CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: disulfiram
Accession: CHEBI:4659
browse the term
Definition: An organic disulfide that results from the formal oxidative dimerisation of N,N-diethyldithiocarbamic acid. A multi-enzyme inhibitor that is used in alcohol aversion therapy and also exhibits anticancer properties.
Synonyms: exact_synonym: 1,1',1'',1'''-[disulfanediylbis(carbonothioylnitrilo)]tetraethane
related_synonym: 1,1'-dithiobis(N,N-diethylthioformamide); Antabuse; Formula=C10H20N2S4; InChI=1S/C10H20N2S4/c1-5-11(6-2)9(13)15-16-10(14)12(7-3)8-4/h5-8H2,1-4H3; InChIKey=AUZONCFQVSMFAP-UHFFFAOYSA-N; N,N,N',N'-tetraethylthiuram disulfide; SMILES=S(SC(N(CC)CC)=S)C(N(CC)CC)=S; bis(diethylthiocarbamoyl) disulfide; tetraethylthioperoxydicarbonic diamide; tetraethylthiuram disulfide; tetraethylthiuram disulphide
xref: CAS:97-77-8; DrugBank:DB00822; Drug_Central:928; HMDB:HMDB0014960; KEGG:C01692; KEGG:D00131; LINCS:LSM-5467
xref_mesh: MESH:D004221
xref: MetaCyc:DISULFIRAM; PMID:10841824; PMID:11005259; PMID:11716515; PMID:14978246; PMID:15325261; PMID:15709459; PMID:16426571; PMID:16661923; PMID:16666414; PMID:16880974; PMID:17079463; PMID:17579916; PMID:17667894; PMID:18579431; PMID:19720750; PMID:19782464; PMID:19787200; PMID:21471244; PMID:24496638; PMID:25133664; PMID:25445071; PMID:25464072; PMID:25476326; PMID:25495604; PMID:25557293; PMID:25565438; PMID:25657800; PMID:25777347; PMID:26033731; PMID:26224731; PMID:26235918; PMID:26239994; PMID:26314552; PMID:26517513; PMID:26550292; PMID:31151194; PMID:32963852; PMID:32971817; PMID:33731397; PMID:34012274; PMID:34045896; PMID:8442800; PMID:8572926; Pesticides:disulfiram; Reaxys:1712560; Wikipedia:Disulfiram
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Aars1
alanyl-tRNA synthetase 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of AARS1 mRNA
CTD
PMID:24690739
NCBI chr19:38,999,130...39,021,152
Ensembl chr19:38,999,163...39,021,147
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Abat
4-aminobutyrate aminotransferase
multiple interactions
EXP
[Ethanol co-treated with Disulfiram] results in decreased activity of ABAT protein; [Ethanol co-treated with Disulfiram] results in decreased expression of ABAT mRNA
CTD
PMID:9591243
NCBI chr10:6,996,688...7,092,835
Ensembl chr10:6,999,819...7,092,835
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Abca1
ATP binding cassette subfamily A member 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of ABCA1 mRNA
CTD
PMID:24690739
NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
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Abca3
ATP binding cassette subfamily A member 3
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of ABCA3 mRNA
CTD
PMID:24690739
NCBI chr10:13,382,439...13,439,748
Ensembl chr10:13,382,540...13,439,745
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Abcb11
ATP binding cassette subfamily B member 11
decreases activity multiple interactions
ISO
Disulfiram results in decreased activity of ABCB11 protein Disulfiram inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
CTD
PMID:24014644
NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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Abcb1a
ATP binding cassette subfamily B member 1A
multiple interactions decreases activity
ISO
Disulfiram affects the reaction [ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate]; Disulfiram inhibits the reaction [8-azidoadenosine 5'-triphosphate binds to ABCB1 protein]; Disulfiram inhibits the reaction [azidopine binds to ABCB1 protein]; Disulfiram inhibits the reaction [azidoprazosin binds to ABCB1 protein] Disulfiram metabolite results in decreased activity of ABCB1 protein; Disulfiram results in decreased activity of ABCB1 protein
CTD
PMID:10841824 PMID:14978246 PMID:16028354
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Abcc1
ATP binding cassette subfamily C member 1
decreases activity multiple interactions
ISO
Disulfiram results in decreased activity of ABCC1 protein Disulfiram affects the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; Disulfiram inhibits the reaction [8-azidoadenosine 5'-triphosphate binds to ABCC1 protein]
CTD
PMID:14978246
NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
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Abcc4
ATP binding cassette subfamily C member 4
multiple interactions
ISO
Disulfiram inhibits the reaction [8-azidoadenosine 5'-triphosphate binds to ABCC4 protein]; Disulfiram inhibits the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]
CTD
PMID:14978246
NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
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Abcg1
ATP binding cassette subfamily G member 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of ABCG1 mRNA
CTD
PMID:24690739
NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948
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Acad11
acyl-CoA dehydrogenase family, member 11
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of ACAD11 mRNA
CTD
PMID:24690739
NCBI chr 8:104,681,346...104,746,559
Ensembl chr 8:104,681,396...104,746,560
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Ace2
angiotensin converting enzyme 2
decreases expression
ISO
Disulfiram results in decreased expression of ACE2 mRNA
CTD
PMID:32808185
NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977
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Ache
acetylcholinesterase
decreases expression
EXP
Disulfiram results in decreased expression of ACHE protein
CTD
PMID:3868355
NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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Acss2
acyl-CoA synthetase short-chain family member 2
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of ACSS2 mRNA
CTD
PMID:24690739
NCBI chr 3:144,003,808...144,047,452
Ensembl chr 3:144,004,336...144,059,675
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Acta2
actin alpha 2, smooth muscle
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of ACTA2 mRNA
CTD
PMID:24690739
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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Adam9
ADAM metallopeptidase domain 9
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of ADAM9 mRNA
CTD
PMID:24690739
NCBI chr16:67,022,538...67,101,647
Ensembl chr16:67,022,655...67,100,917
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Adamts1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of ADAMTS1 mRNA
CTD
PMID:24690739
NCBI chr11:24,932,227...24,941,068
Ensembl chr11:24,931,761...24,941,103
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Adarb1
adenosine deaminase, RNA-specific, B1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of ADARB1 mRNA
CTD
PMID:24690739
NCBI chr20:11,222,569...11,350,854
Ensembl chr20:11,222,583...11,350,852
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Adcy3
adenylate cyclase 3
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of ADCY3 mRNA
CTD
PMID:24690739
NCBI chr 6:27,100,089...27,203,686
Ensembl chr 6:27,124,828...27,203,686
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Adgre5
adhesion G protein-coupled receptor E5
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of ADGRE5 mRNA
CTD
PMID:24690739
NCBI chr19:24,397,972...24,418,648
Ensembl chr19:24,398,689...24,418,638
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Adh1c
alcohol dehydrogenase 1C (class I), gamma polypeptide
decreases activity
EXP
Disulfiram results in decreased activity of ADH1 protein
CTD
PMID:15551062
NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892
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Adm
adrenomedullin
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of ADM mRNA
CTD
PMID:24690739
NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654
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Afap1
actin filament associated protein 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of AFAP1 mRNA
CTD
PMID:24690739
NCBI chr14:74,743,322...74,856,300
Ensembl chr14:74,743,320...74,856,263
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Agxt
alanine--glyoxylate aminotransferase
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of AGXT mRNA
CTD
PMID:24690739
NCBI chr 9:93,675,384...93,685,337
Ensembl chr 9:93,675,384...93,685,336
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Agxt2
alanine-glyoxylate aminotransferase 2
multiple interactions
EXP
[Ethanol co-treated with Disulfiram] results in decreased activity of AGXT2 protein
CTD
PMID:9591243
NCBI chr 2:59,336,252...59,377,664
Ensembl chr 2:59,336,283...59,377,926
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Ahsa1
activator of Hsp90 ATPase activity 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of AHSA1 mRNA
CTD
PMID:24690739
NCBI chr 6:106,913,296...106,921,347
Ensembl chr 6:106,913,530...106,921,345
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Akr1b1
aldo-keto reductase family 1 member B1
increases expression
ISO
Disulfiram results in increased expression of AKR1B1 mRNA
CTD
PMID:20566472
NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
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Akr1b10
aldo-keto reductase family 1 member B10
increases expression
ISO
Disulfiram results in increased expression of AKR1B10 mRNA
CTD
PMID:20566472
NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
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Akr1c1
aldo-keto reductase family 1, member C1
increases expression
ISO
Disulfiram results in increased expression of AKR1C1 mRNA
CTD
PMID:20566472
NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
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Akr1c3
aldo-keto reductase family 1, member C3
increases expression
ISO
Disulfiram results in increased expression of AKR1C3 mRNA
CTD
PMID:20566472
NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
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Akt1
AKT serine/threonine kinase 1
decreases phosphorylation
ISO
Disulfiram results in decreased phosphorylation of AKT1 protein
CTD
PMID:34182011
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Alad
aminolevulinate dehydratase
multiple interactions
EXP
[Disulfiram co-treated with Lead] results in decreased activity of ALAD protein
CTD
PMID:2748540
NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474
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Aldh1a1
aldehyde dehydrogenase 1 family, member A1
decreases activity multiple interactions decreases expression
EXP ISO
Disulfiram results in decreased activity of ALDH1A1 protein Disulfiram inhibits the reaction [ALDH1A1 protein results in decreased susceptibility to maphosphamide] Disulfiram results in decreased expression of ALDH1A1 mRNA; Disulfiram results in decreased expression of ALDH1A1 protein
CTD
PMID:8562935 PMID:10998257 PMID:21035945 PMID:34242567
NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
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Aldh1a2
aldehyde dehydrogenase 1 family, member A2
decreases activity
ISO
Disulfiram results in decreased activity of ALDH1A2 protein
CTD
PMID:22079344
NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107
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Aldh2
aldehyde dehydrogenase 2 family member
decreases activity multiple interactions decreases expression
ISO EXP
Disulfiram metabolite results in decreased activity of ALDH2 protein; Disulfiram results in decreased activity of ALDH2 protein [Disulfiram results in decreased activity of ALDH2 protein] which results in increased susceptibility to Glyceraldehyde; [Disulfiram results in decreased activity of ALDH2 protein] which results in increased susceptibility to glycolaldehyde; [Disulfiram results in decreased activity of ALDH2 protein] which results in increased susceptibility to Glyoxal; [Disulfiram results in decreased activity of ALDH2 protein] which results in increased susceptibility to hydroxypyruvic acid; [Disulfiram results in decreased activity of ALDH2 protein] which results in increased susceptibility to Pyruvaldehyde Disulfiram results in decreased expression of ALDH2 mRNA
CTD
PMID:9585485 PMID:10513990 PMID:11142365 PMID:21334317 PMID:21376711 PMID:22079344 PMID:24496638 More...
NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521
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Aldh3a1
aldehyde dehydrogenase 3 family, member A1
increases metabolic processing
ISO
ALDH3A1 protein results in increased metabolism of Disulfiram
CTD
PMID:18591790
NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681
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Angptl4
angiopoietin-like 4
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of ANGPTL4 mRNA
CTD
PMID:24690739
NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519
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Ano6
anoctamin 6
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of ANO6 mRNA
CTD
PMID:24690739
NCBI chr 7:126,933,919...127,113,588
Ensembl chr 7:126,933,936...127,113,589
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Apaf1
apoptotic peptidase activating factor 1
increases expression
ISO
Disulfiram results in increased expression of APAF1 mRNA
CTD
PMID:34182011
NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
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Apbb3
amyloid beta precursor protein binding family B member 3
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of APBB3 mRNA
CTD
PMID:24690739
NCBI chr18:28,273,168...28,280,347
Ensembl chr18:28,270,545...28,280,094
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Apcdd1l
APC down-regulated 1 like
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of APCDD1L mRNA
CTD
PMID:24690739
NCBI chr 3:162,587,484...162,658,362
Ensembl chr 3:162,582,252...162,658,073
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App
amyloid beta precursor protein
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of APP mRNA
CTD
PMID:24690739
NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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Ar
androgen receptor
multiple interactions
ISO
[Disulfiram co-treated with cupric chloride] results in decreased expression of AR protein; Disulfiram inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]
CTD
PMID:19789329 PMID:33049310
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Arc
activity-regulated cytoskeleton-associated protein
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of ARC mRNA
CTD
PMID:24690739
NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378
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Asgr1
asialoglycoprotein receptor 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of ASGR1 mRNA
CTD
PMID:24690739
NCBI chr10:54,775,727...54,779,642
Ensembl chr10:54,776,024...54,779,631
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Asmtl
acetylserotonin O-methyltransferase-like
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of ASMTL mRNA
CTD
PMID:24690739
NCBI chr12:16,315,335...16,318,083
Ensembl chr12:16,315,414...16,318,080
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Asns
asparagine synthetase (glutamine-hydrolyzing)
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of ASNS mRNA
CTD
PMID:24690739
NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423
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Atf1
activating transcription factor 1
multiple interactions
ISO
[Disulfiram co-treated with Copper] results in decreased activity of ATF1 protein; Copper promotes the reaction [Disulfiram results in decreased activity of ATF1 protein]
CTD
PMID:15367699
NCBI chr 7:131,361,962...131,404,677
Ensembl chr 7:131,362,450...131,404,670
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Atf2
activating transcription factor 2
multiple interactions
ISO
[Disulfiram co-treated with Copper] results in decreased activity of ATF2 protein; Copper promotes the reaction [Disulfiram results in decreased activity of ATF2 protein]
CTD
PMID:15367699
NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236
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Atf3
activating transcription factor 3
multiple interactions increases expression
ISO
[Disulfiram binds to Copper] which results in decreased expression of ATF3 mRNA; MTF1 protein affects the reaction [Disulfiram results in increased expression of ATF3 mRNA]
CTD
PMID:24690739 PMID:32661532
NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
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Atg101
autophagy related 101
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of ATG101 mRNA
CTD
PMID:24690739
NCBI chr 7:132,398,477...132,407,643
Ensembl chr 7:132,398,483...132,407,633
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Atp2b1
ATPase plasma membrane Ca2+ transporting 1
decreases expression
EXP
Disulfiram results in decreased expression of ATP2B1 mRNA
CTD
PMID:15003327
NCBI chr 7:33,735,595...33,845,226
Ensembl chr 7:33,735,871...33,843,295
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Atp5mk
ATP synthase membrane subunit K
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of ATP5MK mRNA
CTD
PMID:24690739
NCBI chr 1:245,973,910...245,980,702
Ensembl chr 1:245,973,914...245,980,761 Ensembl chr10:245,973,914...245,980,761
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Atp6v0d1
ATPase H+ transporting V0 subunit D1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of ATP6V0D1 mRNA
CTD
PMID:24690739
NCBI chr19:33,403,352...33,447,357
Ensembl chr19:33,403,355...33,447,450
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Atp6v1g1
ATPase H+ transporting V1 subunit G1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of ATP6V1G1 mRNA
CTD
PMID:24690739
NCBI chr 5:76,961,462...76,967,642
Ensembl chr 5:76,961,499...76,969,463
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Atxn1l
ataxin 1 like
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of ATXN1L mRNA
CTD
PMID:24690739
NCBI chr19:37,700,341...37,711,529
Ensembl chr19:37,700,106...37,711,538
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Atxn3
ataxin 3
affects localization increases response to substance
ISO
Disulfiram affects the localization of ATXN3 protein alternative form ATXN3 protein alternative form results in increased susceptibility to Disulfiram
CTD
PMID:31378764
NCBI chr 6:121,072,228...121,107,902
Ensembl chr 6:121,074,448...121,107,902
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Bad
BCL2-associated agonist of cell death
increases expression
ISO
Disulfiram results in increased expression of BAD mRNA
CTD
PMID:34182011
NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
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Bag3
BAG cochaperone 3
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of BAG3 mRNA
CTD
PMID:24690739
NCBI chr 1:183,103,038...183,126,862
Ensembl chr 1:183,102,871...183,126,858
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Bak1
BCL2-antagonist/killer 1
multiple interactions
ISO
[arsenic trioxide co-treated with Ascorbic Acid co-treated with Disulfiram] results in decreased expression of BAK1 protein
CTD
PMID:24126434
NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
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Bax
BCL2 associated X, apoptosis regulator
increases expression multiple interactions
ISO
Disulfiram results in increased expression of BAX mRNA; Disulfiram results in increased expression of BAX protein [arsenic trioxide co-treated with Ascorbic Acid co-treated with Disulfiram] results in increased expression of BAX protein; [Copper co-treated with Disulfiram] results in increased expression of BAX protein
CTD
PMID:17079463 PMID:23033007 PMID:24126434 PMID:34182011
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bbc3
Bcl-2 binding component 3
increases expression
ISO
Disulfiram results in increased expression of BBC3 mRNA
CTD
PMID:34182011
NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
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Bbs2
Bardet-Biedl syndrome 2
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of BBS2 mRNA
CTD
PMID:24690739
NCBI chr19:10,909,653...10,944,998
Ensembl chr19:10,909,619...10,944,993
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Bccip
BRCA2 and CDKN1A interacting protein
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of BCCIP mRNA
CTD
PMID:24690739
NCBI chr 1:188,512,544...188,524,957
Ensembl chr 1:188,512,367...188,524,958
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Bcl2
