The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
A naturally occurring norditerpenoid alkaloid that is isolated from several species of Delphinium. It is a highly potent and selective antagonist of alpha7 nicotinic acetylcholine receptors (IC50 = 2 nM).
AKT1 mutant form inhibits the reaction [methyllycaconitine results in increased expression of SRR protein]; methyllycaconitine inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of and results in increased activity of AKT1 protein] methyllycaconitine results in increased phosphorylation of AKT1 protein methyllycaconitine inhibits the reaction [Tropisetron inhibits the reaction [3-nitropropionic acid results in decreased phosphorylation of AKT1 protein]]
methyllycaconitine inhibits the reaction [Galantamine inhibits the reaction [APP protein modified form results in decreased expression of CHRNA7 protein]]; methyllycaconitine inhibits the reaction [N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide inhibits the reaction [APP protein modified form results in decreased expression of CHRNA7 protein]] methyllycaconitine results in decreased secretion of APP protein [APP protein co-treated with methyllycaconitine] results in decreased secretion of APP protein
methyllycaconitine inhibits the reaction [Tropisetron inhibits the reaction [3-nitropropionic acid results in increased expression of CASP3 protein]]; methyllycaconitine inhibits the reaction [Tropisetron inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP3 protein]]
methyllycaconitine inhibits the reaction [Varenicline results in increased expression of CD36 mRNA]; methyllycaconitine inhibits the reaction [Varenicline results in increased expression of CD36 protein]
Carbachol inhibits the reaction [methyllycaconitine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]]; methyllycaconitine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; methyllycaconitine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; methyllycaconitine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] methyllycaconitine affects the activity of CHRNA4 protein methyllycaconitine affects binding to Chrna4 protein; methyllycaconitine competes with [Epibatidine binds to Chrna4 protein]
[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased abundance of Epinephrine]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased expression of DBH mRNA]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased expression of TH mRNA]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which results in decreased expression of ITGA2B mRNA; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which results in decreased expression of ITGA2B protein; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which results in decreased expression of ITGB3 mRNA; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which results in decreased expression of ITGB3 protein; [methyllycaconitine binds to and results in increased activity of CHRNA7 protein] which results in increased transport of Calcium; methyllycaconitine binds to and results in decreased activity of CHRNA7 protein; methyllycaconitine binds to and results in increased activity of CHRNA7 protein; methyllycaconitine inhibits the reaction [[[1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea affects the activity of CHRNA7 protein] co-treated with [PNU-282987 binds to and results in increased activity of CHRNA7 protein]] results in increased uptake of Calcium]; methyllycaconitine inhibits the reaction [Bungarotoxins binds to CHRNA7 protein]; methyllycaconitine inhibits the reaction [Choline results in increased activity of CHRNA7 protein]; methyllycaconitine inhibits the reaction [desnitroimidacloprid results in increased activity of CHRNA7 protein]; methyllycaconitine inhibits the reaction [epibatidine binds to CHRNA7 protein]; methyllycaconitine inhibits the reaction [Nicotine binds to and results in increased activity of CHRNA7 protein]; methyllycaconitine inhibits the reaction [PNU-282987 binds to and results in increased activity of CHRNA7 protein]; methyllycaconitine inhibits the reaction [pozanicline binds to and results in increased activity of CHRNA7 protein]; methyllycaconitine promotes the reaction [[Nicotine results in increased activity of CHRNA7 protein] which results in increased transport of Calcium] methyllycaconitine analog binds to CHRNA7 protein; methyllycaconitine binds to CHRNA7 protein [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which affects the susceptibility to Nicotine; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which results in decreased susceptibility to bis(12)-hupyridone; methyllycaconitine binds to and results in decreased activity of CHRNA7 protein; methyllycaconitine inhibits the reaction [[3-(4-hydroxy-2-methoxybenzylidene)anabaseine co-treated with 5-hydroxyindole] results in increased activity of CHRNA7 protein]; methyllycaconitine inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; methyllycaconitine inhibits the reaction [iodo-alpha-bungarotoxin binds to CHRNA7 protein]; methyllycaconitine inhibits the reaction [Melitten results in increased activity of CHRNA7 protein]; Nicotine inhibits the reaction [methyllycaconitine binds to CHRNA7 protein] [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which results in decreased susceptibility to Nicotine; methyllycaconitine binds to and results in decreased activity of CHRNA7 protein; methyllycaconitine inhibits the reaction [Galantamine inhibits the reaction [APP protein modified form results in decreased expression of CHRNA7 protein]]; methyllycaconitine inhibits the reaction [N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide inhibits the reaction [APP protein modified form results in decreased expression of CHRNA7 protein]] CHRNA7 protein affects the susceptibility to methyllycaconitine
Carbachol inhibits the reaction [methyllycaconitine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]]; methyllycaconitine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; methyllycaconitine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; methyllycaconitine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] methyllycaconitine affects binding to Chrnb2 protein; methyllycaconitine competes with [Epibatidine binds to Chrnb2 protein]
