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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:zardaverine
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Accession:CHEBI:46548 term browser browse the term
Definition:A pyridazinone derivative in which pyridazin-3(2H)-one is substituted at C-6 with a 4-(difluoromethoxy)-3-methoxyphenyl group. It is a phosphodiesterase inhibitor, selective for PDE3 and 4.
Synonyms:exact_synonym: 6-[4-(difluoromethoxy)-3-methoxyphenyl]pyridazin-3(2H)-one
 related_synonym: 6-(4-(Difluoromethoxy)-3-methoxyphenyl)-3(2H)-pyridazinone;   6-(4-DIFLUOROMETHOXY-3-METHOXY-PHENYL)-2H-PYRIDAZIN-3-ONE;   Formula=C12H10F2N2O3;   InChI=1S/C12H10F2N2O3/c1-18-10-6-7(2-4-9(10)19-12(13)14)8-3-5-11(17)16-15-8/h2-6,12H,1H3,(H,16,17);   InChIKey=HJMQDJPMQIHLPB-UHFFFAOYSA-N;   SMILES=COc1cc(ccc1OC(F)F)-c1ccc(=O)[nH]n1;   zardaverina;   zardaverinum
 xref: CAS:101975-10-4;   LINCS:LSM-2833
 xref_mesh: MESH:C066436
 xref: PDBeChem:ZAR;   PMID:12387865;   PMID:12952271;   PMID:1426207;   PMID:1648920;   PMID:1665311;   PMID:1700309;   PMID:1723951;   PMID:1787170;   PMID:7644776;   PMID:7684572;   PMID:7925141;   PMID:8035322;   PMID:8369979;   PMID:8381357;   PMID:8392340


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zardaverine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdh2 cadherin 2 decreases localization EXP zardaverine results in decreased localization of CDH2 protein CTD PMID:15082077 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167 		JBrowse link
G Gja1 gap junction protein, alpha 1 decreases localization EXP zardaverine results in decreased localization of GJA1 protein CTD PMID:15082077 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582 		JBrowse link
G Tjp1 tight junction protein 1 decreases localization EXP zardaverine results in decreased localization of TJP1 protein CTD PMID:15082077 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19899
    role 19869
      application 19713
        anti-asthmatic agent 9320
          anti-asthmatic drug 8694
            zardaverine 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19899
    subatomic particle 19897
      composite particle 19897
        hadron 19897
          baryon 19897
            nucleon 19897
              atomic nucleus 19897
                atom 19897
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19776
                        carbon atom 19772
                          organic molecular entity 19772
                            organic molecule 19724
                              organic cyclic compound 19514
                                organic heterocyclic compound 18893
                                  organic heteromonocyclic compound 17817
                                    diazines 13247
                                      pyridazines 137
                                        pyridazinone 122
                                          zardaverine 3
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