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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:nitrofurazone
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Accession:CHEBI:44368 term browser browse the term
Definition:A semicarbazone resulting from the formal condensation of semicarbazide with 5-nitrofuraldehyde. A broad spectrum antibacterial drug, although with little activity against Pseudomonas species, it is used as a local application for burns, ulcers, wounds and skin infections.
Synonyms:exact_synonym: 2-[(5-nitro-2-furyl)methylene]hydrazinecarboxamide
 related_synonym: (5-nitro-2-furfurylidenamino)urea;   1-(5-nitro-2-furfurylidene)semicarbazide;   5-Nitro-2-furaldehyde semicarbazone;   5-nitrofuraldehyde semicarbazide;   5-nitrofuran-2-carbaldehyde semicarbazone;   5-nitrofurfural semicarbazone;   Alfucin;   Amifur;   Chemofuran;   Formula=C6H6N4O4;   Furacillin;   Furacin;   Furacinetten;   Furacoccid;   Furaldon;   Furazol W;   Furesol;   InChI=1S/C6H6N4O4/c7-6(11)9-8-3-4-1-2-5(14-4)10(12)13/h1-3H,(H3,7,9,11);   InChIKey=IAIWVQXQOWNYOU-UHFFFAOYSA-N;   Mammex;   Mastofuran;   Monafuracin;   Nifuzon;   SMILES=NC(=O)NN=Cc1ccc(o1)[N+]([O-])=O;   nitrofural;   nitrofuralum
 alt_id: CHEBI:7592
 xref: CAS:59-87-0;   DrugBank:DB00336;   Drug_Central:1950;   HMDB:HMDB0014480;   KEGG:C08042;   KEGG:D00862;   LINCS:LSM-3779
 xref_mesh: MESH:D009583
 xref: PDBeChem:NFZ;   PMID:14703769;   PMID:2137394;   PMID:22355582;   PMID:2292799;   PMID:23957951;   Patent:US2416234;   Patent:US2927110;   Reaxys:86403;   Wikipedia:Nitrofural


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nitrofurazone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccne1 cyclin E1 multiple interactions
increases expression		 EXP Acetylcysteine inhibits the reaction [Nitrofurazone results in increased expression of CCNE1 mRNA] CTD PMID:15945272 NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta affects binding EXP Nitrofurazone binds to GSK3B protein CTD PMID:18222664 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions
increases expression		 EXP Acetylcysteine inhibits the reaction [Nitrofurazone results in increased expression of HRAS mRNA] CTD PMID:15945272 NCBI chr 1:205,712,625...205,729,406
Ensembl chr 1:196,296,263...196,300,615 		JBrowse link
G Ifng interferon gamma multiple interactions ISO [Nitrofurazone co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IFNG mRNA CTD PMID:29594315 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il1b interleukin 1 beta increases expression ISO Nitrofurazone results in increased expression of IL1B mRNA CTD PMID:29594315 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il2 interleukin 2 multiple interactions ISO [Nitrofurazone co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA CTD PMID:29594315 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Iyd iodotyrosine deiodinase multiple interactions ISO Nitrofurazone inhibits the reaction [IYD protein results in increased metabolism of Monoiodotyrosine] CTD PMID:33352258 NCBI chr 1:42,410,099...42,425,414
Ensembl chr 1:40,004,041...40,019,319 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression		 EXP Acetylcysteine inhibits the reaction [Nitrofurazone results in increased expression of JUN mRNA] CTD PMID:15945272 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression EXP Nitrofurazone results in decreased expression of LHB protein CTD PMID:11548123 NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Mir128-1 microRNA 128-1 increases expression EXP Nitrofurazone results in increased expression of MIR128-1 mRNA CTD PMID:32418910 NCBI chr13:42,251,884...42,251,965
Ensembl chr13:39,699,449...39,699,530 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression
multiple interactions		 EXP Nitrofurazone results in increased expression of MYC mRNA
Acetylcysteine inhibits the reaction [Nitrofurazone results in increased expression of MYC mRNA]		 CTD PMID:15945272 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions EXP [Nitrofurazone co-treated with POR protein co-treated with Copper] results in increased abundance of 8-Hydroxy-2'-Deoxyguanosine; Nitrofurazone inhibits the reaction [POR protein results in increased metabolism of Misonidazole] CTD PMID:6802140 PMID:15488632 NCBI chr12:26,587,674...26,655,612
Ensembl chr12:20,951,058...20,999,245 		JBrowse link
G Prl prolactin decreases expression EXP Nitrofurazone results in decreased expression of PRL protein CTD PMID:11548123 NCBI chr17:38,287,355...38,298,234
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Tgfa transforming growth factor alpha increases expression
multiple interactions		 EXP Nitrofurazone results in increased expression of TGFA mRNA
Acetylcysteine inhibits the reaction [Nitrofurazone results in increased expression of TGFA mRNA]		 CTD PMID:15945272 NCBI chr 4:120,175,549...120,258,342
Ensembl chr 4:118,618,269...118,700,894 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 EXP Acetylcysteine inhibits the reaction [Nitrofurazone results in increased expression of TNF mRNA] CTD PMID:15945272 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 increases mutagenesis ISO Nitrofurazone results in increased mutagenesis of TP53 gene CTD PMID:15488632 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19899
    role 19870
      biological role 19868
        antimicrobial agent 18273
          nitrofuran antibiotic 52
            nitrofurazone 16
Path 2
Term Annotations click to browse term
  CHEBI ontology 19899
    subatomic particle 19897
      composite particle 19897
        hadron 19897
          baryon 19897
            nucleon 19897
              atomic nucleus 19897
                atom 19897
                  main group element atom 19836
                    p-block element atom 19836
                      carbon group element atom 19776
                        carbon atom 19772
                          organic molecular entity 19772
                            heteroorganic entity 19537
                              organochalcogen compound 19297
                                organooxygen compound 19215
                                  carbon oxoacid 18693
                                    carboxylic acid 18690
                                      carboacyl group 17730
                                        univalent carboacyl group 17730
                                          carbamoyl group 17575
                                            carboxamide 17575
                                              monocarboxylic acid amide 15750
                                                urea 6237
                                                  ureas 6235
                                                    semicarbazide 68
                                                      semicarbazone 20
                                                        nitrofurazone 16
paths to the root