CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: ritonavir
Accession: CHEBI:45409
browse the term
Definition: An L-valine derivative that is L-valinamide in which alpha-amino group has been acylated by a [(2-isopropyl-1,3-thiazol-4-yl)methyl]methylcarbamoyl group and in which a hydrogen of the carboxamide amino group has been replaced by a (2R,4S,5S)-4-hydroxy-1,6-diphenyl-5-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}hexan-2-yl group. A CYP3A inhibitor and antiretroviral drug from the protease inhibitor class used to treat HIV infection and AIDS, it is often used as a fixed-dose combination with another protease inhibitor, lopinavir. Also used in combination with dasabuvir sodium hydrate, ombitasvir and paritaprevir (under the trade name Viekira Pak) for treatment of chronic hepatitis C virus genotype 1 infection as well as cirrhosis of the liver.
Synonyms: exact_synonym: N-[(2S,4S,5S)-4-hydroxy-1,6-diphenyl-5-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}hexan-2-yl]-N(2)-(methyl{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl}carbamoyl)-L-valinamide
related_synonym: Formula=C37H48N6O5S2; InChI=1S/C37H48N6O5S2/c1-24(2)33(42-36(46)43(5)20-29-22-49-35(40-29)25(3)4)34(45)39-28(16-26-12-8-6-9-13-26)18-32(44)31(17-27-14-10-7-11-15-27)41-37(47)48-21-30-19-38-23-50-30/h6-15,19,22-25,28,31-33,44H,16-18,20-21H2,1-5H3,(H,39,45)(H,41,47)(H,42,46)/t28-,31-,32-,33-/m0/s1; InChIKey=NCDNCNXCDXHOMX-XGKFQTDJSA-N; SMILES=CC(C)[C@H](NC(=O)N(C)Cc1csc(n1)C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)OCc1cncs1)Cc1ccccc1
alt_id: CHEBI:8873
xref: CAS:155213-67-5; Drug_Central:2391; HMDB:HMDB0014646; KEGG:C07240; KEGG:D00427; LINCS:LSM-5623
xref_mesh: MESH:D019438
xref: PDBeChem:RIT; PMID:11363086; PMID:11363184; PMID:11363300; PMID:11363329; PMID:11363397; PMID:11363517; PMID:11996889; PMID:24202050; PMID:38578027; PMID:38609668; PMID:8568292; PMID:9140265; PMID:9278209; PMID:9585800; Reaxys:768009; Wikipedia:Ritonavir
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Abcb11
ATP binding cassette subfamily B member 11
decreases activity multiple interactions
ISO
Ritonavir results in decreased activity of ABCB11 protein Ritonavir inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
CTD
PMID:20829430 PMID:22646477 PMID:23956101 PMID:24014644 PMID:28437613
NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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Abcb1a
ATP binding cassette subfamily B member 1A
multiple interactions
ISO
hyperforin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]; hypericin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]; kaempferol inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]; Quercetin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]
CTD
PMID:15266218
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Abcb4
ATP binding cassette subfamily B member 4
decreases expression decreases activity
ISO
Ritonavir results in decreased expression of ABCB4 Ritonavir results in decreased activity of ABCB4 protein
CTD
PMID:26626330 PMID:28437613
NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
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Acss2
acyl-CoA synthetase short-chain family member 2
affects expression
EXP
Ritonavir affects the expression of ACSS2 mRNA
CTD
PMID:17719200
NCBI chr 3:144,003,808...144,047,452
Ensembl chr 3:144,004,336...144,059,675
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Adipoq
adiponectin, C1Q and collagen domain containing
decreases expression multiple interactions
ISO
Ritonavir results in decreased expression of ADIPOQ mRNA; Ritonavir results in decreased expression of ADIPOQ protein diphenyleneiodonium inhibits the reaction [Ritonavir results in decreased expression of ADIPOQ protein] rosiglitazone inhibits the reaction [Ritonavir results in decreased secretion of ADIPOQ protein]
CTD
PMID:15865214 PMID:17668557
NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
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Akt1
AKT serine/threonine kinase 1
increases phosphorylation
ISO
Ritonavir results in increased phosphorylation of AKT1 protein
CTD
PMID:36198369
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Alb
albumin
affects binding
ISO
Ritonavir binds to ALB protein
CTD
PMID:15814459 PMID:16336266
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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Bak1
BCL2-antagonist/killer 1
increases expression
ISO
Ritonavir results in increased expression of BAK1 protein
CTD
PMID:19386116
NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
