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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ritonavir
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Accession:CHEBI:45409 term browser browse the term
Definition:An L-valine derivative that is L-valinamide in which alpha-amino group has been acylated by a [(2-isopropyl-1,3-thiazol-4-yl)methyl]methylcarbamoyl group and in which a hydrogen of the carboxamide amino group has been replaced by a (2R,4S,5S)-4-hydroxy-1,6-diphenyl-5-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}hexan-2-yl group. A CYP3A inhibitor and antiretroviral drug from the protease inhibitor class used to treat HIV infection and AIDS, it is often used as a fixed-dose combination with another protease inhibitor, lopinavir. Also used in combination with dasabuvir sodium hydrate, ombitasvir and paritaprevir (under the trade name Viekira Pak) for treatment of chronic hepatitis C virus genotype 1 infection as well as cirrhosis of the liver.
Synonyms:exact_synonym: N-[(2S,4S,5S)-4-hydroxy-1,6-diphenyl-5-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}hexan-2-yl]-N(2)-(methyl{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl}carbamoyl)-L-valinamide
 related_synonym: Formula=C37H48N6O5S2;   InChI=1S/C37H48N6O5S2/c1-24(2)33(42-36(46)43(5)20-29-22-49-35(40-29)25(3)4)34(45)39-28(16-26-12-8-6-9-13-26)18-32(44)31(17-27-14-10-7-11-15-27)41-37(47)48-21-30-19-38-23-50-30/h6-15,19,22-25,28,31-33,44H,16-18,20-21H2,1-5H3,(H,39,45)(H,41,47)(H,42,46)/t28-,31-,32-,33-/m0/s1;   InChIKey=NCDNCNXCDXHOMX-XGKFQTDJSA-N;   SMILES=CC(C)[C@H](NC(=O)N(C)Cc1csc(n1)C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)OCc1cncs1)Cc1ccccc1
 alt_id: CHEBI:8873
 xref: CAS:155213-67-5;   Drug_Central:2391;   HMDB:HMDB0014646;   KEGG:C07240;   KEGG:D00427;   LINCS:LSM-5623
 xref_mesh: MESH:D019438
 xref: PDBeChem:RIT;   PMID:11363086;   PMID:11363184;   PMID:11363300;   PMID:11363329;   PMID:11363397;   PMID:11363517;   PMID:11996889;   PMID:24202050;   PMID:38578027;   PMID:38609668;   PMID:8568292;   PMID:9140265;   PMID:9278209;   PMID:9585800;   Reaxys:768009;   Wikipedia:Ritonavir



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ritonavir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity
multiple interactions
ISO Ritonavir results in decreased activity of ABCB11 protein
Ritonavir inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
CTD PMID:20829430 PMID:22646477 PMID:23956101 PMID:24014644 PMID:28437613 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO hyperforin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]; hypericin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]; kaempferol inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]; Quercetin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir] CTD PMID:15266218 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases expression
decreases activity
ISO Ritonavir results in decreased expression of ABCB4
Ritonavir results in decreased activity of ABCB4 protein
CTD PMID:26626330 PMID:28437613 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
JBrowse link
G Acss2 acyl-CoA synthetase short-chain family member 2 affects expression EXP Ritonavir affects the expression of ACSS2 mRNA CTD PMID:17719200 NCBI chr 3:144,003,808...144,047,452
Ensembl chr 3:144,004,336...144,059,675
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing decreases expression
multiple interactions
ISO Ritonavir results in decreased expression of ADIPOQ mRNA; Ritonavir results in decreased expression of ADIPOQ protein
diphenyleneiodonium inhibits the reaction [Ritonavir results in decreased expression of ADIPOQ protein]
rosiglitazone inhibits the reaction [Ritonavir results in decreased secretion of ADIPOQ protein]
CTD PMID:15865214 PMID:17668557 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation ISO Ritonavir results in increased phosphorylation of AKT1 protein CTD PMID:36198369 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Alb albumin affects binding ISO Ritonavir binds to ALB protein CTD PMID:15814459 PMID:16336266 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO Ritonavir results in increased expression of BAK1 protein CTD PMID:19386116 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Ritonavir results in decreased expression of BCL2 protein CTD PMID:19386116 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO Ritonavir results in decreased expression of BCL2L1 mRNA CTD PMID:16174765 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO Ritonavir results in decreased expression of BIRC5 mRNA; Ritonavir results in decreased expression of BIRC5 protein CTD PMID:16174765 PMID:21270666 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Casp1 caspase 1 decreases expression ISO Ritonavir results in decreased expression of CASP1 protein CTD PMID:10551732 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp3 caspase 3 decreases activity ISO Ritonavir results in decreased activity of CASP3 protein CTD PMID:10551732 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
