guanidine - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	guanidine	go back to main search page
Accession:	CHEBI:42820	browse the term
Definition:	An aminocarboxamidine, the parent compound of the guanidines.
Synonyms:	related_synonym:	Formula=CH5N3; Gu; H2N-C(=NH)-NH2; InChI=1S/CH5N3/c2-1(3)4/h(H5,2,3,4); InChIKey=ZRALSGWEFCBTJO-UHFFFAOYSA-N; SMILES=NC(N)=N; aminomethanamidine; guanidin; iminourea
	alt_id:	CHEBI:24435; CHEBI:42816
	xref:	Beilstein:506044; CAS:113-00-8; DrugBank:DB00536; Drug_Central:1344; Gmelin:100679
	xref_mesh:	MESH:D019791
	xref:	PDBeChem:GAI; PMID:8070089; Reaxys:506044; Wikipedia:Guanidine
	cyclic_relationship:	is_conjugate_base_of CHEBI:30087

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Genes (757)

guanidine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

albumin

multiple interactions
affects folding
decreases folding

Guanidine affects the folding of [acrylodan binds to ALB protein]; Guanidine inhibits the reaction [prodan binds to ALB protein]
Guanidine affects the folding of ALB protein
Guanidine results in decreased folding of ALB protein

PMID:12044178 PMID:15353599

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

solute carrier family 22 member 16

multiple interactions

Guanidine inhibits the reaction [SLC22A16 protein results in increased uptake of Tetraethylammonium]

NCBI chr20:43,972,808...44,068,447
Ensembl chr20:43,972,836...44,065,019

G

solute carrier family 22 member 3

increases uptake
multiple interactions

SLC22A3 protein results in increased uptake of Guanidine
Guanidine inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]
Guanidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
Guanidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium analog]

PMID:9830022 PMID:10966924

NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612

G

solute carrier family 47 member 1

multiple interactions

Guanidine affects the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637

G

solute carrier family 47 member 2

multiple interactions

Guanidine affects the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904

G

superoxide dismutase 1

decreases folding

Guanidine results in decreased folding of SOD1 protein mutant form

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

(E)-thiamethoxam

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alkaline phosphatase, biomineralization associated

increases activity
multiple interactions

Thiamethoxam results in increased activity of ALPL protein
[fenugreek seed meal results in increased abundance of Polysaccharides] inhibits the reaction [Thiamethoxam results in decreased activity of ALPL protein]

NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446

G

annexin A10

increases expression

Thiamethoxam results in increased expression of ANXA10 mRNA

NCBI chr16:27,738,712...27,805,648
Ensembl chr16:27,738,712...27,805,648

G

androgen receptor

affects binding

Thiamethoxam binds to AR protein

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

arginase 1

decreases expression

Thiamethoxam results in decreased expression of ARG1 mRNA

NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422

G

activating transcription factor 3

increases expression

Thiamethoxam results in increased expression of ATF3 mRNA

NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631

G

BCL2 associated X, apoptosis regulator

increases expression

Thiamethoxam results in increased expression of BAX protein

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

decreases expression

Thiamethoxam results in decreased expression of BCL2 protein

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

BCL6, transcription repressor

decreases expression

Thiamethoxam results in decreased expression of BCL6 mRNA

NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389

G

BTG anti-proliferation factor 1

increases expression

Thiamethoxam results in increased expression of BTG1 mRNA

NCBI chr 7:31,341,391...31,343,649
Ensembl chr 7:31,341,027...31,343,649

G

caspase 3

increases cleavage

Thiamethoxam results in increased cleavage of CASP3 protein

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

catalase

increases expression
decreases expression
decreases activity
multiple interactions

Thiamethoxam results in increased expression of CAT mRNA
Thiamethoxam results in decreased expression of CAT mRNA
Thiamethoxam results in decreased activity of CAT protein
[fenugreek seed meal results in increased abundance of Polysaccharides] inhibits the reaction [Thiamethoxam results in decreased activity of CAT protein]; Plant Extracts inhibits the reaction [Thiamethoxam results in decreased activity of CAT protein]; Silymarin inhibits the reaction [Thiamethoxam results in decreased activity of CAT protein]; Silymarin inhibits the reaction [Thiamethoxam results in decreased expression of CAT mRNA]

PMID:30621503 PMID:33533595 PMID:34181816 PMID:36958429

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 2

increases expression

Thiamethoxam results in increased expression of CCL2 mRNA

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

cholinergic receptor nicotinic beta 2 subunit

multiple interactions

Thiamethoxam results in increased activity of [NACHRALPHA1 protein co-treated with CHRNB2 protein]

NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619

G

cytochrome P450, family 11, subfamily a, polypeptide 1

decreases expression
multiple interactions

Thiamethoxam results in decreased expression of CYP11A1 mRNA
Plant Extracts inhibits the reaction [Thiamethoxam results in decreased expression of CYP11A1 mRNA]

NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338

G

cytochrome P450, family 17, subfamily a, polypeptide 1

decreases expression
multiple interactions

Thiamethoxam results in decreased expression of CYP17A1 mRNA
Plant Extracts inhibits the reaction [Thiamethoxam results in decreased expression of CYP17A1 mRNA]

NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573

G

cytochrome P450, family 19, subfamily a, polypeptide 1

increases expression
multiple interactions
increases activity

Thiamethoxam results in increased expression of CYP19A1 mRNA
Plant Extracts inhibits the reaction [Thiamethoxam results in increased expression of CYP19A1 mRNA]
Thiamethoxam results in increased activity of CYP19A1 protein

