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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:malachite green cation
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Accession:CHEBI:44107 term browser browse the term
Definition:An iminium ion obtained by dimethylation of the imino group of 4-{[4-(dimethylamino)phenyl](phenyl)methylene}cyclohexa-2,5-dien-1-imine. Used in the form of its chloride salt as a green-coloured dye.
Synonyms:exact_synonym: 4-{[4-(dimethylamino)phenyl](phenyl)methylene}-N,N-dimethylcyclohexa-2,5-dien-1-iminium
 related_synonym: Formula=C23H25N2;   InChI=1S/C23H25N2/c1-24(2)21-14-10-19(11-15-21)23(18-8-6-5-7-9-18)20-12-16-22(17-13-20)25(3)4/h5-17H,1-4H3/q+1;   InChIKey=VFCNQNZNPKRXIT-UHFFFAOYSA-N;   N-(4-{[4-(dimethylamino)phenyl](phenyl)methylidene}cyclohexa-2,5-dien-1-ylidene)-N-methylmethanaminium;   SMILES=CN(C)c1ccc(cc1)C(c1ccccc1)=C1C=CC(C=C1)=[N+](C)C;   malachite green;   malachite green(1+)
 xref: CAS:10309-95-2;   DrugBank:DB03895
 xref_mesh: MESH:C005095
 xref: PDBeChem:MGR;   PMID:21487207;   PMID:22236952;   PMID:22526306;   PMID:23122763;   PMID:23199816;   PMID:23203820;   PMID:23286983;   PMID:23296502;   PMID:23323052;   PMID:23978698;   Reaxys:3558618;   Wikipedia:Malachite_green


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malachite green cation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bche butyrylcholinesterase decreases activity ISO malachite green results in decreased activity of BCHE protein CTD PMID:16036213 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
G Ccnb1 cyclin B1 multiple interactions EXP [Diethylnitrosamine co-treated with malachite green] results in increased expression of CCNB1 mRNA; [Diethylnitrosamine co-treated with malachite green] results in increased expression of CCNB1 protein CTD PMID:12616621 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions EXP [Diethylnitrosamine co-treated with malachite green] results in increased expression of CCND1 mRNA; [Diethylnitrosamine co-treated with malachite green] results in increased expression of CCND1 protein; malachite green promotes the reaction [Diethylnitrosamine results in increased expression of CCND1 protein] CTD PMID:10906429 PMID:12616621 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccne1 cyclin E1 multiple interactions EXP malachite green promotes the reaction [Diethylnitrosamine results in increased expression of CCNE1 protein] CTD PMID:10906429 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions EXP [Diethylnitrosamine co-treated with malachite green] results in increased expression of CDK1 mRNA; [Diethylnitrosamine co-treated with malachite green] results in increased expression of CDK1 protein CTD PMID:12616621 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions EXP [Diethylnitrosamine co-treated with malachite green] results in increased expression of CDK4 mRNA; [Diethylnitrosamine co-treated with malachite green] results in increased expression of CDK4 protein CTD PMID:12616621 NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Kcna3 potassium voltage-gated channel subfamily A member 3 decreases activity
multiple interactions		 ISO malachite green results in decreased activity of KCNA3 protein
[malachite green results in decreased activity of KCNA3 protein] which results in decreased import of Thallium		 CTD PMID:21362439 NCBI chr 2:194,632,106...194,634,059
Ensembl chr 2:194,632,196...194,650,138 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity
multiple interactions		 ISO malachite green results in decreased activity of KCNH2 protein
[malachite green results in decreased activity of KCNH2 protein] which results in decreased import of Thallium		 CTD PMID:21362439 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Khnyn KH and NYN domain containing affects response to substance ISO KHNYN gene SNP affects the susceptibility to malachite green CTD PMID:25622337 NCBI chr15:29,365,399...29,379,650
Ensembl chr15:29,365,260...29,376,967 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP [Diethylnitrosamine co-treated with malachite green] results in increased expression of PCNA protein; malachite green promotes the reaction [Diethylnitrosamine results in increased expression of PCNA protein] CTD PMID:10906429 PMID:11831363 PMID:12616621 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Rnf150 ring finger protein 150 affects response to substance ISO RNF150 gene SNP affects the susceptibility to malachite green CTD PMID:25622337 NCBI chr19:25,006,978...25,229,273
Ensembl chr19:25,006,611...25,228,678 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      application 19689
        pharmaceutical 19525
          drug 19525
            antifungal drug 5946
              malachite green cation 11
                4-(21-amino-4,9,12-trioxo-16,19-dioxa-5,8,13-triazahenicos-1-yloxy)-malachite green cation 0
                malachite green 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      p-block molecular entity 19811
                        carbon group molecular entity 19751
                          organic molecular entity 19748
                            organic ion 11443
                              organic cation 8954
                                iminium ion 98
                                  malachite green cation 11
                                    4-(21-amino-4,9,12-trioxo-16,19-dioxa-5,8,13-triazahenicos-1-yloxy)-malachite green cation 0
                                    malachite green 0
paths to the root