decreases expression
increases secretion
increases expression
ISO diphenyleneiodonium inhibits the reaction [Ritonavir results in increased expression of CCL2 protein]; Pravastatin inhibits the reaction [Ritonavir results in increased secretion of CCL2 protein]
Ritonavir results in decreased expression of CCL2
CTD PMID:17668557 PMID:20884875 PMID:26626330 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 decreases expression ISO Ritonavir results in decreased expression of CCL20 CTD PMID:26626330 NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 decreases expression
increases expression
ISO Ritonavir results in decreased expression of CCL3
Ritonavir results in increased expression of CCL3 protein
CTD PMID:17668557 PMID:26626330 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression ISO Ritonavir results in decreased expression of CCL4 CTD PMID:26626330 NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231
JBrowse link
G Ccna2 cyclin A2 decreases expression ISO Ritonavir results in decreased expression of CCNA2 mRNA CTD PMID:19386116 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO Ritonavir results in decreased expression of CCNB1 mRNA CTD PMID:19386116 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Ritonavir results in decreased expression of CCND1 protein CTD PMID:16551874 PMID:21270666 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccnd2 cyclin D2 decreases expression ISO Ritonavir results in decreased expression of CCND2 mRNA CTD PMID:16174765 PMID:19386116 NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495
JBrowse link
G Ccne2 cyclin E2 decreases expression ISO Ritonavir results in decreased expression of CCNE2 mRNA CTD PMID:19386116 NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO Ritonavir results in decreased expression of CDK2 mRNA; Ritonavir results in decreased expression of CDK2 protein CTD PMID:16551874 PMID:19386116 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO Ritonavir results in decreased expression of CDK4 mRNA; Ritonavir results in decreased expression of CDK4 protein CTD PMID:16551874 PMID:19386116 NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cdk5 cyclin-dependent kinase 5 decreases expression ISO Ritonavir results in decreased expression of CDK5 mRNA CTD PMID:19386116 NCBI chr 4:10,754,682...10,760,110
Ensembl chr 4:10,754,687...10,760,112
JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases expression ISO Ritonavir results in decreased expression of CDK6 mRNA; Ritonavir results in decreased expression of CDK6 protein CTD PMID:16551874 PMID:19386116 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions
ISO Ritonavir results in increased expression of CDKN1A mRNA; Ritonavir results in increased expression of CDKN1A protein
manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Ritonavir results in increased expression of CDKN1A protein]
CTD PMID:19386116 PMID:20884875 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO Ritonavir results in increased expression of CDKN1B mRNA CTD PMID:19386116 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B increases expression ISO Ritonavir results in increased expression of CDKN2B mRNA CTD PMID:19386116 NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:104,010,680...104,019,050
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions ISO Ritonavir inhibits the reaction [[INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] results in increased expression of CEBPA protein] CTD PMID:11101056 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
JBrowse link
G Ciita class II, major histocompatibility complex, transactivator increases expression ISO Ritonavir results in increased expression of CIITA CTD PMID:26626330 NCBI chr10:5,139,947...5,187,493
Ensembl chr10:5,140,178...5,187,440
JBrowse link