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Bcl2
BCL2, apoptosis regulator
decreases expression
ISO
Ritonavir results in decreased expression of BCL2 protein
CTD
PMID:19386116
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bcl2l1
Bcl2-like 1
decreases expression
ISO
Ritonavir results in decreased expression of BCL2L1 mRNA
CTD
PMID:16174765
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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Birc5
baculoviral IAP repeat-containing 5
decreases expression
ISO
Ritonavir results in decreased expression of BIRC5 mRNA; Ritonavir results in decreased expression of BIRC5 protein
CTD
PMID:16174765 PMID:21270666
NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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Casp1
caspase 1
decreases expression
ISO
Ritonavir results in decreased expression of CASP1 protein
CTD
PMID:10551732
NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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Casp3
caspase 3
decreases activity
ISO
Ritonavir results in decreased activity of CASP3 protein
CTD
PMID:10551732
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Ccl2
C-C motif chemokine ligand 2
multiple interactions decreases expression increases secretion increases expression
ISO
diphenyleneiodonium inhibits the reaction [Ritonavir results in increased expression of CCL2 protein]; Pravastatin inhibits the reaction [Ritonavir results in increased secretion of CCL2 protein] Ritonavir results in decreased expression of CCL2
CTD
PMID:17668557 PMID:20884875 PMID:26626330
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Ccl20
C-C motif chemokine ligand 20
decreases expression
ISO
Ritonavir results in decreased expression of CCL20
CTD
PMID:26626330
NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629
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Ccl3
C-C motif chemokine ligand 3
decreases expression increases expression
ISO
Ritonavir results in decreased expression of CCL3 Ritonavir results in increased expression of CCL3 protein
CTD
PMID:17668557 PMID:26626330
NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
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Ccl4
C-C motif chemokine ligand 4
decreases expression
ISO
Ritonavir results in decreased expression of CCL4
CTD
PMID:26626330
NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231
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Ccna2
cyclin A2
decreases expression
ISO
Ritonavir results in decreased expression of CCNA2 mRNA
CTD
PMID:19386116
NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
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Ccnb1
cyclin B1
decreases expression
ISO
Ritonavir results in decreased expression of CCNB1 mRNA
CTD
PMID:19386116
NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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Ccnd1
cyclin D1
decreases expression
ISO
Ritonavir results in decreased expression of CCND1 protein
CTD
PMID:16551874 PMID:21270666
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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Ccnd2
cyclin D2
decreases expression
ISO
Ritonavir results in decreased expression of CCND2 mRNA
CTD
PMID:16174765 PMID:19386116
NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495
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Ccne2
cyclin E2
decreases expression
ISO
Ritonavir results in decreased expression of CCNE2 mRNA
CTD
PMID:19386116
NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
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Cdk2
cyclin dependent kinase 2
decreases expression
ISO
Ritonavir results in decreased expression of CDK2 mRNA; Ritonavir results in decreased expression of CDK2 protein
CTD
PMID:16551874 PMID:19386116
NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
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Cdk4
cyclin-dependent kinase 4
decreases expression
ISO
Ritonavir results in decreased expression of CDK4 mRNA; Ritonavir results in decreased expression of CDK4 protein
CTD
PMID:16551874 PMID:19386116
NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
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Cdk5
cyclin-dependent kinase 5
decreases expression
ISO
Ritonavir results in decreased expression of CDK5 mRNA
CTD
PMID:19386116
NCBI chr 4:10,754,682...10,760,110
Ensembl chr 4:10,754,687...10,760,112
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Cdk6
cyclin-dependent kinase 6
decreases expression
ISO
Ritonavir results in decreased expression of CDK6 mRNA; Ritonavir results in decreased expression of CDK6 protein
