amino-acid ester - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	amino-acid ester	go back to main search page
Accession:	CHEBI:46668	browse the term
Definition:	Any carboxylic ester derivative of an amino acid.
Synonyms:	related_synonym:	amino acid esters

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Genes (429)

2-[2-(diethylamino)ethylamino]-2-phenylacetic acid 3-methylbutyl ester

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

potassium voltage-gated channel subfamily H member 2

decreases activity

camylofine results in decreased activity of KCNH2 protein

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

aspartame

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 1

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ABCA1 mRNA

NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170

G

ATP binding cassette subfamily B member 4

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ABCB4 mRNA

NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202

G

ATP binding cassette subfamily D member 1

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of ABCD1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ABCD1 mRNA

NCBI chr X:151,428,334...151,450,115
Ensembl chr X:151,428,578...151,450,115

G

ATP binding cassette subfamily D member 2

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ABCD2 mRNA

NCBI chr 7:122,263,034...122,311,642
Ensembl chr 7:122,263,032...122,311,642

G

acetyl-CoA acyltransferase 1A

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of ACAA1A mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ACAA1A mRNA

NCBI chr 8:119,079,401...119,088,626
Ensembl chr 8:119,079,775...119,088,624

G

acetyl-Coenzyme A acyltransferase 1B

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ACAA1B mRNA

NCBI chr 8:118,872,996...118,881,852
Ensembl chr 8:118,872,997...118,881,825

G

acetyl-CoA carboxylase beta

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ACACB mRNA

NCBI chr12:42,365,800...42,477,651
Ensembl chr12:42,366,548...42,457,655

G

acyl-CoA dehydrogenase short chain

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of ACADS mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ACADS mRNA

NCBI chr12:41,493,650...41,502,897
Ensembl chr12:41,493,626...41,502,898

G

acyl-CoA dehydrogenase, very long chain

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of ACADVL mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ACADVL mRNA

NCBI chr10:54,732,875...54,738,102
Ensembl chr10:54,732,469...54,738,075

G

acetylcholinesterase

decreases activity

Aspartame metabolite results in decreased activity of ACHE protein

PMID:16129618 PMID:17580119 PMID:17673349

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

aconitase 1

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of ACO1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ACO1 mRNA

NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391

G

acyl-CoA thioesterase 1

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ACOT1 mRNA

NCBI chr 6:103,636,173...103,644,167
Ensembl chr 6:103,636,041...103,644,163

G

adhesion G protein-coupled receptor E1

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ADGRE1 mRNA

NCBI chr 9:2,242,476...2,398,000
Ensembl chr 9:2,242,474...2,398,000

G

angiotensinogen

decreases expression

Aspartame results in decreased expression of AGT mRNA

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

angiotensin II receptor, type 1a

decreases expression

Aspartame results in decreased expression of AGTR1 mRNA

NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946

G

AKT serine/threonine kinase 1

increases phosphorylation

Aspartame results in increased phosphorylation of AKT1 protein

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

arachidonate 15-lipoxygenase

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ALOX15 mRNA

NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874

G

apolipoprotein E

decreases expression

Aspartame results in decreased expression of APOE mRNA

NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

[Aspartame co-treated with Methotrexate] results in increased expression of BAX mRNA; [Aspartame co-treated with Methotrexate] results in increased expression of BAX protein
Aspartame results in increased expression of BAX mRNA
[Fats, Unsaturated co-treated with Aspartame] affects the expression of BAX mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of BAX mRNA

PMID:23783067 PMID:25009784 PMID:32951320

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions
decreases expression

[Aspartame co-treated with Methotrexate] results in decreased expression of BCL2 mRNA; [Aspartame co-treated with Methotrexate] results in decreased expression of BCL2 protein
Aspartame results in decreased expression of BCL2 mRNA

PMID:25009784 PMID:32951320

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

calcium binding protein 2

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of CABP2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CABP2 mRNA

NCBI chr 1:201,374,649...201,380,469
Ensembl chr 1:201,375,276...201,380,469

G

calcium voltage-gated channel subunit alpha1 A

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of CACNA1A mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CACNA1A mRNA

NCBI chr19:23,520,741...23,819,971
Ensembl chr19:23,520,741...23,823,225

G

calcium voltage-gated channel subunit alpha1 I

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of CACNA1I mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CACNA1I mRNA

NCBI chr 7:111,835,996...111,947,418
Ensembl chr 7:111,836,012...111,944,688

G

calcium voltage-gated channel auxiliary subunit alpha2delta 4

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of CACNA2D4 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CACNA2D4 mRNA

NCBI chr 4:152,408,588...152,521,478
Ensembl chr 4:152,408,657...152,521,268

G

calcium voltage-gated channel auxiliary subunit beta 2

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of CACNB2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CACNB2 mRNA

NCBI chr17:77,564,630...77,910,000
Ensembl chr17:77,564,460...77,909,106

G

calcium voltage-gated channel auxiliary subunit gamma 4

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of CACNG4 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CACNG4 mRNA

NCBI chr10:92,683,778...92,745,842
Ensembl chr10:92,683,761...92,746,126

G

calcium voltage-gated channel auxiliary subunit gamma 8

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of CACNG8 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CACNG8 mRNA

NCBI chr 1:65,755,334...65,775,567
Ensembl chr 1:65,755,334...65,779,089

G

calcium homeostasis modulator family member 2

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of CALHM2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CALHM2 mRNA

NCBI chr 1:246,022,324...246,028,050
Ensembl chr 1:246,022,324...246,028,218

G

calreticulin 3

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of CALR3 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CALR3 mRNA

NCBI chr16:17,396,064...17,423,166
Ensembl chr16:17,396,247...17,423,015

G

calcium activated nucleotidase 1

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of CANT1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CANT1 mRNA

NCBI chr10:103,637,079...103,650,240
Ensembl chr10:103,531,504...103,650,109

G

caspase 3

multiple interactions
increases expression

[Aspartame co-treated with Methotrexate] results in increased expression of CASP3 mRNA; [Aspartame co-treated with Methotrexate] results in increased expression of CASP3 protein modified form
Aspartame results in increased expression of CASP3 mRNA

PMID:25009784 PMID:32951320

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 9

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of CASP9 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CASP9 mRNA

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

multiple interactions
decreases activity

[Aspartame co-treated with Methotrexate] results in increased activity of CAT protein
Aspartame results in decreased activity of CAT protein

PMID:25009784 PMID:32951320

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 2

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] results in increased expression of CCL2 protein; [Sodium Glutamate co-treated with Aspartame] inhibits the reaction [Fats, Unsaturated results in increased expression of CCL2 protein]

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

cadherin 1

decreases expression

Aspartame results in decreased expression of CDH1 protein

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

cyclin-dependent kinase inhibitor 1A

affects localization
multiple interactions

Aspartame affects the localization of CDKN1A protein
TAS1R1 protein affects the reaction [Aspartame affects the localization of CDKN1A protein]

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 1B

multiple interactions
decreases expression

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CDKN1B mRNA
Aspartame results in decreased expression of CDKN1B protein

PMID:23783067 PMID:33992720

NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982

G

calcium homeostasis endoplasmic reticulum protein

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of CHERP mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CHERP mRNA

NCBI chr16:17,367,455...17,380,507
Ensembl chr16:17,367,455...17,380,507

G

C-x(9)-C motif containing 1

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of CMC1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CMC1 mRNA

NCBI chr 8:117,798,036...117,900,458
Ensembl chr 8:117,798,945...117,900,462

G

cytochrome c oxidase copper chaperone COX11

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of COX11 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of COX11 mRNA

NCBI chr10:75,458,735...75,465,322
Ensembl chr10:75,458,749...75,465,322

G

cytochrome c oxidase subunit 7A1

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of COX7A1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of COX7A1 mRNA

NCBI chr 1:85,422,162...85,447,530
Ensembl chr 1:85,441,871...85,445,151

G

carnitine palmitoyltransferase 1B

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of CPT1B mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CPT1B mRNA

NCBI chr 7:120,491,354...120,500,833
Ensembl chr 7:120,491,354...120,500,404

G

carnitine palmitoyltransferase 1c

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CPT1C mRNA

NCBI chr 1:95,442,814...95,457,347
Ensembl chr 1:95,442,817...95,457,342

G

cAMP responsive element binding protein 1

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CREB1 mRNA

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

G

colony stimulating factor 1

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CSF1 mRNA

NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases activity

Aspartame results in increased activity of CYP1A1 protein

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

increases activity

Aspartame results in increased activity of CYP1A2 protein

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 2, subfamily b, polypeptide 1

multiple interactions

Aspartame results in increased expression of and results in increased activity of CYP2B1 protein

NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052

G

cytochrome P450, family 2, subfamily b, polypeptide 2

increases activity

Aspartame results in increased activity of CYP2B2 protein

NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions

Aspartame results in increased expression of and results in increased activity of CYP2E1 protein

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 3, subfamily a, polypeptide 62

increases activity

Aspartame results in increased activity of CYP3A62 protein

NCBI chr12:16,397,998...16,433,833
Ensembl chr12:16,397,998...16,433,833

G

diablo, IAP-binding mitochondrial protein

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of DIABLO mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of DIABLO mRNA

NCBI chr12:33,055,784...33,070,401
Ensembl chr12:33,055,263...33,070,387

G

DnaJ heat shock protein family (Hsp40) member C27

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of DNAJC27 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of DNAJC27 mRNA

NCBI chr 6:27,068,713...27,098,449
Ensembl chr 6:27,068,686...27,098,449

G

E2F transcription factor 1

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of E2F1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of E2F1 mRNA

NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361

G

endothelin 2

decreases expression

Aspartame results in decreased expression of EDN2 mRNA

NCBI chr 5:133,751,316...133,756,814
Ensembl chr 5:133,751,217...133,756,814

G

endothelin receptor type A

decreases expression

Aspartame results in decreased expression of EDNRA mRNA

NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049

G

enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of EHHADH mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of EHHADH mRNA

NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188

G

epoxide hydrolase 2

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of EPHX2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of EPHX2 mRNA

NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615

G

coagulation factor II, thrombin

decreases activity

Aspartame analog results in decreased activity of F2 protein; Aspartame results in decreased activity of F2 protein

NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486

G

fibroblast growth factor 1

increases expression

Aspartame results in increased expression of FGF1 mRNA

NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357

G

forkhead box O3

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of FOXO3 mRNA

NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561

G

follicle stimulating hormone subunit beta

decreases expression

Aspartame results in decreased expression of FSHB protein

NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370

G

growth arrest and DNA-damage-inducible, beta

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of GADD45B mRNA

NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046

G

GTP dependent ribosome recycling factor mitochondrial 2

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of GFM2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of GFM2 mRNA

NCBI chr 2:28,449,452...28,488,200
Ensembl chr 2:28,449,517...28,488,197

G

gastric inhibitory polypeptide

multiple interactions

Aspartame promotes the reaction [Fats, Unsaturated results in increased expression of GIP protein]; Sodium Glutamate inhibits the reaction [Aspartame promotes the reaction [Fats, Unsaturated results in increased expression of GIP protein]]

NCBI chr10:80,968,360...80,976,506
Ensembl chr10:80,968,352...80,976,503

G

GLI family zinc finger 1

affects localization
multiple interactions

Aspartame affects the localization of GLI1 protein
TAS1R1 protein affects the reaction [Aspartame affects the localization of GLI1 protein]

NCBI chr 7:63,156,926...63,169,579
Ensembl chr 7:63,156,926...63,169,251

G

GLI family zinc finger 2

decreases expression

Aspartame results in decreased expression of GLI2 protein

NCBI chr13:29,946,882...30,163,589
Ensembl chr13:29,946,809...30,163,574

G

glycogen synthase kinase 3 beta

increases phosphorylation

Aspartame results in increased phosphorylation of GSK3B protein

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

glutathione-disulfide reductase

multiple interactions

[Aspartame co-treated with Methotrexate] results in decreased activity of GSR protein

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of HADHA mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of HADHA mRNA

NCBI chr 6:26,187,969...26,227,605
Ensembl chr 6:26,187,956...26,227,869

G

hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of HADHB mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of HADHB mRNA

NCBI chr 6:26,153,572...26,187,668
Ensembl chr 6:26,153,578...26,184,869

G

histone deacetylase 1

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of HDAC1 mRNA

NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111

G

histone deacetylase 5

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of HDAC5 mRNA

NCBI chr10:87,152,978...87,187,921
Ensembl chr10:87,152,978...87,188,235

G

hepatocyte growth factor

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of HGF mRNA

NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409

G

HRas proto-oncogene, GTPase

increases expression

Aspartame results in increased expression of HRAS

NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615

G

heparan sulfate proteoglycan 2

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of HSPG2 mRNA

NCBI chr 5:149,677,437...149,778,594
Ensembl chr 5:149,677,476...149,778,594

G

isocitrate dehydrogenase (NADP(+)) 2

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of IDH2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of IDH2 mRNA

NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025

G

interleukin 11

decreases expression

Aspartame results in decreased expression of IL11 mRNA

NCBI chr 1:69,069,829...69,076,129
Ensembl chr 1:69,068,137...69,076,129

G

interleukin 1 beta

increases expression

Aspartame results in increased expression of IL1B mRNA

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 3

decreases expression

Aspartame results in decreased expression of IL3 mRNA

NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066

G

interleukin 6

increases secretion

Aspartame results in increased secretion of IL6 protein

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

inner membrane mitochondrial protein

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of IMMT mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of IMMT mRNA

NCBI chr 4:103,880,482...103,919,116
Ensembl chr 4:103,880,459...103,919,109

G

insulin 2

increases expression
multiple interactions

Aspartame results in increased expression of INS protein
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] results in increased expression of INS2 protein; Aspartame inhibits the reaction [Fats, Unsaturated results in increased expression of INS2 protein]

PMID:1805284 PMID:23783067

NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775

G

kinase insert domain receptor

increases secretion

Aspartame results in increased secretion of KDR protein

NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018

G

leptin

decreases expression
multiple interactions

Aspartame results in decreased expression of LEP protein
[Fats, Unsaturated co-treated with Aspartame] results in increased expression of LEP protein; [Sodium Glutamate co-treated with Aspartame] promotes the reaction [Fats, Unsaturated results in increased expression of LEP protein]

