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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:propofol
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Accession:CHEBI:44915 term browser browse the term
Definition:A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
Synonyms:exact_synonym: 2,6-bis(propan-2-yl)phenol
 related_synonym: 2,6-BIS(1-METHYLETHYL)PHENOL;   2,6-Diisopropylphenol;   Diprivan;   Disoprivan;   Disoprofol;   Formula=C12H18O;   InChI=1S/C12H18O/c1-8(2)10-6-5-7-11(9(3)4)12(10)13/h5-9,13H,1-4H3;   InChIKey=OLBCVFGFOZPWHH-UHFFFAOYSA-N;   Rapinovet;   SMILES=CC(C)c1cccc(C(C)C)c1O;   propofolum
 alt_id: CHEBI:44914;   CHEBI:8495
 xref: Beilstein:1866484;   CAS:2078-54-8;   DrugBank:DB00818;   Drug_Central:2302;   KEGG:C07523;   KEGG:D00549;   LINCS:LSM-3847
 xref_mesh: MESH:D015742
 xref: PDBeChem:PFL;   VSDB:1846;   Wikipedia:Propofol


show annotations for term's descendants           Sort by:
propofol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abhd11-as1 ABHD11 antisense RNA 1 (tail to tail) increases expression ISO Propofol results in increased expression of BICDL3P mRNA CTD PMID:35238236 NCBI chr12:21,681,118...21,682,106 JBrowse link
G Acta1 actin, alpha 1, skeletal muscle multiple interactions EXP HMOX1 protein affects the reaction [Propofol inhibits the reaction [Glucose results in increased expression of ACTA1 mRNA]]; Propofol inhibits the reaction [Glucose results in increased expression of ACTA1 mRNA]; STAT3 protein affects the reaction [Propofol inhibits the reaction [Glucose results in increased expression of ACTA1 mRNA]] CTD PMID:24810525 NCBI chr19:51,883,709...51,886,735
Ensembl chr19:51,883,715...51,886,742 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
decreases phosphorylation		 EXP
ISO		 Propofol promotes the reaction [Streptozocin results in decreased phosphorylation of AKT1 protein]
Propofol results in increased phosphorylation of AKT1 protein
Propofol results in decreased phosphorylation of AKT1 protein
CASC9 protein inhibits the reaction [Propofol results in decreased phosphorylation of AKT1 protein]		 CTD PMID:24810525 PMID:35238236 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 decreases expression
multiple interactions		 EXP Propofol results in decreased expression of APAF1 protein
Propofol inhibits the reaction [Doxorubicin results in increased expression of APAF1 protein]		 CTD PMID:21468576 PMID:22015447 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540 		JBrowse link
G Arc activity-regulated cytoskeleton-associated protein multiple interactions
decreases expression		 EXP Bicuculline inhibits the reaction [Propofol results in decreased expression of ARC protein] CTD PMID:18946287 NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378 		JBrowse link
G Avp arginine vasopressin multiple interactions ISO [Propofol co-treated with desflurane] results in increased expression of AVP protein CTD PMID:8017643 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
decreases expression		 EXP
ISO		 [Resveratrol co-treated with Propofol] results in decreased expression of BAX; NUFIP1 protein affects the reaction [Propofol results in increased expression of BAX protein]; PEA15 protein inhibits the reaction [Propofol results in increased expression of BAX protein]; Propofol inhibits the reaction [Doxorubicin results in increased expression of BAX protein]
Propofol results in decreased expression of BAX
[NUFIP1 affects the susceptibility to Propofol] which affects the expression of BAX protein; Acetylcysteine inhibits the reaction [Propofol results in increased expression of BAX protein]		 CTD PMID:21786383 PMID:22015447 PMID:23353162 PMID:28804952 PMID:31257496 More... NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
multiple interactions
decreases expression		 EXP
ISO		 Propofol results in increased expression of BCL2; Propofol results in increased expression of BCL2 mRNA; Propofol results in increased expression of BCL2 protein
[Resveratrol co-treated with Propofol] results in increased expression of BCL2; NUFIP1 protein affects the reaction [Propofol results in decreased expression of BCL2 protein]; PEA15 protein inhibits the reaction [Propofol results in decreased expression of BCL2 protein]; Propofol inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; Propofol inhibits the reaction [Streptozocin results in decreased expression of BCL2 protein]; Wortmannin inhibits the reaction [Propofol results in increased expression of BCL2 protein]
[NUFIP1 affects the susceptibility to Propofol] which affects the expression of BCL2 protein; Acetylcysteine inhibits the reaction [Propofol results in decreased expression of BCL2 protein]		 CTD PMID:19703415 PMID:21786383 PMID:22015447 PMID:23353162 PMID:24810525 More... NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression EXP Propofol results in decreased expression of BCL2L1 mRNA; Propofol results in decreased expression of BCL2L1 protein CTD PMID:26254736 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479 		JBrowse link
G Blacat1 BLACAT1 overlapping LEMD1 locus increases expression ISO Propofol results in increased expression of BLACAT1 mRNA CTD PMID:35238236
G Bnip3 BCL2 interacting protein 3 multiple interactions ISO Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of BNIP3 mRNA]; Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of BNIP3 protein] CTD PMID:21307008 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359 		JBrowse link
G C17h10orf67 similar to human chromosome 10 open reading frame 67 increases expression ISO Propofol results in increased expression of C10ORF67 mRNA CTD PMID:35238236 NCBI chr17:82,062,461...82,174,401
Ensembl chr17:82,071,838...82,174,353 		JBrowse link
G C1h10orf143 similar to human chromosome 10 open reading frame 143 decreases expression ISO Propofol results in decreased expression of C10ORF143 mRNA CTD PMID:35238236 NCBI chr 1:192,184,440...192,222,676
Ensembl chr 1:192,184,445...192,222,398 		JBrowse link
G C3 complement C3 multiple interactions ISO [Triglycerides co-treated with Propofol] results in increased expression of C3 protein modified form CTD PMID:15983144 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429 		JBrowse link
G Cacna1i calcium voltage-gated channel subunit alpha1 I affects response to substance EXP CACNA1I protein affects the susceptibility to Propofol CTD PMID:15644869 NCBI chr 7:111,835,996...111,947,418
Ensembl chr 7:111,836,012...111,944,688 		JBrowse link
G Car1 carbonic anhydrase 1 decreases activity ISO Propofol analog results in decreased activity of CA1 protein; Propofol results in decreased activity of CA1 protein CTD PMID:19231207 NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208 		JBrowse link
