afimoxifene - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	afimoxifene	go back to main search page
Accession:	CHEBI:44616	browse the term
Definition:	A tertiary amino compound that is tamoxifen in which the phenyl group which is in a Z- relationship to the ethyl substituent is hydroxylated at the para- position. It is the active metabolite of tamoxifen.
Synonyms:	related_synonym:	4-HYDROXYTAMOXIFEN; 4-OHT; 4-monohydroxytamoxifen; Formula=C26H29NO2; InChI=1S/C26H29NO2/c1-4-25(20-8-6-5-7-9-20)26(21-10-14-23(28)15-11-21)22-12-16-24(17-13-22)29-19-18-27(2)3/h5-17,28H,4,18-19H2,1-3H3/b26-25-; InChIKey=TXUZVZSFRXZGTL-QPLCGJKRSA-N; SMILES=CC\\C(c1ccccc1)=C(/c1ccc(O)cc1)c1ccc(OCCN(C)C)cc1
	xref:	CAS:68047-06-3; CAS:68392-35-8; KEGG:C05011; KEGG:D06551
	xref_mesh:	MESH:C016601
	xref:	PDBeChem:OHT; PMID:15159443; PMID:16120301; PMID:17351746; PMID:20006599; PMID:22388692; PMID:26354796; PMID:27882656; PMID:30937657; PMID:31195002; PMID:31278729; PMID:31519767; PMID:32103133; PMID:32175001; Reaxys:4910748; Wikipedia:Afimoxifene

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Genes (619)

afimoxifene

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

4-aminobutyrate aminotransferase

decreases expression

afimoxifene results in decreased expression of ABAT mRNA

NCBI chr10:6,996,688...7,092,835
Ensembl chr10:6,999,819...7,092,835

G

ATP binding cassette subfamily B member 1A

decreases response to substance
multiple interactions
increases expression

ABCB1 protein results in decreased susceptibility to afimoxifene
[ALB protein co-treated with afimoxifene] results in increased expression of ABCB1 protein
afimoxifene results in increased expression of ABCB1 protein

PMID:34213887 PMID:35753429

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily C member 3

increases expression

afimoxifene results in increased expression of ABCC3 mRNA

NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595

G

ATP binding cassette subfamily C member 5

multiple interactions
increases expression

afimoxifene inhibits the reaction [Estrogens results in decreased expression of ABCC5 mRNA]
afimoxifene results in increased expression of ABCC5 mRNA

PMID:15072547 PMID:21233418

NCBI chr11:80,473,809...80,567,257
Ensembl chr11:80,473,872...80,567,253

G

ATP binding cassette subfamily G member 1

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of ABCG1 mRNA]

NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948

G

abhydrolase domain containing 17C, depalmitoylase

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of ABHD17C mRNA]

NCBI chr 1:138,084,632...138,125,595
Ensembl chr 1:138,084,634...138,125,595

G

atypical chemokine receptor 3

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of ACKR3 mRNA]

NCBI chr 9:90,799,682...90,811,246
Ensembl chr 9:90,799,686...90,811,237

G

adenosine deaminase

decreases expression

afimoxifene results in decreased expression of ADA mRNA

NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088

G

ADAM metallopeptidase with thrombospondin type 1 motif, 16

decreases expression

afimoxifene results in decreased expression of ADAMTS16 mRNA

NCBI chr 1:32,430,436...32,562,481
Ensembl chr 1:32,430,436...32,560,494

G

adenylate cyclase 9

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of ADCY9 mRNA]

NCBI chr10:11,138,966...11,262,067
Ensembl chr10:11,139,446...11,262,066

G

adhesion G protein-coupled receptor G1

increases expression

afimoxifene results in increased expression of ADGRG1 mRNA

NCBI chr19:10,003,963...10,041,122
Ensembl chr19:10,003,975...10,041,108

G

AHNAK nucleoprotein

decreases expression

afimoxifene results in decreased expression of AHNAK mRNA

NCBI chr 1:205,882,225...205,970,934
Ensembl chr 1:205,882,273...205,970,926

G

aryl hydrocarbon receptor

increases activity
multiple interactions

afimoxifene results in increased activity of AHR protein
afimoxifene promotes the reaction [AHR protein binds to ARNT protein]; afimoxifene promotes the reaction [AHR protein binds to CYP1A1 promoter]

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

aryl-hydrocarbon receptor repressor

increases expression

afimoxifene results in increased expression of AHRR mRNA

NCBI chr 1:28,993,634...29,088,673
Ensembl chr 1:28,993,634...29,088,673

G

adenylate kinase 2

decreases response to substance

AK2 results in decreased susceptibility to afimoxifene

NCBI chr 5:141,308,650...141,364,633
Ensembl chr 5:141,346,063...141,364,632

G

adenylate kinase 5

decreases response to substance

AK5 results in decreased susceptibility to afimoxifene

NCBI chr 2:241,397,297...241,581,483
Ensembl chr 2:241,397,297...241,581,458

G

AKT serine/threonine kinase 1

increases phosphorylation
decreases response to substance
multiple interactions

afimoxifene results in increased phosphorylation of AKT1 protein
AKT1 protein results in decreased susceptibility to afimoxifene
afimoxifene inhibits the reaction [icariin results in increased phosphorylation of AKT1 protein]

PMID:18351453 PMID:19549922 PMID:35259346

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

AKT serine/threonine kinase 2

decreases response to substance

AKT2 protein results in decreased susceptibility to afimoxifene

NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817

G

aminolevulinate dehydratase

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of ALAD mRNA]

NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474

G

albumin

multiple interactions

[ALB protein co-treated with afimoxifene] results in increased expression of ABCB1 protein

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

arachidonate 5-lipoxygenase

multiple interactions

[afimoxifene co-treated with 4-hydroxycyclophosphamide] affects the expression of ALOX5 mRNA

NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743

G

adenosylmethionine decarboxylase 1

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of AMD1 mRNA]

NCBI chr20:43,695,783...43,711,476
Ensembl chr20:43,697,237...43,711,476

G

ankyrin 3

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of ANK3 mRNA]

NCBI chr20:18,602,267...19,225,831
Ensembl chr20:18,602,786...19,086,300

G

apolipoprotein D

increases expression

afimoxifene results in increased expression of APOD mRNA

NCBI chr11:69,431,261...69,452,306
Ensembl chr11:69,431,260...69,452,305

G

androgen receptor

decreases activity
multiple interactions

afimoxifene results in decreased activity of AR protein
afimoxifene inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]

PMID:9846162 PMID:33049310

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

amphiregulin

decreases expression
increases expression

afimoxifene results in decreased expression of AREG mRNA
afimoxifene results in increased expression of AREG mRNA

PMID:15072547 PMID:16514628

NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535

G

AT-rich interaction domain 5A

multiple interactions

ARID5A protein inhibits the reaction [afimoxifene results in increased activity of ESR1 protein]

NCBI chr 9:38,534,612...38,549,467
Ensembl chr 9:38,534,590...38,547,597

G

aryl hydrocarbon receptor nuclear translocator

multiple interactions

afimoxifene promotes the reaction [AHR protein binds to ARNT protein]

NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580

G

aryl hydrocarbon receptor nuclear translocator 2

increases expression

afimoxifene results in increased expression of ARNT2 mRNA

NCBI chr 1:138,236,235...138,392,868
Ensembl chr 1:138,189,940...138,393,153

G

achaete-scute family bHLH transcription factor 1

decreases expression
increases expression

afimoxifene results in decreased expression of ASCL1 mRNA
afimoxifene results in increased expression of ASCL1 mRNA

PMID:16849584 PMID:19901195

NCBI chr 7:21,903,136...21,906,003
Ensembl chr 7:21,903,126...21,905,993

G

asparagine synthetase (glutamine-hydrolyzing)

decreases expression

afimoxifene results in decreased expression of ASNS mRNA

NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423

G

activating transcription factor 3

increases expression
multiple interactions

afimoxifene results in increased expression of ATF3 mRNA
GPER1 protein affects the reaction [afimoxifene results in increased expression of ATF3 mRNA]

NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631

G

ATPase phospholipid transporting 8B2

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of ATP8B2 mRNA]

NCBI chr 2:175,378,514...175,402,265
Ensembl chr 2:175,378,517...175,401,883

G

ATR serine/threonine kinase

decreases response to substance

ATR results in decreased susceptibility to afimoxifene

NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136

G

aurora kinase A

decreases expression
decreases response to substance

afimoxifene results in decreased expression of AURKA mRNA
AURKA results in decreased susceptibility to afimoxifene

PMID:16514628 PMID:21233418

NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390

G

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2

increases expression

afimoxifene results in increased expression of B3GNT2 mRNA

NCBI chr14:96,808,473...96,833,674
Ensembl chr14:96,806,664...96,835,273

G

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8

decreases expression

afimoxifene results in decreased expression of B3GNT8 mRNA

NCBI chr 1:81,135,602...81,138,501
Ensembl chr 1:81,135,499...81,142,263

G

BRCA1 associated deubiquitinase 1

affects response to substance

BAP1 gene affects the susceptibility to afimoxifene

NCBI chr16:6,446,709...6,455,535
Ensembl chr16:6,446,709...6,455,535

G

Bardet-Biedl syndrome 5

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of BBS5 mRNA]

NCBI chr 3:54,410,429...54,431,831
Ensembl chr 3:54,410,775...54,431,829

G

BCAR1 scaffold protein, Cas family member

decreases response to substance

BCAR1 protein results in decreased susceptibility to afimoxifene

NCBI chr19:39,679,215...39,713,907
Ensembl chr19:39,679,204...39,713,907

G

BCAR3 adaptor protein, NSP family member

multiple interactions
decreases response to substance

afimoxifene inhibits the reaction [Estrogens results in decreased expression of BCAR3 mRNA]
BCAR3 protein results in decreased susceptibility to afimoxifene

PMID:18351453 PMID:21233418

NCBI chr 2:210,525,260...210,638,674
Ensembl chr 2:210,525,260...210,638,798

G

BCL2, apoptosis regulator

decreases expression
multiple interactions

afimoxifene results in decreased expression of BCL2 mRNA
[annonacin co-treated with afimoxifene] results in decreased expression of BCL2 protein

PMID:19698761 PMID:21840388

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

increases expression

afimoxifene results in increased expression of BCL2L1 mRNA

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

G

BCL3, transcription coactivator

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of BCL3 mRNA]

NCBI chr 1:79,471,368...79,485,908
Ensembl chr 1:79,471,369...79,485,607

G

BCL9 like

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of BCL9L mRNA]

NCBI chr 8:44,811,977...44,840,611
Ensembl chr 8:44,811,977...44,840,611

G

bradykinin receptor B2

multiple interactions

[afimoxifene co-treated with 4-hydroxycyclophosphamide] affects the expression of BDKRB2 mRNA

NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497

G

basic helix-loop-helix family, member e40

increases expression
multiple interactions

afimoxifene results in increased expression of BHLHE40 mRNA
GPER1 protein affects the reaction [afimoxifene results in increased expression of BHLHE40 mRNA]

PMID:16849584 PMID:19153601

NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774

G

BCL2-interacting killer

increases expression

afimoxifene results in increased expression of BIK mRNA

NCBI chr 7:114,672,277...114,691,296
Ensembl chr 7:114,672,277...114,691,296

G

BLK proto-oncogene, Src family tyrosine kinase

decreases response to substance

BLK results in decreased susceptibility to afimoxifene

NCBI chr15:37,626,746...37,665,053
Ensembl chr15:37,627,039...37,665,031

G

B-cell linker

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of BLNK mRNA]

NCBI chr 1:239,753,640...239,821,113
Ensembl chr 1:239,753,648...239,821,113

G

biliverdin reductase B

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of BLVRB mRNA]

NCBI chr 1:82,738,646...82,756,312
Ensembl chr 1:82,738,695...82,770,375

G

bone morphogenetic protein 7

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of BMP7 mRNA]

NCBI chr 3:161,639,915...161,716,938
Ensembl chr 3:161,516,462...161,716,788

G

biorientation of chromosomes in cell division 1

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of BOD1 mRNA]

NCBI chr10:15,993,454...15,999,795
Ensembl chr10:15,993,454...15,999,787

G

BOP1 ribosomal biogenesis factor

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of BOP1 mRNA]

NCBI chr 7:108,172,062...108,195,875
Ensembl chr 7:108,172,066...108,195,931

G

B-Raf proto-oncogene, serine/threonine kinase

multiple interactions

[BRAF protein co-treated with afimoxifene] results in increased expression of and results in increased activity of EGR1 protein; [BRAF protein co-treated with afimoxifene] results in increased phosphorylation of MAPK1 protein; [BRAF protein co-treated with afimoxifene] results in increased phosphorylation of MAPK3 protein

NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463

G

bromodomain containing 2

decreases response to substance

BRD2 results in decreased susceptibility to afimoxifene

NCBI chr20:4,727,078...4,735,389
Ensembl chr20:4,728,151...4,735,388

G

BTG anti-proliferation factor 1

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of BTG1 mRNA]

NCBI chr 7:31,341,391...31,343,649
Ensembl chr 7:31,341,027...31,343,649

G

similar to human chromosome 1 open reading frame 226

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of C1ORF226 mRNA]

NCBI chr13:82,530,589...82,538,676
Ensembl chr13:82,530,577...82,820,949

G

complement C3

increases expression

afimoxifene results in increased expression of C3 protein

NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429

G

calcitonin receptor

increases expression

afimoxifene results in increased expression of CALCR mRNA

NCBI chr 4:31,661,270...31,736,392
Ensembl chr 4:31,661,273...31,736,392

G

calmodulin 3

decreases response to substance

CALM3 results in decreased susceptibility to afimoxifene

NCBI chr 1:77,590,668...77,597,776
Ensembl chr 1:77,589,230...77,592,207

G

calcium/calmodulin-dependent protein kinase I

decreases response to substance

CAMK1 results in decreased susceptibility to afimoxifene

NCBI chr 4:146,481,196...146,492,039
Ensembl chr 4:146,481,196...146,492,081

G

cyclase associated actin cytoskeleton regulatory protein 2

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of CAP2 mRNA]

NCBI chr17:18,054,234...18,203,453
Ensembl chr17:18,054,431...18,203,373

G

carbonic anhydrase 12

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of CA12 mRNA]

NCBI chr 8:67,274,739...67,330,428
Ensembl chr 8:67,274,359...67,330,440

G

carbonic anhydrase 2

increases expression

afimoxifene results in increased expression of CA2 mRNA

NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818

G

caspase recruitment domain family, member 6

increases expression

afimoxifene results in increased expression of CARD6 mRNA

NCBI chr 2:54,194,343...54,206,902
Ensembl chr 2:54,195,739...54,206,846

G

chromobox 1

decreases expression

afimoxifene results in decreased expression of CBX1 mRNA

NCBI chr10:81,770,307...81,789,981
Ensembl chr10:81,770,342...81,791,096

G

coiled-coil domain containing 88C

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of CCDC88C mRNA]

NCBI chr 6:120,169,752...120,289,459
Ensembl chr 6:120,169,738...120,289,555

G

cellular communication network factor 1

multiple interactions
increases expression

GPER1 protein affects the reaction [afimoxifene results in increased expression of CCN1 mRNA]

NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484

G

cellular communication network factor 2

increases expression
multiple interactions
affects response to substance

afimoxifene results in increased expression of CCN2 mRNA; afimoxifene results in increased expression of CCN2 protein
GPER1 protein affects the reaction [afimoxifene results in increased expression of CCN2 mRNA]
CCN2 protein affects the susceptibility to afimoxifene

NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734

G

cellular communication network factor 3

decreases expression

afimoxifene results in decreased expression of CCN3 mRNA

NCBI chr 7:86,094,000...86,101,022
Ensembl chr 7:86,094,000...86,101,019

G

cyclin A1

increases expression

afimoxifene results in increased expression of CCNA1 mRNA

NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157

G

cyclin A2

increases expression

afimoxifene results in increased expression of CCNA2 mRNA

NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577

G

cyclin D1

decreases expression
multiple interactions
increases expression

afimoxifene results in decreased expression of CCND1 protein
[afimoxifene co-treated with lapatinib] results in decreased expression of CCND1 protein; afimoxifene inhibits the reaction [Estrogens results in increased expression of CCND1 mRNA]
afimoxifene results in increased expression of CCND1 mRNA

PMID:15665275 PMID:17640349 PMID:21233418

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin E1

multiple interactions
increases cleavage

[afimoxifene co-treated with lapatinib] promotes the reaction [CDKN1B protein binds to and results in decreased activity of [CCNE1 protein binds to CDK2 protein]]; afimoxifene promotes the reaction [CDKN1B protein binds to and results in decreased activity of [CCNE1 protein binds to CDK2 protein]]; GPER1 protein affects the reaction [afimoxifene results in increased cleavage of CCNE1 protein]; U 0126 inhibits the reaction [afimoxifene results in increased cleavage of CCNE1 protein]

PMID:15665275 PMID:23624423

NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101

G

cyclin E2

decreases expression

afimoxifene results in decreased expression of CCNE2 mRNA

NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632

G

cyclin G2

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of CCNG2 mRNA]

NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830

G

CD24 molecule

increases expression

afimoxifene results in increased expression of CD24 mRNA

NCBI chr20:47,074,353...47,079,662
Ensembl chr20:47,073,512...47,079,662

G

CD36 molecule

multiple interactions
decreases expression

PPARG mRNA promotes the reaction [afimoxifene results in decreased expression of CD36 protein]
afimoxifene inhibits the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in increased expression of CD36 protein]; afimoxifene inhibits the reaction [PPARG protein binds to CD36 promoter]; afimoxifene inhibits the reaction [PPARG protein results in increased expression of CD36 mRNA]; afimoxifene inhibits the reaction [Rosiglitazone results in increased expression of CD36 mRNA]; afimoxifene inhibits the reaction [Rosiglitazone results in increased expression of CD36 protein]; afimoxifene inhibits the reaction [Troglitazone results in increased expression of CD36 protein]; afimoxifene inhibits the reaction [U 0126 results in increased expression of CD36 protein]
afimoxifene results in decreased expression of CD36 mRNA; afimoxifene results in decreased expression of CD36 protein

NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903

G

CD40 molecule

multiple interactions

[afimoxifene co-treated with 4-hydroxycyclophosphamide] affects the expression of CD40 mRNA

NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534

G

CD44 molecule

increases expression

afimoxifene results in increased expression of CD44 mRNA

NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620

G

cell division cycle 6

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of CDC6 mRNA]

NCBI chr10:83,864,189...83,878,011
Ensembl chr10:83,864,638...83,878,011

G

cell division cycle associated 7

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of CDCA7 mRNA]

NCBI chr 3:57,322,718...57,333,353
Ensembl chr 3:57,322,708...57,333,353

G

cadherin 1

multiple interactions
increases expression

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[afimoxifene co-treated with EGF protein] results in increased expression of CDH1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [afimoxifene results in increased expression of CDH1 protein]; [afimoxifene co-treated with EGF protein] results in increased expression of CDH1 mRNA; [afimoxifene co-treated with EGF protein] results in increased expression of CDH1 protein; afimoxifene promotes the reaction [ESR1 protein binds to CDH1 promoter]; AG 1879 inhibits the reaction [[afimoxifene co-treated with EGF protein] results in increased expression of CDH1 protein]; AG 1879 inhibits the reaction [afimoxifene results in increased expression of CDH1 protein]; fulvestrant inhibits the reaction [[afimoxifene co-treated with EGF protein] results in increased expression of CDH1 protein]; fulvestrant inhibits the reaction [afimoxifene results in increased expression of CDH1 protein]; Plicamycin inhibits the reaction [afimoxifene promotes the reaction [ESR1 protein binds to CDH1 promoter]]
afimoxifene results in increased expression of CDH1 mRNA; afimoxifene results in increased expression of CDH1 protein

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

cadherin 11

decreases expression

afimoxifene results in decreased expression of CDH11 mRNA

NCBI chr19:2,148,447...2,305,754
Ensembl chr19:2,148,458...2,304,272

G

cyclin-dependent kinase 1

decreases response to substance
increases expression

CDK1 results in decreased susceptibility to afimoxifene
afimoxifene results in increased expression of CDK1 mRNA

PMID:19901195 PMID:21233418

NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408

G

cyclin-dependent kinase 18

increases expression

afimoxifene results in increased expression of CDK18 mRNA

NCBI chr13:43,555,597...43,582,210
Ensembl chr13:43,556,748...43,588,525

G

cyclin-dependent kinase 19

increases expression

afimoxifene results in increased expression of CDK19 mRNA

NCBI chr20:43,770,409...43,910,629
Ensembl chr20:43,770,409...43,910,628

G

cyclin dependent kinase 2

multiple interactions

[afimoxifene co-treated with lapatinib] promotes the reaction [CDKN1B protein binds to and results in decreased activity of [CCNE1 protein binds to CDK2 protein]]; afimoxifene promotes the reaction [CDKN1B protein binds to and results in decreased activity of [CCNE1 protein binds to CDK2 protein]]

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

G

cyclin-dependent kinase 9

decreases response to substance

CDK9 results in decreased susceptibility to afimoxifene

NCBI chr 3:15,996,467...16,001,315
Ensembl chr 3:15,996,468...16,002,410

G

cyclin-dependent kinase inhibitor 1A

multiple interactions
increases expression

afimoxifene inhibits the reaction [Estrogens results in decreased expression of CDKN1A mRNA]
afimoxifene results in increased expression of CDKN1A mRNA

PMID:12154049 PMID:21233418

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 1B

multiple interactions
increases expression

[afimoxifene co-treated with lapatinib] promotes the reaction [CDKN1B protein binds to and results in decreased activity of [CCNE1 protein binds to CDK2 protein]]; [afimoxifene co-treated with lapatinib] results in increased expression of CDKN1B protein; afimoxifene promotes the reaction [CDKN1B protein binds to and results in decreased activity of [CCNE1 protein binds to CDK2 protein]]
afimoxifene results in increased expression of CDKN1B mRNA
afimoxifene results in increased expression of CDKN1B protein

PMID:15665275 PMID:17640349

NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982

G

cyclin-dependent kinase inhibitor 2B

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of CDKN2B mRNA]

NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:104,010,680...104,019,050

G

chromatin licensing and DNA replication factor 1

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of CDT1 mRNA]

NCBI chr19:50,620,713...50,625,659
Ensembl chr19:50,620,713...50,625,659

G

CCAAT/enhancer binding protein delta

increases expression
multiple interactions

afimoxifene results in increased expression of CEBPD mRNA
GPER1 protein affects the reaction [afimoxifene results in increased expression of CEBPD mRNA]

NCBI chr11:84,764,670...84,765,808
Ensembl chr11:84,764,565...84,765,829

G

centromere protein A

decreases expression

afimoxifene results in decreased expression of CENPA mRNA

NCBI chr 6:25,700,142...25,711,767
Ensembl chr 6:25,700,142...25,711,675

G

cingulin

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of CGN mRNA]

NCBI chr 2:182,308,389...182,335,747
Ensembl chr 2:182,308,714...182,334,645

G

cytokine inducible SH2-containing protein

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of CISH mRNA]

NCBI chr 8:107,972,306...107,977,254
Ensembl chr 8:107,972,306...107,977,250

G

creatine kinase B

decreases response to substance

CKB results in decreased susceptibility to afimoxifene

NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315

G

creatine kinase, mitochondrial 1

decreases response to substance

CKMT1B results in decreased susceptibility to afimoxifene

NCBI chr 3:108,329,859...108,335,760
Ensembl chr 3:108,330,705...108,335,758

G

chloride intracellular channel 3

increases expression

afimoxifene results in increased expression of CLIC3 mRNA

NCBI chr 3:8,271,416...8,274,023
Ensembl chr 3:8,272,097...8,274,018

G

CAP-GLY domain containing linker protein 1

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of CLIP1 mRNA]

NCBI chr12:32,910,932...33,017,891
Ensembl chr12:32,910,977...33,017,884

G

CDC-like kinase 4

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of CLK4 mRNA]

NCBI chr10:35,523,382...35,541,387
Ensembl chr10:35,524,755...35,541,352

G

caseinolytic mitochondrial matrix peptidase proteolytic subunit

affects response to substance

CLPP gene affects the susceptibility to afimoxifene

NCBI chr 9:1,831,680...1,837,700
Ensembl chr 9:1,830,311...1,837,693

G

calsyntenin 1

decreases expression

afimoxifene results in decreased expression of CLSTN1 mRNA

NCBI chr 5:160,031,235...160,094,585
Ensembl chr 5:160,031,308...160,094,583

G

CCHC-type zinc finger, nucleic acid binding protein

increases expression

afimoxifene results in increased expression of CNBP mRNA

NCBI chr 4:120,302,768...120,311,694
Ensembl chr 4:120,302,771...120,311,637

G

cannabinoid receptor 1

multiple interactions

afimoxifene inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to CNR1 protein]

NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099

G

cannabinoid receptor 2

multiple interactions

afimoxifene inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to CNR2 protein]; afimoxifene inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) binds to CNR2 protein]

NCBI chr 5:148,125,222...148,151,548
Ensembl chr 5:148,125,604...148,151,548

G

collagen type IV alpha 3 chain

decreases expression

afimoxifene results in decreased expression of COL4A3 mRNA

NCBI chr 9:83,875,849...84,004,955
Ensembl chr 9:83,875,561...84,001,895

G

collagen type IV alpha 6 chain

decreases expression

afimoxifene results in decreased expression of COL4A6 mRNA

NCBI chr X:104,766,463...105,117,499
Ensembl chr X:104,766,957...105,117,500

G

COPI coat complex subunit beta 2

decreases expression

afimoxifene results in decreased expression of COPB2 mRNA

NCBI chr 8:99,161,324...99,183,452
Ensembl chr 8:99,161,350...99,185,197

G

carboxypeptidase M

increases expression

afimoxifene results in increased expression of CPM mRNA

NCBI chr 7:53,225,647...53,286,220
Ensembl chr 7:53,225,696...53,286,220

G

cysteine rich transmembrane BMP regulator 1

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of CRIM1 mRNA]

NCBI chr 6:16,695,864...16,870,264
Ensembl chr 6:16,697,829...16,870,259

G

colony stimulating factor 2

increases expression

afimoxifene results in increased expression of CSF2 mRNA

NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199

G

cysteine and serine rich nuclear protein 1

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of AXUD1 mRNA]

NCBI chr 8:119,704,712...119,717,767
Ensembl chr 8:119,704,713...119,718,183

G

cystatin A

decreases expression

afimoxifene results in decreased expression of CSTA mRNA

NCBI chr11:64,620,483...64,631,488
Ensembl chr11:64,620,483...64,631,488

G

CTD small phosphatase 1

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of CTDSP1 mRNA]

NCBI chr 9:75,973,694...75,979,298
Ensembl chr 9:75,973,962...75,979,297

G

cathepsin D

increases expression

afimoxifene results in increased expression of CTSD mRNA

NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488

G

cathepsin H

increases expression

afimoxifene results in increased expression of CTSH mRNA

NCBI chr 8:90,608,941...90,627,824
Ensembl chr 8:90,608,941...90,627,824

G

CUE domain containing 1

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of CUEDC1 mRNA]

NCBI chr10:72,892,637...72,986,546
Ensembl chr10:72,892,637...72,986,542

G

C-X-C motif chemokine ligand 12

multiple interactions

afimoxifene inhibits the reaction [Estradiol results in increased secretion of CXCL12 protein]; afimoxifene inhibits the reaction [Estrogens results in increased expression of CXCL12 mRNA]

PMID:20549624 PMID:21233418

NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168

G

cytochrome P450, family 19, subfamily a, polypeptide 1

increases expression
increases metabolic processing
multiple interactions

afimoxifene results in increased expression of CYP19A1 mRNA
CYP19A1 protein results in increased metabolism of afimoxifene
[CYP19A1 protein results in increased metabolism of afimoxifene] which results in increased abundance of afimoxifene metabolite

PMID:19549922 PMID:29285606

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
increases expression
increases metabolic processing

3'-methoxy-4'-nitroflavone inhibits the reaction [afimoxifene results in increased expression of CYP1A1 mRNA]; [CYP1A1 protein results in increased metabolism of afimoxifene] which results in increased abundance of afimoxifene metabolite; afimoxifene inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1A1 promoter]]; afimoxifene inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; afimoxifene promotes the reaction [AHR protein binds to CYP1A1 promoter]; alpha-naphthoflavone inhibits the reaction [afimoxifene results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [afimoxifene results in increased expression of CYP1A1 mRNA]

PMID:18493746 PMID:19460354 PMID:19901195 PMID:29285606

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

increases metabolic processing
multiple interactions

CYP1A2 protein results in increased metabolism of afimoxifene
[CYP1A2 protein results in increased metabolism of afimoxifene] which results in increased abundance of afimoxifene metabolite

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

multiple interactions
decreases activity
increases expression

afimoxifene inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1B1 promoter]]
afimoxifene results in decreased activity of CYP1B1 protein
afimoxifene results in increased expression of CYP1B1 mRNA

PMID:12419016 PMID:19460354 PMID:19901195

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 2, subfamily b, polypeptide 3

multiple interactions
increases metabolic processing

[CYP2B6 protein results in increased metabolism of afimoxifene] which results in increased abundance of afimoxifene metabolite

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, family 2, subfamily C, polypeptide 6

increases metabolic processing

CYP2C19 protein results in increased metabolism of afimoxifene

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 2, subfamily c, polypeptide 79

increases metabolic processing
decreases activity

CYP2C8 protein results in increased metabolism of afimoxifene
afimoxifene results in decreased activity of CYP2C8 protein

G

cytochrome P450, family 2, subfamily d, polypeptide 4

multiple interactions
increases metabolic processing

[CYP2D6 protein results in increased metabolism of afimoxifene] which results in increased abundance of afimoxifene metabolite

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases activity
increases metabolic processing
multiple interactions
increases expression
decreases activity

afimoxifene results in increased activity of CYP3A4 protein
CYP3A4 protein results in increased metabolism of afimoxifene
[CYP3A4 protein results in increased metabolism of afimoxifene] which results in increased abundance of afimoxifene metabolite; [CYP3A4 protein results in increased metabolism of Tamoxifen] which results in increased abundance of afimoxifene
afimoxifene results in increased expression of CYP3A4 mRNA
afimoxifene results in decreased activity of CYP3A4 protein

PMID:12419016 PMID:20507880 PMID:29285606

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 9

decreases activity
multiple interactions
increases metabolic processing

afimoxifene results in decreased activity of CYP3A5 protein
[CYP3A5 protein results in increased metabolism of afimoxifene] which results in increased abundance of afimoxifene metabolite

PMID:12419016 PMID:29285606

NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422

G

cytochrome P450, family 4, subfamily f, polypeptide 39

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of CYP4F22 mRNA]

NCBI chr 7:11,426,806...11,505,553
Ensembl chr 7:11,433,371...11,536,181

G

DAB adaptor protein 2

increases expression

afimoxifene results in increased expression of DAB2 mRNA

NCBI chr 2:55,514,692...55,567,476
Ensembl chr 2:55,514,700...55,567,476

G

DNA-damage inducible transcript 3

multiple interactions
increases expression

GPER1 protein affects the reaction [afimoxifene results in increased expression of DDIT3 mRNA]

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

DNA-damage-inducible transcript 4

increases expression
multiple interactions

afimoxifene results in increased expression of DDIT4 mRNA
GPER1 protein affects the reaction [afimoxifene results in increased expression of DDIT4 mRNA]

NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105

G

DEAD-box helicase 10

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of DDX10 mRNA]

NCBI chr 8:53,488,656...53,643,373
Ensembl chr 8:53,488,656...53,643,373

G

DExD-box helicase 21

multiple interactions
decreases expression

afimoxifene inhibits the reaction [Estrogens results in increased expression of DDX21 mRNA]
afimoxifene results in decreased expression of DDX21 mRNA

PMID:16514628 PMID:21233418

NCBI chr20:30,534,319...30,554,513
Ensembl chr20:30,534,319...30,554,543

G

DEAD-box helicase 27

decreases expression

afimoxifene results in decreased expression of DDX27 mRNA

NCBI chr 3:155,744,182...155,763,380
Ensembl chr 3:155,744,150...155,763,372

G

DEAD box helicase 3, Y-linked

decreases expression

afimoxifene results in decreased expression of DDX3Y mRNA

NCBI chr Y:1,115,095...1,135,754
Ensembl chr Y:1,116,309...1,135,706

G

24-dehydrocholesterol reductase

decreases expression

afimoxifene results in decreased expression of DHCR24 mRNA

NCBI chr 5:121,344,552...121,371,124
Ensembl chr 5:121,344,575...121,371,137

G

dehydrogenase/reductase 9

decreases expression

afimoxifene results in decreased expression of DHRS9 mRNA

NCBI chr 3:54,147,834...54,170,052
Ensembl chr 3:54,147,803...54,220,241

G

DEAH-box helicase 33

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of DHX33 mRNA]

NCBI chr10:55,708,102...55,724,618
Ensembl chr10:55,705,756...55,724,567

G

DExH-box helicase 9

decreases expression

afimoxifene results in decreased expression of DHX9 mRNA

NCBI chr13:65,602,322...65,639,098
Ensembl chr13:65,602,323...65,639,069

G

DIX domain containing 1

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of DIXDC1 mRNA]

NCBI chr 8:51,007,835...51,081,191
Ensembl chr 8:51,007,838...51,081,090

G

dyskerin pseudouridine synthase 1

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of DKC1 mRNA]

G

dynein axonemal assembly factor 9

decreases expression

afimoxifene results in decreased expression of DNAAF9 mRNA

NCBI chr 3:117,918,047...118,052,641
Ensembl chr 3:117,921,620...118,052,630

G

dynein, axonemal, heavy chain 2

decreases response to substance

DNAH2 results in decreased susceptibility to afimoxifene

NCBI chr10:54,142,648...54,268,901
Ensembl chr10:54,142,737...54,267,298

G

DnaJ heat shock protein family (Hsp40) member A1

decreases expression

afimoxifene results in decreased expression of DNAJA1 mRNA

NCBI chr 5:55,842,414...55,853,326
Ensembl chr 5:55,842,426...55,853,967

G

DnaJ heat shock protein family (Hsp40) member C12

decreases expression

afimoxifene results in decreased expression of DNAJC12 mRNA

NCBI chr20:25,246,744...25,267,508
Ensembl chr20:25,223,144...25,267,521

G

dopamine receptor D1

increases expression

afimoxifene results in increased expression of DRD1 mRNA

NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002

G

dual specificity phosphatase 1

multiple interactions
increases expression

GPER1 protein affects the reaction [afimoxifene results in increased expression of DUSP1 mRNA]

NCBI chr10:16,680,478...16,683,275

G

dual specificity phosphatase 4

increases expression
multiple interactions

afimoxifene results in increased expression of DUSP4 mRNA
GPER1 protein affects the reaction [afimoxifene results in increased expression of DUSP4 mRNA]

NCBI chr16:57,376,659...57,398,161
Ensembl chr16:57,377,229...57,398,138

G

dual specificity phosphatase 5

increases expression
multiple interactions

afimoxifene results in increased expression of DUSP5 mRNA
GPER1 protein affects the reaction [afimoxifene results in increased expression of DUSP5 mRNA]

NCBI chr 1:252,538,408...252,555,320
Ensembl chr 1:252,538,449...252,551,818

G

dynein light chain LC8-type 1

increases expression

afimoxifene results in increased expression of DYNLL1 mRNA

NCBI chr12:41,312,365...41,316,157
Ensembl chr12:41,312,367...41,314,741

G

E2F transcription factor 4

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of E2F4 mRNA]

NCBI chr19:33,174,396...33,181,806
Ensembl chr19:33,174,410...33,181,806

G

endothelin-converting enzyme 2

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of ECE2 mRNA]