PMID:11890951 PMID:23783067

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

G

luteinizing hormone subunit beta

decreases expression

Aspartame results in decreased expression of LHB protein

NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972

G

lipase G, endothelial type

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of LIPG mRNA

NCBI chr18:68,514,923...68,536,105
Ensembl chr18:68,514,923...68,536,260

G

LDL receptor related protein 1

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of LRP1 mRNA

NCBI chr 7:63,380,325...63,461,029
Ensembl chr 7:63,380,356...63,460,910

G

LDL receptor related protein 2

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of LRP2 mRNA

NCBI chr 3:54,189,305...54,346,769
Ensembl chr 3:54,189,308...54,346,708

G

LDL receptor related protein 4

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of LRP4 mRNA

NCBI chr 3:77,429,600...77,483,593
Ensembl chr 3:77,429,798...77,483,593

G

mitogen activated protein kinase 1

increases phosphorylation

Aspartame results in increased phosphorylation of MAPK1 protein

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

increases phosphorylation

Aspartame results in increased phosphorylation of MAPK3 protein

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitochondrial calcium uniporter

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of MCU mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MCU mRNA

NCBI chr20:27,417,529...27,580,110
Ensembl chr20:27,417,526...27,580,110

G

MDM2 proto-oncogene

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MDM2 mRNA

NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915

G

mediator complex subunit 23

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MED23 mRNA

NCBI chr 1:20,490,315...20,558,461
Ensembl chr 1:20,490,315...20,537,463

G

myocyte enhancer factor 2D

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MEF2D mRNA

NCBI chr 2:173,606,054...173,635,620
Ensembl chr 2:173,606,490...173,634,457

G

mitochondrial contact site and cristae organizing system subunit 10

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of MINOS1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MINOS1 mRNA

NCBI chr 5:151,341,124...151,367,403
Ensembl chr 5:151,339,176...151,367,485

G

mitochondrial calcium uptake 1

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of MICU1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MICU1 mRNA

NCBI chr20:27,668,681...27,816,322
Ensembl chr20:27,668,747...27,814,964

G

mitochondrial ribosomal protein L20

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of MRPL20 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MRPL20 mRNA

NCBI chr 5:166,408,962...166,413,492
Ensembl chr 5:166,408,962...166,413,492

G

mitochondrial ribosomal protein L3

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of MRPL3 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MRPL3 mRNA

NCBI chr 8:105,670,184...105,693,544
Ensembl chr 8:105,670,184...105,693,544

G

mitochondrial ribosomal protein S12

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of MRPS12 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MRPS12 mRNA

NCBI chr 1:84,025,896...84,028,896
Ensembl chr 1:84,025,899...84,028,780

G

mitochondrial ribosomal protein S24

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of MRPS24 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MRPS24 mRNA

NCBI chr14:80,584,671...80,588,801
Ensembl chr14:80,584,673...80,588,871

G

mitochondrial ribosomal protein S27

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of MRPS27 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MRPS27 mRNA

NCBI chr 2:30,740,007...30,808,577
Ensembl chr 2:30,740,033...30,808,577

G

mitochondrial ribosomal protein S7

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of MRPS7 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MRPS7 mRNA

NCBI chr10:100,843,691...100,846,838
Ensembl chr10:100,843,356...100,847,129

G

mitochondrial fission process 1

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of MTFP1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MTFP1 mRNA

NCBI chr14:78,968,434...78,972,274
Ensembl chr14:78,968,442...78,972,274

G

MYC proto-oncogene, bHLH transcription factor

increases expression

Aspartame results in increased expression of MYC
Aspartame results in increased expression of MYC protein

PMID:17354619 PMID:33992720

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

nuclear receptor co-repressor 1

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NCOR1 mRNA

NCBI chr10:46,999,536...47,142,294
Ensembl chr10:46,999,536...47,141,032

G

NADH:ubiquinone oxidoreductase subunit A12

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFA12 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFA12 mRNA

NCBI chr 7:28,771,330...28,798,316
Ensembl chr 7:28,771,330...28,798,315

G

NADH:ubiquinone oxidoreductase subunit A5

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFA5 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFA5 mRNA

NCBI chr 4:52,997,327...53,005,685
Ensembl chr 4:52,995,546...53,005,598
Ensembl chr 5:52,995,546...53,005,598

G

NADH:ubiquinone oxidoreductase subunit B10

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFB10 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFB10 mRNA

NCBI chr10:13,749,273...13,751,434
Ensembl chr10:13,749,275...13,751,442

G

NADH:ubiquinone oxidoreductase subunit B2

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFB2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFB2 mRNA

NCBI chr 4:68,367,526...68,374,609
Ensembl chr15:46,536,062...46,536,851
Ensembl chr 4:46,536,062...46,536,851

G

NADH:ubiquinone oxidoreductase subunit B6

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFB6 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFB6 mRNA

NCBI chr 5:55,400,543...55,410,110
Ensembl chr 5:55,400,543...55,410,181

G

NADH:ubiquinone oxidoreductase core subunit S1

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFS1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFS1 mRNA

NCBI chr 9:64,546,430...64,579,751
Ensembl chr 9:64,546,225...64,579,893

G

NADH:ubiquinone oxidoreductase subunit S6

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFS6 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFS6 mRNA

NCBI chr 1:29,968,833...29,977,423
Ensembl chr 1:29,968,842...29,977,467

G

NADH:ubiquinone oxidoreductase core subunit V1

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFV1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFV1 mRNA

NCBI chr 1:201,300,365...201,305,461
Ensembl chr 1:201,299,985...201,305,466

G

neurofibromin 1

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NF1 mRNA

NCBI chr10:64,306,027...64,539,112
Ensembl chr10:64,306,301...64,536,658

G

notch receptor 1

multiple interactions
affects localization

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NOTCH1 mRNA
Aspartame affects the localization of NOTCH1 protein modified form
TAS1R1 protein affects the reaction [Aspartame affects the localization of NOTCH1 protein modified form]

PMID:23783067 PMID:33992720

NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531

G

NADPH oxidase 1

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NOX1 mRNA

NCBI chr X:97,279,058...97,332,291
Ensembl chr X:97,279,056...97,302,236

G

natriuretic peptide B

decreases expression

Aspartame results in decreased expression of NPPB mRNA

NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168

G

neuropeptide Y

decreases expression

Aspartame results in decreased expression of NPY protein

NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495

G

nuclear receptor subfamily 1, group I, member 3

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NR1I3 mRNA

NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906

G

one cut homeobox 1

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ONECUT1 mRNA

NCBI chr 8:75,599,432...75,633,598
Ensembl chr 8:75,599,740...75,627,277

G

pyruvate dehydrogenase E1 subunit alpha 2

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of PDHA2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PDHA2 mRNA

NCBI chr 2:229,872,300...229,873,848

G

pyruvate dehydrogenase E1 subunit beta

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of PDHB mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PDHB mRNA

NCBI chr15:16,752,561...16,758,503
Ensembl chr15:16,750,980...16,758,500

G

peroxisomal biogenesis factor 1

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of PEX1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PEX1 mRNA

NCBI chr 4:30,519,950...30,558,953
Ensembl chr 4:30,519,955...30,558,921

G

peroxisomal biogenesis factor 11 alpha

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of PEX11A mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PEX11A mRNA

NCBI chr 1:133,680,091...133,687,172
Ensembl chr 1:133,680,091...133,687,172

G

peroxisomal biogenesis factor 13

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of PEX13 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PEX13 mRNA

NCBI chr14:97,602,829...97,621,233
Ensembl chr14:97,603,539...97,621,262

G

peroxisomal biogenesis factor 5

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of PEX5 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PEX5 mRNA

NCBI chr 4:157,270,671...157,296,432
Ensembl chr 4:157,270,672...157,296,431

G

peroxisomal biogenesis factor 7

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of PEX7 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PEX7 mRNA

NCBI chr 1:14,582,698...14,646,686
Ensembl chr 1:14,582,699...14,646,748

G

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of PFKFB2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PFKFB2 mRNA

NCBI chr13:42,147,473...42,174,699
Ensembl chr13:42,147,478...42,174,699

G

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of PFKFB4 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PFKFB4 mRNA

NCBI chr 8:109,643,558...109,687,006
Ensembl chr 8:109,643,937...109,685,634

G

phospholipase D2

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PLD2 mRNA

NCBI chr10:55,256,326...55,274,192
Ensembl chr10:55,256,359...55,272,808

G

plasminogen

decreases expression

Aspartame results in decreased expression of PLG mRNA

NCBI chr 1:48,325,186...48,367,643
Ensembl chr 1:48,325,185...48,367,786

G

plexin D1

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PLXND1 mRNA

NCBI chr 4:149,002,786...149,043,097
Ensembl chr 4:149,002,784...149,043,244

G

DNA polymerase gamma, catalytic subunit

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of POLG mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of POLG mRNA

NCBI chr 1:133,382,764...133,399,578
Ensembl chr 1:133,382,766...133,398,567

G

proopiomelanocortin

increases expression

Aspartame results in increased expression of POMC protein alternative form

NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664

G

POU class 5 homeobox 1

affects localization

Aspartame affects the localization of POU5F1 protein

NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891

G

peroxisome proliferator activated receptor alpha

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of PPARA mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PPARA mRNA

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

peroxisome proliferator-activated receptor delta

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PPARD mRNA

NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968

G

peroxisome proliferator-activated receptor gamma

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PPARG mRNA

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

PPARG coactivator 1 alpha

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of PPARGC1A mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PPARGC1A mRNA

NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656

G

peroxiredoxin 5

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of PRDX5 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PRDX5 mRNA

NCBI chr 1:204,099,826...204,103,589
Ensembl chr 1:204,099,826...204,114,268

G

Rho-associated coiled-coil containing protein kinase 1

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ROCK1 mRNA

NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571

G

S100 calcium binding protein A13

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of S100A13 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of S100A13 mRNA

NCBI chr 2:175,999,439...176,005,933

G

S100 calcium binding protein A8

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of S100A8 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of S100A8 mRNA

NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643

G

succinate dehydrogenase complex iron sulfur subunit B

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of SDHB mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SDHB mRNA

NCBI chr 5:153,264,906...153,285,570
Ensembl chr 5:153,264,899...153,314,293

G

sirtuin 1

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SIRT1 mRNA

NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260

G

sirtuin 2

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SIRT2 mRNA

NCBI chr 1:84,053,883...84,076,975
Ensembl chr 1:84,052,903...84,076,975

G

solute carrier family 15 member 1

decreases activity

Aspartame results in decreased activity of SLC15A1 protein

NCBI chr15:98,537,641...98,582,544
Ensembl chr15:98,537,641...98,582,545

G

solute carrier family 4 member 2

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SLC4A2 mRNA

NCBI chr 4:10,736,419...10,754,407
Ensembl chr 4:10,736,425...10,752,965

G

solute carrier family 8 member A1

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of SLC8A1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SLC8A1 mRNA

NCBI chr 6:13,194,609...13,547,369
Ensembl chr 6:13,194,662...13,535,628

G

SRY-box transcription factor 2

affects localization

Aspartame affects the localization of SOX2 protein

NCBI chr 2:117,536,929...117,539,340
Ensembl chr 2:117,536,929...117,539,338

G

sterol regulatory element binding transcription factor 2

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SREBF2 mRNA

NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848

G

signal transducer and activator of transcription 3

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of STAT3 mRNA

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

SURF1, cytochrome c oxidase assembly factor

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of SURF1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SURF1 mRNA

NCBI chr 3:10,241,793...10,244,686
Ensembl chr 3:10,241,837...10,263,315

G

taste 1 receptor member 1

increases expression
multiple interactions

Aspartame results in increased expression of TAS1R1 protein
Aspartame promotes the reaction [TAS1R3 protein binds to TAS1R1 protein]; TAS1R1 protein affects the reaction [Aspartame affects the localization of CDKN1A protein]; TAS1R1 protein affects the reaction [Aspartame affects the localization of GLI1 protein]; TAS1R1 protein affects the reaction [Aspartame affects the localization of NOTCH1 protein modified form]

NCBI chr 5:162,533,838...162,546,408
Ensembl chr 5:162,533,841...162,545,562

G

taste 1 receptor member 2

multiple interactions
affects binding

Aspartame binds to and results in increased activity of TAS1R2 protein; Aspartame promotes the reaction [TAS1R3 protein binds to TAS1R2 protein]; lactisole inhibits the reaction [Aspartame results in increased activity of [TAS1R3 protein binds to TAS1R2 protein]]
Aspartame binds to [TAS1R2 protein binds to TAS1R3 protein]; Aspartame binds to TAS1R2 protein

PMID:15353592 PMID:17168764 PMID:17935609 PMID:20173092 PMID:33992720

NCBI chr 5:151,909,617...151,925,760
Ensembl chr 5:151,830,701...151,925,345

G

taste 1 receptor member 3

affects binding
decreases expression
multiple interactions

Aspartame binds to [TAS1R2 protein binds to TAS1R3 protein]
Aspartame results in decreased expression of TAS1R3 protein
Aspartame promotes the reaction [TAS1R3 protein binds to TAS1R1 protein]; Aspartame promotes the reaction [TAS1R3 protein binds to TAS1R2 protein]; lactisole inhibits the reaction [Aspartame results in increased activity of [TAS1R3 protein binds to TAS1R2 protein]]

PMID:17168764 PMID:17935609 PMID:33992720

NCBI chr 5:166,468,703...166,472,759
Ensembl chr 5:166,469,589...166,472,742

G

transcription factor A, mitochondrial

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of TFAM mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of TFAM mRNA

NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292

G

thrombospondin 1

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of THBS1 mRNA

NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440

G

tumor necrosis factor

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] results in increased expression of TNF protein; [Sodium Glutamate co-treated with Aspartame] promotes the reaction [Fats, Unsaturated results in increased expression of TNF protein]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

tumor protein p53

increases expression
multiple interactions

Aspartame results in increased expression of TRP53; Aspartame results in increased expression of TRP53 mRNA
[Fats, Unsaturated co-treated with Aspartame] affects the expression of TRP53 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of TRP53 mRNA

PMID:17354619 PMID:23783067 PMID:32951320

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

transient receptor potential cation channel, subfamily V, member 1

increases activity

Aspartame results in increased activity of TRPV1 protein

PMID:17567713 PMID:18804451

NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513

G

Tu translation elongation factor, mitochondrial

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of TUFM mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of TUFM mRNA

NCBI chr 1:181,073,788...181,077,395
Ensembl chr 1:181,073,788...181,077,395

G

uncoupling protein 2

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of UCP2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of UCP2 mRNA

NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611

G

ubiquinol-cytochrome c reductase, complex III subunit XI

multiple interactions

[Fats, Unsaturated co-treated with Aspartame] affects the expression of UQCR11 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of UQCR11 mRNA

NCBI chr 7:9,305,042...9,309,753
Ensembl chr 7:9,305,058...9,309,750

G

vascular endothelial growth factor A

increases secretion

Aspartame results in increased secretion of VEGFA protein

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

vimentin

increases expression

Aspartame results in increased expression of VIM protein

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

G

xanthine dehydrogenase

multiple interactions

[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of XDH mRNA

NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268

butamben

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

androgen receptor

affects binding

butamben binds to AR protein

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

mediator complex subunit 1

multiple interactions

butamben promotes the reaction [NR1I2.L protein binds to MED1 protein]; butamben promotes the reaction [NR1I2.S protein binds to MED1 protein]

NCBI chr10:83,145,538...83,189,260
Ensembl chr10:83,145,568...83,189,299

G

nuclear receptor coactivator 1

multiple interactions

butamben promotes the reaction [NR1I2.L protein binds to NCOA1 protein]; butamben promotes the reaction [NR1I2.S protein binds to NCOA1 protein]

NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664

G

nuclear receptor coactivator 2

multiple interactions

butamben promotes the reaction [NR1I2.L protein binds to NCOA2 protein]

NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451

G

nuclear receptor coactivator 3

multiple interactions

butamben promotes the reaction [NR1I2.L protein binds to NCOA3 protein]

NCBI chr 3:154,738,566...154,821,395
Ensembl chr 3:154,738,581...154,818,594

methyl L-leucinate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

tumor necrosis factor

multiple interactions

leucine methyl ester inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

methylphenidate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP/GTP binding carboxypeptidase 1

increases expression

Methylphenidate results in increased expression of AGTPBP1 mRNA

NCBI chr17:5,120,540...5,238,874
Ensembl chr17:5,120,609...5,238,869

G

aldo-keto reductase family 1 member B1

decreases expression

Methylphenidate results in decreased expression of AKR1B1 mRNA

NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157

G

adaptor related protein complex 2 subunit beta 1

increases expression

Methylphenidate results in increased expression of AP2B1 mRNA

NCBI chr10:68,099,397...68,205,023
Ensembl chr10:68,099,547...68,205,013

G

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1

decreases expression

Methylphenidate results in decreased expression of ARAP1 mRNA

NCBI chr 1:155,748,622...155,814,186
Ensembl chr 1:155,748,652...155,814,184

G

activity-regulated cytoskeleton-associated protein

affects expression

Methylphenidate affects the expression of ARC mRNA

NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378

G

ariadne RBR E3 ubiquitin protein ligase 2

decreases expression

Methylphenidate results in decreased expression of ARIH2 mRNA

NCBI chr 8:109,296,738...109,355,909
Ensembl chr 8:109,296,738...109,355,852

G

armadillo repeat containing 9

decreases expression

Methylphenidate results in decreased expression of ARMC9 mRNA

NCBI chr 9:86,802,791...86,928,611
Ensembl chr 9:86,802,868...86,928,860

G

autophagy related 5

increases expression

Methylphenidate results in increased expression of ATG5 mRNA

NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209

G

beta-1,4-galactosyltransferase 4

decreases expression

Methylphenidate results in decreased expression of B4GALT4 mRNA

NCBI chr11:61,995,807...62,021,751
Ensembl chr11:61,995,814...62,021,671

G

BCL2 associated X, apoptosis regulator

increases expression

Methylphenidate results in increased expression of BAX mRNA

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

Bcl-2 binding component 3

increases expression

Methylphenidate results in increased expression of BBC3 mRNA

NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509

G

BCL9, transcription coactivator

decreases expression

Methylphenidate results in decreased expression of BCL9 mRNA

NCBI chr 2:184,760,616...184,846,261
Ensembl chr 2:184,760,618...184,786,435

G

brain-derived neurotrophic factor

affects expression
multiple interactions
decreases expression

Methylphenidate affects the expression of BDNF mRNA
[staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] inhibits the reaction [Methylphenidate inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of BDNF protein]]; Methylphenidate inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of BDNF protein]
Methylphenidate results in decreased expression of BDNF mRNA

PMID:19222557 PMID:22470460 PMID:24394491

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

beclin 1

increases expression

Methylphenidate results in increased expression of BECN1 mRNA

PMID:32746681 PMID:32748667

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

G

complement C2

increases expression

Methylphenidate results in increased expression of C2 mRNA

NCBI chr20:3,951,474...3,970,376
Ensembl chr20:3,951,474...3,976,505

G

caldesmon 1

increases expression

Methylphenidate results in increased expression of CALD1 mRNA

NCBI chr 4:63,265,781...63,446,938
Ensembl chr 4:63,265,942...63,446,932

G

caspase 3

increases expression
multiple interactions

Methylphenidate results in increased expression of CASP3 mRNA
Methylphenidate results in increased expression of and results in increased activity of CASP3 protein

PMID:32746681 PMID:32748667

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

increases expression

Methylphenidate results in increased expression of CASP8 mRNA

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

multiple interactions

Methylphenidate results in increased expression of and results in increased activity of CASP9 protein

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

increases activity
decreases activity

Methylphenidate results in increased activity of CAT protein
Methylphenidate results in decreased activity of CAT protein

PMID:32746681 PMID:32748667

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

carbonyl reductase 3

increases expression

Methylphenidate results in increased expression of CBR3 mRNA

NCBI chr11:33,008,615...33,016,877
Ensembl chr11:33,008,615...33,016,875

G

coiled-coil domain containing 166

decreases expression

Methylphenidate results in decreased expression of CCDC166 mRNA

NCBI chr 7:107,693,572...107,695,375
Ensembl chr 7:107,693,574...107,695,375

G

coiled-coil domain containing 91

decreases expression

Methylphenidate results in decreased expression of CCDC91 mRNA

NCBI chr 4:180,402,327...180,574,364
Ensembl chr 4:180,402,376...180,574,364

G

cyclin-dependent kinase 5 regulatory subunit 1

increases expression

Methylphenidate results in increased expression of CDK5R1 mRNA

NCBI chr10:65,484,266...65,485,467
Ensembl chr10:65,483,941...65,488,456

G

cyclin-dependent kinase inhibitor 1A

increases expression

Methylphenidate results in increased expression of CDKN1A mRNA

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

carboxylesterase 1D

multiple interactions
increases hydrolysis
increases metabolic processing

[CES1 protein results in increased hydrolysis of Methylphenidate] which results in increased chemical synthesis of ritalinic acid; Aripiprazole inhibits the reaction [CES1 protein results in increased hydrolysis of Methylphenidate]; CES1 gene mutant form results in decreased metabolism of and results in increased abundance of Methylphenidate; Fluoxetine inhibits the reaction [CES1 protein results in increased hydrolysis of Methylphenidate]; Perphenazine inhibits the reaction [CES1 protein results in increased hydrolysis of Methylphenidate]; Thioridazine inhibits the reaction [CES1 protein results in increased hydrolysis of Methylphenidate]
aripiprazole inhibits the reaction [CES1 protein results in increased hydrolysis of Methylphenidate]
CES1 protein results in increased metabolism of Methylphenidate

PMID:15082749 PMID:18485328 PMID:20097249 PMID:25445008

NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035

G

chromodomain helicase DNA binding protein 2

increases expression

Methylphenidate results in increased expression of CHD2 mRNA

NCBI chr 1:127,188,146...127,317,041
Ensembl chr 1:127,190,059...127,300,502

G

chromogranin A

decreases expression

Methylphenidate results in decreased expression of CHGA mRNA

NCBI chr 6:121,696,051...121,707,399
Ensembl chr 6:121,696,051...121,707,398

G

chitinase domain containing 1

decreases expression

Methylphenidate results in decreased expression of CHID1 mRNA

NCBI chr 1:196,594,357...196,629,700
Ensembl chr 1:196,587,509...196,629,606

G

cholinergic receptor nicotinic alpha 6 subunit

decreases expression

Methylphenidate results in decreased expression of CHRNA6 mRNA

NCBI chr16:64,697,741...64,704,441
Ensembl chr16:64,697,741...64,704,441

G

carbohydrate sulfotransferase 8

decreases expression

Methylphenidate results in decreased expression of CHST8 mRNA

NCBI chr 1:87,294,144...87,435,900
Ensembl chr 1:87,294,540...87,435,900

G

caseinolytic mitochondrial matrix peptidase chaperone subunit X

increases expression

Methylphenidate results in increased expression of CLPX mRNA

NCBI chr 8:65,805,460...65,845,643
Ensembl chr 8:65,805,511...65,845,082

G

cyclin and CBS domain divalent metal cation transport mediator 1

increases expression

Methylphenidate results in increased expression of CNNM1 mRNA

NCBI chr 1:242,296,367...242,354,957
Ensembl chr 1:242,296,422...242,353,513

G

CCR4-NOT transcription complex, subunit 6-like

decreases expression

Methylphenidate results in decreased expression of CNOT6L mRNA

NCBI chr14:13,410,499...13,502,511
Ensembl chr14:13,411,281...13,498,203

G

cannabinoid receptor 1

increases expression

Methylphenidate results in increased expression of CNR1 mRNA

NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099

G

catechol-O-methyltransferase domain containing 1

decreases expression

Methylphenidate results in decreased expression of COMTD1 mRNA

NCBI chr15:2,459,783...2,462,895
Ensembl chr15:2,459,783...2,462,895

G

cAMP responsive element binding protein 1

multiple interactions
decreases expression

[Fluoxetine co-treated with Methylphenidate] results in increased expression of CREB1 mRNA; [Fluoxetine co-treated with Methylphenidate] results in increased phosphorylation of CREB1 protein
Methylphenidate results in decreased expression of CREB1 mRNA

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

G

D-2-hydroxyglutarate dehydrogenase

decreases expression

Methylphenidate results in decreased expression of D2HGDH mRNA

NCBI chr 9:94,350,555...94,368,384
Ensembl chr 9:94,350,576...94,368,382

G

DAB adaptor protein 2

increases expression

Methylphenidate results in increased expression of DAB2 mRNA

NCBI chr 2:55,514,692...55,567,476
Ensembl chr 2:55,514,700...55,567,476

G

death-associated protein kinase 3

decreases expression

Methylphenidate results in decreased expression of DAPK3 mRNA

NCBI chr 7:8,524,182...8,532,552
Ensembl chr 7:8,524,183...8,532,558

G

DEAH-box helicase 35

decreases expression

Methylphenidate results in decreased expression of DHX35 mRNA

NCBI chr 3:147,450,178...147,507,473
Ensembl chr 3:147,450,163...147,507,451

G

dopamine receptor D1

multiple interactions

[SCH 23390 binds to and results in decreased activity of DRD1 protein] which results in decreased susceptibility to Methylphenidate

NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002

G

dopamine receptor D2

multiple interactions
decreases expression
affects expression

[Raclopride binds to and results in decreased activity of DRD2 protein] which results in decreased susceptibility to Methylphenidate
Methylphenidate results in decreased expression of DRD2 mRNA
Methylphenidate affects the expression of DRD2 protein

PMID:11454915 PMID:17599397 PMID:22470460 PMID:33647392

NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875

G

dopamine receptor D4

affects response to substance

DRD4 promoter mutant form affects the susceptibility to Methylphenidate

NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553

G

early growth response 1

multiple interactions
increases expression

[Fluoxetine co-treated with Methylphenidate] results in increased expression of EGR1 mRNA; Fluoxetine promotes the reaction [Methylphenidate results in increased expression of EGR1 mRNA]; Methylphenidate promotes the reaction [Amphetamine results in increased expression of EGR1 mRNA]; SCH 23390 inhibits the reaction [Methylphenidate results in increased expression of EGR1 mRNA]

PMID:16549270 PMID:19931852 PMID:20020108 PMID:21753012

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

ectonucleoside triphosphate diphosphohydrolase 5

decreases expression

Methylphenidate results in decreased expression of ENTPD5 mRNA

NCBI chr 6:104,019,095...104,055,311
Ensembl chr 6:104,019,185...104,055,530

G

erythrocyte membrane protein band 4.1-like 1

decreases expression

Methylphenidate results in decreased expression of EPB41L1 mRNA

NCBI chr 3:144,929,195...145,052,723
Ensembl chr 3:144,984,640...145,052,721

G

EPH receptor A10

decreases expression

Methylphenidate results in decreased expression of EPHA10 mRNA

NCBI chr 5:137,139,588...137,175,637
Ensembl chr 5:137,140,735...137,174,157

G

exo/endonuclease G

decreases expression

Methylphenidate results in decreased expression of EXOG mRNA

NCBI chr 8:119,184,974...119,204,819
Ensembl chr 8:119,185,136...119,204,672

G

fibronectin type III and ankyrin repeat domains 1

decreases expression

Methylphenidate results in decreased expression of FANK1 mRNA

NCBI chr 1:188,577,512...188,685,501
Ensembl chr 1:188,577,575...188,685,504

G

Fc gamma receptor 2B

increases expression

Methylphenidate results in increased expression of FCGR2B mRNA

NCBI chr13:83,191,253...83,207,778
Ensembl chr13:83,193,163...83,207,778

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression
decreases expression

[Methylphenidate co-treated with SLC6A3 protein] results in increased expression of FOS protein; Methylphenidate inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS mRNA]; Methylphenidate inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS protein]
Methylphenidate results in increased expression of FOS mRNA
[Fluoxetine co-treated with Methylphenidate] results in increased expression of FOS mRNA; Fluoxetine promotes the reaction [Methylphenidate results in increased expression of FOS mRNA]
Methylphenidate results in increased expression of FOS protein
Methylphenidate results in decreased expression of FOS protein
SLC6A3 protein affects the reaction [Methylphenidate results in increased expression of FOS protein]
Methylphenidate results in increased expression of FOS mRNA; Methylphenidate results in increased expression of FOS protein