G Car2 carbonic anhydrase 2 decreases activity ISO Propofol analog results in decreased activity of CA2 protein; Propofol results in decreased activity of CA2 protein CTD PMID:19231207 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818 		JBrowse link
G Car5a carbonic anhydrase 5A decreases expression ISO Propofol results in decreased expression of CA5A mRNA CTD PMID:35238236 NCBI chr19:49,973,092...50,002,948
Ensembl chr19:49,973,107...50,002,906 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
decreases expression
increases expression
increases cleavage		 EXP
ISO		 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole promotes the reaction [Propofol results in increased cleavage of CASP3 protein]; [Resveratrol co-treated with Propofol] results in decreased expression of CASP3; calpeptin inhibits the reaction [Propofol results in increased cleavage of CASP3 protein]; HMOX1 protein affects the reaction [Propofol inhibits the reaction [Glucose results in increased cleavage of CASP3 protein]]; hyperforin inhibits the reaction [Propofol results in increased cleavage of CASP3 protein]; NUFIP1 protein inhibits the reaction [Propofol results in increased cleavage of CASP3 protein]; PEA15 protein inhibits the reaction [Propofol results in decreased expression of CASP3 protein]; PEA15 protein inhibits the reaction [Propofol results in increased cleavage of CASP3 protein]; Propofol inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; Propofol inhibits the reaction [Glucose results in increased cleavage of CASP3 protein]; Propofol inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]; Propofol inhibits the reaction [Streptozocin results in increased cleavage of CASP3 protein]; STAT3 protein affects the reaction [Propofol inhibits the reaction [Glucose results in increased cleavage of CASP3 protein]]
Propofol results in increased activity of CASP3 protein
Propofol results in decreased expression of CASP3; Propofol results in decreased expression of CASP3 protein
Propofol results in increased expression of CASP3 protein modified form
Acetylcysteine inhibits the reaction [Propofol results in increased cleavage of CASP3 protein]		 CTD PMID:17640472 PMID:21786383 PMID:22015447 PMID:23353162 PMID:24810525 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 decreases cleavage
increases activity
increases cleavage
multiple interactions		 EXP
ISO		 Propofol results in decreased cleavage of CASP9 protein
Propofol results in increased activity of CASP9 protein
Propofol results in increased cleavage of CASP9 protein
Acetylcysteine inhibits the reaction [Propofol results in increased cleavage of CASP9 protein]		 CTD PMID:21468576 PMID:21786383 PMID:28804952 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase increases expression
multiple interactions
decreases activity		 ISO
EXP		 Propofol results in increased expression of CAT protein
Acetylcysteine inhibits the reaction [Propofol results in decreased activity of CAT protein]		 CTD PMID:16938161 PMID:21468576 PMID:28804952 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccdc196 coiled-coil domain containing 196 affects expression ISO Propofol affects the expression of CCDC196 mRNA CTD PMID:35238236 NCBI chr 6:96,913,960...96,939,415
Ensembl chr 6:96,915,869...96,931,141 		JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO Propofol results in decreased expression of CCNB1 protein CTD PMID:28804952 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccnd1 cyclin D1 increases expression ISO Propofol results in increased expression of CCND1 protein CTD PMID:28804952 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cd68 Cd68 molecule increases expression
multiple interactions		 ISO Propofol results in increased expression of CD68 mRNA
Lipopolysaccharides inhibits the reaction [Propofol results in increased expression of CD68 mRNA]		 CTD PMID:35953652 NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697 		JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO Propofol affects the reaction [LINC01133 affects the expression of CDH1 protein] CTD PMID:38146619 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdh11 cadherin 11 multiple interactions ISO Propofol inhibits the reaction [Lipopolysaccharides results in decreased expression of CDH11 mRNA] CTD PMID:35953652 NCBI chr19:2,148,447...2,305,754
Ensembl chr19:2,148,458...2,304,272 		JBrowse link
G Cdh2 cadherin 2 multiple interactions ISO Propofol affects the reaction [LINC01133 affects the expression of CDH2 protein] CTD PMID:38146619 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression
multiple interactions		 ISO Propofol results in decreased expression of CDK1 protein
[Propofol results in increased susceptibility to STA 9090] which results in decreased expression of CDK1 protein		 CTD PMID:24784839 PMID:28804952 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 multiple interactions
increases expression		 EXP Dexmedetomidine inhibits the reaction [Propofol results in increased expression of CDK5R1 protein] CTD PMID:31187143 NCBI chr10:65,484,266...65,485,467
Ensembl chr10:65,483,941...65,488,456 		JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 multiple interactions EXP Propofol inhibits the reaction [Acetylcholine results in increased activity of CHRM1 protein]; Propofol inhibits the reaction [Scopolamine Derivatives results in increased activity of CHRM1 protein] CTD PMID:14534362 NCBI chr 1:205,567,226...205,583,001
Ensembl chr 1:205,567,220...205,582,356 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 decreases phosphorylation
multiple interactions		 EXP Propofol results in decreased phosphorylation of CREB1 protein
PEA15 protein inhibits the reaction [Propofol results in decreased phosphorylation of CREB1 protein]		 CTD PMID:31257496 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 decreases expression ISO Propofol results in decreased expression of CXCL12 protein CTD PMID:36207479 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 mRNA] CTD PMID:21307008 NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 decreases expression ISO Propofol results in decreased expression of CXCR4 protein CTD PMID:36207479 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883 		JBrowse link
G Cycs cytochrome c, somatic increases expression ISO Propofol results in increased expression of CYCS protein CTD PMID:21786383 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases metabolic processing ISO CYP2B6 protein results in increased metabolism of Propofol CTD PMID:15769884 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Dio3os DIO3 opposite strand upstream RNA decreases expression ISO Propofol results in decreased expression of DIO3OS mRNA CTD PMID:35238236
G Dlg4 discs large MAGUK scaffold protein 4 increases expression
multiple interactions		 EXP Propofol results in increased expression of DLG4 protein
