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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:carbapenems
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Accession:CHEBI:46633 term browser browse the term
Definition:The class of beta-lactam antibiotics that whose members have a carbapenem skeleton which is variously substituted at positions 3, 4, and 6.
Synonyms:related_synonym: Formula=C7H4NO3R3;   SMILES=[H][C@@]12C([*])C(=O)N1C(C(O)=O)=C([*])C2[*]
 xref_mesh: MESH:D015780
 xref: PMID:18076336;   PMID:19199922;   PMID:19610642;   PMID:19617229;   PMID:19929840;   PMID:21859938;   Wikipedia:Carbapenem


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carbapenems term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apeh acylaminoacyl-peptide hydrolase multiple interactions
decreases activity		 ISO Carbapenems inhibits the reaction [APEH protein results in increased metabolism of valproic acid glucuronide]
Carbapenems results in decreased activity of APEH protein		 CTD PMID:20551238 NCBI chr 8:108,773,791...108,782,903
Ensembl chr 8:108,773,794...108,782,933 		JBrowse link
imipenem hydrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions ISO [Vancomycin co-treated with Imipenem] results in increased expression of ABCB11 mRNA CTD PMID:24657338 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO [Vancomycin co-treated with Imipenem] results in decreased expression of ABCB1A mRNA CTD PMID:24657338 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO [Vancomycin co-treated with Imipenem] affects the expression of ABCC2 mRNA CTD PMID:24657338 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions ISO [Vancomycin co-treated with Imipenem] results in decreased expression of ABCC3 mRNA CTD PMID:24657338 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 multiple interactions ISO [Vancomycin co-treated with Imipenem] affects the expression of ABCG5 mRNA CTD PMID:24657338 NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563 		JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 multiple interactions ISO [Vancomycin co-treated with Imipenem] affects the expression of ABCG8 mRNA CTD PMID:24657338 NCBI chr 6:9,945,629...9,964,912
Ensembl chr 6:9,945,629...9,964,912 		JBrowse link
G Baat bile acid CoA:amino acid N-acyltransferase multiple interactions ISO [Vancomycin co-treated with Imipenem] results in decreased expression of BAAT mRNA CTD PMID:24657338 NCBI chr 5:63,851,668...63,860,641
Ensembl chr 5:63,850,705...63,860,685 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions ISO [Vancomycin co-treated with Imipenem] results in decreased expression of CYP7A1 mRNA CTD PMID:24657338 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688 		JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 multiple interactions ISO [Vancomycin co-treated with Imipenem] results in decreased expression of CYP8B1 mRNA CTD PMID:24657338 NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166 		JBrowse link
G Npc1l1 NPC1 like intracellular cholesterol transporter 1 multiple interactions ISO [Vancomycin co-treated with Imipenem] results in decreased expression of NPC1L1 mRNA CTD PMID:24657338 NCBI chr14:81,071,448...81,091,113
Ensembl chr14:81,071,451...81,091,113 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 multiple interactions ISO [Vancomycin co-treated with Imipenem] results in increased expression of NR0B2 mRNA CTD PMID:24657338 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Imipenem results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr5a2 nuclear receptor subfamily 5, group A, member 2 multiple interactions ISO [Vancomycin co-treated with Imipenem] results in increased expression of NR5A2 mRNA CTD PMID:24657338 NCBI chr13:48,313,634...48,433,494
Ensembl chr13:48,316,301...48,433,326 		JBrowse link
G Slc10a1 solute carrier family 10 member 1 multiple interactions ISO [Vancomycin co-treated with Imipenem] results in increased expression of SLC10A1 mRNA CTD PMID:24657338 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670 		JBrowse link
G Slc27a5 solute carrier family 27 member 5 multiple interactions ISO [Vancomycin co-treated with Imipenem] results in increased expression of SLC27A5 mRNA CTD PMID:24657338 NCBI chr 1:73,616,556...73,627,149
Ensembl chr 1:73,616,564...73,627,172 		JBrowse link
G Slc51a solute carrier family 51 member A multiple interactions ISO [Vancomycin co-treated with Imipenem] results in decreased expression of SLC51A mRNA CTD PMID:24657338 NCBI chr11:68,299,086...68,313,485
Ensembl chr11:68,299,086...68,313,485 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 multiple interactions ISO [Vancomycin co-treated with Imipenem] results in decreased expression of SLCO1A4 mRNA CTD PMID:24657338 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions ISO [Vancomycin co-treated with Imipenem] results in increased expression of SLCO1B2 mRNA CTD PMID:24657338 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981 		JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 multiple interactions ISO [Vancomycin co-treated with Imipenem] results in increased expression of SLCO2B1 mRNA CTD PMID:24657338 NCBI chr 1:153,959,288...154,007,294
Ensembl chr 1:153,959,293...154,007,353 		JBrowse link
meropenem term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RT1-DOb RT1 class II, locus DOb affects expression ISO meropenem affects the expression of HLA-DOB mRNA CTD PMID:25811541 NCBI chr20:4,619,418...4,625,627
Ensembl chr20:4,619,816...4,625,667 		JBrowse link
G RT1-M3-1 RT1 class Ib, locus M3, gene 1 affects expression ISO Meropenem affects the expression of HLA-G mRNA CTD PMID:25811541 NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      biological role 19842
        antimicrobial agent 18240
          antibacterial agent 16364
            carbapenems 22
              (4R,5S,6R)-3-[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid 0
              (5R,6R)-3-[2-(aminomethylideneamino)ethylthio]-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid 0
              17927 D 0
              1beta-methylcarbapenem 0
              2,3-Dihydrothienamycin 0
              3-[5-(Dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid 0