G Crot carnitine O-octanoyltransferase decreases expression EXP Ritonavir results in decreased expression of CROT mRNA CTD PMID:17719200 NCBI chr 4:25,068,270...25,133,111
Ensembl chr 4:25,080,587...25,133,109
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 decreases expression ISO Ritonavir results in decreased expression of CXCL1 CTD PMID:26626330 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 decreases expression ISO Ritonavir results in decreased expression of CXCL10 CTD PMID:26626330 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 decreases expression ISO Ritonavir results in decreased expression of CXCL12 CTD PMID:26626330 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 decreases expression ISO Ritonavir results in decreased expression of CXCL2 CTD PMID:26626330 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 decreases expression ISO Ritonavir results in decreased expression of CXCL1 CTD PMID:26626330 NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Cxcl6 C-X-C motif chemokine ligand 6 decreases expression ISO Ritonavir results in decreased expression of CXCL6 CTD PMID:26626330 NCBI chr14:17,310,790...17,312,250
Ensembl chr14:17,310,426...17,313,093
JBrowse link
G Cyb5r3 cytochrome b5 reductase 3 affects expression EXP Ritonavir affects the expression of CYB5R3 mRNA CTD PMID:17719200 NCBI chr 7:114,306,686...114,324,247
Ensembl chr 7:114,306,685...114,324,298
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
decreases activity
ISO Ritonavir results in increased expression of CYP1A1 mRNA
Ritonavir results in decreased activity of CYP1A1 protein
CTD PMID:11918509 PMID:33814510 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
decreases expression
ISO
EXP
Ritonavir results in increased expression of CYP1A2 mRNA
Ritonavir results in decreased expression of CYP1A2 mRNA
CTD PMID:11918509 PMID:17719200 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Ritonavir results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases activity
increases expression
ISO Ritonavir results in increased activity of CYP2B6 protein
Ritonavir results in increased expression of CYP2B6 protein
CTD PMID:14977870 PMID:26626330 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 increases expression ISO Ritonavir results in increased expression of CYP2C19 mRNA CTD PMID:11918509 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO Ritonavir results in decreased activity of CYP2C8 protein CTD PMID:15601807
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects metabolic processing ISO CYP2D6 protein affects the metabolism of Ritonavir CTD PMID:15286053 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
affects metabolic processing
affects binding
decreases activity
ISO Ritonavir results in increased expression of CYP3A4 mRNA
CYP3A4 protein affects the metabolism of Ritonavir
CYP3A4 protein binds to Ritonavir analog
Ritonavir results in decreased activity of CYP3A4 protein
CTD PMID:15286053 PMID:15523003 PMID:15860655 PMID:16837568 PMID:26626330 More... NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression EXP Ritonavir results in increased expression of CYP3A23-3A1 mRNA CTD PMID:17719200 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 decreases activity ISO Ritonavir results in decreased activity of CYP3A5 protein CTD PMID:15523003 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Cyp4a3 cytochrome P450, family 4, subfamily a, polypeptide 3 decreases expression EXP Ritonavir results in decreased expression of CYP4A3 mRNA CTD PMID:17719200 NCBI chr 5:129,097,571...129,115,488
Ensembl chr 5:129,097,926...129,115,463
JBrowse link
G Cyp4b1 cytochrome P450, family 4, subfamily b, polypeptide 1 affects expression
decreases expression
EXP Ritonavir affects the expression of CYP4B1 mRNA
Ritonavir results in decreased expression of CYP4B1 mRNA
CTD PMID:17719200 NCBI chr 5:129,139,019...129,176,860
Ensembl chr 5:129,139,038...129,156,348
JBrowse link
G Cyp51 cytochrome P450, family 51 increases expression EXP Ritonavir results in increased expression of CYP51 mRNA CTD PMID:17719200 NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression ISO
EXP
Ritonavir results in decreased expression of CYP7A1 mRNA CTD PMID:17719200 PMID:26626330 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 decreases expression ISO
EXP
Ritonavir results in decreased expression of CYP8B1
Ritonavir results in decreased expression of CYP8B1 mRNA