NUFIP1 protein affects the reaction [Propofol results in increased expression of DLG4 protein]		 CTD PMID:38599287 NCBI chr10:54,740,700...54,769,097
Ensembl chr10:54,739,470...54,767,153 		JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 increases phosphorylation
multiple interactions		 EXP Propofol results in increased phosphorylation of DPYSL2 protein
Dexmedetomidine inhibits the reaction [Propofol results in increased phosphorylation of DPYSL2 protein]		 CTD PMID:31187143 NCBI chr15:41,005,551...41,111,724
Ensembl chr15:41,005,551...41,111,829 		JBrowse link
G Edn1 endothelin 1 decreases expression
multiple interactions		 EXP
ISO		 Propofol results in decreased expression of EDN1 protein
Propofol inhibits the reaction [EDN1 protein affects the transport of Calcium]		 CTD PMID:9138053 PMID:17470888 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO [Propofol results in increased susceptibility to STA 9090] which results in decreased expression of EGFR protein CTD PMID:24784839 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Ephb2 Eph receptor B2 increases expression ISO Propofol results in increased expression of EPHB2 mRNA CTD PMID:35953652 NCBI chr 5:148,889,574...149,077,027
Ensembl chr 5:148,897,246...149,077,059 		JBrowse link
G Ewsr1 EWS RNA-binding protein 1 increases expression ISO Propofol results in increased expression of EWSR1 mRNA CTD PMID:35953652 NCBI chr14:79,965,365...79,994,108
Ensembl chr14:79,965,368...79,994,544 		JBrowse link
G Fam95c family with sequence similarity 95 member C decreases expression ISO Propofol results in decreased expression of FAM95C mRNA CTD PMID:35238236 NCBI chr17:54,681,040...54,721,106
Ensembl chr17:54,681,044...54,720,740 		JBrowse link
G Fas Fas cell surface death receptor increases expression ISO Propofol results in increased expression of FAS protein CTD PMID:21786383 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Fendrr FOXF1 adjacent non-coding developmental regulatory RNA decreases expression ISO Propofol results in decreased expression of FENDRR mRNA CTD PMID:35238236 NCBI chr19:49,127,225...49,152,780
Ensembl chr19:49,121,214...49,153,240 		JBrowse link
G Fn1 fibronectin 1 increases expression ISO Propofol results in increased expression of FN1 mRNA CTD PMID:35953652 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression		 EXP Lidocaine inhibits the reaction [Propofol results in increased expression of FOS protein]
Propofol results in increased expression of FOS mRNA; Propofol results in increased expression of FOS protein		 CTD PMID:10781476 PMID:17136530 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Foxo1 forkhead box O1 multiple interactions
increases expression		 ISO FOXO1 protein affects the reaction [Propofol results in increased expression of LINC01133 mRNA]
Propofol results in increased expression of FOXO1 mRNA; Propofol results in increased expression of FOXO1 protein		 CTD PMID:38146619 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790 		JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions ISO
EXP		 [Propofol co-treated with Pentobarbital] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; delta-hexachlorocyclohexane inhibits the reaction [Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Propofol affects the reaction [Flunitrazepam binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Propofol affects the reaction [Muscimol binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRE]]; Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRG2]]; Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Propofol results in increased activity of [GABRA1 protein binds to GABRB1 binds to GABRG2 protein alternative form]; Propofol results in increased activity of [GABRA1 protein binds to GABRB2 binds to GABRG2 protein alternative form]; Propofol results in increased activity of [GABRA1 protein binds to GABRB3 binds to GABRG2 protein alternative form]
Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Propofol results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]; Propofol results in increased activity of [GABRG2 binds to GABRA1 binds to GABRB2]		 CTD PMID:9316872 PMID:10049148 PMID:11399263 PMID:12939268 PMID:22029276 More... NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864 		JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 multiple interactions ISO Propofol results in increased activity of [GABRA2 protein binds to GABRB2 binds to GABRG2 protein alternative form]; Propofol results in increased activity of [GABRA2 protein binds to GABRB3 binds to GABRG2 protein alternative form]; Propofol results in increased activity of [GABRA2 protein binds to GABRB3] CTD PMID:29038840 NCBI chr14:37,097,251...37,230,030
Ensembl chr14:37,097,279...37,228,944 		JBrowse link
G Gabra4 gamma-aminobutyric acid type A receptor subunit alpha 4 increases expression ISO Propofol results in increased expression of GABRA4 mRNA CTD PMID:16733821 NCBI chr14:36,590,782...36,667,724
Ensembl chr14:36,590,782...36,665,844 		JBrowse link
G Gabra6 gamma-aminobutyric acid type A receptor subunit alpha6 multiple interactions ISO Propofol results in increased activity of [GABRA6 protein binds to GABRB2 binds to GABRG2 protein alternative form]; Propofol results in increased activity of [GABRA6 protein binds to GABRB3 binds to GABRG2 protein alternative form] CTD PMID:29038840 NCBI chr10:26,810,411...26,825,768
Ensembl chr10:26,810,423...26,825,769 		JBrowse link
G Gabrb1 gamma-aminobutyric acid type A receptor subunit beta1 multiple interactions ISO Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRE]]; Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRG2]]; Propofol results in increased activity of [GABRA1 protein binds to GABRB1 binds to GABRG2 protein alternative form] CTD PMID:10049148 PMID:29038840 NCBI chr14:36,068,725...36,548,946
Ensembl chr14:36,080,393...36,548,948 		JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 affects response to substance
multiple interactions		 EXP
ISO		 GABRB2 protein affects the susceptibility to Propofol
Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Propofol results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]; Propofol results in increased activity of [GABRG2 binds to GABRA1 binds to GABRB2]
Propofol results in increased activity of [GABRA1 protein binds to GABRB2 binds to GABRG2 protein alternative form]; Propofol results in increased activity of [GABRA2 protein binds to GABRB2 binds to GABRG2 protein alternative form]; Propofol results in increased activity of [GABRA6 protein binds to GABRB2 binds to GABRG2 protein alternative form]		 CTD PMID:11399263 PMID:12939268 PMID:29038840 NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251 		JBrowse link
