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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dimenhydrinate
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Accession:CHEBI:4604 term browser browse the term
Definition:The diphenhydramine salt of 8-chlorotheophylline. Its effects are similar to those of diphenhydramine, but it is less potent. It was thought that by combining the antiemetic effects of diphenhydramine with the mild stimulant effects of 8-chlorotheophyline, the extreme drowsiness induced by the former would be mitigated. However, the sedation caused by diphenhydramine is considerably stronger than the stimulation caused by 8-chlorotheophylline. Dimenhydrinate is used mainly as an antiemetic in the prevention and treatment of motion sickness.
Synonyms:exact_synonym: 2-(diphenylmethoxy)-N,N-dimethylethanaminium 8-chloro-1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydropurin-7-ide
 related_synonym: (O-benzhydryl(dimethylamino)ethanol) 8-chlorotheophyllinate;   8-chloro-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione - 2-(diphenylmethoxy)-N,N-dimethylethanamine (1:1);   Benzhydryl-beta-dimethylaminoethylether 8-chlorotheophylline;   Formula=C24H28ClN5O3;   InChI=1S/C17H21NO.C7H7ClN4O2/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16;1-11-4-3(9-6(8)10-4)5(13)12(2)7(11)14/h3-12,17H,13-14H2,1-2H3;1-2H3,(H,9,10,13);   InChIKey=DKHVTDUUNTVKOW-UHFFFAOYSA-N;   N,N-dimethyl-2-diphenylmethoxyethylamine 8-chlorotheophyllinate;   O-benzhydryldimethylaminoethanol 8-chlorotheophyllinate;   SMILES=Cn1c2nc(Cl)[n-]c2c(=O)n(C)c1=O.C[NH+](C)CCOC(c1ccccc1)c1ccccc1;   beta-dimethylaminoethyl benzhydryl ether 1,3-dimethyl-8-chloroxanthine;   dimenhidrinato;   dimenhydrinatum;   diphenhydramine 8-chlorotheophyllinate;   diphenhydramine 8-chlorotheophylline;   diphenhydramine theoclate
 xref: CAS:523-87-5;   DrugBank:DB00985;   KEGG:D00520
 xref_mesh: MESH:D004111
 xref: Patent:US2499058;   Patent:US2534813



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dimenhydrinate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bche butyrylcholinesterase decreases activity ISO Dimenhydrinate results in decreased activity of BCHE protein CTD PMID:236606 NCBI chr 2:160,607,289...160,699,760 JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Dimenhydrinate inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:50,668,817...50,711,019 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    role 19869
      application 19715
        pharmaceutical 19551
          drug 19551
            antiemetic 5376
              dimenhydrinate 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    main group molecular entity 19835
                      s-block molecular entity 19670
                        hydrogen molecular entity 19652
                          hydrides 19164
                            inorganic hydride 18180
                              pnictogen hydride 18170
                                nitrogen hydride 18083
                                  azane 17892
                                    ammonia 17891
                                      organic amino compound 17891
                                        tertiary amino compound 10161
                                          diphenhydramine 21
                                            dimenhydrinate 2
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