BCL2, apoptosis regulator
multiple interactions decreases expression
ISO
[Arsenic Trioxide co-treated with Ascorbic Acid co-treated with Disulfiram] results in decreased expression of BCL2 protein; [Copper co-treated with Disulfiram] results in decreased expression of BCL2 protein; [Disulfiram co-treated with cupric chloride] results in decreased expression of BCL2 protein Disulfiram results in decreased expression of BCL2 mRNA
CTD
PMID:21911303 PMID:23033007 PMID:24126434 PMID:34182011
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bcl2l1
Bcl2-like 1
decreases expression
ISO
Disulfiram results in decreased expression of BCL2L1 mRNA
CTD
PMID:34182011
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 Ensembl chr 1:141,253,523...141,303,479
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Bcl2l11
Bcl2-like 11
increases expression
ISO
Disulfiram results in increased expression of BCL2L11 mRNA
CTD
PMID:34182011
NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
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Bdnf
brain-derived neurotrophic factor
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of BDNF mRNA
CTD
PMID:24690739
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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Becn1
beclin 1
increases expression
ISO
Disulfiram results in increased expression of BECN1 mRNA
CTD
PMID:34182011
NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
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Bglap
bone gamma-carboxyglutamate protein
increases expression
EXP
Disulfiram results in increased expression of BGLAP mRNA
CTD
PMID:24496638
NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495
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Birc5
baculoviral IAP repeat-containing 5
increases expression
ISO
Disulfiram results in increased expression of BIRC5 protein
CTD
PMID:34182011
NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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Bmp7
bone morphogenetic protein 7
multiple interactions
ISO
Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of BMP7 mRNA]
CTD
PMID:22285649
NCBI chr 3:161,639,915...161,716,938
Ensembl chr 3:161,516,462...161,716,788
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Bnip3
BCL2 interacting protein 3
increases expression
ISO
Disulfiram results in increased expression of BNIP3 mRNA
CTD
PMID:34182011
NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
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Brf2
BRF2 general transcription factor 3B subunit
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of BRF2 mRNA
CTD
PMID:24690739
NCBI chr16:64,928,334...64,933,057
Ensembl chr16:64,928,300...64,933,059
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Btk
Bruton tyrosine kinase
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of BTK mRNA
CTD
PMID:24690739
NCBI chr X:97,722,796...97,762,315
Ensembl chr X:97,722,802...97,761,853
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C11h3orf52
similar to human chromosome 3 open reading frame 52
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of C3ORF52 mRNA
CTD
PMID:24690739
NCBI chr11:55,166,986...55,192,273
Ensembl chr11:55,166,678...55,192,292
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C1r
complement C1r
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of C1R mRNA
CTD
PMID:24690739
NCBI chr 4:157,412,718...157,423,483
Ensembl chr 4:157,412,692...157,423,484
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C1s
complement C1s
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of C1S mRNA
CTD
PMID:24690739
NCBI chr 4:157,430,249...157,442,438
Ensembl chr 4:157,430,117...157,442,303
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C3h11orf96
similar to human chromosome 11 open reading frame 96
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of C11ORF96 mRNA
CTD
PMID:24690739
NCBI chr 3:79,920,125...79,921,368
Ensembl chr 3:79,920,129...79,921,523
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C4h2orf42
similar to human chromosome 2 open reading frame 42
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of C2ORF42 mRNA
CTD
PMID:24690739
NCBI chr 4:118,887,688...118,916,808
Ensembl chr 4:118,888,112...118,916,936
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C9h2orf49
similar to human chromosome 2 open reading frame 49
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of C2ORF49 mRNA
CTD
PMID:24690739
NCBI chr 9:45,371,396...45,382,123
Ensembl chr 9:45,371,430...45,382,120
G
Cacybp
calcyclin binding protein
multiple interactions increases expression
ISO
[Disulfiram binds to Copper] which results in decreased expression of CACYBP mRNA Disulfiram results in increased expression of CACYBP mRNA; Disulfiram results in increased expression of CACYBP protein
CTD
PMID:24690739 PMID:34182011
NCBI chr13:72,437,485...72,447,810
Ensembl chr13:72,437,490...72,450,177
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Calcb
calcitonin-related polypeptide, beta
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of CALCB mRNA
CTD
PMID:24690739
NCBI chr 1:168,965,383...168,970,259
Ensembl chr 1:168,966,465...168,970,125
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Cald1
caldesmon 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of CALD1 mRNA
CTD
PMID:24690739
NCBI chr 4:63,265,781...63,446,938
Ensembl chr 4:63,265,942...63,446,932
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Calm1
calmodulin 1
decreases expression
ISO
Disulfiram results in decreased expression of CALM1 mRNA
CTD
PMID:34182011
NCBI chr 6:119,487,691...119,495,759
Ensembl chr 6:119,487,621...119,498,227
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Calm2
calmodulin 2
increases expression
ISO
Disulfiram results in increased expression of CALM2 mRNA
CTD
PMID:34182011
NCBI chr 6:7,091,624...7,104,284
Ensembl chr 6:7,091,567...7,104,287 Ensembl chr15:7,091,567...7,104,287
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Calm3
calmodulin 3
decreases expression
ISO
Disulfiram results in decreased expression of CALM3 mRNA
CTD
PMID:34182011
NCBI chr 1:77,590,668...77,597,776
Ensembl chr 1:77,589,230...77,592,207
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Car2
carbonic anhydrase 2
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of CA2 mRNA
CTD
PMID:24690739
NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
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Car7
carbonic anhydrase 7
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of CA7 mRNA
CTD
PMID:24690739
NCBI chr19:429,063...438,478
Ensembl chr19:429,075...438,467
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Casp3
caspase 3
multiple interactions increases activity
EXP ISO
[Disulfiram binds to cupric chloride] which results in increased activity of CASP3 protein; bathocuproine sulfonate inhibits the reaction [[Disulfiram binds to cupric chloride] which results in increased activity of CASP3 protein] Disulfiram results in increased activity of CASP3 protein [Disulfiram binds to Copper] which results in increased activity of CASP3 protein [Disulfiram binds to Copper] which results in increased activity of CASP3 protein; Disulfiram promotes the reaction [Carmustine results in increased cleavage of CASP3 protein]
CTD
PMID:11239917 PMID:17026967 PMID:17079463 PMID:24193513 PMID:24690739
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp7
caspase 7
increases activity
ISO
Disulfiram results in increased activity of CASP7 protein
CTD
PMID:17026967
NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
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Casp9
caspase 9
multiple interactions increases expression
ISO
[Disulfiram binds to Copper] which results in increased activity of CASP9 protein Disulfiram results in increased expression of CASP9 mRNA
CTD
PMID:24690739 PMID:34182011
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Cat
catalase
increases expression decreases expression multiple interactions
ISO
Disulfiram results in increased expression of CAT mRNA Disulfiram results in decreased expression of CAT mRNA Zinc Sulfate inhibits the reaction [Disulfiram results in decreased expression of CAT mRNA]
CTD
PMID:20566472 PMID:32712770 PMID:34182011
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Ccar1
cell division cycle and apoptosis regulator 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of CCAR1 protein
CTD
PMID:24690739
NCBI chr20:30,685,916...30,728,531
Ensembl chr20:30,685,916...30,728,526
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Ccdc59
coiled-coil domain containing 59
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of CCDC59 mRNA
CTD
PMID:24690739
NCBI chr 7:41,142,760...41,149,143
Ensembl chr 7:41,142,760...41,149,143
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Ccdc92
coiled-coil domain containing 92
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of CCDC92 mRNA
CTD
PMID:24690739
NCBI chr12:31,796,102...31,823,333
Ensembl chr12:31,796,684...31,823,337
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Cck
cholecystokinin
decreases expression multiple interactions
EXP ISO
Disulfiram results in decreased expression of CCK protein alternative form [Disulfiram binds to Copper] which results in decreased expression of CCK mRNA
CTD
PMID:8246921 PMID:24690739
NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084
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Ccl2
C-C motif chemokine ligand 2
multiple interactions decreases secretion
ISO
[Disulfiram binds to Copper] which results in increased expression of CCL2 mRNA; [Zinc Sulfate co-treated with Disulfiram] inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]; Disulfiram inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein] Disulfiram results in decreased secretion of CCL2 protein
CTD
PMID:24690739 PMID:32712770
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Ccl26
C-C motif chemokine ligand 26
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of CCL26 mRNA
CTD
PMID:24690739
NCBI chr12:21,109,384...21,114,336
Ensembl chr12:21,109,421...21,114,335
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Ccl5
C-C motif chemokine ligand 5
multiple interactions
ISO
Disulfiram inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased abundance of Nitric Oxide]; Disulfiram inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased abundance of Reactive Oxygen Species]; Disulfiram inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased secretion of TNF protein] [Disulfiram binds to Copper] which results in increased expression of CCL5 mRNA
CTD
PMID:19016906 PMID:24690739
NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
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Ccna2
cyclin A2
multiple interactions decreases expression
ISO
[Disulfiram co-treated with Copper] results in decreased expression of CCNA2 protein Disulfiram results in decreased expression of CCNA2 mRNA
CTD
PMID:15367699 PMID:34182011
NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
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Ccnd1
cyclin D1
decreases expression
ISO
Disulfiram results in decreased expression of CCND1 mRNA
CTD
PMID:34182011
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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Ccnd2
cyclin D2
multiple interactions
ISO
Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of CCND2 mRNA]
CTD
PMID:22285649
NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495
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Ccnk
cyclin K
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of CCNK mRNA
CTD
PMID:24690739
NCBI chr 6:127,090,115...127,113,195
Ensembl chr 6:127,090,569...127,113,191
G
Ccpg1
cell cycle progression 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of CCPG1 mRNA
CTD
PMID:24690739
NCBI chr 8:73,719,960...73,752,437
Ensembl chr 8:73,719,955...73,752,430
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Ccr2
C-C motif chemokine receptor 2
increases expression
ISO
Disulfiram results in increased expression of CCR2 protein
CTD
PMID:32712770
NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100
G
Ccr5
C-C motif chemokine receptor 5
multiple interactions
ISO
Disulfiram inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased abundance of Nitric Oxide]; Disulfiram inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased abundance of Reactive Oxygen Species]; Disulfiram inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased secretion of TNF protein]
CTD
PMID:19016906
NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260
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Cd163
CD163 molecule
multiple interactions decreases expression
ISO
[Zinc Sulfate co-treated with Disulfiram] results in decreased expression of CD163 mRNA Disulfiram results in decreased expression of CD163 mRNA
CTD
PMID:32712770
NCBI chr 4:157,085,080...157,118,470
Ensembl chr 4:157,085,093...157,117,878
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Cd36
CD36 molecule
multiple interactions decreases expression
ISO
[Zinc Sulfate co-treated with Disulfiram] results in decreased expression of CD36 mRNA Disulfiram results in decreased expression of CD36 mRNA
CTD
PMID:32712770
NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
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Cd46
CD46 molecule
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of CD46 mRNA
CTD
PMID:24690739
NCBI chr13:106,575,586...106,606,325
Ensembl chr13:106,574,858...106,660,445
G
Cd47
Cd47 molecule
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of CD47 mRNA
CTD
PMID:24690739
NCBI chr11:50,906,052...50,970,000
Ensembl chr11:50,906,177...50,969,425
G
Cd9
CD9 molecule
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of CD9 mRNA
CTD
PMID:24690739
NCBI chr 4:158,256,328...158,289,136
Ensembl chr 4:158,256,328...158,289,222
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Cdc42ep5
CDC42 effector protein 5
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of CDC42EP5 mRNA
CTD
PMID:24690739
NCBI chr 1:70,035,921...70,038,990
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Cdh11
cadherin 11
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of CDH11 mRNA
CTD
PMID:24690739
NCBI chr19:2,148,447...2,305,754
Ensembl chr19:2,148,458...2,304,272
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Cdh2
cadherin 2
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of CDH2 mRNA
CTD
PMID:24690739
NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
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Cdk2
cyclin dependent kinase 2
decreases expression
ISO
Disulfiram results in decreased expression of CDK2 mRNA
CTD
PMID:34182011
NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
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Cdk4
cyclin-dependent kinase 4
decreases expression
ISO
Disulfiram results in decreased expression of CDK4 mRNA
CTD
PMID:34182011
NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
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Cdk5r1
cyclin-dependent kinase 5 regulatory subunit 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of CDK5R1 mRNA
CTD
PMID:24690739
NCBI chr10:65,484,266...65,485,467
Ensembl chr10:65,483,941...65,488,456
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Cdk5rap3
CDK5 regulatory subunit associated protein 3
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of CDK5RAP3 mRNA
CTD
PMID:24690739
NCBI chr10:81,894,393...81,903,581
Ensembl chr10:81,894,393...81,903,590
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Cdk6
cyclin-dependent kinase 6
decreases expression
ISO
Disulfiram results in decreased expression of CDK6 mRNA
CTD
PMID:34182011
NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases expression
ISO
Disulfiram results in increased expression of CDKN1A mRNA
CTD
PMID:34182011
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Cdkn1b
cyclin-dependent kinase inhibitor 1B
increases expression multiple interactions
ISO
Disulfiram results in increased expression of CDKN1B mRNA; Disulfiram results in increased expression of CDKN1B protein [Disulfiram binds to Copper] which results in increased expression of CDKN1B protein
CTD
PMID:17079463 PMID:24690739 PMID:34182011
NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
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Cdkn1c
cyclin-dependent kinase inhibitor 1C
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of CDKN1C mRNA
CTD
PMID:24690739
NCBI chr 1:198,655,394...198,658,097
Ensembl chr 1:198,655,407...198,658,048
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Cdkn2aip
CDKN2A interacting protein
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of CDKN2AIP mRNA
CTD
PMID:24690739
NCBI chr16:44,536,147...44,546,216
Ensembl chr16:44,536,234...44,540,033
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Cdkn2b
cyclin-dependent kinase inhibitor 2B
increases expression
ISO
Disulfiram results in increased expression of CDKN2B mRNA
CTD
PMID:34182011
NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:104,010,680...104,019,050
G
Cemip
cell migration inducing hyaluronidase 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of CEMIP mRNA
CTD
PMID:24690739
NCBI chr 1:137,906,921...138,062,430
Ensembl chr 1:137,908,920...138,062,415
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Cenpw
centromere protein W
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of CENPW mRNA
CTD
PMID:24690739
NCBI chr 1:27,525,324...27,530,464
Ensembl chr 1:27,525,324...27,530,464
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Cfap53
cilia and flagella associated protein 53
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of CFAP53 mRNA
CTD
PMID:24690739
NCBI chr18:67,884,651...67,955,873
Ensembl chr18:67,869,855...67,952,318
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Cfb
complement factor B
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of CFB mRNA
CTD
PMID:24690739
NCBI chr20:3,970,643...3,976,510
Ensembl chr20:3,951,474...3,976,505
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Cfl1
cofilin 1
increases expression
ISO
Disulfiram results in increased expression of CFL1 protein
CTD
PMID:34182011
NCBI chr 1:202,796,012...202,801,337
Ensembl chr 1:202,786,627...202,817,587
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Chga
chromogranin A
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of CHGA mRNA
CTD
PMID:24690739
NCBI chr 6:121,696,051...121,707,399
Ensembl chr 6:121,696,051...121,707,398
G
Chmp1b
charged multivesicular body protein 1B
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of CHMP1B mRNA
CTD
PMID:24690739
NCBI chr18:60,740,349...60,742,879
G
Chordc1
cysteine and histidine rich domain containing 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of CHORDC1 mRNA
CTD
PMID:24690739
NCBI chr 8:15,374,356...15,398,436
Ensembl chr 8:15,374,471...15,399,162
G
Cilp
cartilage intermediate layer protein
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of CILP mRNA
CTD
PMID:24690739
NCBI chr 8:65,777,281...65,792,251
Ensembl chr 8:65,777,281...65,792,251
G
Cirbp
cold inducible RNA binding protein
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of CIRBP mRNA
CTD
PMID:24690739
NCBI chr 7:9,533,857...9,538,899
Ensembl chr 7:9,424,178...9,538,818
G
Ckap4
cytoskeleton-associated protein 4
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of CKAP4 mRNA
CTD
PMID:24690739
NCBI chr 7:19,230,814...19,238,914
Ensembl chr 7:19,230,203...19,238,914
G
Cldn1
claudin 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of CLDN1 mRNA
CTD
PMID:24690739
NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724
G
Clec7a
C-type lectin domain containing 7A
increases expression
ISO
Disulfiram results in increased expression of CLEC7A protein
CTD
PMID:32712770
NCBI chr 4:162,902,731...162,913,931
Ensembl chr 4:162,902,732...162,913,897
G
Clp1
cleavage factor polyribonucleotide kinase subunit 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of CLP1 mRNA
CTD
PMID:24690739
NCBI chr 3:69,806,774...69,818,633
Ensembl chr 3:69,806,778...69,810,421
G
Clta
clathrin, light chain A
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of CLTA mRNA
CTD
PMID:24690739
NCBI chr 5:58,244,253...58,263,480
Ensembl chr 5:58,245,442...58,263,472
G
Cmklr2
chemerin chemokine-like receptor 2
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of CMKLR2 mRNA
CTD
PMID:24690739
NCBI chr 9:64,583,310...64,617,883
Ensembl chr 9:64,585,594...64,586,655
G
Cntnap1