CTD PMID:17719200 PMID:26626330 NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
JBrowse link
G Dhcr7 7-dehydrocholesterol reductase affects expression EXP Ritonavir affects the expression of DHCR7 mRNA CTD PMID:17719200 NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055
JBrowse link
G E2f1 E2F transcription factor 1 decreases expression ISO Ritonavir results in decreased expression of E2F1 mRNA; Ritonavir results in decreased expression of E2F1 protein CTD PMID:19386116 NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361
JBrowse link
G E2f2 E2F transcription factor 2 decreases expression ISO Ritonavir results in decreased expression of E2F2 mRNA CTD PMID:19386116 NCBI chr 5:148,399,193...148,422,595
Ensembl chr 5:148,399,642...148,421,217
JBrowse link
G E2f3 E2F transcription factor 3 decreases expression ISO Ritonavir results in decreased expression of E2F3 mRNA CTD PMID:19386116 NCBI chr17:34,601,756...34,679,139
Ensembl chr17:34,601,830...34,676,253
JBrowse link
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase affects expression EXP Ritonavir affects the expression of EHHADH mRNA CTD PMID:17719200 NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188
JBrowse link
G Esr1 estrogen receptor 1 decreases expression ISO Ritonavir results in decreased expression of ESR1 protein CTD PMID:16551874 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Faslg Fas ligand decreases expression ISO Ritonavir results in decreased expression of FASLG protein CTD PMID:10551732 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fasn fatty acid synthase affects expression EXP Ritonavir affects the expression of FASN mRNA CTD PMID:17719200 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Fgf19 fibroblast growth factor 19 increases expression ISO Ritonavir results in increased expression of FGF19 mRNA CTD PMID:26626330 NCBI chr 1:200,056,526...200,060,980
Ensembl chr 1:200,056,644...200,060,287
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Ritonavir results in increased expression of FOS protein CTD PMID:15504750 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Glb1 galactosidase, beta 1 multiple interactions
increases activity
ISO Acetylcysteine inhibits the reaction [Ritonavir results in increased activity of GLB1 protein]; FTI 277 inhibits the reaction [Ritonavir results in increased activity of GLB1 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Ritonavir results in increased activity of GLB1 protein]; Pravastatin inhibits the reaction [Ritonavir results in increased activity of GLB1 protein] CTD PMID:20884875 NCBI chr 8:114,085,508...114,158,127
Ensembl chr 8:114,085,508...114,158,127
JBrowse link
G Gpd1 glycerol-3-phosphate dehydrogenase 1 multiple interactions ISO Ritonavir promotes the reaction [[INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of GPD1 protein] CTD PMID:11101056 NCBI chr 7:130,842,526...130,851,530
Ensembl chr 7:130,844,138...130,851,529
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Ritonavir results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Ritonavir results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Ritonavir results in increased expression of HMOX1 protein]; Bilirubin inhibits the reaction [Ritonavir results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [Ritonavir results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [Ritonavir results in increased expression of HMOX1 protein]; HMOX1 protein inhibits the reaction [Ritonavir results in increased expression of ICAM1 protein]; NFE2L2 protein mutant form inhibits the reaction [Ritonavir results in increased expression of HMOX1 mRNA]; Ritonavir promotes the reaction [Atazanavir Sulfate results in increased expression of HMOX1 mRNA]; Ritonavir promotes the reaction [HMOX1 protein results in increased chemical synthesis of Bilirubin]; Ritonavir promotes the reaction [Lopinavir results in increased expression of HMOX1 mRNA]; Rotenone inhibits the reaction [Ritonavir results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [Ritonavir results in increased expression of HMOX1 protein]; tricarbonyldichlororuthenium (II) dimer promotes the reaction [Ritonavir results in increased expression of HMOX1 protein]
Ritonavir results in increased expression of HMOX1 mRNA; Ritonavir results in increased expression of HMOX1 protein
