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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:indoxyl sulfate
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Accession:CHEBI:43355 term browser browse the term
Definition:An aryl sulfate that is indoxyl in which the hydroxyl hydrogen is substituted by a sulfo group.
Synonyms:related_synonym: 1H-Indol-3-yl hydrogen sulfate;   3-Indoxyl sulfate;   3-Indoxylsulfuric acid;   3-indolyl hydrogen sulfate;   3-indolyl sulfate;   Formula=C8H7NO4S;   InChI=1S/C8H7NO4S/c10-14(11,12)13-8-5-9-7-4-2-1-3-6(7)8/h1-5,9H,(H,10,11,12);   InChIKey=BXFFHSIDQOFMLE-UHFFFAOYSA-N;   Indican;   Indol-3-yl sulfate;   Indoxyl sulfic acid;   Indoxylsulfuric acid;   SMILES=OS(=O)(=O)Oc1c[nH]c2ccccc12;   indol-3-yl hydrogen sulfate;   indol-3-yl sulphate;   indoxyl sulphate;   indoxyl-3-sulphate
 xref: CAS:487-94-5;   HMDB:HMDB0000682
 xref_mesh: MESH:D007200
 xref: PDBeChem:IOS;   PMID:17190852;   PMID:22056374;   PMID:22200421;   PMID:22200422;   PMID:22200425;   PMID:22200426;   PMID:22213462;   PMID:22231736;   PMID:22237753;   PMID:22318422;   PMID:22326498;   PMID:22389425;   PMID:22447217;   PMID:22483453;   PMID:22490877;   PMID:22513409;   Reaxys:188887
 cyclic_relationship: is_conjugate_acid_of CHEBI:144643


show annotations for term's descendants           Sort by:
indoxyl sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc4 ATP binding cassette subfamily C member 4 multiple interactions ISO Indican inhibits the reaction [ABCC4 protein results in increased export of Methotrexate] CTD PMID:21483698 NCBI chr15:101,948,387...102,182,912
Ensembl chr15:101,949,433...102,181,375 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO Indican inhibits the reaction [ABCG2 protein results in increased export of estrone sulfate] CTD PMID:21483698 NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:89,005,969...89,132,493 		JBrowse link
G Ace angiotensin I converting enzyme increases expression EXP Indican results in increased expression of ACE mRNA CTD PMID:25056788 NCBI chr10:91,410,129...91,430,246
Ensembl chr10:91,409,819...91,430,942 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
increases expression
increases activity
increases expression
increases binding
affects localization
increases localization 		ISO
EXP 		AHR protein promotes the reaction [Indican results in increased expression of NPPA mRNA]; AHR protein promotes the reaction [Indican results in increased expression of NPPB mRNA]; Flavones inhibits the reaction [Indican results in increased activity of AHR protein]; Indican binds to and results in increased activity of AHR protein; N-(2-(3H-indol-3-yl)ethyl)-9-isopropyl-2-(5-methyl-3-pyridyl)purin-6-amine inhibits the reaction [Indican results in increased expression of AHR mRNA]
Indican promotes the reaction [[AHR protein binds to ARNT protein] which binds to CCL20 promoter]
indoxyl sulfate increases expression of mRNA, protein in rat cultured cardiomyocyte cells and mouse heart
indoxyl sulfate increases DNA promoter binding in rat cultured cardiomyocyte cells
indoxyl sulfate affects localization in rat cultured cardiomyocyte cells
indoxyl sulfate increases expression of protein in rat kidney
indoxyl sulfate increases expression of mRNA, protein in HK-2 human kidney proximal tubule cell line
Indican results in increased localization of AHR protein 		CTD
RGD		 PMID:20000589 PMID:21493753 PMID:23639249 PMID:26259605 PMID:38670245 More... RGD:401793746, RGD:401793746, RGD:401793746, RGD:401793752, RGD:401793752 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901 		JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor increases expression EXP
ISO 		Indican results in increased expression of AHRR protein CTD PMID:38670245 NCBI chr 1:30,822,219...30,917,251
Ensembl chr 1:30,810,866...30,952,866 		JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions ISO Indican promotes the reaction [[AHR protein binds to ARNT protein] which binds to CCL20 promoter] CTD PMID:26259605 NCBI chr 2:185,686,703...185,745,546
Ensembl chr 2:185,680,683...185,745,546 		JBrowse link
G Casp3 caspase 3 increases cleavage EXP Indican results in increased cleavage of CASP3 protein CTD PMID:25056788 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression
increases expression
multiple interactions 		ISO
EXP 		Indican results in increased expression of CCL2 mRNA; Indican results in increased expression of CCL2 protein