NCBI chr11:80,259,130...80,278,446
Ensembl chr11:80,263,162...80,278,428

G

endothelial differentiation-related factor 1

affects response to substance

EDF1 gene affects the susceptibility to afimoxifene

NCBI chr 3:8,377,058...8,381,363
Ensembl chr 3:8,366,613...8,381,363

G

endothelin 1

increases expression
multiple interactions

afimoxifene results in increased expression of EDN1 mRNA
GPER1 protein affects the reaction [afimoxifene results in increased expression of EDN1 mRNA]

NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885

G

endothelin 2

increases expression
multiple interactions

afimoxifene results in increased expression of EDN2 mRNA
GPER1 protein affects the reaction [afimoxifene results in increased expression of EDN2 mRNA]

NCBI chr 5:133,751,316...133,756,814
Ensembl chr 5:133,751,217...133,756,814

G

estrogen-induced osteoclastogenesis regulator 1

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of EEIG1 mRNA]

NCBI chr 3:15,822,441...15,854,651
Ensembl chr 3:15,823,144...15,854,643

G

ephrin A1

multiple interactions
decreases expression

afimoxifene inhibits the reaction [Estrogens results in decreased expression of EFNA1 mRNA]
afimoxifene results in decreased expression of EFNA1 mRNA

PMID:15072547 PMID:21233418

NCBI chr 2:174,681,676...174,689,061
Ensembl chr 2:174,681,682...174,690,866

G

ephrin B2

increases expression

afimoxifene results in increased expression of EFNB2 mRNA

NCBI chr16:80,783,389...80,827,420
Ensembl chr16:80,783,417...80,824,391

G

epidermal growth factor

multiple interactions

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[afimoxifene co-treated with EGF protein] results in increased expression of CDH1 protein]; [afimoxifene co-treated with EGF protein] results in increased expression of CDH1 mRNA; [afimoxifene co-treated with EGF protein] results in increased expression of CDH1 protein; AG 1879 inhibits the reaction [[afimoxifene co-treated with EGF protein] results in increased expression of CDH1 protein]; fulvestrant inhibits the reaction [[afimoxifene co-treated with EGF protein] results in increased expression of CDH1 protein]

NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064

G

epidermal growth factor receptor

decreases response to substance

EGFR protein results in decreased susceptibility to afimoxifene; EGFR results in decreased susceptibility to afimoxifene

PMID:18351453 PMID:21233418

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

early growth response 1

multiple interactions
increases expression

[BRAF protein co-treated with afimoxifene] results in increased expression of and results in increased activity of EGR1 protein; GPER1 protein affects the reaction [afimoxifene results in increased expression of EGR1 mRNA]

PMID:19153601 PMID:25645941

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

early growth response 3

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of EGR3 mRNA]

NCBI chr15:45,150,335...45,156,052
Ensembl chr15:45,150,567...45,154,627

G

eukaryotic translation initiation factor 2 subunit alpha

decreases expression

afimoxifene results in decreased expression of EIF2S1 mRNA

NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225

G

eukaryotic translation initiation factor 5

decreases expression

afimoxifene results in decreased expression of EIF5 mRNA

NCBI chr 6:130,589,162...130,597,656
Ensembl chr 6:130,589,143...130,597,656

G

E74 like ETS transcription factor 3

increases expression

afimoxifene results in increased expression of ELF3 mRNA

NCBI chr13:46,690,460...46,695,394
Ensembl chr13:46,690,466...46,695,481

G

elongin B

decreases expression

afimoxifene results in decreased expression of ELOB mRNA

NCBI chr10:12,848,830...12,853,897
Ensembl chr10:12,848,827...12,853,635

G

ELOVL fatty acid elongase 2

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of ELOVL2 mRNA]

NCBI chr17:23,544,598...23,584,855
Ensembl chr17:23,544,568...23,584,848

G

ELOVL fatty acid elongase 5

decreases expression

afimoxifene results in decreased expression of ELOVL5 mRNA

NCBI chr 8:78,790,846...78,857,307
Ensembl chr 8:78,790,846...78,857,284

G

ectodermal-neural cortex 1

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of ENC1 mRNA]

NCBI chr 2:28,550,670...28,562,591
Ensembl chr 2:28,550,464...28,562,713

G

enolase 1

decreases response to substance

ENO1 mRNA results in decreased susceptibility to afimoxifene

NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336

G

erythrocyte membrane protein band 4.1 like 4A

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of EPB41L4A mRNA]

NCBI chr18:25,405,461...25,615,392
Ensembl chr18:25,406,057...25,615,149

G

Eph receptor A1

increases expression

afimoxifene results in increased expression of EPHA1 mRNA

NCBI chr 4:71,246,409...71,260,920
Ensembl chr 4:71,246,409...71,260,846

G

EGFR pathway substrate 8, signaling adaptor

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of EPS8 mRNA]

NCBI chr 4:170,388,378...170,486,873
Ensembl chr 4:170,388,378...170,486,873

G

erb-b2 receptor tyrosine kinase 2

increases expression
multiple interactions
decreases response to substance
decreases expression

afimoxifene results in increased expression of ERBB2 mRNA
afimoxifene inhibits the reaction [beta-hexachlorocyclohexane promotes the reaction [ERBB2 protein binds to ERBB3 protein]]; afimoxifene inhibits the reaction [Estrogens results in decreased expression of ERBB2 mRNA]
ERBB2 results in decreased susceptibility to afimoxifene
afimoxifene results in decreased expression of ERBB2 mRNA

PMID:12439862 PMID:15072547 PMID:17640349 PMID:21233418

NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078

G

erb-b2 receptor tyrosine kinase 3

multiple interactions

afimoxifene inhibits the reaction [beta-hexachlorocyclohexane promotes the reaction [ERBB2 protein binds to ERBB3 protein]]

NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525

G

ERBB receptor feedback inhibitor 1

multiple interactions
increases expression

GPER1 protein affects the reaction [afimoxifene results in increased expression of ERRFI1 mRNA]

NCBI chr 5:161,323,981...161,337,289
Ensembl chr 5:161,323,998...161,337,282

G

estrogen receptor 1

increases expression
multiple interactions
decreases activity
affects binding
affects folding
increases activity

afimoxifene results in increased expression of ESR1 protein
afimoxifene binds to and affects the folding of ESR1 protein mutant form; ESR1 protein promotes the reaction [afimoxifene results in increased phosphorylation of and results in increased activity of IGF1R protein]
4-hydroxy-N-desmethyltamoxifen inhibits the reaction [[Tamoxifen co-treated with N-desmethyltamoxifen co-treated with afimoxifene] results in increased stability of ESR1 protein]; [afimoxifene binds to and results in decreased activity of ESR1 protein] which results in decreased susceptibility to Equol; [afimoxifene binds to and results in decreased activity of ESR1 protein] which results in decreased susceptibility to Genistein; [afimoxifene results in decreased susceptibility to Estradiol] which results in decreased expression of ESR1 protein modified form; [afimoxifene results in decreased susceptibility to Glyphosate] which results in increased expression of ESR1 protein modified form; [annonacin co-treated with afimoxifene] results in decreased activity of ESR1 protein; [Lapatinib co-treated with afimoxifene] results in decreased activity of ESR1 protein; [methylselenic acid co-treated with afimoxifene] results in decreased expression of ESR1 mRNA; [methylselenic acid co-treated with afimoxifene] results in decreased expression of ESR1 protein; [Tamoxifen co-treated with N-desmethyltamoxifen co-treated with afimoxifene] results in increased stability of ESR1 protein; afimoxifene binds to and affects the activity of ESR1 protein; afimoxifene binds to and affects the folding of ESR1 protein; afimoxifene binds to and affects the folding of ESR1 protein mutant form; afimoxifene binds to and results in decreased activity of ESR1 protein; afimoxifene binds to and results in increased activity of ESR1 protein; afimoxifene inhibits the reaction [16 alpha-iodoestradiol binds to ESR1 protein]; afimoxifene inhibits the reaction [[Arsenic Trioxide results in increased expression of ESR1 protein] which results in increased expression of GREB1 mRNA]; afimoxifene inhibits the reaction [[Arsenic Trioxide results in increased expression of ESR1 protein] which results in increased expression of TFF1 mRNA]; afimoxifene inhibits the reaction [[Chlorpyrifos co-treated with Estradiol] results in increased activity of ESR1 protein]; afimoxifene inhibits the reaction [[Estradiol co-treated with ESR1 protein] results in increased activity of NCOA2 protein]; afimoxifene inhibits the reaction [[fenarimol co-treated with Estradiol] results in increased activity of ESR1 protein]; afimoxifene inhibits the reaction [bisphenol A results in increased activity of ESR1 protein]; afimoxifene inhibits the reaction [ESR1 protein binds to STUB1 protein]; afimoxifene inhibits the reaction [Estradiol binds to ESR1 protein]; afimoxifene inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; afimoxifene inhibits the reaction [Estradiol results in increased expression of ESR1 protein]; afimoxifene inhibits the reaction [Estradiol results in increased phosphorylation of ESR1 protein]; afimoxifene inhibits the reaction [fenarimol results in increased activity of ESR1 protein]; afimoxifene inhibits the reaction [Glyphosate results in increased expression of ESR1 protein]; afimoxifene inhibits the reaction [Hexestrol binds to and results in increased activity of ESR1 protein]; afimoxifene inhibits the reaction [nonylphenol results in increased activity of ESR1 protein]; afimoxifene inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1A1 promoter]]; afimoxifene inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1B1 promoter]]; afimoxifene promotes the reaction [ESR1 protein alternative form binds to ESR1 protein alternative form]; afimoxifene promotes the reaction [ESR1 protein binds to CDH1 promoter]; afimoxifene promotes the reaction [ESR1 protein binds to TFF1 promoter]; afimoxifene results in increased activity of and affects the localization of ESR1 protein; ARID5A protein inhibits the reaction [afimoxifene results in increased activity of ESR1 protein]; ESR1 protein promotes the reaction [afimoxifene results in increased expression of SERPINB9 mRNA]; Plicamycin inhibits the reaction [afimoxifene promotes the reaction [ESR1 protein binds to CDH1 promoter]]
afimoxifene results in decreased activity of ESR1 protein
afimoxifene binds to ESR1 protein
afimoxifene affects the folding of ESR1 protein
[afimoxifene binds to ESR1 protein] which binds to TFF1 protein; afimoxifene binds to ESR1 protein

PMID:9048584 PMID:9751507 PMID:9846162 PMID:10397250 PMID:10614829 More...

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

affects expression
increases response to substance
multiple interactions
affects binding
increases activity

afimoxifene affects the expression of ESR2 protein
ESR2 protein results in increased susceptibility to afimoxifene
afimoxifene inhibits the reaction [16 alpha-iodoestradiol binds to ESR2 protein]; afimoxifene inhibits the reaction [Estradiol binds to ESR2 protein alternative form]
1,1-bis(4-hydroxyphenyl)-2,2-dichloroethylene affects the reaction [afimoxifene binds to ESR2 protein]; 4,4'-hexafluorisopropylidene diphenol affects the reaction [afimoxifene binds to ESR2 protein]; afimoxifene binds to and results in decreased activity of ESR2 protein; afimoxifene inhibits the reaction [Estradiol binds to ESR2 protein]; afimoxifene inhibits the reaction [Estradiol results in increased activity of ESR2 protein]; afimoxifene inhibits the reaction [methoxyacetic acid promotes the reaction [Estradiol results in increased activity of ESR2 protein]]; bisphenol A inhibits the reaction [afimoxifene binds to ESR2 protein]; ESR2 protein inhibits the reaction [afimoxifene results in increased expression of FARP1 mRNA]; ESR2 protein inhibits the reaction [afimoxifene results in increased expression of IER3 mRNA]; ESR2 protein inhibits the reaction [afimoxifene results in increased expression of RAB30 mRNA]; ESR2 protein inhibits the reaction [afimoxifene results in increased expression of SOCS1 mRNA]
4-hydroxytamoxifen binds to Esr2 protein
afimoxifene results in increased activity of ESR2 protein

CTD
RGD

PMID:9048584 PMID:9492041 PMID:9751507 PMID:15103026 PMID:15537743 More...

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

estrogen related receptor, alpha

multiple interactions
affects binding

afimoxifene binds to and results in decreased activity of [ESRRG protein binds to ESRRA protein]
afimoxifene binds to ESRRA protein mutant form

PMID:11447273 PMID:14751226

NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268

G

estrogen-related receptor gamma

multiple interactions
decreases activity
affects binding

2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane inhibits the reaction [afimoxifene binds to and results in decreased activity of ESRRG protein]; 4-isopropylphenol inhibits the reaction [afimoxifene binds to and results in decreased activity of ESRRG protein]; 5,6,7,8-tetrahydro-2-naphthol inhibits the reaction [afimoxifene binds to and results in decreased activity of ESRRG protein]; afimoxifene binds to and affects the activity of ESRRG protein; afimoxifene binds to and results in decreased activity of [ESRRG protein binds to ESRRA protein]; afimoxifene binds to and results in decreased activity of ESRRG protein; afimoxifene inhibits the reaction [ESRRG protein binds to NCOA1 protein]; afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]; afimoxifene inhibits the reaction [PPARGC1A protein binds to ESRRG protein]; benzylparaben inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]; bisphenol A inhibits the reaction [afimoxifene binds to and results in decreased activity of ESRRG protein]; bisphenol A inhibits the reaction [afimoxifene binds to ESRRG protein]; bisphenol A inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]; bisphenol A inhibits the reaction [afimoxifene results in decreased activity of ESRRG protein]; butylparaben inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]; chlorocresol inhibits the reaction [afimoxifene binds to ESRRG protein]; ethyl salicylate inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]; ethyl-p-hydroxybenzoate inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]; methyl salicylate inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]; methylparaben inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]; N'-((1E)-(4-(diethylamino)phenyl)methylene)-4-hydroxybenzohydrazide inhibits the reaction [afimoxifene results in decreased activity of ESRRG protein]; propylparaben inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]
afimoxifene binds to and results in decreased activity of ESRRG protein; afimoxifene inhibits the reaction [bisphenol A binds to and results in increased activity of ESRRG protein]

PMID:11447273 PMID:14751226 PMID:15149736 PMID:15161930 PMID:16889744 More...

NCBI chr13:99,167,656...99,788,016
Ensembl chr13:99,564,669...99,783,397

G

ethanolamine kinase 1

decreases response to substance
increases expression

ETNK1 results in decreased susceptibility to afimoxifene
afimoxifene results in increased expression of ETNK1 mRNA

PMID:16849584 PMID:21233418

NCBI chr 4:176,126,056...176,170,325
Ensembl chr 4:176,126,180...176,193,770

G

exosome component 2

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of EXOSC2 mRNA]

NCBI chr 3:14,962,930...14,973,645
Ensembl chr 3:14,962,917...14,973,575

G

fatty acid 2-hydroxylase

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of FA2H mRNA]

NCBI chr19:39,312,904...39,364,153
Ensembl chr19:39,312,906...39,364,153

G

Fas apoptotic inhibitory molecule 2

decreases expression

afimoxifene results in decreased expression of FAIM2 mRNA

NCBI chr 7:130,632,368...130,659,353
Ensembl chr 7:130,633,348...130,659,168

G

family with sequence similarity 107, member B

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of FAM107B mRNA]

NCBI chr17:74,478,608...74,685,027
Ensembl chr17:74,478,608...74,684,989

G

family with sequence similarity 110, member B

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of FAM110B mRNA]

NCBI chr 5:18,789,362...18,929,647
Ensembl chr 5:18,789,389...18,929,828

G

family with sequence similarity 110, member C

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of FAM110C mRNA]

NCBI chr 6:47,638,466...47,644,723
Ensembl chr 6:47,638,276...47,644,634

G

family with sequence similarity 204, member A

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of FAM204A mRNA]

NCBI chr 1:259,328,551...259,366,726
Ensembl chr 1:259,337,709...259,367,077

G

FAM20C, golgi associated secretory pathway kinase

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of FAM20C mRNA]

NCBI chr12:15,826,864...15,885,423
Ensembl chr12:15,826,871...15,884,543

G

family with sequence similarity 43, member A

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of FAM43A mRNA]

NCBI chr11:70,128,253...70,131,401
Ensembl chr11:70,128,253...70,131,401

G

family with sequence similarity 83, member B

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of FAM83B mRNA]

NCBI chr 8:77,287,351...77,363,795
Ensembl chr 8:77,287,351...77,363,795

G

FERM, ARH/RhoGEF and pleckstrin domain protein 1

increases expression
multiple interactions

afimoxifene results in increased expression of FARP1 mRNA
ESR2 protein inhibits the reaction [afimoxifene results in increased expression of FARP1 mRNA]; Estradiol inhibits the reaction [afimoxifene results in increased expression of FARP1 mRNA]; Fulvestrant inhibits the reaction [afimoxifene results in increased expression of FARP1 mRNA]

NCBI chr15:98,124,304...98,363,299
Ensembl chr15:98,182,329...98,363,299

G

FAT atypical cadherin 1

decreases expression

afimoxifene results in decreased expression of FAT1 mRNA

NCBI chr16:47,177,253...47,296,261
Ensembl chr16:47,177,248...47,296,107

G

F-box and leucine-rich repeat protein 18

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of FBXL18 mRNA]

NCBI chr12:11,674,538...11,701,317
Ensembl chr12:11,676,115...11,699,181

G

filamin A

increases expression

afimoxifene results in increased expression of FLNA mRNA

NCBI chr X:152,007,758...152,034,266
Ensembl chr X:152,007,758...152,031,052

G

filamin C

decreases expression

afimoxifene results in decreased expression of FLNC mRNA

NCBI chr 4:58,034,088...58,061,882
Ensembl chr 4:58,034,189...58,061,844

G

Fms related receptor tyrosine kinase 1

decreases secretion

afimoxifene results in decreased secretion of FLT1 protein

NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626

G

fibronectin 1

decreases expression

afimoxifene results in decreased expression of FN1 mRNA

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [afimoxifene results in increased expression of FOS mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [afimoxifene results in increased expression of FOS protein]; GPER1 protein affects the reaction [afimoxifene results in increased expression of FOS mRNA]; RTKI cpd inhibits the reaction [afimoxifene results in increased expression of FOS mRNA]; RTKI cpd inhibits the reaction [afimoxifene results in increased expression of FOS protein]
afimoxifene results in increased expression of FOS mRNA; afimoxifene results in increased expression of FOS protein