CTD PMID:15504750 PMID:26968795 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 affects response to substance ISO HSP90AA1 protein affects the susceptibility to Ritonavir CTD PMID:16551874 NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 increases expression ISO Ritonavir results in increased expression of HSPH1 protein CTD PMID:26626330 NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression
multiple interactions
ISO Ritonavir results in increased expression of ICAM1 protein
HMOX1 protein inhibits the reaction [Ritonavir results in increased expression of ICAM1 protein]
CTD PMID:26968795 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ifng interferon gamma multiple interactions ISO Ritonavir inhibits the reaction [IFNG protein results in increased secretion of TNF protein] CTD PMID:10551732 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
increases secretion
ISO diphenyleneiodonium inhibits the reaction [Ritonavir results in increased expression of IL6 protein]; Pravastatin inhibits the reaction [Ritonavir results in increased secretion of IL6 protein]; Ritonavir inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]
Ritonavir results in increased expression of IL6 mRNA; Ritonavir results in increased expression of IL6 protein
rosiglitazone inhibits the reaction [Ritonavir results in increased expression of IL6 mRNA]
CTD PMID:15388451 PMID:15865214 PMID:17668557 PMID:20884875 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Il7 interleukin 7 decreases expression ISO Ritonavir results in decreased expression of IL7 CTD PMID:26626330 NCBI chr 2:94,235,219...94,280,075
Ensembl chr 2:94,234,766...94,280,075
JBrowse link
G Ins1 insulin 1 multiple interactions ISO Ritonavir inhibits the reaction [[INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] results in increased expression of CEBPA protein]; Ritonavir inhibits the reaction [[INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] results in increased expression of PPARG protein]; Ritonavir promotes the reaction [[INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of GPD1 protein]; Ritonavir promotes the reaction [[INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of SREBF1 protein] CTD PMID:11101056 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO Ritonavir results in increased expression of JUN protein CTD PMID:15504750 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Lep leptin multiple interactions
decreases expression
ISO diphenyleneiodonium inhibits the reaction [Ritonavir results in decreased expression of LEP protein] CTD PMID:17668557 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Lif LIF, interleukin 6 family cytokine decreases expression ISO Ritonavir results in decreased expression of LIF CTD PMID:26626330 NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482
JBrowse link
G Lmna lamin A/C increases expression
increases farnesylation
ISO Ritonavir results in increased expression of LMNA protein
Ritonavir results in increased farnesylation of LMNA protein alternative form
CTD PMID:18230615 PMID:20884875 NCBI chr 2:173,939,751...173,960,423
Ensembl chr 2:173,939,751...173,960,423
JBrowse link
G Lpl lipoprotein lipase affects expression ISO Ritonavir affects the expression of LPL mRNA CTD PMID:11741158 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO Ritonavir results in decreased expression of MYC mRNA CTD PMID:16174765 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression
multiple interactions
ISO Ritonavir results in increased expression of NFE2L2 protein
NFE2L2 protein mutant form inhibits the reaction [Ritonavir results in increased expression of HMOX1 mRNA]
CTD PMID:26968795 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 decreases activity ISO Ritonavir results in decreased activity of NFKB1 protein CTD PMID:16174765 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbia NFKB inhibitor alpha decreases phosphorylation ISO Ritonavir results in decreased phosphorylation of NFKBIA protein CTD PMID:16174765 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nlrc5 NLR family, CARD domain containing 5 decreases expression ISO Ritonavir results in decreased expression of NLRC5 CTD PMID:26626330 NCBI chr19:10,477,638...10,581,023
Ensembl chr19:10,477,628...10,562,121
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
decreases expression
ISO Masoprocol inhibits the reaction [Ritonavir results in decreased expression of NOS3 mRNA] CTD PMID:22037733 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Notch4 notch receptor 4 decreases expression
multiple interactions
