1B protein]
[Asbestos, Serpentine results in increased secretion of IL1B protein] which results in increased secretion of CSF2 protein; [Asbestos, Serpentine results in increased secretion of IL1B protein] which results in increased secretion of FGF2 protein; [Asbestos, Serpentine results in increased secretion of IL1B protein] which results in increased secretion of IL6 protein; Asbestos, Serpentine results in increased secretion of IL1B protein
Asbestos, Serpentine results in increased expression of IL1B mRNA; Asbestos, Serpentine results in increased expression of IL1B protein
Asbestos, Serpentine promotes the reaction [IL1B protein results in increased expression of VCAM1 mRNA]; Asbestos, Serpentine promotes the reaction [IL1B protein results in increased expression of VCAM1 protein]; IL1B protein promotes the reaction [Asbestos, Serpentine results in increased expression of CCL2 mRNA]; IL1B protein promotes the reaction [Asbestos, Serpentine results in increased secretion of CCL2 protein]
NLRP3 protein affects the reaction [Asbestos, Serpentine results in increased expression of IL1B protein]; SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in increased expression of IL1B protein]

PMID:8473757 PMID:9698594 PMID:10444523 PMID:10923243 PMID:16251409 More...

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 1 receptor-like 1

increases expression

Asbestos, Serpentine results in increased expression of IL1RL1 mRNA

PMID:23917077 PMID:24160326

NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256

G

interleukin 1 receptor antagonist

increases secretion
multiple interactions
increases expression

Asbestos, Serpentine results in increased secretion of IL1RN protein
IL1RN protein inhibits the reaction [[Asbestos, Serpentine results in increased secretion of IL1B protein] which results in increased secretion of IL6 protein]
Asbestos, Serpentine results in increased expression of IL1RN mRNA

PMID:23017228 PMID:24160326

NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445

G

interleukin 2

increases secretion

Asbestos, Serpentine results in increased secretion of IL2 protein

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 24

increases expression

Asbestos, Serpentine results in increased expression of IL24 mRNA

NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487

G

interleukin 4

increases expression
multiple interactions

Asbestos, Serpentine results in increased expression of IL4 mRNA; Asbestos, Serpentine results in increased expression of IL4 protein
PRKDC affects the reaction [Asbestos, Serpentine results in increased expression of IL4 protein]; PRKDC protein affects the reaction [Asbestos, Serpentine results in increased expression of IL4 mRNA]; SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in increased expression of IL4 protein]

PMID:16251409 PMID:17200189 PMID:21514415

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 5

increases expression
multiple interactions

Asbestos, Serpentine results in increased expression of IL5 protein
PRKDC affects the reaction [Asbestos, Serpentine results in increased expression of IL5 protein]

PMID:16251409 PMID:17200189 PMID:21514415

NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213

G

interleukin 6

increases secretion
multiple interactions
increases expression

[Asbestos, Serpentine results in increased secretion of IL1B protein] which results in increased secretion of IL6 protein; Asbestos, Serpentine results in increased secretion of IL6 protein
IL1RN protein inhibits the reaction [[Asbestos, Serpentine results in increased secretion of IL1B protein] which results in increased secretion of IL6 protein]
Asbestos, Serpentine results in increased expression of IL6 mRNA; Asbestos, Serpentine results in increased expression of IL6 protein
SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in increased expression of IL6 protein]
[Asbestos, Serpentine co-treated with Lipopolysaccharides] results in increased expression of IL6 mRNA

PMID:9400719 PMID:15790520 PMID:16251409 PMID:17200189 PMID:21514415 More...

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

interleukin 6 cytokine family signal transducer

increases expression

Asbestos, Serpentine results in increased expression of IL6ST mRNA

NCBI chr 2:44,065,979...44,106,255
Ensembl chr 2:44,066,130...44,109,936

G

interleukin 7 receptor

increases expression

Asbestos, Serpentine results in increased expression of IL7R mRNA

PMID:16251409 PMID:24160326

NCBI chr 2:58,452,393...58,477,757
Ensembl chr 2:58,454,217...58,477,757

G

inhibin subunit beta A

decreases expression
increases expression

Asbestos, Serpentine results in decreased expression of INHBA mRNA
Asbestos, Serpentine results in increased expression of INHBA mRNA

NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982

G

IQ motif containing E

decreases methylation

Asbestos, Serpentine results in decreased methylation of IQCE gene

NCBI chr12:13,943,290...13,982,708
Ensembl chr12:13,943,487...13,982,693

G

IQ motif containing GTPase activating protein 1

increases expression

Asbestos, Serpentine results in increased expression of IQGAP1 mRNA

NCBI chr 1:134,679,581...134,769,776
Ensembl chr 1:134,679,586...134,769,755

G

interleukin-1 receptor-associated kinase 2

affects expression

Asbestos, Serpentine affects the expression of IRAK2 mRNA

NCBI chr 4:146,786,004...146,842,615
Ensembl chr 4:146,786,100...146,842,602

G

interferon regulatory factor 8

decreases expression

Asbestos, Serpentine results in decreased expression of IRF8 mRNA

NCBI chr19:48,790,581...48,812,363
Ensembl chr19:48,790,588...48,811,829

G

interferon regulatory factor 9

decreases expression

Asbestos, Serpentine results in decreased expression of IRF9 mRNA

NCBI chr15:29,095,474...29,101,924
Ensembl chr15:29,095,789...29,101,236

G

insulin receptor substrate 2

increases expression

Asbestos, Serpentine results in increased expression of IRS2 mRNA

NCBI chr16:78,488,249...78,512,482
Ensembl chr16:78,485,045...78,512,482

G

iroquois homeobox 4

increases expression

Asbestos, Serpentine results in increased expression of IRX4 mRNA

NCBI chr 1:30,030,561...30,039,549
Ensembl chr 1:30,030,561...30,039,549

G

iroquois homeobox 5

increases expression

Asbestos, Serpentine results in increased expression of IRX5 mRNA

NCBI chr19:14,639,052...14,643,911
Ensembl chr19:14,624,225...14,642,318

G

ISG15 ubiquitin-like modifier

decreases expression

Asbestos, Serpentine results in decreased expression of ISG15 mRNA

NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435

G

integrin subunit alpha X

increases expression

Asbestos, Serpentine results in increased expression of ITGAX mRNA

NCBI chr 1:182,709,653...182,740,709
Ensembl chr 1:182,719,609...182,740,698

G

integrin subunit beta 7

decreases expression

Asbestos, Serpentine results in decreased expression of ITGB7 mRNA

NCBI chr 7:133,347,927...133,364,955
Ensembl chr 7:133,347,960...133,364,876

G

integrin subunit beta 8

increases expression
decreases methylation

Asbestos, Serpentine results in increased expression of ITGB8 mRNA
Asbestos, Serpentine results in decreased methylation of ITGB8 gene

PMID:24160326 PMID:29523930 PMID:33581214

NCBI chr 6:140,125,002...140,208,261
Ensembl chr 6:140,127,203...140,208,476

G

inositol 1,4,5-trisphosphate receptor interacting protein

affects expression

Asbestos, Serpentine affects the expression of ITPRIP mRNA

NCBI chr 1:246,762,804...246,786,379
Ensembl chr 1:246,762,472...246,786,408

G

ITPRIP like 2

increases expression

Asbestos, Serpentine results in increased expression of ITPRIPL2 mRNA

NCBI chr 1:172,801,152...172,803,047
Ensembl chr 1:172,796,849...172,802,950

G

jumonji and AT-rich interaction domain containing 2

increases expression

Asbestos, Serpentine results in increased expression of JARID2 mRNA

NCBI chr17:19,777,487...19,957,696
Ensembl chr17:19,777,266...19,955,690

G

joining chain of multimeric IgA and IgM

increases expression

Asbestos, Serpentine results in increased expression of JCHAIN mRNA

NCBI chr14:19,538,927...19,547,023
Ensembl chr14:19,538,952...19,546,298

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression

Asbestos, Serpentine results in increased expression of and results in increased phosphorylation of JUN protein; PRKD1 protein affects the reaction [Asbestos, Serpentine results in increased expression of and results in increased phosphorylation of JUN protein]
Asbestos, Serpentine results in increased expression of JUN mRNA; Asbestos, Serpentine results in increased expression of JUN protein

PMID:8386370 PMID:19116364 PMID:32755622

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

potassium voltage-gated channel subfamily A member 4

increases methylation

Asbestos, Serpentine results in increased methylation of KCNA4 exon

NCBI chr 3:93,756,399...93,778,004
Ensembl chr 3:93,756,446...93,769,162

G

potassium voltage-gated channel subfamily B member 2

increases methylation

Asbestos, Serpentine results in increased methylation of KCNB2 gene

NCBI chr 5:3,567,012...4,028,564
Ensembl chr 5:3,569,685...4,028,599

G

potassium voltage-gated channel subfamily D member 2

increases methylation

Asbestos, Serpentine results in increased methylation of KCND2 gene

NCBI chr 4:49,775,812...50,277,746
Ensembl chr 4:49,776,246...50,277,728

G

potassium two pore domain channel subfamily K member 2

decreases methylation

Asbestos, Serpentine results in decreased methylation of KCNK2 gene

NCBI chr13:100,766,101...100,963,435
Ensembl chr13:100,766,113...100,963,435

G

potassium channel tetramerization domain containing 12

decreases expression

Asbestos, Serpentine results in decreased expression of KCTD12 mRNA

NCBI chr15:79,800,078...79,806,017
Ensembl chr15:79,801,191...79,806,282

G

lysine demethylase 6B

increases expression
multiple interactions
affects expression

Asbestos, Serpentine results in increased expression of KDM6B mRNA
Asbestos, Serpentine promotes the reaction [KDM6B protein affects the expression of TNF mRNA]; Asbestos, Serpentine promotes the reaction [STAT6 protein binds to KDM6B promoter]; KDM6B protein affects the reaction [Asbestos, Serpentine results in increased expression of RETNLA mRNA]; KDM6B protein affects the reaction [Asbestos, Serpentine results in increased expression of TNF mRNA]; leflunomide inhibits the reaction [Asbestos, Serpentine results in increased expression of KDM6B mRNA]; STAT6 protein affects the reaction [Asbestos, Serpentine affects the expression of KDM6B mRNA]