PMID:15072547 PMID:19153601 PMID:19901195 PMID:19935718

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

FosB proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression

GPER1 protein affects the reaction [afimoxifene results in increased expression of FOSB mRNA]

NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465

G

forkhead box P4

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of FOXP4 mRNA]

NCBI chr 9:13,058,506...13,115,406
Ensembl chr 9:13,058,476...13,114,879

G

FRAT regulator of WNT signaling pathway 1

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of FRAT1 mRNA]

NCBI chr 1:240,638,309...240,640,857
Ensembl chr 1:240,638,296...240,640,945

G

fyn-related Src family tyrosine kinase

increases expression
decreases response to substance

afimoxifene results in increased expression of FRK mRNA
FRK results in decreased susceptibility to afimoxifene

PMID:19901195 PMID:21233418

NCBI chr20:38,265,416...38,371,038
Ensembl chr20:38,265,280...38,371,114

G

FERM domain containing 6

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of FRMD6 mRNA]

NCBI chr 6:89,345,983...89,419,579
Ensembl chr 6:89,346,035...89,419,579

G

fucosyltransferase 8

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of FUT8 mRNA]

NCBI chr 6:95,949,246...96,176,677
Ensembl chr 6:95,949,991...96,176,677

G

Friend virus susceptibility 1

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of C19ORF48P mRNA]

NCBI chr 1:94,730,839...94,736,791
Ensembl chr 1:94,730,606...94,737,594

G

forty-two-three domain containing 1

decreases expression

afimoxifene results in decreased expression of FYTTD1 mRNA

NCBI chr11:67,877,967...67,907,500
Ensembl chr11:67,877,967...67,907,511

G

GRB2-associated binding protein 2

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of GAB2 mRNA]

NCBI chr 1:151,429,844...151,625,708
Ensembl chr 1:151,429,695...151,625,031

G

polypeptide N-acetylgalactosaminyltransferase 6

decreases expression

afimoxifene results in decreased expression of GALNT6 mRNA

NCBI chr 7:131,789,836...131,828,077
Ensembl chr 7:131,789,839...131,819,661

G

1,4-alpha-glucan branching enzyme 1

increases expression

afimoxifene results in increased expression of GBE1 mRNA

NCBI chr11:8,734,806...9,000,226
Ensembl chr11:8,734,820...9,000,210

G

guanylate binding protein family member 6

decreases expression

afimoxifene results in decreased expression of GBP9 mRNA

NCBI chr14:4,730,286...4,756,508
Ensembl chr14:4,730,453...4,839,062
Ensembl chr14:4,730,453...4,839,062

G

golgi associated, gamma adaptin ear containing, ARF binding protein 2

increases expression

afimoxifene results in increased expression of GGA2 mRNA

NCBI chr 1:176,552,046...176,585,332
Ensembl chr 1:176,552,046...176,585,361

G

growth hormone 1

multiple interactions

afimoxifene promotes the reaction [GH1 protein results in increased phosphorylation of JAK2 protein]

NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078

G

GINS complex subunit 3

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of GINS3 mRNA]

NCBI chr19:9,420,085...9,428,621
Ensembl chr19:9,420,086...9,428,687

G

gap junction protein, alpha 1

decreases expression

afimoxifene results in decreased expression of GJA1 protein

NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582

G

glucocorticoid induced 1

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of GLCCI1 mRNA]

NCBI chr 4:36,307,956...36,635,614
Ensembl chr 4:36,307,903...36,635,612

G

golgin A5

decreases expression

afimoxifene results in decreased expression of GOLGA5 mRNA

NCBI chr 6:121,612,389...121,640,552
Ensembl chr 6:121,612,529...121,640,413

G

G protein-coupled estrogen receptor 1

multiple interactions
affects response to substance
increases activity

GPER1 protein affects the reaction [afimoxifene results in increased cleavage of CCNE1 protein]; GPER1 protein affects the reaction [afimoxifene results in increased expression of ATF3 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of BHLHE40 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of CCN1 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of CCN2 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of CEBPD mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of DDIT3 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of DDIT4 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of DUSP1 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of DUSP4 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of DUSP5 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of EDN1 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of EDN2 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of EGR1 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of ERRFI1 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of FOS mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of FOSB mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of IER2 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of ITPRIP mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of JUN mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of MT1A mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of MT1F mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of MT1G mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of MT1X mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of MT2A mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of NFKBIA mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of NR4A2 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of PPP1R15A mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of PTGER4 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of RASD1 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of RGS16 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of RND1 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of TNF mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of TNFAIP3 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of TUFT1 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of ZFP36 mRNA]
GPER1 protein affects the susceptibility to afimoxifene
afimoxifene results in increased activity of GPER1 protein

PMID:19153601 PMID:23624423

NCBI chr12:15,217,217...15,222,679
Ensembl chr12:15,217,442...15,221,889

G

G protein-coupled receptor 157

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of GPR157 mRNA]

NCBI chr 5:160,550,703...160,566,432
Ensembl chr 5:160,550,713...160,566,432

G

G protein-coupled receptor, class C, group 5, member D

affects response to substance

GPRC5D gene affects the susceptibility to afimoxifene

NCBI chr 4:167,943,523...167,955,616
Ensembl chr 4:167,943,523...167,955,616

G

G protein pathway suppressor 2

multiple interactions

afimoxifene promotes the reaction [GPS2 protein binds to TFF1 promoter]

NCBI chr10:54,637,360...54,640,542
Ensembl chr10:54,637,455...54,640,650

G

growth factor receptor bound protein 7

decreases response to substance

GRB7 protein results in decreased susceptibility to afimoxifene

NCBI chr10:83,443,387...83,453,057
Ensembl chr10:83,444,004...83,453,052

G

growth regulating estrogen receptor binding 1

multiple interactions

afimoxifene inhibits the reaction [[Arsenic Trioxide results in increased expression of ESR1 protein] which results in increased expression of GREB1 mRNA]; afimoxifene inhibits the reaction [Arsenic Trioxide results in increased expression of GREB1 mRNA]; afimoxifene inhibits the reaction [Estradiol results in increased expression of GREB1 mRNA]; afimoxifene inhibits the reaction [Estrogens results in increased expression of GREB1 mRNA]

PMID:21233418 PMID:22558281 PMID:26879975 PMID:33769548

NCBI chr 6:39,440,522...39,562,364
Ensembl chr 6:39,440,504...39,581,633

G

glutamate metabotropic receptor 4

increases expression

afimoxifene results in increased expression of GRM4 mRNA

NCBI chr20:5,484,172...5,572,821
Ensembl chr20:5,481,124...5,572,821

G

histone deacetylase 3

multiple interactions

afimoxifene promotes the reaction [HDAC3 protein binds to TFF1 promoter]

NCBI chr18:29,770,637...29,789,850
Ensembl chr18:29,770,636...29,793,856

G

heparin binding growth factor

increases expression

afimoxifene results in increased expression of HDGF mRNA

NCBI chr 2:173,370,147...173,379,756
Ensembl chr 2:173,370,465...173,379,747

G

high mobility group box 1

decreases expression

afimoxifene results in decreased expression of HMGB1 mRNA

NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565

G

heterogeneous nuclear ribonucleoprotein A2/B1

decreases expression

afimoxifene results in decreased expression of HNRNPA2B1 mRNA

NCBI chr 4:80,534,659...80,545,297
Ensembl chr 4:80,534,651...80,545,249

G

heterogeneous nuclear ribonucleoprotein A/B

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of HNRNPAB mRNA]

NCBI chr10:35,857,040...35,862,935
Ensembl chr10:35,857,041...35,863,344

G

heterogeneous nuclear ribonucleoprotein H1

decreases expression

afimoxifene results in decreased expression of HNRNPH1 mRNA

NCBI chr10:34,692,868...34,702,849
Ensembl chr10:34,693,555...34,702,846

G

heterogeneous nuclear ribonucleoprotein U

decreases expression

afimoxifene results in decreased expression of HNRNPU mRNA

NCBI chr13:90,069,058...90,086,905
Ensembl chr13:90,074,181...90,086,588

G

homeobox C13

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of HOXC13 mRNA]

NCBI chr 7:134,058,640...134,065,479
Ensembl chr 7:134,058,640...134,064,800

G

hydroxysteroid (17-beta) dehydrogenase 11

increases expression

afimoxifene results in increased expression of HSD17B11 mRNA

NCBI chr14:5,693,304...5,743,157
Ensembl chr14:5,711,964...5,743,161

G

heat shock transcription factor 1

multiple interactions

afimoxifene inhibits the reaction [Estradiol results in increased phosphorylation of HSF1 protein]

NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011

G

heat shock protein 90 alpha family class B member 1

decreases expression

afimoxifene results in decreased expression of HSP90AB1 mRNA

NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488

G

heat shock protein 90 beta family member 1

decreases expression

afimoxifene results in decreased expression of HSP90B1 mRNA

NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788

G

heat shock protein family A (Hsp70) member 2

decreases expression

afimoxifene results in decreased expression of HSPA2 mRNA

NCBI chr 6:95,128,504...95,131,281
Ensembl chr 6:95,128,350...95,131,287

G

heat shock protein family A (Hsp70) member 4

decreases expression

afimoxifene results in decreased expression of HSPA4 mRNA

NCBI chr10:37,408,025...37,449,080
Ensembl chr10:37,408,025...37,449,001

G

heat shock protein family A (Hsp70) member 8

decreases expression

afimoxifene results in decreased expression of HSPA8 mRNA

NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259

G

heat shock protein family B (small) member 1

increases expression

afimoxifene results in increased expression of HSPB1 mRNA

NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743

G

heat shock protein family B (small) member 8

multiple interactions
decreases response to substance

afimoxifene inhibits the reaction [Estrogens results in increased expression of HSPB8 mRNA]
HSPB8 results in decreased susceptibility to afimoxifene

NCBI chr12:40,176,405...40,205,002
Ensembl chr12:40,176,532...40,191,185

G

heat shock protein family D (Hsp60) member 1

decreases expression

afimoxifene results in decreased expression of HSPD1 mRNA

NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662

G

inhibitor of DNA binding 3

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of ID3 mRNA]

NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349

G

immediate early response 2

multiple interactions
increases expression

GPER1 protein affects the reaction [afimoxifene results in increased expression of IER2 mRNA]

NCBI chr19:23,494,551...23,496,075
Ensembl chr19:23,494,184...23,499,211

G

immediate early response 3

multiple interactions
increases expression

[afimoxifene co-treated with Cycloheximide] results in increased expression of IER3 mRNA; Dactinomycin inhibits the reaction [afimoxifene results in increased expression of IER3 mRNA]; ESR2 protein inhibits the reaction [afimoxifene results in increased expression of IER3 mRNA]; Estradiol inhibits the reaction [afimoxifene results in increased expression of IER3 mRNA]; Fulvestrant inhibits the reaction [afimoxifene results in increased expression of IER3 mRNA]
afimoxifene results in increased expression of IER3 mRNA; afimoxifene results in increased expression of IER3 protein

NCBI chr20:2,928,378...2,929,582
Ensembl chr20:2,928,378...2,929,583

G

interferon-related developmental regulator 1

decreases expression

afimoxifene results in decreased expression of IFRD1 mRNA

NCBI chr 6:57,269,395...57,317,833
Ensembl chr 6:57,269,384...57,288,990

G

insulin-like growth factor 1

increases expression

afimoxifene results in increased expression of IGF1 mRNA

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

insulin-like growth factor 1 receptor

multiple interactions
increases expression
decreases response to substance

afimoxifene inhibits the reaction [Estrogens results in increased expression of IGF1R mRNA]
afimoxifene results in increased expression of IGF1R mRNA
IGF1R results in decreased susceptibility to afimoxifene
afimoxifene results in increased phosphorylation of and results in increased activity of IGF1R protein; ESR1 protein promotes the reaction [afimoxifene results in increased phosphorylation of and results in increased activity of IGF1R protein]

PMID:10965916 PMID:17640349 PMID:21233418

NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777

G

insulin-like growth factor binding protein 1

increases expression

afimoxifene results in increased expression of IGFBP1 mRNA

NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482

G

insulin-like growth factor binding protein 3

increases expression

afimoxifene results in increased expression of IGFBP3 mRNA

NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083

G

insulin-like growth factor binding protein 4

multiple interactions
increases expression

afimoxifene inhibits the reaction [Estrogens results in increased expression of IGFBP4 mRNA]
afimoxifene results in increased expression of IGFBP4 mRNA

PMID:15072547 PMID:19901195 PMID:21233418

NCBI chr10:83,995,253...84,007,272
Ensembl chr10:83,989,591...84,007,225

G

immunoglobulin superfamily, member 3

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of IGSF3 mRNA]

NCBI chr 2:188,811,394...188,899,645
Ensembl chr 2:188,811,380...188,899,645

G

interleukin 1 alpha

decreases expression

afimoxifene results in decreased expression of IL1A mRNA

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 receptor type 1

multiple interactions

[afimoxifene co-treated with 4-hydroxycyclophosphamide] affects the expression of IL1R1 mRNA

NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937

G

interleukin 2 receptor subunit gamma

multiple interactions

[afimoxifene co-treated with 4-hydroxycyclophosphamide] affects the expression of IL2RG mRNA

NCBI chr X:66,395,330...66,399,026
Ensembl chr X:66,392,542...66,399,823

G

interleukin 7 receptor

increases expression

afimoxifene results in increased expression of IL7R mRNA

NCBI chr 2:58,452,393...58,477,757
Ensembl chr 2:58,454,217...58,477,757

G

inflammation and lipid regulator with UBA-like and NBR1-like domains

decreases expression

afimoxifene results in decreased expression of ILRUN mRNA

NCBI chr20:5,809,931...5,876,197
Ensembl chr20:5,809,936...5,876,012

G

inhibitor of growth family, member 5

affects response to substance

ING5 gene affects the susceptibility to afimoxifene

NCBI chr 9:94,326,549...94,343,392
Ensembl chr 9:94,326,548...94,344,220

G

insulin induced gene 2

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of INSIG2 mRNA]

NCBI chr13:32,472,390...32,500,139
Ensembl chr13:32,473,742...32,494,923

G

IQ motif containing GTPase activating protein 1

decreases expression

afimoxifene results in decreased expression of IQGAP1 mRNA

NCBI chr 1:134,679,581...134,769,776
Ensembl chr 1:134,679,586...134,769,755

G

interferon regulatory factor 2

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of IRF2 mRNA]

NCBI chr16:45,439,215...45,550,054
Ensembl chr16:45,439,225...45,550,024

G

interferon regulatory factor 2 binding protein-like

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of IRF2BPL mRNA]

NCBI chr 6:106,527,179...106,531,294
Ensembl chr 6:106,528,053...106,530,401

G

insulin receptor substrate 1

increases expression

afimoxifene results in increased expression of IRS1 mRNA

NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122

G

interferon stimulated exonuclease gene 20-like 2

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of ISG20L2 mRNA]

NCBI chr 2:173,396,780...173,407,102
Ensembl chr 2:173,396,780...173,406,614

G

inositol-tetrakisphosphate 1-kinase

decreases response to substance

ITPK1 results in decreased susceptibility to afimoxifene

NCBI chr 6:121,710,750...121,844,501
Ensembl chr 6:121,710,755...121,844,107

G

inositol 1,4,5-trisphosphate receptor interacting protein

multiple interactions
increases expression

GPER1 protein affects the reaction [afimoxifene results in increased expression of ITPRIP mRNA]

NCBI chr 1:246,762,804...246,786,379
Ensembl chr 1:246,762,472...246,786,408

G

Janus kinase 2

multiple interactions

afimoxifene promotes the reaction [GH1 protein results in increased phosphorylation of JAK2 protein]

NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189

G

Janus kinase 3

decreases response to substance

JAK3 results in decreased susceptibility to afimoxifene

NCBI chr16:18,386,330...18,398,542
Ensembl chr16:18,386,405...18,398,536

G

Jun proto-oncogene, AP-1 transcription factor subunit

increases phosphorylation
multiple interactions
increases expression

afimoxifene results in increased phosphorylation of JUN protein
Acetylcysteine inhibits the reaction [afimoxifene results in increased phosphorylation of JUN protein]; GPER1 protein affects the reaction [afimoxifene results in increased expression of JUN mRNA]

PMID:19153601 PMID:19935718

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

kelch repeat and BTB domain containing 2

increases expression

afimoxifene results in increased expression of KBTBD2 mRNA

NCBI chr 4:86,027,947...86,050,266
Ensembl chr 4:86,027,947...86,050,211

G

potassium calcium-activated channel subfamily N member 4

decreases expression

afimoxifene results in decreased expression of KCNN4 mRNA

NCBI chr 1:79,956,380...79,974,354
Ensembl chr 1:79,959,322...79,974,340

G

kinase insert domain receptor

multiple interactions

afimoxifene inhibits the reaction [Estradiol results in increased expression of KDR protein]; afimoxifene inhibits the reaction [Glyphosate results in increased expression of KDR protein]

NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018

G

ketohexokinase

decreases response to substance

KHK results in decreased susceptibility to afimoxifene

NCBI chr 6:25,445,298...25,455,834
Ensembl chr 6:25,445,300...25,455,717

G

kinesin family member 20A

decreases expression

afimoxifene results in decreased expression of KIF20A mRNA

NCBI chr18:26,230,294...26,238,780
Ensembl chr18:26,230,230...26,238,780

G

kinesin light chain 1

increases expression

afimoxifene results in increased expression of KLC1 mRNA

NCBI chr 6:130,823,416...130,866,729
Ensembl chr 6:130,823,419...130,867,031

G

KLF transcription factor 10

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of KLF10 mRNA]

NCBI chr 7:69,467,658...69,473,726
Ensembl chr 7:69,465,619...69,473,994

G

kallikrein-related peptidase 15

multiple interactions

[afimoxifene co-treated with 4-hydroxycyclophosphamide] affects the expression of KLK15 mRNA