contactin associated protein 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of CNTNAP1 mRNA
CTD
PMID:24690739
NCBI chr10:86,109,850...86,125,612
Ensembl chr10:86,111,643...86,125,611
G
Col12a1
collagen type XII alpha 1 chain
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of COL12A1 mRNA
CTD
PMID:24690739
NCBI chr 8:80,547,592...80,665,665
Ensembl chr 8:80,547,593...80,665,686
G
Col1a1
collagen type I alpha 1 chain
decreases expression
ISO
Disulfiram results in decreased expression of COL1A1 protein
CTD
PMID:34182011
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
G
Col1a2
collagen type I alpha 2 chain
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of COL1A2 mRNA
CTD
PMID:24690739
NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867
G
Col3a1
collagen type III alpha 1 chain
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of COL3A1 mRNA
CTD
PMID:24690739
NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
G
Col4a1
collagen type IV alpha 1 chain
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of COL4A1 mRNA
CTD
PMID:24690739
NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412
G
Col5a1
collagen type V alpha 1 chain
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of COL5A1 mRNA
CTD
PMID:24690739
NCBI chr 3:11,208,429...11,356,715
Ensembl chr 3:11,208,512...11,354,588
G
Commd9
COMM domain containing 9
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of COMMD9 mRNA
CTD
PMID:24690739
NCBI chr 3:88,175,909...88,190,427
Ensembl chr 3:88,175,987...88,190,439
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Crabp2
cellular retinoic acid binding protein 2
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of CRABP2 mRNA
CTD
PMID:24690739
NCBI chr 2:173,417,004...173,421,352
Ensembl chr 2:173,416,857...173,421,379
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Creb1
cAMP responsive element binding protein 1
multiple interactions
ISO
[Disulfiram co-treated with Copper] results in decreased activity of CREB1 protein; Copper promotes the reaction [Disulfiram results in decreased activity of CREB1 protein]
CTD
PMID:15367699
NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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Creld2
cysteine-rich with EGF-like domains 2
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of CRELD2 mRNA
CTD
PMID:24690739
NCBI chr 7:119,909,626...119,916,556
Ensembl chr 7:119,909,633...119,916,543
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Crim1
cysteine rich transmembrane BMP regulator 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of CRIM1 mRNA
CTD
PMID:24690739
NCBI chr 6:16,695,864...16,870,264
Ensembl chr 6:16,697,829...16,870,259
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Cript
CXXC repeat containing interactor of PDZ3 domain
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of CRIPT mRNA
CTD
PMID:24690739
NCBI chr 6:7,581,428...7,589,384
Ensembl chr 6:7,580,703...7,589,399
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Crispld2
cysteine-rich secretory protein LCCL domain containing 2
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of CRISPLD2 mRNA
CTD
PMID:24690739
NCBI chr19:48,053,153...48,111,485
Ensembl chr19:48,053,287...48,110,465
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Cryab
crystallin, alpha B
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of CRYAB mRNA
CTD
PMID:24690739
NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157
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Cse1l
chromosome segregation 1 like
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of CSE1L mRNA
CTD
PMID:24690739
NCBI chr 3:155,641,104...155,678,866
Ensembl chr 3:155,641,166...155,678,865
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Csnk1e
casein kinase 1, epsilon
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of CSNK1E mRNA
CTD
PMID:24690739
NCBI chr 7:110,983,322...111,006,926
Ensembl chr 7:110,983,318...111,006,794
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Csrnp1
cysteine and serine rich nuclear protein 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of AXUD1 mRNA
CTD
PMID:24690739
NCBI chr 8:119,704,712...119,717,767
Ensembl chr 8:119,704,713...119,718,183
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Csrp2
cysteine and glycine-rich protein 2
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of CSRP2 mRNA
CTD
PMID:24690739
NCBI chr 7:46,349,109...46,367,743
Ensembl chr 7:46,348,686...46,367,745
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Cst6
cystatin E/M
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of CST6 mRNA
CTD
PMID:24690739
NCBI chr 1:202,655,322...202,657,030
Ensembl chr 1:202,655,322...202,657,030
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Cth
cystathionine gamma-lyase
increases expression
ISO
Disulfiram results in increased expression of CTH protein
CTD
PMID:34242567
NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234
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Cwc25
CWC25 spliceosome-associated protein homolog
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of CWC25 mRNA
CTD
PMID:24690739
NCBI chr10:82,735,698...82,760,373
Ensembl chr10:82,736,995...82,760,354
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Cxcr4
C-X-C motif chemokine receptor 4
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of CXCR4 mRNA
CTD
PMID:24690739
NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
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Cyp17a1
cytochrome P450, family 17, subfamily a, polypeptide 1
multiple interactions
ISO
Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of CYP17A1 mRNA]
CTD
PMID:22285649
NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
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Cyp19a1
cytochrome P450, family 19, subfamily a, polypeptide 1
multiple interactions
ISO
Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of CYP19A1 mRNA]
CTD
PMID:22285649
NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
decreases activity
ISO
Disulfiram results in decreased activity of CYP1A1 protein
CTD
PMID:33814510
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
decreases activity
ISO
Disulfiram results in decreased activity of CYP1B1 protein
CTD
PMID:33814510
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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Cyp2b1
cytochrome P450, family 2, subfamily b, polypeptide 1
multiple interactions increases expression
EXP
GH1 protein inhibits the reaction [Disulfiram results in increased expression of CYP2B1 mRNA]
CTD
PMID:8390837
NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
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Cyp2b2
cytochrome P450, family 2, subfamily b, polypeptide 2
increases expression multiple interactions
EXP
Disulfiram results in increased expression of CYP2B2 mRNA GH1 protein inhibits the reaction [Disulfiram results in increased expression of CYP2B2 mRNA]
CTD
PMID:8390837
NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566
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Cyp2c11
cytochrome P450, subfamily 2, polypeptide 11
decreases activity decreases expression
EXP
Disulfiram results in decreased activity of CYP2C11 protein Disulfiram results in decreased expression of CYP2C11 protein
CTD
PMID:9393675
NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
multiple interactions decreases activity decreases expression
ISO EXP
[Disulfiram results in decreased activity of CYP2E1 protein] which affects the activity of Styrene; Disulfiram inhibits the reaction [[CYP2E1 protein results in increased metabolism of Chlorzoxazone] which results in increased chemical synthesis of 6-hydroxychlorzoxazone]; Disulfiram inhibits the reaction [CYP2E1 protein results in increased chemical synthesis of 6-hydroxychlorzoxazone]; Disulfiram inhibits the reaction [CYP2E1 protein results in increased metabolism of Chlorzoxazone]; Disulfiram inhibits the reaction [CYP2E1 protein results in increased oxidation of Halothane] Disulfiram binds to and results in decreased activity of CYP2E1 protein Disulfiram results in decreased expression of CYP2E1 mRNA; Disulfiram results in decreased expression of CYP2E1 protein
CTD
PMID:1664256 PMID:8637342 PMID:9393675 PMID:10805064 PMID:18754103 PMID:20470765 PMID:21915887 PMID:23669205 More...
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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Cyp2r1
cytochrome P450, family 2, subfamily r, polypeptide 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of CYP2R1 mRNA
CTD
PMID:24690739
NCBI chr 1:168,749,302...168,798,079
Ensembl chr 1:168,751,038...168,797,759
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
decreases expression decreases activity increases response to substance
EXP ISO
Disulfiram results in decreased expression of CYP3A2 mRNA Disulfiram results in decreased activity of CYP3A2 protein CYP3A4 protein results in increased susceptibility to Disulfiram
CTD
PMID:9393675 PMID:21540358
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Dag1
dystroglycan 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of DAG1 mRNA
CTD
PMID:24690739
NCBI chr 8:108,890,926...108,955,611
Ensembl chr 8:108,890,929...108,952,325
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Dbh
dopamine beta-hydroxylase
decreases activity affects response to substance
ISO
Disulfiram results in decreased activity of DBH protein DBH gene polymorphism affects the susceptibility to Disulfiram DBH gene SNP affects the susceptibility to Disulfiram
CTD
PMID:90468 PMID:16163519 PMID:19462300
NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248
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Dcaf13
DDB1 and CUL4 associated factor 13
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of DCAF13 mRNA
CTD
PMID:24690739
NCBI chr 7:70,160,983...70,196,142
Ensembl chr 7:70,160,941...70,196,142
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Dcxr
dicarbonyl and L-xylulose reductase
multiple interactions
ISO
[Disulfiram co-treated with NADP] binds to DCXR protein
CTD
PMID:25526675
NCBI chr10:106,006,404...106,008,293
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Ddit3
DNA-damage inducible transcript 3
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of DDIT3 mRNA
CTD
PMID:24690739
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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Ddx39a
DExD-box helicase 39A
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of DDX39A mRNA
CTD
PMID:24690739
NCBI chr19:24,418,743...24,427,422
Ensembl chr19:24,418,114...24,426,954
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Ddx60
DEXD/H-box helicase 60
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of DDX60 mRNA
CTD
PMID:24690739
NCBI chr16:28,077,000...28,197,903
Ensembl chr16:28,076,999...28,179,526
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Dedd2
death effector domain containing 2
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of DEDD2 mRNA
CTD
PMID:24690739
NCBI chr 1:80,789,084...80,807,789
Ensembl chr 1:80,792,000...80,807,714
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Dhdh
dihydrodiol dehydrogenase
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of DHDH mRNA
CTD
PMID:24690739
NCBI chr 1:95,954,361...95,965,262
Ensembl chr 1:95,953,092...95,965,197
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Dhrs2
dehydrogenase/reductase 2
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of DHRS2 mRNA
CTD
PMID:24690739
NCBI chr15:28,688,881...28,703,646
Ensembl chr15:28,688,940...28,703,644
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Dhrs3
dehydrogenase/reductase 3
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of DHRS3 mRNA
CTD
PMID:24690739
NCBI chr 5:156,747,939...156,782,420
Ensembl chr 5:156,747,962...156,782,417
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Dkk3
dickkopf WNT signaling pathway inhibitor 3
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of DKK3 mRNA
CTD
PMID:24690739
NCBI chr 1:166,237,969...166,281,271
Ensembl chr 1:166,238,238...166,280,590
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Dll1
delta like canonical Notch ligand 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of DLL1 mRNA
CTD
PMID:24690739
NCBI chr 1:56,312,062...56,320,177
Ensembl chr 1:56,312,066...56,320,179
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Dnaja1
DnaJ heat shock protein family (Hsp40) member A1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of DNAJA1 mRNA
CTD
PMID:24690739
NCBI chr 5:55,842,414...55,853,326
Ensembl chr 5:55,842,426...55,853,967
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Dnaja4
DnaJ heat shock protein family (Hsp40) member A4
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of DNAJA4 mRNA
CTD
PMID:24690739
NCBI chr 8:55,085,246...55,102,715
Ensembl chr 8:55,085,464...55,101,207
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Dnajb1
DnaJ heat shock protein family (Hsp40) member B1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of DNAJB1 mRNA
CTD
PMID:24690739
NCBI chr19:24,522,731...24,526,419
Ensembl chr19:24,522,717...24,526,458
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Dnajb6
DnaJ heat shock protein family (Hsp40) member B6
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of DNAJB6 mRNA
CTD
PMID:24690739
NCBI chr 4:5,452,683...5,556,679
Ensembl chr 4:5,452,683...5,556,659
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Dnajc3
DnaJ heat shock protein family (Hsp40) member C3
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of DNAJC3 mRNA
CTD
PMID:24690739
NCBI chr15:96,025,605...96,068,585
Ensembl chr15:96,025,624...96,065,181
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Dph3
diphthamide biosynthesis 3
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of DPH3 mRNA
CTD
PMID:24690739
NCBI chr16:7,288,295...7,293,734
Ensembl chr16:7,282,705...7,291,265
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Dram1
DNA-damage regulated autophagy modulator 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of DRAM1 mRNA
CTD
PMID:24690739
NCBI chr 7:22,742,794...22,776,888
Ensembl chr 7:22,742,849...22,776,765
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Dse
dermatan sulfate epimerase
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of DSE mRNA
CTD
PMID:24690739
NCBI chr20:26,118,194...26,196,889
Ensembl chr20:26,118,196...26,196,992
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Dusp2
dual specificity phosphatase 2
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of DUSP2 mRNA
CTD
PMID:24690739
NCBI chr 3:114,556,325...114,558,510
Ensembl chr 3:114,556,325...114,558,499
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Dusp5
dual specificity phosphatase 5
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of DUSP5 mRNA
CTD
PMID:24690739
NCBI chr 1:252,538,408...252,555,320
Ensembl chr 1:252,538,449...252,551,818
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Dynll2
dynein light chain LC8-type 2
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of DYNLL2 mRNA
CTD
PMID:24690739
NCBI chr10:72,767,035...72,785,824
Ensembl chr10:72,767,035...72,785,805
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Eaf1
ELL associated factor 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of EAF1 mRNA
CTD
PMID:24690739
NCBI chr16:6,698,322...6,713,071
Ensembl chr16:6,698,322...6,713,071
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Edil3
EGF like repeats and discoidin domains 3
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of EDIL3 mRNA
CTD
PMID:24690739
NCBI chr 2:19,890,396...20,405,028
Ensembl chr 2:19,890,373...20,405,008
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Eed
embryonic ectoderm development
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of EED mRNA
CTD
PMID:24690739
NCBI chr 1:143,867,875...143,895,008
Ensembl chr 1:143,867,875...143,894,974
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Efemp1
EGF containing fibulin extracellular matrix protein 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of EFEMP1 mRNA
CTD
PMID:24690739
NCBI chr14:102,610,813...102,690,027
Ensembl chr14:102,610,908...102,690,018
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Egr1
early growth response 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of EGR1 mRNA
CTD
PMID:24690739
NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
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Eif4a3
eukaryotic translation initiation factor 4A3
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of EIF4A3 mRNA
CTD
PMID:24690739
NCBI chr10:104,549,038...104,559,032
Ensembl chr10:104,549,038...104,559,057
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Ell2
elongation factor for RNA polymerase II 2
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of ELL2 mRNA
CTD
PMID:24690739
NCBI chr 2:5,189,375...5,258,781
Ensembl chr 2:5,189,971...5,258,781
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Elof1
elongation factor 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of ELOF1 mRNA
CTD
PMID:24690739
NCBI chr 8:20,645,336...20,650,888
Ensembl chr 8:20,645,336...20,650,579
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Esr1
estrogen receptor 1
multiple interactions
ISO
Disulfiram binds to and results in decreased activity of ESR1 protein
CTD
PMID:33049310
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Ets1
ETS proto-oncogene 1, transcription factor
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of ETS1 mRNA
CTD
PMID:24690739
NCBI chr 8:31,045,909...31,168,010
Ensembl chr 8:31,045,945...31,168,010
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F12
coagulation factor XII
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of F12 mRNA
CTD
PMID:24690739
NCBI chr17:9,207,683...9,215,530
Ensembl chr17:9,207,683...9,215,530
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Fam210a
family with sequence similarity 210, member A
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of FAM210A mRNA
CTD
PMID:24690739
NCBI chr18:61,846,447...61,886,123
Ensembl chr18:61,852,907...61,886,171
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Fam234a
family with sequence similarity 234, member A
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of FAM234A mRNA
CTD
PMID:24690739
NCBI chr10:15,232,267...15,263,529
Ensembl chr10:15,232,278...15,263,488
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Fam32a
family with sequence similarity 32, member A
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of FAM32A mRNA
CTD
PMID:24690739
NCBI chr16:17,603,054...17,607,376
Ensembl chr16:17,603,946...17,607,398
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Faslg
Fas ligand
increases expression
ISO
Disulfiram results in increased expression of FASLG mRNA
CTD
PMID:34182011
NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
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Fech
ferrochelatase
increases expression
ISO
Disulfiram results in increased expression of FECH mRNA
CTD
PMID:20566472
NCBI chr18:57,945,123...57,978,327
Ensembl chr18:57,945,122...57,979,348
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Fkbp1a
FKBP prolyl isomerase 1A
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of FKBP1A mRNA
CTD
PMID:24690739
NCBI chr 3:140,040,359...140,060,107
Ensembl chr 3:140,040,278...140,060,743
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Flcn
folliculin
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of FLCN mRNA
CTD
PMID:24690739
NCBI chr10:44,588,621...44,607,808
Ensembl chr10:44,588,624...44,607,769
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Fndc11
fibronectin type III domain containing 11
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of FNDC11 mRNA
CTD
PMID:24690739
NCBI chr 3:168,330,607...168,333,111
Ensembl chr 3:168,330,602...168,334,617
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of FOS mRNA
CTD
PMID:24690739
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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Fosb
FosB proto-oncogene, AP-1 transcription factor subunit
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of FOSB mRNA
CTD
PMID:24690739
NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465
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Foxa3
forkhead box A3
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of FOXA3 mRNA
CTD
PMID:24690739
NCBI chr 1:78,662,067...78,672,321
Ensembl chr 1:78,662,431...78,672,155
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Foxj1
forkhead box J1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of FOXJ1 mRNA