NCBI chr10:54,120,716...54,142,212
Ensembl chr10:54,121,848...54,130,794

G

kinesin family member 20A

increases expression

Asbestos, Serpentine results in increased expression of KIF20A mRNA

NCBI chr18:26,230,294...26,238,780
Ensembl chr18:26,230,230...26,238,780

G

KLF transcription factor 12

decreases methylation

Asbestos, Serpentine results in decreased methylation of KLF12 5' UTR

NCBI chr15:76,628,778...77,062,000
Ensembl chr15:76,637,654...77,062,056

G

kelch-like family member 36

decreases methylation

Asbestos, Serpentine results in decreased methylation of KLHL36 gene

NCBI chr19:47,921,590...47,942,627
Ensembl chr19:47,921,590...47,942,620

G

kallikrein 1

increases activity

Asbestos, Serpentine results in increased activity of KLK1 protein

NCBI chr 1:94,642,644...94,646,760
Ensembl chr 1:94,642,687...94,646,754

G

killer cell lectin like receptor K1

decreases expression

Asbestos, Serpentine results in decreased expression of KLRK1 protein

NCBI chr 4:163,079,887...163,092,434
Ensembl chr 4:163,081,927...163,092,459

G

keratin 17

decreases expression

Asbestos, Serpentine results in decreased expression of KRT17 mRNA

NCBI chr10:85,178,673...85,183,392
Ensembl chr10:85,178,675...85,183,392

G

keratin 18

decreases expression

Asbestos, Serpentine results in decreased expression of KRT18 mRNA

NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166

G

keratin 19

decreases expression

Asbestos, Serpentine results in decreased expression of KRT19 mRNA

NCBI chr10:85,075,835...85,080,552
Ensembl chr10:85,066,802...85,171,799

G

keratin 81

increases expression

Asbestos, Serpentine results in increased expression of KRT81 mRNA

NCBI chr 7:132,577,112...132,582,238
Ensembl chr 7:132,576,492...132,582,170

G

kynureninase

increases expression

Asbestos, Serpentine results in increased expression of KYNU mRNA

NCBI chr 3:27,778,646...27,929,470
Ensembl chr 3:27,778,772...27,929,488

G

L3MBTL histone methyl-lysine binding protein 1

decreases methylation

Asbestos, Serpentine results in decreased methylation of L3MBTL1 5' UTR

NCBI chr 3:151,597,903...151,633,657
Ensembl chr 3:151,602,980...151,631,233

G

laminin subunit gamma 1

increases methylation

Asbestos, Serpentine results in increased methylation of LAMC1 gene

NCBI chr13:65,374,372...65,501,492
Ensembl chr13:65,374,372...65,501,492

G

laminin subunit gamma 2

increases expression

Asbestos, Serpentine results in increased expression of LAMC2 mRNA

NCBI chr13:65,284,664...65,344,164
Ensembl chr13:65,284,664...65,344,200

G

lipocalin 2

increases expression

Asbestos, Serpentine results in increased expression of LCN2 mRNA

NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095

G

lactate dehydrogenase B

increases methylation

Asbestos, Serpentine results in increased methylation of LDHB gene

NCBI chr 4:175,428,382...175,446,403
Ensembl chr 4:175,428,385...175,446,403

G

low density lipoprotein receptor class A domain containing 4

increases methylation

Asbestos, Serpentine results in increased methylation of LDLRAD4 5' UTR

NCBI chr18:61,519,253...61,848,403
Ensembl chr18:61,521,428...61,843,238

G

leptin

decreases expression

Asbestos, Serpentine results in decreased expression of LEP mRNA

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

G

LIM homeobox 2

decreases methylation

Asbestos, Serpentine results in decreased methylation of LHX2 promoter

NCBI chr 3:22,113,619...22,143,909
Ensembl chr 3:22,126,007...22,143,908

G

LIM homeobox 8

decreases methylation

Asbestos, Serpentine results in decreased methylation of LHX8 gene

NCBI chr 2:243,244,958...243,269,624
Ensembl chr 2:243,244,961...243,269,416

G

LIF, interleukin 6 family cytokine

decreases expression

Asbestos, Serpentine results in decreased expression of LIF mRNA

NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482

G

LIM domain only 3

decreases methylation

Asbestos, Serpentine results in decreased methylation of LMO3 5' UTR

NCBI chr 4:171,234,686...171,297,677
Ensembl chr 4:171,234,696...171,292,222

G

LIM domain 7

increases methylation

Asbestos, Serpentine results in increased methylation of LMO7 exon

NCBI chr15:78,566,999...78,769,833
Ensembl chr15:78,567,023...78,769,783

G

leiomodin 2

decreases methylation

Asbestos, Serpentine results in decreased methylation of LMOD2 3' UTR

NCBI chr 4:53,067,428...53,075,124
Ensembl chr 4:53,067,428...53,075,120

G

LIM homeobox transcription factor 1 alpha

decreases methylation

Asbestos, Serpentine results in decreased methylation of LMX1A gene

NCBI chr13:79,834,614...79,978,253
Ensembl chr13:79,835,019...79,978,253

G

U6 spliceosomal RNA

increases expression

Asbestos, Serpentine results in increased expression of RNU6-1 mRNA

NCBI chr 8:63,594,040...63,594,146
Ensembl chr 8:63,594,040...63,594,146

G

U1 spliceosomal RNA

increases expression

Asbestos, Serpentine results in increased expression of RNVU1-7 mRNA

NCBI chr18:79,901,335...79,901,477
Ensembl chr18:79,901,335...79,901,477
Ensembl chr18:79,901,335...79,901,477

G

5S ribosomal RNA

increases expression

Asbestos, Serpentine results in increased expression of RNA5S9 mRNA

NCBI chr19:51,610,075...51,610,193
Ensembl chr19:51,610,075...51,610,193

G

lysyl oxidase-like 2

decreases methylation

Asbestos, Serpentine results in decreased methylation of LOXL2 5' UTR

NCBI chr15:44,683,449...44,773,067
Ensembl chr15:44,683,880...44,773,067

G

leucine rich repeat containing 2

increases expression

Asbestos, Serpentine results in increased expression of LRRC2 mRNA

NCBI chr 8:110,936,119...110,969,189
Ensembl chr 8:110,938,165...110,969,185

G

leucine rich repeat containing 66

decreases methylation

Asbestos, Serpentine results in decreased methylation of LRRC66 3' UTR

NCBI chr14:34,578,934...34,604,977
Ensembl chr14:34,581,240...34,604,541

G

leukocyte receptor tyrosine kinase

decreases methylation

Asbestos, Serpentine results in decreased methylation of LTK promoter

NCBI chr 3:106,734,675...106,741,552
Ensembl chr 3:106,734,676...106,743,369

G

leucine zipper protein 1

affects expression

Asbestos, Serpentine affects the expression of LUZP1 mRNA

NCBI chr 5:148,706,094...148,781,616
Ensembl chr 5:148,706,138...148,781,609

G

macrophage immunometabolism regulator

decreases expression

Asbestos, Serpentine results in decreased expression of MACIR mRNA

NCBI chr 9:98,420,760...98,440,818
Ensembl chr 9:98,420,376...98,441,733

G

mal, T-cell differentiation protein

increases expression

Asbestos, Serpentine results in increased expression of MAL mRNA

NCBI chr 3:114,864,378...114,888,136
Ensembl chr 3:114,864,378...114,888,136

G

microtubule-associated protein 1 light chain 3 beta

increases expression

Asbestos, Serpentine results in increased expression of MAP1LC3B mRNA

NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690

G

mitogen activated protein kinase kinase 1

affects expression

Asbestos, Serpentine affects the expression of MAP2K1 mRNA

NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147

G

mitogen activated protein kinase kinase kinase 12

decreases methylation

Asbestos, Serpentine results in decreased methylation of MAP3K12 promoter

NCBI chr 7:133,630,267...133,648,464
Ensembl chr 7:133,630,835...133,640,789

G

mitogen activated protein kinase kinase kinase 4

decreases methylation

Asbestos, Serpentine results in decreased methylation of MAP3K4 promoter

NCBI chr 1:48,431,801...48,519,358
Ensembl chr 1:48,431,830...48,519,358

G

mitogen-activated protein kinase kinase kinase 6

decreases methylation

Asbestos, Serpentine results in decreased methylation of MAP3K6 promoter

NCBI chr 5:145,440,126...145,452,213
Ensembl chr 5:145,440,346...145,452,212

G

mitogen-activated protein kinase kinase kinase 8

increases phosphorylation
multiple interactions

Asbestos, Serpentine results in increased phosphorylation of MAP3K8 protein
[Asbestos, Serpentine results in increased secretion of IL1B protein] which results in increased phosphorylation of MAP3K8 protein

NCBI chr17:53,382,908...53,403,216
Ensembl chr17:53,383,131...53,403,216

G

mitogen activated protein kinase 1

multiple interactions
increases phosphorylation
decreases phosphorylation

[Asbestos, Serpentine results in increased secretion of IL1B protein] which results in increased phosphorylation of MAPK1 protein
Asbestos, Serpentine results in increased phosphorylation of MAPK1 protein
Asbestos, Serpentine results in decreased phosphorylation of MAPK1 protein
Asbestos, Serpentine promotes the reaction [MAPK1 protein binds to PRKD1 protein]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Asbestos, Serpentine results in increased phosphorylation of MAPK1 protein]; PRKD1 protein affects the reaction [Asbestos, Serpentine results in increased phosphorylation of MAPK1 protein]
[Asbestos, Serpentine results in increased phosphorylation of MAPK1 protein] which results in increased phosphorylation of ELK1 protein; Asbestos, Serpentine results in increased phosphorylation of MAPK1 protein

PMID:10751356 PMID:12495932 PMID:16571779 PMID:19116364 PMID:23017228 More...

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 14

increases phosphorylation

Asbestos, Serpentine results in increased phosphorylation of MAPK14 protein

NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589

G

mitogen activated protein kinase 3

decreases phosphorylation
multiple interactions
increases phosphorylation

Asbestos, Serpentine results in decreased phosphorylation of MAPK3 protein
[Asbestos, Serpentine results in increased secretion of IL1B protein] which results in increased phosphorylation of MAPK3 protein
Asbestos, Serpentine promotes the reaction [MAPK3 protein binds to PRKD1 protein]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Asbestos, Serpentine results in increased phosphorylation of MAPK3 protein]; PRKD1 protein affects the reaction [Asbestos, Serpentine results in increased phosphorylation of MAPK3 protein]
[Asbestos, Serpentine results in increased phosphorylation of MAPK3 protein] which results in increased phosphorylation of ELK1 protein; Asbestos, Serpentine results in increased phosphorylation of MAPK3 protein

PMID:10751356 PMID:12495932 PMID:16571779 PMID:19116364 PMID:23017228 More...

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

multiple interactions
increases phosphorylation

Acetylcysteine inhibits the reaction [Asbestos, Serpentine results in increased phosphorylation of MAPK8 protein]

PMID:15882436 PMID:24735948

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

mitogen-activated protein kinase 9

multiple interactions
increases phosphorylation

Acetylcysteine inhibits the reaction [Asbestos, Serpentine results in increased phosphorylation of MAPK9 protein]

NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178

G

microtubule-associated protein tau

decreases expression

Asbestos, Serpentine results in decreased expression of MAPT mRNA

NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129

G

membrane associated ring-CH-type finger 3

decreases expression

Asbestos, Serpentine results in decreased expression of MARCHF3 mRNA

NCBI chr18:50,237,218...50,389,343
Ensembl chr18:50,237,230...50,389,150

G

myoglobin

decreases expression
multiple interactions

Asbestos, Serpentine results in decreased expression of MB mRNA
SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in decreased expression of MB mRNA]

NCBI chr 7:108,759,903...108,767,134
Ensembl chr 7:108,759,904...108,767,383

G

muscleblind-like splicing regulator 1

increases methylation

Asbestos, Serpentine results in increased methylation of MBNL1 exon

NCBI chr 2:144,639,819...144,814,395
Ensembl chr 2:144,670,285...144,814,368

G

melanoma cell adhesion molecule

increases expression

Asbestos, Serpentine results in increased expression of MCAM mRNA

NCBI chr 8:44,479,391...44,487,575
Ensembl chr 8:44,479,376...44,487,571

G

MCF.2 cell line derived transforming sequence-like

decreases methylation

Asbestos, Serpentine results in decreased methylation of MCF2L promoter

NCBI chr16:76,507,133...76,652,893
Ensembl chr16:76,507,133...76,652,733

G

mediator complex subunit 19

increases expression

Asbestos, Serpentine results in increased expression of MED19 mRNA

NCBI chr 3:69,762,138...69,772,661
Ensembl chr 3:69,762,166...69,772,036

G

MER proto-oncogene, tyrosine kinase

decreases expression

Asbestos, Serpentine results in decreased expression of MERTK mRNA

NCBI chr 3:115,939,351...116,045,141
Ensembl chr 3:115,939,351...116,046,554

G

major facilitator superfamily domain containing 4A

decreases methylation

Asbestos, Serpentine results in decreased methylation of MFSD4A 5' UTR

NCBI chr13:43,469,488...43,510,467
Ensembl chr13:43,469,488...43,510,467

G

MGAT4 family, member C

increases methylation

Asbestos, Serpentine results in increased methylation of MGAT4C 5' UTR

NCBI chr 7:36,709,564...37,485,810
Ensembl chr 7:37,260,321...37,474,571

G

microsomal glutathione S-transferase 1

increases expression

Asbestos, Serpentine results in increased expression of MGST1 mRNA

NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892

G

MIA SH3 domain ER export factor 3

increases expression

Asbestos, Serpentine results in increased expression of MIA3 mRNA

NCBI chr13:94,970,421...95,012,071
Ensembl chr13:94,970,424...95,011,972

G

migration and invasion inhibitory protein

increases methylation

Asbestos, Serpentine results in increased methylation of MIIP 5' UTR

NCBI chr 5:158,292,510...158,299,533
Ensembl chr 5:158,292,511...158,299,694

G

microRNA 129-2

increases methylation

Asbestos, Serpentine results in increased methylation of MIR129-2 5' UTR

NCBI chr 3:80,202,044...80,202,140
Ensembl chr 3:80,202,044...80,202,140

G

microRNA 30d

decreases expression

Asbestos, Serpentine results in decreased expression of MIR30D mRNA

NCBI chr 7:100,136,391...100,136,472
Ensembl chr 7:100,136,391...100,136,472

G

marker of proliferation Ki-67

increases expression
multiple interactions

Asbestos, Serpentine results in increased expression of MKI67 protein
[MPO protein affects the susceptibility to Asbestos, Serpentine] which affects the expression of MKI67 protein; PRKDC protein affects the reaction [Asbestos, Serpentine results in increased expression of MKI67 protein]

