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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:(5Z)-5-(quinoxalin-6-ylmethylidene)-1,3-thiazolidine-2,4-dione
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Accession:CHEBI:45302 term browser browse the term
Definition:A quinoxaline derivative that is quinoxaline in which the hydrogen at position 6 is replaced by a (2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl group. It is a potent inhibitor of the PI3Kgamma, with an IC50 of 8 nM and inhibits the progression of joint inflammation and damage in both lymphocyte-independent and dependent mouse models of rheumatoid arthritis.
Synonyms:related_synonym: 5-(6-quinoxalinylmethylene)-2,4-thiazolidinedione;   5-[(quinoxalin-6-yl)methylidene]-1,3-thiazolidine-2,4-dione;   5-quinoxalin-6-ylmethylene-thiazolidine-2,4-dione;   5-quinoxalin-6-ylmethylenethiazolidine-2,4-dione;   AS-605240;   AS605240;   Formula=C12H7N3O2S;   InChI=1S/C12H7N3O2S/c16-11-10(18-12(17)15-11)6-7-1-2-8-9(5-7)14-4-3-13-8/h1-6H,(H,15,16,17)/b10-6-;   InChIKey=SQWZFLMPDUSYGV-POHAHGRESA-N;   SMILES=O=C1NC(=O)\\C(S1)=C\\C1=CC2=C(C=C1)N=CC=N2
 xref: CAS:648450-29-7;   DrugBank:DB04769;   LINCS:LSM-42785;   PDBeChem:QYT;   PMID:16127437;   PMID:19950590;   PMID:20189103;   PMID:20510675;   PMID:20651289;   PMID:20881611;   PMID:21866628;   PMID:22403300;   PMID:29799846;   PMID:30571560;   PMID:31195053;   PMID:32038117;   PMID:32882317;   Patent:CN101550135


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  CHEBI ontology 19874
    role 19844
      application 19689
        anti-inflammatory agent 16666
          (5Z)-5-(quinoxalin-6-ylmethylidene)-1,3-thiazolidine-2,4-dione 0
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Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      carbon group element atom 19751
                        carbon atom 19748
                          organic molecular entity 19748
                            organic molecule 19700
                              organic cyclic compound 19490
                                organic heterocyclic compound 18868
                                  organic heteropolycyclic compound 18294
                                    organic heterobicyclic compound 17237
                                      mancude organic heterobicyclic parent 8321
                                        naphthyridine 2252
                                          quinoxaline 398
                                            quinoxaline derivative 398
                                              (5Z)-5-(quinoxalin-6-ylmethylidene)-1,3-thiazolidine-2,4-dione 0
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