indoxyl sulfate increases expression of protein in rat kidney
indoxyl sulfate increases expression of mRNA, protein in HK-2 human kidney proximal tubule cell line
HMOX1 protein affects the reaction [Luteolin inhibits the reaction [Indican results in increased expression of CCL2 protein]]; Luteolin inhibits the reaction [Indican results in increased expression of CCL2 mRNA]; Luteolin inhibits the reaction [Indican results in increased expression of CCL2 protein] 		CTD
RGD		 PMID:22056374 PMID:39105397 PMID:29238104 PMID:29238104 RGD:401793752, RGD:401793752 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875 		JBrowse link
G Ccl20 C-C motif chemokine ligand 20 multiple interactions ISO Indican promotes the reaction [[AHR protein binds to ARNT protein] which binds to CCL20 promoter] CTD PMID:26259605 NCBI chr 9:91,837,139...91,839,736
Ensembl chr 9:91,836,946...91,839,736 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions 		ISO Indican results in increased expression of CDKN1A protein
Melatonin inhibits the reaction [Indican results in increased expression of CDKN1A protein]; Melatonin promotes the reaction [Pioglitazone inhibits the reaction [Indican results in increased expression of CDKN1A protein]]; Pioglitazone inhibits the reaction [Indican results in increased expression of CDKN1A protein]; Pioglitazone promotes the reaction [Melatonin inhibits the reaction [Indican results in increased expression of CDKN1A protein]]; PRNP protein promotes the reaction [Melatonin promotes the reaction [Pioglitazone inhibits the reaction [Indican results in increased expression of CDKN1A protein]]]; PRNP protein promotes the reaction [Pioglitazone promotes the reaction [Melatonin inhibits the reaction [Indican results in increased expression of CDKN1A protein]]] 		CTD PMID:29734669 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
increases expression
multiple interactions 		ISO
EXP 		Indican results in increased expression of CYP1A1 mRNA
indoxyl sulfate increases expression of protein in rat kidney
indoxyl sulfate increases expression of mRNA, protein in HK-2 human kidney proximal tubule cell line
Indican results in increased expression of and results in increased activity of CYP1A1 protein 		CTD
RGD		 PMID:20000589 PMID:23639249 PMID:38670245 PMID:29238104 PMID:29238104 RGD:401793752, RGD:401793752 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
multiple interactions 		ISO
EXP 		Indican results in increased expression of CYP1A2 mRNA
Indican results in increased expression of and results in increased activity of CYP1A2 protein 		CTD PMID:20000589 PMID:38670245 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression
increases expression 		ISO
EXP 		Indican results in increased expression of CYP1B1 mRNA
indoxyl sulfate increases expression of mRNA, protein in rat cultured cardiomyocyte cells and mouse heart 		CTD
RGD		 PMID:20000589 PMID:31746392 RGD:401793746 NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression ISO Indican results in decreased expression of CYP7A1 mRNA CTD PMID:30639138 NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:24,174,505...24,184,202 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation
multiple interactions 		ISO Indican results in increased phosphorylation of EIF2S1 protein
Acetylcysteine inhibits the reaction [Indican results in increased phosphorylation of EIF2S1 protein] 		CTD PMID:29380555 NCBI chr 6:103,405,880...103,430,549
Ensembl chr 6:103,405,788...103,431,649 		JBrowse link
G Epas1 endothelial PAS domain protein 1 multiple interactions ISO Indican inhibits the reaction [cobaltous chloride affects the localization of EPAS1 protein] CTD PMID:21863063 NCBI chr 6:13,543,252...13,626,147
Ensembl chr 6:13,544,389...13,624,729 		JBrowse link
G Epo erythropoietin multiple interactions ISO Indican inhibits the reaction [cobaltous chloride results in increased expression of EPO mRNA]; Indican inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA] CTD PMID:21863063 NCBI chr12:24,841,285...24,844,725
Ensembl chr12:24,841,285...24,844,725 		JBrowse link
G F2rl1 F2R like trypsin receptor 1 increases expression
multiple interactions 		ISO Indican results in increased expression of F2RL1 mRNA; Indican results in increased expression of F2RL1 protein