PMID:16266986 PMID:17200189

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

MAPK interacting serine/threonine kinase 2

decreases methylation

Asbestos, Serpentine results in decreased methylation of MKNK2 promoter

NCBI chr 7:9,039,771...9,050,832
Ensembl chr 7:9,039,728...9,050,827

G

matrix metallopeptidase 1

increases expression

Asbestos, Serpentine results in increased expression of MMP1 mRNA

NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097

G

matrix metallopeptidase 10

increases expression

Asbestos, Serpentine results in increased expression of MMP10 mRNA

NCBI chr 8:4,689,840...4,697,748
Ensembl chr 8:4,689,840...4,697,748

G

matrix metallopeptidase 12

multiple interactions
increases activity
increases expression

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Asbestos, Serpentine results in increased expression of MMP12 mRNA]; PRKDC protein affects the reaction [Asbestos, Serpentine results in increased expression of MMP12 mRNA]; rottlerin inhibits the reaction [Asbestos, Serpentine results in increased expression of MMP12 mRNA]; U 0126 inhibits the reaction [Asbestos, Serpentine results in increased expression of MMP12 mRNA]
Asbestos, Serpentine results in increased activity of MMP12 protein

PMID:16251409 PMID:16571779

NCBI chr 8:4,581,785...4,591,687
Ensembl chr 8:4,581,785...4,599,611

G

matrix metallopeptidase 13

multiple interactions
increases expression

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Asbestos, Serpentine results in increased expression of MMP13 mRNA]; PRKDC protein affects the reaction [Asbestos, Serpentine results in increased expression of MMP13 mRNA]; rottlerin inhibits the reaction [Asbestos, Serpentine results in increased expression of MMP13 mRNA]; RTKI cpd inhibits the reaction [Asbestos, Serpentine results in increased expression of MMP13 mRNA]; U 0126 inhibits the reaction [Asbestos, Serpentine results in increased expression of MMP13 mRNA]

PMID:16571779 PMID:23917077

NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239

G

matrix metallopeptidase 14

increases expression

Asbestos, Serpentine results in increased expression of MMP14 mRNA

NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864

G

matrix metallopeptidase 2

increases secretion
increases activity

Asbestos, Serpentine results in increased secretion of MMP2 protein
Asbestos, Serpentine results in increased activity of MMP2 protein

PMID:16571779 PMID:26685284 PMID:30609805

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 20

increases expression

Asbestos, Serpentine results in increased expression of MMP20 mRNA

NCBI chr 8:4,789,415...4,830,035
Ensembl chr 8:4,789,415...4,830,035

G

matrix metallopeptidase 3

increases expression
decreases expression

Asbestos, Serpentine results in increased expression of MMP3 mRNA
Asbestos, Serpentine results in decreased expression of MMP3 mRNA

PMID:16251409 PMID:23917077 PMID:24160326

NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961

G

matrix metallopeptidase 7

increases expression
increases secretion

Asbestos, Serpentine results in increased expression of MMP7
Asbestos, Serpentine results in increased secretion of MMP7 protein
Asbestos, Serpentine results in increased expression of MMP7 mRNA

PMID:19105532 PMID:33581214

NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902

G

matrix metallopeptidase 9

increases secretion
increases activity
increases expression

Asbestos, Serpentine results in increased secretion of MMP9 protein
Asbestos, Serpentine results in increased activity of MMP9 protein
Asbestos, Serpentine results in increased expression of MMP9; Asbestos, Serpentine results in increased expression of MMP9 mRNA

PMID:16571779 PMID:18039278 PMID:19105532 PMID:26685284

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

myeloid cell nuclear differentiation antigen

decreases expression

Asbestos, Serpentine results in decreased expression of MNDA mRNA

NCBI chr13:86,017,888...86,035,556
Ensembl chr13:86,017,892...86,034,201

G

myeloperoxidase

increases expression
affects response to substance
multiple interactions

Asbestos, Serpentine results in increased expression of MPO protein
MPO protein affects the susceptibility to Asbestos, Serpentine
[MPO protein affects the susceptibility to Asbestos, Serpentine] which affects the expression of CCND1 protein; [MPO protein affects the susceptibility to Asbestos, Serpentine] which affects the expression of MKI67 protein

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

MAS related GPR family member X3

affects expression

Asbestos, Serpentine affects the expression of MRGPRX3 mRNA

NCBI chr 1:97,720,377...97,746,953
Ensembl chr 1:97,721,436...97,746,900

G

mesothelin

increases expression

Asbestos, Serpentine results in increased expression of MSLN protein

NCBI chr10:14,771,946...14,781,382
Ensembl chr10:14,771,961...14,777,643

G

methionine sulfoxide reductase B1

increases methylation

Asbestos, Serpentine results in increased methylation of MSRB1 gene

NCBI chr10:13,764,883...13,770,609
Ensembl chr10:13,764,883...13,770,609

G

metallothionein 1

increases expression

Asbestos, Serpentine results in increased expression of MT1 mRNA

NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049

G

microtubule crosslinking factor 2

decreases expression

Asbestos, Serpentine results in decreased expression of MTCL2 mRNA

NCBI chr 3:145,669,102...145,741,578
Ensembl chr 3:145,675,443...145,740,871

G

methenyltetrahydrofolate synthetase domain containing

decreases methylation

Asbestos, Serpentine results in decreased methylation of MTHFSD promoter

NCBI chr19:49,164,266...49,178,233
Ensembl chr19:49,167,183...49,178,232

G

mechanistic target of rapamycin kinase

decreases phosphorylation

Asbestos, Serpentine results in decreased phosphorylation of MTOR protein

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

MX dynamin like GTPase 1

decreases expression
increases expression

Asbestos, Serpentine results in decreased expression of MX1 mRNA
Asbestos, Serpentine results in increased expression of MX1 mRNA

PMID:24160326 PMID:29523930

NCBI chr11:36,799,659...36,825,209
Ensembl chr11:36,799,660...36,823,507

G

max dimerization protein 1

increases expression

Asbestos, Serpentine results in increased expression of MXD1 mRNA

NCBI chr 4:119,097,353...119,118,080
Ensembl chr 4:119,097,353...119,117,751

G

MYC proto-oncogene, bHLH transcription factor

multiple interactions
increases expression

aluminum citrate inhibits the reaction [Asbestos, Serpentine results in increased expression of MYC mRNA]; Sodium Selenite inhibits the reaction [Asbestos, Serpentine results in increased expression of MYC mRNA]

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

myosin, light chain 4

decreases expression

Asbestos, Serpentine results in decreased expression of MYL4 mRNA

NCBI chr10:89,449,456...89,485,365
Ensembl chr10:89,449,443...89,485,363

G

myosin light chain 7

decreases expression
multiple interactions

Asbestos, Serpentine results in decreased expression of MYL7 mRNA
SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in decreased expression of MYL7 mRNA]

PMID:21514415 PMID:29523930

NCBI chr14:80,780,684...80,783,259
Ensembl chr14:80,779,776...80,783,244

G

myosin light chain kinase 3

decreases methylation

Asbestos, Serpentine results in decreased methylation of MYLK3 promoter

NCBI chr19:21,685,085...21,743,587
Ensembl chr19:21,691,929...21,742,954

G

myozenin 2

decreases expression
multiple interactions

Asbestos, Serpentine results in decreased expression of MYOZ2 mRNA
SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in decreased expression of MYOZ2 mRNA]

NCBI chr 2:211,141,463...211,168,187
Ensembl chr 2:211,141,463...211,168,221

G

myosin VIIA and Rab interacting protein

decreases expression
multiple interactions

Asbestos, Serpentine results in decreased expression of MYRIP mRNA
SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in decreased expression of MYRIP mRNA]

NCBI chr 8:120,017,749...120,184,821
Ensembl chr 8:120,017,524...120,183,833

G

N(alpha)-acetyltransferase 16, NatA auxiliary subunit

increases methylation

Asbestos, Serpentine results in increased methylation of NAA16 3' UTR

NCBI chr15:54,711,620...54,770,915
Ensembl chr15:54,711,621...54,770,896

G

napsin A aspartic peptidase

decreases expression

Asbestos, Serpentine results in decreased expression of NAPSA mRNA

NCBI chr 1:95,064,726...95,077,101
Ensembl chr 1:95,064,900...95,077,094

G

neutrophil cytosolic factor 2

decreases expression

Asbestos, Serpentine results in decreased expression of NCF2 mRNA

NCBI chr13:64,955,622...64,986,144
Ensembl chr13:64,955,503...64,986,277

G

natural cytotoxicity triggering receptor 1

decreases expression

Asbestos, Serpentine results in decreased expression of NCR1 protein

NCBI chr 1:69,614,744...69,622,594
Ensembl chr 1:69,616,601...69,660,558

G

Nedd4 family interacting protein 1

decreases expression

Asbestos, Serpentine results in decreased expression of NDFIP1 mRNA

NCBI chr18:30,265,808...30,316,068
Ensembl chr18:30,250,613...30,322,311

G

norrin cystine knot growth factor NDP

increases expression

Asbestos, Serpentine results in increased expression of NDP mRNA

NCBI chr X:5,796,487...5,820,934
Ensembl chr X:5,796,487...5,820,934

G

N-myc downstream regulated 1

increases expression

Asbestos, Serpentine results in increased expression of NDRG1 mRNA

NCBI chr 7:98,684,487...98,725,869
Ensembl chr 7:98,684,487...98,725,880

G

nebulette

decreases methylation

Asbestos, Serpentine results in decreased methylation of NEBL gene

NCBI chr17:80,113,891...80,466,331
Ensembl chr17:80,118,543...80,466,210

G

neuraminidase 1

increases expression

Asbestos, Serpentine results in increased expression of NEU1 mRNA

NCBI chr20:3,897,480...3,901,745
Ensembl chr20:3,897,480...3,901,745

G

neuronal differentiation 2

increases methylation

Asbestos, Serpentine results in increased methylation of NEUROD2 5' UTR

NCBI chr10:83,323,801...83,327,986
Ensembl chr10:83,324,442...83,327,986

G

nuclear factor of activated T-cells 2

increases expression

Asbestos, Serpentine results in increased expression of NFATC2 mRNA

NCBI chr 3:157,195,970...157,328,640
Ensembl chr 3:157,198,872...157,328,325

G

nuclear factor I X

decreases methylation

Asbestos, Serpentine results in decreased methylation of NFIX promoter

NCBI chr19:23,355,388...23,450,360
Ensembl chr19:23,355,498...23,448,265

G

nuclear factor kappa B subunit 1

affects expression
increases expression

Asbestos, Serpentine affects the expression of NFKB1 mRNA
Asbestos, Serpentine results in increased expression of NFKB1 mRNA

PMID:10541885 PMID:24160326

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

nuclear factor kappa B subunit 2

affects expression

Asbestos, Serpentine affects the expression of NFKB2 mRNA

NCBI chr 1:245,164,586...245,173,225
Ensembl chr 1:245,165,950...245,173,213

G

NFKB inhibitor alpha

affects expression

Asbestos, Serpentine affects the expression of NFKBIA mRNA

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

NFKB inhibitor delta

decreases methylation

Asbestos, Serpentine results in decreased methylation of NFKBID promoter

NCBI chr 1:85,679,353...85,690,415
Ensembl chr 1:85,680,861...85,690,447

G

NFKB inhibitor zeta

affects expression

Asbestos, Serpentine affects the expression of NFKBIZ mRNA

NCBI chr11:44,782,676...44,810,722
Ensembl chr11:44,782,676...44,810,723

G

NHS-like 1

increases expression

Asbestos, Serpentine results in increased expression of NHSL1 mRNA

NCBI chr 1:12,956,525...13,188,580
Ensembl chr 1:12,956,021...13,187,547

G

ninein

increases expression

Asbestos, Serpentine results in increased expression of NIN mRNA

NCBI chr 6:88,525,405...88,627,710
Ensembl chr 6:88,525,742...88,627,639

G

NK3 homeobox 1

affects expression

Asbestos, Serpentine affects the expression of NKX3-1 mRNA

NCBI chr15:44,473,851...44,476,443
Ensembl chr15:44,473,851...44,476,441

G

NLR family, pyrin domain containing 3

multiple interactions

NLRP3 protein affects the reaction [Asbestos, Serpentine results in increased expression of CXCL1 protein]; NLRP3 protein affects the reaction [Asbestos, Serpentine results in increased expression of IL1B protein]

NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811

G

nitric oxide synthase 1

increases expression

Asbestos, Serpentine results in increased expression of NOS1 mRNA

NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945

G

nitric oxide synthase 2

increases expression
multiple interactions

Asbestos, Serpentine results in increased expression of NOS2 mRNA
[Asbestos, Serpentine co-treated with IL1B protein] results in increased expression of NOS2 mRNA; [Asbestos, Serpentine co-treated with IL1B protein] results in increased expression of NOS2 protein

PMID:9400719 PMID:9698594 PMID:9826428

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

NOTUM, palmitoleoyl-protein carboxylesterase

decreases methylation

Asbestos, Serpentine results in decreased methylation of NOTUM 3' UTR

NCBI chr10:105,933,245...105,940,327
Ensembl chr10:105,933,249...105,940,315

G

NPC intracellular cholesterol transporter 1

increases expression

Asbestos, Serpentine results in increased expression of NPC1 mRNA

NCBI chr18:3,379,482...3,425,100
Ensembl chr18:3,379,482...3,425,049

G

natriuretic peptide B

decreases expression

Asbestos, Serpentine results in decreased expression of NPPB mRNA

NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168

G

neuronal pentraxin 1

increases expression

Asbestos, Serpentine results in increased expression of NPTX1 mRNA

NCBI chr10:104,811,107...104,820,358
Ensembl chr10:104,811,403...104,820,367

G

nuclear receptor subfamily 4, group A, member 2

increases expression

Asbestos, Serpentine results in increased expression of NR4A2 mRNA

NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877

G

neuronal cell adhesion molecule

increases expression
multiple interactions

Asbestos, Serpentine results in increased expression of NRCAM mRNA
SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in increased expression of NRCAM mRNA]

NCBI chr 6:61,402,813...61,698,536
Ensembl chr 6:61,329,863...61,702,992

G

neuronal regeneration related protein

decreases expression

Asbestos, Serpentine results in decreased expression of NREP mRNA

NCBI chr18:25,017,069...25,046,593
Ensembl chr18:25,017,083...25,046,591

G

neuregulin 1

affects expression

Asbestos, Serpentine affects the expression of NRG1 mRNA

NCBI chr16:59,250,658...60,304,519
Ensembl chr16:59,250,854...60,296,884

G

nuclear receptor interacting protein 2

increases methylation

Asbestos, Serpentine results in increased methylation of NRIP2 5' UTR

NCBI chr 4:161,673,964...161,684,055
Ensembl chr 4:161,639,356...161,684,070

G

neuropilin 1

increases expression

Asbestos, Serpentine results in increased expression of NRP1 mRNA

NCBI chr19:56,359,455...56,514,628
Ensembl chr19:56,359,455...56,513,633

G

neurexin 3

increases methylation

Asbestos, Serpentine results in increased methylation of NRXN3 gene

NCBI chr 6:107,641,760...109,272,849
Ensembl chr 6:107,641,780...109,272,044

G

NUF2 component of NDC80 kinetochore complex

increases expression
multiple interactions

Asbestos, Serpentine results in increased expression of NUF2 mRNA
SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in increased expression of NUF2 mRNA]

NCBI chr13:81,693,675...81,722,765
Ensembl chr13:81,693,598...81,722,766

G

nucleoporin 50

increases methylation

Asbestos, Serpentine results in increased methylation of NUP50 5' UTR

NCBI chr 7:116,047,960...116,065,231
Ensembl chr 7:116,048,021...116,066,905

G

neurexophilin 1

increases methylation

Asbestos, Serpentine results in increased methylation of NXPH1 gene

NCBI chr 4:36,998,068...37,311,135
Ensembl chr 4:36,997,669...37,311,132

G

2'-5' oligoadenylate synthetase 1A

increases expression

Asbestos, Serpentine results in increased expression of OAS1 mRNA

NCBI chr12:35,669,798...35,680,505
Ensembl chr12:35,669,801...35,680,517

G

2'-5' oligoadenylate synthetase 2

increases expression

Asbestos, Serpentine results in increased expression of OAS2 mRNA

NCBI chr12:35,802,824...35,830,778
Ensembl chr12:35,806,759...35,829,371

G

2'-5'-oligoadenylate synthetase 3

increases expression

Asbestos, Serpentine results in increased expression of OAS3 mRNA

NCBI chr12:35,779,028...35,802,781
Ensembl chr12:35,779,022...35,802,781

G

2'-5'-oligoadenylate synthetase-like

increases expression
decreases expression

Asbestos, Serpentine results in increased expression of OASL mRNA
Asbestos, Serpentine results in decreased expression of OASL mRNA

PMID:24160326 PMID:29523930

NCBI chr12:41,682,900...41,695,641
Ensembl chr12:41,682,900...41,695,641

G

occludin

decreases expression

Asbestos, Serpentine results in decreased expression of OCLN protein

NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150

G

osteoglycin

decreases expression

Asbestos, Serpentine results in decreased expression of OGN mRNA

NCBI chr17:15,032,069...15,052,626
Ensembl chr17:15,032,069...15,052,739

G

olfactomedin 2

increases methylation

Asbestos, Serpentine results in increased methylation of OLFM2 gene

NCBI chr 8:19,204,472...19,282,154
Ensembl chr 8:19,204,475...19,282,117

G

oxidized low density lipoprotein receptor 1

increases expression

Asbestos, Serpentine results in increased expression of OLR1 mRNA

NCBI chr 4:162,926,436...162,949,057
Ensembl chr 4:162,926,439...162,948,523

G

one cut homeobox 1

decreases methylation

Asbestos, Serpentine results in decreased methylation of ONECUT1 promoter

NCBI chr 8:75,599,432...75,633,598
Ensembl chr 8:75,599,740...75,627,277

G

olfactory receptor family 10 subfamily AL member 6

decreases expression

Asbestos, Serpentine results in decreased expression of OR10AL6 mRNA

NCBI chr20:738,257...739,607
Ensembl chr20:734,965...811,125

G

olfactory receptor family 2 subfamily H member 2C

increases methylation

Asbestos, Serpentine results in increased methylation of OR2H2 exon

NCBI chr20:1,398,964...1,399,902
Ensembl chr20:1,395,108...1,400,441

G

otopetrin 1

decreases expression

Asbestos, Serpentine results in decreased expression of OTOP1 mRNA

NCBI chr14:72,505,036...72,532,497
Ensembl chr14:72,503,592...72,532,497

G

prolyl 4-hydroxylase subunit alpha 2

increases methylation

Asbestos, Serpentine results in increased methylation of P4HA2 5' UTR

NCBI chr10:38,243,136...38,271,983
Ensembl chr10:38,243,139...38,287,314

G

Pannexin 1

affects expression

Asbestos, Serpentine affects the expression of PANX1 mRNA

NCBI chr 8:11,851,176...11,889,774
Ensembl chr 8:11,850,730...11,889,774

G

pappalysin

increases expression

Asbestos, Serpentine results in increased expression of PAPPA mRNA

NCBI chr 5:78,497,660...78,735,873
Ensembl chr 5:78,498,300...78,730,666

G

prostate androgen-regulated mucin-like protein 1

decreases expression

Asbestos, Serpentine results in decreased expression of PARM1 mRNA

NCBI chr14:16,468,309...16,577,339
Ensembl chr14:16,468,459...16,577,314

G

paired box 2

increases methylation

Asbestos, Serpentine results in increased methylation of PAX2 gene

NCBI chr 1:243,616,509...243,697,454
Ensembl chr 1:243,616,606...243,695,321

G

PAX interacting protein 1

affects methylation

Asbestos, Serpentine affects the methylation of PAXIP1 gene

NCBI chr 4:7,525,132...7,576,659
Ensembl chr 4:7,525,004...7,576,548

G

PDZ binding kinase

increases expression
multiple interactions

Asbestos, Serpentine results in increased expression of PBK mRNA
SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in increased expression of PBK mRNA]

NCBI chr15:40,022,873...40,034,014
Ensembl chr15:40,023,002...40,034,014

G

protocadherin 9

increases methylation

Asbestos, Serpentine results in increased methylation of PCDH9 gene

NCBI chr15:69,340,108...70,237,531
Ensembl chr15:69,340,645...70,237,538

G

protocadherin alpha 1

affects methylation

Asbestos, Serpentine affects the methylation of PCDHA1 gene

Ensembl chr18:28,581,225...28,846,211

G

protocadherin alpha 10

affects methylation

Asbestos, Serpentine affects the methylation of PCDHA10 gene

Ensembl chr18:28,581,225...28,846,211

G

protocadherin alpha 11

affects methylation

Asbestos, Serpentine affects the methylation of PCDHA11 gene

Ensembl chr18:28,581,225...28,846,211

G

protocadherin alpha 12

affects methylation

Asbestos, Serpentine affects the methylation of PCDHA12 gene

Ensembl chr18:28,581,225...28,846,211

G

protocadherin alpha 13

affects methylation

Asbestos, Serpentine affects the methylation of PCDHA13 gene

Ensembl chr18:28,581,225...28,846,211

G

protocadherin alpha 2

affects methylation

Asbestos, Serpentine affects the methylation of PCDHA2 gene

Ensembl chr18:28,581,225...28,846,211

G

protocadherin alpha 3

affects methylation

Asbestos, Serpentine affects the methylation of PCDHA3 gene

Ensembl chr18:28,581,225...28,846,211

G

protocadherin alpha 4

affects methylation

Asbestos, Serpentine affects the methylation of PCDHA4 gene

NCBI chr18:28,581,040...28,846,214
Ensembl chr18:28,581,225...28,846,211

G

protocadherin alpha 5

affects methylation

Asbestos, Serpentine affects the methylation of PCDHA5 gene

Ensembl chr18:28,581,225...28,846,211

G

protocadherin alpha 6

decreases expression
affects methylation

Asbestos, Serpentine results in decreased expression of PCDHA6 mRNA
Asbestos, Serpentine affects the methylation of PCDHA6 gene

PMID:16251409 PMID:29523930

Ensembl chr18:28,581,225...28,846,211

G

protocadherin alpha 7

affects methylation

Asbestos, Serpentine affects the methylation of PCDHA7 gene

Ensembl chr18:28,581,225...28,846,211

G

protocadherin alpha 8

affects methylation

Asbestos, Serpentine affects the methylation of PCDHA8 gene

Ensembl chr18:28,581,225...28,846,211

G

protocadherin alpha 9

affects methylation

Asbestos, Serpentine affects the methylation of PCDHA9 gene

Ensembl chr18:28,581,225...28,846,211

G

protocadherin alpha subfamily C, 1

affects methylation

Asbestos, Serpentine affects the methylation of PCDHAC1 gene

NCBI chr18:28,740,353...28,750,216
Ensembl chr18:28,581,225...28,846,211

G

protocadherin alpha subfamily C, 2

affects methylation

Asbestos, Serpentine affects the methylation of PCDHAC2 5' UTR

Ensembl chr18:28,581,225...28,846,211

G

protocadherin gamma subfamily A, 4

decreases methylation

Asbestos, Serpentine results in decreased methylation of PCDHGA4 gene

NCBI chr18:29,508,152...29,543,103

G

proliferating cell nuclear antigen

increases expression

Asbestos, Serpentine results in increased expression of PCNA mRNA; Asbestos, Serpentine results in increased expression of PCNA protein

PMID:8686744 PMID:9115760

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

G

platelet derived growth factor subunit A

increases expression
multiple interactions

Asbestos, Serpentine results in increased expression of PDGFA mRNA
[TNFRSF1A gene mutant form co-treated with TNFRSF1B gene mutant form] inhibits the reaction [Asbestos, Serpentine results in increased expression of PDGFA mRNA]
Asbestos, Serpentine results in increased expression of PDGFA mRNA; Asbestos, Serpentine results in increased expression of PDGFA protein

PMID:9271299 PMID:9846974 PMID:18039278

NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497

G

platelet derived growth factor subunit B

increases expression
increases response to substance
decreases methylation

Asbestos, Serpentine results in increased expression of PDGFB mRNA
PDGFB protein results in increased susceptibility to Asbestos, Serpentine
Asbestos, Serpentine results in decreased methylation of PDGFB 5' UTR
Asbestos, Serpentine results in increased expression of PDGFB mRNA; Asbestos, Serpentine results in increased expression of PDGFB protein

PMID:9271299 PMID:15511213 PMID:18039278 PMID:29523930

NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984

G

platelet derived growth factor receptor alpha

decreases expression
increases expression

Asbestos, Serpentine results in decreased expression of PDGFRA mRNA
Asbestos, Serpentine results in increased expression of PDGFRA mRNA; Asbestos, Serpentine results in increased expression of PDGFRA protein