CTD
PMID:16551874 PMID:19386116
NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases expression multiple interactions
ISO
Ritonavir results in increased expression of CDKN1A mRNA; Ritonavir results in increased expression of CDKN1A protein manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Ritonavir results in increased expression of CDKN1A protein]
CTD
PMID:19386116 PMID:20884875
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Cdkn1b
cyclin-dependent kinase inhibitor 1B
increases expression
ISO
Ritonavir results in increased expression of CDKN1B mRNA
CTD
PMID:19386116
NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
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Cdkn2b
cyclin-dependent kinase inhibitor 2B
increases expression
ISO
Ritonavir results in increased expression of CDKN2B mRNA
CTD
PMID:19386116
NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:104,010,680...104,019,050
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Cebpa
CCAAT/enhancer binding protein alpha
multiple interactions
ISO
Ritonavir inhibits the reaction [[INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] results in increased expression of CEBPA protein]
CTD
PMID:11101056
NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
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Ciita
class II, major histocompatibility complex, transactivator
increases expression
ISO
Ritonavir results in increased expression of CIITA
CTD
PMID:26626330
NCBI chr10:5,139,947...5,187,493
Ensembl chr10:5,140,178...5,187,440
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Crot
carnitine O-octanoyltransferase
decreases expression
EXP
Ritonavir results in decreased expression of CROT mRNA
CTD
PMID:17719200
NCBI chr 4:25,068,270...25,133,111
Ensembl chr 4:25,080,587...25,133,109
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Cxcl1
C-X-C motif chemokine ligand 1
decreases expression
ISO
Ritonavir results in decreased expression of CXCL1
CTD
PMID:26626330
NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
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Cxcl10
C-X-C motif chemokine ligand 10
decreases expression
ISO
Ritonavir results in decreased expression of CXCL10
CTD
PMID:26626330
NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
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Cxcl12
C-X-C motif chemokine ligand 12
decreases expression
ISO
Ritonavir results in decreased expression of CXCL12
CTD
PMID:26626330
NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
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Cxcl2
C-X-C motif chemokine ligand 2
decreases expression
ISO
Ritonavir results in decreased expression of CXCL2
CTD
PMID:26626330
NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
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Cxcl3
C-X-C motif chemokine ligand 3
decreases expression
ISO
Ritonavir results in decreased expression of CXCL1
CTD
PMID:26626330
NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
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Cxcl6
C-X-C motif chemokine ligand 6
decreases expression
ISO
Ritonavir results in decreased expression of CXCL6
CTD
PMID:26626330
NCBI chr14:17,310,790...17,312,250
Ensembl chr14:17,310,426...17,313,093
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Cyb5r3
cytochrome b5 reductase 3
affects expression
EXP
Ritonavir affects the expression of CYB5R3 mRNA
CTD
PMID:17719200
NCBI chr 7:114,306,686...114,324,247
Ensembl chr 7:114,306,685...114,324,298
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases expression decreases activity
ISO
Ritonavir results in increased expression of CYP1A1 mRNA Ritonavir results in decreased activity of CYP1A1 protein
CTD
PMID:11918509 PMID:33814510
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
increases expression decreases expression
ISO EXP
Ritonavir results in increased expression of CYP1A2 mRNA Ritonavir results in decreased expression of CYP1A2 mRNA
CTD
PMID:11918509 PMID:17719200
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
decreases activity
ISO
Ritonavir results in decreased activity of CYP1B1 protein
CTD
PMID:33814510
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
increases activity increases expression
ISO
Ritonavir results in increased activity of CYP2B6 protein Ritonavir results in increased expression of CYP2B6 protein
CTD
PMID:14977870 PMID:26626330
NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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Cyp2c6
cytochrome P450, family 2, subfamily C, polypeptide 6
increases expression
