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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:desogestrel
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Accession:CHEBI:4453 term browser browse the term
Definition:A terminal acetylenic compound that has formula C22H30O.
Synonyms:exact_synonym: 17alpha-ethynyl-11-methylidene-18a-homo-estr-4-en-17beta-ol
 related_synonym: 13-Ethyl-11-methylene-18,19-dinor-17alpha-pregn-4-en-20-yn-17-ol;   Cerazette;   Formula=C22H30O;   InChI=1S/C22H30O/c1-4-21-14-15(3)20-17-9-7-6-8-16(17)10-11-18(20)19(21)12-13-22(21,23)5-2/h2,8,17-20,23H,3-4,6-7,9-14H2,1H3/t17-,18-,19-,20+,21-,22-/m0/s1;   InChIKey=RPLCPCMSCLEKRS-BPIQYHPVSA-N;   SMILES=[H][C@]12CCCC=C1CC[C@@]1([H])[C@]3([H])CC[C@@](O)(C#C)[C@@]3(CC)CC(=C)[C@]21[H];   desogestrelum
 xref: Beilstein:5094648;   CAS:54024-22-5;   DrugBank:DB00304;   Drug_Central:818;   KEGG:C07629;   KEGG:D02367;   LIPID_MAPS_instance:LMST02030104
 xref_mesh: MESH:D017135
 xref: Patent:DE2361120;   Patent:US3927046;   Wikipedia:Desogestrel


show annotations for term's descendants           Sort by:
desogestrel term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity ISO Desogestrel results in decreased activity of AKR1C3 protein CTD PMID:21182831 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G Apoe apolipoprotein E multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of APOE mRNA CTD PMID:18160741 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G Cat catalase multiple interactions ISO [Ethinyl Estradiol co-treated with Desogestrel] results in decreased activity of CAT protein CTD PMID:17541152 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccn5 cellular communication network factor 5 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of CCN5 mRNA CTD PMID:18160741 NCBI chr 3:152,491,247...152,502,639
Ensembl chr 3:152,491,220...152,502,636 		JBrowse link
G Cpb2 carboxypeptidase B2 increases activity ISO Desogestrel results in increased activity of CPB2 protein CTD PMID:11301170 NCBI chr15:50,557,722...50,606,569
Ensembl chr15:50,557,717...50,606,556 		JBrowse link
G Crp C-reactive protein multiple interactions ISO [Ethinyl Estradiol co-treated with Desogestrel] results in increased expression of CRP protein; Simvastatin inhibits the reaction [[Ethinyl Estradiol co-treated with Desogestrel] results in increased expression of CRP protein] CTD PMID:17105841 NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Cst9l cystatin 9-like multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in increased expression of CST9L mRNA CTD PMID:18160741 NCBI chr 3:136,288,093...136,290,906
Ensembl chr 3:136,288,093...136,290,906 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of CYP11A1 mRNA CTD PMID:18160741 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of CYP17A1 mRNA CTD PMID:18160741 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO Desogestrel results in decreased activity of CYP1A2 protein CTD PMID:18816299 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Ddr1 discoidin domain receptor tyrosine kinase 1 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in increased expression of DDR1 mRNA CTD PMID:18160741 NCBI chr20:3,042,494...3,064,442
Ensembl chr20:3,044,320...3,064,468 		JBrowse link
G Dhcr24 24-dehydrocholesterol reductase multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of DHCR24 mRNA CTD PMID:18160741 NCBI chr 5:121,344,552...121,371,124
Ensembl chr 5:121,344,575...121,371,137 		JBrowse link
G Dpep3 dipeptidase 3 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of DPEP3 mRNA CTD PMID:18160741 NCBI chr19:33,868,229...33,876,609
Ensembl chr19:33,868,242...33,873,896 		JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of HMGCS2 mRNA CTD PMID:18160741 NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130 		JBrowse link
G Insl3 insulin-like 3 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of INSL3 mRNA CTD PMID:18160741 NCBI chr16:18,398,682...18,400,566
Ensembl chr16:18,384,829...18,400,560 		JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions
increases expression		 ISO [Desogestrel co-treated with Ethinyl Estradiol] results in increased expression of LDLR protein