NCBI chr 1:94,699,422...94,706,626
Ensembl chr 1:94,703,158...94,706,329
Ensembl chr 1:94,703,158...94,706,329

G

karyopherin subunit alpha 2

decreases expression

afimoxifene results in decreased expression of KPNA2 mRNA

NCBI chr10:91,933,951...91,946,115
Ensembl chr10:91,933,951...91,946,150

G

karyopherin subunit beta 1

decreases expression

afimoxifene results in decreased expression of KPNB1 mRNA

NCBI chr10:82,145,662...82,174,437
Ensembl chr10:82,145,420...82,174,605

G

KRAS proto-oncogene, GTPase

affects response to substance

KRAS gene affects the susceptibility to afimoxifene

NCBI chr 4:178,185,418...178,218,484

G

keratin 13

multiple interactions
increases expression

[afimoxifene co-treated with Cycloheximide] results in increased expression of KRT13 mRNA; Estradiol inhibits the reaction [afimoxifene results in increased expression of KRT13 mRNA]; Fulvestrant inhibits the reaction [afimoxifene results in increased expression of KRT13 mRNA]

NCBI chr10:85,051,887...85,056,099
Ensembl chr10:85,051,889...85,056,084

G

keratin 19

decreases expression

afimoxifene results in decreased expression of KRT19 mRNA

NCBI chr10:85,075,835...85,080,552
Ensembl chr10:85,066,802...85,171,799

G

LIM and SH3 protein 1

increases expression

afimoxifene results in increased expression of LASP1 mRNA

NCBI chr10:82,795,177...82,835,659
Ensembl chr10:82,795,137...82,943,292

G

LCK proto-oncogene, Src family tyrosine kinase

decreases expression

afimoxifene results in decreased expression of LCK mRNA

NCBI chr 5:141,888,318...141,916,945
Ensembl chr 5:141,888,326...141,903,794

G

ligand of numb-protein X 1

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of LNX1 mRNA]

NCBI chr14:33,514,429...33,617,086
Ensembl chr14:33,514,436...33,617,086

G

leucine rich repeats and calponin homology domain containing 3

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of LRCH3 mRNA]

NCBI chr11:67,772,499...67,872,269
Ensembl chr11:67,772,506...67,872,264

G

LDL receptor related protein 2

decreases expression

afimoxifene results in decreased expression of LRP2 mRNA

NCBI chr 3:54,189,305...54,346,769
Ensembl chr 3:54,189,308...54,346,708

G

LRR binding FLII interacting protein 2

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of LRRFIP2 mRNA]

NCBI chr 8:111,091,453...111,193,947
Ensembl chr 8:111,091,503...111,193,255

G

lanosterol synthase

increases expression

afimoxifene results in increased expression of LSS mRNA

NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762

G

latent transforming growth factor beta binding protein 1

increases expression

afimoxifene results in increased expression of LTBP1 mRNA

NCBI chr 6:20,029,629...20,425,339
Ensembl chr 6:20,029,629...20,425,349

G

lactotransferrin

increases expression

afimoxifene results in increased expression of LTF protein

NCBI chr 8:110,999,948...111,022,795
Ensembl chr 8:110,999,948...111,022,795

G

LYN proto-oncogene, Src family tyrosine kinase

decreases response to substance

LYN results in decreased susceptibility to afimoxifene

NCBI chr 5:16,639,512...16,755,501
Ensembl chr 5:16,639,466...16,756,868

G

Ly6/Plaur domain containing 3

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of LYPD3 mRNA]

NCBI chr 1:80,226,449...80,230,901
Ensembl chr 1:80,226,449...80,230,901

G

mal, T-cell differentiation protein-like

increases expression
decreases expression

afimoxifene results in increased expression of MALL mRNA
afimoxifene results in decreased expression of MALL mRNA

PMID:19698761 PMID:19901195

NCBI chr 3:114,927,897...114,950,840
Ensembl chr 3:114,927,897...114,950,785

G

mannosidase, endo-alpha-like

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of MANEAL mRNA]

NCBI chr 5:137,115,154...137,122,299
Ensembl chr 5:137,115,632...137,122,353

G

mitogen activated protein kinase kinase 1

increases expression

afimoxifene results in increased expression of MAP2K1 mRNA

NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147

G

mitogen activated protein kinase kinase 2

decreases response to substance

MAP2K2 results in decreased susceptibility to afimoxifene

NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243

G

mitogen activated protein kinase kinase 3

decreases response to substance

MAP2K3 results in decreased susceptibility to afimoxifene

NCBI chr10:45,608,145...45,629,492
Ensembl chr10:45,607,163...45,629,492

G

mitogen activated protein kinase kinase 4

decreases response to substance

MAP2K4 results in decreased susceptibility to afimoxifene

NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993

G

mitogen activated protein kinase kinase 5

decreases response to substance

MAP2K5 results in decreased susceptibility to afimoxifene

NCBI chr 8:63,625,220...63,852,090
Ensembl chr 8:63,625,221...63,851,983

G

mitogen-activated protein kinase kinase 6

decreases response to substance

MAP2K6 results in decreased susceptibility to afimoxifene

NCBI chr10:95,373,304...95,490,406
Ensembl chr10:95,373,204...95,488,293

G

mitogen activated protein kinase kinase 7

decreases response to substance

MAP2K7 results in decreased susceptibility to afimoxifene

NCBI chr12:2,591,312...2,600,534
Ensembl chr12:2,591,219...2,604,222

G

mitogen-activated protein kinase kinase kinase 8

decreases response to substance

MAP3K8 results in decreased susceptibility to afimoxifene

NCBI chr17:53,382,908...53,403,216
Ensembl chr17:53,383,131...53,403,216

G

mitogen activated protein kinase 1

decreases response to substance
increases phosphorylation
multiple interactions

MAPK1 results in decreased susceptibility to afimoxifene
afimoxifene results in increased phosphorylation of MAPK1 protein
[BRAF protein co-treated with afimoxifene] results in increased phosphorylation of MAPK1 protein; afimoxifene inhibits the reaction [Estradiol results in increased phosphorylation of MAPK1 protein]; afimoxifene inhibits the reaction [Glyphosate results in increased phosphorylation of MAPK1 protein]
afimoxifene inhibits the reaction [[bisphenol A co-treated with Glutamic Acid] results in increased phosphorylation of MAPK1 protein]

PMID:19549922 PMID:21233418 PMID:23624423 PMID:25645941 PMID:29890199 More...

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen-activated protein kinase 11

decreases response to substance

MAPK11 results in decreased susceptibility to afimoxifene

NCBI chr 7:120,218,471...120,225,488
Ensembl chr 7:120,218,478...120,225,395

G

mitogen-activated protein kinase 12

decreases response to substance

MAPK12 results in decreased susceptibility to afimoxifene

NCBI chr 7:120,206,005...120,216,711
Ensembl chr 7:120,206,271...120,216,664

G

mitogen activated protein kinase 13

decreases response to substance

MAPK13 results in decreased susceptibility to afimoxifene

NCBI chr20:6,835,277...6,845,500
Ensembl chr20:6,835,320...6,844,222

G

mitogen activated protein kinase 14

decreases response to substance
multiple interactions

MAPK14 results in decreased susceptibility to afimoxifene
[afimoxifene co-treated with 4-hydroxycyclophosphamide] affects the expression of MAPK14 mRNA

PMID:21233418 PMID:25833159

NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589

G

mitogen activated protein kinase 3

increases phosphorylation
multiple interactions

afimoxifene results in increased phosphorylation of MAPK3 protein
[BRAF protein co-treated with afimoxifene] results in increased phosphorylation of MAPK3 protein; afimoxifene inhibits the reaction [Estradiol results in increased phosphorylation of MAPK3 protein]; afimoxifene inhibits the reaction [Glyphosate results in increased phosphorylation of MAPK3 protein]
afimoxifene inhibits the reaction [[bisphenol A co-treated with Glutamic Acid] results in increased phosphorylation of MAPK3 protein]

PMID:19549922 PMID:23624423 PMID:25645941 PMID:29890199 PMID:30707916

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

decreases response to substance

MAPK8 results in decreased susceptibility to afimoxifene

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

mitogen-activated protein kinase 9

decreases response to substance

MAPK9 results in decreased susceptibility to afimoxifene

NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178

G

microtubule affinity regulating kinase 4

decreases response to substance

MARK4 results in decreased susceptibility to afimoxifene

NCBI chr 1:79,075,353...79,108,882
Ensembl chr 1:79,068,904...79,108,556

G

matrin 3

decreases expression

afimoxifene results in decreased expression of MATR3 mRNA

NCBI chr18:27,154,098...27,193,212
Ensembl chr18:27,163,714...27,193,166

G

membrane bound O-acyltransferase domain containing 2

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of MBOAT2 mRNA]

NCBI chr 6:41,471,135...41,597,599
Ensembl chr 6:41,471,161...41,593,485

G

MCC regulator of WNT signaling pathway

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of MCC mRNA]

NCBI chr18:36,794,206...37,266,237
Ensembl chr18:36,798,372...37,266,819

G

malic enzyme 1

increases expression

afimoxifene results in increased expression of ME1 mRNA

NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304

G

MYST/Esa1-associated factor 6

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of MEAF6 mRNA]

NCBI chr 5:137,344,681...137,369,703
Ensembl chr 5:137,344,380...137,370,014

G

multiple EGF-like-domains 9

decreases expression

afimoxifene results in decreased expression of MEGF9 mRNA

NCBI chr 5:83,993,565...84,105,622
Ensembl chr 5:83,993,565...84,105,622

G

MET proto-oncogene, receptor tyrosine kinase

decreases expression

afimoxifene results in decreased expression of MET mRNA

NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876

G

matrix Gla protein

decreases expression

afimoxifene results in decreased expression of MGP mRNA

NCBI chr 4:169,766,290...169,769,612
Ensembl chr 4:169,766,279...169,769,667

G

microRNA 21

increases expression
multiple interactions

afimoxifene results in increased expression of MIR21 mRNA
afimoxifene inhibits the reaction [Estradiol results in decreased expression of MIR21 mRNA]

NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348

G

matrix metallopeptidase 12

decreases expression

afimoxifene results in decreased expression of MMP12 mRNA

NCBI chr 8:4,581,785...4,591,687
Ensembl chr 8:4,581,785...4,599,611

G

matrix metallopeptidase 13

increases expression

afimoxifene results in increased expression of MMP13 mRNA

NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239

G

matrix metallopeptidase 15

decreases expression

afimoxifene results in decreased expression of MMP15 mRNA

NCBI chr19:9,663,449...9,684,943
Ensembl chr19:9,663,449...9,684,943

G

matrix metallopeptidase 16

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of MMP16 mRNA]

NCBI chr 5:31,312,280...31,556,276
Ensembl chr 5:31,312,280...31,548,388

G

melanoregulin

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of MREG mRNA]

NCBI chr 9:73,786,727...73,842,081
Ensembl chr 9:73,787,267...73,842,087

G

mitochondrial ribosomal protein S2

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of MRPS2 mRNA]

NCBI chr 3:11,803,044...11,806,341
Ensembl chr 3:11,801,310...11,806,313

G

mutS homolog 2

increases expression

afimoxifene results in increased expression of MSH2 mRNA

NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938

G

metallothionein 1

increases expression
multiple interactions

afimoxifene results in increased expression of MT1A mRNA
GPER1 protein affects the reaction [afimoxifene results in increased expression of MT1A mRNA]

NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049

G

metallothionein 2A

multiple interactions
increases expression

GPER1 protein affects the reaction [afimoxifene results in increased expression of MT2A mRNA]

NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784

G

mechanistic target of rapamycin kinase

decreases response to substance
multiple interactions

MTOR results in decreased susceptibility to afimoxifene
[Sirolimus results in decreased activity of MTOR protein] which results in increased susceptibility to afimoxifene

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

MYB proto-oncogene, transcription factor

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of MYB mRNA]

NCBI chr 1:15,939,771...15,973,367
Ensembl chr 1:15,939,761...15,973,057

G

MYB proto-oncogene like 1

increases expression

afimoxifene results in increased expression of MYBL1 mRNA

NCBI chr 5:9,582,905...9,618,179
Ensembl chr 5:9,582,934...9,618,183

G

MYC proto-oncogene, bHLH transcription factor

increases expression
multiple interactions

afimoxifene results in increased expression of MYC mRNA
afimoxifene inhibits the reaction [Estradiol results in increased expression of MYC mRNA]; afimoxifene inhibits the reaction [Estrogens results in increased expression of MYC mRNA]; methylselenic acid inhibits the reaction [afimoxifene results in increased expression of MYC mRNA]; SU 6656 inhibits the reaction [afimoxifene results in increased expression of MYC mRNA]

PMID:15072547 PMID:15528270 PMID:16093440 PMID:21233418 PMID:27514991

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

myosin regulatory light chain interacting protein

decreases expression

afimoxifene results in decreased expression of MYLIP mRNA

NCBI chr17:19,286,649...19,308,295
Ensembl chr17:19,286,650...19,308,295

G

myosin light chain kinase

decreases expression

afimoxifene results in decreased expression of MYLK mRNA

NCBI chr11:65,783,008...66,030,239
Ensembl chr11:65,783,008...66,030,261

G

myosin Ib

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of MYO1B mRNA]

NCBI chr 9:49,690,043...49,852,373
Ensembl chr 9:49,690,086...49,850,798

G

myoferlin

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of MYOF mRNA]

NCBI chr 1:235,673,666...235,822,413
Ensembl chr 1:235,673,666...235,822,334

G

Ngfi-A binding protein 2

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of NAB2 mRNA]

NCBI chr 7:63,497,589...63,504,105
Ensembl chr 7:63,497,589...63,503,989

G

NEDD8 activating enzyme E1 subunit 1

affects response to substance

NAE1 gene affects the susceptibility to afimoxifene

NCBI chr19:446,015...472,145
Ensembl chr19:446,000...472,371

G

Nanog homeobox

increases expression

afimoxifene results in increased expression of NANOG protein

NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116

G

asparaginyl-tRNA synthetase 1

decreases expression

afimoxifene results in decreased expression of NARS1 mRNA

NCBI chr18:57,989,308...58,005,584
Ensembl chr18:57,989,308...58,005,622

G

N-acetyltransferase 9

decreases expression

afimoxifene results in decreased expression of NAT9 mRNA

NCBI chr10:100,422,326...100,427,510
Ensembl chr10:100,422,331...100,427,611

G

non-SMC condensin I complex, subunit H

decreases expression

afimoxifene results in decreased expression of NCAPH mRNA

NCBI chr 3:114,371,937...114,399,178
Ensembl chr 3:114,371,941...114,399,180

G

nucleolin

decreases expression

afimoxifene results in decreased expression of NCL mRNA

NCBI chr 9:86,999,588...87,008,112
Ensembl chr 9:86,998,019...87,008,136

G

nuclear receptor coactivator 1

multiple interactions

afimoxifene inhibits the reaction [ESRRG protein binds to NCOA1 protein]

NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664

G

nuclear receptor coactivator 2

multiple interactions

afimoxifene inhibits the reaction [[Estradiol co-treated with ESR1 protein] results in increased activity of NCOA2 protein]; afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]; benzylparaben inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]; bisphenol A inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]; butylparaben inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]; ethyl salicylate inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]; ethyl-p-hydroxybenzoate inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]; methyl salicylate inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]; methylparaben inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]; propylparaben inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]

PMID:23583298 PMID:28248286

NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451

G

nuclear receptor coactivator 3

multiple interactions

afimoxifene inhibits the reaction [Estradiol results in increased activity of NCOA3 protein]

NCBI chr 3:154,738,566...154,821,395
Ensembl chr 3:154,738,581...154,818,594

G

nuclear receptor co-repressor 1

multiple interactions

afimoxifene promotes the reaction [NCOR1 protein binds to TFF1 promoter]

NCBI chr10:46,999,536...47,142,294
Ensembl chr10:46,999,536...47,141,032

G

NADH:ubiquinone oxidoreductase subunit A10

decreases response to substance

NDUFA10 results in decreased susceptibility to afimoxifene

NCBI chr 9:93,007,034...93,041,825
Ensembl chr 9:93,007,042...93,042,560

G

neurofilament medium chain

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of NEFM mRNA]

NCBI chr15:42,360,449...42,365,753
Ensembl chr15:42,360,454...42,365,755

G

nei-like DNA glycosylase 2

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of NEIL2 mRNA]

NCBI chr15:37,444,676...37,454,863
Ensembl chr15:37,445,381...37,454,863

G

neurofibromin 1

affects response to substance

NF1 gene affects the susceptibility to afimoxifene

NCBI chr10:64,306,027...64,539,112
Ensembl chr10:64,306,301...64,536,658

G

NFKB inhibitor alpha

increases expression
multiple interactions

afimoxifene results in increased expression of NFKBIA mRNA
GPER1 protein affects the reaction [afimoxifene results in increased expression of NFKBIA mRNA]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

niban apoptosis regulator 1

increases expression

afimoxifene results in increased expression of NIBAN1 mRNA

NCBI chr13:63,674,240...63,827,748
Ensembl chr13:63,674,171...63,827,729

G

NIPBL, cohesin loading factor

affects response to substance

NIPBL gene affects the susceptibility to afimoxifene

NCBI chr 2:57,399,443...57,586,770
Ensembl chr 2:57,399,445...57,565,899

G

NME/NM23 nucleoside diphosphate kinase 3

decreases response to substance

NME3 results in decreased susceptibility to afimoxifene

NCBI chr10:13,917,309...13,918,415
Ensembl chr10:13,917,403...13,918,359

G

NME/NM23 nucleoside diphosphate kinase 4

decreases response to substance

NME4 results in decreased susceptibility to afimoxifene

NCBI chr10:15,114,624...15,118,479
Ensembl chr10:15,002,926...15,118,479

G

NME/NM23 family member 7

decreases response to substance

NME7 results in decreased susceptibility to afimoxifene

NCBI chr13:76,657,303...76,786,768
Ensembl chr13:76,657,367...76,786,765

G

NOC3-like DNA replication regulator

affects response to substance

NOC3L gene affects the susceptibility to afimoxifene

NCBI chr 1:236,556,037...236,585,372
Ensembl chr 1:236,556,789...236,585,318

G

nucleolar and coiled-body phosphoprotein 1

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of NOLC1 mRNA]

