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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:dicloxacillin
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Accession:CHEBI:4511 term browser browse the term
Definition:A penicillin that is 6-aminopenicillanic acid in which one of the amino hydrogens is replaced by a 3-(2,6-dichlorophenyl)-5-methyl-1,2-oxazol-4-yl]formyl group.
Synonyms:exact_synonym: 6beta-{[3-(2,6-dichlorophenyl)-5-methyl-1,2-oxazol-4-yl]carboxamido}-2,2-dimethylpenam-3alpha-carboxylic acid
 related_synonym: (2S,5R,6R)-6-({[3-(2,6-dichlorophenyl)-5-methyl-1,2-oxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid;   Formula=C19H17Cl2N3O5S;   InChI=1S/C19H17Cl2N3O5S/c1-7-10(12(23-29-7)11-8(20)5-4-6-9(11)21)15(25)22-13-16(26)24-14(18(27)28)19(2,3)30-17(13)24/h4-6,13-14,17H,1-3H3,(H,22,25)(H,27,28)/t13-,14+,17-/m1/s1;   InChIKey=YFAGHNZHGGCZAX-JKIFEVAISA-N;   SMILES=[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)c1c(C)onc1-c1c(Cl)cccc1Cl)C(O)=O;   dicloxacilina;   dicloxacilline;   dicloxacillinum
 xref: CAS:3116-76-5;   DrugBank:DB00485;   Drug_Central:866;   KEGG:C06950;   KEGG:D02348;   LINCS:LSM-5234
 xref_mesh: MESH:D004009
 xref: PMID:26962156;   PMID:28721014;   PMID:29017833;   PMID:29105855;   PMID:29253094;   PMID:29504695;   Patent:GB978299;   Patent:US3239507;   Reaxys:1233662;   Wikipedia:Dicloxacillin
 cyclic_relationship: is_conjugate_acid_of CHEBI:52017


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dicloxacillin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO Dicloxacillin results in decreased activity of ABCB11 protein CTD PMID:20829430 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions
increases expression		 ISO AGER protein affects the reaction [Dicloxacillin results in increased expression of GPT protein]
Dicloxacillin results in increased expression of AGER mRNA		 CTD PMID:24747151 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions
increases expression		 ISO [Progesterone co-treated with Dicloxacillin] results in increased expression of CXCL2 mRNA
Dicloxacillin results in increased expression of CXCL2 mRNA		 CTD PMID:22157104 PMID:24747151 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression
multiple interactions		 ISO Dicloxacillin results in increased expression of CXCL1 mRNA
Progesterone promotes the reaction [Dicloxacillin results in increased expression of CXCL1 mRNA]		 CTD PMID:22157104 NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases expression		 ISO Dicloxacillin results in increased expression of and results in increased activity of CYP3A4 protein
Dicloxacillin results in increased expression of CYP3A4 mRNA		 CTD PMID:18505790 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
increases expression		 ISO AGER protein affects the reaction [Dicloxacillin results in increased expression of GPT protein]; eritoran inhibits the reaction [Dicloxacillin results in increased expression of GPT protein] CTD PMID:24747151 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Hmgb1 high mobility group box 1 increases expression ISO Dicloxacillin results in increased expression of HMGB1 protein CTD PMID:24747151 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression ISO Dicloxacillin results in increased expression of ICAM1 protein CTD PMID:14729754 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Il1b interleukin 1 beta increases expression ISO Dicloxacillin results in increased expression of IL1B mRNA CTD PMID:24747151 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il4 interleukin 4 increases response to substance
increases expression		 ISO IL4 results in increased susceptibility to Dicloxacillin
Dicloxacillin results in increased expression of IL4 protein		 CTD PMID:21094227 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 increases expression ISO Dicloxacillin results in increased expression of NLRP3 mRNA CTD PMID:24747151 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Dicloxacillin results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G S100a8 S100 calcium binding protein A8 increases expression ISO Dicloxacillin results in increased expression of S100A8 mRNA CTD PMID:24747151 PMID:28138970 NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643 		JBrowse link
G S100a9 S100 calcium binding protein A9 increases expression ISO Dicloxacillin results in increased expression of S100A9 mRNA CTD PMID:24747151 NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      biological role 19842
        aetiopathogenetic role 19217
          allergen 17667
            penicillin 314
              dicloxacillin 14
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      carbon group element atom 19751
                        carbon atom 19748
                          organic molecular entity 19748
                            heteroorganic entity 19505
                              organochalcogen compound 19268
                                organooxygen compound 19184
                                  carbon oxoacid 18654
                                    carboxylic acid 18651
                                      carboacyl group 17694
                                        univalent carboacyl group 17694
                                          carbamoyl group 17545
                                            carboxamide 17545
                                              lactam 8389
                                                beta-lactam 828
                                                  beta-lactam antibiotic 813
                                                    penams 314
                                                      penicillanic acids 314
                                                        penicillanic acid 314
                                                          6-aminopenicillanic acid 314
                                                            penicillin 314
                                                              dicloxacillin 14
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