CTD
PMID:24690739
NCBI chr10:101,566,299...101,570,370
Ensembl chr10:101,566,304...101,570,237
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Foxo1
forkhead box O1
increases expression
ISO
Disulfiram results in increased expression of FOXO1 mRNA
CTD
PMID:34182011
NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
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Foxo3
forkhead box O3
increases expression
ISO
Disulfiram results in increased expression of FOXO3 mRNA
CTD
PMID:34182011
NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
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Foxo4
forkhead box O4
increases expression
ISO
Disulfiram results in increased expression of FOXO4 mRNA
CTD
PMID:34182011
NCBI chr X:66,385,241...66,392,115
Ensembl chr X:66,385,558...66,392,115
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Frg1
FSHD region gene 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of FRG1 mRNA
CTD
PMID:24690739
NCBI chr16:50,925,783...50,946,661
Ensembl chr16:50,925,803...50,946,661
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Fshb
follicle stimulating hormone subunit beta
multiple interactions
ISO
Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of BMP7 mRNA]; Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of CCND2 mRNA]; Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of CYP17A1 mRNA]; Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of CYP19A1 mRNA]; Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of FSHR mRNA]; Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of LHCGR mRNA]; Tretinoin inhibits the reaction [Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of LHCGR mRNA]]
CTD
PMID:22285649
NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
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Fshr
follicle stimulating hormone receptor
multiple interactions
ISO
Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of FSHR mRNA]
CTD
PMID:22285649
NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785
G
Fstl1
follistatin-like 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of FSTL1 mRNA
CTD
PMID:24690739
NCBI chr11:62,895,391...62,948,581
Ensembl chr11:62,779,783...62,948,677
G
Ftcd
formimidoyltransferase cyclodeaminase
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of FTCD mRNA
CTD
PMID:24690739
NCBI chr20:12,055,203...12,068,717
Ensembl chr20:12,055,208...12,068,735
G
Ftl1
ferritin light chain 1
increases expression
ISO
Disulfiram results in increased expression of FTL mRNA
CTD
PMID:20566472
NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725 Ensembl chr10:95,936,387...95,939,725 Ensembl chr 2:95,936,387...95,939,725
G
G6pd
glucose-6-phosphate dehydrogenase
increases expression
ISO
Disulfiram results in increased expression of G6PD mRNA
CTD
PMID:20566472
NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
G
Gadd45a
growth arrest and DNA-damage-inducible, alpha
increases expression
ISO
Disulfiram results in increased expression of GADD45A mRNA
CTD
PMID:34182011
NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
G
Gadd45b
growth arrest and DNA-damage-inducible, beta
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of GADD45B mRNA
CTD
PMID:24690739
NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046
G
Galnt10
polypeptide N-acetylgalactosaminyltransferase 10
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of GALNT10 mRNA
CTD
PMID:24690739
NCBI chr10:41,821,216...41,967,618
Ensembl chr10:41,820,158...41,967,013
G
Gas6
growth arrest specific 6
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of GAS6 mRNA
CTD
PMID:24690739
NCBI chr16:76,045,430...76,075,904
Ensembl chr16:76,045,426...76,075,904
G
Gata2
GATA binding protein 2
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of GATA2 mRNA
CTD
PMID:24690739
NCBI chr 4:120,654,205...120,667,763
Ensembl chr 4:120,658,986...120,667,761
G
Gbp4
guanylate binding protein 4
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of GBP4 mRNA
CTD
PMID:24690739
NCBI chr 2:231,304,910...231,318,883
Ensembl chr 2:231,305,244...231,318,879
G
Gcc1
GRIP and coiled-coil domain containing 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of GCC1 mRNA
CTD
PMID:24690739
NCBI chr 4:57,030,817...57,042,682
Ensembl chr 4:57,032,314...57,042,663
G
Gcgr
glucagon receptor
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of GCGR mRNA
CTD
PMID:24690739
NCBI chr10:105,808,474...105,816,641
Ensembl chr10:105,808,473...105,816,640
G
Gclc
glutamate-cysteine ligase, catalytic subunit
increases expression
ISO
Disulfiram results in increased expression of GCLC mRNA
CTD
PMID:20566472
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
G
Gclm
glutamate cysteine ligase, modifier subunit
increases expression
ISO
Disulfiram results in increased expression of GCLM mRNA
CTD
PMID:20566472
NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
G
Gem
GTP binding protein overexpressed in skeletal muscle
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of GEM mRNA
CTD
PMID:24690739
NCBI chr 5:25,214,309...25,225,222
Ensembl chr 5:25,214,309...25,225,222
G
Gemin6
gem (nuclear organelle) associated protein 6
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of GEMIN6 mRNA
CTD
PMID:24690739
NCBI chr 6:14,786,090...14,790,617
Ensembl chr 6:14,786,070...14,790,612
G
Gh1
growth hormone 1
multiple interactions
EXP
GH1 protein inhibits the reaction [Disulfiram results in increased expression of CYP2B1 mRNA]; GH1 protein inhibits the reaction [Disulfiram results in increased expression of CYP2B2 mRNA]
CTD
PMID:8390837
NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078
G
Glg1
golgi glycoprotein 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of GLG1 mRNA
CTD
PMID:24690739
NCBI chr19:39,124,892...39,224,178
Ensembl chr19:39,124,641...39,224,178
G
Glrx2
glutaredoxin 2
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of GLRX2 mRNA
CTD
PMID:24690739
NCBI chr13:55,481,875...55,504,737
Ensembl chr13:55,482,694...55,492,831
G
Gosr2
golgi SNAP receptor complex member 2
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of GOSR2 mRNA
CTD
PMID:24690739
NCBI chr10:88,585,291...88,605,642
Ensembl chr10:88,586,299...88,605,625
G
Gpsm1
G-protein signaling modulator 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of GPSM1 mRNA
CTD
PMID:24690739
NCBI chr 3:9,140,816...9,167,828
Ensembl chr 3:9,128,636...9,167,827
G
Gpt2
glutamic--pyruvic transaminase 2
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of GPT2 mRNA
CTD
PMID:24690739
NCBI chr19:21,526,800...21,561,314
Ensembl chr19:21,517,621...21,560,610
G
Gpx3
glutathione peroxidase 3
increases expression
ISO
Disulfiram results in increased expression of GPX3 mRNA
CTD
PMID:20566472
NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035
G
Gramd1a
GRAM domain containing 1A
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of GRAMD1A mRNA
CTD
PMID:24690739
NCBI chr 1:86,367,001...86,393,348
Ensembl chr 1:86,367,001...86,393,336
G
Gramd2b
GRAM domain containing 2B
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of GRAMD2B mRNA
CTD
PMID:24690739
NCBI chr18:49,884,014...49,981,955
Ensembl chr18:49,884,014...49,981,953
G
Grwd1
glutamate-rich WD repeat containing 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of GRWD1 mRNA
CTD
PMID:24690739
NCBI chr 1:96,301,260...96,306,962
Ensembl chr 1:96,301,261...96,307,201
G
Gsdmd
gasdermin D
decreases cleavage multiple interactions
ISO
Disulfiram results in decreased cleavage of GSDMD protein Disulfiram binds to and results in decreased activity of GSDMD protein; Disulfiram inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of GSDMD protein]
CTD
PMID:32367036 PMID:33851234
NCBI chr 7:107,542,489...107,547,051
Ensembl chr 7:107,542,083...107,547,055
G
Gsdme
gasdermin E
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of GSDME mRNA
CTD
PMID:24690739
NCBI chr 4:79,258,799...79,321,129
Ensembl chr 4:79,257,804...79,320,806
G
Gsr
glutathione-disulfide reductase
increases expression
ISO
Disulfiram results in increased expression of GSR mRNA
CTD
PMID:20566472
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
G
Gtf2b
general transcription factor IIB
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of GTF2B mRNA
CTD
PMID:24690739
NCBI chr 2:231,767,317...231,785,626
Ensembl chr 2:231,767,238...231,785,651
G
H2ac20
H2A clustered histone 20
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of H2AC20 mRNA
CTD
PMID:24690739
NCBI chr 2:183,779,879...183,780,357
G
H2ax
H2A.X variant histone
multiple interactions increases expression
ISO
Disulfiram inhibits the reaction [captax results in increased expression of H2AX protein]; Disulfiram inhibits the reaction [propylene dichloride results in increased phosphorylation of H2AX protein]; Disulfiram inhibits the reaction [Trichloroethylene results in increased phosphorylation of H2AX protein] Disulfiram results in increased expression of H2AX protein
CTD
PMID:28300663 PMID:29722447 PMID:34830855 PMID:35279910
NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 Ensembl chr 4:44,671,786...44,673,239
G
H2bc12
H2B clustered histone 12
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of H2BC12 mRNA
CTD
PMID:24690739
NCBI chr17:42,485,699...42,486,162
G
H2bc8
H2B clustered histone 8
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of H2BC8 mRNA
CTD
PMID:24690739
NCBI chr17:42,708,658...42,709,408
G
H3f4
H3.4 histone, cluster member
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of H3-4 mRNA
CTD
PMID:24690739
NCBI chr10:43,740,702...43,741,262
G
H6pd
hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of H6PD mRNA
CTD
PMID:24690739
NCBI chr 5:160,434,499...160,470,203
Ensembl chr 5:160,438,697...160,470,171
G
Hba-a2
hemoglobin alpha, adult chain 2
multiple interactions increases expression
ISO
[Disulfiram binds to Copper] which results in decreased expression of HBA1 mRNA Disulfiram results in increased expression of HBA1 protein
CTD
PMID:24690739 PMID:34182011
NCBI chr10:15,323,830...15,324,677
Ensembl chr10:15,307,815...15,338,392 Ensembl chr10:15,307,815...15,338,392
G
Hbegf
heparin-binding EGF-like growth factor
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of HBEGF mRNA
CTD
PMID:24690739
NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441
G
Hes1
hes family bHLH transcription factor 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of HES1 mRNA
CTD
PMID:24690739
NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192
G
Hes6
hes family bHLH transcription factor 6
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of HES6 mRNA
CTD
PMID:24690739
NCBI chr 9:92,001,849...92,003,562
Ensembl chr 9:92,001,841...92,003,559
G
Hmox1
heme oxygenase 1
increases expression multiple interactions
ISO
Disulfiram results in increased expression of HMOX1 mRNA [Disulfiram binds to Copper] which results in decreased expression of HMOX1 mRNA; [Disulfiram co-treated with Zinc Sulfate] results in increased expression of HMOX1 mRNA; MTF1 protein affects the reaction [Disulfiram results in increased expression of HMOX1 mRNA]
CTD
PMID:20566472 PMID:24690739 PMID:32661532 PMID:32712770
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
G
Hnrnpa2b1
heterogeneous nuclear ribonucleoprotein A2/B1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of HNRNPA2B1 mRNA
CTD
PMID:24690739
NCBI chr 4:80,534,659...80,545,297
Ensembl chr 4:80,534,651...80,545,249
G
Hoxa1
homeobox A1
multiple interactions
ISO
Disulfiram inhibits the reaction [Vitamin A results in increased expression of HOXA1 mRNA]
CTD
PMID:23696197
NCBI chr 4:81,255,814...81,258,587
Ensembl chr 4:81,255,883...81,258,504
G
Hoxd1
homeo box D1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of HOXD1 mRNA
CTD
PMID:24690739
NCBI chr 3:59,665,629...59,667,769
Ensembl chr 3:59,665,629...59,667,769
G
Hrk
harakiri, BCL2 interacting protein
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of HRK mRNA
CTD
PMID:24690739
NCBI chr12:38,387,484...38,409,652
G
Hs3st2
heparan sulfate-glucosamine 3-sulfotransferase 2
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of HS3ST2 mRNA
CTD
PMID:24690739
NCBI chr 1:175,956,161...176,077,400
Ensembl chr 1:175,956,157...176,077,399
G
Hsd11b1
hydroxysteroid 11-beta dehydrogenase 1
multiple interactions
ISO
[Disulfiram co-treated with NAD] binds to HSD11B1 protein
CTD
PMID:25526675
NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687
G
Hsd11b2
hydroxysteroid 11-beta dehydrogenase 2
decreases activity
ISO
Disulfiram results in decreased activity of HSD11B2 protein
CTD
PMID:22796344
NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899
G
Hsp90aa1
heat shock protein 90 alpha family class A member 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of HSP90AA1 mRNA
CTD
PMID:24690739
NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
G
Hsp90ab1
heat shock protein 90 alpha family class B member 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of HSP90AB1 mRNA
CTD
PMID:24690739
NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488
G
Hspa1a
heat shock protein family A (Hsp70) member 1A
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of HSPA1A mRNA
CTD
PMID:24690739
NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227
G
Hspa1b
heat shock protein family A (Hsp70) member 1B
increases expression multiple interactions
ISO
Disulfiram results in increased expression of HSPA1B mRNA [Disulfiram binds to Copper] which results in decreased expression of HSPA1B mRNA
CTD
PMID:20566472 PMID:24690739
NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240 Ensembl chr20:3,856,006...3,873,240
G
Hspa1l
heat shock protein family A (Hsp70) member 1 like
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of HSPA1L mRNA
CTD
PMID:24690739
NCBI chr20:3,848,843...3,855,571
Ensembl chr20:3,848,843...3,855,571
G
Hspa4
heat shock protein family A (Hsp70) member 4
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of HSPA4 mRNA
CTD
PMID:24690739
NCBI chr10:37,408,025...37,449,080
Ensembl chr10:37,408,025...37,449,001
G
Hspa6l-ps1
heat shock protein family A (Hsp70) member 6 like, pseudogene 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of HSPA6 mRNA
CTD
PMID:24690739
NCBI chr13:83,273,176...83,274,317
G
Hspa8
heat shock protein family A (Hsp70) member 8
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of HSPA8 mRNA
CTD
PMID:24690739
NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
G
Hspb1
heat shock protein family B (small) member 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of HSPB1 mRNA
CTD
PMID:24690739
NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
G
Hspb8
heat shock protein family B (small) member 8
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of HSPB8 mRNA
CTD
PMID:24690739
NCBI chr12:40,176,405...40,205,002
Ensembl chr12:40,176,532...40,191,185
G
Hsph1
heat shock protein family H (Hsp110) member 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of HSPH1 mRNA
CTD
PMID:24690739
NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224
G
Htr2b
5-hydroxytryptamine receptor 2B
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of HTR2B mRNA
CTD
PMID:24690739
NCBI chr 9:86,735,793...86,756,638
Ensembl chr 9:86,742,102...86,755,108
G
Id2
inhibitor of DNA binding 2
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of ID2 mRNA
CTD
PMID:24690739
NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400
G
Ier5
immediate early response 5
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of IER5 mRNA
CTD
PMID:24690739
NCBI chr13:67,270,134...67,272,226
Ensembl chr13:67,270,135...67,272,227
G
Ifit2
interferon-induced protein with tetratricopeptide repeats 2
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of IFIT2 mRNA
CTD
PMID:24690739
NCBI chr 1:232,102,570...232,108,638
Ensembl chr 1:232,102,570...232,108,635
G
Ifit3
interferon-induced protein with tetratricopeptide repeats 3
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of IFIT3 mRNA
CTD
PMID:24690739
NCBI chr 1:232,114,166...232,119,311
Ensembl chr 1:232,114,166...232,119,307
G
Ifngr2
interferon gamma receptor 2
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of IFNGR2 mRNA
CTD
PMID:24690739
NCBI chr11:30,779,733...30,798,005
Ensembl chr11:30,779,733...30,798,005
G
Igf2r
insulin-like growth factor 2 receptor
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of IGF2R mRNA
CTD
PMID:24690739
NCBI chr 1:47,979,109...48,067,501
Ensembl chr 1:47,979,109...48,067,501
G
Igfbp7
insulin-like growth factor binding protein 7
multiple interactions increases expression
ISO
[Disulfiram binds to Copper] which results in increased expression of IGFBP7 mRNA; [Disulfiram binds to Copper] which results in increased expression of IGFBP7 protein [Disulfiram cotreated with copper(+2)] increases expression of IGFBP7 mRNA in malignant pleural mesothelioma cells
CTD RGD
PMID:24690739 PMID:24690739
RGD:401960877
NCBI chr14:30,737,414...30,797,317
Ensembl chr14:30,737,164...30,797,314
G
Il18
interleukin 18
multiple interactions
ISO
[Disulfiram co-treated with Adenosine Triphosphate] inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL18 protein]; Disulfiram inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL18 protein]
CTD
PMID:33579316 PMID:33851234
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
G
Il1a
interleukin 1 alpha
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of IL1A mRNA
CTD
PMID:24690739
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
G
Il1b
interleukin 1 beta
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of IL1B mRNA; [Disulfiram co-treated with Adenosine Triphosphate] inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; [Disulfiram co-treated with Zinc Sulfate] inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; Disulfiram inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; Disulfiram inhibits the reaction [Nigericin results in increased secretion of IL1B protein] Disulfiram inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]
CTD
PMID:24690739 PMID:32367036 PMID:32712770 PMID:33579316 PMID:33851234
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Il6
interleukin 6
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of IL6 mRNA; [Disulfiram co-treated with Zinc Sulfate] inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Disulfiram inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL6 protein]
CTD
PMID:24690739 PMID:32712770 PMID:33851234
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
G
Insig1
insulin induced gene 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of INSIG1 mRNA
CTD
PMID:24690739
NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952
G
Irf8
interferon regulatory factor 8
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of IRF8 mRNA
CTD
PMID:24690739
NCBI chr19:48,790,581...48,812,363
Ensembl chr19:48,790,588...48,811,829
G
Isy1
ISY1 splicing factor homolog
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of ISY1 mRNA
CTD
PMID:24690739
NCBI chr 4:120,276,535...120,297,227
Ensembl chr 4:120,276,292...120,297,188
G
Itga11
integrin subunit alpha 11
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of ITGA11 mRNA
CTD
PMID:24690739
NCBI chr 8:63,145,998...63,254,714
Ensembl chr 8:63,146,001...63,254,407
G
Itga3
integrin subunit alpha 3
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of ITGA3 mRNA
CTD
PMID:24690739
NCBI chr10:79,990,160...80,022,206
Ensembl chr10:79,990,161...80,022,118
G
Itgam
integrin subunit alpha M
increases expression
ISO
Disulfiram results in increased expression of ITGAM protein
CTD
PMID:32712770
NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503
G
Itgav
integrin subunit alpha V
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of ITGAV mRNA
CTD
PMID:24690739
NCBI chr 3:68,838,514...68,926,653
Ensembl chr 3:68,838,189...68,926,639
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Itgb1
integrin subunit beta 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of ITGB1 mRNA
CTD
PMID:24690739
NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
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Itgb5
integrin subunit beta 5
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of ITGB5 mRNA
CTD
PMID:24690739
NCBI chr11:66,828,428...66,944,231
Ensembl chr11:66,829,285...66,944,472
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Jag2
jagged canonical Notch ligand 2
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of JAG2 mRNA
CTD
PMID:24690739
NCBI chr 6:131,983,059...132,005,665
Ensembl chr 6:131,983,056...132,005,818
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Jun