ISO
Ritonavir results in increased expression of CYP2C19 mRNA
CTD
PMID:11918509
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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Cyp2c79
cytochrome P450, family 2, subfamily c, polypeptide 79
decreases activity
ISO
Ritonavir results in decreased activity of CYP2C8 protein
CTD
PMID:15601807
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Cyp2d4
cytochrome P450, family 2, subfamily d, polypeptide 4
affects metabolic processing
ISO
CYP2D6 protein affects the metabolism of Ritonavir
CTD
PMID:15286053
NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
increases expression affects metabolic processing affects binding decreases activity
ISO
Ritonavir results in increased expression of CYP3A4 mRNA CYP3A4 protein affects the metabolism of Ritonavir CYP3A4 protein binds to Ritonavir analog Ritonavir results in decreased activity of CYP3A4 protein
CTD
PMID:15286053 PMID:15523003 PMID:15860655 PMID:16837568 PMID:26626330 PMID:27966929 More...
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Cyp3a23-3a1
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1
increases expression
EXP
Ritonavir results in increased expression of CYP3A23-3A1 mRNA
CTD
PMID:17719200
NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030 Ensembl chr12:9,254,475...9,285,030
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Cyp3a9
cytochrome P450, family 3, subfamily a, polypeptide 9
decreases activity
ISO
Ritonavir results in decreased activity of CYP3A5 protein
CTD
PMID:15523003
NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
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Cyp4a3
cytochrome P450, family 4, subfamily a, polypeptide 3
decreases expression
EXP
Ritonavir results in decreased expression of CYP4A3 mRNA
CTD
PMID:17719200
NCBI chr 5:129,097,571...129,115,488
Ensembl chr 5:129,097,926...129,115,463
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Cyp4b1
cytochrome P450, family 4, subfamily b, polypeptide 1
affects expression decreases expression
EXP
Ritonavir affects the expression of CYP4B1 mRNA Ritonavir results in decreased expression of CYP4B1 mRNA
CTD
PMID:17719200
NCBI chr 5:129,139,019...129,176,860
Ensembl chr 5:129,139,038...129,156,348
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Cyp51
cytochrome P450, family 51
increases expression
EXP
Ritonavir results in increased expression of CYP51 mRNA
CTD
PMID:17719200
NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410
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Cyp7a1
cytochrome P450 family 7 subfamily A member 1
decreases expression
ISO EXP
Ritonavir results in decreased expression of CYP7A1 mRNA
CTD
PMID:17719200 PMID:26626330
NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
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Cyp8b1
cytochrome P450 family 8 subfamily B member 1
decreases expression
ISO EXP
Ritonavir results in decreased expression of CYP8B1 Ritonavir results in decreased expression of CYP8B1 mRNA
CTD
PMID:17719200 PMID:26626330
NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
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Dhcr7
7-dehydrocholesterol reductase
affects expression
EXP
Ritonavir affects the expression of DHCR7 mRNA
CTD
PMID:17719200
NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055
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E2f1
E2F transcription factor 1
decreases expression
ISO
Ritonavir results in decreased expression of E2F1 mRNA; Ritonavir results in decreased expression of E2F1 protein
CTD
PMID:19386116
NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361
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E2f2
E2F transcription factor 2
decreases expression
ISO
Ritonavir results in decreased expression of E2F2 mRNA
CTD
PMID:19386116
NCBI chr 5:148,399,193...148,422,595
Ensembl chr 5:148,399,642...148,421,217
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E2f3
E2F transcription factor 3
decreases expression
ISO
Ritonavir results in decreased expression of E2F3 mRNA
CTD
PMID:19386116
NCBI chr17:34,601,756...34,679,139
Ensembl chr17:34,601,830...34,676,253
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Ehhadh
enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase
affects expression
EXP
Ritonavir affects the expression of EHHADH mRNA
CTD
PMID:17719200
NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188
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Esr1
estrogen receptor 1
decreases expression
ISO
Ritonavir results in decreased expression of ESR1 protein
CTD
PMID:16551874