NCBI chr 1:244,921,275...244,932,089
Ensembl chr 1:244,921,377...244,932,088

G

NOP56 ribonucleoprotein

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of NOP56 mRNA]

NCBI chr 3:117,476,963...117,481,847
Ensembl chr 3:117,477,053...117,481,841

G

aminopeptidase puromycin sensitive

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of NPEPPS mRNA]

NCBI chr10:82,191,454...82,273,967
Ensembl chr10:82,191,456...82,273,967

G

nucleophosmin 1

decreases expression

afimoxifene results in decreased expression of NPM1 mRNA

NCBI chr10:17,741,512...17,751,626
Ensembl chr10:17,739,941...17,751,645

G

natriuretic peptide receptor 2

decreases response to substance

NPR2 results in decreased susceptibility to afimoxifene

NCBI chr 5:57,883,171...57,901,590
Ensembl chr 5:57,883,171...57,901,580

G

neuropeptide Y receptor Y1

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of NPY1R mRNA]

NCBI chr16:23,037,788...23,047,330
Ensembl chr16:23,037,789...23,046,759

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions
increases activity

afimoxifene binds to and results in increased activity of NR1I2 protein
afimoxifene results in increased activity of NR1I2 protein

PMID:15885729 PMID:16054614 PMID:33049310

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

nuclear receptor subfamily 4, group A, member 1

increases expression

afimoxifene results in increased expression of NR4A1 mRNA

NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297

G

nuclear receptor subfamily 4, group A, member 2

multiple interactions
increases expression

GPER1 protein affects the reaction [afimoxifene results in increased expression of NR4A2 mRNA]

NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877

G

nuclear respiratory factor 1

increases expression
multiple interactions

afimoxifene results in increased expression of NRF1 mRNA
fulvestrant inhibits the reaction [afimoxifene results in increased expression of NRF1 mRNA]; Vehicle Emissions inhibits the reaction [afimoxifene results in increased expression of NRF1 mRNA]

NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328

G

neuregulin 3

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of NRG3 mRNA]

NCBI chr16:14,229,270...15,352,505
Ensembl chr16:14,235,157...15,352,368

G

nuclear receptor interacting protein 1

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of NRIP1 mRNA]

NCBI chr11:14,895,843...14,979,490
Ensembl chr11:14,895,553...14,981,761

G

nuclear receptor binding SET domain protein 1

affects response to substance

NSD1 gene affects the susceptibility to afimoxifene

NCBI chr17:9,311,963...9,426,373
Ensembl chr17:9,315,237...9,425,358

G

NUS1 dehydrodolichyl diphosphate synthase subunit

decreases expression

afimoxifene results in decreased expression of NUS1 mRNA

NCBI chr20:31,811,817...31,838,562
Ensembl chr20:31,811,817...31,838,561

G

NUT midline carcinoma, family member 1

affects response to substance

NUTM1 gene affects the susceptibility to afimoxifene

NCBI chr 3:99,053,510...99,064,311
Ensembl chr 3:99,053,510...99,064,311

G

nuclear transport factor 2-like export factor 1

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of NXT1 mRNA]

NCBI chr 3:136,108,975...136,111,897
Ensembl chr 3:136,108,862...136,111,907

G

ornithine decarboxylase antizyme 3

increases expression

afimoxifene results in increased expression of OAZ3 mRNA

NCBI chr 2:182,073,212...182,076,147
Ensembl chr 2:182,073,215...182,082,399

G

2-oxoglutarate and iron-dependent oxygenase domain containing 1

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of OGFOD1 mRNA]

NCBI chr19:10,945,031...10,974,602
Ensembl chr19:10,946,018...10,975,119

G

olfactomedin 1

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of OLFM1 mRNA]

NCBI chr 3:11,520,522...11,558,240
Ensembl chr 3:11,520,729...11,558,239

G

olfactomedin 4

increases expression

afimoxifene results in increased expression of OLFM4 mRNA

NCBI chr15:55,385,100...55,429,687
Ensembl chr15:55,407,148...55,429,681

G

peptidyl arginine deiminase 1

increases expression

afimoxifene results in increased expression of PADI1 mRNA

NCBI chr 5:153,119,566...153,152,034
Ensembl chr 5:153,119,566...153,152,034

G

peptidyl arginine deiminase 2

increases expression

afimoxifene results in increased expression of PADI2 mRNA

NCBI chr 5:153,209,053...153,251,632
Ensembl chr 5:153,209,053...153,251,632

G

p21 (RAC1) activated kinase 6

decreases response to substance

PAK6 results in decreased susceptibility to afimoxifene

NCBI chr 3:105,638,248...105,674,399
Ensembl chr 3:105,638,653...105,672,975

G

3'-phosphoadenosine 5'-phosphosulfate synthase 1

decreases response to substance

PAPSS1 results in decreased susceptibility to afimoxifene

NCBI chr 2:220,040,343...220,114,399
Ensembl chr 2:220,040,312...220,114,395

G

paired box 7

decreases expression

afimoxifene results in decreased expression of PAX7 mRNA

NCBI chr 5:151,996,368...152,098,023
Ensembl chr 5:151,999,092...152,097,979

G

protocadherin 8

increases expression

afimoxifene results in increased expression of PCDH8 mRNA

NCBI chr15:55,198,470...55,203,039
Ensembl chr15:55,198,459...55,205,872

G

PC-esterase domain containing 1B

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of PCED1B mRNA]

NCBI chr 7:128,394,388...128,528,231
Ensembl chr 7:128,391,319...128,528,231

G

PCNA clamp associated factor

decreases expression

afimoxifene results in decreased expression of PCLAF mRNA

NCBI chr 8:66,420,606...66,432,994
Ensembl chr 8:66,420,587...66,432,994
Ensembl chr 8:66,420,587...66,432,994

G

proliferating cell nuclear antigen

increases expression
decreases expression
multiple interactions

afimoxifene results in increased expression of PCNA protein
afimoxifene results in decreased expression of PCNA mRNA
[afimoxifene results in decreased susceptibility to Estradiol] which results in decreased expression of PCNA protein; [afimoxifene results in decreased susceptibility to Glyphosate] which results in decreased expression of PCNA protein

PMID:10965916 PMID:15072547 PMID:29890199

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

G

prenylcysteine oxidase 1

increases expression

afimoxifene results in increased expression of PCYOX1 mRNA

NCBI chr 4:118,832,114...118,842,951
Ensembl chr 4:118,830,638...118,842,951

G

programmed cell death 4

decreases expression

afimoxifene results in decreased expression of PDCD4 mRNA

NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275

G

PDZ domain containing 1

increases expression

afimoxifene results in increased expression of PDZK1 mRNA

NCBI chr 2:184,376,161...184,407,514
Ensembl chr 2:184,376,161...184,407,514

G

pescadillo ribosomal biogenesis factor 1

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of PES1 mRNA]

NCBI chr14:78,850,754...78,867,134
Ensembl chr14:78,850,709...78,867,134

G

progesterone receptor

decreases expression
multiple interactions
increases expression

afimoxifene results in decreased expression of PGR mRNA
[Resveratrol co-treated with pterostilbene] promotes the reaction [afimoxifene results in decreased expression of PGR mRNA]; afimoxifene inhibits the reaction [deoxynivalenol results in increased expression of PGR mRNA]; afimoxifene inhibits the reaction [Estradiol results in increased expression of PGR mRNA]
afimoxifene results in increased expression of PGR mRNA

PMID:15072547 PMID:26879975 PMID:27159275 PMID:33769548 PMID:35588983

NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344

G

progesterone receptor membrane component 1

increases expression

afimoxifene results in increased expression of PGRMC1 mRNA

NCBI chr X:115,832,865...115,841,060
Ensembl chr X:115,832,884...115,888,682

G

phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of PIK3C2B mRNA]

NCBI chr13:44,494,673...44,555,663
Ensembl chr13:44,495,050...44,555,612

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma

decreases response to substance

PIK3CG results in decreased susceptibility to afimoxifene

NCBI chr 6:48,766,778...48,802,098
Ensembl chr 6:48,766,864...48,802,043

G

phosphoinositide-3-kinase regulatory subunit 3

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of PIK3R3 mRNA]

NCBI chr 5:129,700,925...129,772,591
Ensembl chr 5:129,701,229...129,772,583

G

cAMP-dependent protein kinase inhibitor alpha

increases expression

afimoxifene results in increased expression of PKIA mRNA

NCBI chr 2:94,398,869...94,473,638
Ensembl chr 2:94,398,869...94,414,282

G

pleckstrin homology and FYVE domain containing 1

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of PLEKHF1 mRNA]

NCBI chr 1:90,908,304...90,915,862
Ensembl chr 1:90,904,742...90,915,820

G

plastin 1

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of PLS1 mRNA]

NCBI chr 8:96,316,703...96,426,592
Ensembl chr 8:96,317,849...96,385,195

G

peripheral myelin protein 22

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of PMP22 mRNA]

NCBI chr10:47,795,709...47,825,715
Ensembl chr10:47,795,709...47,825,714

G

phosphomevalonate kinase

decreases response to substance

PMVK results in decreased susceptibility to afimoxifene

NCBI chr 2:174,876,586...174,886,365
Ensembl chr 2:174,876,657...174,886,364

G

partner of NOB1 homolog

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of PNO1 mRNA]

NCBI chr14:91,609,711...91,618,280
Ensembl chr14:91,609,233...91,618,324

G

purine nucleoside phosphorylase

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of PNP mRNA]

NCBI chr15:24,170,607...24,178,269
Ensembl chr15:24,170,602...24,203,986

G

RNA polymerase II subunit B

decreases expression

afimoxifene results in decreased expression of POLR2B mRNA

NCBI chr14:30,797,228...30,834,916
Ensembl chr14:30,797,228...30,834,916

G

peroxisome proliferator-activated receptor gamma

multiple interactions

afimoxifene binds to and results in increased activity of PPARG protein; afimoxifene inhibits the reaction [PPARG protein binds to CD36 promoter]; afimoxifene inhibits the reaction [PPARG protein results in increased expression of CD36 mRNA]; afimoxifene results in decreased expression of and results in increased phosphorylation of PPARG protein
afimoxifene binds to and results in increased activity of PPARG protein; PPARG mRNA promotes the reaction [afimoxifene results in decreased expression of CD36 protein]

PMID:27358406 PMID:33049310

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

PPARG coactivator 1 alpha

multiple interactions

afimoxifene inhibits the reaction [PPARGC1A protein binds to ESRRG protein]

NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656

G

peptidylprolyl isomerase F

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of PPIF mRNA]

NCBI chr16:1,257,197...1,263,919
Ensembl chr16:1,257,106...1,263,913

G

protein phosphatase, Mg2+/Mn2+ dependent, 1D

decreases expression

afimoxifene results in decreased expression of PPM1D mRNA

NCBI chr10:70,172,603...70,208,607
Ensembl chr10:70,172,603...70,208,607

G

protein phosphatase, Mg2+/Mn2+ dependent, 1K

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of PPM1K mRNA]

NCBI chr 4:87,612,198...87,638,993
Ensembl chr 4:87,612,204...87,636,152

G

protein phosphatase 1, regulatory subunit 15A

multiple interactions
increases expression

GPER1 protein affects the reaction [afimoxifene results in increased expression of PPP1R15A mRNA]

NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171

G

protein phosphatase 1, regulatory subunit 15B

affects response to substance

PPP1R15B gene affects the susceptibility to afimoxifene

NCBI chr13:44,577,840...44,585,737
Ensembl chr13:44,577,932...44,585,737

G

protein phosphatase 4, regulatory subunit 3B

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of PPP4R3B mRNA]

NCBI chr14:102,917,043...102,965,210
Ensembl chr14:102,917,443...103,068,192

G

prolylcarboxypeptidase

decreases response to substance

PRCP protein results in decreased susceptibility to afimoxifene

NCBI chr 1:146,931,487...146,983,891
Ensembl chr 1:146,930,561...146,984,530

G

protein kinase AMP-activated catalytic subunit alpha 1

decreases response to substance

PRKAA1 results in decreased susceptibility to afimoxifene

NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978

G

protein kinase C, delta

decreases response to substance

PRKCD results in decreased susceptibility to afimoxifene

NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352

G

protein kinase C, zeta

decreases response to substance

PRKCZ results in decreased susceptibility to afimoxifene

NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367

G

protein kinase, DNA-activated, catalytic subunit

decreases expression

afimoxifene results in decreased expression of PRKDC mRNA

NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952

G

proline dehydrogenase

decreases expression

afimoxifene results in decreased expression of PRODH mRNA

NCBI chr11:82,910,043...82,927,305
Ensembl chr11:82,910,137...82,927,305

G

phosphoribosyl pyrophosphate synthetase 1

increases expression

afimoxifene results in increased expression of PRPS1 mRNA

NCBI chr X:104,132,139...104,154,191
Ensembl chr X:104,132,141...104,154,187

G

serine protease 8

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of PRSS8 mRNA]

NCBI chr 1:182,536,229...182,540,745
Ensembl chr 1:182,536,229...182,540,815

G

proteasome 26S subunit, non-ATPase 14

decreases expression

afimoxifene results in decreased expression of PSMD14 mRNA

NCBI chr 3:46,254,338...46,347,076
Ensembl chr 3:46,254,330...46,347,076

G

proteasome 26S subunit, non-ATPase 6

decreases expression

afimoxifene results in decreased expression of PSMD6 mRNA

NCBI chr15:11,102,174...11,112,180
Ensembl chr15:11,102,180...11,205,620

G

proteasome activator subunit 4

decreases expression

afimoxifene results in decreased expression of PSME4 mRNA

NCBI chr14:104,505,716...104,609,410
Ensembl chr14:104,505,716...104,609,408

G

prostaglandin E receptor 4

increases expression
multiple interactions

afimoxifene results in increased expression of PTGER4 mRNA
GPER1 protein affects the reaction [afimoxifene results in increased expression of PTGER4 mRNA]

NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670

G

prostaglandin E synthase

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of PTGES mRNA]

NCBI chr 3:14,177,892...14,189,236

G

parathyroid hormone-like hormone

increases secretion

afimoxifene results in increased secretion of PTHLH protein

NCBI chr 4:180,188,792...180,199,847
Ensembl chr 4:180,188,792...180,199,847

G

protein tyrosine phosphatase, non-receptor type 11

decreases activity

afimoxifene results in decreased activity of PTPN11 protein

NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925

G

protein tyrosine phosphatase, non-receptor type 12

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of PTPN12 mRNA]

NCBI chr 4:14,020,997...14,092,931
Ensembl chr 4:14,021,052...14,092,927

G

protein tyrosine phosphatase, non-receptor type 6

decreases activity

afimoxifene results in decreased activity of PTPN6 protein

NCBI chr 4:157,526,034...157,550,783
Ensembl chr 4:157,526,035...157,550,984

G

protein tyrosine phosphatase, receptor type, G

multiple interactions
increases expression

Estradiol inhibits the reaction [afimoxifene results in increased expression of PTPRG mRNA]; Fulvestrant inhibits the reaction [afimoxifene results in increased expression of PTPRG mRNA]

NCBI chr15:12,871,706...13,552,186
Ensembl chr15:12,871,721...13,554,094

G

PWWP domain containing 3B

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of PWWP3B mRNA]

NCBI chr X:102,804,416...102,838,580
Ensembl chr X:102,804,520...102,838,574

G

RAB27B, member RAS oncogene family

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of RAB27B mRNA]

NCBI chr18:63,597,554...63,794,124
Ensembl chr18:63,600,937...63,757,180

G

RAB30, member RAS oncogene family

increases expression
multiple interactions

afimoxifene results in increased expression of RAB30 mRNA
ESR2 protein inhibits the reaction [afimoxifene results in increased expression of RAB30 mRNA]; Estradiol inhibits the reaction [afimoxifene results in increased expression of RAB30 mRNA]; Fulvestrant inhibits the reaction [afimoxifene results in increased expression of RAB30 mRNA]

NCBI chr 1:146,803,719...146,898,369
Ensembl chr 1:146,803,714...146,892,181

G

RAB31, member RAS oncogene family

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of RAB31 mRNA]

NCBI chr 9:105,246,712...105,382,973
Ensembl chr 9:105,246,709...105,381,253

G

Rac GTPase-activating protein 1

decreases expression

afimoxifene results in decreased expression of RACGAP1 mRNA

NCBI chr 7:130,750,936...130,780,891
Ensembl chr 7:130,750,936...130,780,831

G

RAD21 cohesin complex component

affects response to substance

RAD21 gene affects the susceptibility to afimoxifene

NCBI chr 7:83,287,867...83,314,810
Ensembl chr 7:83,287,870...83,314,817

G

Raf-1 proto-oncogene, serine/threonine kinase

decreases response to substance

RAF1 results in decreased susceptibility to afimoxifene

NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317

G

RAP1A, member of RAS oncogene family

decreases expression

afimoxifene results in decreased expression of RAP1A mRNA

NCBI chr 2:193,208,631...193,286,513
Ensembl chr 2:193,208,635...193,286,501

G

retinoic acid receptor, alpha

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of RARA mRNA]

NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142

G

retinoic acid receptor, gamma

affects response to substance

RARG gene affects the susceptibility to afimoxifene

NCBI chr 7:133,367,833...133,390,301
Ensembl chr 7:133,367,833...133,390,177

G

ras related dexamethasone induced 1

multiple interactions
increases expression

GPER1 protein affects the reaction [afimoxifene results in increased expression of RASD1 mRNA]

