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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:dexmedetomidine
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Accession:CHEBI:4466 term browser browse the term
Definition:A medetomidine that has formula C13H16N2.
Synonyms:exact_synonym: 4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole
 related_synonym: (+)-4-((S)-alpha,2,3-trimethylbenzyl)imidazole;   Formula=C13H16N2;   InChI=1S/C13H16N2/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13/h4-8,11H,1-3H3,(H,14,15)/t11-/m0/s1;   InChIKey=CUHVIMMYOGQXCV-NSHDSACASA-N;   MPV 1440;   SMILES=C[C@H](c1c[nH]cn1)c1cccc(C)c1C;   dexmedetomidina;   dexmedetomidinum
 xref: Beilstein:5906875;   CAS:113775-47-6;   DrugBank:DB00633;   Drug_Central:835;   KEGG:C07450;   KEGG:D00514
 xref_mesh: MESH:D020927
 xref: Patent:GB2206880;   Patent:US4910214;   Wikipedia:Dexmedetomidine
 cyclic_relationship: is_enantiomer_of CHEBI:48555


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dexmedetomidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra2a adrenoceptor alpha 2A multiple interactions ISO Dexmedetomidine binds to and results in increased activity of ADRA2A protein; Dexmedetomidine inhibits the reaction [Norepinephrine binds to and results in increased activity of ADRA2A protein] CTD PMID:10742289 PMID:15627480 NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP atipamezole inhibits the reaction [Dexmedetomidine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of BAX protein]]; Dexmedetomidine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of BAX protein] CTD PMID:30597158 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Dexmedetomidine inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein]; Dexmedetomidine inhibits the reaction [Hydrogen Peroxide results in increased expression of BCL2 mRNA]; Dexmedetomidine inhibits the reaction [Isoflurane results in decreased expression of BCL2 protein]; Dexmedetomidine inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]; MIR134 inhibits the reaction [Dexmedetomidine inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein]]; MIR134 inhibits the reaction [Dexmedetomidine inhibits the reaction [Hydrogen Peroxide results in increased expression of BCL2 mRNA]] CTD PMID:20003127 PMID:34121490 PMID:36075570 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions EXP atipamezole inhibits the reaction [Dexmedetomidine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of BCL2L1 protein]]; Dexmedetomidine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of BCL2L1 protein] CTD PMID:30597158 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479 		JBrowse link
G Casp1 caspase 1 multiple interactions ISO Dexmedetomidine inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP1 protein]
Dexmedetomidine inhibits the reaction [Ropivacaine results in increased cleavage of CASP1 protein]; NFE2L2 protein promotes the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased cleavage of CASP1 protein]]; zinc protoporphyrin inhibits the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased cleavage of CASP1 protein]]		 CTD PMID:30102002 PMID:36858639 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions		 ISO
EXP		 Dexmedetomidine results in increased activity of CASP3 protein
atipamezole inhibits the reaction [Dexmedetomidine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased cleavage of CASP3 protein]]; Dexmedetomidine inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein]; Dexmedetomidine inhibits the reaction [Isoflurane results in increased expression of CASP3 protein]; Dexmedetomidine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased cleavage of CASP3 protein]; Dexmedetomidine inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP3 protein]; MIR134 inhibits the reaction [Dexmedetomidine inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein]]		 CTD PMID:18724006 PMID:19352168 PMID:20003127 PMID:30597158 PMID:34121490 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 increases activity ISO Dexmedetomidine results in increased activity of CASP7 protein CTD PMID:18724006 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp8 caspase 8 increases activity ISO Dexmedetomidine results in increased activity of CASP8 protein CTD PMID:18724006 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases activity ISO Dexmedetomidine results in increased activity of CASP9 protein CTD PMID:18724006 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Dexmedetomidine inhibits the reaction [Ethanol results in increased expression of CCL2 mRNA] CTD PMID:31954762 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 multiple interactions EXP Dexmedetomidine inhibits the reaction [Propofol results in increased expression of CDK5R1 protein] CTD PMID:31187143 NCBI chr10:65,484,266...65,485,467