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Faslg
Fas ligand
decreases expression
ISO
Ritonavir results in decreased expression of FASLG protein
CTD
PMID:10551732
NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
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Fasn
fatty acid synthase
affects expression
EXP
Ritonavir affects the expression of FASN mRNA
CTD
PMID:17719200
NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
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Fgf19
fibroblast growth factor 19
increases expression
ISO
Ritonavir results in increased expression of FGF19 mRNA
CTD
PMID:26626330
NCBI chr 1:200,056,526...200,060,980
Ensembl chr 1:200,056,644...200,060,287
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
increases expression
ISO
Ritonavir results in increased expression of FOS protein
CTD
PMID:15504750
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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Glb1
galactosidase, beta 1
multiple interactions increases activity
ISO
Acetylcysteine inhibits the reaction [Ritonavir results in increased activity of GLB1 protein]; FTI 277 inhibits the reaction [Ritonavir results in increased activity of GLB1 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Ritonavir results in increased activity of GLB1 protein]; Pravastatin inhibits the reaction [Ritonavir results in increased activity of GLB1 protein]
CTD
PMID:20884875
NCBI chr 8:114,085,508...114,158,127
Ensembl chr 8:114,085,508...114,158,127
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Gpd1
glycerol-3-phosphate dehydrogenase 1
multiple interactions
ISO
Ritonavir promotes the reaction [[INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of GPD1 protein]
CTD
PMID:11101056
NCBI chr 7:130,842,526...130,851,530
Ensembl chr 7:130,844,138...130,851,529
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Hmox1
heme oxygenase 1
multiple interactions increases expression
ISO
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Ritonavir results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Ritonavir results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Ritonavir results in increased expression of HMOX1 protein]; Bilirubin inhibits the reaction [Ritonavir results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [Ritonavir results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [Ritonavir results in increased expression of HMOX1 protein]; HMOX1 protein inhibits the reaction [Ritonavir results in increased expression of ICAM1 protein]; NFE2L2 protein mutant form inhibits the reaction [Ritonavir results in increased expression of HMOX1 mRNA]; Ritonavir promotes the reaction [Atazanavir Sulfate results in increased expression of HMOX1 mRNA]; Ritonavir promotes the reaction [HMOX1 protein results in increased chemical synthesis of Bilirubin]; Ritonavir promotes the reaction [Lopinavir results in increased expression of HMOX1 mRNA]; Rotenone inhibits the reaction [Ritonavir results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [Ritonavir results in increased expression of HMOX1 protein]; tricarbonyldichlororuthenium (II) dimer promotes the reaction [Ritonavir results in increased expression of HMOX1 protein] Ritonavir results in increased expression of HMOX1 mRNA; Ritonavir results in increased expression of HMOX1 protein
CTD
PMID:15504750 PMID:26968795
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Hsp90aa1
heat shock protein 90 alpha family class A member 1
affects response to substance
ISO
HSP90AA1 protein affects the susceptibility to Ritonavir
CTD
PMID:16551874
NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
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Hsph1
heat shock protein family H (Hsp110) member 1
increases expression
ISO
Ritonavir results in increased expression of HSPH1 protein
CTD
PMID:26626330
NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224
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Icam1
intercellular adhesion molecule 1
increases expression multiple interactions
ISO
Ritonavir results in increased expression of ICAM1 protein HMOX1 protein inhibits the reaction [Ritonavir results in increased expression of ICAM1 protein]
CTD
PMID:26968795
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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Ifng
interferon gamma
multiple interactions
ISO
Ritonavir inhibits the reaction [IFNG protein results in increased secretion of TNF protein]
CTD
PMID:10551732
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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Il6