Desogestrel results in increased expression of LDLR protein		 CTD PMID:17900441 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580 		JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions ISO [Ethinyl Estradiol co-treated with Desogestrel] results in decreased expression of LHB protein; Simvastatin promotes the reaction [[Ethinyl Estradiol co-treated with Desogestrel] results in decreased expression of LHB protein] CTD PMID:17105841 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Papss2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of PAPSS2 mRNA CTD PMID:18160741 NCBI chr 1:230,454,314...230,539,332
Ensembl chr 1:230,454,426...230,539,331 		JBrowse link
G Pgr progesterone receptor multiple interactions ISO Desogestrel binds to and affects the activity of PGR protein CTD PMID:15697108 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Pgrmc1 progesterone receptor membrane component 1 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of PGRMC1 mRNA CTD PMID:18160741 NCBI chr  X:115,832,865...115,841,060
Ensembl chr  X:115,832,884...115,888,682 		JBrowse link
G Pon1 paraoxonase 1 multiple interactions ISO [Ethinyl Estradiol co-treated with Desogestrel] affects the activity of PON1 protein CTD PMID:17541152 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360 		JBrowse link
G Proc protein C, inactivator of coagulation factors Va and VIIIa decreases activity ISO Desogestrel results in decreased activity of PROC protein CTD PMID:11301170 NCBI chr18:23,764,367...23,774,816
Ensembl chr18:23,764,368...23,775,133 		JBrowse link
G Prok1 prokineticin 1 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of PROK1 mRNA CTD PMID:18160741 NCBI chr 2:194,850,539...194,859,343
Ensembl chr 2:194,853,991...194,859,250 		JBrowse link
G Pros1 protein S affects expression ISO Desogestrel affects the expression of PROS1 protein CTD PMID:11442481 NCBI chr11:230,597...311,288
Ensembl chr11:230,696...311,286 		JBrowse link
G Rhob ras homolog family member B multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of RHOB mRNA CTD PMID:18160741 NCBI chr 6:31,363,752...31,365,926
Ensembl chr 6:31,363,548...31,366,108 		JBrowse link
G Sycp1 synaptonemal complex protein 1 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of SYCP1 mRNA CTD PMID:18160741 NCBI chr 2:190,296,688...190,456,687
Ensembl chr 2:190,296,954...190,456,737 		JBrowse link
G Taf4b TATA-box binding protein associated factor 4b multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of TAF4B mRNA CTD PMID:18160741 NCBI chr18:5,952,737...6,086,408
Ensembl chr18:5,952,769...6,068,307 		JBrowse link
G Tex19.2 testis expressed gene 19.2 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of TEX19 mRNA CTD PMID:18160741 NCBI chr10:106,379,757...106,382,344
Ensembl chr10:106,379,757...106,382,344 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO [Ethinyl Estradiol co-treated with Desogestrel] results in decreased expression of VCAM1 protein; Simvastatin promotes the reaction [[Ethinyl Estradiol co-treated with Desogestrel] results in decreased expression of VCAM1 protein] CTD PMID:17105841 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
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  CHEBI ontology 19874
    role 19844
      application 19689
        pharmaceutical 19525
          drug 19525
            reproductive control drug 5516
              contraceptive drug 3669
                desogestrel 29
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  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      carbon group element atom 19751
                        carbon atom 19748
                          organic molecular entity 19748
                            organic molecule 19700
                              organic cyclic compound 19490
                                organic polycyclic compound 17286
                                  steroid 14717
                                    hydroxy steroid 14466
                                      17-hydroxy steroid 14107
                                        17beta-hydroxy steroid 13363
                                          desogestrel 29
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