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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:trans-resveratrol
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Accession:CHEBI:45713 term browser browse the term
Definition:A resveratrol in which the double bond has E configuration.
Synonyms:exact_synonym: 5-[(1E)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol
 related_synonym: (E)-5-(2-(4-hydroxyphenyl)ethenyl)-1,3-benzenediol;   (E)-resveratrol;   3,4',5-stilbenetriol;   3,4',5-trihydroxy-trans-stilbene;   3,4',5-trihydroxystilbene;   5-[(E)-2-(4-hydroxyphenyl)vinyl]benzene-1,3-diol;   Formula=C14H12O3;   InChI=1S/C14H12O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,15-17H/b2-1+;   InChIKey=LUKBXSAWLPMMSZ-OWOJBTEDSA-N;   RESVERATROL;   SMILES=Oc1ccc(cc1)\\C=C\\c1cc(O)cc(O)c1
 alt_id: CHEBI:36000;   CHEBI:45712
 xref: Beilstein:1912434;   CAS:501-36-0;   DrugBank:DB02709;   HMDB:HMDB0003747;   KEGG:C03582;   KNApSAcK:C00002903;   LIPID_MAPS_instance:LMPK13090005
 xref_mesh: MESH:C059514
 xref: MetaCyc:CPD-83;   PDBeChem:STL;   PMID:11408943;   PMID:11414688;   PMID:15492766;   PMID:18261608;   PMID:18616940;   PMID:18789672;   PMID:19046449;   PMID:19084917;   PMID:24345046;   PMID:24467639;   PMID:25172731;   PMID:25308653;   PMID:25624257;   PMID:25643926;   PMID:25684680;   PMID:25704710;   PMID:25724133;   PMID:25762527;   PMID:25814186;   PMID:25841977;   PMID:25937213;   PMID:28094526;   Reaxys:1912434;   Wikipedia:Resveratrol



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(-)-trans-epsilon-viniferin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions
decreases activity
ISO epsilon-viniferin inhibits the reaction [ABCC1 protein results in increased transport of 2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein]
epsilon-viniferin results in decreased activity of ABCC1 protein
CTD PMID:16827148 NCBI chr10:1,022,041...1,162,431
Ensembl chr10:1,038,947...1,162,404
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO epsilon-viniferin inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of AKT1 protein] CTD PMID:34144024 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610
JBrowse link
G Ctsg cathepsin G multiple interactions ISO epsilon-viniferin inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of CTSG protein] CTD PMID:34144024 NCBI chr15:33,901,230...33,907,596
Ensembl chr15:33,901,754...33,907,596
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO epsilon-viniferin results in decreased activity of CYP1A1 protein CTD PMID:12818727 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO epsilon-viniferin results in decreased activity of CYP1A2 protein CTD PMID:12818727 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO epsilon-viniferin results in decreased activity of CYP1B1 protein CTD PMID:12818727 NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 decreases activity ISO epsilon-viniferin results in decreased activity of CYP2B6 protein CTD PMID:12818727 NCBI chr 1:90,780,468...90,859,852 JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO epsilon-viniferin results in decreased activity of CYP2E1 protein CTD PMID:12818727 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity ISO epsilon-viniferin results in decreased activity of CYP3A4 protein CTD PMID:12818727 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857
JBrowse link
G Ldlr low density lipoprotein receptor increases expression ISO epsilon-viniferin results in increased expression of LDLR mRNA CTD PMID:22153697 NCBI chr 8:28,546,191...28,569,075
Ensembl chr 8:28,546,146...28,570,675
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO epsilon-viniferin inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK1 protein] CTD PMID:34144024 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO epsilon-viniferin inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK3 protein] CTD PMID:34144024 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO epsilon-viniferin inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of SRC protein] CTD PMID:34144024 NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:166,511,985...166,559,462
JBrowse link
trans-piceid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 affects export ISO ABCC2 protein affects the export of polydatin CTD PMID:15686436 NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO polydatin inhibits the reaction [potassium oxonate results in increased expression of ABCG2 protein] CTD PMID:22865646 NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:89,005,969...89,132,493
JBrowse link
G Agt angiotensinogen multiple interactions EXP polydatin inhibits the reaction [AGT protein modified form results in increased expression of CYBB mRNA]; polydatin inhibits the reaction [AGT protein modified form results in increased expression of CYBB protein]; polydatin inhibits the reaction [AGT protein modified form results in increased expression of MYH7 mRNA]; polydatin inhibits the reaction [AGT protein modified form results in increased expression of NOX4 mRNA]; polydatin inhibits the reaction [AGT protein modified form results in increased expression of NOX4 protein]; polydatin inhibits the reaction [AGT protein modified form results in increased expression of NPPA mRNA]; polydatin inhibits the reaction [AGT protein modified form results in increased expression of TGFB1 protein] CTD PMID:25488910 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944
