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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:(S)-fenfluramine
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Accession:CHEBI:439329 term browser browse the term
Definition:The S-enantiomer of fenfluramine. It stimulates the release of serotonin and selectively inhibits its reuptake, but unlike fenfluramine it does not possess catecholamine agonist activity. It was formerly given by mouth as the hydrochloride in the treatment of obesity, but, like fenfluramine, was withdrawn wolrdwide following reports of valvular heart defects.
Synonyms:exact_synonym: (2S)-N-ethyl-1-[3-(trifluoromethyl)phenyl]propan-2-amine
 related_synonym: (+)-fenfluramine;   (S)-N-ethyl-1-[3-(trifluoromethyl)phenyl]propan-2-amine;   Formula=C12H16F3N;   InChI=1S/C12H16F3N/c1-3-16-9(2)7-10-5-4-6-11(8-10)12(13,14)15/h4-6,8-9,16H,3,7H2,1-2H3/t9-/m0/s1;   InChIKey=DBGIVFWFUFKIQN-VIFPVBQESA-N;   SMILES=CCN[C@@H](C)Cc1cccc(c1)C(F)(F)F;   d-N-ethyl-alpha-methyl-m-trifluoromethylphenethylamine;   dexfenfluramina;   dexfenfluramine;   dexfenfluraminum;   dextrofenfluramine
 xref: Beilstein:4783710;   CAS:3239-44-9;   DrugBank:DB01191;   Drug_Central:832;   KEGG:D07805;   LINCS:LSM-5685
 xref_mesh: MESH:D020372
 xref: PMID:16257207;   Patent:US3198834
 cyclic_relationship: is_enantiomer_of CHEBI:521051



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(S)-fenfluramine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Dexfenfluramine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268 JBrowse link
G Slc6a4 solute carrier family 6 member 4 affects activity ISO Dexfenfluramine affects the activity of SLC6A4 protein CTD PMID:18506000 NCBI chr10:62,322,688...62,357,060 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19899
    role 19870
      biological role 19868
        pharmacological role 19105
          neurotransmitter agent 16812
            serotonergic drug 4389
              serotonergic agonist 1023
                (S)-fenfluramine 2
                  (S)-fenfluramine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19899
    subatomic particle 19897
      composite particle 19897
        hadron 19897
          baryon 19897
            nucleon 19897
              atomic nucleus 19897
                atom 19897
                  main group element atom 19836
                    main group molecular entity 19836
                      s-block molecular entity 19670
                        hydrogen molecular entity 19652
                          hydrides 19162
                            organic hydride 18715
                              organic fundamental parent 18715
                                hydrocarbon 18462
                                  halohydrocarbon 15877
                                    haloalkane 12913
                                      fluoroalkane 9232
                                        fluoromethanes 6776
                                          tetrafluoromethane 6776
                                            trifluoromethyl group 6776
                                              (trifluoromethyl)benzenes 6776
                                                fenfluramine 42
                                                  (S)-fenfluramine 2
                                                    (S)-fenfluramine hydrochloride 0
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