PMID:8392089 PMID:9603151 PMID:16251409

NCBI chr14:33,005,838...33,054,347
Ensembl chr14:33,005,839...33,054,335

G

pyruvate dehydrogenase phosphatase catalytic subunit 1

increases expression

Asbestos, Serpentine results in increased expression of PDP1 mRNA

NCBI chr 5:25,446,843...25,455,107
Ensembl chr 5:25,446,272...25,455,217

G

PDZ domain containing 2

decreases expression

Asbestos, Serpentine results in decreased expression of PDZD2 mRNA

NCBI chr 2:61,384,614...61,770,516
Ensembl chr 2:61,386,381...61,770,524

G

proliferation and apoptosis adaptor protein 15

increases expression

Asbestos, Serpentine results in increased expression of PEA15 mRNA

NCBI chr13:84,657,815...84,667,437
Ensembl chr13:84,654,870...84,667,499

G

pleckstrin homology-like domain, family B, member 1

decreases expression

Asbestos, Serpentine results in decreased expression of PHLDB1 mRNA

NCBI chr 8:45,003,543...45,051,541
Ensembl chr 8:45,003,538...45,051,522

G

phosphotyrosine interaction domain containing 1

affects expression

Asbestos, Serpentine affects the expression of PID1 mRNA

NCBI chr 9:85,284,335...85,503,035
Ensembl chr 9:85,284,335...85,503,044

G

phosphoinositide-3-kinase, regulatory subunit 5

increases expression

Asbestos, Serpentine results in increased expression of PIK3R5 mRNA

NCBI chr10:53,132,585...53,200,663
Ensembl chr10:53,132,603...53,199,374

G

Pim-1 proto-oncogene, serine/threonine kinase

decreases methylation

Asbestos, Serpentine results in decreased methylation of PIM1 promoter

NCBI chr20:7,554,921...7,559,174
Ensembl chr20:7,554,921...7,559,174

G

Pim-3 proto-oncogene, serine/threonine kinase

affects expression

Asbestos, Serpentine affects the expression of PIM3 mRNA

NCBI chr 7:119,953,377...119,956,587
Ensembl chr 7:119,953,175...119,956,587

G

plasminogen activator, urokinase

increases expression

Asbestos, Serpentine results in increased expression of PLAU mRNA

PMID:9853007 PMID:23917077

NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775

G

plasminogen activator, urokinase receptor

increases expression

Asbestos, Serpentine results in increased expression of PLAUR mRNA; Asbestos, Serpentine results in increased expression of PLAUR protein

PMID:9853007 PMID:10536123

NCBI chr 1:80,053,440...80,068,384
Ensembl chr 1:80,050,324...80,068,595

G

phospholipase C, beta 2

increases expression

Asbestos, Serpentine results in increased expression of PLCB2 mRNA

NCBI chr 3:105,683,676...105,704,384
Ensembl chr 3:105,684,815...105,704,302

G

pleckstrin homology and RhoGEF domain containing G2

decreases methylation

Asbestos, Serpentine results in decreased methylation of PLEKHG2 promoter

NCBI chr 1:83,651,902...83,665,063
Ensembl chr 1:83,647,748...83,665,063

G

perilipin 2

increases expression

Asbestos, Serpentine results in increased expression of PLIN2 mRNA

NCBI chr 5:101,156,648...101,211,738
Ensembl chr 5:101,154,411...101,242,319

G

polo-like kinase 1

increases expression

Asbestos, Serpentine results in increased expression of PLK1 mRNA

NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400

G

phospholipid phosphatase 3

affects expression

Asbestos, Serpentine affects the expression of PLPP3 mRNA

NCBI chr 5:119,927,085...120,002,206
Ensembl chr 5:119,927,085...120,002,205

G

plexin B2

increases expression

Asbestos, Serpentine results in increased expression of PLXNB2 mRNA

NCBI chr 7:120,232,276...120,258,385
Ensembl chr 7:120,232,331...120,258,330

G

peripheral myelin protein 2

increases methylation

Asbestos, Serpentine results in increased methylation of PMP2 5' UTR

NCBI chr 2:91,611,334...91,615,252
Ensembl chr 2:91,611,334...91,615,252

G

protein O-glucosyltransferase 2

increases expression

Asbestos, Serpentine results in increased expression of POGLUT2 mRNA

NCBI chr 9:46,256,388...46,268,714
Ensembl chr 9:46,256,390...46,268,532

G

POTE ankyrin domain family member 1

decreases methylation

Asbestos, Serpentine results in decreased methylation of ANKRD30A promoter

NCBI chr 3:97,641,258...97,826,965
Ensembl chr 3:97,641,261...97,826,949

G

POU class 2 homeobox 2

decreases methylation

Asbestos, Serpentine results in decreased methylation of POU2F2 promoter

NCBI chr 1:80,682,330...80,769,756
Ensembl chr 1:80,685,741...80,724,261

G

protein phosphatase, Mg2+/Mn2+ dependent, 1F

increases expression

Asbestos, Serpentine results in increased expression of PPM1F mRNA

NCBI chr11:84,064,422...84,094,410
Ensembl chr11:84,064,420...84,094,340

G

protein phosphatase 1, regulatory subunit 12C

decreases methylation

Asbestos, Serpentine results in decreased methylation of PPP1R12C promoter

NCBI chr 1:69,320,240...69,343,200
Ensembl chr 1:69,320,255...69,343,200

G

protein phosphatase 1, regulatory subunit 16B

decreases expression

Asbestos, Serpentine results in decreased expression of PPP1R16B mRNA

NCBI chr 3:147,323,652...147,419,658
Ensembl chr 3:147,324,126...147,418,937

G

protein phosphatase 2, regulatory subunit B, alpha

decreases methylation

Asbestos, Serpentine results in decreased methylation of PPP2R2A gene

NCBI chr15:41,204,659...41,263,924
Ensembl chr15:41,204,200...41,263,924

G

protein phosphatase 6, regulatory subunit 1

increases expression

Asbestos, Serpentine results in increased expression of PPP6R1 mRNA

NCBI chr 1:69,190,856...69,217,598
Ensembl chr 1:69,189,822...69,216,272

G

PEAK1 related kinase activating pseudokinase 1

decreases expression

Asbestos, Serpentine results in decreased expression of PRAG1 mRNA

NCBI chr16:56,087,885...56,141,153
Ensembl chr16:56,087,885...56,141,153

G

PR/SET domain 1

increases expression

Asbestos, Serpentine results in increased expression of PRDM1 mRNA

NCBI chr20:47,959,858...47,981,488
Ensembl chr20:47,959,858...47,981,488

G

phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1

decreases expression

Asbestos, Serpentine results in decreased expression of PREX1 mRNA

NCBI chr 3:155,306,950...155,456,688
Ensembl chr 3:155,306,950...155,456,688

G

perforin 1

decreases expression

Asbestos, Serpentine results in decreased expression of PRF1 protein

NCBI chr20:29,246,202...29,251,712
Ensembl chr20:29,246,202...29,251,701

G

protein kinase AMP-activated catalytic subunit alpha 2

decreases methylation

Asbestos, Serpentine results in decreased methylation of PRKAA2 promoter

NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543

G

protein kinase cAMP-activated catalytic subunit alpha

decreases methylation

Asbestos, Serpentine results in decreased methylation of PRKACA 3' UTR

NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430

G

protein kinase C, beta

decreases expression

Asbestos, Serpentine results in decreased expression of PRKCB mRNA

NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536

G

protein kinase C, delta

multiple interactions
decreases response to substance

Asbestos, Serpentine promotes the reaction [PRKCD protein binds to PRKD1 protein]; PRKCD protein affects the reaction [Asbestos, Serpentine results in increased phosphorylation of PRKD1 protein]
PRKCD gene mutant form results in decreased susceptibility to Asbestos, Serpentine

NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352

G

PRKCSH beta subunit of glucosidase II

increases expression

Asbestos, Serpentine results in increased expression of PRKCSH mRNA

NCBI chr 8:20,534,787...20,546,493
Ensembl chr 8:20,534,880...20,546,492

G

protein kinase D1

multiple interactions
increases phosphorylation

Asbestos, Serpentine promotes the reaction [MAPK1 protein binds to PRKD1 protein]; Asbestos, Serpentine promotes the reaction [MAPK3 protein binds to PRKD1 protein]; Asbestos, Serpentine promotes the reaction [PRKCD protein binds to PRKD1 protein]; PRKCD protein affects the reaction [Asbestos, Serpentine results in increased phosphorylation of PRKD1 protein]; PRKD1 protein affects the reaction [Asbestos, Serpentine results in decreased expression of BCL2L11 protein]; PRKD1 protein affects the reaction [Asbestos, Serpentine results in increased expression of and results in increased phosphorylation of JUN protein]; PRKD1 protein affects the reaction [Asbestos, Serpentine results in increased phosphorylation of MAPK1 protein]; PRKD1 protein affects the reaction [Asbestos, Serpentine results in increased phosphorylation of MAPK3 protein]

NCBI chr 6:67,725,193...68,039,002
Ensembl chr 6:67,725,905...68,039,042

G

protein kinase, DNA-activated, catalytic subunit

multiple interactions

PRKDC affects the reaction [Asbestos, Serpentine results in increased expression of CCL2 protein]; PRKDC affects the reaction [Asbestos, Serpentine results in increased expression of CCL3 protein]; PRKDC affects the reaction [Asbestos, Serpentine results in increased expression of CCL5 protein]; PRKDC affects the reaction [Asbestos, Serpentine results in increased expression of CSF2 protein]; PRKDC affects the reaction [Asbestos, Serpentine results in increased expression of CXCL1 protein]; PRKDC affects the reaction [Asbestos, Serpentine results in increased expression of IL10 protein]; PRKDC affects the reaction [Asbestos, Serpentine results in increased expression of IL12B protein]; PRKDC affects the reaction [Asbestos, Serpentine results in increased expression of IL13 protein]; PRKDC affects the reaction [Asbestos, Serpentine results in increased expression of IL4 protein]; PRKDC affects the reaction [Asbestos, Serpentine results in increased expression of IL5 protein]; PRKDC protein affects the reaction [Asbestos, Serpentine results in increased expression of IL4 mRNA]; PRKDC protein affects the reaction [Asbestos, Serpentine results in increased expression of MKI67 protein]; PRKDC protein affects the reaction [Asbestos, Serpentine results in increased expression of MMP12 mRNA]; PRKDC protein affects the reaction [Asbestos, Serpentine results in increased expression of MMP13 mRNA]

PMID:16571779 PMID:17200189

NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952

G

paired related homeobox 1

affects expression

Asbestos, Serpentine affects the expression of PRRX1 mRNA

NCBI chr13:75,600,777...75,671,896
Ensembl chr13:75,601,706...75,670,866

G

proteasome 20S subunit beta 9

increases expression

Asbestos, Serpentine results in increased expression of PSMB9 mRNA

NCBI chr20:4,667,044...4,672,512
Ensembl chr20:4,666,046...4,672,512

G

prostaglandin E synthase

increases expression

Asbestos, Serpentine results in increased expression of PTGES mRNA

NCBI chr 3:14,177,892...14,189,236

G

prostaglandin E synthase 3

decreases methylation

Asbestos, Serpentine results in decreased methylation of PTGES3 gene

NCBI chr 7:490,698...507,759
Ensembl chr 7:490,656...508,084

G

prostaglandin reductase 3

increases expression
increases methylation

Asbestos, Serpentine results in increased expression of PTGR3 mRNA
Asbestos, Serpentine results in increased methylation of PTGR3 gene

PMID:21148743 PMID:29523930

NCBI chr18:77,454,435...77,463,785
Ensembl chr18:77,454,435...77,463,785

G

prostaglandin-endoperoxide synthase 2

increases expression

Asbestos, Serpentine results in increased expression of PTGS2 mRNA

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

protein tyrosine phosphatase, receptor type, N

increases expression

Asbestos, Serpentine results in increased expression of PTPRN mRNA

NCBI chr 9:76,741,010...76,756,704
Ensembl chr 9:76,741,016...76,756,190

G

protein tyrosine phosphatase, receptor type N2

increases methylation
decreases methylation

Asbestos, Serpentine results in increased methylation of PTPRN2 gene
Asbestos, Serpentine results in decreased methylation of PTPRN2 gene