Ensembl chr10:65,483,941...65,488,456 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Dexmedetomidine promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA] CTD PMID:15627480 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions EXP atipamezole inhibits the reaction [Dexmedetomidine promotes the reaction [Benzo(a)pyrene results in increased expression of and results in increased activity of CYP1A2 protein]]; atipamezole inhibits the reaction [Dexmedetomidine promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]]; Dexmedetomidine promotes the reaction [Benzo(a)pyrene results in increased expression of and results in increased activity of CYP1A2 protein]; Dexmedetomidine promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA] CTD PMID:16510159 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 multiple interactions EXP Dexmedetomidine inhibits the reaction [Propofol results in increased phosphorylation of DPYSL2 protein] CTD PMID:31187143 NCBI chr15:41,005,551...41,111,724
Ensembl chr15:41,005,551...41,111,829 		JBrowse link
G Dusp1 dual specificity phosphatase 1 multiple interactions EXP atipamezole inhibits the reaction [Dexmedetomidine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of DUSP1 protein]]; Dexmedetomidine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of DUSP1 protein] CTD PMID:30597158 NCBI chr10:16,680,478...16,683,275 JBrowse link
G Foxo3 forkhead box O3 multiple interactions EXP Dexmedetomidine inhibits the reaction [Lidocaine results in increased expression of FOXO3 protein] CTD PMID:32228195 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP Dexmedetomidine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of GPT protein] CTD PMID:30597158 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gsdmd gasdermin D multiple interactions ISO Dexmedetomidine inhibits the reaction [Ropivacaine results in increased cleavage of GSDMD protein]; NFE2L2 protein promotes the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased cleavage of GSDMD protein]]; zinc protoporphyrin inhibits the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased cleavage of GSDMD protein]] CTD PMID:36858639 NCBI chr 7:107,542,489...107,547,051
Ensembl chr 7:107,542,083...107,547,055 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
increases phosphorylation		 EXP atipamezole inhibits the reaction [Dexmedetomidine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased phosphorylation of GSK3B protein]]; Dexmedetomidine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased phosphorylation of GSK3B protein]; Dexmedetomidine inhibits the reaction [Propofol results in decreased phosphorylation of and results in increased activity of GSK3B protein]
Dexmedetomidine results in increased phosphorylation of GSK3B protein		 CTD PMID:30597158 PMID:31187143 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression		 EXP
ISO		 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dexmedetomidine inhibits the reaction [Isoflurane results in decreased expression of and results in decreased activity of HMOX1 protein]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dexmedetomidine inhibits the reaction [Isoflurane results in decreased expression of HMOX1 mRNA]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dexmedetomidine inhibits the reaction [Isoflurane results in decreased expression of HMOX1 protein]]; atipamezole inhibits the reaction [Dexmedetomidine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of HMOX1 protein]]; Dexmedetomidine inhibits the reaction [Isoflurane results in decreased expression of and results in decreased activity of HMOX1 protein]; Dexmedetomidine inhibits the reaction [Isoflurane results in decreased expression of HMOX1 mRNA]; Dexmedetomidine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of HMOX1 protein]; Dexmedetomidine results in increased expression of and results in increased activity of HMOX1 protein
Dexmedetomidine results in increased expression of HMOX1 mRNA
Dexmedetomidine promotes the reaction [Ropivacaine results in increased expression of HMOX1 protein]; NFE2L2 protein promotes the reaction [Dexmedetomidine promotes the reaction [Ropivacaine results in increased expression of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [Dexmedetomidine promotes the reaction [Ropivacaine results in increased expression of HMOX1 protein]]		 CTD PMID:30597158 PMID:36027947 PMID:36858639 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 multiple interactions EXP Dexmedetomidine affects the reaction [MIR330 protein affects the expression of HSPD1 mRNA]; Dexmedetomidine inhibits the reaction [Sevoflurane results in decreased expression of HSPD1 mRNA]; Dexmedetomidine inhibits the reaction [Sevoflurane results in decreased expression of HSPD1 protein] CTD PMID:34590382 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662 		JBrowse link
G Il18 interleukin 18 multiple interactions ISO Dexmedetomidine inhibits the reaction [Ropivacaine results in increased expression of IL18 protein]; NFE2L2 protein promotes the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased expression of IL18 protein]]; zinc protoporphyrin inhibits the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased expression of IL18 protein]] CTD PMID:36858639 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Dexmedetomidine inhibits the reaction [Ethanol results in increased expression of IL1B mRNA]; Dexmedetomidine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; MIR381 mRNA affects the reaction [Dexmedetomidine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]