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta 3 multiple interactions ISO [Propofol co-treated with Pentobarbital] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; delta-hexachlorocyclohexane inhibits the reaction [Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Propofol affects the reaction [Flunitrazepam binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Propofol affects the reaction [Muscimol binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Propofol results in increased activity of [GABRA1 protein binds to GABRB3 binds to GABRG2 protein alternative form]; Propofol results in increased activity of [GABRA2 protein binds to GABRB3 binds to GABRG2 protein alternative form]; Propofol results in increased activity of [GABRA2 protein binds to GABRB3]; Propofol results in increased activity of [GABRA6 protein binds to GABRB3 binds to GABRG2 protein alternative form] CTD PMID:9316872 PMID:22029276 PMID:29038840 NCBI chr 1:108,467,047...108,702,522
Ensembl chr 1:108,296,124...108,698,961 		JBrowse link
G Gabre gamma-aminobutyric acid type A receptor subunit epsilon multiple interactions
decreases response to substance		 ISO
EXP		 Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRE]]
GABRE protein results in decreased susceptibility to Propofol		 CTD PMID:9039914 PMID:10049148 NCBI chr  X:150,060,035...150,078,773
Ensembl chr  X:150,060,040...150,078,693 		JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions ISO
EXP		 [Propofol co-treated with Pentobarbital] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; delta-hexachlorocyclohexane inhibits the reaction [Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Propofol affects the reaction [Flunitrazepam binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Propofol affects the reaction [Muscimol binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRG2]]; Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Propofol results in increased activity of [GABRA1 protein binds to GABRB1 binds to GABRG2 protein alternative form]; Propofol results in increased activity of [GABRA1 protein binds to GABRB2 binds to GABRG2 protein alternative form]; Propofol results in increased activity of [GABRA1 protein binds to GABRB3 binds to GABRG2 protein alternative form]; Propofol results in increased activity of [GABRA2 protein binds to GABRB2 binds to GABRG2 protein alternative form]; Propofol results in increased activity of [GABRA2 protein binds to GABRB3 binds to GABRG2 protein alternative form]; Propofol results in increased activity of [GABRA6 protein binds to GABRB2 binds to GABRG2 protein alternative form]; Propofol results in increased activity of [GABRA6 protein binds to GABRB3 binds to GABRG2 protein alternative form]
Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Propofol results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]; Propofol results in increased activity of [GABRG2 binds to GABRA1 binds to GABRB2]		 CTD PMID:9316872 PMID:10049148 PMID:11399263 PMID:12939268 PMID:22029276 More... NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346 		JBrowse link
G Gas5 growth arrest specific 5 increases expression ISO Propofol results in increased expression of GAS5 mRNA CTD PMID:35238236 NCBI chr13:73,303,611...73,306,932 JBrowse link
G Gcnt4 glucosaminyl (N-acetyl) transferase 4 increases expression ISO Propofol results in increased expression of GCNT4 mRNA CTD PMID:35238236 NCBI chr 2:28,253,325...28,283,082
Ensembl chr 2:28,252,860...28,283,082 		JBrowse link
G Glud1 glutamate dehydrogenase 1 decreases expression ISO Propofol results in decreased expression of GLUD1 protein CTD PMID:36207479 NCBI chr16:9,640,312...9,673,961
Ensembl chr16:9,640,312...9,673,957 		JBrowse link
G Gnai2 G protein subunit alpha i2 decreases expression ISO Propofol results in decreased expression of GNAI2 mRNA CTD PMID:35238236 NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979 		JBrowse link
G Gnrh1 gonadotropin releasing hormone 1 increases expression
multiple interactions		 ISO Propofol results in increased expression of GNRH1 mRNA
Lipopolysaccharides promotes the reaction [Propofol results in increased expression of GNRH1 mRNA]		 CTD PMID:35953652 NCBI chr15:41,972,482...41,976,690
Ensembl chr15:41,972,905...41,973,581
Ensembl chr15:41,972,905...41,973,581 		JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 increases expression
multiple interactions		 EXP Propofol results in increased expression of GRIA2 protein
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid inhibits the reaction [Propofol results in increased expression of GRIA2 protein]		 CTD PMID:28663055 NCBI chr 2:165,949,379...166,069,510
Ensembl chr 2:165,947,521...166,069,510 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A affects response to substance ISO GRIN2A protein affects the susceptibility to Propofol CTD PMID:15731593 NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP Dexmedetomidine inhibits the reaction [Propofol results in decreased phosphorylation of and results in increased activity of GSK3B protein]; Propofol results in decreased phosphorylation of and results in increased activity of GSK3B protein CTD PMID:31187143 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G H19 H19 imprinted maternally expressed transcript decreases expression ISO Propofol results in decreased expression of H19 mRNA CTD PMID:35238236 NCBI chr 1:197,730,698...197,733,374
Ensembl chr 1:197,730,698...197,733,134 		JBrowse link
G Hgf hepatocyte growth factor multiple interactions ISO Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of HGF mRNA] CTD PMID:35953652 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
decreases expression		 ISO Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of HIF1A mRNA]; Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of HIF1A protein]
Propofol results in decreased expression of HIF1A protein		 CTD PMID:21307008 PMID:36207479 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions		 EXP Propofol results in increased expression of HMOX1 protein
HMOX1 protein affects the reaction [Propofol inhibits the reaction [Glucose results in decreased phosphorylation of STAT3 protein]]; HMOX1 protein affects the reaction [Propofol inhibits the reaction [Glucose results in increased cleavage of CASP3 protein]]; HMOX1 protein affects the reaction [Propofol inhibits the reaction [Glucose results in increased expression of ACTA1 mRNA]]; HMOX1 protein affects the reaction [Propofol inhibits the reaction [Glucose results in increased expression of NPPA mRNA]]; Propofol inhibits the reaction [Glucose results in decreased activity of HMOX1 protein]; Propofol inhibits the reaction [Streptozocin results in decreased activity of HMOX1 protein]; Propofol promotes the reaction [Glucose results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [Propofol inhibits the reaction [Glucose results in decreased activity of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [Propofol promotes the reaction [Glucose results in increased expression of HMOX1 protein]]		 CTD PMID:21468576 PMID:24810525 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hpse heparanase increases expression