JBrowse link
G Ahr aryl hydrocarbon receptor decreases localization
multiple interactions
ISO polydatin results in decreased localization of AHR protein
polydatin promotes the reaction [6-formylindolo(3,2-b)carbazole results in increased localization of AHR protein]
CTD PMID:21756928 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator increases localization ISO polydatin results in increased localization of ARNT protein CTD PMID:21756928 NCBI chr 2:185,686,703...185,745,546
Ensembl chr 2:185,680,683...185,745,546
JBrowse link
G Atg5 autophagy related 5 multiple interactions ISO polydatin inhibits the reaction [Rotenone results in decreased expression of ATG5 protein] CTD PMID:31926197 NCBI chr20:49,380,835...49,471,826
Ensembl chr20:49,380,813...49,471,821
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO cyclopamine inhibits the reaction [polydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of BCL2 mRNA]]; polydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of BCL2 mRNA]
polydatin inhibits the reaction [Dopamine results in decreased expression of BCL2 protein]
CTD PMID:27481074 PMID:28980048 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
JBrowse link
G Cat catalase multiple interactions ISO
EXP
cyclopamine inhibits the reaction [polydatin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in decreased activity of CAT protein]]; polydatin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in decreased activity of CAT protein]
polydatin inhibits the reaction [Arsenic Trioxide results in decreased activity of CAT protein]
CTD PMID:27481074 PMID:29130132 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
decreases expression
decreases secretion
ISO polydatin inhibits the reaction [leptomycin B results in increased secretion of CCL2 protein]; polydatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 mRNA]; polydatin inhibits the reaction [PD168393 results in increased expression of CCL2 mRNA]
polydatin results in decreased expression of CCL2 mRNA
polydatin results in decreased secretion of CCL2 protein
CTD PMID:21756928 PMID:21967610 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO cyclopamine inhibits the reaction [polydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CCND1 mRNA]]; polydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CCND1 mRNA] CTD PMID:27481074 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810
JBrowse link
G Ccnd2 cyclin D2 multiple interactions ISO cyclopamine inhibits the reaction [polydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CCND2 mRNA]]; polydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CCND2 mRNA] CTD PMID:27481074 NCBI chr 4:161,653,048...161,675,422
Ensembl chr 4:161,653,048...161,680,301
Ensembl chr 4:161,653,048...161,680,301
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions
decreases expression
decreases secretion
ISO [polydatin co-treated with TGFA protein] results in increased expression of CXCL10 mRNA; polydatin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein]; polydatin inhibits the reaction [PD168393 results in increased expression of CXCL10 mRNA]
polydatin results in decreased expression of CXCL10 mRNA
polydatin results in decreased secretion of CXCL10 protein
CTD PMID:21756928 PMID:21967610 NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,989,018...15,991,261
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions EXP polydatin inhibits the reaction [AGT protein modified form results in increased expression of CYBB mRNA]; polydatin inhibits the reaction [AGT protein modified form results in increased expression of CYBB protein] CTD PMID:25488910 NCBI chr  X:16,030,596...16,065,065
Ensembl chr  X:16,030,596...16,065,065
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO polydatin results in increased expression of CYP1A1 mRNA CTD PMID:21756928 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO polydatin inhibits the reaction [TGFA protein affects the localization of EGFR protein] CTD PMID:21967610 NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO ESR2 gene mutant form inhibits the reaction [polydatin results in increased expression of SOD2 protein] CTD PMID:24361291 NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase decreases activity ISO polydatin results in decreased activity of G6PD protein CTD PMID:25130191 NCBI chr  X:157,352,364...157,372,144
Ensembl chr  X:157,352,373...157,372,144
JBrowse link
G Gli1 GLI family zinc finger 1 multiple interactions ISO cyclopamine inhibits the reaction [polydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of GLI1 mRNA]]; cyclopamine inhibits the reaction [polydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased localization of GLI1 protein]]; polydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of GLI1 mRNA]; polydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased localization of GLI1 protein] CTD PMID:27481074 NCBI chr 7:65,042,237...65,054,888
Ensembl chr 7:65,042,237...65,054,540
JBrowse link
G Hlcs holocarboxylase synthetase decreases activity ISO polydatin results in decreased activity of HLCS protein CTD PMID:26303405 NCBI chr11:33,455,806...33,635,197