Jun proto-oncogene, AP-1 transcription factor subunit
multiple interactions
ISO
[Copper co-treated with Disulfiram co-treated with Gemcitabine] results in increased expression of and results in increased phosphorylation of JUN protein; [Copper co-treated with Disulfiram] results in increased expression of and results in increased phosphorylation of JUN protein; [Disulfiram co-treated with cupric chloride co-treated with Doxorubicin] results in increased expression of and results in increased phosphorylation of JUN protein; Acetylcysteine inhibits the reaction [[Copper co-treated with Disulfiram] results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [[Disulfiram co-treated with Copper co-treated with Doxorubicin] results in increased phosphorylation of and results in increased expression of JUN protein]
CTD
PMID:21911303 PMID:23033007
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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Kcng1
potassium voltage-gated channel modifier subfamily G member 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of KCNG1 mRNA
CTD
PMID:24690739
NCBI chr 3:156,960,717...156,992,877
Ensembl chr 3:156,973,156...156,992,635
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Khdrbs3
KH RNA binding domain containing, signal transduction associated 3
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of KHDRBS3 mRNA
CTD
PMID:24690739
NCBI chr 7:100,837,707...100,995,644
Ensembl chr 7:100,837,934...100,988,460
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Klf10
KLF transcription factor 10
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of KLF10 mRNA
CTD
PMID:24690739
NCBI chr 7:69,467,658...69,473,726
Ensembl chr 7:69,465,619...69,473,994
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Klhl22
kelch-like family member 22
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of KLHL22 mRNA
CTD
PMID:24690739
NCBI chr11:83,190,891...83,231,746
Ensembl chr11:83,190,891...83,231,770
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Klhl5
kelch-like family member 5
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of KLHL5 mRNA
CTD
PMID:24690739
NCBI chr14:43,144,254...43,206,192
Ensembl chr14:43,144,257...43,184,238
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Krt1
keratin 1
increases expression
ISO
Disulfiram results in increased expression of KRT1 mRNA; Disulfiram results in increased expression of KRT1 protein
CTD
PMID:34182011
NCBI chr 7:132,976,618...132,981,844
Ensembl chr 7:132,976,620...132,981,844
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Krt75
keratin 75
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of KRT75 mRNA
CTD
PMID:24690739
NCBI chr 7:132,687,101...132,697,360
Ensembl chr 7:132,688,237...132,697,345
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Lamc1
laminin subunit gamma 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of LAMC1 mRNA
CTD
PMID:24690739
NCBI chr13:65,374,372...65,501,492
Ensembl chr13:65,374,372...65,501,492
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Lamtor3
late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of LAMTOR3 mRNA
CTD
PMID:24690739
NCBI chr 2:226,411,389...226,423,612
Ensembl chr 2:226,411,400...226,423,607
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Lemd2
LEM domain nuclear envelope protein 2
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of LEMD2 mRNA
CTD
PMID:24690739
NCBI chr20:5,282,397...5,296,621
Ensembl chr20:5,282,397...5,296,626
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Lhb
luteinizing hormone subunit beta
multiple interactions
ISO
Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of BMP7 mRNA]; Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of CCND2 mRNA]; Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of CYP17A1 mRNA]; Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of CYP19A1 mRNA]; Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of FSHR mRNA]; Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of LHCGR mRNA]; Tretinoin inhibits the reaction [Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of LHCGR mRNA]]
CTD
PMID:22285649
NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972 Ensembl chr 1:95,900,984...95,901,972
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Lhcgr
luteinizing hormone/choriogonadotropin receptor
multiple interactions
ISO
Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of LHCGR mRNA]; Tretinoin inhibits the reaction [Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of LHCGR mRNA]]
CTD
PMID:22285649
NCBI chr 6:5,661,871...5,728,109
Ensembl chr 6:5,661,871...5,724,521
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Limch1
LIM and calponin homology domains 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of LIMCH1 mRNA
CTD
PMID:24690739
NCBI chr14:41,112,579...41,425,001
Ensembl chr14:41,114,803...41,425,191
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Lipt1
lipoyltransferase 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of LIPT1 mRNA
CTD
PMID:24690739
NCBI chr 9:40,107,938...40,118,268
Ensembl chr 9:40,098,615...40,113,565
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Lmcd1
LIM and cysteine-rich domains 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of LMCD1 mRNA
CTD
PMID:24690739
NCBI chr 4:145,393,153...145,452,049
Ensembl chr 4:145,393,145...145,452,046
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Lmtk2
lemur tyrosine kinase 2
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of LMTK2 mRNA
CTD
PMID:24690739
NCBI chr12:10,426,772...10,508,750
Ensembl chr12:10,426,777...10,508,750
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Loricrin
loricrin cornified envelope precursor protein
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of LORICRIN mRNA
CTD
PMID:24690739
NCBI chr 2:177,558,062...177,560,960
Ensembl chr 2:177,558,252...177,559,807
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Lratd2
LRAT domain containing 2
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of LRATD2 mRNA
CTD
PMID:24690739
NCBI chr 7:92,376,713...92,387,045
Ensembl chr 7:92,362,194...92,388,189
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Lrp8
LDL receptor related protein 8
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of LRP8 mRNA
CTD
PMID:24690739
NCBI chr 5:122,563,468...122,635,434
Ensembl chr 5:122,563,453...122,631,352
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Lsmem1
leucine-rich single-pass membrane protein 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of LSMEM1 mRNA
CTD
PMID:24690739
NCBI chr 6:57,251,720...57,261,590
Ensembl chr 6:57,252,056...57,261,653
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Ltb4r
leukotriene B4 receptor
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of LTB4R mRNA
CTD
PMID:24690739
NCBI chr15:29,263,199...29,265,716
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Luc7l3
LUC7-like 3 pre-mRNA splicing factor
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of CROP mRNA
CTD
PMID:24690739
NCBI chr10:79,240,050...79,276,555
Ensembl chr10:79,240,563...79,276,538
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Macf1
microtubule-actin crosslinking factor 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of MACF1 mRNA
CTD
PMID:24690739
NCBI chr 5:135,623,734...135,949,097
Ensembl chr 5:135,623,742...135,945,905
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Mad2l1bp
MAD2L1 binding protein
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of MAD2L1BP mRNA
CTD
PMID:24690739
NCBI chr 9:14,832,133...14,836,458
Ensembl chr 9:14,832,132...14,837,447
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Mafb
MAF bZIP transcription factor B
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of MAFB mRNA
CTD
PMID:24690739
NCBI chr 3:148,998,111...149,000,031
Ensembl chr 3:148,998,122...149,000,031
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Maff
MAF bZIP transcription factor F
increases expression
ISO
Disulfiram results in increased expression of MAFF mRNA
CTD
PMID:20566472
NCBI chr 7:110,912,367...110,923,711
Ensembl chr 7:110,912,499...110,923,851
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Mafg
MAF bZIP transcription factor G
increases expression
ISO
Disulfiram results in increased expression of MAFG mRNA
CTD
PMID:20566472
NCBI chr10:105,903,307...105,911,808
Ensembl chr10:105,903,237...105,912,026
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Mafk
MAF bZIP transcription factor K
increases expression
ISO
Disulfiram results in increased expression of MAFK mRNA
CTD
PMID:20566472
NCBI chr12:14,834,628...14,856,414
Ensembl chr12:14,833,984...14,837,048 Ensembl chr12:14,833,984...14,837,048
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Magoh
mago homolog, exon junction complex subunit
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of MAGOH mRNA
CTD
PMID:24690739
NCBI chr 5:122,639,268...122,646,650
Ensembl chr 5:122,639,308...122,646,617
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Man1b1
mannosidase, alpha, class 1B, member 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of MAN1B1 mRNA
CTD
PMID:24690739
NCBI chr 3:8,143,877...8,165,007
Ensembl chr 3:8,143,381...8,165,006
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Maoa
monoamine oxidase A
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of MAOA mRNA
CTD
PMID:24690739
NCBI chr X:6,032,172...6,098,308
Ensembl chr X:6,030,795...6,099,593
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Map1lc3b
microtubule-associated protein 1 light chain 3 beta
multiple interactions increases expression
ISO
[Disulfiram binds to Copper] which results in decreased expression of MAP1LC3B mRNA Disulfiram results in increased expression of MAP1LC3B mRNA
CTD
PMID:24690739 PMID:34182011
NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 Ensembl chr16:49,665,791...49,677,690
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Map2k3
mitogen activated protein kinase kinase 3
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of MAP2K3 mRNA
CTD
PMID:24690739
NCBI chr10:45,608,145...45,629,492
Ensembl chr10:45,607,163...45,629,492
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Map3k13
mitogen-activated protein kinase kinase kinase 13
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of MAP3K13 mRNA
CTD
PMID:24690739
NCBI chr11:79,094,087...79,235,181
Ensembl chr11:79,097,247...79,235,181
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Map3k20
mitogen-activated protein kinase kinase kinase 20
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of MAP3K20 mRNA
CTD
PMID:24690739
NCBI chr 3:57,130,539...57,289,943
Ensembl chr 3:57,130,551...57,289,626
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Mapk1
mitogen activated protein kinase 1
multiple interactions
ISO
[Copper co-treated with Disulfiram co-treated with Gemcitabine] results in increased phosphorylation of MAPK1 protein; [Copper co-treated with Disulfiram] results in increased phosphorylation of MAPK1 protein
CTD
PMID:23033007
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk3
mitogen activated protein kinase 3
multiple interactions
ISO
[Copper co-treated with Disulfiram co-treated with Gemcitabine] results in increased phosphorylation of MAPK3 protein; [Copper co-treated with Disulfiram] results in increased phosphorylation of MAPK3 protein
CTD
PMID:23033007
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Mapk8
mitogen-activated protein kinase 8
multiple interactions
EXP ISO
[Disulfiram binds to cupric chloride] which results in increased activity of MAPK8 protein; bathocuproine sulfonate inhibits the reaction [[Disulfiram binds to cupric chloride] which results in increased activity of MAPK8 protein] [Disulfiram binds to Copper] which results in increased phosphorylation of MAPK8 protein
CTD
PMID:11239917 PMID:24690739
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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Mapk9
mitogen-activated protein kinase 9
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased phosphorylation of MAPK9 protein
CTD
PMID:24690739
NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
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Mapre2
microtubule-associated protein, RP/EB family, member 2
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of MAPRE2 mRNA
CTD
PMID:24690739
NCBI chr18:15,028,675...15,169,553
Ensembl chr18:15,029,041...15,168,044
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Mcm2
minichromosome maintenance complex component 2
multiple interactions decreases expression
ISO
cupric chloride promotes the reaction [Disulfiram results in decreased expression of MCM2 mRNA]
CTD
PMID:19789329
NCBI chr 4:121,346,434...121,360,962
Ensembl chr 4:121,346,434...121,360,847
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Mcm5
minichromosome maintenance complex component 5
multiple interactions decreases expression
ISO
cupric chloride promotes the reaction [Disulfiram results in decreased expression of MCM5 mRNA]
CTD
PMID:19789329
NCBI chr19:13,483,030...13,504,389
Ensembl chr19:13,483,066...13,504,389
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Me1
malic enzyme 1
increases expression
ISO
Disulfiram results in increased expression of ME1 mRNA
CTD
PMID:20566472
NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304
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Mfsd3
major facilitator superfamily domain containing 3
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of MFSD3 mRNA
CTD
PMID:24690739
NCBI chr 7:108,419,644...108,423,469
Ensembl chr 7:108,421,350...108,423,461
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Mgmt
O-6-methylguanine-DNA methyltransferase
multiple interactions increases degradation decreases activity
ISO EXP
[Disulfiram binds to Copper] which results in decreased expression of and results in decreased activity of MGMT protein; [Disulfiram co-treated with cupric chloride] affects the expression of and affects the activity of MGMT protein; bortezomib inhibits the reaction [Disulfiram results in increased degradation of MGMT protein]; Disulfiram inhibits the reaction [O(6)-benzylguanine binds to MGMT protein]; Disulfiram results in decreased expression of and results in decreased activity of MGMT protein Disulfiram results in decreased activity of MGMT protein
CTD
PMID:24193513
NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756
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Mgst1
microsomal glutathione S-transferase 1
increases expression
ISO
Disulfiram results in increased expression of MGST1 mRNA
CTD
PMID:20566472
NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892
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Midn
midnolin
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of MIDN mRNA
CTD
PMID:24690739
NCBI chr 7:9,548,100...9,559,605
Ensembl chr 7:9,549,650...9,559,752
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Mif
macrophage migration inhibitory factor
increases expression
ISO
Disulfiram results in increased expression of MIF protein
CTD
PMID:34182011
NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504 Ensembl chr 4:12,790,902...12,799,504
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Mix23
mitochondrial matrix import factor 23
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of MIX23 mRNA
CTD
PMID:24690739
NCBI chr11:64,660,711...64,681,000
Ensembl chr11:64,660,711...64,681,000
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Mmp10
matrix metallopeptidase 10
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of MMP10 mRNA
CTD
PMID:24690739
NCBI chr 8:4,689,840...4,697,748
Ensembl chr 8:4,689,840...4,697,748
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Mmp2
matrix metallopeptidase 2
decreases expression
ISO
Disulfiram results in decreased expression of MMP2
CTD
PMID:18047805
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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Mmp3
matrix metallopeptidase 3
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of MMP3 mRNA
CTD
PMID:24690739
NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961
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Mmp9
matrix metallopeptidase 9
decreases expression
ISO
Disulfiram results in decreased expression of MMP9
CTD
PMID:18047805
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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Mppe1
metallophosphoesterase 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of MPPE1 mRNA
CTD
PMID:24690739
NCBI chr18:60,763,418...60,781,553
Ensembl chr18:60,763,419...60,781,553
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Mrpl10
mitochondrial ribosomal protein L10
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of MRPL10 mRNA
CTD
PMID:24690739
NCBI chr10:82,026,031...82,034,451
Ensembl chr10:82,026,031...82,034,443
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Mrpl18
mitochondrial ribosomal protein L18
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of MRPL18 mRNA
CTD
PMID:24690739
NCBI chr 1:47,837,169...47,841,987
Ensembl chr 1:47,836,561...47,841,987
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Mrpl45
mitochondrial ribosomal protein L45
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of MRPL45 mRNA
CTD
PMID:24690739
NCBI chr10:82,308,650...82,320,474
Ensembl chr10:82,308,427...82,320,474
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Mst1
macrophage stimulating 1
increases expression
ISO
Disulfiram results in increased expression of MST1 mRNA
CTD
PMID:34182011
NCBI chr 8:108,767,886...108,773,425
Ensembl chr 8:108,768,839...108,773,416
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Mt-co1
mitochondrially encoded cytochrome c oxidase I
affects activity affects expression
EXP
Disulfiram affects the activity of COX1 protein Disulfiram affects the expression of COX1 mRNA
CTD
PMID:17936468
NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
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Mt1
metallothionein 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of MT1A mRNA
CTD
PMID:24690739
NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049 Ensembl chr17:10,826,032...10,827,049 Ensembl chr X:10,826,032...10,827,049
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Mt2A
metallothionein 2A
increases expression multiple interactions
ISO
Disulfiram results in increased expression of MT2A mRNA cupric chloride promotes the reaction [Disulfiram results in increased expression of MT2A mRNA]; MTF1 protein affects the reaction [Disulfiram results in increased expression of MT2A mRNA]
CTD
PMID:19789329 PMID:32661532
NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
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Mt3
metallothionein 3
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of MT3 mRNA
CTD
PMID:24690739
NCBI chr19:10,848,754...10,850,158
Ensembl chr19:10,848,755...10,850,158
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Mtf1
metal-regulatory transcription factor 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of MTF1 mRNA; MTF1 protein affects the reaction [Disulfiram results in increased expression of ATF3 mRNA]; MTF1 protein affects the reaction [Disulfiram results in increased expression of HMOX1 mRNA]; MTF1 protein affects the reaction [Disulfiram results in increased expression of MT1M mRNA]; MTF1 protein affects the reaction [Disulfiram results in increased expression of MT2A mRNA]
CTD
PMID:24690739 PMID:32661532
NCBI chr 5:137,062,319...137,107,136
Ensembl chr 5:137,062,376...137,107,136
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Mx1
MX dynamin like GTPase 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of MX1 mRNA
CTD
PMID:24690739
NCBI chr11:36,799,659...36,825,209
Ensembl chr11:36,799,660...36,823,507
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Myc
MYC proto-oncogene, bHLH transcription factor
decreases expression
ISO
Disulfiram results in decreased expression of MYC mRNA
CTD
PMID:34182011
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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Mylip
myosin regulatory light chain interacting protein
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of MYLIP mRNA
CTD
PMID:24690739
NCBI chr17:19,286,649...19,308,295
Ensembl chr17:19,286,650...19,308,295
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Mylk
myosin light chain kinase
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of MYLK mRNA
CTD
PMID:24690739
NCBI chr11:65,783,008...66,030,239
Ensembl chr11:65,783,008...66,030,261