EXP Ritonavir results in decreased expression of NOTCH4 protein
[Saquinavir co-treated with Nicotine co-treated with Ritonavir] results in decreased expression of NOTCH4 protein; Vitamin E inhibits the reaction [[Nicotine co-treated with Ritonavir co-treated with Saquinavir] results in decreased expression of NOTCH4 protein]
CTD PMID:20722969 NCBI chr20:4,160,362...4,184,466
Ensembl chr20:4,160,445...4,184,465
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 increases expression ISO Ritonavir increases expression of NR1H3 mRNA in macrophages RGD PMID:18849545 RGD:401842387 NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 increases expression ISO Ritonavir results in increased expression of NR1H4 mRNA CTD PMID:26626330 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity
ISO
EXP
Ritonavir binds to and results in increased activity of NR1I2 protein
Ritonavir results in increased activity of NR1I2 protein
CTD PMID:14977870 PMID:15849716 PMID:27732639 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Ritonavir results in increased cleavage of PARP1 protein CTD PMID:19386116 PMID:21270666 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pon1 paraoxonase 1 decreases activity EXP Ritonavir results in decreased activity of PON1 protein CTD PMID:27378623 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases expression
ISO Ritonavir inhibits the reaction [[INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] results in increased expression of PPARG protein]
Ritonavir results in increased expression of PPARG mRNA
CTD PMID:11101056 PMID:17879945 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Prkca protein kinase C, alpha multiple interactions
increases expression
increases activity
ISO Ritonavir binds to and affects the localization of PRKCA protein
Ritonavir results in increased expression of PRKCA protein
Ritonavir results in increased activity of PRKCA protein
CTD PMID:22020176 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
JBrowse link
G Psma1 proteasome 20S subunit alpha 1 affects expression EXP Ritonavir affects the expression of PSMA1 mRNA CTD PMID:17719200 NCBI chr 1:168,442,421...168,453,440
Ensembl chr 1:168,440,936...168,453,472
JBrowse link
G Psmb3 proteasome 20S subunit beta 3 affects expression EXP Ritonavir affects the expression of PSMB3 mRNA CTD PMID:17719200 NCBI chr10:82,697,425...82,704,521
Ensembl chr10:82,697,425...82,704,521
JBrowse link
G Psmb5 proteasome 20S subunit beta 5 increases expression EXP Ritonavir results in increased expression of PSMB5 mRNA CTD PMID:20213465 NCBI chr15:28,072,772...28,077,367
Ensembl chr15:28,072,781...28,077,440
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation
increases expression
ISO Ritonavir results in decreased phosphorylation of RB1 protein
Ritonavir results in increased expression of RB1 mRNA
CTD PMID:16551874 PMID:19386116 PMID:21270666 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Rbl1 RB transcriptional corepressor like 1 increases expression ISO Ritonavir results in increased expression of RBL1 mRNA CTD PMID:19386116 NCBI chr 3:145,806,160...145,869,434
Ensembl chr 3:145,807,095...145,869,330
JBrowse link
G Rbl2 RB transcriptional corepressor like 2 decreases expression ISO Ritonavir results in decreased expression of RBL2 mRNA CTD PMID:19386116 NCBI chr19:15,876,852...15,923,632
Ensembl chr19:15,876,853...15,923,572
JBrowse link
G Rel REL proto-oncogene, NF-kB subunit decreases activity ISO Ritonavir results in decreased activity of REL protein CTD PMID:16174765 NCBI chr14:97,690,105...97,721,194
Ensembl chr14:97,695,161...97,720,892
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases activity ISO Ritonavir results in decreased activity of RELA protein CTD PMID:16174765 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Scarb1 scavenger receptor class B, member 1 multiple interactions
increases expression
ISO Estradiol inhibits the reaction [Ritonavir results in increased expression of SCARB1 protein]
Ritonavir results in increased expression of SCARB1 mRNA
CTD PMID:17879945 NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647
JBrowse link
G Scp2 sterol carrier protein 2 decreases expression ISO Ritonavir results in decreased expression of SCP2 CTD PMID:26626330 NCBI chr 5:122,806,949...122,881,259
Ensembl chr 5:122,776,549...122,881,287
JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression ISO Ritonavir results in decreased expression of SLC10A1 CTD PMID:26626330 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