Ensembl chr11:46,925,491...47,105,082
JBrowse link
G Ifng interferon gamma multiple interactions ISO polydatin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; polydatin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; polydatin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; polydatin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein]; polydatin promotes the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL8 protein] CTD PMID:21756928 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP polydatin inhibits the reaction [Arsenic Trioxide results in increased expression of IL1B mRNA] CTD PMID:29130132 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
JBrowse link
G Il4 interleukin 4 multiple interactions EXP polydatin inhibits the reaction [OVAL protein results in increased secretion of IL4 protein] CTD PMID:23840142 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549
JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression
ISO polydatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]
polydatin results in decreased expression of IL6 mRNA
CTD PMID:21756928 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions ISO polydatin inhibits the reaction [Hydrogen Peroxide results in increased expression of KEAP1 protein]
polydatin inhibits the reaction [TSHR protein results in increased expression of KEAP1 protein]
CTD PMID:31705858 NCBI chr 8:28,044,555...28,054,042
Ensembl chr 8:28,044,555...28,054,042
JBrowse link
G Lct lactase increases hydrolysis EXP LCT protein results in increased hydrolysis of polydatin analog CTD PMID:17009167 NCBI chr13:42,334,347...42,376,872
Ensembl chr13:42,334,347...42,376,872
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
increases phosphorylation
ISO polydatin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [polydatin results in increased phosphorylation of MAPK1 protein]
polydatin results in decreased phosphorylation of MAPK1 protein
CTD PMID:21756928 PMID:28980048 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
increases phosphorylation
ISO polydatin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [polydatin results in increased phosphorylation of MAPK3 protein]
polydatin results in decreased phosphorylation of MAPK3 protein
CTD PMID:21756928 PMID:28980048 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
JBrowse link
G Mapk7 mitogen-activated protein kinase 7 multiple interactions
increases phosphorylation
ISO XMD 8-92 inhibits the reaction [polydatin results in increased phosphorylation of MAPK7 protein] CTD PMID:28980048 NCBI chr10:46,170,264...46,176,262
Ensembl chr10:46,669,721...46,675,806
JBrowse link
G Mfn2 mitofusin 2 multiple interactions ISO polydatin inhibits the reaction [Rotenone results in increased expression of MFN2 protein] CTD PMID:31926197 NCBI chr 5:163,587,463...163,617,363
Ensembl chr 5:163,587,463...163,618,495
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO polydatin inhibits the reaction [Rotenone results in increased phosphorylation of MTOR protein] CTD PMID:31926197 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435
JBrowse link
G Myh7 myosin heavy chain 7 multiple interactions EXP polydatin inhibits the reaction [AGT protein modified form results in increased expression of MYH7 mRNA] CTD PMID:25488910 NCBI chr15:32,416,525...32,439,851
Ensembl chr15:32,416,527...32,438,194
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO [polydatin co-treated with Hydrogen Peroxide] results in increased expression of NFE2L2 protein; NFE2L2 protein affects the reaction [[polydatin co-treated with Hydrogen Peroxide] results in increased expression of NFE2L2 protein]; NFE2L2 protein affects the reaction [polydatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of NQO1 protein]]
polydatin inhibits the reaction [TSHR protein results in decreased expression of NFE2L2 protein]
CTD PMID:31705858 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090
JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions EXP polydatin inhibits the reaction [AGT protein modified form results in increased expression of NOX4 mRNA]; polydatin inhibits the reaction [AGT protein modified form results in increased expression of NOX4 protein] CTD PMID:25488910 NCBI chr 1:150,313,736...150,491,480
Ensembl chr 1:150,313,728...150,491,483
JBrowse link
G Nppa natriuretic peptide A multiple interactions EXP polydatin inhibits the reaction [2,2'-dipyridyl disulfide results in increased expression of NPPA protein]; polydatin inhibits the reaction [AGT protein modified form results in increased expression of NPPA mRNA]; polydatin inhibits the reaction [Phenylephrine results in increased expression of NPPA protein] CTD PMID:25449040 PMID:25488910 NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:163,712,184...163,713,493
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO polydatin inhibits the reaction [TSHR protein results in decreased expression of NQO1 protein]
NFE2L2 protein affects the reaction [polydatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of NQO1 protein]]; polydatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of NQO1 protein]
CTD PMID:31705858 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260
JBrowse link