NCBI chr10:44,766,451...44,775,773
Ensembl chr10:44,766,455...44,768,186

G

RAS guanyl releasing protein 1

increases expression

afimoxifene results in increased expression of RASGRP1 mRNA

NCBI chr 3:104,168,549...104,230,107
Ensembl chr 3:104,170,013...104,230,056

G

RB binding protein 7, chromatin remodeling factor

decreases expression

afimoxifene results in decreased expression of RBBP7 mRNA

NCBI chr X:31,913,080...31,931,245
Ensembl chr X:31,913,081...31,931,226

G

ribokinase

decreases response to substance

RBKS results in decreased susceptibility to afimoxifene

NCBI chr 6:24,747,651...24,824,290
Ensembl chr 6:24,747,293...24,824,290

G

RNA binding motif protein 24

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of RBM24 mRNA]

NCBI chr17:18,275,681...18,288,231
Ensembl chr17:18,275,688...18,288,102

G

RNA terminal phosphate cyclase-like 1

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of RCL1 mRNA]

NCBI chr 1:226,824,561...226,869,046
Ensembl chr 1:226,824,534...226,902,315

G

ret proto-oncogene

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of RET mRNA]

NCBI chr 4:151,325,969...151,368,176
Ensembl chr 4:151,326,431...151,368,176

G

regulator of G-protein signaling 16

increases expression
multiple interactions

afimoxifene results in increased expression of RGS16 mRNA
GPER1 protein affects the reaction [afimoxifene results in increased expression of RGS16 mRNA]

NCBI chr13:65,887,668...65,892,862
Ensembl chr13:65,887,530...65,892,857

G

regulator of G-protein signaling 3

increases expression

afimoxifene results in increased expression of RGS3 mRNA

NCBI chr 5:76,022,038...76,161,895
Ensembl chr 5:76,022,001...76,161,894

G

rhomboid 5 homolog 1

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of RHBDF1 mRNA]

NCBI chr10:15,406,832...15,419,765
Ensembl chr10:15,406,859...15,419,763

G

rhomboid like 2

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of RHBDL2 mRNA]

NCBI chr 5:136,037,560...136,081,970
Ensembl chr 5:136,037,305...136,081,969

G

Rho-related BTB domain containing 1

increases expression

afimoxifene results in increased expression of RHOBTB1 mRNA

NCBI chr20:19,327,142...19,456,121
Ensembl chr20:19,327,155...19,403,012

G

ras homolog family member T1

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of RHOT1 mRNA]

NCBI chr10:65,198,700...65,262,807
Ensembl chr10:65,170,560...65,262,804

G

Rho family GTPase 1

multiple interactions
increases expression

afimoxifene inhibits the reaction [Estrogens results in decreased expression of RND1 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of RND1 mRNA]

PMID:19153601 PMID:21233418

NCBI chr 7:129,821,311...129,828,385
Ensembl chr 7:129,821,311...129,828,399

G

ring finger protein 114

decreases expression

afimoxifene results in decreased expression of RNF114 mRNA

NCBI chr 3:156,222,487...156,234,263
Ensembl chr 3:156,222,498...156,234,256

G

ribosomal protein L6

decreases expression

afimoxifene results in decreased expression of RPL6 mRNA

NCBI chr12:35,347,493...35,352,011
Ensembl chr12:35,347,497...35,351,921

G

ribonuclease P and MRP subunit p25

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of RPP25 mRNA]

NCBI chr 8:57,907,352...57,908,732
Ensembl chr 8:57,907,352...57,908,732

G

ribonuclease P RNA component H1

increases expression

afimoxifene results in increased expression of RPPH1 mRNA

NCBI chr15:24,033,679...24,033,935
Ensembl chr15:24,033,662...24,033,959

G

ribosomal protein S6 kinase A6

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of RPS6KA6 mRNA]

NCBI chr X:76,353,316...76,454,502
Ensembl chr X:76,353,760...76,454,484

G

ribosomal protein S6 kinase-like 1

decreases response to substance

RPS6KL1 results in decreased susceptibility to afimoxifene

NCBI chr 6:104,783,227...104,799,895
Ensembl chr 6:104,783,258...104,799,869

G

RAS related 2

affects response to substance

RRAS2 gene affects the susceptibility to afimoxifene

NCBI chr 1:168,233,693...168,303,111
Ensembl chr 1:168,233,693...168,303,111

G

ribonucleotide reductase catalytic subunit M1

decreases expression

afimoxifene results in decreased expression of RRM1 mRNA

NCBI chr 1:156,823,960...156,848,262
Ensembl chr 1:156,823,960...156,848,261

G

ribosome biogenesis regulator 1 homolog

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of RRS1 mRNA]

NCBI chr 5:9,733,486...9,735,119
Ensembl chr 5:9,733,091...9,735,140

G

radial spoke head 10 homolog B

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of RSPH10B mRNA]

NCBI chr12:10,627,434...10,675,227
Ensembl chr12:10,627,435...10,675,167

G

retinoid X receptor alpha

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of RXRA mRNA]

NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712

G

S100 calcium binding protein A6

multiple interactions

afimoxifene inhibits the reaction [Estradiol results in increased expression of S100A6 protein]

NCBI chr 2:176,100,619...176,102,181
Ensembl chr 2:176,100,899...176,102,180

G

schwannomin interacting protein 1

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of SCHIP1 mRNA]

NCBI chr 2:152,127,171...152,888,587
Ensembl chr 2:152,126,953...152,888,585

G

SCY1 like pseudokinase 3

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of SCYL3 mRNA]

NCBI chr13:76,278,428...76,303,038
Ensembl chr13:76,278,428...76,301,716

G

syndecan 1

increases expression

afimoxifene results in increased expression of SDC1 mRNA

NCBI chr 6:31,562,799...31,585,267
Ensembl chr 6:31,562,739...31,585,264

G

stromal cell-derived factor 2-like 1

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of SDF2L1 mRNA]

NCBI chr11:83,872,659...83,874,902
Ensembl chr11:83,872,659...83,874,902

G

selectin L

increases expression

afimoxifene results in increased expression of SELL mRNA

NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456

G

semaphorin 3C

increases expression

afimoxifene results in increased expression of SEMA3C mRNA

NCBI chr 4:17,583,212...17,747,234
Ensembl chr 4:17,583,212...17,746,534

G

semaphorin 3G

decreases expression

afimoxifene results in decreased expression of SEMA3G mRNA

NCBI chr16:6,413,589...6,425,221
Ensembl chr16:6,413,589...6,425,221

G

serpin family A member 1

increases expression

afimoxifene results in increased expression of SERPINA1 mRNA

NCBI chr 6:122,866,314...122,888,339
Ensembl chr 6:122,866,312...122,888,339

G

serpin family B member 9

increases expression
multiple interactions

afimoxifene results in increased expression of SERPINB9 mRNA
ESR1 protein promotes the reaction [afimoxifene results in increased expression of SERPINB9 mRNA]

PMID:14617632 PMID:17237823

NCBI chr17:31,420,118...31,443,237
Ensembl chr17:31,420,125...31,443,230

G

sestrin 1

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of SESN1 mRNA]

NCBI chr20:45,294,876...45,387,698
Ensembl chr20:45,294,871...45,387,697

G

splicing factor proline and glutamine rich

decreases expression

afimoxifene results in decreased expression of SFPQ mRNA

NCBI chr 5:139,338,034...139,353,476
Ensembl chr 5:139,338,075...139,353,472

G

sideroflexin 2

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of SFXN2 mRNA]

NCBI chr 1:245,447,014...245,459,312
Ensembl chr 1:245,447,015...245,468,411
Ensembl chr 1:245,447,015...245,468,411

G

serum/glucocorticoid regulated kinase family, member 3

decreases response to substance

SGK3 results in decreased susceptibility to afimoxifene

NCBI chr 5:9,345,761...9,472,243
Ensembl chr 5:9,346,040...9,415,476

G

SH3-domain binding protein 4

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of SH3BP4 mRNA]

NCBI chr 9:89,660,156...89,739,163
Ensembl chr 9:89,660,156...89,739,163

G

SH3 domain containing ring finger 1

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of SH3RF1 mRNA]

NCBI chr16:28,735,522...28,901,261
Ensembl chr16:28,735,440...28,901,644

G

SH3 and multiple ankyrin repeat domains 2

increases expression

afimoxifene results in increased expression of SHANK2 mRNA

NCBI chr 1:199,146,210...199,590,962
Ensembl chr 1:199,169,429...199,589,394

G

SH2 domain containing adaptor protein B

increases expression

afimoxifene results in increased expression of SHB mRNA

NCBI chr 5:59,678,066...59,785,443
Ensembl chr 5:59,678,216...59,785,538

G

sex hormone binding globulin

affects binding

afimoxifene binds to SHBG protein

NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057

G

shroom family member 2

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of SHROOM2 mRNA]

NCBI chr X:21,812,469...21,983,724
Ensembl chr X:21,812,469...21,984,153

G

siah E3 ubiquitin protein ligase 2

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of SIAH2 mRNA]

NCBI chr 2:142,913,924...142,931,752
Ensembl chr 2:142,914,003...142,931,950

G

solute carrier family 10 member 1

decreases expression

afimoxifene results in decreased expression of SLC10A1 mRNA

NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670

G

solute carrier family 1 member 1

decreases expression

afimoxifene results in decreased expression of SLC1A1 mRNA

NCBI chr 1:226,549,932...226,631,925
Ensembl chr 1:226,549,842...226,630,402

G

solute carrier family 22 member 5

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of SLC22A5 mRNA]

NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309

G

solute carrier family 25 member 1

increases expression

afimoxifene results in increased expression of SLC25A1 mRNA

NCBI chr11:83,055,764...83,058,781
Ensembl chr11:83,055,748...83,058,781

G

solute carrier family 25 member 15

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of SLC25A15 mRNA]

NCBI chr16:69,631,581...69,654,869
Ensembl chr16:69,634,414...69,653,010

G

solute carrier family 25 member 28

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of SLC25A28 mRNA]

NCBI chr 1:242,530,877...242,542,140
Ensembl chr 1:242,530,899...242,542,115

G

solute carrier family 26 member 2

decreases expression
multiple interactions

afimoxifene results in decreased expression of SLC26A2 mRNA
afimoxifene inhibits the reaction [Estrogens results in increased expression of SLC26A2 mRNA]

PMID:16514628 PMID:21233418

NCBI chr18:54,648,276...54,666,627
Ensembl chr18:54,652,951...54,666,626

G

solute carrier family 35, member G1

increases expression

afimoxifene results in increased expression of SLC35G1 mRNA

NCBI chr 1:236,163,593...236,172,115
Ensembl chr 1:236,163,175...236,170,262

G

solute carrier family 39 member 6

decreases expression

afimoxifene results in decreased expression of SLC39A6 mRNA

NCBI chr18:15,864,874...15,885,417
Ensembl chr18:15,864,875...15,885,417

G

solute carrier family 3 member 2

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of SLC3A2 mRNA]

NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931

G

solute carrier family 7 member 5

increases expression

afimoxifene results in increased expression of SLC7A5 mRNA

NCBI chr19:49,935,220...49,963,823
Ensembl chr19:49,935,220...49,963,823

G

solute carrier family 9 member A1

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of SLC9A1 mRNA]

NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624

G

slit guidance ligand 2

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of SLIT2 mRNA]

NCBI chr14:62,616,337...62,955,934
Ensembl chr14:62,617,067...62,955,948

G

structural maintenance of chromosomes 3

affects response to substance

SMC3 gene affects the susceptibility to afimoxifene

NCBI chr 1:252,601,422...252,644,522
Ensembl chr 1:252,601,753...252,644,522

G

sphingomyelin phosphodiesterase 1

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of SMPD1 mRNA]

NCBI chr 1:159,892,946...159,896,789
Ensembl chr 1:159,892,859...159,896,794

G

smoothelin

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of SMTN mRNA]

NCBI chr14:78,398,595...78,420,908
Ensembl chr14:78,397,778...78,420,886

G

small nuclear ribonucleoprotein D1 polypeptide

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of SNRPD1 mRNA]

NCBI chr18:1,696,838...1,707,400
Ensembl chr18:1,696,852...1,708,256

G

suppressor of cytokine signaling 1

multiple interactions
increases expression

[afimoxifene co-treated with Cycloheximide] results in increased expression of SOCS1 mRNA; ESR2 protein inhibits the reaction [afimoxifene results in increased expression of SOCS1 mRNA]; Estradiol inhibits the reaction [afimoxifene results in increased expression of SOCS1 mRNA]; Fulvestrant inhibits the reaction [afimoxifene results in increased expression of SOCS1 mRNA]

NCBI chr10:4,882,651...4,884,342
Ensembl chr10:4,882,560...4,884,383

G

suppressor of cytokine signaling 2

increases expression

afimoxifene results in increased expression of SOCS2 mRNA

NCBI chr 7:30,006,360...30,045,161
Ensembl chr 7:30,008,578...30,043,548

G

SON DNA and RNA binding protein

decreases expression

afimoxifene results in decreased expression of SON mRNA

NCBI chr11:30,850,890...30,923,167
Ensembl chr11:30,892,005...30,923,167

G

SRY-box transcription factor 9

multiple interactions
decreases expression

afimoxifene inhibits the reaction [Estrogens results in decreased expression of SOX9 mRNA]
afimoxifene results in decreased expression of SOX9 mRNA

PMID:16849584 PMID:21233418

NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994

G

sperm acrosome associated 6

decreases expression

afimoxifene results in decreased expression of SPACA6 mRNA

NCBI chr 1:58,672,128...58,689,309
Ensembl chr 1:58,677,797...58,688,562

G

sphingosine kinase 1

decreases response to substance

SPHK1 results in decreased susceptibility to afimoxifene

NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240

G

spectrin, beta, non-erythrocytic 1

decreases expression

afimoxifene results in decreased expression of SPTBN1 mRNA

NCBI chr14:103,841,713...104,016,900
Ensembl chr14:103,842,684...104,008,507

G

SRC proto-oncogene, non-receptor tyrosine kinase

multiple interactions

afimoxifene inhibits the reaction [icariin results in increased phosphorylation of SRC protein]

NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476

G

steroid 5 alpha-reductase 1

increases expression

afimoxifene results in increased expression of SRD5A1 mRNA

NCBI chr 1:33,686,069...33,720,468
Ensembl chr 1:33,686,391...33,720,461

G

spermidine synthase

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of SRM mRNA]

NCBI chr 5:159,025,875...159,029,076
Ensembl chr 5:159,025,873...159,029,405

G

serine and arginine rich splicing factor 1

decreases expression

afimoxifene results in decreased expression of SRSF1 mRNA

NCBI chr10:72,838,926...72,859,066
Ensembl chr10:72,839,274...72,845,336

G

serine and arginine rich splicing factor 7

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of SRSF7 mRNA]

NCBI chr 6:14,811,775...14,818,968
Ensembl chr 6:14,811,808...14,818,965

G

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of ST8SIA2 mRNA]

NCBI chr 1:127,762,573...127,838,017
Ensembl chr 1:127,762,573...127,838,091

G

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of ST8SIA4 mRNA]

NCBI chr 9:95,990,131...96,084,661
Ensembl chr 9:95,993,503...96,084,653

G

STAG1 cohesin complex component

increases expression

afimoxifene results in increased expression of STAG1 mRNA

NCBI chr 8:101,179,039...101,564,684
Ensembl chr 8:101,179,039...101,564,677

G

signal transducer and activator of transcription 1

decreases expression

afimoxifene results in decreased expression of STAT1 mRNA

NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540

G

stanniocalcin 2

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of STC2 mRNA]

NCBI chr10:16,251,046...16,260,815
Ensembl chr10:16,250,853...16,262,973

G

serine/threonine kinase 26

decreases expression

afimoxifene results in decreased expression of STK26 mRNA

NCBI chr X:130,325,064...130,375,674
Ensembl chr X:130,310,885...130,374,291

G

serine/threonine kinase-like domain containing 1

decreases response to substance

STKLD1 results in decreased susceptibility to afimoxifene

NCBI chr 3:10,261,583...10,280,850
Ensembl chr 3:10,261,828...10,280,566

G

stathmin 1

decreases expression

afimoxifene results in decreased expression of STMN1 mRNA

NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154

G

stomatin

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of STOM mRNA]

NCBI chr 3:18,645,058...18,667,343
Ensembl chr 3:18,644,378...18,667,354

G

STE20 related adaptor alpha

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of STRADA mRNA]

NCBI chr10:91,094,849...91,123,890
Ensembl chr10:91,094,687...91,123,830

G

steroid sulfatase

decreases expression

afimoxifene results in decreased expression of STS mRNA

NCBI chr X:42,225,131...42,233,403
Ensembl chr X:42,225,372...42,233,402

G

STIP1 homology and U-box containing protein 1

multiple interactions

afimoxifene inhibits the reaction [ESR1 protein binds to STUB1 protein]

NCBI chr10:14,850,765...14,853,046
Ensembl chr10:14,850,765...14,853,046

G

sulfotransferase family 1A member 1

affects response to substance
affects sulfation
increases sulfation
increases response to substance
increases metabolic processing
multiple interactions

SULT1A1 protein affects the susceptibility to afimoxifene
SULT1A1 gene polymorphism affects the sulfation of afimoxifene
SULT1A1 protein results in increased sulfation of afimoxifene
SULT1A1 protein results in increased susceptibility to afimoxifene
SULT1A1 protein results in increased metabolism of afimoxifene
[SULT1A1 3' UTR SNP affects the activity of SULT1A1 protein] which affects the metabolism of afimoxifene; [SULT1A1 protein results in increased metabolism of Tamoxifen] which results in increased abundance of afimoxifene

PMID:16517757 PMID:30120701

NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562

G

supervillin

decreases expression

afimoxifene results in decreased expression of SVIL mRNA

NCBI chr17:52,648,502...52,844,114
Ensembl chr17:52,648,502...52,793,404

G

symplekin scaffold protein

increases expression

afimoxifene results in increased expression of SYMPK mRNA

NCBI chr 1:78,672,372...78,700,684
Ensembl chr 1:78,672,378...78,700,684

G

synaptotagmin 1

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of SYT1 mRNA]