Trypsin Inhibitors inhibits the reaction [Indican results in increased expression of F2RL1 mRNA]; Trypsin Inhibitors inhibits the reaction [Indican results in increased expression of F2RL1 protein] 		CTD PMID:32757783 NCBI chr 2:28,507,003...28,519,954
Ensembl chr 2:28,507,003...28,519,954 		JBrowse link
G Fbxo32 F-box protein 32 multiple interactions
increases expression 		ISO Acetylcysteine inhibits the reaction [Indican results in increased expression of FBXO32 protein]; pyrazolanthrone inhibits the reaction [Indican results in increased expression of FBXO32 protein]
Indican results in increased expression of FBXO32 mRNA; Indican results in increased expression of FBXO32 protein 		CTD PMID:29380555 PMID:30849338 NCBI chr 7:91,620,925...91,654,491
Ensembl chr 7:91,620,925...91,654,491 		JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions
decreases expression 		EXP Indican results in decreased expression of and affects the localization of GJA1 protein; pyrazolanthrone inhibits the reaction [Indican results in decreased expression of and affects the localization of GJA1 protein]; pyrazolanthrone inhibits the reaction [Indican results in decreased expression of GJA1 mRNA]
Indican results in decreased expression of GJA1 mRNA; Indican results in decreased expression of GJA1 protein modified form 		CTD PMID:32045570 NCBI chr20:36,302,490...36,315,010
Ensembl chr20:36,302,352...36,319,689 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO Indican inhibits the reaction [cobaltous chloride affects the localization of HIF1A protein] CTD PMID:21863063 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO [Indican co-treated with Luteolin] results in increased expression of HMOX1 protein; HMOX1 protein affects the reaction [Luteolin inhibits the reaction [Indican results in increased expression of CCL2 protein]]; HMOX1 protein affects the reaction [Luteolin inhibits the reaction [Indican results in increased expression of ICAM1 protein]] CTD PMID:39105397 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Hmox2 heme oxygenase 2 multiple interactions ISO HMOX2 protein affects the reaction [Luteolin inhibits the reaction [Indican results in increased expression of JUN protein]]; HMOX2 protein affects the reaction [Luteolin inhibits the reaction [Indican results in increased expression of RELA protein]] CTD PMID:39105397 NCBI chr10:11,303,512...11,337,640
Ensembl chr10:11,303,512...11,318,800 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO Indican results in increased expression of HSPA5 mRNA CTD PMID:29380555 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790 		JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression
multiple interactions 		ISO Indican results in increased expression of ICAM1 mRNA; Indican results in increased expression of ICAM1 protein
HMOX1 protein affects the reaction [Luteolin inhibits the reaction [Indican results in increased expression of ICAM1 protein]]; KL protein inhibits the reaction [Indican results in increased expression of ICAM1 protein]; Luteolin inhibits the reaction [Indican results in increased expression of ICAM1 mRNA]; Luteolin inhibits the reaction [Indican results in increased expression of ICAM1 protein] 		CTD PMID:22056374 PMID:33458837 PMID:39105397 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions 		ISO Indican results in increased expression of JUN protein
Acetylcysteine inhibits the reaction [Indican results in increased expression of JUN protein]; HMOX2 protein affects the reaction [Luteolin inhibits the reaction [Indican results in increased expression of JUN protein]]; Luteolin inhibits the reaction [Indican results in increased expression of JUN protein] 		CTD PMID:39105397 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285 		JBrowse link
G Kl Klotho multiple interactions
decreases expression 		ISO
EXP 		Acetylcysteine inhibits the reaction [Indican results in decreased expression of KL mRNA]; Acetylcysteine inhibits the reaction [Indican results in decreased expression of KL protein]; isohelenin inhibits the reaction [Indican results in decreased expression of KL mRNA]; isohelenin inhibits the reaction [Indican results in decreased expression of KL protein]; KL protein inhibits the reaction [Indican results in increased expression of ICAM1 protein]; KL protein inhibits the reaction [Indican results in increased expression of VCAM1 protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [Indican results in decreased expression of KL mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Indican results in decreased expression of KL protein]