G Orai1 ORAI calcium release-activated calcium modulator 1 affects response to substance ISO ORAI1 protein affects the susceptibility to polydatin CTD PMID:22959927 NCBI chr12:39,195,139...39,209,030
Ensembl chr12:39,195,163...39,209,408
JBrowse link
G Park7 Parkinsonism associated deglycase multiple interactions ISO [PRKN protein affects the susceptibility to polydatin] which results in increased expression of PARK7 protein; polydatin inhibits the reaction [Rotenone results in increased expression of PARK7 protein] CTD PMID:31926197 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:166,636,552...166,659,825
JBrowse link
G Pde5a phosphodiesterase 5A decreases activity ISO polydatin results in decreased activity of PDE5A protein CTD PMID:15769121 NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:213,542,923...213,684,298
JBrowse link
G Ppargc1b PPARG coactivator 1 beta decreases expression ISO polydatin results in decreased expression of PPARGC1B protein CTD PMID:31926197 NCBI chr18:54,758,891...54,861,103
Ensembl chr18:57,029,275...57,131,466
JBrowse link
G Ppp1r12a protein phosphatase 1, regulatory subunit 12A multiple interactions EXP polydatin inhibits the reaction [2,2'-dipyridyl disulfide results in increased phosphorylation of PPP1R12A protein]; polydatin inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R12A protein] CTD PMID:25449040 NCBI chr 7:43,482,808...43,593,689
Ensembl chr 7:45,369,315...45,480,157
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions
affects response to substance
ISO [PRKN protein affects the susceptibility to polydatin] which results in increased expression of PARK7 protein CTD PMID:31926197 NCBI chr 1:51,236,410...52,430,242
Ensembl chr 1:51,210,330...52,430,304
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases activity ISO polydatin results in decreased activity of PTGS1 protein CTD PMID:11962253 NCBI chr 3:39,981,419...40,002,993
Ensembl chr 3:39,981,415...40,002,990
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases activity
ISO [polydatin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of PTGS2 mRNA
polydatin results in decreased activity of PTGS2 protein
CTD PMID:11962253 PMID:21756928 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP
polydatin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; polydatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of RELA protein]
polydatin inhibits the reaction [Arsenic Trioxide results in increased expression of RELA mRNA]
CTD PMID:21756928 PMID:29130132 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817
JBrowse link
G Rhoa ras homolog family member A multiple interactions EXP polydatin inhibits the reaction [Phenylephrine results in increased activity of RHOA protein] CTD PMID:25449040 NCBI chr 8:117,870,548...117,904,303
Ensembl chr 8:117,870,270...117,904,302
JBrowse link
G Shh sonic hedgehog signaling molecule multiple interactions ISO polydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of and results in increased secretion of SHH protein] CTD PMID:27481074 NCBI chr 4:7,687,872...7,697,025
Ensembl chr 4:7,687,846...7,697,901
JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO polydatin inhibits the reaction [Rotenone results in decreased expression of SIRT1 protein] CTD PMID:31926197 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO polydatin inhibits the reaction [potassium oxonate results in decreased expression of SLC22A1 protein] CTD PMID:22865646 NCBI chr 1:50,624,339...50,651,437
Ensembl chr 1:50,624,377...50,651,436
JBrowse link
G Slc22a12 solute carrier family 22 member 12 multiple interactions ISO polydatin inhibits the reaction [potassium oxonate results in increased expression of SLC22A12 protein] CTD PMID:22865646 NCBI chr 1:213,274,266...213,282,793
Ensembl chr 1:213,274,275...213,281,380
JBrowse link
G Slc22a4 solute carrier family 22 member 4 multiple interactions ISO polydatin inhibits the reaction [potassium oxonate results in decreased expression of SLC22A4 protein] CTD PMID:22865646 NCBI chr10:38,133,333...38,179,932
Ensembl chr10:38,634,098...38,679,920
JBrowse link
G Slc22a5 solute carrier family 22 member 5 multiple interactions ISO polydatin inhibits the reaction [potassium oxonate results in decreased expression of SLC22A5 protein] CTD PMID:22865646 NCBI chr10:38,509,072...38,536,240
Ensembl chr10:38,509,072...38,536,077
JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions ISO polydatin inhibits the reaction [potassium oxonate results in decreased expression of SLC22A6 protein] CTD PMID:22865646 NCBI chr 1:214,951,493...214,960,317
Ensembl chr 1:214,951,867...214,960,311
JBrowse link
G Slc2a9 solute carrier family 2 member 9 multiple interactions ISO polydatin inhibits the reaction [potassium oxonate results in increased expression of SLC2A9 protein] CTD PMID:22865646 NCBI chr14:76,540,649...76,674,277
Ensembl chr14:76,540,571...76,674,277
JBrowse link
G Slc5a1 solute carrier family 5 member 1 affects uptake ISO SLC5A1 protein affects the uptake of polydatin CTD PMID:15686436 NCBI chr14:81,778,495...81,843,084
Ensembl chr14:81,778,348...81,846,624
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases expression
ISO polydatin results in increased expression of and results in increased activity of SOD2 protein