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Nat14
N-acetyltransferase 14
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of NAT14 mRNA
CTD
PMID:24690739
NCBI chr 1:68,910,599...68,913,452
Ensembl chr 1:68,910,601...68,912,733
G
Nceh1
neutral cholesterol ester hydrolase 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of NCEH1 mRNA
CTD
PMID:24690739
NCBI chr 2:110,074,985...110,135,592
Ensembl chr 2:110,074,957...110,135,588
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Ncoa7
nuclear receptor coactivator 7
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of NCOA7 mRNA
CTD
PMID:24690739
NCBI chr 1:26,856,228...27,016,950
Ensembl chr 1:26,856,530...27,015,871
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Ncstn
nicastrin
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of NCSTN mRNA
CTD
PMID:24690739
NCBI chr13:84,530,442...84,546,454
Ensembl chr13:84,530,440...84,546,454
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Nefh
neurofilament heavy chain
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of NEFH mRNA
CTD
PMID:24690739
NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351
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Nfe2l3
NFE2 like bZIP transcription factor 3
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of NFE2L3 mRNA
CTD
PMID:24690739
NCBI chr 4:80,506,756...80,534,629
Ensembl chr 4:80,506,756...80,534,629
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Nfkb1
nuclear factor kappa B subunit 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of NFKB1 mRNA
CTD
PMID:24690739
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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Nfkbia
NFKB inhibitor alpha
decreases degradation multiple interactions
EXP ISO
Disulfiram results in decreased degradation of NFKBIA protein [Disulfiram binds to Copper] which results in increased expression of NFKBIA protein
CTD
PMID:10418820 PMID:24690739
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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Nfkbib
NFKB inhibitor beta
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of NFKBIB protein
CTD
PMID:24690739
NCBI chr 1:84,046,292...84,053,862
Ensembl chr 1:84,046,295...84,053,862
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Ngdn
neuroguidin
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of NGDN mRNA
CTD
PMID:24690739
NCBI chr15:28,489,950...28,497,286
Ensembl chr15:28,490,040...28,519,654
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Niban1
niban apoptosis regulator 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of NIBAN1 mRNA
CTD
PMID:24690739
NCBI chr13:63,674,240...63,827,748
Ensembl chr13:63,674,171...63,827,729
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Nol12
nucleolar protein 12
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of NOL12 mRNA
CTD
PMID:24690739
NCBI chr 7:110,493,294...110,498,908
Ensembl chr 7:110,493,246...110,498,907
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Nos2
nitric oxide synthase 2
affects expression
EXP
Disulfiram affects the expression of NOS2 mRNA
CTD
PMID:17936468
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Nosip
nitric oxide synthase interacting protein
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of NOSIP mRNA
CTD
PMID:24690739
NCBI chr 1:95,543,329...95,559,101
Ensembl chr 1:95,543,360...95,558,650
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Npepl1
aminopeptidase-like 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of NPEPL1 mRNA
CTD
PMID:24690739
NCBI chr 3:162,893,932...162,906,491
Ensembl chr 3:162,893,943...162,906,492
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Nppb
natriuretic peptide B
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of NPPB mRNA
CTD
PMID:24690739
NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
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Nptx2
neuronal pentraxin 2
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of NPTX2 mRNA
CTD
PMID:24690739
NCBI chr12:10,037,435...10,048,345
Ensembl chr12:10,037,435...10,048,345
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Nqo1
NAD(P)H quinone dehydrogenase 1
increases expression increases activity
ISO EXP
Disulfiram results in increased expression of NQO1 mRNA Disulfiram results in increased activity of NQO1 protein
CTD
PMID:16045903 PMID:20566472
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
multiple interactions
ISO
Disulfiram binds to and affects the activity of NR1I2 protein Disulfiram binds to and results in increased activity of NR1I2 protein
CTD
PMID:33049310
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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Nrarp
Notch-regulated ankyrin repeat protein
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of NRARP mRNA
CTD
PMID:24690739
NCBI chr 3:7,992,582...7,995,136
Ensembl chr 3:7,992,552...7,995,133
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Nras
NRAS proto-oncogene, GTPase
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of NRAS mRNA
CTD
PMID:24690739
NCBI chr 2:190,582,885...190,593,509
Ensembl chr 2:190,582,918...190,591,626
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Nrp1
neuropilin 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of NRP1 mRNA
CTD
PMID:24690739
NCBI chr19:56,359,455...56,514,628
Ensembl chr19:56,359,455...56,513,633
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Nt5e
5' nucleotidase, ecto
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of NT5E mRNA
CTD
PMID:24690739
NCBI chr 8:89,271,046...89,314,918
Ensembl chr 8:89,270,696...89,314,881
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Nubp1
NUBP iron-sulfur cluster assembly factor 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of NUBP1 mRNA
CTD
PMID:24690739
NCBI chr10:5,259,328...5,270,848
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Nxf1
nuclear RNA export factor 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of NXF1 mRNA
CTD
PMID:24690739
NCBI chr 1:205,655,442...205,668,637
Ensembl chr 1:205,655,375...205,668,636
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Nxt2
nuclear transport factor 2-like export factor 2
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of NXT2 mRNA
CTD
PMID:24690739
NCBI chr X:105,855,616...105,862,902
Ensembl chr X:105,855,608...105,862,899
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Oasl
2'-5'-oligoadenylate synthetase-like
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of OASL mRNA
CTD
PMID:24690739
NCBI chr12:41,682,900...41,695,641
Ensembl chr12:41,682,900...41,695,641
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Osmr
oncostatin M receptor
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of OSMR mRNA
CTD
PMID:24690739
NCBI chr 2:55,907,119...55,961,373
Ensembl chr 2:55,907,132...55,961,262
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P3h3
prolyl 3-hydroxylase 3
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of P3H3 mRNA
CTD
PMID:24690739
NCBI chr 4:157,646,242...157,662,035
Ensembl chr 4:157,646,243...157,662,035
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P3h4
prolyl 3-hydroxylase family member 4
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of P3H4 mRNA
CTD
PMID:24690739
NCBI chr10:85,338,158...85,345,108
Ensembl chr10:85,338,161...85,345,093
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Pam
peptidylglycine alpha-amidating monooxygenase
increases activity
EXP
Disulfiram results in increased activity of PAM protein
CTD
PMID:8246921 PMID:10347250
NCBI chr 9:97,998,581...98,271,966
Ensembl chr 9:98,122,916...98,271,965
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Parp1
poly (ADP-ribose) polymerase 1
multiple interactions increases cleavage
ISO
[Copper co-treated with Disulfiram] results in increased cleavage of PARP1 protein; [Disulfiram binds to Copper] which results in increased cleavage of PARP1 protein; [Disulfiram co-treated with cupric chloride] results in increased cleavage of PARP1 protein; Disulfiram promotes the reaction [Carmustine results in increased cleavage of PARP1 protein] Disulfiram results in increased cleavage of PARP1 protein
CTD
PMID:17079463 PMID:19789329 PMID:23033007 PMID:24193513 PMID:24690739 PMID:34182011 More...
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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Pck2
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of PCK2 mRNA
CTD
PMID:24690739
NCBI chr15:29,027,891...29,036,729
Ensembl chr15:29,027,894...29,037,283
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Pcnx4
pecanex 4
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of PCNX4 mRNA
CTD
PMID:24690739
NCBI chr 6:91,125,063...91,170,423
Ensembl chr 6:91,125,063...91,170,439
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Pde5a
phosphodiesterase 5A
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of PDE5A mRNA
CTD
PMID:24690739
NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701
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Pdgfrb
platelet derived growth factor receptor beta
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of PDGFRB mRNA
CTD
PMID:24690739
NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843
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Pdlim5
PDZ and LIM domain 5
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of PDLIM5 mRNA
CTD
PMID:24690739
NCBI chr 2:230,952,251...231,120,329
Ensembl chr 2:230,952,248...231,120,275
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Pdpn
podoplanin
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of PDPN protein [Disulfiram binds to Copper] which results in increased expression of and results in increased phosphorylation of and results in increased ubiquitination of PDPN protein
CTD
PMID:24690739
NCBI chr 5:155,601,691...155,635,656
Ensembl chr 5:155,601,691...155,635,656
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Pdrg1
p53 and DNA damage regulated 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of PDRG1 mRNA
CTD
PMID:24690739
NCBI chr 3:141,477,561...141,483,730
Ensembl chr 3:141,476,501...141,483,858 Ensembl chr 3:141,476,501...141,483,858
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Pgd
phosphogluconate dehydrogenase
increases expression
ISO
Disulfiram results in increased expression of PGD mRNA
CTD
PMID:20566472
NCBI chr 5:159,582,746...159,598,945
Ensembl chr 5:159,561,271...159,742,778
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Phlda2
pleckstrin homology-like domain, family A, member 2
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of PHLDA2 mRNA
CTD
PMID:24690739
NCBI chr 1:198,696,897...198,699,292
Ensembl chr 1:198,696,897...198,697,836
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Phldb2
pleckstrin homology-like domain, family B, member 2
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of PHLDB2 mRNA
CTD
PMID:24690739
NCBI chr11:54,859,173...55,078,212
Ensembl chr11:54,859,135...55,078,467
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Pigq
phosphatidylinositol glycan anchor biosynthesis, class Q
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of PIGQ mRNA
CTD
PMID:24690739
NCBI chr10:14,942,571...14,958,584
Ensembl chr10:14,942,577...14,958,584
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Pik3ip1
phosphoinositide-3-kinase interacting protein 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of PIK3IP1 mRNA
CTD
PMID:24690739
NCBI chr14:78,204,668...78,216,616
Ensembl chr14:78,204,053...78,216,608
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Pip4k2a
phosphatidylinositol-5-phosphate 4-kinase type 2 alpha
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of PIP4K2A mRNA
CTD
PMID:24690739
NCBI chr17:81,496,669...81,668,180
Ensembl chr17:81,496,670...81,668,029
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Plod2
procollagen lysine, 2-oxoglutarate 5-dioxygenase 2
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of PLOD2 mRNA
CTD
PMID:24690739
NCBI chr 8:93,084,548...93,167,255
Ensembl chr 8:93,084,513...93,167,255
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Plpbp
pyridoxal phosphate binding protein
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of PLPBP mRNA
CTD
PMID:24690739
NCBI chr16:65,003,292...65,014,886
Ensembl chr16:65,002,223...65,014,886
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Plscr4
phospholipid scramblase 4
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of PLSCR4 mRNA
CTD
PMID:24690739
NCBI chr 8:92,987,290...93,026,056
Ensembl chr 8:92,987,381...93,026,049
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Plxnb2
plexin B2
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of PLXNB2 mRNA
CTD
PMID:24690739
NCBI chr 7:120,232,276...120,258,385
Ensembl chr 7:120,232,331...120,258,330
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Pmaip1
phorbol-12-myristate-13-acetate-induced protein 1
increases expression
ISO
Disulfiram results in increased expression of PMAIP1 mRNA
CTD
PMID:34182011
NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429
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Pnldc1
PARN like ribonuclease domain containing exonuclease 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of PNLDC1 mRNA
CTD
PMID:24690739
NCBI chr 1:47,843,224...47,861,675
Ensembl chr 1:47,843,224...47,861,674
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Pnma2
PNMA family member 2
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of PNMA2 mRNA
CTD
PMID:24690739
NCBI chr15:41,111,942...41,119,649
Ensembl chr15:41,112,009...41,121,427
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Polr2c
RNA polymerase II subunit C
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of POLR2C mRNA
CTD
PMID:24690739
NCBI chr19:10,158,153...10,164,935
Ensembl chr19:10,157,823...10,164,945
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Polr2m
RNA polymerase II subunit M
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of POLR2M mRNA
CTD
PMID:24690739
NCBI chr 8:72,131,992...72,139,423
Ensembl chr 8:72,131,530...72,243,036
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Pomc
proopiomelanocortin
decreases expression
EXP
Disulfiram results in decreased expression of POMC protein alternative form
CTD
PMID:8246921
NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
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Pop4
POP4 homolog, ribonuclease P/MRP subunit
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of POP4 mRNA
CTD
PMID:24690739
NCBI chr 1:90,960,026...90,968,360
Ensembl chr 1:90,960,022...90,968,443
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Postn
periostin
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of POSTN mRNA
CTD
PMID:24690739
NCBI chr 2:138,527,714...138,559,098
Ensembl chr 2:138,527,696...138,559,099
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Pparg
peroxisome proliferator-activated receptor gamma
affects expression multiple interactions
ISO
Disulfiram affects the expression of PPARG mRNA Disulfiram binds to and results in increased activity of PPARG protein
CTD
PMID:32712770 PMID:33049310
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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Ppia
peptidylprolyl isomerase A
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of PPIA mRNA
CTD
PMID:24690739
NCBI chr14:81,279,292...81,282,960
Ensembl chr14:81,275,091...81,299,601
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Ppp1r15a
protein phosphatase 1, regulatory subunit 15A
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of PPP1R15A mRNA
CTD
PMID:24690739
NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171
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Ppp1r3c
protein phosphatase 1, regulatory subunit 3C
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of PPP1R3C mRNA
CTD
PMID:24690739
NCBI chr 1:234,460,958...234,465,961
Ensembl chr 1:234,460,652...234,465,961
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Ppp2r2b
protein phosphatase 2, regulatory subunit B, beta
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of PPP2R2B mRNA
CTD
PMID:24690739
NCBI chr18:34,653,716...35,080,889
Ensembl chr18:34,653,721...35,081,025
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Prdx1
peroxiredoxin 1
increases expression
ISO
Disulfiram results in increased expression of PRDX1 mRNA; Disulfiram results in increased expression of PRDX1 protein
CTD
PMID:34182011
NCBI chr 5:130,147,258...130,162,856
Ensembl chr 5:130,147,204...130,162,856
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Prok2
prokineticin 2
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of PROK2 mRNA
CTD
PMID:24690739
NCBI chr 4:132,346,681...132,361,754
Ensembl chr 4:132,347,103...132,361,385
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Prss8
serine protease 8
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of PRSS8 mRNA
CTD
PMID:24690739
NCBI chr 1:182,536,229...182,540,745
Ensembl chr 1:182,536,229...182,540,815
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Psat1
phosphoserine aminotransferase 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of PSAT1 mRNA
CTD
PMID:24690739
NCBI chr 1:213,196,709...213,218,564
Ensembl chr 1:213,196,709...213,218,682
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Psmc4
proteasome 26S subunit, ATPase 4
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of PSMC4 mRNA
CTD
PMID:24690739
NCBI chr 1:83,349,127...83,357,497
Ensembl chr 1:83,348,592...83,357,494
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Pspn
persephin
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of PSPN mRNA
CTD
PMID:24690739
NCBI chr 9:1,840,906...1,841,748
Ensembl chr 9:1,840,896...1,854,327
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Pten
phosphatase and tensin homolog
multiple interactions increases expression
ISO
[Copper co-treated with Disulfiram] results in decreased expression of PTEN protein Disulfiram results in increased expression of PTEN mRNA
CTD
PMID:20424113 PMID:34182011
NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838
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Ptges3
prostaglandin E synthase 3
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of PTGES3 mRNA
CTD
PMID:24690739
NCBI chr 7:490,698...507,759
Ensembl chr 7:490,656...508,084
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Ptgr1
prostaglandin reductase 1
increases expression
ISO
Disulfiram results in increased expression of PTGR1 mRNA
CTD
PMID:20566472
NCBI chr 5:73,784,000...73,802,624
Ensembl chr 5:73,784,009...73,802,666
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Ptgs2
prostaglandin-endoperoxide synthase 2
decreases expression
EXP
Disulfiram results in decreased expression of PTGS2 mRNA
CTD
PMID:10418820
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Ptma
prothymosin alpha
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of PTMA mRNA
CTD
PMID:24690739
NCBI chr 9:87,176,251...87,180,333
Ensembl chr 9:87,176,230...87,180,333
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Ptx3
pentraxin 3
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of PTX3 mRNA
CTD
PMID:24690739
NCBI chr 2:150,487,513...150,493,323
Ensembl chr 2:150,487,513...150,493,323
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Rab5c
RAB5C, member RAS oncogene family
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of RAB5C mRNA
CTD
PMID:24690739
NCBI chr10:85,642,553...85,666,142
Ensembl chr10:85,642,809...85,666,103
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Rac1
Rac family small GTPase 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of RAC1 mRNA
CTD
PMID:24690739
NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
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Rai2
retinoic acid induced 2
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of RAI2 mRNA
CTD
PMID:24690739
NCBI chr X:32,948,656...33,011,222
Ensembl chr X:32,948,656...33,011,264
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Ramac
RNA guanine-7 methyltransferase activating subunit
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of RAMAC mRNA
CTD
PMID:24690739
NCBI chr 1:135,708,529...135,714,417
Ensembl chr 1:135,708,535...135,722,151
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Rasa1
RAS p21 protein activator 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of RASA1 mRNA
CTD
PMID:24690739
NCBI chr 2:15,857,704...15,940,757
Ensembl chr 2:15,857,980...15,940,854
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Rasd1
ras related dexamethasone induced 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of RASD1 mRNA