NCBI chr 7:43,813,204...44,358,020
Ensembl chr 7:43,815,785...44,357,803

G

transforming, acidic coiled-coil containing protein 1

decreases expression
multiple interactions

afimoxifene results in decreased expression of TACC1 mRNA; afimoxifene results in decreased expression of TACC1 protein
afimoxifene inhibits the reaction [Estrogens results in decreased expression of TACC1 mRNA]

PMID:15072547 PMID:18984771 PMID:21233418

NCBI chr16:66,812,232...66,895,736
Ensembl chr16:66,812,295...66,895,733

G

tumor-associated calcium signal transducer 2

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of TACSTD2 mRNA]

NCBI chr 4:96,707,950...96,709,650
Ensembl chr 4:96,707,951...96,709,650

G

TATA-box binding protein associated factor 9

decreases expression

afimoxifene results in decreased expression of TAF9 mRNA

NCBI chr 2:31,794,316...31,798,324
Ensembl chr 2:31,794,142...31,798,769

G

threonyl-tRNA synthetase 1

decreases expression

afimoxifene results in decreased expression of TARS1 mRNA

NCBI chr 2:60,368,893...60,387,715
Ensembl chr 2:60,367,796...60,387,717

G

transcription activation suppressor

increases expression

afimoxifene results in increased expression of TASOR mRNA

NCBI chr16:2,606,807...2,669,902
Ensembl chr16:2,603,936...2,667,292

G

TatD DNase domain containing 3

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of TATDN3 mRNA]

NCBI chr13:102,634,254...102,649,069
Ensembl chr13:102,634,258...102,649,063

G

T-box transcription factor 3

multiple interactions

PD 173074 inhibits the reaction [afimoxifene results in increased expression of TBX3 protein]

NCBI chr12:36,879,924...36,894,849
Ensembl chr12:36,881,445...36,893,708

G

transcription elongation factor A like 1

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of TCEAL1 mRNA]

NCBI chr X:100,058,485...100,060,439
Ensembl chr X:100,058,132...100,060,551

G

transcription factor 7 like 2

increases expression

afimoxifene results in increased expression of TCF7L2 mRNA

NCBI chr 1:254,785,956...254,978,967
Ensembl chr 1:254,786,091...254,978,967

G

transcription factor A, mitochondrial

increases expression

afimoxifene results in increased expression of TFAM mRNA

NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292

G

transcription factor AP-2 alpha

decreases expression

afimoxifene results in decreased expression of TFAP2A mRNA

NCBI chr17:24,028,716...24,047,507
Ensembl chr17:24,024,432...24,047,507

G

transcription factor AP-4

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of TFAP4 mRNA]

NCBI chr10:11,001,338...11,019,386
Ensembl chr10:11,002,911...11,019,386

G

trefoil factor 1

affects binding
decreases expression
multiple interactions
increases expression

[afimoxifene binds to ESR1 protein] which binds to TFF1 protein
afimoxifene results in decreased expression of TFF1 mRNA
afimoxifene inhibits the reaction [[Arsenic Trioxide results in increased expression of ESR1 protein] which results in increased expression of TFF1 mRNA]; afimoxifene inhibits the reaction [Arsenic Trioxide results in increased expression of TFF1 mRNA]; afimoxifene inhibits the reaction [deoxynivalenol results in increased expression of TFF1 mRNA]; afimoxifene inhibits the reaction [Estradiol results in increased expression of TFF1 mRNA]; afimoxifene inhibits the reaction [Estrogens results in increased expression of TFF1 mRNA]; afimoxifene promotes the reaction [ESR1 protein binds to TFF1 promoter]; afimoxifene promotes the reaction [GPS2 protein binds to TFF1 promoter]; afimoxifene promotes the reaction [HDAC3 protein binds to TFF1 promoter]; afimoxifene promotes the reaction [NCOR1 protein binds to TFF1 promoter]; methylselenic acid inhibits the reaction [afimoxifene results in increased expression of TFF1 mRNA]; SU 6656 inhibits the reaction [afimoxifene results in increased expression of TFF1 mRNA]

PMID:14617632 PMID:15072547 PMID:15528270 PMID:16093440 PMID:16514628 More...

NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597

G

transferrin receptor

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of TFRC mRNA]

NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257

G

transforming growth factor, beta 3

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of TGFB3 mRNA]

NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564

G

thrombospondin 2

decreases expression

afimoxifene results in decreased expression of THBS2 mRNA

NCBI chr 1:55,670,394...55,699,789
Ensembl chr 1:55,670,394...55,699,789

G

THO complex subunit 2-like

decreases expression

afimoxifene results in decreased expression of THOC2L mRNA

NCBI chr14:5,197,093...5,234,960
Ensembl chr14:5,197,003...5,235,453

G

translocase of inner mitochondrial membrane 23

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of TIMM23 mRNA]

NCBI chr16:7,410,308...7,436,392
Ensembl chr16:7,409,688...7,436,379

G

timeless interacting protein

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of TIPIN mRNA]

NCBI chr 8:64,780,813...64,801,358
Ensembl chr 8:64,780,828...64,801,352

G

toll-like receptor 2

increases expression

afimoxifene results in increased expression of TLR2 mRNA

NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630

G

transmembrane 4 L six family member 1

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of TM4SF1 mRNA]

NCBI chr 2:141,456,950...141,466,146
Ensembl chr 2:141,453,310...141,466,146

G

transmembrane 7 superfamily member 2

increases expression

afimoxifene results in increased expression of TM7SF2 mRNA

NCBI chr 1:203,355,930...203,360,287
Ensembl chr 1:203,355,931...203,360,270

G

transmembrane p24 trafficking protein family member 8

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of TMED8 mRNA]

NCBI chr 6:106,806,973...106,841,271
Ensembl chr 6:106,810,420...106,843,216

G

transmembrane protein with EGF-like and two follistatin-like domains 1

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of TMEFF1 mRNA]

NCBI chr 5:62,910,740...62,996,494
Ensembl chr 5:62,910,740...62,996,493

G

thymopoietin

decreases expression

afimoxifene results in decreased expression of TMPO mRNA

NCBI chr 7:25,642,752...25,667,756
Ensembl chr 7:25,586,725...25,667,727

G

tumor necrosis factor

multiple interactions
increases expression

GPER1 protein affects the reaction [afimoxifene results in increased expression of TNF mRNA]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF alpha induced protein 3

multiple interactions
increases expression

GPER1 protein affects the reaction [afimoxifene results in increased expression of TNFAIP3 mRNA]

NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282

G

transportin 1

decreases expression

afimoxifene results in decreased expression of TNPO1 mRNA

NCBI chr 2:30,207,529...30,300,162
Ensembl chr 2:30,211,510...30,300,375

G

translocase of outer mitochondrial membrane 40

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of TOMM40 mRNA]

NCBI chr 1:79,358,781...79,370,882
Ensembl chr 1:79,358,786...79,370,915

G

DNA topoisomerase I

decreases expression

afimoxifene results in decreased expression of TOP1 mRNA

NCBI chr 3:149,293,469...149,376,618
Ensembl chr 3:149,293,403...149,376,623

G

DNA topoisomerase II beta

decreases expression

afimoxifene results in decreased expression of TOP2B mRNA

NCBI chr15:9,051,340...9,111,721
Ensembl chr15:9,051,341...9,112,085

G

tumor protein p53 inducible nuclear protein 1

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of TP53INP1 mRNA]

NCBI chr 5:24,253,986...24,272,250
Ensembl chr 5:24,260,568...24,267,968

G

Tp53 tumor protein p53 regulating kinase A

decreases response to substance

TP53RK results in decreased susceptibility to afimoxifene

NCBI chr 3:154,219,672...154,224,841
Ensembl chr 3:154,220,851...154,224,328

G

tumor protein p63

increases expression

afimoxifene results in increased expression of TP63 mRNA

NCBI chr11:74,838,858...75,049,764
Ensembl chr11:74,838,859...75,049,398

G

trophoblast glycoprotein

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of TPBG mRNA]

NCBI chr 8:86,793,953...86,797,324
Ensembl chr 8:86,793,749...86,797,741

G

TPD52 like 1

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of TPD52L1 mRNA]

NCBI chr 1:26,172,038...26,290,704
Ensembl chr 1:26,172,170...26,291,109

G

tropomyosin 4

affects response to substance

TPM4 gene affects the susceptibility to afimoxifene

NCBI chr16:17,684,415...17,698,456
Ensembl chr16:17,683,195...17,705,984

G

trafficking kinesin protein 2

decreases expression

afimoxifene results in decreased expression of TRAK2 mRNA

NCBI chr 9:60,348,531...60,414,036
Ensembl chr 9:60,350,012...60,413,996

G

transcriptional regulating factor 1

decreases response to substance

TRERF1 protein results in decreased susceptibility to afimoxifene

NCBI chr 9:13,631,619...13,858,326
Ensembl chr 9:13,634,126...13,857,029

G

tribbles pseudokinase 1

decreases response to substance

TRIB1 results in decreased susceptibility to afimoxifene

NCBI chr 7:91,206,579...91,213,126
Ensembl chr 7:91,206,579...91,214,731

G

tripartite motif-containing 25

multiple interactions
increases expression

afimoxifene inhibits the reaction [Estradiol results in increased expression of TRIM25 mRNA]; afimoxifene inhibits the reaction [Estradiol results in increased expression of TRIM25 protein]
afimoxifene results in increased expression of TRIM25 mRNA; afimoxifene results in increased expression of TRIM25 protein

NCBI chr10:73,812,818...73,831,271
Ensembl chr10:73,812,818...73,831,257

G

tRNA methyltransferase 1

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of TRMT1 mRNA]

NCBI chr19:23,456,756...23,471,581
Ensembl chr19:23,456,756...23,466,956

G

TSC22 domain family, member 1

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of TSC22D1 mRNA]

NCBI chr15:51,750,489...51,850,958
Ensembl chr15:51,749,510...51,850,958

G

tsukushi, small leucine rich proteoglycan

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of TSKU mRNA]

NCBI chr 1:152,660,259...152,671,682
Ensembl chr 1:152,656,693...152,672,588

G

TSPY-like 5

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of TSPYL5 mRNA]

NCBI chr 7:64,881,504...64,885,512
Ensembl chr 7:64,884,225...64,885,457

G

tuftelin 1

multiple interactions
increases expression

GPER1 protein affects the reaction [afimoxifene results in increased expression of TUFT1 mRNA]

NCBI chr 2:182,259,457...182,306,296
Ensembl chr 2:182,260,398...182,306,192

G

twist family bHLH transcription factor 1

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of TWIST1 mRNA]

NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:50,674,678...50,677,653

G

thioredoxin reductase 1

decreases expression

afimoxifene results in decreased expression of TXNRD1 mRNA

NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863

G

ubiquitin-like modifier activating enzyme 3

affects response to substance

UBA3 gene affects the susceptibility to afimoxifene

NCBI chr 4:129,789,526...129,810,707
Ensembl chr 4:129,789,204...129,810,606

G

UDP glucuronosyltransferase family 1 member A1

decreases expression

afimoxifene results in decreased expression of UGT1A1 mRNA

NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

unc-51 like kinase 4

decreases response to substance

ULK4 results in decreased susceptibility to afimoxifene

NCBI chr 8:120,670,879...120,966,026
Ensembl chr 8:120,670,866...120,966,924

G

uridine monophosphate synthetase

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of UMPS mRNA]

NCBI chr11:66,806,107...66,816,520
Ensembl chr11:66,806,045...66,821,903

G

uracil-DNA glycosylase

decreases expression

afimoxifene results in decreased expression of UNG mRNA

NCBI chr12:42,485,276...42,494,217
Ensembl chr12:42,485,276...42,494,206

G

UPF1, RNA helicase and ATPase

increases expression

afimoxifene results in increased expression of UPF1 mRNA

NCBI chr16:19,076,594...19,097,365
Ensembl chr16:19,076,322...19,096,568

G

ubiquitin specific peptidase 32

decreases expression

afimoxifene results in decreased expression of USP32 mRNA

NCBI chr10:69,855,895...70,029,075
Ensembl chr10:69,855,885...70,029,137

G

vitamin D receptor

decreases expression

afimoxifene results in decreased expression of VDR protein

NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677

G

vascular endothelial growth factor A

multiple interactions
increases expression
increases secretion

afimoxifene inhibits the reaction [Estradiol results in increased expression of VEGFA mRNA]; afimoxifene inhibits the reaction [Estradiol results in increased expression of VEGFA protein]
afimoxifene results in increased expression of VEGFA mRNA; afimoxifene results in increased expression of VEGFA protein
afimoxifene results in increased secretion of VEGFA protein

PMID:19148513 PMID:19828145

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

vasoactive intestinal peptide receptor 1

increases expression

afimoxifene results in increased expression of VIPR1 mRNA

NCBI chr 8:121,303,739...121,339,587
Ensembl chr 8:121,310,248...121,339,585

G

VRK serine/threonine kinase 3

decreases response to substance

VRK3 results in decreased susceptibility to afimoxifene

NCBI chr 1:95,243,344...95,270,780
Ensembl chr 1:95,243,364...95,270,780

G

V-set and transmembrane domain containing 4

affects response to substance

VSTM4 gene affects the susceptibility to afimoxifene

NCBI chr16:8,120,336...8,200,272
Ensembl chr16:8,120,336...8,200,269

G

vitronectin

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of VTN mRNA]

NCBI chr10:63,394,732...63,397,812
Ensembl chr10:63,394,719...63,397,810

G

WD repeat domain 4

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of WDR4 mRNA]

NCBI chr20:9,587,205...9,611,434
Ensembl chr20:9,587,207...9,603,581

G

wolframin ER transmembrane glycoprotein

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of WFS1 mRNA]

NCBI chr14:73,810,478...73,834,993
Ensembl chr14:73,810,404...73,835,602

G

WNK lysine deficient protein kinase 2

decreases expression

afimoxifene results in decreased expression of WNK2 mRNA

NCBI chr17:15,503,672...15,612,479
Ensembl chr17:15,504,261...15,612,479

G

Wnt family member 2

increases expression

afimoxifene results in increased expression of WNT2 mRNA

NCBI chr 4:46,328,408...46,374,673
Ensembl chr 4:46,333,998...46,374,402

G

Wnt family member 4

increases expression

afimoxifene results in increased expression of WNT4 mRNA

NCBI chr 5:149,513,573...149,535,415
Ensembl chr 5:149,514,018...149,532,859

G

WW and C2 domain containing 1

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of WWC1 mRNA]

NCBI chr10:20,300,735...20,454,393
Ensembl chr10:20,300,833...20,454,497

G

X-box binding protein 1

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of XBP1 mRNA]

NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693

G

exportin 1

decreases expression

afimoxifene results in decreased expression of XPO1 mRNA

NCBI chr14:97,233,282...97,275,536
Ensembl chr14:97,233,270...97,275,498

G

X-ray repair cross complementing 5

decreases expression

afimoxifene results in decreased expression of XRCC5 mRNA

NCBI chr 9:73,955,216...74,044,020
Ensembl chr 9:73,955,216...74,044,018

G

yrdC N(6)-threonylcarbamoyltransferase domain containing

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of YRDC mRNA]

NCBI chr 5:137,110,244...137,115,127
Ensembl chr 5:137,110,279...137,115,120

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta

increases expression

afimoxifene results in increased expression of YWHAZ mRNA

NCBI chr 7:67,941,353...67,963,651
Ensembl chr 7:67,940,017...67,963,668

G

zinc finger E-box binding homeobox 1

increases expression

afimoxifene results in increased expression of ZEB1 mRNA

NCBI chr17:51,948,948...52,116,018
Ensembl chr17:51,948,948...52,115,214

G

zinc finger protein 148

increases expression

afimoxifene results in increased expression of ZNF148 mRNA

NCBI chr11:67,276,455...67,385,803
Ensembl chr11:67,281,707...67,385,772

G

zinc finger protein 185

increases expression

afimoxifene results in increased expression of ZNF185 mRNA

NCBI chr X:150,831,869...150,877,652
Ensembl chr X:150,831,862...150,874,810

G

zinc finger protein 217

decreases expression

afimoxifene results in decreased expression of ZNF217 mRNA

NCBI chr 3:158,890,464...158,931,148
Ensembl chr 3:158,892,265...158,913,040

G

zinc finger protein 36

multiple interactions
increases expression

GPER1 protein affects the reaction [afimoxifene results in increased expression of ZFP36 mRNA]

NCBI chr 1:83,669,084...83,671,564
Ensembl chr 1:83,669,084...83,671,564

G

zinc finger protein 467

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of ZNF467 mRNA]

NCBI chr 4:77,385,752...77,394,709
Ensembl chr 4:77,385,758...77,392,229

G

zinc finger protein 703

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in increased expression of ZNF703 mRNA]

NCBI chr16:65,076,507...65,080,677
Ensembl chr16:65,076,507...65,080,677

G

zinc finger protein 704

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of ZNF704 mRNA]

NCBI chr 2:92,171,804...92,356,059
Ensembl chr 2:92,171,496...92,351,282

G

zinc finger protein 821

multiple interactions

afimoxifene inhibits the reaction [Estrogens results in decreased expression of ZNF821 mRNA]

NCBI chr19:37,679,937...37,698,831
Ensembl chr19:37,680,628...37,698,831

G

ZW10 interacting kinetochore protein

decreases expression

afimoxifene results in decreased expression of ZWINT mRNA

NCBI chr20:15,938,157...15,953,997
Ensembl chr20:15,938,157...15,953,957

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19922
role	19894
biological role	19864
biochemical role	19596
metabolite	19558
afimoxifene	619
Path 2
Term	Annotations
CHEBI ontology	19922
subatomic particle	19892
composite particle	19892
hadron	19920
baryon	19892
nucleon	19920
atomic nucleus	19892
atom	19892
main group element atom	19866
main group molecular entity	19838
s-block molecular entity	19698
hydrogen molecular entity	19679
hydrides	19181
inorganic hydride	18192
pnictogen hydride	18157
nitrogen hydride	18070
azane	17873
ammonia	17898
organic amino compound	17898
tertiary amino compound	10158
tamoxifen	3272
afimoxifene	619

paths to the root