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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:zardaverine
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Accession:CHEBI:46548 term browser browse the term
Definition:A pyridazinone derivative in which pyridazin-3(2H)-one is substituted at C-6 with a 4-(difluoromethoxy)-3-methoxyphenyl group. It is a phosphodiesterase inhibitor, selective for PDE3 and 4.
Synonyms:related_synonym: 6-(4-(Difluoromethoxy)-3-methoxyphenyl)-3(2H)-pyridazinone;   6-(4-DIFLUOROMETHOXY-3-METHOXY-PHENYL)-2H-PYRIDAZIN-3-ONE;   6-[4-(difluoromethoxy)-3-methoxyphenyl]pyridazin-3(2H)-one;   zardaverina;   zardaverinum
 xref: CAS:101975-10-4
 xref_mesh: MESH:C066436
 xref: lincs.smallmolecule:LSM-2833;   pdb-ccd:ZAR;   pubmed:12387865;   pubmed:12952271;   pubmed:1426207;   pubmed:1648920;   pubmed:1665311;   pubmed:1700309;   pubmed:1723951;   pubmed:1787170;   pubmed:7644776;   pubmed:7684572;   pubmed:7925141;   pubmed:8035322;   pubmed:8369979;   pubmed:8381357;   pubmed:8392340
 chemrof_formula: C12H10F2N2O3
 chemrof_smiles: COc1cc(-c2ccc(=O)nn2)ccc1OC(F)F
 chemrof_inchikey: HJMQDJPMQIHLPB-UHFFFAOYSA-N
 chemrof_inchi: InChI=1S/C12H10F2N2O3/c1-18-10-6-7(2-4-9(10)19-12(13)14)8-3-5-11(17)16-15-8/h2-6,12H,1H3,(H,16,17)


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zardaverine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1d1 aldo-keto reductase family 1, member D1 decreases activity ISO zardaverine results in decreased activity of AKR1D1 protein CTD PMID:39988211 NCBI chr 4:67,121,288...67,154,543
Ensembl chr 4:67,120,024...67,154,540 		JBrowse link
G Cdh2 cadherin 2 decreases localization EXP zardaverine results in decreased localization of CDH2 protein CTD PMID:15082077 NCBI chr18:8,051,097...8,265,288
Ensembl chr18:8,051,097...8,265,288 		JBrowse link
G Gja1 gap junction protein, alpha 1 decreases localization EXP zardaverine results in decreased localization of GJA1 protein CTD PMID:15082077 NCBI chr20:36,302,490...36,315,010
Ensembl chr20:36,302,352...36,319,689 		JBrowse link
G Tjp1 tight junction protein 1 decreases localization EXP zardaverine results in decreased localization of TJP1 protein CTD PMID:15082077 NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:128,260,330...128,505,158 		JBrowse link
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Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    role 20844
      application 20572
        anti-asthmatic agent 9365
          anti-asthmatic drug 8710
            zardaverine 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      carbon group element atom 20712
                        carbon atom 20706
                          organic molecular entity 20706
                            organic molecule 20499
                              organic cyclic compound 20390
                                organic heterocyclic compound 19381
                                  organic heteromonocyclic compound 18004
                                    diazines 13662
                                      pyridazines 138
                                        pyridazinone 123
                                          zardaverine 4
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