              8-epi-thienamycin 0
              Asparenomycin A 0
              Asparenomycin B 0
              Asparenomycin C 0
              BO 2727 0
              C-19393 E5 0
              Carbapenem biosynthesis intermediate 6 0
              Carpetimycin A 0
              Carpetimycin B 0
              Carpetimycin C 0
              Carpetimycin D 0
              Deacetylepithienamycin F 0
              Doripenem hydrate 0
              Epithienamycin A 0
              Epithienamycin B 0
              Epithienamycin C 0
              Epithienamycin F 0
              Ertapenem Disodium 0
              MK826 0
              MM 4550 0
              Meropenem sodium carbonate 0
              N-Acetylthienamycin 0
              NS-5 0
              Northienamycin 0
              OA-6129 A 0
              OA-6129 B1 0
              OA-6129 B2 0
              OA-6129 C 0
              OA-6129 D 0
              OA-6129 E 0
              PS-5 0
              PS-6 0
              PS-7 0
              PS-8 0
              Proteinase K 0
              SM-17466 0
              Thienamycin 0
              biapenem 0
              carbapenem + 0
              carbapenemcarboxylic acid + 2
              doripenem 0
              epithienamycin E 0
              imipenem + 19
              imipenem hydrate 19
              tebipenem pivoxil 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      carbon group element atom 19751
                        carbon atom 19748
                          organic molecular entity 19748
                            heteroorganic entity 19505
                              organochalcogen compound 19268
                                organooxygen compound 19184
                                  carbon oxoacid 18654
                                    carboxylic acid 18651
                                      carboacyl group 17694
                                        univalent carboacyl group 17694
                                          carbamoyl group 17545
                                            carboxamide 17545
                                              lactam 8389
                                                beta-lactam 828
                                                  beta-lactam antibiotic 813
                                                    carbapenems 22
                                                      (4R,5S,6R)-3-[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid 0
                                                      (5R,6R)-3-[2-(aminomethylideneamino)ethylthio]-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid 0
                                                      17927 D 0
                                                      1beta-methylcarbapenem 0
                                                      2,3-Dihydrothienamycin 0
                                                      3-[5-(Dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid 0
                                                      8-epi-thienamycin 0
                                                      Asparenomycin A 0
                                                      Asparenomycin B 0
                                                      Asparenomycin C 0
                                                      BO 2727 0
                                                      C-19393 E5 0
                                                      Carbapenem biosynthesis intermediate 6 0
                                                      Carpetimycin A 0
                                                      Carpetimycin B 0
                                                      Carpetimycin C 0
                                                      Carpetimycin D 0
                                                      Deacetylepithienamycin F 0
                                                      Doripenem hydrate 0
                                                      Epithienamycin A 0
                                                      Epithienamycin B 0
                                                      Epithienamycin C 0
                                                      Epithienamycin F 0
                                                      Ertapenem Disodium 0
                                                      MK826 0
                                                      MM 4550 0
                                                      Meropenem sodium carbonate 0
                                                      N-Acetylthienamycin 0
                                                      NS-5 0
                                                      Northienamycin 0
                                                      OA-6129 A 0
                                                      OA-6129 B1 0
                                                      OA-6129 B2 0
                                                      OA-6129 C 0
                                                      OA-6129 D 0
                                                      OA-6129 E 0
                                                      PS-5 0
                                                      PS-6 0
                                                      PS-7 0
                                                      PS-8 0
                                                      Proteinase K 0
                                                      SM-17466 0
                                                      Thienamycin 0
                                                      biapenem 0
                                                      carbapenem + 0
                                                      carbapenemcarboxylic acid + 2
                                                      doripenem 0
                                                      epithienamycin E 0
                                                      imipenem + 19
                                                      imipenem hydrate 19
                                                      tebipenem pivoxil 0
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