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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:trimethoprim
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Accession:CHEBI:45924 term browser browse the term
Definition:An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge.
Synonyms:exact_synonym: 5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-diamine
 related_synonym: 2,4-diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine;   5-[(3,4,5-trimethoxyphenyl)methyl]-2,4-pyrimidinediamine;   Formula=C14H18N4O3;   InChI=1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18);   InChIKey=IEDVJHCEMCRBQM-UHFFFAOYSA-N;   Proloprim;   SMILES=C=1(CC=2C(=NC(N)=NC2)N)C=C(C(OC)=C(C1)OC)OC;   Trimpex
 alt_id: CHEBI:45921;   CHEBI:9731
 xref: Beilstein:625127;   CAS:738-70-5;   DrugBank:DB00440;   Drug_Central:2755;   Gmelin:808843;   HMDB:HMDB0014583;   KEGG:C01965;   KEGG:D00145;   LINCS:LSM-5246
 xref_mesh: MESH:D014295
 xref: PDBeChem:TOP;   PMID:10423629;   PMID:10969053;   PMID:11051625;   PMID:14629008;   PMID:15203044;   PMID:16311012;   PMID:18816075;   PMID:25111783;   PMID:25361939;   PMID:26546758;   PMID:26566149;   PMID:26942256;   PMID:26987772;   PMID:28166217;   PMID:7602118;   PMID:8911701;   Reaxys:625127;   VSDB:1745;   Wikipedia:Trimethoprim


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trimethoprim term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd74 CD74 molecule affects expression ISO Trimethoprim affects the expression of CD74 mRNA CTD PMID:25811541 NCBI chr18:56,527,071...56,536,406
Ensembl chr18:56,527,132...56,536,410 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases activity 		ISO [Trimethoprim results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Amodiaquine CTD PMID:26599973 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases metabolic processing
decreases activity 		ISO CYP2C8 protein results in increased metabolism of Trimethoprim
Trimethoprim results in decreased activity of CYP2C8 protein 		CTD PMID:12464242 PMID:15570183
G Dhfr dihydrofolate reductase multiple interactions ISO [Trimethoprim results in decreased activity of DHFR protein] which results in increased susceptibility to Valproic Acid CTD PMID:8318756 NCBI chr 2:25,320,895...25,346,004 JBrowse link
G Il6 interleukin 6 multiple interactions ISO [Trimethoprim co-treated with Sulfadiazine] results in increased expression of IL6 protein CTD PMID:10888991 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G RT1-DOb RT1 class II, locus DOb affects expression ISO Trimethoprim affects the expression of HLA-DOB mRNA CTD PMID:25811541 NCBI chr20:4,621,336...4,627,537
Ensembl chr20:4,619,694...4,627,523 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO Trimethoprim inhibits the reaction [SLC22A1 protein results in increased uptake of Quercetin] CTD PMID:24947867 NCBI chr 1:50,624,339...50,651,437
Ensembl chr 1:50,624,377...50,651,436 		JBrowse link
G Slc22a3 solute carrier family 22 member 3 increases transport ISO SLC22A3 protein results in increased transport of Trimethoprim CTD PMID:18253050 NCBI chr 1:50,783,218...50,872,358
Ensembl chr 1:50,783,218...50,872,353 		JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Trimethoprim inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,533,580...46,590,128
Ensembl chr10:46,533,583...46,587,096 		JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Trimethoprim inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,490,262...46,532,954
Ensembl chr10:46,489,831...46,533,425 		JBrowse link
co-trimoxazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ins2 insulin 2 increases secretion ISO Trimethoprim, Sulfamethoxazole Drug Combination results in increased secretion of INS protein modified form CTD PMID:14714756 NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:207,272,742...207,273,805 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      biological role 20818
        xenobiotic 19528
          trimethoprim 11
            5-[(2,4-diaminopyrimidin-5-yl)methyl]-2,3-dimethoxyphenyl group 0
            6-chlorotrimethoprim 0
            6-hydroxytrimethoprim 0
            co-trimoxazole 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    main group molecular entity 20781
                      s-block molecular entity 20574
                        hydrogen molecular entity 20558
                          hydrides 19693
                            inorganic hydride 18602
                              pnictogen hydride 18589
                                nitrogen hydride 18502
                                  azane 18262
                                    ammonia 18261
                                      organic amino compound 18261
                                        aromatic amine 15832
                                          aminopyrimidine 3913
                                            trimethoprim 11
                                              5-[(2,4-diaminopyrimidin-5-yl)methyl]-2,3-dimethoxyphenyl group 0
                                              6-chlorotrimethoprim 0
                                              6-hydroxytrimethoprim 0
                                              co-trimoxazole 1
paths to the root