Dexmedetomidine inhibits the reaction [Ropivacaine results in increased expression of IL1B protein]; NFE2L2 protein promotes the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased expression of IL1B protein]]; zinc protoporphyrin inhibits the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased expression of IL1B protein]]		 CTD PMID:30102002 PMID:31954762 PMID:36858639 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP
ISO		 Dexmedetomidine inhibits the reaction [Hydrogen Peroxide results in increased expression of IL6 mRNA]; Dexmedetomidine inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL6 protein]; Dexmedetomidine inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Dexmedetomidine promotes the reaction [prolinedithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; MIR134 inhibits the reaction [Dexmedetomidine inhibits the reaction [Hydrogen Peroxide results in increased expression of IL6 mRNA]]; prolinedithiocarbamate promotes the reaction [Dexmedetomidine inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]
Dexmedetomidine inhibits the reaction [Ethanol results in increased expression of IL6 mRNA]		 CTD PMID:29723264 PMID:31954762 PMID:34121490 PMID:36075570 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ldha lactate dehydrogenase A multiple interactions ISO Dexmedetomidine inhibits the reaction [Ropivacaine results in increased expression of LDHA protein]; NFE2L2 protein promotes the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased expression of LDHA protein]]; zinc protoporphyrin inhibits the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased expression of LDHA protein]] CTD PMID:36858639 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions EXP Dexmedetomidine affects the reaction [MIR330 protein affects the lipidation of MAP1LC3B protein]; Dexmedetomidine inhibits the reaction [Sevoflurane results in decreased lipidation of MAP1LC3B protein] CTD PMID:34590382 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dexmedetomidine inhibits the reaction [Isoflurane results in decreased phosphorylation of MAPK1 protein]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Dexmedetomidine inhibits the reaction [Isoflurane results in decreased phosphorylation of MAPK1 protein]]; Dexmedetomidine inhibits the reaction [Isoflurane results in decreased phosphorylation of MAPK1 protein] CTD PMID:36027947 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mir134 microRNA 134 multiple interactions EXP Dexmedetomidine inhibits the reaction [Hydrogen Peroxide results in increased expression of MIR134 mRNA]; MIR134 inhibits the reaction [Dexmedetomidine inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein]]; MIR134 inhibits the reaction [Dexmedetomidine inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein]]; MIR134 inhibits the reaction [Dexmedetomidine inhibits the reaction [Hydrogen Peroxide results in increased expression of BCL2 mRNA]]; MIR134 inhibits the reaction [Dexmedetomidine inhibits the reaction [Hydrogen Peroxide results in increased expression of IL6 mRNA]]; MIR134 inhibits the reaction [Dexmedetomidine inhibits the reaction [Hydrogen Peroxide results in increased expression of TNF mRNA]] CTD PMID:34121490 NCBI chr 6:128,748,908...128,748,980 JBrowse link
G Mir330 microRNA 330 multiple interactions EXP Dexmedetomidine affects the reaction [MIR330 protein affects the expression of HSPD1 mRNA]; Dexmedetomidine affects the reaction [MIR330 protein affects the lipidation of MAP1LC3B protein]; Dexmedetomidine inhibits the reaction [Sevoflurane results in increased expression of MIR330 mRNA] CTD PMID:34590382 NCBI chr 1:78,833,178...78,833,274
Ensembl chr 1:78,833,178...78,833,274 		JBrowse link
G Mir34a microRNA 34a decreases response to substance EXP MIR34A mRNA results in decreased susceptibility to Dexmedetomidine CTD PMID:35527005 NCBI chr 5:160,533,002...160,533,103
Ensembl chr 5:160,533,002...160,533,103 		JBrowse link
G Mir381 microRNA 381 multiple interactions ISO [Dexmedetomidine co-treated with Lipopolysaccharides] results in increased expression of MIR381 mRNA; MIR381 mRNA affects the reaction [Dexmedetomidine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]; MIR381 mRNA affects the reaction [Dexmedetomidine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]] CTD PMID:30102002 NCBI chr 6:128,740,976...128,741,036 JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases phosphorylation
increases expression		 EXP
ISO		 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dexmedetomidine inhibits the reaction [Isoflurane results in decreased expression of NFE2L2 mRNA]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dexmedetomidine inhibits the reaction [Isoflurane results in decreased expression of NFE2L2 protein]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dexmedetomidine inhibits the reaction [Isoflurane results in decreased phosphorylation of NFE2L2 protein]]; atipamezole inhibits the reaction [Dexmedetomidine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of NFE2L2 protein]]; Dexmedetomidine inhibits the reaction [Isoflurane results in decreased expression of NFE2L2 mRNA]; Dexmedetomidine inhibits the reaction [Isoflurane results in decreased expression of NFE2L2 protein]; Dexmedetomidine inhibits the reaction [Isoflurane results in decreased phosphorylation of NFE2L2 protein]; Dexmedetomidine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of NFE2L2 protein]