interleukin 6
multiple interactions increases expression increases secretion
ISO
diphenyleneiodonium inhibits the reaction [Ritonavir results in increased expression of IL6 protein]; Pravastatin inhibits the reaction [Ritonavir results in increased secretion of IL6 protein]; Ritonavir inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] Ritonavir results in increased expression of IL6 mRNA; Ritonavir results in increased expression of IL6 protein rosiglitazone inhibits the reaction [Ritonavir results in increased expression of IL6 mRNA]
CTD
PMID:15388451 PMID:15865214 PMID:17668557 PMID:20884875
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Il7
interleukin 7
decreases expression
ISO
Ritonavir results in decreased expression of IL7
CTD
PMID:26626330
NCBI chr 2:94,235,219...94,280,075
Ensembl chr 2:94,234,766...94,280,075
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Ins1
insulin 1
multiple interactions
ISO
Ritonavir inhibits the reaction [[INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] results in increased expression of CEBPA protein]; Ritonavir inhibits the reaction [[INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] results in increased expression of PPARG protein]; Ritonavir promotes the reaction [[INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of GPD1 protein]; Ritonavir promotes the reaction [[INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of SREBF1 protein]
CTD
PMID:11101056
NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
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Jun
Jun proto-oncogene, AP-1 transcription factor subunit
increases expression
ISO
Ritonavir results in increased expression of JUN protein
CTD
PMID:15504750
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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Lep
leptin
multiple interactions decreases expression
ISO
diphenyleneiodonium inhibits the reaction [Ritonavir results in decreased expression of LEP protein]
CTD
PMID:17668557
NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
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Lif
LIF, interleukin 6 family cytokine
decreases expression
ISO
Ritonavir results in decreased expression of LIF
CTD
PMID:26626330
NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482
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Lmna
lamin A/C
increases expression increases farnesylation
ISO
Ritonavir results in increased expression of LMNA protein Ritonavir results in increased farnesylation of LMNA protein alternative form
CTD
PMID:18230615 PMID:20884875
NCBI chr 2:173,939,751...173,960,423
Ensembl chr 2:173,939,751...173,960,423
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Lpl
lipoprotein lipase
affects expression
ISO
Ritonavir affects the expression of LPL mRNA
CTD
PMID:11741158
NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
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Myc
MYC proto-oncogene, bHLH transcription factor
decreases expression
ISO
Ritonavir results in decreased expression of MYC mRNA
CTD
PMID:16174765
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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Nfe2l2
NFE2 like bZIP transcription factor 2
increases expression multiple interactions
ISO
Ritonavir results in increased expression of NFE2L2 protein NFE2L2 protein mutant form inhibits the reaction [Ritonavir results in increased expression of HMOX1 mRNA]
CTD
PMID:26968795
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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Nfkb1
nuclear factor kappa B subunit 1
decreases activity
ISO
Ritonavir results in decreased activity of NFKB1 protein
CTD
PMID:16174765
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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Nfkbia
NFKB inhibitor alpha
decreases phosphorylation
ISO
Ritonavir results in decreased phosphorylation of NFKBIA protein
CTD
PMID:16174765
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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Nlrc5
NLR family, CARD domain containing 5
decreases expression
ISO
Ritonavir results in decreased expression of NLRC5
CTD
PMID:26626330
NCBI chr19:10,477,638...10,581,023
Ensembl chr19:10,477,628...10,562,121
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Nos3
nitric oxide synthase 3
multiple interactions decreases expression
ISO
Masoprocol inhibits the reaction [Ritonavir results in decreased expression of NOS3 mRNA]
CTD
PMID:22037733
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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Notch4
