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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:succinylcholine
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Accession:CHEBI:45652 term browser browse the term
Definition:A quaternary ammonium ion that is the bis-choline ester of succinic acid.
Synonyms:related_synonym: 2,2'-[(1,4-DIOXOBUTANE-1,4-DIYL)BIS(OXY)]BIS(N,N,N-TRIMETHYLETHANAMINIUM);   Dicholine succinate;   Formula=C14H30N2O4;   InChI=1S/C14H30N2O4/c1-15(2,3)9-11-19-13(17)7-8-14(18)20-12-10-16(4,5)6/h7-12H2,1-6H3/q+2;   InChIKey=AXOIZCJOOAYSMI-UHFFFAOYSA-N;   SMILES=C[N+](C)(C)CCOC(=O)CCC(=O)OCC[N+](C)(C)C;   Succinocholine;   Succinoylcholine;   Succinylbischoline;   Succinyldicholine;   Suxamethonium
 alt_id: CHEBI:133060;   CHEBI:45650;   CHEBI:9311
 xref: CAS:306-40-1;   DrugBank:DB00202;   Drug_Central:2489;   HMDB:HMDB0014347;   KEGG:C07546
 xref_mesh: MESH:D013390
 xref: PDBeChem:SCK;   PMID:11123992;   PMID:13063382;   PMID:17667569;   PMID:23223104;   PMID:23838346;   PMID:24018151;   PMID:29368335;   PMID:4032432;   PMID:6196640;   PMID:7526642;   PMID:9435889;   Reaxys:1805311


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succinylcholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bche butyrylcholinesterase increases response to substance
affects response to substance
decreases hydrolysis
decreases abundance
multiple interactions
affects hydrolysis
increases hydrolysis
increases metabolic processing		 ISO BCHE gene mutant form results in increased susceptibility to Succinylcholine; BCHE gene polymorphism results in increased susceptibility to Succinylcholine; BCHE protein mutant form results in increased susceptibility to Succinylcholine
BCHE affects the susceptibility to Succinylcholine; BCHE gene mutant form affects the susceptibility to Succinylcholine; BCHE gene polymorphism affects the susceptibility to Succinylcholine; BCHE protein affects the susceptibility to Succinylcholine
BCHE protein mutant form results in decreased hydrolysis of Succinylcholine
BCHE protein results in decreased abundance of Succinylcholine
[Dichlorvos results in decreased activity of BCHE protein] which results in increased susceptibility to Succinylcholine; Insecticides inhibits the reaction [BCHE protein results in increased metabolism of Succinylcholine]; Organophosphorus Compounds inhibits the reaction [BCHE protein results in increased metabolism of Succinylcholine]; Succinylcholine inhibits the reaction [BCHE protein results in increased hydrolysis of butyrylcholine]
BCHE protein mutant form affects the hydrolysis of Succinylcholine
BCHE protein results in increased hydrolysis of Succinylcholine		 CTD PMID:726855 PMID:900467 PMID:987736 PMID:1058931 PMID:1147298 More... NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions ISO Succinylcholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] CTD PMID:14645658 NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957 		JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions ISO Succinylcholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] CTD PMID:14645658 NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619 		JBrowse link
G Mb myoglobin increases secretion ISO Succinylcholine results in increased secretion of MB protein CTD PMID:8217179 NCBI chr 7:108,759,903...108,767,134
Ensembl chr 7:108,759,904...108,767,383 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      application 19695
        pharmaceutical 19532
          drug 19532
            neuromuscular agent 1322
              succinylcholine 4
                succinylcholine chloride (anhydrous) + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            heteroorganic entity 19512
                              organochalcogen compound 19275
                                organooxygen compound 19191
                                  carbonyl compound 18914
                                    dicarboxylic acids and O-substituted derivatives 11132
                                      dicarboxylic acid 11126
                                        alpha,omega-dicarboxylic acid 3173
                                          succinic acid 712
                                            succinate ester 129
                                              succinylcholine 4
                                                succinylcholine chloride (anhydrous) + 0
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