ESR2 gene mutant form inhibits the reaction [polydatin results in increased expression of SOD2 protein]; fulvestrant inhibits the reaction [polydatin results in increased expression of SOD2 protein]
CTD PMID:24361291 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO polydatin promotes the reaction [Rotenone results in decreased expression of SQSTM1 protein] CTD PMID:31926197 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:35,026,598...35,037,750
JBrowse link
G Tgfa transforming growth factor alpha multiple interactions ISO [polydatin co-treated with TGFA protein] results in increased expression of CXCL10 mRNA; [polydatin co-treated with TGFA protein] results in increased expression of CXCL8 mRNA; polydatin inhibits the reaction [TGFA protein affects the localization of EGFR protein] CTD PMID:21756928 PMID:21967610 NCBI chr 4:120,175,549...120,258,342
Ensembl chr 4:120,175,593...120,258,339
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP polydatin inhibits the reaction [AGT protein modified form results in increased expression of TGFB1 protein] CTD PMID:25488910 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
ISO
EXP
polydatin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; polydatin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; polydatin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; polydatin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein]; polydatin promotes the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL8 protein]
polydatin results in decreased expression of TNF mRNA
polydatin inhibits the reaction [Arsenic Trioxide results in increased expression of TNF mRNA]
CTD PMID:21756928 PMID:29130132 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP polydatin inhibits the reaction [Arsenic Trioxide results in increased expression of TP53 mRNA] CTD PMID:29130132 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299
JBrowse link
G Tshr thyroid stimulating hormone receptor multiple interactions ISO polydatin inhibits the reaction [TSHR protein results in decreased expression of NFE2L2 protein]; polydatin inhibits the reaction [TSHR protein results in decreased expression of NQO1 protein]; polydatin inhibits the reaction [TSHR protein results in increased expression of KEAP1 protein] CTD PMID:31705858 NCBI chr 6:116,072,321...116,206,009
Ensembl chr 6:116,072,281...116,206,010
JBrowse link
G Tug1 taurine up-regulated 1 decreases expression ISO polydatin results in decreased expression of TUG1 mRNA CTD PMID:30974157 NCBI chr14:78,519,894...78,526,927
Ensembl chr14:82,746,113...82,750,534
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases hydrolysis ISO UGT1A1 protein results in increased hydrolysis of polydatin metabolite CTD PMID:17009167 NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264
JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 multiple interactions ISO polydatin inhibits the reaction [Rotenone results in increased phosphorylation of ULK1 protein] CTD PMID:31926197 NCBI chr12:51,511,492...51,537,746
Ensembl chr12:51,511,492...51,537,746
JBrowse link
G Umod uromodulin multiple interactions ISO polydatin inhibits the reaction [potassium oxonate results in increased expression of and results in decreased secretion of UMOD protein] CTD PMID:22865646 NCBI chr 1:183,247,676...183,261,665
Ensembl chr 1:183,247,674...183,261,030
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      chemical role 20396
        antioxidant 16464
          trans-resveratrol 75
            (+)-trans-epsilon-viniferin 0
            (-)-trans-epsilon-viniferin 13
            (2R,3R)-trans-delta-viniferin 0
            (2R,3S)-trans-epsilon-viniferin 0
            (2S,3R)-trans-epsilon-viniferin 0
            (2S,3S)-trans-delta-viniferin 0
            (E)-trans-miyabenol C 0
            3-methoxy-4',5-dihydroxy-trans-stilbene 0
            4'-O-methyl-trans-resveratrol 0
            resveratrol-3-O-sulfate 0
            trans-diptoindonesin B 0
            trans-piceid 65
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            organic molecule 20654
                              organic cyclic compound 20404
                                organic aromatic compound 20237
                                  phenols 19435
                                    benzenediols 9223
                                      resorcinols 7423
                                        resveratrol 6463
                                          trans-resveratrol 75
                                            (+)-trans-epsilon-viniferin 0
                                            (-)-trans-epsilon-viniferin 13
                                            (2R,3R)-trans-delta-viniferin 0
                                            (2R,3S)-trans-epsilon-viniferin 0
                                            (2S,3R)-trans-epsilon-viniferin 0
                                            (2S,3S)-trans-delta-viniferin 0
                                            (E)-trans-miyabenol C 0
                                            3-methoxy-4',5-dihydroxy-trans-stilbene 0
                                            4'-O-methyl-trans-resveratrol 0
                                            resveratrol-3-O-sulfate 0
                                            trans-diptoindonesin B 0
                                            trans-piceid 65
paths to the root