Dexmedetomidine results in increased phosphorylation of NFE2L2 protein
Dexmedetomidine results in increased expression of NFE2L2 mRNA; Dexmedetomidine results in increased expression of NFE2L2 protein
Dexmedetomidine promotes the reaction [Ropivacaine results in increased expression of and results in increased localization of NFE2L2 protein]; NFE2L2 protein promotes the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased cleavage of CASP1 protein]]; NFE2L2 protein promotes the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased cleavage of GSDMD protein]]; NFE2L2 protein promotes the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased expression of IL18 protein]]; NFE2L2 protein promotes the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased expression of IL1B protein]]; NFE2L2 protein promotes the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased expression of LDHA protein]]; NFE2L2 protein promotes the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased expression of NLRP3 protein]]; NFE2L2 protein promotes the reaction [Dexmedetomidine promotes the reaction [Ropivacaine results in increased expression of HMOX1 protein]]		 CTD PMID:30597158 PMID:36027947 PMID:36858639 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO Dexmedetomidine inhibits the reaction [Lipopolysaccharides results in increased expression of NLRP3 protein]
Dexmedetomidine inhibits the reaction [Ropivacaine results in increased expression of NLRP3 protein]; NFE2L2 protein promotes the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased expression of NLRP3 protein]]		 CTD PMID:30102002 PMID:36858639 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP atipamezole inhibits the reaction [Dexmedetomidine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of NQO1 protein]]; Dexmedetomidine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of NQO1 protein] CTD PMID:30597158 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Prkcb protein kinase C, beta multiple interactions EXP Dexmedetomidine inhibits the reaction [Lidocaine results in increased expression of PRKCB protein] CTD PMID:30240660 NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Dexmedetomidine inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased phosphorylation of RELA protein] CTD PMID:29723264 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions EXP Dexmedetomidine inhibits the reaction [Lidocaine results in decreased expression of SIRT1 protein] CTD PMID:32228195 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dexmedetomidine inhibits the reaction [Isoflurane results in decreased expression of SOD1 protein]]; Dexmedetomidine inhibits the reaction [Isoflurane results in decreased expression of SOD1 protein] CTD PMID:36027947 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO		 Dexmedetomidine inhibits the reaction [Hydrogen Peroxide results in increased expression of TNF mRNA]; Dexmedetomidine inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of TNF protein]; Dexmedetomidine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Dexmedetomidine promotes the reaction [prolinedithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; MIR134 inhibits the reaction [Dexmedetomidine inhibits the reaction [Hydrogen Peroxide results in increased expression of TNF mRNA]]; prolinedithiocarbamate promotes the reaction [Dexmedetomidine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]
Dexmedetomidine inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; Dexmedetomidine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; MIR381 mRNA affects the reaction [Dexmedetomidine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]		 CTD PMID:29723264 PMID:30102002 PMID:31954762 PMID:34121490 PMID:36075570 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP atipamezole inhibits the reaction [Dexmedetomidine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TP53 protein]]; Dexmedetomidine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TP53 protein] CTD PMID:30597158 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 multiple interactions EXP Dexmedetomidine inhibits the reaction [Sevoflurane results in decreased expression of ULK1 mRNA] CTD PMID:34590382 NCBI chr12:45,851,710...45,877,966
Ensembl chr12:45,851,710...45,877,966 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      biological role 19848
        pharmacological role 19080
          analgesic 14774
            dexmedetomidine 39
              dexmedetomidine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            organic molecule 19706
                              organic cyclic compound 19495
                                organic heterocyclic compound 18874
                                  heteroarene 17155
                                    monocyclic heteroarene 14983
                                      azole 14506
                                        diazole 10772
                                          imidazoles 10221
                                            medetomidine 40
                                              dexmedetomidine 39
                                                dexmedetomidine hydrochloride 0
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