CTD
PMID:24690739
NCBI chr10:44,766,451...44,775,773
Ensembl chr10:44,766,455...44,768,186
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Rasl11b
RAS-like family 11 member B
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of RASL11B mRNA
CTD
PMID:24690739
NCBI chr14:34,014,924...34,019,146
Ensembl chr14:34,014,509...34,019,152
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Rbis
ribosomal biogenesis factor
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of RBIS mRNA
CTD
PMID:24690739
NCBI chr 2:86,981,314...86,997,352
Ensembl chr 2:86,991,315...87,041,339
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Rbm18
RNA binding motif protein 18
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of RBM18 mRNA
CTD
PMID:24690739
NCBI chr 3:19,467,333...19,487,171
Ensembl chr 3:19,467,335...19,487,178
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Rbm48
RNA binding motif protein 48
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of RBM48 mRNA
CTD
PMID:24690739
NCBI chr 4:30,559,063...30,569,409
Ensembl chr 4:30,559,087...30,569,406
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Rep15
RAB15 effector protein
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of REP15 mRNA
CTD
PMID:24690739
NCBI chr 4:179,951,935...179,953,008
Ensembl chr 4:179,951,935...179,953,008
G
Rftn1
raftlin lipid raft linker 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of RFTN1 mRNA
CTD
PMID:24690739
NCBI chr 9:10,804,611...11,002,084
Ensembl chr 9:10,804,611...11,002,084
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Rftn2
raftlin family member 2
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of RFTN2 mRNA
CTD
PMID:24690739
NCBI chr 9:56,651,617...56,707,830
Ensembl chr 9:56,630,460...56,707,810
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Rgcc
regulator of cell cycle
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of RGCC mRNA
CTD
PMID:24690739
NCBI chr15:54,662,483...54,675,320
Ensembl chr15:54,662,483...54,681,141
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Rgs11
regulator of G-protein signaling 11
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of RGS11 mRNA
CTD
PMID:24690739
NCBI chr10:15,222,804...15,231,062
Ensembl chr10:15,222,803...15,231,060
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Rgs16
regulator of G-protein signaling 16
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of RGS16 mRNA
CTD
PMID:24690739
NCBI chr13:65,887,668...65,892,862
Ensembl chr13:65,887,530...65,892,857
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Rgs2
regulator of G-protein signaling 2
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of RGS2 mRNA
CTD
PMID:24690739
NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385
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Rhbdf1
rhomboid 5 homolog 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of RHBDF1 mRNA
CTD
PMID:24690739
NCBI chr10:15,406,832...15,419,765
Ensembl chr10:15,406,859...15,419,763
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Rhbdf2
rhomboid 5 homolog 2
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of RHBDF2 mRNA
CTD
PMID:24690739
NCBI chr10:101,833,157...101,860,283
Ensembl chr10:101,833,157...101,860,283
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Rhob
ras homolog family member B
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of RHOB mRNA
CTD
PMID:24690739
NCBI chr 6:31,363,752...31,365,926
Ensembl chr 6:31,363,548...31,366,108
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Rnf207
ring finger protein 207
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of RNF207 mRNA
CTD
PMID:24690739
NCBI chr 5:162,815,351...162,828,325
Ensembl chr 5:162,815,357...162,828,375
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Rpl23
ribosomal protein L23
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of RPL23 mRNA
CTD
PMID:24690739
NCBI chr10:82,771,878...82,775,840
Ensembl chr10:82,771,538...82,775,870
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Rpl29
ribosomal protein L29
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of RPL29 mRNA
CTD
PMID:24690739
NCBI chr 8:107,068,929...107,070,963
Ensembl chr 8:107,068,480...107,070,914 Ensembl chr12:107,068,480...107,070,914
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Rpl38
ribosomal protein L38
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of RPL38 mRNA
CTD
PMID:24690739
NCBI chr10:99,701,330...99,705,004
Ensembl chr10:99,701,362...99,705,004 Ensembl chr14:99,701,362...99,705,004 Ensembl chr 3:99,701,362...99,705,004 Ensembl chr 2:99,701,362...99,705,004 Ensembl chr16:99,701,362...99,705,004
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Rplp1
ribosomal protein lateral stalk subunit P1
increases expression
ISO
Disulfiram results in increased expression of RPLP1 protein
CTD
PMID:34182011
NCBI chr 8:62,394,008...62,395,341
Ensembl chr 8:62,393,177...62,395,339
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Rps15
ribosomal protein S15
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of RPS15 mRNA
CTD
PMID:24690739
NCBI chr 7:9,416,003...9,417,442
Ensembl chr 7:9,416,004...9,417,450 Ensembl chr 7:9,416,004...9,417,450
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Rps7
ribosomal protein S7
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of RPS7 mRNA
CTD
PMID:24690739
NCBI chr 6:45,266,200...45,271,064
Ensembl chr 6:45,223,980...45,271,145 Ensembl chr 5:45,223,980...45,271,145
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Rrad
RRAD, Ras related glycolysis inhibitor and calcium channel regulator
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of RRAD mRNA
CTD
PMID:24690739
NCBI chr19:354,184...357,424
Ensembl chr19:354,198...357,417
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Rragd
Ras-related GTP binding D
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of RRAGD mRNA
CTD
PMID:24690739
NCBI chr 5:47,373,902...47,409,369
Ensembl chr 5:47,373,463...47,409,356
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Rras
RAS related
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of RRAS mRNA
CTD
PMID:24690739
NCBI chr 1:95,500,582...95,504,362
Ensembl chr 1:95,500,566...95,504,357
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Rsad2
radical S-adenosyl methionine domain containing 2
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of RSAD2 mRNA
CTD
PMID:24690739
NCBI chr 6:43,046,514...43,059,737
Ensembl chr 6:43,047,658...43,059,699
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RT1-CE5
RT1 class I, locus CE5
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of HLA-F mRNA
CTD
PMID:24690739
NCBI chr20:3,403,418...3,479,476
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Runx2
RUNX family transcription factor 2
increases expression
EXP
Disulfiram results in increased expression of RUNX2 mRNA
CTD
PMID:24496638
NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
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Rybp
RING1 and YY1 binding protein
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of RYBP mRNA
CTD
PMID:24690739
NCBI chr 4:132,876,260...132,928,328
Ensembl chr 4:132,876,361...132,928,316
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Sap18
Sin3A associated protein 18
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of SAP18 mRNA
CTD
PMID:24690739
NCBI chr15:31,943,228...31,947,534
Ensembl chr15:31,943,230...31,950,038 Ensembl chr10:31,943,230...31,950,038
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Sar1b
secretion associated, Ras related GTPase 1B
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of SAR1B mRNA
CTD
PMID:24690739
NCBI chr10:36,024,415...36,054,069
Ensembl chr10:36,024,382...36,054,066
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Sat1
spermidine/spermine N1-acetyl transferase 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of SAT1 mRNA
CTD
PMID:24690739
NCBI chr X:40,158,354...40,161,641
Ensembl chr X:40,157,046...40,196,813
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Sbds
Sbds, ribosome maturation factor
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of SBDS mRNA
CTD
PMID:24690739
NCBI chr12:26,420,410...26,429,650
Ensembl chr12:26,420,414...26,429,649
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Scarf2
scavenger receptor class F, member 2
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of SCARF2 mRNA
CTD
PMID:24690739
NCBI chr11:83,175,956...83,187,415
Ensembl chr11:83,175,963...83,187,348
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Sec61b
SEC61 translocon subunit beta
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of SEC61B mRNA
CTD
PMID:24690739
NCBI chr 5:61,773,594...61,781,804
Ensembl chr 5:61,773,594...61,781,804
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Sel1l3
SEL1L family member 3
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of SEL1L3 mRNA
CTD
PMID:24690739
NCBI chr14:57,775,515...57,882,076
Ensembl chr14:57,775,501...57,882,644
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Sem1
SEM1 26S proteasome subunit
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of SEM1 mRNA
CTD
PMID:24690739
NCBI chr 4:34,671,848...34,692,005
Ensembl chr 4:34,671,848...34,692,005
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Sertad1
SERTA domain containing 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of SERTAD1 mRNA
CTD
PMID:24690739
NCBI chr 1:82,775,692...82,778,961
Ensembl chr 1:82,775,252...82,779,091
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Sf3b4
splicing factor 3B subunit 4
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of SF3B4 mRNA
CTD
PMID:24690739
NCBI chr 2:183,732,791...183,737,545
Ensembl chr 2:183,732,754...183,737,959
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Sgta
small glutamine rich tetratricopeptide repeat co-chaperone alpha
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of SGTA mRNA
CTD
PMID:24690739
NCBI chr 7:8,653,681...8,670,460
Ensembl chr 7:8,653,778...8,670,458
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Sh3pxd2a
SH3 and PX domains 2A
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of SH3PXD2A mRNA
CTD
PMID:24690739
NCBI chr 1:246,153,660...246,359,806
Ensembl chr 1:246,160,502...246,360,166
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Sik1
salt-inducible kinase 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of SIK1 mRNA
CTD
PMID:24690739
NCBI chr20:9,949,407...9,959,036
Ensembl chr20:9,947,396...9,958,991
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Sirt1
sirtuin 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of SIRT1 mRNA
CTD
PMID:24690739
NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
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Sirt6
sirtuin 6
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of SIRT6 mRNA
CTD
PMID:24690739
NCBI chr 7:8,082,312...8,087,776
Ensembl chr 7:8,082,364...8,098,914
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Ski
Ski proto-oncogene
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of SKI mRNA
CTD
PMID:24690739
NCBI chr 5:165,713,525...165,782,134
Ensembl chr 5:165,714,093...165,782,733
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Skil
SKI-like proto-oncogene
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of SKIL mRNA
CTD
PMID:24690739
NCBI chr 2:112,247,047...112,275,176
Ensembl chr 2:112,247,051...112,275,080
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Slc16a10
solute carrier family 16 member 10
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of SLC16A10 mRNA
CTD
PMID:24690739
NCBI chr20:43,454,819...43,567,839
Ensembl chr20:43,459,709...43,567,839
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Slc25a37
solute carrier family 25 member 37
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of SLC25A37 mRNA
CTD
PMID:24690739
NCBI chr15:44,534,280...44,576,697
Ensembl chr15:44,536,727...44,577,199
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Slc30a1
solute carrier family 30 member 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of SLC30A1 mRNA
CTD
PMID:24690739
NCBI chr13:103,491,037...103,494,910
Ensembl chr13:103,491,037...103,494,910
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Slc44a1
solute carrier family 44 member 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of SLC44A1 mRNA
CTD
PMID:24690739
NCBI chr 5:68,061,941...68,241,912
Ensembl chr 5:68,063,618...68,241,909
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Slc44a2
solute carrier family 44 member 2
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of SLC44A2 mRNA
CTD
PMID:24690739
NCBI chr 8:19,870,867...19,905,345
Ensembl chr 8:19,870,888...19,905,342
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Slc6a9
solute carrier family 6 member 9
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of SLC6A9 mRNA
CTD
PMID:24690739
NCBI chr 5:131,374,562...131,408,733
Ensembl chr 5:131,374,542...131,408,728
G
Slc7a1
solute carrier family 7 member 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of SLC7A1 mRNA
CTD
PMID:24690739
NCBI chr12:6,628,288...6,703,849
Ensembl chr12:6,628,007...6,703,849
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Slc7a6os
solute carrier family 7, member 6 opposite strand
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of SLC7A6OS mRNA
CTD
PMID:24690739
NCBI chr19:34,101,978...34,110,666
Ensembl chr19:34,101,982...34,110,651
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Slfn9
schlafen family member 9
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of SLFN11 mRNA
CTD
PMID:24690739
NCBI chr10:67,909,105...67,955,912
Ensembl chr10:67,909,106...67,925,383
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Slu7
SLU7 homolog, splicing factor
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of SLU7 mRNA
CTD
PMID:24690739
NCBI chr10:27,908,325...27,923,784
Ensembl chr10:27,908,396...27,923,349
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Smad3
SMAD family member 3
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of SMAD3 mRNA
CTD
PMID:24690739
NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
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Smox
spermine oxidase
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of SMOX mRNA
CTD
PMID:24690739
NCBI chr 3:118,731,814...118,767,242
Ensembl chr 3:118,731,900...118,765,710 Ensembl chr X:118,731,900...118,765,710
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Snai1
snail family transcriptional repressor 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of SNAI1 mRNA
CTD
PMID:24690739
NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969
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Snip1
Smad nuclear interacting protein 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of SNIP1 mRNA
CTD
PMID:24690739
NCBI chr 5:137,328,371...137,335,846
Ensembl chr 5:137,328,371...137,335,845
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Snrpb2
small nuclear ribonucleoprotein polypeptide B2
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of SNRPB2 mRNA
CTD
PMID:24690739
NCBI chr 3:130,399,239...130,408,821
Ensembl chr 3:130,399,248...130,408,812
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Sod1
superoxide dismutase 1
increases expression decreases activity
ISO
Disulfiram results in increased expression of SOD1 mRNA Disulfiram results in decreased activity of SOD1 protein
CTD
PMID:19016906 PMID:20566472
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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Sod2
superoxide dismutase 2
increases expression multiple interactions
ISO
Disulfiram results in increased expression of SOD2 mRNA [Disulfiram co-treated with Zinc Sulfate] results in increased expression of SOD2 mRNA
CTD
PMID:20566472 PMID:32712770 PMID:34182011
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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Sod3
superoxide dismutase 3
increases expression
ISO
Disulfiram results in increased expression of SOD3 mRNA
CTD
PMID:20566472
NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990
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Sox8
SRY-box transcription factor 8
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of SOX8 mRNA
CTD
PMID:24690739
NCBI chr10:14,584,829...14,589,818
Ensembl chr10:14,584,829...14,589,818
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Spacdr
sperm acrosome developmental regulator
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of SPACDR mRNA
CTD
PMID:24690739
NCBI chr12:18,930,608...18,936,787
Ensembl chr12:18,914,398...18,952,008
G
Spata20
spermatogenesis associated 20
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of SPATA20 mRNA
CTD
PMID:24690739
NCBI chr10:79,427,525...79,435,472
Ensembl chr10:79,427,528...79,434,368
G
Spire1
spire-type actin nucleation factor 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of SPIRE1 mRNA
CTD
PMID:24690739
NCBI chr18:61,041,914...61,171,670
Ensembl chr18:61,041,290...61,171,899
G
Spsb1
splA/ryanodine receptor domain and SOCS box containing 1
increases expression
ISO
Disulfiram results in increased expression of SPSB1 mRNA
CTD
PMID:20566472
NCBI chr 5:160,358,292...160,418,541
Ensembl chr 5:160,358,308...160,418,468
G
Sptbn1
spectrin, beta, non-erythrocytic 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of SPTBN1 mRNA
CTD
PMID:24690739
NCBI chr14:103,841,713...104,016,900
Ensembl chr14:103,842,684...104,008,507
G
Spty2d1
SPT2 chromatin protein domain containing 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of SPTY2D1 mRNA
CTD
PMID:24690739
NCBI chr 1:97,531,495...97,549,616
Ensembl chr 1:97,531,508...97,549,581
G
Sqstm1
sequestosome 1
decreases expression
ISO
Disulfiram results in decreased expression of SQSTM1 protein
CTD
PMID:34182011
NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
G
Srebf1
sterol regulatory element binding transcription factor 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of SREBF1 mRNA
CTD
PMID:24690739
NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
G
Srxn1
sulfiredoxin 1
increases expression
ISO
Disulfiram results in increased expression of SRXN1 mRNA
CTD
PMID:20566472
NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448
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Stc2
stanniocalcin 2
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of STC2 mRNA
CTD
PMID:24690739
NCBI chr10:16,251,046...16,260,815
Ensembl chr10:16,250,853...16,262,973
G
Steep1
STING1 ER exit protein 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of STEEP1 mRNA
CTD
PMID:24690739
NCBI chr X:116,087,626...116,114,159
Ensembl chr X:116,060,929...116,114,159
G
Stx3
syntaxin 3
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of STX3 mRNA
CTD
PMID:24690739
NCBI chr 1:208,617,018...208,686,240
Ensembl chr 1:208,639,115...208,685,805
G
Sulf1
sulfatase 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of SULF1 mRNA; [Disulfiram binds to Copper] which results in increased expression of SULF1 protein
CTD
PMID:24690739
NCBI chr 5:6,362,894...6,526,174
Ensembl chr 5:6,362,911...6,525,584
G
Sumo2
small ubiquitin-like modifier 2
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of SUMO2 mRNA
CTD
PMID:24690739
NCBI chr10:100,771,941...100,784,503
Ensembl chr10:100,686,797...100,784,513 Ensembl chr 5:100,686,797...100,784,513
G
Sun1
Sad1 and UNC84 domain containing 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of SUN1 mRNA
CTD
PMID:24690739
NCBI chr12:15,396,378...15,441,277
Ensembl chr12:15,396,381...15,441,571
G
Sun2
Sad1 and UNC84 domain containing 2
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of SUN2 mRNA
CTD
PMID:24690739
NCBI chr 7:111,275,374...111,292,565
Ensembl chr 7:111,275,380...111,292,553
G
Supt4h1
SPT4 homolog, DSIF elongation factor subunit
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of SUPT4H1 mRNA
CTD
PMID:24690739
NCBI chr10:72,539,323...72,545,582
Ensembl chr10:72,539,382...72,545,831
G
Synj1
synaptojanin 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of SYNJ1 mRNA
CTD
PMID:24690739
NCBI chr11:30,192,629...30,269,447
Ensembl chr11:30,192,629...30,269,220
G
Szrd1
SUZ RNA binding domain containing 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of SZRD1 mRNA
CTD
PMID:24690739
NCBI chr 5:153,418,748...153,443,286
Ensembl chr 5:153,418,748...153,443,252
G
Taf13
TATA-box binding protein associated factor 13
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of TAF13 mRNA
CTD
PMID:24690739
NCBI chr 2:196,205,219...196,215,882
Ensembl chr 2:196,205,243...196,215,878
G
Taf7