multiple interactions		 ISO Propofol results in increased expression of HPSE mRNA
Lipopolysaccharides promotes the reaction [Propofol results in increased expression of HPSE mRNA]		 CTD PMID:35953652 NCBI chr14:8,896,593...8,937,011
Ensembl chr14:8,896,593...8,937,010 		JBrowse link
G Htatip2 HIV-1 Tat interactive protein 2 multiple interactions
increases expression		 ISO Lipopolysaccharides promotes the reaction [Propofol results in increased expression of HTATIP2 mRNA] CTD PMID:35953652 NCBI chr 1:99,473,411...99,488,632
Ensembl chr 1:99,469,245...99,488,629 		JBrowse link
G Igf1 insulin-like growth factor 1 increases expression ISO Propofol results in increased expression of IGF1 mRNA CTD PMID:35953652 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Igsf9b immunoglobulin superfamily, member 9B decreases expression ISO Propofol results in decreased expression of IGSF9B mRNA CTD PMID:35238236 NCBI chr 8:25,712,644...25,769,481
Ensembl chr 8:25,712,644...25,758,554 		JBrowse link
G Il10 interleukin 10 increases expression ISO Propofol results in increased expression of IL10 protein CTD PMID:17032661 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il18 interleukin 18 multiple interactions
increases expression		 ISO Lipopolysaccharides promotes the reaction [Propofol results in increased expression of IL18 mRNA] CTD PMID:35953652 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression		 ISO Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]
Propofol results in decreased expression of IL1B mRNA		 CTD PMID:35953652 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il2ra interleukin 2 receptor subunit alpha decreases secretion ISO Propofol results in decreased secretion of IL2RA protein CTD PMID:16119599 NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697 		JBrowse link
G Il6 interleukin 6 decreases expression
multiple interactions		 ISO Propofol results in decreased expression of IL6 protein
Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]		 CTD PMID:17032661 PMID:21307008 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Jak2 Janus kinase 2 decreases phosphorylation ISO Propofol decreases phosphorylation of JAK2 protein in colon epithelium RGD PMID:32386021 RGD:125097524 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression EXP Propofol results in increased expression of JUN mRNA CTD PMID:10781476 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Kng1 kininogen 1 multiple interactions ISO [Propofol co-treated with Pharmaceutical Vehicles] results in increased expression of KNG1 protein modified form; [Triglycerides co-treated with Propofol] results in increased expression of KNG1 protein modified form; Lidocaine inhibits the reaction [[Propofol co-treated with Pharmaceutical Vehicles] results in increased expression of KNG1 protein modified form]; nafamostat inhibits the reaction [[Propofol co-treated with Pharmaceutical Vehicles] results in increased expression of KNG1 protein modified form] CTD PMID:10655909 PMID:15983144 NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555 		JBrowse link
G Ldha lactate dehydrogenase A increases activity ISO Propofol increases activity of LDHA protein in colon epithelium RGD PMID:32386021 RGD:125097524 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472 		JBrowse link
G Lrcol1 leucine rich colipase-like 1 decreases expression ISO Propofol results in decreased expression of LRCOL1 mRNA CTD PMID:35238236 NCBI chr12:46,326,049...46,339,475
Ensembl chr12:46,326,077...46,337,953 		JBrowse link
G Lrg1 leucine-rich alpha-2-glycoprotein 1 increases expression ISO Propofol results in increased expression of LRG1 mRNA CTD PMID:21786383 NCBI chr 9:947,516...949,773
Ensembl chr 9:947,516...949,813 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 multiple interactions ISO Propofol inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAP2K1 protein] CTD PMID:19573522 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147 		JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 multiple interactions ISO Propofol inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAP2K2 protein] CTD PMID:19573522 NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation		 ISO
EXP		 Propofol inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAPK1 protein]
Propofol results in decreased phosphorylation of MAPK1 protein
PEA15 protein inhibits the reaction [Propofol results in decreased phosphorylation of MAPK1 protein]		 CTD PMID:19573522 PMID:31257496 PMID:36207479 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation		 ISO
EXP		 Propofol inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAPK3 protein]
Propofol results in decreased phosphorylation of MAPK3 protein
PEA15 protein inhibits the reaction [Propofol results in decreased phosphorylation of MAPK3 protein]		 CTD PMID:19573522 PMID:31257496 PMID:36207479 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase multiple interactions
increases expression		 ISO Lipopolysaccharides promotes the reaction [Propofol results in increased expression of MET mRNA] CTD PMID:35953652 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876 		JBrowse link
G Mgat5 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase multiple interactions
increases expression		 ISO Lipopolysaccharides promotes the reaction [Propofol results in increased expression of MGAT5 mRNA] CTD PMID:35953652 NCBI chr13:38,675,776...38,959,697
Ensembl chr13:38,676,119...38,959,513 		JBrowse link
G Mir1224 microRNA 1224 increases expression EXP Propofol results in increased expression of MIR1224 mRNA CTD PMID:26254736 NCBI chr11:80,306,902...80,306,986
Ensembl chr11:80,306,902...80,306,986 		JBrowse link
G Mir146a microRNA 146a decreases expression EXP Propofol results in decreased expression of MIR146A mRNA CTD PMID:26254736 NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610 		JBrowse link
G Mir146b microRNA 146b decreases expression EXP Propofol results in decreased expression of MIR146B mRNA CTD PMID:26254736 NCBI chr 1:245,203,438...245,203,525
Ensembl chr 1:245,203,438...245,203,525 		JBrowse link
G Mir155 microRNA 155 decreases expression EXP Propofol results in decreased expression of MIR155 mRNA CTD PMID:26254736 NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718 		JBrowse link
G Mir186 microRNA 186 multiple interactions ISO Propofol affects the reaction [LINC01133 affects the expression of MIR186 mRNA]; Propofol inhibits the reaction [MIR186 results in decreased expression of NR3C2 protein] CTD PMID:38146619 NCBI chr 2:246,582,806...246,582,891
Ensembl chr 2:246,582,806...246,582,891 		JBrowse link