NCBI chr 6:137,439,572...138,191,575
Ensembl chr 6:137,439,540...138,191,575

G

pentraxin 3

increases expression

Asbestos, Serpentine results in increased expression of PTX3 mRNA

NCBI chr 2:150,487,513...150,493,323
Ensembl chr 2:150,487,513...150,493,323

G

2-phosphoxylose phosphatase 1

decreases expression

Asbestos, Serpentine results in decreased expression of PXYLP1 mRNA

NCBI chr 8:97,419,766...97,485,163
Ensembl chr 8:97,419,776...97,485,064

G

Rac family small GTPase 1

increases activity
multiple interactions
decreases response to substance

Asbestos, Serpentine results in increased activity of RAC1 protein
RAC1 protein inhibits the reaction [Asbestos, Serpentine results in increased secretion of TNF protein]
RAC1 gene mutant form results in decreased susceptibility to Asbestos, Serpentine
RAC1 protein affects the reaction [Asbestos, Serpentine results in increased expression of TNF mRNA]; RAC1 protein inhibits the reaction [Asbestos, Serpentine results in increased secretion of TNF protein]

NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251

G

Rap1 GTPase-activating protein

increases expression

Asbestos, Serpentine results in increased expression of RAP1GAP mRNA

NCBI chr 5:149,873,987...149,939,254
Ensembl chr 5:149,892,019...149,939,253

G

Ras association (RalGDS/AF-6) and pleckstrin homology domains 1

increases expression

Asbestos, Serpentine results in increased expression of RAPH1 mRNA

NCBI chr 9:61,907,476...61,990,170
Ensembl chr 9:61,907,758...61,961,209

G

RAS p21 protein activator 3

decreases methylation

Asbestos, Serpentine results in decreased methylation of RASA3 gene

NCBI chr16:75,855,360...75,969,349
Ensembl chr16:75,855,265...75,970,804

G

RNA binding fox-1 homolog 1

increases methylation

Asbestos, Serpentine results in increased methylation of RBFOX1 gene

NCBI chr10:8,152,198...10,248,120
Ensembl chr10:8,152,198...9,686,659

G

RNA binding motif protein 12B

decreases methylation

Asbestos, Serpentine results in decreased methylation of RBM12B promoter

NCBI chr 5:25,597,405...25,610,324
Ensembl chr 5:25,590,493...25,611,245

G

RNA binding motif protein 22

increases expression

Asbestos, Serpentine results in increased expression of RBM22 mRNA

NCBI chr18:54,013,374...54,024,182
Ensembl chr18:54,013,351...54,024,569

G

RNA binding motif protein 27

decreases methylation

Asbestos, Serpentine results in decreased methylation of RBM27 promoter

NCBI chr18:34,273,527...34,336,124
Ensembl chr18:34,273,527...34,334,126

G

RNA binding motif protein 44

decreases methylation

Asbestos, Serpentine results in decreased methylation of RBM44 promoter

NCBI chr 9:91,731,153...91,756,783
Ensembl chr 9:91,731,115...91,756,772

G

RNA binding motif, single stranded interacting protein 1

increases methylation

Asbestos, Serpentine results in increased methylation of RBMS1 gene

NCBI chr 3:45,195,828...45,420,406
Ensembl chr 3:45,197,972...45,420,376

G

radixin

decreases methylation

Asbestos, Serpentine results in decreased methylation of RDX 5' UTR

NCBI chr 8:52,379,494...52,437,673
Ensembl chr 8:52,379,494...52,437,678

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

[Asbestos, Serpentine results in increased secretion of IL1B protein] which results in increased phosphorylation of RELA protein

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

riboflavin kinase

increases expression

Asbestos, Serpentine results in increased expression of RFK mRNA

NCBI chr 1:214,799,880...214,807,440
Ensembl chr 1:214,799,825...214,807,438
Ensembl chr X:214,799,825...214,807,438

G

refilin B

increases expression

Asbestos, Serpentine results in increased expression of RFLNB mRNA

NCBI chr10:60,893,693...60,899,970
Ensembl chr10:60,893,713...60,899,976

G

regulator of cell cycle

decreases expression

Asbestos, Serpentine results in decreased expression of RGCC mRNA

NCBI chr15:54,662,483...54,675,320
Ensembl chr15:54,662,483...54,681,141

G

rhomboid like 3

increases methylation

Asbestos, Serpentine results in increased methylation of RHBDL3 gene

NCBI chr10:65,299,250...65,354,099
Ensembl chr10:65,299,194...65,354,099

G

regulating synaptic membrane exocytosis 3

increases expression

Asbestos, Serpentine results in increased expression of RIMS3 mRNA

NCBI chr 5:134,429,092...134,468,935
Ensembl chr 5:134,435,829...134,640,489

G

receptor-interacting serine-threonine kinase 2

affects expression

Asbestos, Serpentine affects the expression of RIPK2 mRNA

NCBI chr 5:29,630,806...29,662,804
Ensembl chr 5:29,631,570...29,662,657

G

receptor-interacting serine-threonine kinase 3

decreases methylation

Asbestos, Serpentine results in decreased methylation of RIPK3 promoter

NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121

G

ribonuclease A family member 1, pancreatic

decreases expression

Asbestos, Serpentine results in decreased expression of RNASE1 mRNA

NCBI chr15:24,361,924...24,363,633
Ensembl chr15:24,361,927...24,363,624

G

ribonuclease A family member 2

decreases expression

Asbestos, Serpentine results in decreased expression of RNASE2 mRNA

NCBI chr15:24,449,618...24,450,427
Ensembl chr15:24,449,611...24,450,479

G

ring finger protein 19B

affects expression

Asbestos, Serpentine affects the expression of RNF19B mRNA

NCBI chr 5:141,406,085...141,431,376
Ensembl chr 5:141,406,118...141,431,380

G

ribosomal protein S6 kinase B1

decreases phosphorylation

Asbestos, Serpentine results in decreased phosphorylation of RPS6KB1 protein

NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908

G

ribonucleotide reductase regulatory subunit M2

increases expression

Asbestos, Serpentine results in increased expression of RRM2 mRNA

NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773

G

radical S-adenosyl methionine domain containing 2

increases expression

Asbestos, Serpentine results in increased expression of RSAD2 mRNA

NCBI chr 6:43,046,514...43,059,737
Ensembl chr 6:43,047,658...43,059,699

G

radial spoke head component 1

decreases expression

Asbestos, Serpentine results in decreased expression of RSPH1 mRNA

NCBI chr20:9,341,910...9,360,640
Ensembl chr20:9,341,913...9,360,640

G

RUNX family transcription factor 1

increases expression
decreases expression

Asbestos, Serpentine results in increased expression of RUNX1 mRNA
Asbestos, Serpentine results in decreased expression of RUNX1 mRNA

PMID:21148743 PMID:23917077

NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542

G

S100 calcium binding protein A16

decreases methylation

Asbestos, Serpentine results in decreased methylation of S100A16 5' UTR

NCBI chr 2:176,016,405...176,022,117
Ensembl chr 2:176,016,268...176,022,117

G

SATB homeobox 1

increases expression

Asbestos, Serpentine results in increased expression of SATB1 mRNA

NCBI chr 9:4,677,817...4,773,061
Ensembl chr 9:4,680,920...4,753,251

G

SATB homeobox 2

decreases methylation

Asbestos, Serpentine results in decreased methylation of SATB2 promoter

NCBI chr 9:58,348,027...58,534,256
Ensembl chr 9:58,350,246...58,530,707

G

secretogranin II

increases expression

Asbestos, Serpentine results in increased expression of SCG2 mRNA

NCBI chr 9:80,803,074...80,808,646
Ensembl chr 9:80,803,075...80,821,097

G

semaphorin 6A

decreases expression

Asbestos, Serpentine results in decreased expression of SEMA6A mRNA

NCBI chr18:40,050,623...40,171,954
Ensembl chr18:40,050,624...40,171,954

G

septin 1

increases expression

Asbestos, Serpentine results in increased expression of SEPTIN1 mRNA

NCBI chr 1:181,832,700...181,836,566
Ensembl chr 1:181,832,701...181,836,566

G

septin 4

decreases expression

Asbestos, Serpentine results in decreased expression of SEPTIN4 mRNA

NCBI chr10:72,366,729...72,390,764
Ensembl chr10:72,366,873...72,390,768

G

stress-associated endoplasmic reticulum protein family member 2

increases expression

Asbestos, Serpentine results in increased expression of SERP2 mRNA

NCBI chr15:51,879,882...51,903,958
Ensembl chr15:51,879,877...51,904,785

G

serpin family E member 1

decreases expression
increases expression

Asbestos, Serpentine results in decreased expression of SERPINE1 mRNA
Asbestos, Serpentine results in increased expression of SERPINE1 mRNA

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

serine-rich and transmembrane domain containing 1

increases methylation

Asbestos, Serpentine results in increased methylation of SERTM1 5' UTR

NCBI chr 2:139,086,905...139,106,528
Ensembl chr 2:139,086,908...139,106,459

G

secreted frizzled-related protein 1

increases expression

Asbestos, Serpentine results in increased expression of SFRP1 mRNA

NCBI chr16:68,575,763...68,614,180
Ensembl chr16:68,575,763...68,614,286

G

splicing factor SWAP

decreases methylation

Asbestos, Serpentine results in decreased methylation of SFSWAP gene

NCBI chr12:27,109,607...27,179,941
Ensembl chr12:27,109,611...27,179,884

G

serum/glucocorticoid regulated kinase 1

decreases methylation

Asbestos, Serpentine results in decreased methylation of SGK1 promoter

NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283

G

SH3 and multiple ankyrin repeat domains 3

increases methylation

Asbestos, Serpentine results in increased methylation of SHANK3 5' UTR

NCBI chr 7:120,568,707...120,630,796
Ensembl chr 7:120,570,402...120,630,374

G

SIGLEC family like 1

decreases methylation

Asbestos, Serpentine results in decreased methylation of SIGLECL1 3' UTR

NCBI chr 1:93,916,971...93,924,742
Ensembl chr 1:93,900,773...93,913,028
Ensembl chr 1:93,900,773...93,913,028

G

solute carrier family 10 member 1

increases expression

Asbestos, Serpentine results in increased expression of SLC10A1 mRNA

NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670

G

solute carrier family 15 member 3

decreases expression

Asbestos, Serpentine results in decreased expression of SLC15A3 mRNA

NCBI chr 1:207,492,365...207,507,158
Ensembl chr 1:207,492,365...207,507,157

G

solute carrier family 16 member 3

increases expression

Asbestos, Serpentine results in increased expression of SLC16A3 mRNA

NCBI chr10:106,212,679...106,222,564
Ensembl chr10:106,212,778...106,222,562

G

solute carrier family 1 member 5

increases expression

Asbestos, Serpentine results in increased expression of SLC1A5 mRNA

NCBI chr 1:77,456,849...77,470,952
Ensembl chr 1:77,456,694...77,470,952

G

solute carrier family 22 member 4

increases expression

Asbestos, Serpentine results in increased expression of SLC22A4 mRNA

NCBI chr10:38,133,333...38,179,932
Ensembl chr10:38,133,322...38,179,720

G

solute carrier family 25 member 33

increases methylation

Asbestos, Serpentine results in increased methylation of SLC25A33 gene

NCBI chr 5:160,195,040...160,219,961
Ensembl chr 5:160,195,042...160,219,961

G

solute carrier family 25 member 37

affects expression

Asbestos, Serpentine affects the expression of SLC25A37 mRNA

NCBI chr15:44,534,280...44,576,697
Ensembl chr15:44,536,727...44,577,199

G

solute carrier family 26 member 7

decreases methylation

Asbestos, Serpentine results in decreased methylation of SLC26A7 gene

NCBI chr 5:27,884,400...28,021,865
Ensembl chr 5:27,887,042...28,021,658

G

solute carrier family 2 member 1

increases expression

Asbestos, Serpentine results in increased expression of SLC2A1 mRNA

NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416

G

solute carrier family 2 member 3

increases expression

Asbestos, Serpentine results in increased expression of SLC2A3 mRNA

NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472

G

solute carrier family 39 member 6

increases expression

Asbestos, Serpentine results in increased expression of SLC39A6 mRNA

NCBI chr18:15,864,874...15,885,417
Ensembl chr18:15,864,875...15,885,417

G

solute carrier family 3 member 2

increases expression

Asbestos, Serpentine results in increased expression of SLC3A2 mRNA

NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931

G

solute carrier family 43, member 3

increases expression

Asbestos, Serpentine results in increased expression of SLC43A3 mRNA

NCBI chr 3:70,008,160...70,030,324
Ensembl chr 3:70,009,313...70,029,749

G

solute carrier family 45, member 4

increases expression

Asbestos, Serpentine results in increased expression of SLC45A4 mRNA

NCBI chr 7:105,478,886...105,550,160
Ensembl chr 7:105,481,792...105,550,170

G

SLC51 subunit beta

increases expression

Asbestos, Serpentine results in increased expression of SLC51B mRNA

NCBI chr 8:65,931,891...65,939,953
Ensembl chr 8:65,931,890...65,940,145

G

solute carrier family 6 member 6

decreases expression

Asbestos, Serpentine results in decreased expression of SLC6A6 mRNA

NCBI chr 4:124,195,186...124,268,880
Ensembl chr 4:124,195,218...124,268,875

G

solute carrier family 7, member 14

increases methylation

Asbestos, Serpentine results in increased methylation of SLC7A14 gene

NCBI chr 2:112,065,286...112,171,319
Ensembl chr 2:112,065,286...112,171,313

G

solute carrier family 7 member 2

affects expression

Asbestos, Serpentine affects the expression of SLC7A2 mRNA

NCBI chr16:51,417,478...51,470,784
Ensembl chr16:51,417,493...51,470,784

G

solute carrier organic anion transporter family, member 1a4

increases methylation

Asbestos, Serpentine results in increased methylation of SLCO1A2 5' UTR

NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573

G

SLIT and NTRK-like family, member 3

decreases methylation

Asbestos, Serpentine results in decreased methylation of SLITRK3 5' UTR

NCBI chr 2:157,680,067...157,697,404
Ensembl chr 2:157,687,535...157,696,709

G

secretory leukocyte peptidase inhibitor

decreases expression
increases expression

Asbestos, Serpentine results in decreased expression of SLPI mRNA
Asbestos, Serpentine results in increased expression of SLPI mRNA

NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453

G

SLX4 structure-specific endonuclease subunit

decreases methylation

Asbestos, Serpentine results in decreased methylation of SLX4 5' UTR

NCBI chr10:11,526,623...11,549,313
Ensembl chr10:11,528,424...11,549,295

G

SMAD family member 2

affects localization
multiple interactions
increases phosphorylation

Asbestos, Serpentine affects the localization of SMAD2 protein modified form
[Asbestos, Serpentine results in decreased susceptibility to Asbestos] which results in increased expression of SMAD2 mRNA; [Asbestos, Serpentine results in decreased susceptibility to Asbestos] which results in increased phosphorylation of SMAD2 protein
Asbestos, Serpentine results in increased phosphorylation of SMAD2 protein

PMID:25358858 PMID:26685284 PMID:30609805

NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323

G

SMAD family member 3

multiple interactions

[Asbestos, Serpentine results in decreased susceptibility to Asbestos] which results in decreased expression of and results in increased phosphorylation of SMAD3 protein; [Asbestos, Serpentine results in decreased susceptibility to Asbestos] which results in decreased expression of SMAD3 mRNA

NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960

G

SMAD family member 7

decreases expression

Asbestos, Serpentine results in decreased expression of SMAD7 mRNA

NCBI chr18:68,988,429...69,016,774
Ensembl chr18:68,988,429...69,016,765

G

SMAD family member 9

increases methylation

Asbestos, Serpentine results in increased methylation of SMAD9 5' UTR

NCBI chr 2:138,956,326...139,006,315
Ensembl chr 2:138,986,471...139,006,307

G

small integral membrane protein 3

affects expression

Asbestos, Serpentine affects the expression of SMIM3 mRNA

NCBI chr18:53,930,019...53,982,339
Ensembl chr18:53,930,020...53,957,416

G

spermine oxidase

affects expression

Asbestos, Serpentine affects the expression of SMOX mRNA

NCBI chr 3:118,731,814...118,767,242
Ensembl chr 3:118,731,900...118,765,710

G

snail family transcriptional repressor 1

multiple interactions
affects localization
increases expression

1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one analog inhibits the reaction [Asbestos, Serpentine affects the localization of SNAI1 protein]; SB 216763 inhibits the reaction [Asbestos, Serpentine affects the localization of SNAI1 protein]
Asbestos, Serpentine results in increased expression of SNAI1 protein

PMID:26685284 PMID:30609805

NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969

G

small nucleolar RNA, H/ACA box 12

increases expression

Asbestos, Serpentine results in increased expression of SNORA12 mRNA

NCBI chr 1:243,001,398...243,001,540
Ensembl chr 1:243,001,398...243,001,540

G

small nucleolar RNA, C/D box 13

increases expression

Asbestos, Serpentine results in increased expression of SNORD13 mRNA

NCBI chr16:60,988,909...60,989,013
Ensembl chr16:60,988,909...60,989,013

G

small nuclear ribonucleoprotein polypeptide F

increases methylation

Asbestos, Serpentine results in increased methylation of SNRPF 5' UTR

NCBI chr 7:28,130,427...28,137,129
Ensembl chr 7:28,130,427...28,137,129

G

SNW domain containing 1

increases expression

Asbestos, Serpentine results in increased expression of SNW1 mRNA

NCBI chr 6:107,095,450...107,119,536
Ensembl chr 6:107,095,457...107,119,536

G

sorting nexin 7

increases methylation

Asbestos, Serpentine results in increased methylation of SNX7 5' UTR

NCBI chr 2:205,843,164...205,927,737
Ensembl chr 2:205,842,837...205,927,763

G

sorting nexin 9

affects expression

Asbestos, Serpentine affects the expression of SNX9 mRNA

NCBI chr 1:46,424,897...46,510,096
Ensembl chr 1:46,423,553...46,509,036

G

superoxide dismutase 1

multiple interactions
increases expression

Dithiothreitol inhibits the reaction [SOD1 protein affects the reaction [Asbestos, Serpentine results in increased oxidation of STAT6 protein]]; SOD1 protein affects the reaction [Asbestos, Serpentine results in increased oxidation of STAT6 protein]
Asbestos, Serpentine results in increased expression of SOD1 protein

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

increases expression

Asbestos, Serpentine results in increased expression of SOD2 mRNA; Asbestos, Serpentine results in increased expression of SOD2 protein

PMID:7677184 PMID:8118652 PMID:23017228 PMID:24160326

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

superoxide dismutase 3

decreases expression

Asbestos, Serpentine results in decreased expression of SOD3 mRNA

NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990

G

sorbin and SH3 domain containing 1

increases methylation

Asbestos, Serpentine results in increased methylation of SORBS1 5' UTR

NCBI chr 1:239,107,882...239,330,276
Ensembl chr 1:239,108,777...239,330,169

G

SRY-box transcription factor 2

affects methylation

Asbestos, Serpentine affects the methylation of SOX2 exon

NCBI chr 2:117,536,929...117,539,340
Ensembl chr 2:117,536,929...117,539,338

G

SRY-box transcription factor 4

increases expression

Asbestos, Serpentine results in increased expression of SOX4 mRNA

NCBI chr17:35,667,809...35,672,515
Ensembl chr17:35,667,537...35,673,665

G

secreted protein acidic and cysteine rich

decreases expression

Asbestos, Serpentine results in decreased expression of SPARC mRNA

NCBI chr10:39,516,394...39,538,252
Ensembl chr10:39,516,406...39,538,396

G

sphingosine kinase 1

increases expression

Asbestos, Serpentine results in increased expression of SPHK1 mRNA

NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240

G

serine peptidase inhibitor Kazal type 13

decreases expression

Asbestos, Serpentine results in decreased expression of SPINK13 mRNA

NCBI chr18:56,064,839...56,206,257
Ensembl chr18:56,064,839...56,206,257

G

secreted phosphoprotein 1

increases expression
multiple interactions
decreases response to substance

Asbestos, Serpentine results in increased expression of SPP1 mRNA
SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in decreased expression of BPIFA1 mRNA]; SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in decreased expression of CYP2A4 mRNA]; SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in decreased expression of FMO3 mRNA]; SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in decreased expression of HAMP mRNA]; SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in decreased expression of HLF mRNA]; SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in decreased expression of MB mRNA]; SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in decreased expression of MYL7 mRNA]; SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in decreased expression of MYOZ2 mRNA]; SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in decreased expression of MYRIP mRNA]; SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in decreased expression of SULT1D1 mRNA]; SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in decreased expression of TCAP mRNA]; SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in decreased expression of THRSP mRNA]; SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in increased expression of ADAMTS2 mRNA]; SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in increased expression of AREG mRNA]; SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in increased expression of CCL3 protein]; SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in increased expression of CCL4 protein]; SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in increased expression of CKAP2 mRNA]; SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in increased expression of COL1A2 mRNA]; SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in increased expression of COL3A1 mRNA]; SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in increased expression of CXCL10 mRNA]; SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in increased expression of ELN mRNA]; SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in increased expression of IL12B protein]; SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in increased expression of IL1B protein]; SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in increased expression of IL4 protein]; SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in increased expression of IL6 protein]; SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in increased expression of NRCAM mRNA]; SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in increased expression of NUF2 mRNA]; SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in increased expression of PBK mRNA]; SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in increased expression of STBD1 mRNA]; SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in increased expression of THBS1 mRNA]; SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in increased expression of TIMP1 mRNA]; SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in increased expression of TNC mRNA]; SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in increased expression of TSP1 mRNA]; SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in increased expression of VCAN mRNA]; SPP1 gene mutant form promotes the reaction [Asbestos, Serpentine results in decreased expression of CCL11 protein]
SPP1 gene mutant form results in decreased susceptibility to Asbestos, Serpentine

PMID:16251409 PMID:21514415 PMID:23917077

NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162

G

small proline rich protein 2A

increases expression

Asbestos, Serpentine results in increased expression of SPRR2A mRNA

NCBI chr 2:177,815,964...177,816,236
Ensembl chr 2:177,815,964...177,816,236

G

SPT2 chromatin protein domain containing 1

increases expression

Asbestos, Serpentine results in increased expression of SPTY2D1 mRNA

NCBI chr 1:97,531,495...97,549,616
Ensembl chr 1:97,531,508...97,549,581

G

serglycin

increases expression

Asbestos, Serpentine results in increased expression of SRGN mRNA

NCBI chr20:30,442,810...30,479,549
Ensembl chr20:30,442,813...30,457,406

G

signal sequence receptor subunit 2

increases expression

Asbestos, Serpentine results in increased expression of SSR2 mRNA

NCBI chr 2:174,048,291...174,057,043
Ensembl chr 2:174,048,460...174,057,042

G

ST3 beta-galactoside alpha-2,3-sialyltransferase 5

decreases expression

Asbestos, Serpentine results in decreased expression of ST3GAL5 mRNA

NCBI chr 4:104,134,613...104,192,558
Ensembl chr 4:104,134,613...104,192,558

G

STAG3 cohesin complex component

decreases expression

Asbestos, Serpentine results in decreased expression of STAG3 mRNA

NCBI chr12:17,284,677...17,314,936
Ensembl chr12:17,284,794...17,314,935

G

Stam binding protein

increases expression

Asbestos, Serpentine results in increased expression of STAMBP mRNA

NCBI chr 4:116,055,563...116,083,563
Ensembl chr 4:116,056,057...116,080,543

G

StAR-related lipid transfer domain containing 13

increases expression

Asbestos, Serpentine results in increased expression of STARD13 mRNA

NCBI chr12:566,282...959,372
Ensembl chr12:566,310...959,421

G

signal transducer and activator of transcription 4

increases expression

Asbestos, Serpentine results in increased expression of STAT4 mRNA

NCBI chr 9:49,472,660...49,588,540
Ensembl chr 9:49,419,340...49,588,540

G

signal transducer and activator of transcription 6

multiple interactions
increases oxidation

Asbestos, Serpentine promotes the reaction [Polyethylene Glycols results in increased oxidation of STAT6 protein]; Asbestos, Serpentine promotes the reaction [STAT6 protein binds to KDM6B promoter]; Asbestos, Serpentine results in increased oxidation of and results in increased phosphorylation of STAT6 protein; Dithiothreitol inhibits the reaction [Asbestos, Serpentine promotes the reaction [polyethylene glycol-superoxide dismutase results in increased oxidation of STAT6 protein]]; Dithiothreitol inhibits the reaction [Asbestos, Serpentine promotes the reaction [Polyethylene Glycols results in increased oxidation of STAT6 protein]]; Dithiothreitol inhibits the reaction [Asbestos, Serpentine results in increased oxidation of STAT6 protein]; Dithiothreitol inhibits the reaction [SOD1 protein affects the reaction [Asbestos, Serpentine results in increased oxidation of STAT6 protein]]; leflunomide inhibits the reaction [Asbestos, Serpentine results in increased phosphorylation of STAT6 protein]; polyethylene glycol-superoxide dismutase affects the reaction [STAT6 protein affects the reaction [Asbestos, Serpentine affects the expression of TNF mRNA]]; SOD1 protein affects the reaction [Asbestos, Serpentine results in increased oxidation of STAT6 protein]; STAT6 protein affects the reaction [Asbestos, Serpentine affects the expression of CHIL3 mRNA]; STAT6 protein affects the reaction [Asbestos, Serpentine affects the expression of CHIL3 protein]; STAT6 protein affects the reaction [Asbestos, Serpentine affects the expression of KDM6B mRNA]; STAT6 protein affects the reaction [Asbestos, Serpentine affects the expression of RETNLA mRNA]; STAT6 protein affects the reaction [Asbestos, Serpentine affects the expression of TGFB1 protein]; STAT6 protein affects the reaction [Asbestos, Serpentine affects the expression of TNF mRNA]; STAT6 protein affects the reaction [Asbestos, Serpentine affects the expression of TNF protein]