JBrowse link
G Slc51a solute carrier family 51 member A decreases expression ISO Ritonavir results in decreased expression of SLC51A CTD PMID:26626330 NCBI chr11:68,299,086...68,313,485
Ensembl chr11:68,299,086...68,313,485
JBrowse link
G Slco4c1 solute carrier organic anion transporter family, member 4C1 multiple interactions ISO Ritonavir inhibits the reaction [SLCO4C1 protein affects the transport of traumatic acid] CTD PMID:39041788 NCBI chr 9:97,177,497...97,229,161
Ensembl chr 9:97,178,861...97,229,715
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase decreases phosphorylation ISO Ritonavir results in decreased phosphorylation of SRC protein CTD PMID:21270666 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO Ritonavir promotes the reaction [[INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of SREBF1 protein] CTD PMID:11101056 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases phosphorylation ISO Ritonavir results in decreased phosphorylation of STAT3 protein CTD PMID:21270666 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tjp1 tight junction protein 1 decreases expression
multiple interactions
EXP Ritonavir results in decreased expression of TJP1 protein
[Saquinavir co-treated with Nicotine co-treated with Ritonavir] results in decreased expression of TJP1 protein; Vitamin E inhibits the reaction [[Nicotine co-treated with Ritonavir co-treated with Saquinavir] results in decreased expression of TJP1 protein]
CTD PMID:20722969 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
JBrowse link
G Tnf tumor necrosis factor decreases secretion
increases expression
multiple interactions
ISO Ritonavir results in decreased secretion of TNF protein
Ritonavir results in increased expression of TNF mRNA; Ritonavir results in increased expression of TNF protein
Ritonavir inhibits the reaction [IFNG protein results in increased secretion of TNF protein]; Ritonavir inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
rosiglitazone inhibits the reaction [Ritonavir results in increased expression of TNF mRNA]
CTD PMID:10551732 PMID:15388451 PMID:15865214 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
ISO FTI 277 inhibits the reaction [Ritonavir results in increased expression of TP53 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Ritonavir results in increased expression of TP53 protein]; Pravastatin inhibits the reaction [Ritonavir results in increased expression of TP53 protein] CTD PMID:19386116 PMID:20884875 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 affects expression ISO Ritonavir affects the expression of UGT1A1 mRNA CTD PMID:15849716 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Zmpste24 zinc metallopeptidase STE24 decreases activity ISO Ritonavir results in decreased activity of ZMPSTE24 protein CTD PMID:18230615 NCBI chr 5:134,627,218...134,660,360
Ensembl chr 5:134,627,229...134,660,110
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    role 19868
      biological role 19866
        xenobiotic 18753
          ritonavir 114
            Kaletra 0
            Paxlovid 0
            Technivie 0
            Viekira Pak 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon atom 19771
                          organic molecular entity 19771
                            heteroorganic entity 19528
                              organochalcogen compound 19290
                                organooxygen compound 19206
                                  carbon oxoacid 18675
                                    carboxylic acid 18672
                                      carboacyl group 17712
                                        univalent carboacyl group 17712
                                          carbamoyl group 17563
                                            carboxamide 17563
                                              monocarboxylic acid amide 15741
                                                urea 6230
                                                  ureas 6228
                                                    ritonavir 114
                                                      Kaletra 0
                                                      Paxlovid 0
                                                      Technivie 0
                                                      Viekira Pak 0
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