G Mir221 microRNA 221 decreases expression EXP Propofol results in decreased expression of MIR221 mRNA CTD PMID:26254736 NCBI chr  X:3,429,465...3,429,573
Ensembl chr  X:3,429,465...3,429,573 		JBrowse link
G Mir222 microRNA 222 decreases expression EXP Propofol results in decreased expression of MIR222 mRNA CTD PMID:26254736 NCBI chr  X:3,428,904...3,429,006
Ensembl chr  X:3,428,904...3,429,006 		JBrowse link
G Mir27b microRNA 27b increases expression EXP Propofol results in increased expression of MIR27B mRNA CTD PMID:26254736 NCBI chr17:1,813,427...1,813,523
Ensembl chr17:1,813,426...1,813,529 		JBrowse link
G Mir3473 microRNA 3473 increases expression EXP Propofol results in increased expression of MIR3473 mRNA CTD PMID:26254736 NCBI chr13:39,499,246...39,499,312
Ensembl chr13:39,499,246...39,499,312 		JBrowse link
G Mir378 microRNA 378 increases expression EXP Propofol results in increased expression of MIR378 mRNA CTD PMID:26254736 NCBI chr18:54,858,559...54,858,623 JBrowse link
G Mir6215 microRNA 6215 increases expression EXP Propofol results in increased expression of MIR6215 mRNA CTD PMID:26254736 NCBI chr 5:151,850,759...151,850,825
Ensembl chr 5:151,850,759...151,850,825 		JBrowse link
G Mir665 microRNA 665 increases expression EXP Propofol results in increased expression of MIR665 mRNA CTD PMID:26254736 NCBI chr 6:128,539,440...128,539,533
Ensembl chr 6:128,539,440...128,539,533 		JBrowse link
G Mir99a microRNA 99a increases expression EXP Propofol results in increased expression of MIR99A mRNA CTD PMID:26254736 NCBI chr11:16,200,443...16,200,523
Ensembl chr11:16,200,443...16,200,523 		JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO Propofol results in decreased expression of MKI67 protein CTD PMID:36207479 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases expression		 ISO Lipopolysaccharides inhibits the reaction [Propofol results in decreased expression of MMP2 mRNA] CTD PMID:35953652 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp24os MMP24 opposite strand decreases expression ISO Propofol results in decreased expression of MMP24OS mRNA CTD PMID:35238236 NCBI chr 3:144,322,936...144,324,449 JBrowse link
G Mmp7 matrix metallopeptidase 7 multiple interactions
increases expression		 ISO Lipopolysaccharides promotes the reaction [Propofol results in increased expression of MMP7 mRNA] CTD PMID:35953652 NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902 		JBrowse link
G Mpc1 mitochondrial pyruvate carrier 1 decreases expression ISO Propofol results in decreased expression of MPC1 protein CTD PMID:36207479 NCBI chr 1:52,437,745...52,449,399
Ensembl chr 1:52,437,741...52,449,400 		JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation
multiple interactions		 ISO Propofol results in decreased phosphorylation of MTOR protein
CASC9 protein inhibits the reaction [Propofol results in decreased phosphorylation of MTOR protein]		 CTD PMID:35238236 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP Propofol inhibits the reaction [Halothane results in increased phosphorylation of NFKBIA protein] CTD PMID:16965849 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Ngf nerve growth factor multiple interactions EXP Bicuculline inhibits the reaction [Propofol inhibits the reaction [Vincristine results in decreased susceptibility to NGF protein]]; Propofol inhibits the reaction [Vincristine results in decreased susceptibility to NGF protein] CTD PMID:11991087 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP
ISO		 Propofol inhibits the reaction [Halothane results in increased expression of NOS2 protein]
Propofol inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 mRNA]; Propofol inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]		 CTD PMID:16965849 PMID:19573522 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nppa natriuretic peptide A multiple interactions EXP HMOX1 protein affects the reaction [Propofol inhibits the reaction [Glucose results in increased expression of NPPA mRNA]]; Propofol inhibits the reaction [Glucose results in increased expression of NPPA mRNA]; STAT3 protein affects the reaction [Propofol inhibits the reaction [Glucose results in increased expression of NPPA mRNA]] CTD PMID:24810525 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Npy neuropeptide Y multiple interactions EXP Propofol inhibits the reaction [Potassium results in increased secretion of NPY protein] CTD PMID:29320738 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495 		JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 multiple interactions ISO Propofol inhibits the reaction [MIR186 results in decreased expression of NR3C2 protein] CTD PMID:38146619 NCBI chr19:30,715,634...31,059,885
Ensembl chr19:30,715,648...31,059,885 		JBrowse link
G Nufip1 nuclear FMR1 interacting protein 1 multiple interactions
affects response to substance		 EXP
ISO		 NUFIP1 protein affects the reaction [Propofol results in decreased expression of BCL2 protein]; NUFIP1 protein affects the reaction [Propofol results in increased expression of BAX protein]; NUFIP1 protein affects the reaction [Propofol results in increased expression of DLG4 protein]; NUFIP1 protein inhibits the reaction [Propofol results in increased cleavage of CASP3 protein]
[NUFIP1 affects the susceptibility to Propofol] which affects the cleavage of CASP protein; [NUFIP1 affects the susceptibility to Propofol] which affects the expression of BAX protein; [NUFIP1 affects the susceptibility to Propofol] which affects the expression of BCL2 protein		 CTD PMID:38599287 NCBI chr15:51,429,518...51,460,308
Ensembl chr15:51,429,549...51,460,310 		JBrowse link
G Or5ac16 olfactory receptor family 5 subfamily AC member 16 decreases expression ISO Propofol results in decreased expression of OR5AC16 mRNA CTD PMID:21786383
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [Propofol results in increased susceptibility to STA 9090] which results in increased cleavage of PARP1 protein CTD PMID:24784839 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression
multiple interactions		 ISO Propofol results in decreased expression of PCNA protein
CASC9 protein inhibits the reaction [Propofol results in decreased expression of PCNA protein]		 CTD PMID:35238236 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pea15 proliferation and apoptosis adaptor protein 15 decreases expression
multiple interactions		 EXP Propofol results in decreased expression of PEA15 mRNA; Propofol results in decreased expression of PEA15 protein