PMID:12112414 PMID:12699766 PMID:15916815 PMID:19931852 PMID:21753012

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

FosB proto-oncogene, AP-1 transcription factor subunit

increases expression

Methylphenidate results in increased expression of FOSB protein

NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465

G

polypeptide N-acetylgalactosaminyltransferase 10

decreases expression

Methylphenidate results in decreased expression of GALNT10 mRNA

NCBI chr10:41,821,216...41,967,618
Ensembl chr10:41,820,158...41,967,013

G

GTP cyclohydrolase 1

decreases expression

Methylphenidate results in decreased expression of GCH1 mRNA

NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698

G

glial cell derived neurotrophic factor

decreases expression

Methylphenidate results in decreased expression of GDNF mRNA

NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209

G

GH3 domain containing

decreases expression

Methylphenidate results in decreased expression of GHDC mRNA

NCBI chr10:85,693,612...85,697,833
Ensembl chr10:85,693,616...85,697,865

G

glutamate ionotropic receptor kainate type subunit 3

decreases expression

Methylphenidate results in decreased expression of GRIK3 mRNA

NCBI chr 5:137,767,865...137,989,617
Ensembl chr 5:137,767,865...137,984,307

G

glutathione-disulfide reductase

decreases activity

Methylphenidate results in decreased activity of GSR protein

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

guanylate cyclase 2C

decreases expression

Methylphenidate results in decreased expression of GUCY2C mRNA

NCBI chr 4:169,568,505...169,649,092
Ensembl chr 4:169,568,529...169,649,092

G

HMG-box transcription factor 1

decreases expression

Methylphenidate results in decreased expression of HBP1 mRNA

NCBI chr 6:48,529,633...48,555,775
Ensembl chr 6:48,529,372...48,555,787

G

high mobility group box 1

increases expression

Methylphenidate results in increased expression of HMGB1 mRNA

NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565

G

heme oxygenase 1

decreases expression

Methylphenidate results in decreased expression of HMOX1 protein

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

homer scaffold protein 1

increases expression
multiple interactions

Methylphenidate results in increased expression of HOMER1 mRNA
SCH 23390 inhibits the reaction [Methylphenidate results in increased expression of HOMER1 mRNA]

NCBI chr 2:24,542,777...24,645,715
Ensembl chr 2:24,543,093...24,644,785

G

heat shock protein family B (small) member 6

decreases expression

Methylphenidate results in decreased expression of HSPB6 mRNA

NCBI chr 1:85,806,898...85,809,072
Ensembl chr 1:85,806,146...85,809,071

G

5-hydroxytryptamine receptor 1A

decreases expression

Methylphenidate decreases expression of Htr1a mRNA in the nucleus accumbens

RGD

NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442

G

interleukin 1 beta

increases expression

Methylphenidate results in increased expression of IL1B mRNA

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

increases expression

Methylphenidate results in increased expression of IL6 mRNA

PMID:22470460 PMID:32746681

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

inositol hexakisphosphate kinase 1

increases expression

Methylphenidate results in increased expression of IP6K1 mRNA

NCBI chr 8:108,693,068...108,737,278

G

Janus kinase 1

increases phosphorylation

Methylphenidate results in increased phosphorylation of JAK1 protein

NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926

G

Janus kinase 3

decreases expression

Methylphenidate results in decreased expression of JAK3 mRNA

NCBI chr16:18,386,330...18,398,542
Ensembl chr16:18,386,405...18,398,536

G

kinesin family member C3

decreases expression

Methylphenidate results in decreased expression of KIFC3 mRNA

NCBI chr19:9,825,114...9,920,371
Ensembl chr19:9,886,693...9,920,451

G

ladinin 1

decreases expression

Methylphenidate results in decreased expression of LAD1 mRNA

NCBI chr13:47,249,605...47,263,967
Ensembl chr13:47,249,605...47,263,967

G

laminin subunit alpha 3

decreases expression

Methylphenidate results in decreased expression of LAMA3 mRNA

NCBI chr18:3,523,168...3,751,722
Ensembl chr18:3,523,133...3,751,353

G

lysosomal-associated membrane protein 2

increases expression

Methylphenidate results in increased expression of LAMP2 mRNA

NCBI chr X:117,173,097...117,222,090
Ensembl chr X:117,057,606...117,260,522

G

LARGE xylosyl- and glucuronyltransferase 1

decreases expression

Methylphenidate results in decreased expression of LARGE1 mRNA

NCBI chr19:11,603,129...12,048,930
Ensembl chr19:11,603,129...12,048,930

G

LIM and SH3 protein 1

increases expression

Methylphenidate results in increased expression of LASP1 mRNA

NCBI chr10:82,795,177...82,835,659
Ensembl chr10:82,795,137...82,943,292

G

galectin 3 binding protein

decreases expression

Methylphenidate results in decreased expression of LGALS3BP mRNA

NCBI chr10:103,619,912...103,629,251
Ensembl chr10:103,619,908...103,629,256

G

LHFPL tetraspan subfamily member 5

decreases expression

Methylphenidate results in decreased expression of LHFPL5 mRNA

NCBI chr20:6,632,324...6,642,534
Ensembl chr20:6,632,362...6,642,532

G

leucine rich repeat containing 27

decreases expression

Methylphenidate results in decreased expression of LRRC27 mRNA

NCBI chr 1:194,004,967...194,035,087
Ensembl chr 1:194,005,182...194,035,084

G

microtubule-associated protein 1 light chain 3 beta

decreases expression
increases expression

Methylphenidate results in decreased expression of MAP1LC3B mRNA
Methylphenidate results in increased expression of MAP1LC3B protein
Methylphenidate results in increased expression of MAP1LC3B mRNA

PMID:22470460 PMID:32746681 PMID:32748667

NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690

G

mitogen activated protein kinase 1

decreases expression
multiple interactions

Methylphenidate results in decreased expression of MAPK1 mRNA
[Fluoxetine co-treated with Methylphenidate] results in increased expression of MAPK1 mRNA; [Fluoxetine co-treated with Methylphenidate] results in increased phosphorylation of MAPK1 protein

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen-activated protein kinase 8

increases expression

Methylphenidate results in increased expression of MAPK8 mRNA

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

modulator of VRAC current 1

decreases expression

Methylphenidate results in decreased expression of MLC1 mRNA

NCBI chr 7:120,046,705...120,067,049
Ensembl chr 7:120,046,705...120,067,049

G

MORN repeat containing 2

decreases expression

Methylphenidate results in decreased expression of MORN2 mRNA

NCBI chr 6:14,718,799...14,725,281

G

mechanistic target of rapamycin kinase

multiple interactions
increases expression
affects expression

[Fluoxetine co-treated with Methylphenidate] results in increased expression of MTOR mRNA; [Fluoxetine co-treated with Methylphenidate] results in increased phosphorylation of MTOR protein
Methylphenidate results in increased expression of MTOR mRNA
Methylphenidate affects the expression of MTOR mRNA

PMID:21753012 PMID:32746681

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

major vault protein

decreases expression

Methylphenidate results in decreased expression of MVP mRNA

NCBI chr 1:181,594,734...181,622,336
Ensembl chr 1:181,594,734...181,622,380

G

nucleic acid binding protein 1

increases expression

Methylphenidate results in increased expression of NABP1 mRNA

NCBI chr 9:50,098,552...50,133,982
Ensembl chr 9:50,126,726...50,134,107

G

NAC alpha domain containing

decreases expression

Methylphenidate results in decreased expression of NACAD mRNA

NCBI chr14:81,465,299...81,473,866
Ensembl chr14:81,465,299...81,473,781

G

nuclear receptor co-repressor 2

decreases expression

Methylphenidate results in decreased expression of NCOR2 mRNA

NCBI chr12:31,466,418...31,628,319
Ensembl chr12:31,466,412...31,628,319

G

neuropilin and tolloid like 2

increases expression

Methylphenidate results in increased expression of NETO2 mRNA

NCBI chr19:21,344,299...21,415,524
Ensembl chr19:21,344,289...21,417,023

G

nucleolar protein 3

decreases expression

Methylphenidate results in decreased expression of NOL3 mRNA

NCBI chr19:33,154,061...33,158,250
Ensembl chr19:33,154,062...33,158,250

G

NADPH oxidase 4

increases expression

Methylphenidate results in increased expression of NOX4 protein

NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406

G

NOP2/Sun RNA methyltransferase 4

increases expression

Methylphenidate results in increased expression of NSUN4 mRNA

NCBI chr 5:129,511,224...129,532,498
Ensembl chr 5:129,512,307...129,532,423
Ensembl chr 5:129,512,307...129,532,423

G

neurotrophic receptor tyrosine kinase 2

multiple interactions

[staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] inhibits the reaction [Methylphenidate inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of BDNF protein]]

NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136

G

poly (ADP-ribose) polymerase family, member 3

increases expression

Methylphenidate results in increased expression of PARP3 mRNA

NCBI chr 8:107,111,010...107,117,073
Ensembl chr 8:107,111,012...107,116,782

G

platelet endothelial aggregation receptor 1

increases expression

Methylphenidate results in increased expression of PEAR1 mRNA

NCBI chr 2:173,206,298...173,234,106
Ensembl chr 2:173,207,664...173,227,440

G

plasmanylethanolamine desaturase 1

decreases expression

Methylphenidate results in decreased expression of PEDS1 mRNA

NCBI chr 3:156,350,135...156,369,309
Ensembl chr 3:156,349,526...156,369,314

G

phosphatidylserine decarboxylase

decreases expression

Methylphenidate results in decreased expression of PISD mRNA

NCBI chr14:77,941,927...77,991,021
Ensembl chr14:77,941,948...77,991,003

G

protein kinase N1

decreases expression

Methylphenidate results in decreased expression of PKN1 mRNA

NCBI chr19:24,442,130...24,470,107
Ensembl chr19:24,442,122...24,470,107

G

PNMA family member 8B

increases expression

Methylphenidate results in increased expression of PNMA8B mRNA

NCBI chr 1:77,622,287...77,626,525
Ensembl chr 1:77,622,283...77,627,148

G

protein kinase cGMP-dependent 2

increases expression

Methylphenidate results in increased expression of PRKG2 mRNA

NCBI chr14:10,559,882...10,668,479
Ensembl chr14:10,559,882...10,666,888

G

prolactin receptor

decreases expression

Methylphenidate results in decreased expression of PRLR mRNA

NCBI chr 2:59,134,147...59,324,719
Ensembl chr 2:59,134,588...59,324,718

G

pre-mRNA processing factor 39

increases expression

Methylphenidate results in increased expression of PRPF39 mRNA

NCBI chr 6:83,088,981...83,113,826
Ensembl chr 6:83,088,986...83,113,825

G

phosphatidylserine synthase 2

decreases expression

Methylphenidate results in decreased expression of PTDSS2 mRNA

NCBI chr 1:196,241,439...196,267,632
Ensembl chr 1:196,241,494...196,267,685

G

protein tyrosine phosphatase, non-receptor type 21

increases expression

Methylphenidate results in increased expression of PTPN21 mRNA

NCBI chr 6:117,933,066...117,998,095
Ensembl chr 6:117,933,066...117,998,095

G

pseudouridine synthase 7 like

decreases expression

Methylphenidate results in decreased expression of PUS7L mRNA

NCBI chr 7:125,659,507...125,706,582
Ensembl chr 7:125,659,507...125,682,333

G

RAB38, member RAS oncogene family

increases expression

Methylphenidate results in increased expression of RAB38 mRNA

NCBI chr 1:142,182,566...142,262,923
Ensembl chr 1:142,182,556...142,262,924

G

Rac GTPase-activating protein 1

decreases expression

Methylphenidate results in decreased expression of RACGAP1 mRNA

NCBI chr 7:130,750,936...130,780,891
Ensembl chr 7:130,750,936...130,780,831

G

RNA binding fox-1 homolog 1

increases expression

Methylphenidate results in increased expression of RBFOX1 mRNA

NCBI chr10:8,152,198...10,248,120
Ensembl chr10:8,152,198...9,686,659

G

regulator of chromosome condensation 2

decreases expression

Methylphenidate results in decreased expression of RCC2 mRNA

NCBI chr 5:152,994,406...153,017,223
Ensembl chr 5:152,993,665...153,017,205

G

ret proto-oncogene

decreases expression

Methylphenidate results in decreased expression of RET mRNA

NCBI chr 4:151,325,969...151,368,176
Ensembl chr 4:151,326,431...151,368,176

G

repulsive guidance molecule BMP co-receptor a

decreases expression

Methylphenidate results in decreased expression of RGMA mRNA

NCBI chr 1:127,128,934...127,172,918
Ensembl chr 1:127,128,934...127,172,918

G

regulator of G-protein signaling 20

decreases expression

Methylphenidate results in decreased expression of RGS20 mRNA

NCBI chr 5:14,484,436...14,614,317
Ensembl chr 5:14,534,775...14,614,084

G

rhomboid domain containing 2

decreases expression

Methylphenidate results in decreased expression of RHBDD2 mRNA

NCBI chr12:21,043,605...21,054,305
Ensembl chr12:21,043,608...21,054,289

G

syndecan 3

decreases expression

Methylphenidate results in decreased expression of SDC3 mRNA

NCBI chr 5:142,965,659...142,998,390
Ensembl chr 5:142,965,591...142,996,480

G

sialic acid acetylesterase

decreases expression

Methylphenidate results in decreased expression of SIAE mRNA

NCBI chr 8:37,318,724...37,354,004
Ensembl chr 8:37,318,747...37,353,996

G

solute carrier family 10, member 4

decreases expression

Methylphenidate results in decreased expression of SLC10A4 mRNA

NCBI chr14:35,198,149...35,203,863
Ensembl chr14:35,197,886...35,203,729

G

solute carrier family 18 member A2

decreases expression
decreases activity

Methylphenidate results in decreased expression of SLC18A2 mRNA
Methylphenidate results in decreased activity of SLC18A2 protein

PMID:22470460 PMID:33378168

NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325

G

solute carrier family 2 member 12

increases expression

Methylphenidate results in increased expression of SLC2A12 mRNA

NCBI chr 1:22,803,068...22,862,204
Ensembl chr 1:22,804,418...22,860,971

G

solute carrier family 6 member 3

multiple interactions
decreases expression
increases response to substance
affects response to substance

[Methylphenidate co-treated with SLC6A3 protein] results in increased expression of FOS protein; [SLC6A3 protein polymorphism affects the susceptibility to Methylphenidate] which affects the uptake of Dopamine; Methylphenidate inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS mRNA]; Methylphenidate inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS protein]; Methylphenidate inhibits the reaction [SLC6A3 protein mutant form results in increased export of Dopamine]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]
Methylphenidate results in decreased expression of SLC6A3 mRNA
Methylphenidate results in decreased expression of SLC6A3 protein
SLC6A3 protein results in increased susceptibility to Methylphenidate
SLC6A3 protein affects the reaction [Methylphenidate results in increased expression of FOS protein]
SLC6A3 3' UTR polymorphism affects the susceptibility to Methylphenidate; SLC6A3 protein polymorphism affects the susceptibility to Methylphenidate

PMID:12112414 PMID:12699766 PMID:15059031 PMID:16139732 PMID:17234900 More...

NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413

G

synaptosome associated protein 25

affects response to substance

SNAP25 gene polymorphism affects the susceptibility to Methylphenidate

NCBI chr 3:124,041,898...124,123,761
Ensembl chr 3:124,041,898...124,123,760

G

synuclein, alpha interacting protein

increases expression

Methylphenidate results in increased expression of SNCAIP mRNA

NCBI chr18:46,205,846...46,343,932
Ensembl chr18:46,207,152...46,343,929

G

synuclein, gamma

decreases expression

Methylphenidate results in decreased expression of SNCG mRNA

NCBI chr16:9,700,513...9,705,751
Ensembl chr16:9,700,514...9,705,368

G

sorting nexin 22

decreases expression

Methylphenidate results in decreased expression of SNX22 mRNA

NCBI chr 8:66,609,914...66,612,932
Ensembl chr 8:66,609,970...66,612,850

G

sortilin-related VPS10 domain containing receptor 3

decreases expression

Methylphenidate results in decreased expression of SORCS3 mRNA

NCBI chr 1:247,099,178...247,734,027
Ensembl chr 1:247,099,408...247,734,027

G

SRY-box transcription factor 11

increases expression

Methylphenidate results in increased expression of SOX11 mRNA

NCBI chr 6:44,008,333...44,010,354
Ensembl chr 6:44,008,340...44,010,354

G

signal transducer and activator of transcription 1

increases phosphorylation

Methylphenidate results in increased phosphorylation of STAT1 protein

NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540

G

signal transducer and activator of transcription 5A

decreases expression

Methylphenidate results in decreased expression of STAT5A mRNA

NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866

G

storkhead box 2

increases expression

Methylphenidate results in increased expression of STOX2 mRNA

NCBI chr16:44,848,179...45,087,238
Ensembl chr16:44,848,078...45,085,105

G

SDS3 homolog, SIN3A corepressor complex component

decreases expression

Methylphenidate results in decreased expression of SUDS3 mRNA

NCBI chr12:39,477,181...39,499,633
Ensembl chr12:39,477,568...39,499,628

G

trace-amine-associated receptor 1

multiple interactions

Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]]

NCBI chr 1:21,517,742...21,518,740
Ensembl chr 1:21,517,258...21,532,084

G

tyrosine hydroxylase

decreases expression

Methylphenidate results in decreased expression of TH mRNA

NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767

G

transmembrane protein 185B

decreases expression

Methylphenidate results in decreased expression of TMEM185B mRNA

NCBI chr13:30,647,533...30,650,864
Ensembl chr13:30,647,482...30,650,858

G

transmembrane protein 30A

decreases expression

Methylphenidate results in decreased expression of TMEM30A mRNA

NCBI chr 8:80,728,749...80,757,197
Ensembl chr 8:80,729,619...80,753,248

G

tumor necrosis factor

increases expression

Methylphenidate results in increased expression of TNF mRNA

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor-associated factor 5

decreases expression

Methylphenidate results in decreased expression of TRAF5 mRNA

NCBI chr13:103,569,944...103,618,747
Ensembl chr13:103,572,314...103,618,709

G

tripartite motif-containing 25

increases expression

Methylphenidate results in increased expression of TRIM25 mRNA

NCBI chr10:73,812,818...73,831,271
Ensembl chr10:73,812,818...73,831,257

G

tetraspanin 17

decreases expression

Methylphenidate results in decreased expression of TSPAN17 mRNA

NCBI chr17:9,819,212...9,826,851
Ensembl chr17:9,819,202...9,826,834

G

transcription termination factor 1

increases expression

Methylphenidate results in increased expression of TTF1 mRNA

NCBI chr 3:12,384,626...12,409,257
Ensembl chr 3:12,384,655...12,409,257

G

twisted gastrulation BMP signaling modulator 1

decreases expression

Methylphenidate results in decreased expression of TWSG1 mRNA

NCBI chr 9:105,533,116...105,567,460
Ensembl chr 9:105,533,136...105,567,479

G

ubiquitin protein ligase E3D

decreases expression

Methylphenidate results in decreased expression of UBE3D mRNA

NCBI chr 8:87,245,503...87,413,104
Ensembl chr 8:87,245,589...87,413,057

G

UBX domain protein 10

decreases expression

Methylphenidate results in decreased expression of UBXN10 mRNA

NCBI chr 5:150,953,772...150,959,608
Ensembl chr 5:150,950,731...150,959,744

G

uridine-cytidine kinase 2

decreases expression

Methylphenidate results in decreased expression of UCK2 mRNA

NCBI chr13:79,380,807...79,438,121
Ensembl chr13:79,383,846...79,438,352

G

vasohibin 1

increases expression

Methylphenidate results in increased expression of VASH1 mRNA

NCBI chr 6:106,330,374...106,345,740
Ensembl chr 6:106,329,123...106,345,726

G

tryptophanyl tRNA synthetase 2 (mitochondrial)

decreases expression

Methylphenidate results in decreased expression of WARS2 mRNA

NCBI chr 2:186,459,744...186,543,581
Ensembl chr 2:186,459,444...186,543,571

G

ZFP14 zinc finger protein

decreases expression

Methylphenidate results in decreased expression of ZFP14 mRNA

NCBI chr 1:85,268,649...85,286,125
Ensembl chr 1:85,268,643...85,285,759

N(gamma)-nitro-L-arginine methyl ester

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensin I converting enzyme

multiple interactions
increases activity

[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of ACE protein; bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased activity of ACE protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of ACE protein]; naringin inhibits the reaction [bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased activity of ACE protein]]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester promotes the reaction [bisphenol A results in increased activity of ACE protein]]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased activity of ACE protein]; NG-Nitroarginine Methyl Ester promotes the reaction [bisphenol A results in increased activity of ACE protein]

PMID:32172062 PMID:32810514 PMID:34797181 PMID:37718616 PMID:38029875

NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131

G

acetylcholinesterase

increases expression
increases activity
multiple interactions

NG-Nitroarginine Methyl Ester results in increased expression of ACHE protein
NG-Nitroarginine Methyl Ester results in increased activity of ACHE protein
[NG-Nitroarginine Methyl Ester co-treated with bisphenol A co-treated with naringin] results in increased expression of ACHE protein; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of ACHE protein; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of ACHE protein; [NG-Nitroarginine Methyl Ester co-treated with naringin] results in increased expression of ACHE protein; bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased expression of ACHE protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of ACHE protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of ACHE protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased activity of ACHE protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of ACHE protein]; NG-Nitroarginine Methyl Ester promotes the reaction [bisphenol A results in increased expression of ACHE protein]

PMID:32172062 PMID:32428650 PMID:32772714 PMID:32810514

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

actin alpha 2, smooth muscle

multiple interactions
increases expression

[Huang Qi co-treated with Coptidis rhizoma extract co-treated with Aconitic Acid co-treated with Centella asiatica extract] inhibits the reaction [[Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of ACTA2 mRNA]; [Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of ACTA2 mRNA; [Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of ACTA2 protein
NG-Nitroarginine Methyl Ester results in increased expression of ACTA2 mRNA
bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased expression of ACTA2 mRNA]

PMID:37718616 PMID:38282657

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

adenosine deaminase

multiple interactions
increases activity

[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of ADA protein; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of ADA protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased activity of ADA protein]

PMID:32172062 PMID:32428650 PMID:32810514

NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088

G

adrenomedullin

increases expression

NG-Nitroarginine Methyl Ester results in increased expression of ADM mRNA

NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654

G

angiotensinogen

multiple interactions

NG-Nitroarginine Methyl Ester inhibits the reaction [AGT protein results in increased activity of PARP1 protein]

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

angiotensin II receptor, type 1b

increases expression
multiple interactions

NG-Nitroarginine Methyl Ester results in increased expression of AGTR1B protein
Sildenafil Citrate inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of AGTR1B protein]; tangeretin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of AGTR1B protein]

NCBI chr 2:102,844,969...102,920,232
Ensembl chr 2:102,844,969...102,920,232

G

activated leukocyte cell adhesion molecule

multiple interactions
decreases expression

ALKBH5 protein promotes the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of ALCAM protein]

NCBI chr11:48,336,123...48,536,296
Ensembl chr11:48,336,169...48,537,954

G

alkB homolog 5, RNA demethylase

multiple interactions
increases response to substance
increases expression

ALKBH5 protein promotes the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of ALCAM protein]; ALKBH5 protein promotes the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of CTNNB1 protein]; ALKBH5 protein promotes the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of MYC protein]; ALKBH5 protein promotes the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of PPARG protein]; ALKBH5 protein promotes the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of VIM protein]; ALKBH5 protein promotes the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of WNT2 protein]; ALKBH5 protein promotes the reaction [NG-Nitroarginine Methyl Ester results in increased expression of CDH1 protein]; ALKBH5 protein promotes the reaction [NG-Nitroarginine Methyl Ester results in increased expression of ENG protein]
ALKBH5 protein results in increased susceptibility to NG-Nitroarginine Methyl Ester
NG-Nitroarginine Methyl Ester results in increased expression of ALKBH5 protein

NCBI chr10:45,344,888...45,366,331
Ensembl chr10:45,343,395...45,366,331

G

activating transcription factor 3

multiple interactions

[Huang Qi co-treated with Coptidis rhizoma extract co-treated with Aconitic Acid co-treated with Centella asiatica extract] inhibits the reaction [[Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in decreased expression of ATF3 mRNA]; [Huang Qi co-treated with Coptidis rhizoma extract co-treated with Aconitic Acid co-treated with Centella asiatica extract] inhibits the reaction [[Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in decreased expression of ATF3 protein]; [Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in decreased expression of ATF3 mRNA; [Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in decreased expression of ATF3 protein

NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631

G

butyrylcholinesterase

multiple interactions
increases activity

[bisphenol A co-treated with NG-Nitroarginine Methyl Ester] results in increased activity of BCHE protein; naringin inhibits the reaction [[bisphenol A co-treated with NG-Nitroarginine Methyl Ester] results in increased activity of BCHE protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased activity of BCHE protein]

NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148

G

beclin 1

multiple interactions

[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of BECN1 protein; Berberine promotes the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of BECN1 protein]

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

G

BCL2 interacting protein 3

multiple interactions

[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of BNIP3 protein; Berberine promotes the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of BNIP3 protein]

NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359

G

caspase 1

multiple interactions

[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of and results in increased cleavage of CASP1 protein; [Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of CASP1 mRNA; Berberine inhibits the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of and results in increased cleavage of CASP1 protein]; Berberine inhibits the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of CASP1 mRNA]

NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383

G

caspase 9

multiple interactions
increases expression

[NG-Nitroarginine Methyl Ester co-treated with bisphenol A co-treated with naringin] results in decreased expression of CASP9 protein; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of CASP9 protein; bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased expression of CASP9 protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of CASP9 protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of CASP9 protein]; NG-Nitroarginine Methyl Ester inhibits the reaction [bisphenol A results in increased expression of CASP9 protein]

PMID:32172062 PMID:32428650 PMID:32810514

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

multiple interactions
decreases activity

bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in decreased activity of CAT protein]; bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased activity of CAT protein]

PMID:37718616 PMID:38029875

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 2

multiple interactions

[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of CCL2 mRNA; [Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of CCL2 protein; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of CCL2 protein]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of CCL2 mRNA]]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of CCL2 protein]]; Particulate Matter inhibits the reaction [alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of CCL2 protein]]; Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of CCL2 mRNA]; Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of CCL2 protein]
[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of CCL2 mRNA; Berberine inhibits the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of CCL2 mRNA]

PMID:29423081 PMID:38705399

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

cadherin 1

increases expression
multiple interactions

NG-Nitroarginine Methyl Ester results in increased expression of CDH1 protein
ALKBH5 protein promotes the reaction [NG-Nitroarginine Methyl Ester results in increased expression of CDH1 protein]

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

CUGBP, Elav-like family member 2

multiple interactions

[Huang Qi co-treated with Coptidis rhizoma extract co-treated with Aconitic Acid co-treated with Centella asiatica extract] inhibits the reaction [[Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in decreased expression of CELF2 mRNA]; [Huang Qi co-treated with Coptidis rhizoma extract co-treated with Aconitic Acid co-treated with Centella asiatica extract] inhibits the reaction [[Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in decreased expression of CELF2 protein]; [Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in decreased expression of CELF2 mRNA; [Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in decreased expression of CELF2 protein

NCBI chr17:70,904,462...71,729,072
Ensembl chr17:71,210,853...71,728,333

G

cytoplasmic polyadenylation element binding protein 2

multiple interactions

[Huang Qi co-treated with Coptidis rhizoma extract co-treated with Aconitic Acid co-treated with Centella asiatica extract] inhibits the reaction [[Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in decreased expression of CPEB2 mRNA]; [Huang Qi co-treated with Coptidis rhizoma extract co-treated with Aconitic Acid co-treated with Centella asiatica extract] inhibits the reaction [[Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in decreased expression of CPEB2 protein]

NCBI chr14:67,787,503...67,839,973
Ensembl chr14:67,787,507...67,840,743

G

cytoplasmic polyadenylation element binding protein 4

multiple interactions

[Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in decreased expression of CPEB4 mRNA; [Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in decreased expression of CPEB4 protein

NCBI chr10:15,717,794...15,780,482
Ensembl chr10:15,717,794...15,780,603

G

cystatin C

multiple interactions

[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of CST3 protein; Berberine inhibits the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of CST3 protein]

NCBI chr 3:136,336,923...136,340,796
Ensembl chr 3:136,336,920...136,340,822

G

catenin beta 1

multiple interactions
decreases expression

ALKBH5 protein promotes the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of CTNNB1 protein]

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

cytochrome b-245 beta chain

increases expression
multiple interactions

NG-Nitroarginine Methyl Ester results in increased expression of CYBB protein
Sildenafil Citrate inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of CYBB protein]; tangeretin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of CYBB protein]

NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586

G

DNA-damage inducible transcript 3

multiple interactions

[Huang Qi co-treated with Coptidis rhizoma extract co-treated with Aconitic Acid co-treated with Centella asiatica extract] inhibits the reaction [[Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of DDIT3 mRNA]; [Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of DDIT3 mRNA

