CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: L-tyrosinal
Accession: CHEBI:46209
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Definition: An amino aldehyde that is L-tyrosine in which the carboxy group has undergone formal redution to give the corrresponding aldehyde
Synonyms: exact_synonym: (2S)-2-amino-3-(4-hydroxyphenyl)propanal
related_synonym: (2S)-2-amino-3-(p-hydroxyphenyl)propanal; Formula=C9H11NO2; InChI=1S/C9H11NO2/c10-8(6-11)5-7-1-3-9(12)4-2-7/h1-4,6,8,12H,5,10H2/t8-/m0/s1; InChIKey=DXGAIOIQACHYRK-QMMMGPOBSA-N; L-tyr aldehyde; SMILES=O=C[C@@H](N)CC=1C=CC(=CC1)O; TYROSINAL
alt_id: CHEBI:46188
xref: MetaCyc:CPD-21526; PDBeChem:TYB; PMID:23281040
cyclic_relationship: is_conjugate_base_of CHEBI:141668
G
Comt
catechol-O-methyltransferase
increases methylation decreases activity
ISO
COMT protein results in increased methylation of Methyldopa Methyldopa results in decreased activity of COMT protein
CTD
PMID:7053299 PMID:11160877
NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
G
Gsta1
glutathione S-transferase alpha 1
decreases activity
ISO
Methyldopa analog results in decreased activity of GSTA1 protein
CTD
PMID:8131222
NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
G
Gstm1
glutathione S-transferase mu 1
decreases activity
ISO
Methyldopa analog results in decreased activity of GSTM1 protein
CTD
PMID:8131222
NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
G
Gstp1
glutathione S-transferase pi 1
decreases activity
ISO
Methyldopa analog results in decreased activity of GSTP1 protein
CTD
PMID:8131222
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
G
Prl
prolactin
increases expression increases secretion
ISO
Methyldopa results in increased expression of PRL protein Methyldopa results in increased secretion of PRL protein
CTD
PMID:1867878 PMID:7265421
NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
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Ren
renin
decreases activity
EXP
Methyldopa results in decreased activity of REN protein
CTD
PMID:145319
NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
G
Dpp3
dipeptidylpeptidase 3
increases cleavage multiple interactions
ISO
DPP3 protein results in increased cleavage of Enkephalin, Leucine spinorphin inhibits the reaction [DPP3 protein results in increased cleavage of Enkephalin, Leucine]; tynorphin inhibits the reaction [DPP3 protein results in increased cleavage of Enkephalin, Leucine]
CTD
PMID:10873616
NCBI chr 1:202,204,683...202,228,501
Ensembl chr 1:202,204,693...202,228,541
G
Oprd1
opioid receptor, delta 1
increases activity
ISO
Enkephalin, Leucine results in increased activity of OPRD1 protein
CTD
PMID:26476280
NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
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Oprm1
opioid receptor, mu 1
increases activity
ISO
Enkephalin, Leucine results in increased activity of OPRM1 protein
CTD
PMID:26476280
NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
G
Bax
BCL2 associated X, apoptosis regulator
multiple interactions
ISO
maculosin inhibits the reaction [Diethylnitrosamine results in decreased expression of BAX protein]
CTD
PMID:34726822
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
G
Bcl2
BCL2, apoptosis regulator
multiple interactions
ISO
maculosin inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2 protein]
CTD
PMID:34726822
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
G
Casp3
caspase 3
multiple interactions
ISO
maculosin inhibits the reaction [Diethylnitrosamine results in decreased expression of CASP3 mRNA]; maculosin inhibits the reaction [Diethylnitrosamine results in decreased expression of CASP3 protein]
CTD
PMID:34726822
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
G
Cat
catalase
multiple interactions
ISO
maculosin inhibits the reaction [Diethylnitrosamine results in decreased activity of CAT protein]
CTD
PMID:34726822
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
G
Gsr
glutathione-disulfide reductase
multiple interactions
ISO
maculosin inhibits the reaction [Diethylnitrosamine results in decreased activity of GSR protein]
CTD
PMID:34726822
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
G
Pik3r1
phosphoinositide-3-kinase regulatory subunit 1
multiple interactions
ISO
maculosin inhibits the reaction [Diethylnitrosamine results in increased expression of PIK3R1 protein modified form]
CTD
PMID:34726822
NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631
G
Pten
phosphatase and tensin homolog
multiple interactions
ISO
maculosin inhibits the reaction [Diethylnitrosamine results in decreased expression of PTEN protein]
CTD
PMID:34726822
NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838
G
Tp53
tumor protein p53
multiple interactions
ISO
maculosin inhibits the reaction [Diethylnitrosamine results in decreased expression of TRP53 mRNA]; maculosin inhibits the reaction [Diethylnitrosamine results in decreased expression of TRP53 protein]
CTD
PMID:34726822
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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