PEA15 protein inhibits the reaction [Propofol results in decreased expression of BCL2 protein]; PEA15 protein inhibits the reaction [Propofol results in decreased expression of CASP3 protein]; PEA15 protein inhibits the reaction [Propofol results in decreased expression of RPS6KA3 protein]; PEA15 protein inhibits the reaction [Propofol results in decreased phosphorylation of CREB1 protein]; PEA15 protein inhibits the reaction [Propofol results in decreased phosphorylation of MAPK1 protein]; PEA15 protein inhibits the reaction [Propofol results in decreased phosphorylation of MAPK3 protein]; PEA15 protein inhibits the reaction [Propofol results in increased cleavage of CASP3 protein]; PEA15 protein inhibits the reaction [Propofol results in increased expression of BAX protein]		 CTD PMID:31257496 NCBI chr13:84,657,815...84,667,437
Ensembl chr13:84,654,870...84,667,499 		JBrowse link
G Pkd1l3 polycystin 1 like 3, transient receptor potential channel interacting decreases expression ISO Propofol results in decreased expression of PKD1L3 mRNA CTD PMID:35238236 NCBI chr19:37,585,564...37,650,083
Ensembl chr19:37,585,725...37,650,155 		JBrowse link
G Pla2g2c phospholipase A2, group IIC increases expression ISO Propofol results in increased expression of PLA2G2C mRNA CTD PMID:35238236 NCBI chr 5:150,959,365...150,981,388
Ensembl chr 5:150,959,182...150,981,377 		JBrowse link
G Pln phospholamban decreases phosphorylation EXP Propofol results in decreased phosphorylation of PLN protein CTD PMID:27495954 NCBI chr20:32,629,537...32,639,559 JBrowse link
G Pnn pinin, desmosome associated protein multiple interactions
decreases expression		 ISO Lipopolysaccharides inhibits the reaction [Propofol results in decreased expression of PNN mRNA] CTD PMID:35953652 NCBI chr 6:76,758,138...76,766,451
Ensembl chr 6:76,758,117...76,766,889 		JBrowse link
G Prkcd protein kinase C, delta multiple interactions EXP Propofol inhibits the reaction [Doxorubicin results in increased cleavage of PRKCD protein] CTD PMID:22015447 NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352 		JBrowse link
G Prl prolactin increases secretion ISO Propofol results in increased secretion of PRL protein CTD PMID:18482853 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Pten phosphatase and tensin homolog increases expression
multiple interactions		 ISO Propofol results in increased expression of PTEN protein
CASC9 protein inhibits the reaction [Propofol results in increased expression of PTEN protein]		 CTD PMID:35238236 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions ISO Propofol inhibits the reaction [lipoteichoic acid results in increased phosphorylation of RAF1 protein] CTD PMID:19573522 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317 		JBrowse link
G Ren renin multiple interactions ISO [Propofol co-treated with desflurane] results in increased expression of REN protein CTD PMID:8017643 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
G Rnu12 RNA, U12 small nuclear decreases expression ISO Propofol results in decreased expression of RNU12 mRNA CTD PMID:35238236 NCBI chr 7:114,303,546...114,303,696
Ensembl chr 7:114,303,546...114,303,696 		JBrowse link
G Rorb RAR-related orphan receptor B multiple interactions
decreases expression		 ISO Lipopolysaccharides inhibits the reaction [Propofol results in decreased expression of RORB mRNA] CTD PMID:35953652 NCBI chr 1:216,363,629...216,544,390
Ensembl chr 1:216,363,629...216,544,390 		JBrowse link
G Rps6ka3 ribosomal protein S6 kinase A3 decreases expression
multiple interactions		 EXP Propofol results in decreased expression of RPS6KA3 protein
PEA15 protein inhibits the reaction [Propofol results in decreased expression of RPS6KA3 protein]		 CTD PMID:31257496 NCBI chr  X:35,517,306...35,623,296
Ensembl chr  X:35,517,306...35,623,207 		JBrowse link
G Rpsa ribosomal protein SA increases expression
multiple interactions		 ISO Propofol results in increased expression of RPSA mRNA
Lipopolysaccharides promotes the reaction [Propofol results in increased expression of RPSA mRNA]		 CTD PMID:35953652 NCBI chr 8:119,851,225...119,855,103
Ensembl chr 8:119,851,225...119,855,247 		JBrowse link
G Ryr2 ryanodine receptor 2 decreases phosphorylation EXP Propofol results in decreased phosphorylation of RYR2 protein CTD PMID:27495954 NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142 		JBrowse link
G Serpinf1 serpin family F member 1 increases expression ISO Propofol results in increased expression of SERPINF1 protein CTD PMID:36207479 NCBI chr10:60,250,198...60,262,593
Ensembl chr10:60,249,708...60,262,646 		JBrowse link
G Set Set nuclear proto-oncogene decreases expression
multiple interactions		 ISO Propofol results in decreased expression of SET mRNA
Lipopolysaccharides inhibits the reaction [Propofol results in decreased expression of SET mRNA]		 CTD PMID:35953652 NCBI chr 3:13,334,564...13,345,598
Ensembl chr 3:13,335,041...13,363,567 		JBrowse link
G Slc1a1 solute carrier family 1 member 1 multiple interactions EXP [Tetradecanoylphorbol Acetate co-treated with Propofol] inhibits the reaction [tert-Butylhydroperoxide results in decreased activity of SLC1A1 protein] CTD PMID:17382927 NCBI chr 1:226,549,932...226,631,925
Ensembl chr 1:226,549,842...226,630,402 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 decreases expression ISO Propofol results in decreased expression of SLC2A1 protein CTD PMID:36207479 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416 		JBrowse link
G Slc38a3 solute carrier family 38, member 3 decreases expression ISO Propofol results in decreased expression of SLC38A3 mRNA CTD PMID:35238236 NCBI chr 8:108,323,889...108,339,959
Ensembl chr 8:108,323,894...108,339,988 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 decreases expression ISO Propofol results in decreased expression of SLC6A3 protein CTD PMID:32612007 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 decreases expression
multiple interactions		 EXP Propofol results in decreased expression of SLC7A11 protein
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid inhibits the reaction [Propofol results in decreased expression of SLC7A11 protein]		 CTD PMID:28663055 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Smad2 SMAD family member 2 multiple interactions
decreases expression		 ISO Lipopolysaccharides inhibits the reaction [Propofol results in decreased expression of SMAD2 mRNA] CTD PMID:35953652 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323 		JBrowse link
G Snap25 synaptosome associated protein 25 multiple interactions EXP SNAP25 protein affects the reaction [Propofol affects the localization of STX1A protein] CTD PMID:29320738 NCBI chr 3:124,041,898...124,123,761
Ensembl chr 3:124,041,898...124,123,760 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP Propofol inhibits the reaction [Doxorubicin results in decreased expression of SOD1 protein] CTD PMID:22015447 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 increases expression
multiple interactions		 EXP Propofol results in increased expression of SOD2 protein