notch receptor 4
decreases expression multiple interactions
EXP
Ritonavir results in decreased expression of NOTCH4 protein [Saquinavir co-treated with Nicotine co-treated with Ritonavir] results in decreased expression of NOTCH4 protein; Vitamin E inhibits the reaction [[Nicotine co-treated with Ritonavir co-treated with Saquinavir] results in decreased expression of NOTCH4 protein]
CTD
PMID:20722969
NCBI chr20:4,160,362...4,184,466
Ensembl chr20:4,160,445...4,184,465
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Nr1h3
nuclear receptor subfamily 1, group H, member 3
increases expression
ISO
Ritonavir increases expression of NR1H3 mRNA in macrophages
RGD
PMID:18849545
RGD:401842387
NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722
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Nr1h4
nuclear receptor subfamily 1, group H, member 4
increases expression
ISO
Ritonavir results in increased expression of NR1H4 mRNA
CTD
PMID:26626330
NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
multiple interactions increases activity
ISO EXP
Ritonavir binds to and results in increased activity of NR1I2 protein Ritonavir results in increased activity of NR1I2 protein
CTD
PMID:14977870 PMID:15849716 PMID:27732639
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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Parp1
poly (ADP-ribose) polymerase 1
increases cleavage
ISO
Ritonavir results in increased cleavage of PARP1 protein
CTD
PMID:19386116 PMID:21270666
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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Pon1
paraoxonase 1
decreases activity
EXP
Ritonavir results in decreased activity of PON1 protein
CTD
PMID:27378623
NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
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Pparg
peroxisome proliferator-activated receptor gamma
multiple interactions increases expression
ISO
Ritonavir inhibits the reaction [[INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] results in increased expression of PPARG protein] Ritonavir results in increased expression of PPARG mRNA
CTD
PMID:11101056 PMID:17879945
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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Prkca
protein kinase C, alpha
multiple interactions increases expression increases activity
ISO
Ritonavir binds to and affects the localization of PRKCA protein Ritonavir results in increased expression of PRKCA protein Ritonavir results in increased activity of PRKCA protein
CTD
PMID:22020176
NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
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Psma1
proteasome 20S subunit alpha 1
affects expression
EXP
Ritonavir affects the expression of PSMA1 mRNA
CTD
PMID:17719200
NCBI chr 1:168,442,421...168,453,440
Ensembl chr 1:168,440,936...168,453,472
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Psmb3
proteasome 20S subunit beta 3
affects expression
EXP
Ritonavir affects the expression of PSMB3 mRNA
CTD
PMID:17719200
NCBI chr10:82,697,425...82,704,521
Ensembl chr10:82,697,425...82,704,521
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Psmb5
proteasome 20S subunit beta 5
increases expression
EXP
Ritonavir results in increased expression of PSMB5 mRNA
CTD
PMID:20213465
NCBI chr15:28,072,772...28,077,367
Ensembl chr15:28,072,781...28,077,440
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Rb1
RB transcriptional corepressor 1
decreases phosphorylation increases expression
ISO
Ritonavir results in decreased phosphorylation of RB1 protein Ritonavir results in increased expression of RB1 mRNA
CTD
PMID:16551874 PMID:19386116 PMID:21270666
NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
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Rbl1
RB transcriptional corepressor like 1
increases expression
ISO
Ritonavir results in increased expression of RBL1 mRNA
CTD
PMID:19386116
NCBI chr 3:145,806,160...145,869,434
Ensembl chr 3:145,807,095...145,869,330
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Rbl2
RB transcriptional corepressor like 2
decreases expression
ISO
Ritonavir results in decreased expression of RBL2 mRNA
CTD
PMID:19386116
NCBI chr19:15,876,852...15,923,632
Ensembl chr19:15,876,853...15,923,572
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Rel
REL proto-oncogene, NF-kB subunit
decreases activity
ISO
Ritonavir results in decreased activity of REL protein
CTD
PMID:16174765
NCBI chr14:97,690,105...97,721,194
Ensembl chr14:97,695,161...97,720,892
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Rela