Indican results in decreased expression of KL mRNA; Indican results in decreased expression of KL protein 		CTD PMID:21389697 PMID:33458837 NCBI chr12:5,326,003...5,367,016
Ensembl chr12:5,325,959...5,367,015 		JBrowse link
G Lepr leptin receptor affects abundance ISO LEPR affects the abundance of Indican CTD PMID:20567778 NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:121,474,099...121,591,215 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases expression
multiple interactions 		ISO Indican results in increased expression of MAP1LC3B protein
Acetylcysteine inhibits the reaction [Indican results in increased expression of MAP1LC3B protein] 		CTD PMID:30849338 NCBI chr19:66,571,631...66,582,270
Ensembl chr19:66,574,407...66,584,358
Ensembl chr16:66,574,407...66,584,358 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation 		ISO
EXP 		Acetylcysteine inhibits the reaction [Indican results in increased phosphorylation of MAPK1 protein]
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Indican results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Indican results in increased phosphorylation of MAPK1 protein]; alizarin inhibits the reaction [Indican results in increased phosphorylation of MAPK1 protein] 		CTD PMID:30849338 PMID:38670245 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions 		ISO Indican results in increased phosphorylation of MAPK3 protein
Acetylcysteine inhibits the reaction [Indican results in increased phosphorylation of MAPK3 protein] 		CTD PMID:30849338 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation 		ISO
EXP 		Indican results in increased expression of and results in increased phosphorylation of MAPK8 protein
Indican results in increased phosphorylation of MAPK8 protein 		CTD PMID:30849338 PMID:32045570 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation EXP Indican results in increased phosphorylation of MAPK9 protein CTD PMID:32045570 NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228 		JBrowse link
G Mas1 MAS1 proto-oncogene, G protein-coupled receptor decreases expression EXP indoxyl sulfate decreases expression of Mas1 protein in rat kidney RGD PMID:24614509 RGD:401793742 NCBI chr 1:50,428,064...50,459,537
Ensembl chr 1:50,425,257...50,500,561 		JBrowse link
G Myh2 myosin heavy chain 2 decreases expression ISO Indican results in decreased expression of MYH2 mRNA CTD PMID:29380555 NCBI chr10:52,355,739...52,382,235
Ensembl chr10:52,355,739...52,382,235 		JBrowse link
G Myh3 myosin heavy chain 3 multiple interactions
decreases expression 		ISO Acetylcysteine inhibits the reaction [Indican results in decreased expression of MYH3 protein] CTD PMID:29380555 NCBI chr10:52,269,185...52,293,000
Ensembl chr10:52,269,185...52,293,000 		JBrowse link
G Myh7 myosin heavy chain 7 increases expression EXP Indican results in increased expression of MYH7 mRNA CTD PMID:25703824 NCBI chr15:32,416,525...32,439,851
Ensembl chr15:32,416,527...32,438,194 		JBrowse link
G Myl9 myosin light chain 9 multiple interactions ISO Indican results in decreased expression of and results in increased phosphorylation of MYL9 protein CTD PMID:30849338 NCBI chr 3:165,742,020...165,748,409
Ensembl chr 3:165,742,046...165,748,410 		JBrowse link
G Myod1 myogenic differentiation 1 decreases expression ISO Indican results in decreased expression of MYOD1 protein CTD PMID:29380555 NCBI chr 1:106,021,161...106,023,871
Ensembl chr 1:106,021,161...106,023,871 		JBrowse link
G Myog myogenin multiple interactions
decreases expression 		ISO Acetylcysteine inhibits the reaction [Indican results in decreased expression of MYOG protein]
Indican results in decreased expression of MYOG mRNA; Indican results in decreased expression of MYOG protein 		CTD PMID:29380555 NCBI chr13:48,297,476...48,300,065
Ensembl chr13:48,297,235...48,300,065 		JBrowse link
G Nox4 NADPH oxidase 4 increases expression ISO Indican results in increased expression of NOX4 mRNA CTD PMID:23325087 NCBI chr 1:150,313,736...150,491,480
Ensembl chr 1:150,313,728...150,491,483 		JBrowse link
G Nppa natriuretic peptide A increases expression
increases expression
multiple interactions 		EXP
ISO 		Indican results in increased expression of NPPA mRNA