Propofol inhibits the reaction [Doxorubicin results in decreased expression of SOD2 protein]		 CTD PMID:21468576 PMID:22015447 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase increases expression ISO Propofol results in increased expression of SRC mRNA CTD PMID:35953652 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Srd5a2 steroid 5 alpha-reductase 2 decreases expression ISO Propofol results in decreased expression of SRD5A2 mRNA CTD PMID:35238236 NCBI chr 6:21,426,225...21,465,727
Ensembl chr 6:21,426,215...21,462,112 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
increases phosphorylation
decreases phosphorylation		 EXP
ISO		 HMOX1 protein affects the reaction [Propofol inhibits the reaction [Glucose results in decreased phosphorylation of STAT3 protein]]; Propofol inhibits the reaction [Glucose results in decreased phosphorylation of STAT3 protein]; Propofol promotes the reaction [Streptozocin results in decreased phosphorylation of STAT3 protein]; STAT3 protein affects the reaction [Propofol inhibits the reaction [Glucose results in increased cleavage of CASP3 protein]]; STAT3 protein affects the reaction [Propofol inhibits the reaction [Glucose results in increased expression of ACTA1 mRNA]]; STAT3 protein affects the reaction [Propofol inhibits the reaction [Glucose results in increased expression of NPPA mRNA]]; zinc protoporphyrin inhibits the reaction [Propofol inhibits the reaction [Glucose results in decreased phosphorylation of STAT3 protein]]
Propofol results in increased phosphorylation of STAT3 protein
Propofol decreases phosphorylation of STAT3 protein in colon epithelium		 CTD
RGD		 PMID:24810525 PMID:32386021 RGD:125097524 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Stx1a syntaxin 1A multiple interactions
affects localization		 EXP Propofol inhibits the reaction [barium chloride affects the localization of STX1A protein]; SNAP25 protein affects the reaction [Propofol affects the localization of STX1A protein]; STX1A protein modified form inhibits the reaction [Propofol affects the localization of STX1A protein]; STX1A protein modified form inhibits the reaction [Propofol inhibits the reaction [barium chloride affects the localization of STX1A protein]] CTD PMID:29320738 NCBI chr12:21,641,971...21,670,022
Ensembl chr12:21,641,969...21,669,930 		JBrowse link
G Tdh L-threonine dehydrogenase decreases expression ISO Propofol results in decreased expression of TDH mRNA CTD PMID:21786383 NCBI chr15:37,739,823...37,753,365
Ensembl chr15:37,739,823...37,753,365 		JBrowse link
G Th tyrosine hydroxylase decreases expression ISO Propofol results in decreased expression of TH protein CTD PMID:32612007 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 increases expression
multiple interactions		 ISO Propofol results in increased expression of TIMP2 mRNA; Propofol results in increased expression of TIMP2 protein
Lipopolysaccharides promotes the reaction [Propofol results in increased expression of TIMP2 mRNA]		 CTD PMID:35953652 NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611 		JBrowse link
G Tincr TINCR ubiquitin domain containing increases expression ISO Propofol results in increased expression of TINCR mRNA CTD PMID:35238236 NCBI chr 9:1,387,105...1,389,337 JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA]; Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]; TLR4 protein affects the reaction [Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]] CTD PMID:19433076 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tmc6 transmembrane channel like 6 increases expression ISO Propofol results in increased expression of TMC6 mRNA CTD PMID:35238236 NCBI chr10:102,982,059...102,999,509
Ensembl chr10:102,971,229...102,998,960 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; TLR4 protein affects the reaction [Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]] CTD PMID:19433076 PMID:21307008 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression		 EXP
ISO		 Propofol inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]
Propofol results in increased expression of TP53 protein		 CTD PMID:22015447 PMID:28804952 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 decreases expression
multiple interactions		 EXP Propofol results in decreased expression of TRPC6 protein
1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole promotes the reaction [Propofol results in decreased expression of TRPC6 protein]; hyperforin inhibits the reaction [Propofol results in decreased expression of TRPC6 protein]		 CTD PMID:36640868 NCBI chr 8:5,759,387...5,864,000
Ensembl chr 8:5,758,935...5,828,092 		JBrowse link
G Ugt1a7c UDP glucuronosyltransferase 1 family, polypeptide A7C increases glucuronidation EXP UGT1A7 protein results in increased glucuronidation of Propofol CTD PMID:15502008 NCBI chr 9:88,739,577...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 decreases activity
affects metabolic processing
increases glucuronidation
multiple interactions		 ISO Propofol results in decreased activity of UGT1A9 protein
UGT1A9 protein affects the metabolism of Propofol
UGT1A9 protein results in increased glucuronidation of Propofol
[Warfarin binds to and affects the activity of UGT1A9 protein] which affects the glucuronidation of Propofol; licochalcone A inhibits the reaction [UGT1A9 protein results in increased glucuronidation of Propofol]; shikonin inhibits the reaction [UGT1A9 protein results in increased glucuronidation of Propofol]; Warfarin affects the reaction [UGT1A9 protein results in increased glucuronidation of Propofol]		 CTD PMID:12756209 PMID:14570768 PMID:15286053 PMID:15378558 PMID:15769885 More... NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Uhrf1 ubiquitin-like with PHD and ring finger domains 1 increases expression ISO Propofol results in increased expression of UHRF1 mRNA CTD PMID:35238236 NCBI chr 9:1,133,117...1,154,639
Ensembl chr 9:1,134,909...1,154,631 		JBrowse link
G Vim vimentin multiple interactions ISO Propofol affects the reaction [LINC01133 affects the expression of VIM protein] CTD PMID:38146619 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
G Xist X inactive specific transcript increases expression ISO Propofol results in increased expression of XIST mRNA CTD PMID:35238236 NCBI chr  X:68,474,987...68,492,500 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      chemical role 19479
        antioxidant 16148
          radical scavenger 6706
            propofol 165
              4-hydroxypropofol 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            organic molecule 19706
                              organic cyclic compound 19495
                                organic aromatic compound 19360
                                  phenols 18655
                                    propofol 165
                                      4-hydroxypropofol 0
paths to the root