RELA proto-oncogene, NF-kB subunit
decreases activity
ISO
Ritonavir results in decreased activity of RELA protein
CTD
PMID:16174765
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Scarb1
scavenger receptor class B, member 1
multiple interactions increases expression
ISO
Estradiol inhibits the reaction [Ritonavir results in increased expression of SCARB1 protein] Ritonavir results in increased expression of SCARB1 mRNA
CTD
PMID:17879945
NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647
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Scp2
sterol carrier protein 2
decreases expression
ISO
Ritonavir results in decreased expression of SCP2
CTD
PMID:26626330
NCBI chr 5:122,806,949...122,881,259
Ensembl chr 5:122,776,549...122,881,287
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Slc10a1
solute carrier family 10 member 1
decreases expression
ISO
Ritonavir results in decreased expression of SLC10A1
CTD
PMID:26626330
NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
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Slc51a
solute carrier family 51 member A
decreases expression
ISO
Ritonavir results in decreased expression of SLC51A
CTD
PMID:26626330
NCBI chr11:68,299,086...68,313,485
Ensembl chr11:68,299,086...68,313,485
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Slco4c1
solute carrier organic anion transporter family, member 4C1
multiple interactions
ISO
Ritonavir inhibits the reaction [SLCO4C1 protein affects the transport of traumatic acid]
CTD
PMID:39041788
NCBI chr 9:97,177,497...97,229,161
Ensembl chr 9:97,178,861...97,229,715
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Src
SRC proto-oncogene, non-receptor tyrosine kinase
decreases phosphorylation
ISO
Ritonavir results in decreased phosphorylation of SRC protein
CTD
PMID:21270666
NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
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Srebf1
sterol regulatory element binding transcription factor 1
multiple interactions
ISO
Ritonavir promotes the reaction [[INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of SREBF1 protein]
CTD
PMID:11101056
NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
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Stat3
signal transducer and activator of transcription 3
decreases phosphorylation
ISO
Ritonavir results in decreased phosphorylation of STAT3 protein
CTD
PMID:21270666
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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Tjp1
tight junction protein 1
decreases expression multiple interactions
EXP
Ritonavir results in decreased expression of TJP1 protein [Saquinavir co-treated with Nicotine co-treated with Ritonavir] results in decreased expression of TJP1 protein; Vitamin E inhibits the reaction [[Nicotine co-treated with Ritonavir co-treated with Saquinavir] results in decreased expression of TJP1 protein]
CTD
PMID:20722969
NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
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Tnf
tumor necrosis factor
decreases secretion increases expression multiple interactions
ISO
Ritonavir results in decreased secretion of TNF protein Ritonavir results in increased expression of TNF mRNA; Ritonavir results in increased expression of TNF protein Ritonavir inhibits the reaction [IFNG protein results in increased secretion of TNF protein]; Ritonavir inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] rosiglitazone inhibits the reaction [Ritonavir results in increased expression of TNF mRNA]
CTD
PMID:10551732 PMID:15388451 PMID:15865214
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tp53
tumor protein p53
multiple interactions increases expression
ISO
FTI 277 inhibits the reaction [Ritonavir results in increased expression of TP53 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Ritonavir results in increased expression of TP53 protein]; Pravastatin inhibits the reaction [Ritonavir results in increased expression of TP53 protein]
CTD
PMID:19386116 PMID:20884875
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Ugt1a1
UDP glucuronosyltransferase family 1 member A1
affects expression
ISO
Ritonavir affects the expression of UGT1A1 mRNA
CTD
PMID:15849716
NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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Zmpste24
zinc metallopeptidase STE24
decreases activity
ISO
Ritonavir results in decreased activity of ZMPSTE24 protein
CTD
PMID:18230615
NCBI chr 5:134,627,218...134,660,360
Ensembl chr 5:134,627,229...134,660,110
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