TATA-box binding protein associated factor 7
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of TAF7 mRNA
CTD
PMID:24690739
NCBI chr18:29,459,937...29,462,086
Ensembl chr18:29,452,943...29,462,134
G
Tamalin
trafficking regulator and scaffold protein tamalin
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of TAMALIN mRNA
CTD
PMID:24690739
NCBI chr 7:132,338,900...132,359,519
Ensembl chr 7:132,338,900...132,346,666
G
Tanc1
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of TANC1 mRNA
CTD
PMID:24690739
NCBI chr 3:44,099,387...44,335,478
Ensembl chr 3:44,134,016...44,331,627
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Tap2
transporter 2, ATP binding cassette subfamily B member
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of TAP2 mRNA
CTD
PMID:24690739
NCBI chr20:4,636,347...4,650,387
Ensembl chr20:4,636,357...4,650,407
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Tapbp
TAP binding protein
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of TAPBP mRNA
CTD
PMID:24690739
NCBI chr20:4,956,937...4,966,191
Ensembl chr20:4,956,937...4,966,181
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Tat
tyrosine aminotransferase
multiple interactions
EXP
[Ethanol co-treated with Disulfiram] results in increased activity of TAT protein
CTD
PMID:9591243
NCBI chr19:37,947,153...37,957,717
Ensembl chr19:37,947,112...37,958,031
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Tcea2
transcription elongation factor A2
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of TCEA2 mRNA
CTD
PMID:24690739
NCBI chr 3:168,796,244...168,804,125
Ensembl chr 3:168,796,331...168,804,116
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Tcp1
t-complex 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of TCP1 mRNA
CTD
PMID:24690739
NCBI chr 1:47,829,061...47,836,809
Ensembl chr 1:47,828,652...47,836,839
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Tent5b
terminal nucleotidyltransferase 5B
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of TENT5B mRNA
CTD
PMID:24690739
NCBI chr 5:145,695,358...145,702,668
Ensembl chr 5:145,695,362...145,706,073 Ensembl chr11:145,695,362...145,706,073
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Tent5c
terminal nucleotidyltransferase 5C
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of TENT5C mRNA
CTD
PMID:24690739
NCBI chr 2:187,853,026...187,875,260
Ensembl chr 2:187,853,024...187,894,744
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Tfip11
tuftelin interacting protein 11
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of TFIP11 mRNA
CTD
PMID:24690739
NCBI chr12:44,299,619...44,311,851
Ensembl chr12:44,299,622...44,311,855
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Tgfb1
transforming growth factor, beta 1
decreases activity
ISO
Disulfiram results in decreased activity of TGFB1 protein
CTD
PMID:31652400
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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Thap1
THAP domain containing 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of THAP1 mRNA
CTD
PMID:24690739
NCBI chr16:65,905,348...65,909,942
Ensembl chr16:65,904,230...65,909,942
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Them6
thioesterase superfamily member 6
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of THEM6 mRNA
CTD
PMID:24690739
NCBI chr 7:106,606,570...106,609,747
Ensembl chr 7:106,606,570...106,609,746
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Thra
thyroid hormone receptor alpha
multiple interactions
ISO
Disulfiram binds to and results in increased activity of THRA protein
CTD
PMID:33049310
NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
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Ticam2
TIR domain containing adaptor molecule 2
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of TICAM2 mRNA
CTD
PMID:24690739
NCBI chr18:39,289,902...39,311,462
Ensembl chr18:39,294,453...39,311,462
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Tmem167a
transmembrane protein 167A
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of TMEM167A mRNA
CTD
PMID:24690739
NCBI chr 2:21,197,799...21,216,746
Ensembl chr 2:21,197,786...21,212,099
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Tmem175
transmembrane protein 175
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of TMEM175 mRNA
CTD
PMID:24690739
NCBI chr14:1,073,410...1,089,764
Ensembl chr14:1,073,523...1,089,819
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Tmem208
transmembrane protein 208
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of TMEM208 mRNA
CTD
PMID:24690739
NCBI chr19:33,203,587...33,206,287
Ensembl chr19:33,203,587...33,212,183
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Tmem35b
transmembrane protein 35B
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of TMEM35B mRNA
CTD
PMID:24690739
NCBI chr 5:139,446,317...139,449,947
Ensembl chr 5:139,444,399...139,449,947
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Tmem42
transmembrane protein 42
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of TMEM42 mRNA
CTD
PMID:24690739
NCBI chr 8:122,674,793...122,677,290
Ensembl chr 8:122,674,070...122,677,276
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Tmem43
transmembrane protein 43
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of TMEM43 mRNA
CTD
PMID:24690739
NCBI chr 4:123,977,680...123,992,823
Ensembl chr 4:123,977,625...123,992,825
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Tmem44
transmembrane protein 44
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of TMEM44 mRNA
CTD
PMID:24690739
NCBI chr11:70,181,120...70,216,958
Ensembl chr11:70,181,345...70,216,958
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Tnf
tumor necrosis factor
decreases expression multiple interactions increases secretion
EXP ISO
Disulfiram results in decreased expression of TNF mRNA Disulfiram inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased secretion of TNF protein] [Disulfiram co-treated with Zinc Sulfate] inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Disulfiram inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of TNF protein]; Disulfiram promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein] Disulfiram results in increased secretion of TNF protein
CTD
PMID:10418820 PMID:19016906 PMID:32712770 PMID:33851234
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tnfsf10
TNF superfamily member 10
increases expression
ISO
Disulfiram results in increased expression of TNFSF10 mRNA
CTD
PMID:34182011
NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
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Tnip1
TNFAIP3 interacting protein 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of TNIP1 protein
CTD
PMID:24690739
NCBI chr10:39,037,048...39,084,328
Ensembl chr10:39,037,058...39,077,625
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Tnip2
TNFAIP3 interacting protein 2
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of TNIP2 protein
CTD
PMID:24690739
NCBI chr14:76,228,350...76,245,553
Ensembl chr14:76,228,371...76,275,265
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Tns3
tensin 3
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of TNS3 mRNA
CTD
PMID:24690739
NCBI chr14:83,173,649...83,405,671
Ensembl chr14:83,173,649...83,405,998
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Tprkb
Tp53rk binding protein
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of TPRKB mRNA
CTD
PMID:24690739
NCBI chr 4:118,342,910...118,357,908
Ensembl chr 4:118,342,945...118,357,901
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Tpsab1
tryptase alpha/beta 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of TPSAB1 mRNA
CTD
PMID:24690739
NCBI chr10:14,360,396...14,362,811
Ensembl chr10:14,360,396...14,362,811
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Tra2b
transformer 2 beta
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of TRA2B mRNA
CTD
PMID:24690739
NCBI chr11:78,788,880...78,807,252
Ensembl chr11:78,788,884...78,807,249
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Trabd
TraB domain containing
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of TRABD mRNA
CTD
PMID:24690739
NCBI chr 7:120,155,042...120,166,015
Ensembl chr 7:120,155,042...120,166,015
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Trh
thyrotropin releasing hormone
multiple interactions decreases expression increases expression
EXP
Dexamethasone promotes the reaction [Disulfiram results in decreased expression of TRH protein] Disulfiram results in increased expression of TRH mRNA alternative form
CTD
PMID:9681491
NCBI chr 4:124,742,111...124,777,094
Ensembl chr 4:124,742,111...124,744,637
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Tshb
thyroid stimulating hormone subunit beta
multiple interactions decreases secretion
EXP
Dexamethasone promotes the reaction [Disulfiram results in decreased secretion of TSHB protein]
CTD
PMID:9681491
NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559
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Tspyl2
TSPY-like 2
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of TSPYL2 mRNA
CTD
PMID:24690739
NCBI chr X:21,439,478...21,445,208
Ensembl chr X:21,439,478...21,445,089
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Ttc13
tetratricopeptide repeat domain 13
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of TTC13 mRNA
CTD
PMID:24690739
NCBI chr19:52,637,599...52,692,196
Ensembl chr19:52,637,431...52,692,198
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Ttf1
transcription termination factor 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of TTF1 mRNA
CTD
PMID:24690739
NCBI chr 3:12,384,626...12,409,257
Ensembl chr 3:12,384,655...12,409,257
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Tuba4a
tubulin, alpha 4A
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of TUBA4A mRNA
CTD
PMID:24690739
NCBI chr 9:76,709,617...76,714,327
Ensembl chr 9:76,709,614...76,713,918
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Tubb2a
tubulin, beta 2A class IIa
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of TUBB2A mRNA
CTD
PMID:24690739
NCBI chr17:30,796,842...30,800,713
Ensembl chr17:30,747,503...30,800,714
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Tubb2b
tubulin, beta 2B class IIb
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of TUBB2B mRNA
CTD
PMID:24690739
NCBI chr17:30,747,734...30,750,781
Ensembl chr17:30,747,734...30,750,638
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Tubb3
tubulin, beta 3 class III
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of TUBB3 mRNA
CTD
PMID:24690739
NCBI chr19:51,457,187...51,466,243
Ensembl chr19:51,457,184...51,466,243
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Txn2
thioredoxin 2
increases expression
ISO
Disulfiram results in increased expression of TXN2 mRNA
CTD
PMID:20566472
NCBI chr 7:109,496,772...109,510,378
Ensembl chr 7:109,496,761...109,510,359
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Txnl1
thioredoxin-like 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of TXNL1 mRNA
CTD
PMID:24690739
NCBI chr18:57,125,362...57,155,167
Ensembl chr18:57,125,369...57,165,266
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Txnrd1
thioredoxin reductase 1
increases expression
ISO
Disulfiram results in increased expression of TXNRD1 mRNA
CTD
PMID:20566472
NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
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Txnrd2
thioredoxin reductase 2
increases expression
ISO
Disulfiram results in increased expression of TXNRD2 mRNA
CTD
PMID:20566472
NCBI chr11:82,519,996...82,568,156
Ensembl chr11:82,519,999...82,568,156
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Ubfd1
ubiquitin family domain containing 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of UBFD1 mRNA
CTD
PMID:24690739
NCBI chr 1:176,626,003...176,640,993
Ensembl chr 1:176,625,657...176,640,993
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Ugt1a6
UDP glucuronosyltransferase family 1 member A6
increases expression
ISO
Disulfiram results in increased expression of UGT1A6 mRNA
CTD
PMID:20566472
NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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Ulk1
unc-51 like autophagy activating kinase 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of ULK1 mRNA
CTD
PMID:24690739
NCBI chr12:45,851,710...45,877,966
Ensembl chr12:45,851,710...45,877,966
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Uqcc4
ubiquinol-cytochrome c reductase complex assembly factor 4
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of UQCC4 mRNA
CTD
PMID:24690739
NCBI chr10:14,202,217...14,203,519
Ensembl chr10:14,202,243...14,204,029
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Uqcrb
ubiquinol-cytochrome c reductase binding protein
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of UQCRB mRNA
CTD
PMID:24690739
NCBI chr 7:63,814,784...63,820,150
Ensembl chr 7:63,814,797...63,820,150
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Uqcrh
ubiquinol-cytochrome c reductase hinge protein
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of UQCRH mRNA
CTD
PMID:24690739
NCBI chr 5:129,545,978...129,554,173
Ensembl chr 5:129,545,984...129,554,242
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Uspl1
ubiquitin specific peptidase like 1
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of USPL1 mRNA
CTD
PMID:24690739
NCBI chr12:5,823,460...5,850,470
Ensembl chr12:5,823,359...5,850,366
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Utp11
UTP11, small subunit processome component
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of UTP11 mRNA
CTD
PMID:24690739
NCBI chr 5:136,931,279...136,946,164
Ensembl chr 5:136,931,008...136,946,191
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Utp3
UTP3, small subunit processome component
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of UTP3 mRNA
CTD
PMID:24690739
NCBI chr14:19,515,716...19,517,370
Ensembl chr14:19,515,669...19,517,396
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Vcan
versican
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of VCAN mRNA
CTD
PMID:24690739
NCBI chr 2:20,761,718...20,860,637
Ensembl chr 2:20,761,718...20,860,637
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Vcl
vinculin
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of VCL mRNA
CTD
PMID:24690739
NCBI chr15:3,265,776...3,355,586
Ensembl chr15:3,265,815...3,355,606
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Vdac1
voltage-dependent anion channel 1
multiple interactions
ISO
VDAC1 protein results in increased susceptibility to [arsenic trioxide co-treated with Ascorbic Acid co-treated with Disulfiram]
CTD
PMID:24126434
NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640
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Vegfc
vascular endothelial growth factor C
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of VEGFC mRNA
CTD
PMID:24690739
NCBI chr16:37,712,251...37,827,845
Ensembl chr16:37,712,262...37,827,848
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Vgf
VGF nerve growth factor inducible
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of VGF mRNA
CTD
PMID:24690739
NCBI chr12:19,637,313...19,645,123
Ensembl chr12:19,637,320...19,640,341
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Vim
vimentin
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased cleavage of VIM protein
CTD
PMID:24690739
NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
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Vps37b
VPS37B subunit of ESCRT-I
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of VPS37B mRNA
CTD
PMID:24690739
NCBI chr12:32,560,047...32,589,015
Ensembl chr12:32,560,047...32,589,014
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Wdr20
WD repeat domain 20
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of WDR20 mRNA
CTD
PMID:24690739
NCBI chr 6:129,751,952...129,821,464
Ensembl chr 6:129,752,014...129,847,339
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Xylt2
xylosyltransferase 2
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of XYLT2 mRNA
CTD
PMID:24690739
NCBI chr10:79,605,910...79,619,482
Ensembl chr10:79,606,007...79,619,391
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Yju2
YJU2 splicing factor
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of YJU2 mRNA
CTD
PMID:24690739
NCBI chr 9:789,603...799,505
Ensembl chr 9:789,606...799,496
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Zbtb43
zinc finger and BTB domain containing 43
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of ZBTB43 mRNA
CTD
PMID:24690739
NCBI chr 3:16,744,535...16,763,854
Ensembl chr 3:16,744,535...16,763,909
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Zfand2a
zinc finger AN1-type containing 2A
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of ZFAND2A mRNA
CTD
PMID:24690739
NCBI chr12:15,161,601...15,172,679
Ensembl chr12:15,161,639...15,172,677
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Zfp105
zinc finger protein 105
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of ZNF35 mRNA
CTD
PMID:24690739
NCBI chr 8:122,567,229...122,578,696
Ensembl chr 8:122,567,214...122,578,692
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Zfp143
zinc finger protein 143
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of ZNF143 mRNA
CTD
PMID:24690739
NCBI chr 1:164,109,041...164,144,902
Ensembl chr 1:164,109,116...164,144,902
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Zfp217
zinc finger protein 217
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of ZNF217 mRNA
CTD
PMID:24690739
NCBI chr 3:158,890,464...158,931,148
Ensembl chr 3:158,892,265...158,913,040
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Zfp26
zinc finger protein 26
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of ZNF778 mRNA
CTD
PMID:24690739
NCBI chr 8:18,959,656...18,985,647
Ensembl chr 8:18,965,271...18,988,325
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Zfp34
zinc finger protein 34
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of ZNF34 mRNA
CTD
PMID:24690739
NCBI chr 5:157,509,762...157,513,970
Ensembl chr 5:157,509,451...157,599,926
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Zfp36
zinc finger protein 36
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of ZFP36 mRNA
CTD
PMID:24690739
NCBI chr 1:83,669,084...83,671,564
Ensembl chr 1:83,669,084...83,671,564
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Zfp622
zinc finger protein 622
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of ZNF622 mRNA
CTD
PMID:24690739
NCBI chr 2:76,479,605...76,494,405
Ensembl chr 2:76,335,609...76,493,898
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Zfp77
zinc finger protein 77
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of ZNF77 mRNA
CTD
PMID:24690739
NCBI chr 7:7,269,879...7,316,286
Ensembl chr 7:7,269,927...7,286,051
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Zhx3
zinc fingers and homeoboxes 3
multiple interactions
ISO
[Disulfiram binds to Copper] which results in increased expression of ZHX3 mRNA
CTD
PMID:24690739
NCBI chr 3:149,417,787...149,548,671
Ensembl chr 3:149,417,818...149,527,079
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Zkscan5
zinc finger with KRAB and SCAN domains 5
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of ZKSCAN5 mRNA
CTD
PMID:24690739
NCBI chr12:9,384,561...9,405,763
Ensembl chr12:9,384,571...9,405,881
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Zmat2
zinc finger, matrin type 2
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of ZMAT2 mRNA
CTD
PMID:24690739
NCBI chr18:28,409,606...28,414,241
Ensembl chr18:28,398,795...28,414,747
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Zmat5
zinc finger, matrin type 5
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of ZMAT5 mRNA
CTD
PMID:24690739
NCBI chr14:79,568,644...79,599,595
Ensembl chr14:79,568,758...79,599,594
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Znf408
zinc finger protein 408
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of ZNF408 mRNA
CTD
PMID:24690739
NCBI chr 3:77,615,595...77,621,325
Ensembl chr 3:77,616,808...77,621,055
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Zscan26
zinc finger and SCAN domain containing 26
multiple interactions
ISO
[Disulfiram binds to Copper] which results in decreased expression of ZSCAN26 mRNA
CTD
PMID:24690739
NCBI chr17:43,148,063...43,168,070
Ensembl chr17:43,148,079...43,168,070
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