indoxyl sulfate increases expression of mRNA in mouse heart
AHR protein promotes the reaction [Indican results in increased expression of NPPA mRNA] 		CTD
RGD		 PMID:25703824 PMID:38670245 PMID:31746392 RGD:401793746 NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:163,712,184...163,713,493 		JBrowse link
G Nppb natriuretic peptide B increases expression
increases expression
multiple interactions 		EXP
ISO 		Indican results in increased expression of NPPB mRNA
indoxyl sulfate increases expression of mRNA in mouse heart
AHR protein promotes the reaction [Indican results in increased expression of NPPB mRNA] 		CTD
RGD		 PMID:25703824 PMID:38670245 PMID:31746392 RGD:401793746 NCBI chr 5:163,699,955...163,701,314
Ensembl chr 5:163,699,839...163,701,310 		JBrowse link
G Prnp prion protein multiple interactions ISO PRNP protein promotes the reaction [Melatonin promotes the reaction [Pioglitazone inhibits the reaction [Indican results in decreased expression of RGN protein]]]; PRNP protein promotes the reaction [Melatonin promotes the reaction [Pioglitazone inhibits the reaction [Indican results in increased expression of CDKN1A protein]]]; PRNP protein promotes the reaction [Pioglitazone promotes the reaction [Melatonin inhibits the reaction [Indican results in decreased expression of RGN protein]]]; PRNP protein promotes the reaction [Pioglitazone promotes the reaction [Melatonin inhibits the reaction [Indican results in increased expression of CDKN1A protein]]] CTD PMID:29734669 NCBI chr 3:139,639,076...139,654,420
Ensembl chr 3:139,630,144...139,658,436 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO
EXP 		Indican results in increased expression of PTGS2 protein CTD PMID:38670245 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases expression 		ISO Acetylcysteine inhibits the reaction [Indican results in increased expression of RELA protein]; HMOX2 protein affects the reaction [Luteolin inhibits the reaction [Indican results in increased expression of RELA protein]]; Luteolin inhibits the reaction [Indican results in increased expression of RELA protein] CTD PMID:39105397 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Ren renin increases expression EXP Indican results in increased expression of REN mRNA CTD PMID:25056788 NCBI chr13:47,348,312...47,359,539
Ensembl chr13:47,348,143...47,359,543 		JBrowse link
G Rgn regucalcin decreases expression
multiple interactions 		ISO Indican results in decreased expression of RGN protein
Melatonin inhibits the reaction [Indican results in decreased expression of RGN protein]; Melatonin promotes the reaction [Pioglitazone inhibits the reaction [Indican results in decreased expression of RGN protein]]; Pioglitazone inhibits the reaction [Indican results in decreased expression of RGN protein]; Pioglitazone promotes the reaction [Melatonin inhibits the reaction [Indican results in decreased expression of RGN protein]]; PRNP protein promotes the reaction [Melatonin promotes the reaction [Pioglitazone inhibits the reaction [Indican results in decreased expression of RGN protein]]]; PRNP protein promotes the reaction [Pioglitazone promotes the reaction [Melatonin inhibits the reaction [Indican results in decreased expression of RGN protein]]] 		CTD PMID:29734669 NCBI chr  X:4,172,537...4,190,112
Ensembl chr  X:4,172,537...4,190,251 		JBrowse link
G Rorc RAR-related orphan receptor C increases expression ISO Indican results in increased expression of RORC mRNA CTD PMID:23639249 NCBI chr 2:184,698,779...184,723,942
Ensembl chr 2:184,698,818...184,724,566 		JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression ISO Indican results in decreased expression of SLC10A1 mRNA CTD PMID:30639138 NCBI chr 6:106,344,319...106,357,944
Ensembl chr 6:106,344,319...106,357,944 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions ISO [Lansoprazole results in decreased activity of SLC22A8 protein] which results in decreased uptake of Indican; [Omeprazole results in decreased activity of SLC22A8 protein] which results in decreased uptake of Indican; [Pantoprazole results in decreased activity of SLC22A8 protein] which results in decreased uptake of Indican CTD PMID:36243147 NCBI chr 1:214,925,506...214,945,516
Ensembl chr 1:214,925,508...214,946,588 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 decreases expression ISO Indican results in decreased expression of SLCO1B3 mRNA CTD PMID:30639138 NCBI chr 4:176,282,577...176,355,557
