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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:dienestrol
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Accession:CHEBI:4518 term browser browse the term
Definition:An olefinic compound that is hexa-2,4-diene substituted by 4-hydroxyphenyl groups at positions 3 and 4 respectively.
Synonyms:exact_synonym: 4,4'-hexa-2,4-diene-3,4-diyldiphenol
 related_synonym: 4,4'-Hydroxy-gamma,delta-diphenyl-beta,delta-hexadiene;   Dehydrostilbestrol;   Di(p-oxyphenyl)-2,4-hexadiene;   Formula=C18H18O2;   InChI=1S/C18H18O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h3-12,19-20H,1-2H3;   InChIKey=NFDFQCUYFHCNBW-UHFFFAOYSA-N;   SMILES=CC=C(c1ccc(O)cc1)C(=CC)c1ccc(O)cc1;   p,p'-(Diethylideneethylene)diphenol
 xref: CAS:84-17-3;   DrugBank:DB00890;   KEGG:C08090;   KEGG:D00898;   LINCS:LSM-4142
 xref_mesh: MESH:D004028
 xref: PMID:18275104;   PMID:25188907;   Patent:US2464203;   Patent:US2465505;   Reaxys:2053692;   Wikipedia:Dienestrol


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dienestrol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afp alpha-fetoprotein affects binding EXP Dienestrol binds to AFP protein CTD PMID:23013281 PMID:25349334 NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 multiple interactions EXP [Dienestrol co-treated with Flutamide] results in increased expression of CYP17A1 mRNA CTD PMID:32738380 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
affects binding
decreases activity		 ISO Dienestrol binds to and results in increased activity of ESR1 protein; Dienestrol inhibits the reaction [16 alpha-iodoestradiol binds to ESR1 protein]; Dienestrol promotes the reaction [ESR1 protein alternative form binds to ESR1 protein alternative form]
Dienestrol binds to ESR1 protein
Dienestrol results in decreased activity of ESR1 protein		 CTD PMID:9048584 PMID:15026083 PMID:18976723 PMID:19233257 PMID:25012808 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
affects binding		 EXP Dienestrol inhibits the reaction [16 alpha-iodoestradiol binds to ESR2 protein]
Dienestrol binds to Esr2 protein		 CTD
RGD		 PMID:9048584 PMID:9048584 RGD:8694130 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Dienestrol inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO Dienestrol results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Shbg sex hormone binding globulin affects binding ISO Dienestrol binds to SHBG protein CTD PMID:25349334 NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057 		JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 decreases activity ISO Dienestrol results in decreased activity of SULT1E1 protein CTD PMID:16914110 NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275 		JBrowse link
G Tp53 tumor protein p53 affects activity ISO Dienestrol affects the activity of TP53 protein CTD PMID:35435491 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19922
    chemical entity 19920
      atom 19892
        nonmetal atom 19849
          carbon atom 19802
            organic molecular entity 19775
              olefinic compound 16967
                dienestrol 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19922
    subatomic particle 19892
      composite particle 19892
        hadron 19920
          baryon 19892
            nucleon 19920
              atomic nucleus 19892
                atom 19892
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19805
                        carbon atom 19802
                          organic molecular entity 19775
                            organic molecule 19755
                              organic cyclic compound 19545
                                organic aromatic compound 19380
                                  phenols 18688
                                    dienestrol 9
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