[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased expression of DBH mRNA]
methyllycaconitine inhibits the reaction [N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide inhibits the reaction [Estradiol affects the expression of IL1B mRNA]] methyllycaconitine inhibits the reaction [Tropisetron inhibits the reaction [3-nitropropionic acid results in increased expression of IL1B protein]]
methyllycaconitine affects the reaction [Nicotine results in increased expression of IL1R1 mRNA]; methyllycaconitine affects the reaction [Nicotine results in increased expression of IL1R1 protein]
[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which results in decreased expression of ITGA2B mRNA; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which results in decreased expression of ITGA2B protein
methyllycaconitine inhibits the reaction [4-naphthalene-1-yl-3a,4,5,9b-tetrahydro-3-H-cyclopenta(c)quinoline-8-sulfonic acid amide inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of ITGAM mRNA]]
[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which results in decreased expression of ITGB3 mRNA; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which results in decreased expression of ITGB3 protein
methyllycaconitine inhibits the reaction [Tropisetron inhibits the reaction [3-nitropropionic acid results in increased phosphorylation of JAK2 protein]]
[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; MAPK1 mutant form inhibits the reaction [methyllycaconitine results in increased expression of SRR protein]; methyllycaconitine inhibits the reaction [Varenicline results in increased phosphorylation of MAPK1 protein] methyllycaconitine results in increased phosphorylation of MAPK1 protein
[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; MAPK3 mutant form inhibits the reaction [methyllycaconitine results in increased expression of SRR protein]; methyllycaconitine inhibits the reaction [Varenicline results in increased phosphorylation of MAPK3 protein] methyllycaconitine results in increased phosphorylation of MAPK3 protein
methyllycaconitine results in increased phosphorylation of MTOR protein MTOR mutant form inhibits the reaction [methyllycaconitine results in increased expression of SRR protein]
methyllycaconitine analog inhibits the reaction [Nicotine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [RELA protein binds to NFKB1 protein]]]
methyllycaconitine inhibits the reaction [4-naphthalene-1-yl-3a,4,5,9b-tetrahydro-3-H-cyclopenta(c)quinoline-8-sulfonic acid amide inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NFKBIA mRNA]]
methyllycaconitine inhibits the reaction [Varenicline results in increased expression of OLR1 mRNA]; methyllycaconitine inhibits the reaction [Varenicline results in increased expression of OLR1 protein]
methyllycaconitine inhibits the reaction [Varenicline results in increased phosphorylation of RELA protein] methyllycaconitine analog inhibits the reaction [Nicotine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [RELA protein binds to NFKB1 protein]]]; methyllycaconitine inhibits the reaction [Tropisetron inhibits the reaction [3-nitropropionic acid results in increased phosphorylation of RELA protein]]
methyllycaconitine inhibits the reaction [SLURP1 protein results in increased abundance of Acetylcholine]; methyllycaconitine inhibits the reaction [SLURP1 protein results in increased expression of CHAT]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [methyllycaconitine results in increased expression of SRR protein]; [methyllycaconitine co-treated with Egtazic Acid] results in increased expression of SRR protein; AKT1 mutant form inhibits the reaction [methyllycaconitine results in increased expression of SRR protein]; Cycloheximide inhibits the reaction [methyllycaconitine results in increased expression of SRR protein]; MAPK1 mutant form inhibits the reaction [methyllycaconitine results in increased expression of SRR protein]; MAPK3 mutant form inhibits the reaction [methyllycaconitine results in increased expression of SRR protein]; MTOR mutant form inhibits the reaction [methyllycaconitine results in increased expression of SRR protein]; Sirolimus inhibits the reaction [methyllycaconitine results in increased expression of SRR protein]; U 0126 inhibits the reaction [methyllycaconitine results in increased expression of SRR protein] [methyllycaconitine co-treated with Egtazic Acid] results in increased expression of SRR protein; Cycloheximide inhibits the reaction [methyllycaconitine results in increased expression of SRR protein]
[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein] methyllycaconitine results in decreased phosphorylation of STAT3 protein methyllycaconitine inhibits the reaction [[Nicotine co-treated with Butylhydroxybutylnitrosamine] results in increased expression of STAT3 protein modified form]
methyllycaconitine inhibits the reaction [Nicotine results in increased expression of TACR1 mRNA]; methyllycaconitine inhibits the reaction [Nicotine results in increased expression of TACR1 protein]
[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased expression of TH mRNA]
methyllycaconitine inhibits the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF mRNA]] methyllycaconitine results in increased expression of TNF protein methyllycaconitine inhibits the reaction [Tropisetron inhibits the reaction [3-nitropropionic acid results in increased expression of TNF protein]]
methyllycaconitine inhibits the reaction [Nicotine results in increased expression of TRPV1 mRNA]; methyllycaconitine inhibits the reaction [Nicotine results in increased expression of TRPV1 protein]
methyllycaconitine inhibits the reaction [Nicotine inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TXN1 protein]]; methyllycaconitine inhibits the reaction [Nicotine results in increased expression of TXN1 protein]
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