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

ER degradation enhancing alpha-mannosidase like protein 3

multiple interactions

[Huang Qi co-treated with Coptidis rhizoma extract co-treated with Aconitic Acid co-treated with Centella asiatica extract] inhibits the reaction [[Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in decreased expression of EDEM3 mRNA]; [Huang Qi co-treated with Coptidis rhizoma extract co-treated with Aconitic Acid co-treated with Centella asiatica extract] inhibits the reaction [[Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in decreased expression of EDEM3 protein]; [Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in decreased expression of EDEM3 mRNA; [Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in decreased expression of EDEM3 protein

NCBI chr13:63,858,282...63,920,538
Ensembl chr13:63,858,716...63,920,523

G

endothelin 1

increases expression

NG-Nitroarginine Methyl Ester results in increased expression of EDN1 mRNA

NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885

G

endothelin receptor type A

multiple interactions
increases expression

Atrasentan inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of EDNRA mRNA]

NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049

G

endothelin receptor type B

decreases expression
multiple interactions

NG-Nitroarginine Methyl Ester results in decreased expression of EDNRB mRNA
Atrasentan inhibits the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of EDNRB mRNA]

NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115

G

endoglin

increases expression
multiple interactions

NG-Nitroarginine Methyl Ester results in increased expression of ENG protein
ALKBH5 protein promotes the reaction [NG-Nitroarginine Methyl Ester results in increased expression of ENG protein]

NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230

G

fibronectin 1

multiple interactions

[Huang Qi co-treated with Coptidis rhizoma extract co-treated with Aconitic Acid co-treated with Centella asiatica extract] inhibits the reaction [[Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of FN1 protein]; [Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of FN1 protein

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

glutamic--pyruvic transaminase

multiple interactions

NG-Nitroarginine Methyl Ester promotes the reaction [cupric nitrilotriacetate results in increased activity of GPT protein]

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glutathione peroxidase 1

decreases activity
multiple interactions

NG-Nitroarginine Methyl Ester results in decreased activity of GPX1 protein
bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in decreased activity of GPX1 protein]

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

hypoxia inducible factor 1 subunit alpha

multiple interactions

NG-Nitroarginine Methyl Ester inhibits the reaction [Folic Acid inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]]

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

high mobility group box 1

multiple interactions

[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of HMGB1 protein; Berberine inhibits the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of HMGB1 protein]

NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565

G

heat shock protein family A (Hsp70) member 5

multiple interactions

[Huang Qi co-treated with Coptidis rhizoma extract co-treated with Aconitic Acid co-treated with Centella asiatica extract] inhibits the reaction [[Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of HSPA5 mRNA]; [Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of HSPA5 mRNA

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

isocitrate dehydrogenase (NADP(+)) 1

decreases activity
multiple interactions

NG-Nitroarginine Methyl Ester results in decreased activity of IDH1 protein
bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in decreased activity of IDH1 protein]

NCBI chr 9:66,534,146...66,563,703
Ensembl chr 9:66,534,146...66,563,708

G

interferon gamma

multiple interactions

[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IFNG mRNA; [Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IFNG protein; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IFNG mRNA]; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IFNG protein]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IFNG mRNA]]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IFNG protein]]; Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IFNG mRNA]; Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IFNG protein]

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interleukin 1 alpha

multiple interactions

NG-Nitroarginine Methyl Ester inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of IL1A mRNA]

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

increases expression
multiple interactions

NG-Nitroarginine Methyl Ester results in increased expression of IL1B protein
[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of IL1B mRNA; [Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of IL1B protein; Berberine inhibits the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of IL1B mRNA]; Berberine inhibits the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of IL1B protein]
[NG-Nitroarginine Methyl Ester co-treated with bisphenol A co-treated with naringin] results in increased expression of IL1B protein; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of IL1B protein; [NG-Nitroarginine Methyl Ester co-treated with naringin] results in increased expression of IL1B protein; bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased expression of IL1B protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of IL1B protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of IL1B protein]; NG-Nitroarginine Methyl Ester promotes the reaction [bisphenol A results in increased expression of IL1B protein]

PMID:32172062 PMID:32428650 PMID:32810514 PMID:38705399

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions
increases expression

[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IL6 mRNA; [Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IL6 protein; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IL6 mRNA]; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IL6 protein]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IL6 mRNA]]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IL6 protein]]; bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased expression of IL6 mRNA]; bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased expression of IL6 protein]; Particulate Matter inhibits the reaction [alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IL6 mRNA]]; Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IL6 mRNA]; Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IL6 protein]
[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of IL6 mRNA; Berberine inhibits the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of IL6 mRNA]
NG-Nitroarginine Methyl Ester results in increased expression of IL6 mRNA; NG-Nitroarginine Methyl Ester results in increased expression of IL6 protein

PMID:29423081 PMID:37718616 PMID:38029875 PMID:38705399

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

laminin subunit alpha 1

multiple interactions

[Huang Qi co-treated with Coptidis rhizoma extract co-treated with Aconitic Acid co-treated with Centella asiatica extract] inhibits the reaction [[Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of LAMA1 protein]; [Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of LAMA1 protein

NCBI chr 9:107,692,770...107,816,847
Ensembl chr 9:107,692,770...107,817,478

G

monoamine oxidase A

increases expression
increases activity
multiple interactions

NG-Nitroarginine Methyl Ester results in increased expression of MAOA protein
NG-Nitroarginine Methyl Ester results in increased activity of MAOA protein
[NG-Nitroarginine Methyl Ester co-treated with bisphenol A co-treated with naringin] results in increased expression of MAOA protein; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of MAOA protein; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of MAOA protein; bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased activity of MAOA protein]; bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased expression of MAOA protein]; naringin inhibits the reaction [[bisphenol A co-treated with NG-Nitroarginine Methyl Ester] results in increased activity of MAOA protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of MAOA protein]; naringin inhibits the reaction [bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased activity of MAOA protein]]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester promotes the reaction [bisphenol A results in increased activity of MAOA protein]]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased activity of MAOA protein]; NG-Nitroarginine Methyl Ester promotes the reaction [bisphenol A results in increased activity of MAOA protein]; NG-Nitroarginine Methyl Ester promotes the reaction [bisphenol A results in increased expression of MAOA protein]

PMID:32172062 PMID:32428650 PMID:32810514

NCBI chr X:6,032,172...6,098,308
Ensembl chr X:6,030,795...6,099,593

G

MCL1 apoptosis regulator, BCL2 family member

decreases expression

NG-Nitroarginine Methyl Ester results in decreased expression of MCL1 mRNA

NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303

G

malate dehydrogenase 2

multiple interactions
decreases activity

bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in decreased activity of MDH2 protein]

NCBI chr12:20,894,269...20,907,225
Ensembl chr12:20,894,262...20,907,271

G

microRNA 377

multiple interactions

[Huang Qi co-treated with Coptidis rhizoma extract co-treated with Aconitic Acid co-treated with Centella asiatica extract] inhibits the reaction [[Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of MIR377]; [Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of MIR377

NCBI chr 6:128,755,051...128,755,122

G

microRNA 494

multiple interactions

[Huang Qi co-treated with Coptidis rhizoma extract co-treated with Aconitic Acid co-treated with Centella asiatica extract] inhibits the reaction [[Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of MIR494]; [Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of MIR494

NCBI chr 6:128,728,710...128,728,792
Ensembl chr 6:128,728,709...128,728,793

G

myeloperoxidase

multiple interactions

NG-Nitroarginine Methyl Ester inhibits the reaction [caffeic acid inhibits the reaction [Ethanol results in increased activity of MPO protein]]

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

MYC proto-oncogene, bHLH transcription factor

decreases expression
multiple interactions

NG-Nitroarginine Methyl Ester results in decreased expression of MYC protein
ALKBH5 protein promotes the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of MYC protein]

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

NFKB inhibitor beta

multiple interactions

NG-Nitroarginine Methyl Ester inhibits the reaction [Arginine inhibits the reaction [Indomethacin results in increased expression of NFKBIB mRNA]]

NCBI chr 1:84,046,292...84,053,862
Ensembl chr 1:84,046,295...84,053,862

G

NLR family, pyrin domain containing 3

multiple interactions

[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of NLRP3 mRNA; [Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of NLRP3 protein; Berberine inhibits the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of NLRP3 mRNA]; Berberine inhibits the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of NLRP3 protein]

NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811

G

nitric oxide synthase 2

multiple interactions

[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of NOS2 mRNA; [Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of NOS2 protein; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of NOS2 mRNA]; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of NOS2 protein]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of NOS2 mRNA]]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of NOS2 protein]]; NG-Nitroarginine Methyl Ester inhibits the reaction [Arginine inhibits the reaction [Indomethacin results in increased expression of NOS2 mRNA]]; Particulate Matter inhibits the reaction [alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of NOS2 mRNA]]; Particulate Matter inhibits the reaction [alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of NOS2 protein]]; Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of NOS2 mRNA]; Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of NOS2 protein]

PMID:29423081 PMID:37483153

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

nitric oxide synthase 3

decreases expression
multiple interactions

NG-Nitroarginine Methyl Ester results in decreased expression of NOS3 protein
Sildenafil Citrate inhibits the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of NOS3 protein]; tangeretin inhibits the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of NOS3 protein]
[Folic Acid co-treated with NG-Nitroarginine Methyl Ester] results in decreased expression of NOS3 protein

PMID:28624453 PMID:32479886

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

natriuretic peptide A

increases expression

NG-Nitroarginine Methyl Ester results in increased expression of NPPA mRNA

NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351

G

natriuretic peptide B

increases expression

NG-Nitroarginine Methyl Ester results in increased expression of NPPB mRNA

NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168

G

oxoglutarate dehydrogenase

decreases activity
multiple interactions

NG-Nitroarginine Methyl Ester results in decreased activity of OGDH protein
bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in decreased activity of OGDH protein]

PMID:37718616 PMID:38029875

NCBI chr14:81,150,021...81,217,479
Ensembl chr14:81,150,091...81,217,479

G

pannexin 3

multiple interactions

NG-Nitroarginine Methyl Ester inhibits the reaction [2-chloroethyl ethyl sulfide results in decreased expression of PANX3 mRNA]

NCBI chr 8:37,366,758...37,377,640
Ensembl chr 8:37,366,862...37,377,640

G

poly (ADP-ribose) polymerase 1

multiple interactions

NG-Nitroarginine Methyl Ester inhibits the reaction [AGT protein results in increased activity of PARP1 protein]

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

phosphodiesterase 5A

increases activity
multiple interactions

NG-Nitroarginine Methyl Ester results in increased activity of PDE5A protein
[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of PDE5A protein; bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased activity of PDE5A protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of PDE5A protein]; naringin inhibits the reaction [bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased activity of PDE5A protein]]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester promotes the reaction [bisphenol A results in increased activity of PDE5A protein]]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased activity of PDE5A protein]; NG-Nitroarginine Methyl Ester promotes the reaction [bisphenol A results in increased activity of PDE5A protein]

PMID:32172062 PMID:32428650 PMID:32810514

NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701

G

peroxisome proliferator-activated receptor gamma

multiple interactions
decreases expression

ALKBH5 protein promotes the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of PPARG protein]

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

prostaglandin-endoperoxide synthase 2

multiple interactions

NG-Nitroarginine Methyl Ester inhibits the reaction [Folic Acid inhibits the reaction [cobaltous chloride results in increased expression of PTGS2 mRNA]]; NG-Nitroarginine Methyl Ester inhibits the reaction [Folic Acid inhibits the reaction [cobaltous chloride results in increased expression of PTGS2 protein]]
NG-Nitroarginine Methyl Ester inhibits the reaction [Arginine inhibits the reaction [Indomethacin results in increased expression of PTGS2 mRNA]]

PMID:28624453 PMID:37483153

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

PYD and CARD domain containing

multiple interactions

[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of PYCARD mRNA; Berberine inhibits the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of PYCARD mRNA]

NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955

G

receptor activity modifying protein 2

increases expression

NG-Nitroarginine Methyl Ester results in increased expression of RAMP2 mRNA

NCBI chr10:86,187,366...86,190,692
Ensembl chr10:86,188,812...86,231,829

G

receptor activity modifying protein 3

increases expression

NG-Nitroarginine Methyl Ester results in increased expression of RAMP3 mRNA

NCBI chr14:81,527,404...81,544,905
Ensembl chr14:81,527,385...81,544,902

G

succinate dehydrogenase complex flavoprotein subunit A

multiple interactions
decreases activity

bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in decreased activity of SDHA protein]

NCBI chr 1:28,935,965...28,960,936
Ensembl chr 1:28,940,164...28,961,535

G

SET domain containing 2, histone lysine methyltransferase

decreases expression

NG-Nitroarginine Methyl Ester results in decreased expression of SETD2 mRNA alternative form

NCBI chr 8:110,511,808...110,597,475
Ensembl chr 8:110,511,772...110,597,489

G

SMAD family member 2

multiple interactions

[Huang Qi co-treated with Coptidis rhizoma extract co-treated with Aconitic Acid co-treated with Centella asiatica extract] inhibits the reaction [[Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased phosphorylation of SMAD2 protein]; [Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased phosphorylation of SMAD2 protein

NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323

G

SMAD family member 3

multiple interactions

[Huang Qi co-treated with Coptidis rhizoma extract co-treated with Aconitic Acid co-treated with Centella asiatica extract] inhibits the reaction [[Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased phosphorylation of SMAD3 protein]; [Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased phosphorylation of SMAD3 protein

NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960

G

superoxide dismutase 1

multiple interactions
decreases activity

bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in decreased activity of SOD1 protein]

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

sialophorin

multiple interactions
increases expression

[NG-Nitroarginine Methyl Ester co-treated with bisphenol A co-treated with naringin] results in decreased expression of SPN protein; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of SPN protein; [NG-Nitroarginine Methyl Ester co-treated with naringin] results in decreased expression of SPN protein; bisphenol A inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of SPN protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of SPN protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of SPN protein]

PMID:32172062 PMID:32428650

NCBI chr 1:181,746,937...181,759,564
Ensembl chr 1:181,746,429...181,759,628

G

sequestosome 1

multiple interactions

[Berberine co-treated with Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of SQSTM1 protein

NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673

G

steroidogenic acute regulatory protein

multiple interactions
decreases expression

Sildenafil Citrate inhibits the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of STAR protein]; tangeretin inhibits the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of STAR protein]

NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672

G

thromboxane A2 receptor

increases expression

NG-Nitroarginine Methyl Ester results in increased expression of TBXA2R mRNA

NCBI chr 7:8,383,347...8,390,753
Ensembl chr 7:8,383,378...8,388,176

G

transforming growth factor, beta 1

multiple interactions

[Huang Qi co-treated with Coptidis rhizoma extract co-treated with Aconitic Acid co-treated with Centella asiatica extract] inhibits the reaction [[Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TGFB1 protein]; [Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TGFB1 protein

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

tyrosine hydroxylase

decreases expression

NG-Nitroarginine Methyl Ester results in decreased expression of TH protein

NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767

G

tumor necrosis factor

multiple interactions
increases expression

[bisphenol A co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF protein; [Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF mRNA; [Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF protein; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of TNF protein; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF mRNA]; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF protein]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF mRNA]]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF protein]]; bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased expression of TNF mRNA]; bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased expression of TNF protein]; naringin inhibits the reaction [[bisphenol A co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of TNF protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of TNF protein]; NG-Nitroarginine Methyl Ester inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]; Particulate Matter inhibits the reaction [alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF protein]]; Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF mRNA]; Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF protein]
[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of TNF mRNA; Berberine inhibits the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of TNF mRNA]
[NG-Nitroarginine Methyl Ester co-treated with TNF protein] results in increased secretion of VWF protein
NG-Nitroarginine Methyl Ester results in increased expression of TNF mRNA; NG-Nitroarginine Methyl Ester results in increased expression of TNF protein

PMID:29423081 PMID:30529211 PMID:32172062 PMID:32428650 PMID:32810514 More...