NCBI chr 7:63,480,229...63,497,551
Ensembl chr 7:63,479,642...63,498,495

G

starch binding domain 1

multiple interactions
increases expression

SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in increased expression of STBD1 mRNA]

NCBI chr14:15,470,452...15,473,857
Ensembl chr14:15,469,582...15,477,443

G

stanniocalcin 2

increases expression

Asbestos, Serpentine results in increased expression of STC2 mRNA

NCBI chr10:16,251,046...16,260,815
Ensembl chr10:16,250,853...16,262,973

G

STEAP4 metalloreductase

decreases expression
increases expression

Asbestos, Serpentine results in decreased expression of STEAP4 mRNA
Asbestos, Serpentine results in increased expression of STEAP4 mRNA

NCBI chr 4:26,077,182...26,099,859
Ensembl chr 4:26,054,671...26,099,859

G

serine/threonine kinase 24

increases methylation

Asbestos, Serpentine results in increased methylation of STK24 gene

NCBI chr15:98,363,707...98,458,940
Ensembl chr15:98,365,791...98,460,553

G

serine/threonine kinase 32C

increases methylation

Asbestos, Serpentine results in increased methylation of STK32C gene

NCBI chr 1:193,900,718...193,981,723
Ensembl chr 1:193,900,718...193,981,723

G

stomatin

decreases expression

Asbestos, Serpentine results in decreased expression of STOM mRNA

NCBI chr 3:18,645,058...18,667,343
Ensembl chr 3:18,644,378...18,667,354

G

serine/threonine/tyrosine kinase 1

increases expression

Asbestos, Serpentine results in increased expression of STYK1 mRNA

NCBI chr 4:165,047,613...165,097,890
Ensembl chr 4:165,048,440...165,096,440

G

SUN domain containing ossification factor

decreases methylation

Asbestos, Serpentine results in decreased methylation of SUCO 5' UTR

NCBI chr13:74,192,808...74,257,896
Ensembl chr13:74,193,573...74,257,896

G

sulfatase 2

decreases expression

Asbestos, Serpentine results in decreased expression of SULF2 mRNA

NCBI chr 3:154,822,079...154,904,566
Ensembl chr 3:154,822,085...154,904,415

G

sushi domain containing 6

affects expression

Asbestos, Serpentine affects the expression of SUSD6 mRNA

NCBI chr 6:100,437,834...100,531,621
Ensembl chr 6:100,437,642...100,531,606

G

syncoilin, intermediate filament protein

decreases methylation

Asbestos, Serpentine results in decreased methylation of SYNC 5' UTR

NCBI chr 5:141,631,837...141,656,184
Ensembl chr 5:141,632,367...141,688,659

G

T-box brain transcription factor 1

decreases methylation

Asbestos, Serpentine results in decreased methylation of TBR1 promoter

NCBI chr 3:46,350,237...46,368,397
Ensembl chr 3:46,351,213...46,361,041

G

T-box transcription factor 4

decreases methylation

Asbestos, Serpentine results in decreased methylation of TBX4 promoter

NCBI chr10:70,730,686...70,760,829
Ensembl chr10:70,731,163...70,760,825

G

titin-cap

multiple interactions
decreases expression

SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in decreased expression of TCAP mRNA]

NCBI chr10:83,381,719...83,382,887
Ensembl chr10:83,381,719...83,382,887

G

transcription elongation factor A N-terminal and central domain containing 2

affects methylation

Asbestos, Serpentine affects the methylation of TCEANC2 5' UTR

NCBI chr 5:121,923,959...121,963,018
Ensembl chr 5:121,923,956...121,962,183

G

telomerase reverse transcriptase

increases response to substance

TERT protein results in increased susceptibility to Asbestos, Serpentine

NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561

G

testis expressed gene 19.2

increases expression

Asbestos, Serpentine results in increased expression of TEX19 mRNA

NCBI chr10:106,379,757...106,382,344
Ensembl chr10:106,379,757...106,382,344

G

tissue factor pathway inhibitor 2

increases expression

Asbestos, Serpentine results in increased expression of TFPI2 mRNA

NCBI chr 4:31,981,786...31,986,707
Ensembl chr 4:31,982,178...31,986,600

G

transforming growth factor alpha

multiple interactions
increases expression

[TNFRSF1A gene mutant form co-treated with TNFRSF1B gene mutant form] inhibits the reaction [Asbestos, Serpentine results in increased expression of TGFA mRNA]
Asbestos, Serpentine results in increased expression of TGFA mRNA; Asbestos, Serpentine results in increased expression of TGFA protein

PMID:8686744 PMID:9846974

NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894

G

transforming growth factor, beta 1

multiple interactions
increases secretion
increases expression
increases activity
affects expression

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Asbestos, Serpentine results in increased secretion of TGFB1 protein]; pyrazolanthrone inhibits the reaction [Asbestos, Serpentine results in increased secretion of TGFB1 protein]; SB 203580 inhibits the reaction [Asbestos, Serpentine results in increased secretion of TGFB1 protein]; TGFB1 protein affects the reaction [Asbestos, Serpentine results in decreased expression of CDH1 protein]; TGFB1 protein affects the reaction [Asbestos, Serpentine results in decreased expression of CTNNB1 protein]; TGFB1 protein affects the reaction [Asbestos, Serpentine results in increased expression of ACTA2 protein]; TGFB1 protein affects the reaction [Asbestos, Serpentine results in increased expression of FN1 protein]; TGFB1 protein affects the reaction [Asbestos, Serpentine results in increased expression of VIM protein]
Asbestos, Serpentine results in increased expression of TGFB1 protein
Asbestos, Serpentine promotes the reaction [TNF protein results in increased expression of TGFB1 mRNA]; STAT6 protein affects the reaction [Asbestos, Serpentine affects the expression of TGFB1 protein]; TGFB1 protein affects the reaction [Asbestos, Serpentine results in increased expression of CCN2]
Asbestos, Serpentine results in increased activity of TGFB1 protein
Asbestos, Serpentine results in increased expression of TGFB1; Asbestos, Serpentine results in increased expression of TGFB1 mRNA; Asbestos, Serpentine results in increased expression of TGFB1 protein

PMID:18039278 PMID:18569384 PMID:19105532 PMID:19817698 PMID:25324550 More...

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

transforming growth factor, beta receptor 2

multiple interactions

[Asbestos, Serpentine results in decreased susceptibility to Asbestos] which results in decreased expression of TGFBR2 mRNA

NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228

G

TGFB-induced factor homeobox 1

increases methylation

Asbestos, Serpentine results in increased methylation of TGIF1 5' UTR

NCBI chr 9:110,748,094...110,757,714
Ensembl chr 9:110,720,921...110,757,802

G

thrombomodulin

decreases expression

Asbestos, Serpentine results in decreased expression of THBD mRNA

NCBI chr 3:135,863,366...135,867,018
Ensembl chr 3:135,862,835...135,867,193

G

thrombospondin 1

increases expression
multiple interactions

Asbestos, Serpentine results in increased expression of THBS1 mRNA
SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in increased expression of THBS1 mRNA]

NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440

G

thrombospondin 2

increases expression

Asbestos, Serpentine results in increased expression of THBS2 mRNA

NCBI chr 1:55,670,394...55,699,789
Ensembl chr 1:55,670,394...55,699,789

G

thyroid hormone responsive

decreases expression
multiple interactions

Asbestos, Serpentine results in decreased expression of THRSP mRNA
SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in decreased expression of THRSP mRNA]

NCBI chr 1:151,723,415...151,727,740
Ensembl chr 1:151,723,086...151,728,075

G

TIAM Rac1 associated GEF 2

decreases methylation

Asbestos, Serpentine results in decreased methylation of TIAM2 promoter

NCBI chr 1:43,918,179...44,119,499
Ensembl chr 1:43,918,174...44,119,493

G

TIMP metallopeptidase inhibitor 1

increases expression
multiple interactions

Asbestos, Serpentine results in increased expression of TIMP1 mRNA
SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in increased expression of TIMP1 mRNA]; U 0126 inhibits the reaction [Asbestos, Serpentine results in increased expression of TIMP1 mRNA]

PMID:16571779 PMID:21514415

NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664

G

TIMP metallopeptidase inhibitor 3

decreases expression
increases expression

Asbestos, Serpentine results in decreased expression of TIMP3 mRNA
Asbestos, Serpentine results in increased expression of TIMP3 mRNA

NCBI chr 7:17,520,827...17,571,850
Ensembl chr 7:17,521,919...17,571,839

G

tubulointerstitial nephritis antigen-like 1

decreases expression

Asbestos, Serpentine results in decreased expression of TINAGL1 mRNA

NCBI chr 5:142,513,710...142,523,730
Ensembl chr 5:142,513,714...142,523,720

G

TERF1 interacting nuclear factor 2

decreases expression

Asbestos, Serpentine results in decreased expression of TINF2 mRNA

NCBI chr15:29,170,663...29,178,015
Ensembl chr15:29,170,652...29,176,984

G

tight junction protein 1

increases expression

Asbestos, Serpentine results in increased expression of TJP1 mRNA

NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432

G

TLC domain containing 4

increases expression

Asbestos, Serpentine results in increased expression of TLCD4 mRNA

NCBI chr 2:209,284,873...209,360,156
Ensembl chr 2:209,289,732...209,341,353

G

toll-like receptor 3

increases expression

Asbestos, Serpentine results in increased expression of TLR3 mRNA

NCBI chr16:46,821,980...46,837,900
Ensembl chr16:46,822,039...46,836,545

G

T-cell leukemia homeobox 2

decreases methylation

Asbestos, Serpentine results in decreased methylation of TLX2 promoter

NCBI chr 4:115,573,736...115,576,097
Ensembl chr 4:115,573,799...115,575,642

G

transmembrane and coiled-coil domain family 2

decreases expression

Asbestos, Serpentine results in decreased expression of TMCC2 mRNA

NCBI chr13:43,794,029...43,831,716
Ensembl chr13:43,794,029...43,831,716

G

transmembrane protein 106A

decreases expression

Asbestos, Serpentine results in decreased expression of TMEM106A mRNA

NCBI chr10:86,506,908...86,515,915
Ensembl chr10:86,506,936...86,515,892

G

transmembrane protein 132D

decreases methylation

Asbestos, Serpentine results in decreased methylation of TMEM132D gene

NCBI chr12:28,270,039...28,917,324
Ensembl chr12:28,270,712...28,915,374

G

transmembrane protein 158

increases expression

Asbestos, Serpentine results in increased expression of TMEM158 mRNA

NCBI chr 8:122,913,675...122,914,673
Ensembl chr 8:122,913,675...122,914,673

G

transmembrane protein 59

affects methylation

Asbestos, Serpentine affects the methylation of TMEM59 gene

NCBI chr 5:121,962,507...121,983,625
Ensembl chr 5:121,962,440...121,983,625

G

transmembrane serine protease 11D

decreases methylation

Asbestos, Serpentine results in decreased methylation of TMPRSS11D gene

NCBI chr14:21,707,336...21,769,398
Ensembl chr14:21,707,336...21,769,396

G

transmembrane serine protease 15

affects expression

Asbestos, Serpentine affects the expression of TMPRSS15 mRNA

NCBI chr11:17,677,741...17,802,255
Ensembl chr11:17,677,741...17,802,255

G

transmembrane serine protease 3

increases expression

Asbestos, Serpentine results in increased expression of TMPRSS3 mRNA

NCBI chr20:9,254,102...9,273,808
Ensembl chr20:9,254,109...9,274,363