Ensembl chr 4:176,282,584...176,351,083 		JBrowse link
G Slco3a1 solute carrier organic anion transporter family, member 3a1 multiple interactions ISO Indican promotes the reaction [SLCO3A1 protein results in increased uptake of simvastatin acid] CTD PMID:28887287 NCBI chr 1:137,516,037...137,797,836
Ensembl chr 1:137,505,158...137,797,836 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions
increases phosphorylation 		ISO [AG 1879 results in decreased activity of SRC protein] inhibits the reaction [Indican results in increased phosphorylation of SRC protein]; [AG 1879 results in decreased activity of SRC protein] inhibits the reaction [Indican results in increased phosphorylation of STAT3 protein] CTD PMID:23639249 NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:166,511,985...166,559,462 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO [AG 1879 results in decreased activity of SRC protein] inhibits the reaction [Indican results in increased phosphorylation of STAT3 protein]; Indican results in increased phosphorylation of and results in increased activity of STAT3 protein
indoxyl sulfate increases expression and increases phosphorylation of Stat3 in HK-2 human kidney proximal tubule cell line 		CTD
RGD		 PMID:23639249 PMID:29238104 RGD:401793752 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression EXP
ISO 		indoxyl sulfate increases expression of protein in rat kidney
indoxyl sulfate increases expression of mRNA, protein in HK-2 human kidney proximal tubule cell line 		RGD PMID:29238104 PMID:29238104 RGD:401793752, RGD:401793752 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Ucp2 uncoupling protein 2 multiple interactions
decreases expression
decreases response to substance 		EXP AICA ribonucleotide inhibits the reaction [Indican results in decreased expression of UCP2 mRNA]
UCP2 protein results in decreased susceptibility to Indican 		CTD PMID:25703824 NCBI chr 1:164,251,373...164,257,742
Ensembl chr 1:164,251,373...164,257,743 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression ISO Indican results in increased expression of UGT1A1 mRNA CTD PMID:20000589 NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases expression ISO Indican results in increased expression of UGT1A6 mRNA CTD PMID:20000589 NCBI chr 9:96,195,018...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression
multiple interactions 		ISO Indican results in increased expression of VCAM1 mRNA; Indican results in increased expression of VCAM1 protein
KL protein inhibits the reaction [Indican results in increased expression of VCAM1 protein] 		CTD PMID:22056374 PMID:33458837 NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801 		JBrowse link
G Xbp1 X-box binding protein 1 increases splicing ISO Indican results in increased splicing of XBP1 mRNA CTD PMID:29380555 NCBI chr14:84,604,623...84,609,707
Ensembl chr14:84,604,107...84,609,706 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20873
    role 20805
      chemical role 20383
        catalyst 8405
          sulfuric acid 8355
            sulfuric acid derivative 8355
              organic sulfate 2477
                aryl sulfate 65
                  indoxyl sulfate 61
Path 2
Term Annotations click to browse term
  CHEBI ontology 20873
    subatomic particle 20871
      composite particle 20871
        hadron 20871
          baryon 20871
            nucleon 20871
              atomic nucleus 20871
                atom 20871
                  main group element atom 20794
                    p-block element atom 20794
                      carbon group element atom 20727
                        carbon atom 20722
                          organic molecular entity 20722
                            organic molecule 20666
                              organic cyclic compound 20416
                                organic heterocyclic compound 19388
                                  organic heteropolycyclic compound 18643
                                    organic heterobicyclic compound 17522
                                      benzopyrrole 9847
                                        indoles 9538
                                          hydroxyindoles 185
                                            indoxyl 61
                                              indoxyl sulfate 61
paths to the root