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

tumor protein p53

increases expression
multiple interactions

NG-Nitroarginine Methyl Ester results in increased expression of TP53 protein
[bisphenol A co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TP53 protein; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of TP53 protein; [NG-Nitroarginine Methyl Ester co-treated with naringin] results in decreased expression of TP53 protein; bisphenol A inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of TP53 protein]; naringin inhibits the reaction [[bisphenol A co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TP53 protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of TP53 protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of TP53 protein]; NG-Nitroarginine Methyl Ester promotes the reaction [bisphenol A results in increased expression of TP53 protein]

PMID:32172062 PMID:32428650 PMID:32810514

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

transient receptor potential cation channel, subfamily A, member 1

decreases response to substance

TRPA1 gene mutant form results in decreased susceptibility to NG-Nitroarginine Methyl Ester

NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570

G

vascular cell adhesion molecule 1

multiple interactions

[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of VCAM1 mRNA; [Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of VCAM1 protein; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of VCAM1 mRNA]; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of VCAM1 protein]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of VCAM1 mRNA]]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of VCAM1 protein]]; Particulate Matter inhibits the reaction [alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of VCAM1 protein]]; Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of VCAM1 mRNA]; Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of VCAM1 protein]

NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958

G

vimentin

multiple interactions
decreases expression

ALKBH5 protein promotes the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of VIM protein]

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

G

von Willebrand factor

multiple interactions

[NG-Nitroarginine Methyl Ester co-treated with TNF protein] results in increased secretion of VWF protein

NCBI chr 4:158,360,152...158,491,539
Ensembl chr 4:158,360,152...158,491,539

G

Wnt family member 2

decreases expression
multiple interactions

NG-Nitroarginine Methyl Ester results in decreased expression of WNT2 protein
ALKBH5 protein promotes the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of WNT2 protein]

NCBI chr 4:46,328,408...46,374,673
Ensembl chr 4:46,333,998...46,374,402

oseltamivir

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

androgen receptor

multiple interactions

Oseltamivir binds to and results in decreased activity of AR protein; Oseltamivir binds to and results in increased activity of AR protein

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

carboxylesterase 1D

affects hydrolysis
increases metabolic processing
multiple interactions

CES1 protein affects the hydrolysis of Oseltamivir
CES1 protein results in increased metabolism of Oseltamivir
7,8-dihydromethysticin inhibits the reaction [[CES1 protein results in increased metabolism of Oseltamivir] which results in increased abundance of oseltamivir carboxylate]; [CES1 protein results in increased metabolism of Oseltamivir] which results in increased abundance of oseltamivir carboxylate; [hirsutine results in decreased activity of CES1 protein] which results in decreased metabolism of Oseltamivir; [mitragynine results in decreased activity of CES1 protein] which results in decreased metabolism of Oseltamivir; [paynantheine results in decreased activity of CES1 protein] which results in decreased metabolism of Oseltamivir; [Plant Extracts results in decreased activity of CES1 protein] which results in decreased metabolism of Oseltamivir; [speciogynine results in decreased activity of CES1 protein] which results in decreased metabolism of Oseltamivir; desmethoxyyangonin inhibits the reaction [[CES1 protein results in increased metabolism of Oseltamivir] which results in increased abundance of oseltamivir carboxylate]; dihydrokavain inhibits the reaction [[CES1 protein results in increased metabolism of Oseltamivir] which results in increased abundance of oseltamivir carboxylate]; kavain inhibits the reaction [[CES1 protein results in increased metabolism of Oseltamivir] which results in increased abundance of oseltamivir carboxylate]; methysticin inhibits the reaction [[CES1 protein results in increased metabolism of Oseltamivir] which results in increased abundance of oseltamivir carboxylate]; yangonin inhibits the reaction [[CES1 protein results in increased metabolism of Oseltamivir] which results in increased abundance of oseltamivir carboxylate]

PMID:18983829 PMID:35278473 PMID:37716419

NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035

G

interleukin 6

decreases response to substance

IL6 protein results in decreased susceptibility to Oseltamivir

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

progesterone receptor

multiple interactions

Oseltamivir binds to and results in increased activity of PGR protein

NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344

G

solute carrier family 7 member 11

decreases expression

Oseltamivir results in decreased expression of SLC7A11 mRNA

NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536

oxybuprocaine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

apoptosis inducing factor, mitochondria associated 1

increases expression

benoxinate results in increased expression of AIFM1 protein

NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256

G

BCL2 associated X, apoptosis regulator

increases expression

benoxinate results in increased expression of BAX protein

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

Bcl2-like 1

decreases expression

benoxinate results in decreased expression of BCL2L1 protein

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

G

caspase 2

increases activity

benoxinate results in increased activity of CASP2 protein

NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379

G

caspase 3

increases activity

benoxinate results in increased activity of CASP3 protein

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 9

increases activity

benoxinate results in increased activity of CASP9 protein

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

potassium voltage-gated channel subfamily H member 2

decreases activity

benoxinate results in decreased activity of KCNH2 protein

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

G

nuclear receptor subfamily 1, group I, member 2

increases activity

benoxinate results in increased activity of NR1I2 protein

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

solute carrier family 22 member 2

multiple interactions

benoxinate inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

perindopril

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensin I converting enzyme

affects response to substance

ACE gene polymorphism affects the susceptibility to Perindopril

NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131

G

angiotensin converting enzyme 2

multiple interactions

Perindopril promotes the reaction [Carbon Tetrachloride results in increased expression of ACE2 mRNA]; Perindopril promotes the reaction [Carbon Tetrachloride results in increased expression of ACE2 protein]

NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977

G

actin alpha 2, smooth muscle

decreases expression
multiple interactions

Perindopril results in decreased expression of ACTA2 protein
[Imatinib Mesylate co-treated with Perindopril] inhibits the reaction [Carbon Tetrachloride affects the expression of ACTA2 mRNA]; Perindopril inhibits the reaction [Carbon Tetrachloride affects the expression of ACTA2 mRNA]

PMID:12076858 PMID:16596278

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

alpha-fetoprotein

multiple interactions

Perindopril inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein]

NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480

G

angiotensinogen

decreases expression
increases expression
multiple interactions

Perindopril results in decreased expression of AGT protein alternative form
Perindopril results in increased expression of AGT protein alternative form
[Perindopril co-treated with racecadotril] results in increased expression of AGT protein alternative form; Perindopril inhibits the reaction [Methotrexate results in decreased expression of AGT protein alternative form]; Perindopril inhibits the reaction [Methotrexate results in increased expression of AGT protein]
Perindopril results in decreased expression of AGT protein; Perindopril results in decreased expression of AGT protein alternative form

PMID:2549899 PMID:2605800 PMID:9808682 PMID:34737150

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

angiotensin II receptor, type 1a

affects response to substance
multiple interactions

AGTR1 gene SNP affects the susceptibility to Perindopril
Perindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of AGTR1A mRNA]; Perindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of AGTR1A protein]
[Perindopril co-treated with AM6545] inhibits the reaction [Streptozocin results in increased expression of AGTR1A protein]; Perindopril inhibits the reaction [Streptozocin results in increased expression of AGTR1A mRNA]; Perindopril inhibits the reaction [Streptozocin results in increased expression of AGTR1A protein]

PMID:8952600 PMID:12930639 PMID:16097048 PMID:30184259

NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946

G

albumin

multiple interactions

Perindopril inhibits the reaction [Carbon Tetrachloride results in decreased expression of ALB protein]
Perindopril inhibits the reaction [Streptozocin results in increased expression of ALB protein]

PMID:16872305 PMID:30184259

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

arginase 1

multiple interactions

Perindopril inhibits the reaction [AM6545 inhibits the reaction [Streptozocin results in decreased expression of ARG1 mRNA]]

NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422

G

Bcl2-like 1

multiple interactions

Perindopril inhibits the reaction [Isoproterenol results in increased expression of BCL2L1 mRNA alternative form]

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

G

bradykinin receptor B1

affects expression

Perindopril affects the expression of BDKRB1 protein

NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747

G

bradykinin receptor B2

affects expression

Perindopril affects the expression of BDKRB2 protein

NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497

G

catalase

increases activity

Perindopril results in increased activity of CAT protein

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 2

decreases expression
multiple interactions

Perindopril results in decreased expression of CCL2 protein
[AM6545 co-treated with Perindopril] inhibits the reaction [Streptozocin results in increased expression of CCL2 mRNA]; [AM6545 co-treated with Perindopril] inhibits the reaction [Streptozocin results in increased expression of CCL2 protein]

PMID:19840533 PMID:30184259

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 3

multiple interactions

AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in increased expression of CCL3 mRNA]]; Perindopril inhibits the reaction [Streptozocin results in increased expression of CCL3 mRNA]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in increased expression of CCL3 mRNA]]

NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938

G

cyclin D1

multiple interactions

Perindopril inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 mRNA]

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

C-C motif chemokine receptor 2

multiple interactions

[AM6545 co-treated with Perindopril] inhibits the reaction [Streptozocin results in increased expression of CCR2 mRNA]; Perindopril inhibits the reaction [Streptozocin results in increased expression of CCR2 mRNA]

NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100

G

CD163 molecule

multiple interactions

AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in decreased expression of CD163 mRNA]]; Perindopril inhibits the reaction [Streptozocin results in decreased expression of CD163 mRNA]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in decreased expression of CD163 mRNA]]

NCBI chr 4:157,085,080...157,118,470
Ensembl chr 4:157,085,093...157,117,878

G

Cd68 molecule

multiple interactions

AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in increased expression of CD68 mRNA]]; Perindopril inhibits the reaction [Streptozocin results in increased expression of CD68 mRNA]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in increased expression of CD68 mRNA]]

NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697

G

collagen type I alpha 2 chain

multiple interactions

[Imatinib Mesylate co-treated with Perindopril] inhibits the reaction [Carbon Tetrachloride affects the expression of COL1A2 mRNA]; Perindopril inhibits the reaction [Carbon Tetrachloride affects the expression of COL1A2 mRNA]

NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867

G

collagen type III alpha 1 chain

decreases expression

Perindopril results in decreased expression of COL3A1 mRNA

PMID:12076858 PMID:14871039

NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547

G

fibronectin 1

multiple interactions

[AM6545 co-treated with Perindopril] inhibits the reaction [Streptozocin results in increased expression of FN1 mRNA]; Perindopril inhibits the reaction [Streptozocin results in increased expression of FN1 mRNA]; Perindopril inhibits the reaction [Streptozocin results in increased expression of FN1 protein]

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

Fos proto-oncogene, AP-1 transcription factor subunit

decreases expression
multiple interactions

Perindopril results in decreased expression of FOS protein
Perindopril inhibits the reaction [Methotrexate results in increased expression of FOS protein]

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

glutamic--pyruvic transaminase

multiple interactions

Perindopril inhibits the reaction [Diethylnitrosamine results in increased activity of GPT protein]

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

intercellular adhesion molecule 1

multiple interactions

AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in increased expression of ICAM1 mRNA]]; AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in increased expression of ICAM1 protein]]; Perindopril inhibits the reaction [Streptozocin results in increased expression of ICAM1 mRNA]; Perindopril inhibits the reaction [Streptozocin results in increased expression of ICAM1 protein]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in increased expression of ICAM1 mRNA]]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in increased expression of ICAM1 protein]]

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

interleukin 10

increases expression
multiple interactions

Perindopril results in increased expression of IL10 protein
Perindopril inhibits the reaction [Methotrexate results in decreased expression of IL10 protein]

PMID:19840533 PMID:34737150

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 1 beta

decreases expression
multiple interactions

Perindopril results in decreased expression of IL1B protein
Perindopril inhibits the reaction [Methotrexate results in increased expression of IL1B protein]

PMID:19840533 PMID:34737150

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

decreases expression
multiple interactions

Perindopril results in decreased expression of IL6 protein
Perindopril inhibits the reaction [Methotrexate results in increased expression of IL6 protein]

PMID:19840533 PMID:34737150

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

Perindopril inhibits the reaction [Methotrexate results in increased expression of JUN protein]

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

kininogen 1

decreases expression
multiple interactions
increases expression

Perindopril results in decreased expression of KNG1 protein modified form
Perindopril promotes the reaction [racecadotril affects the metabolism of KNG1 protein alternative form]
Perindopril results in increased expression of KNG1 protein alternative form

PMID:9808682 PMID:11855668

NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555

G

leptin

decreases expression

Perindopril results in decreased expression of LEP protein

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

G

MAS1 proto-oncogene, G protein-coupled receptor

multiple interactions

Perindopril promotes the reaction [Carbon Tetrachloride results in increased expression of MAS1 mRNA]

NCBI chr 1:47,879,956...47,911,500
Ensembl chr 1:47,880,309...47,911,709

G

mitofusin 2

increases expression

Perindopril results in increased expression of MFN2 mRNA; Perindopril results in increased expression of MFN2 protein

NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342

G

matrix metallopeptidase 2

multiple interactions

Perindopril inhibits the reaction [Carbon Tetrachloride results in increased activity of MMP2 protein]
Perindopril inhibits the reaction [Diethylnitrosamine results in increased expression of MMP2 protein]

PMID:12930639 PMID:14761280 PMID:16097048 PMID:29859236

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

multiple interactions

Perindopril inhibits the reaction [Carbon Tetrachloride results in increased activity of MMP9 protein]

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

mannose receptor, C type 1

multiple interactions

AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in decreased expression of MRC1 mRNA]]; Perindopril inhibits the reaction [Streptozocin results in decreased expression of MRC1 mRNA]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in decreased expression of MRC1 mRNA]]

NCBI chr17:77,249,187...77,330,857
Ensembl chr17:77,249,187...77,330,857

G

nuclear factor kappa B subunit 1

multiple interactions

Perindopril inhibits the reaction [Diethylnitrosamine results in decreased expression of NFKB1 protein]

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

nitric oxide synthase 2

multiple interactions

AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in increased expression of NOS2 mRNA]]; Perindopril inhibits the reaction [Streptozocin results in increased expression of NOS2 mRNA]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in increased expression of NOS2 mRNA]]

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

NPHS2 stomatin family member, podocin

multiple interactions

AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in decreased expression of NPHS2 mRNA]]; AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in decreased expression of NPHS2 protein]]; Perindopril inhibits the reaction [Streptozocin results in decreased expression of NPHS2 mRNA]; Perindopril inhibits the reaction [Streptozocin results in decreased expression of NPHS2 protein]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in decreased expression of NPHS2 mRNA]]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in decreased expression of NPHS2 protein]]

NCBI chr13:68,448,720...68,461,312
Ensembl chr13:68,448,926...68,461,313

G

platelet derived growth factor subunit B

multiple interactions

Perindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of [PDGFB protein binds to PDGFB protein]]; Perindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFB protein]

PMID:12930639 PMID:14761280 PMID:16097048

NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984

G

peroxisome proliferator-activated receptor gamma

multiple interactions
increases expression

Perindopril inhibits the reaction [Methotrexate results in decreased expression of PPARG mRNA]; Perindopril inhibits the reaction [Methotrexate results in decreased expression of PPARG protein]
Perindopril results in increased expression of PPARG mRNA; Perindopril results in increased expression of PPARG protein

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

protein phosphatase 3 catalytic subunit alpha

decreases expression

Perindopril results in decreased expression of PPP3CA protein

NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974

G

protein phosphatase 3, regulatory subunit B, alpha

decreases expression

Perindopril results in decreased expression of PPP3R1 mRNA

NCBI chr14:91,556,743...91,606,391
Ensembl chr14:91,604,121...91,606,907

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

Perindopril inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of RELA protein]
Perindopril inhibits the reaction [Methotrexate results in increased expression of RELA protein]

PMID:29859236 PMID:34737150

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

renin

increases expression
increases activity

Perindopril results in increased expression of REN protein
Perindopril results in increased activity of REN protein

PMID:2549899 PMID:2605800 PMID:9383173

NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489

G

ryanodine receptor 2

multiple interactions
increases expression

carvedilol promotes the reaction [Perindopril results in increased expression of RYR2 protein]; Perindopril promotes the reaction [carvedilol results in increased expression of RYR2 protein]

NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142

G

secreted frizzled-related protein 4

affects binding

Perindopril binds to SFRP4 protein

NCBI chr17:45,278,867...45,330,806
Ensembl chr17:45,234,097...45,330,736

G

sirtuin 1

multiple interactions
increases expression

Perindopril inhibits the reaction [Methotrexate results in decreased expression of SIRT1 mRNA]; Perindopril inhibits the reaction [Methotrexate results in decreased expression of SIRT1 protein]
Perindopril results in increased expression of SIRT1 mRNA; Perindopril results in increased expression of SIRT1 protein

NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260

G

solute carrier family 15 member 1

multiple interactions

Perindopril inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine]

NCBI chr15:98,537,641...98,582,544
Ensembl chr15:98,537,641...98,582,545

G

solute carrier family 15 member 2

multiple interactions

Perindopril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine]

NCBI chr11:64,014,182...64,043,228
Ensembl chr11:64,014,182...64,043,225

G

SMAD family member 3

multiple interactions
decreases expression

Perindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 protein]
Perindopril results in decreased expression of SMAD3 protein

PMID:15619341 PMID:16872305

NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960

G

SMAD family member 7

increases expression
multiple interactions

Perindopril results in increased expression of SMAD7 protein
Perindopril inhibits the reaction [Carbon Tetrachloride results in decreased expression of SMAD7 protein]

PMID:15619341 PMID:16872305

NCBI chr18:68,988,429...69,016,774
Ensembl chr18:68,988,429...69,016,765

G

transforming growth factor, beta 1

multiple interactions
decreases expression

Perindopril inhibits the reaction [Carbon Tetrachloride affects the expression of TGFB1 mRNA]; Perindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]; Perindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]
Perindopril inhibits the reaction [Diethylnitrosamine results in increased expression of TGFB1 protein]
Perindopril results in decreased expression of TGFB1 mRNA; Perindopril results in decreased expression of TGFB1 protein

PMID:12930639 PMID:14761280 PMID:14871039 PMID:15619341 PMID:16097048 More...

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

transforming growth factor, beta receptor 2

decreases expression
multiple interactions

Perindopril results in decreased expression of TGFBR2 mRNA
Perindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFBR2 mRNA]

PMID:15619341 PMID:16872305

NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228

G

toll-like receptor 4

multiple interactions

Perindopril inhibits the reaction [Methotrexate results in increased expression of TLR4 mRNA]; Perindopril inhibits the reaction [Methotrexate results in increased expression of TLR4 protein]

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

G

tumor necrosis factor

decreases expression
multiple interactions
increases expression

Perindopril results in decreased expression of TNF protein
Perindopril inhibits the reaction [Methotrexate results in increased expression of TNF protein]
AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in increased expression of TNF mRNA]]; AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in increased expression of TNF protein]]; Perindopril inhibits the reaction [Diethylnitrosamine results in increased expression of TNF protein]; Perindopril inhibits the reaction [Streptozocin results in increased expression of TNF mRNA]; Perindopril inhibits the reaction [Streptozocin results in increased expression of TNF protein]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in increased expression of TNF mRNA]]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in increased expression of TNF protein]]
Perindopril results in increased expression of TNF protein

PMID:19840533 PMID:26878793 PMID:29859236 PMID:30184259 PMID:34737150

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

vascular endothelial growth factor A

multiple interactions

Perindopril inhibits the reaction [Diethylnitrosamine results in increased expression of VEGFA protein]

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

von Willebrand factor

decreases expression

Perindopril results in decreased expression of VWF protein

NCBI chr 4:158,360,152...158,491,539
Ensembl chr 4:158,360,152...158,491,539

propacetamol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions

propacetamol results in increased expression of BAX protein
kaempferol inhibits the reaction [propacetamol results in increased expression of BAX protein]

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

caspase 3

increases cleavage
multiple interactions

propacetamol results in increased cleavage of CASP3 protein
kaempferol inhibits the reaction [propacetamol results in increased cleavage of CASP3 protein]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

catalase

decreases activity
multiple interactions

propacetamol results in decreased activity of CAT protein
kaempferol inhibits the reaction [propacetamol results in decreased activity of CAT protein]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cytochrome P450, family 2, subfamily e, polypeptide 1

increases expression
multiple interactions

propacetamol results in increased expression of CYP2E1 protein
kaempferol inhibits the reaction [propacetamol results in increased expression of CYP2E1 protein]

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

glutamate-cysteine ligase, catalytic subunit

affects expression
multiple interactions

propacetamol affects the expression of GCLC protein
kaempferol affects the reaction [propacetamol affects the expression of GCLC protein]

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

glutamic--pyruvic transaminase

multiple interactions
increases activity

kaempferol inhibits the reaction [propacetamol results in increased activity of GPT protein]

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

heme oxygenase 1

affects expression
multiple interactions

propacetamol affects the expression of HMOX1 protein
kaempferol affects the reaction [propacetamol affects the expression of HMOX1 protein]

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

interleukin 6

multiple interactions
increases expression

kaempferol inhibits the reaction [propacetamol results in increased expression of IL6 protein]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

mitogen activated protein kinase 1

multiple interactions
increases phosphorylation

kaempferol inhibits the reaction [propacetamol results in increased phosphorylation of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions
increases phosphorylation

kaempferol inhibits the reaction [propacetamol results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

NFE2 like bZIP transcription factor 2

affects expression
multiple interactions

propacetamol affects the expression of NFE2L2 protein
kaempferol affects the reaction [propacetamol affects the expression of NFE2L2 protein]

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

receptor interacting serine/threonine kinase 1

increases expression
multiple interactions

propacetamol results in increased expression of RIPK1 protein
kaempferol inhibits the reaction [propacetamol results in increased expression of RIPK1 protein]

NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824

G

tumor necrosis factor

increases expression
multiple interactions

propacetamol results in increased expression of TNF protein
kaempferol inhibits the reaction [propacetamol results in increased expression of TNF protein]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

UDP glucuronosyltransferase family 1 member A1

decreases expression
multiple interactions

propacetamol results in decreased expression of UGT1A1 protein
kaempferol inhibits the reaction [propacetamol results in decreased expression of UGT1A1 protein]

NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465

remifentanil

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

caspase 3

multiple interactions

[Antagomirs results in decreased expression of MIR205 mRNA] promotes the reaction [Remifentanil inhibits the reaction [[Oxygen co-treated with Dithionite] results in increased expression of CASP3 protein modified form]]; [Antagomirs results in decreased expression of MIR205 mRNA] promotes the reaction [Remifentanil inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of CASP3 protein modified form]]; MIR205 mRNA inhibits the reaction [Remifentanil inhibits the reaction [[Oxygen co-treated with Dithionite] results in increased expression of CASP3 protein modified form]]; Remifentanil inhibits the reaction [[Oxygen co-treated with Dithionite] results in increased expression of CASP3 protein modified form]; Remifentanil inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of CASP3 protein modified form]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

glutamate ionotropic receptor NMDA type subunit 2B

multiple interactions
increases phosphorylation

Ketamine inhibits the reaction [remifentanil results in increased phosphorylation of GRIN2B protein]

NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279

G

5-hydroxytryptamine receptor 3A

affects activity

remifentanil affects the activity of HTR3A protein

NCBI chr 8:49,242,018...49,254,475
Ensembl chr 8:49,242,020...49,254,389

G

microRNA 205

multiple interactions

[Antagomirs results in decreased expression of MIR205 mRNA] promotes the reaction [Remifentanil inhibits the reaction [[Oxygen co-treated with Dithionite] results in increased expression of CASP3 protein modified form]]; [Antagomirs results in decreased expression of MIR205 mRNA] promotes the reaction [Remifentanil inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of PINK1 protein]]; [Antagomirs results in decreased expression of MIR205 mRNA] promotes the reaction [Remifentanil inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of CASP3 protein modified form]]; [Antagomirs results in decreased expression of MIR205 mRNA] promotes the reaction [Remifentanil inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MIR205 mRNA]]; [Antagomirs results in decreased expression of MIR205 mRNA] which results in increased susceptibility to Remifentanil; MIR205 mRNA inhibits the reaction [Remifentanil inhibits the reaction [[Oxygen co-treated with Dithionite] results in increased expression of CASP3 protein modified form]]; Remifentanil inhibits the reaction [[Oxygen co-treated with Dithionite] results in increased expression of MIR205 mRNA]; Remifentanil inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MIR205 mRNA]

NCBI chr13:105,035,878...105,035,985
Ensembl chr13:105,035,878...105,035,985

G

PTEN induced kinase 1

multiple interactions

[Antagomirs results in decreased expression of MIR205 mRNA] promotes the reaction [Remifentanil inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of PINK1 protein]]; Remifentanil inhibits the reaction [[Oxygen co-treated with Dithionite] results in decreased expression of PINK1 protein]; Remifentanil inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of PINK1 protein]

NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635

G

protein kinase C, gamma

multiple interactions
affects localization

Lidocaine inhibits the reaction [remifentanil affects the localization of PRKCG protein]

NCBI chr 1:65,832,851...65,860,676
Ensembl chr 1:65,832,855...65,859,384

sofosbuvir

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

killer cell lectin like receptor C1

decreases expression

sofosbuvir co-treated with ledipasvir decreased expression of NCR1 protein in natural killer cells

RGD

NCBI chr 4:163,142,142...163,152,425
Ensembl chr 4:163,147,189...163,152,425

G

natural cytotoxicity triggering receptor 1

affects expression

sofosbuvir co-treated with ledipasvir affects expression of NCR1 protein in natural killer cells

RGD

NCBI chr 1:69,614,744...69,622,594
Ensembl chr 1:69,616,601...69,660,558

Valilactone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

fatty acid synthase

decreases activity

valilactone results in decreased activity of FASN protein

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19874
chemical entity	19872
group	19825
inorganic group	19404
oxo group	18908
organic oxo compound	18908
carbonyl compound	18908
carboxylic ester	16741
amino-acid ester	429
alpha-amino acid ester +	287
beta-amino acid ester +	147
butamben +	5
delta-amino acid ester +	0
ethyl 2-(dimethylamino)-1-phenylcyclohex-3-ene-1-carboxylate +	0
ethyl 4-chloro-2-(methylsulfanyl)hexahydropyrimidine-5-carboxylate	0
methyl 4-aminobutanoate	0
oseltamivir +	5
oxybuprocaine +	9
Path 2
Term	Annotations
CHEBI ontology	19874
subatomic particle	19872
composite particle	19872
hadron	19872
baryon	19872
nucleon	19872
atomic nucleus	19872
atom	19872
main group element atom	19811
p-block element atom	19811
carbon group element atom	19751
carbon atom	19748
organic molecular entity	19748
heteroorganic entity	19505
organochalcogen compound	19268
organooxygen compound	19184
ester	17455
carboxylic ester	16741
amino-acid ester	429
alpha-amino acid ester +	287
beta-amino acid ester +	147
butamben +	5
delta-amino acid ester +	0
ethyl 2-(dimethylamino)-1-phenylcyclohex-3-ene-1-carboxylate +	0
ethyl 4-chloro-2-(methylsulfanyl)hexahydropyrimidine-5-carboxylate	0
methyl 4-aminobutanoate	0
oseltamivir +	5
oxybuprocaine +	9

paths to the root