PMID:26464060 PMID:28750898 PMID:34181816

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

cytochrome P450, family 2, subfamily C, polypeptide 6

decreases expression

Thiamethoxam results in decreased expression of CYP2C19 protein

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions

[NADP co-treated with CYP3A4 protein] results in increased activity of Thiamethoxam

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450 family 7 subfamily A member 1

decreases expression

Thiamethoxam results in decreased expression of CYP7A1 protein

NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688

G

DNA-damage inducible transcript 3

increases expression

Thiamethoxam results in increased expression of DDIT3 mRNA; Thiamethoxam results in increased expression of DDIT3 protein

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

estrogen receptor 1

affects binding
decreases expression

Thiamethoxam binds to ESR1 protein
Thiamethoxam results in decreased expression of ESR1 protein

PMID:31550567 PMID:33533595

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

forkhead box O3

increases expression

Thiamethoxam results in increased expression of FOXO3 mRNA

NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561

G

follicle stimulating hormone receptor

decreases expression

Thiamethoxam results in decreased expression of FSHR protein

NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785

G

glucose-6-phosphatase catalytic subunit 1

decreases expression

Thiamethoxam results in decreased expression of G6PC1 mRNA

NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804

G

growth arrest and DNA-damage-inducible, beta

decreases expression

Thiamethoxam results in decreased expression of GADD45B mRNA

NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046

G

glutamic-oxaloacetic transaminase 1

increases activity
multiple interactions

Thiamethoxam results in increased activity of GOT1 protein
[fenugreek seed meal results in increased abundance of Polysaccharides] inhibits the reaction [Thiamethoxam results in decreased activity of GOT1 protein]

NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633

G

glutamic--pyruvic transaminase

decreases activity

Thiamethoxam results in decreased activity of GPT protein

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glutathione peroxidase 1

increases expression
decreases expression
decreases activity
multiple interactions

Thiamethoxam results in increased expression of GPX1 mRNA
Thiamethoxam results in decreased expression of GPX1 mRNA
Thiamethoxam results in decreased activity of GPX1 protein
[fenugreek seed meal results in increased abundance of Polysaccharides] inhibits the reaction [Thiamethoxam results in decreased activity of GPX1 protein]; Silymarin inhibits the reaction [Thiamethoxam results in decreased expression of GPX1 mRNA]

PMID:30621503 PMID:33533595 PMID:36958429

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

multiple interactions
decreases expression

Plant Extracts inhibits the reaction [Thiamethoxam results in decreased expression of HSD3B1 mRNA]

NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999

G

heat shock protein family A (Hsp70) member 5

increases expression

Thiamethoxam results in increased expression of HSPA5 mRNA; Thiamethoxam results in increased expression of HSPA5 protein

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

interleukin 1 beta

multiple interactions
increases expression

Silymarin inhibits the reaction [Thiamethoxam results in increased expression of IL1B protein]
Thiamethoxam results in increased expression of IL1B mRNA; Thiamethoxam results in increased expression of IL1B protein

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions
increases expression

Silymarin inhibits the reaction [Thiamethoxam results in increased expression of IL6 mRNA]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

inositol 1,4,5-trisphosphate receptor, type 1

decreases expression

Thiamethoxam results in decreased expression of ITPR1 mRNA

NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491

G

JunB proto-oncogene, AP-1 transcription factor subunit

decreases expression

Thiamethoxam results in decreased expression of JUNB mRNA

NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035

G

lactate dehydrogenase A

increases activity
multiple interactions

Thiamethoxam results in increased activity of LDHA protein
[fenugreek seed meal results in increased abundance of Polysaccharides] inhibits the reaction [Thiamethoxam results in decreased activity of LDHA protein]

NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472

G

luteinizing hormone/choriogonadotropin receptor

decreases expression
multiple interactions
increases expression

Thiamethoxam results in decreased expression of LHCGR protein
Plant Extracts inhibits the reaction [Thiamethoxam results in increased expression of LHCGR mRNA]

PMID:33533595 PMID:34181816

NCBI chr 6:5,661,871...5,728,109
Ensembl chr 6:5,661,871...5,724,521

G

leukocyte specific transcript 1

increases expression

Thiamethoxam results in increased expression of LST1 mRNA

NCBI chr20:3,634,680...3,639,731
Ensembl chr20:3,634,749...3,637,997

G

melanocortin 4 receptor

decreases expression

Thiamethoxam results in decreased expression of MC4R mRNA

NCBI chr18:60,419,832...60,421,719
Ensembl chr18:60,419,832...60,421,719

G

matrix metallopeptidase 7

increases expression

Thiamethoxam results in increased expression of MMP7 mRNA

NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902

G

nitric oxide synthase 2

decreases activity
multiple interactions
increases expression

Thiamethoxam metabolite results in decreased activity of NOS2 protein
Silymarin inhibits the reaction [Thiamethoxam results in increased expression of NOS2 mRNA]
[Thiamethoxam metabolite results in decreased activity of NOS2 protein] which results in increased chemical synthesis of Formaldehyde

PMID:29197058 PMID:36958429

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

phospholipase C, gamma 2

decreases expression

Thiamethoxam results in decreased expression of PLCG2 mRNA

NCBI chr19:45,547,416...45,683,930
Ensembl chr19:45,547,416...45,683,930

G

prion protein

increases expression

Thiamethoxam results in increased expression of PRNP mRNA

NCBI chr 3:119,186,073...119,201,513
Ensembl chr 3:119,177,485...119,203,937

G

prostaglandin-endoperoxide synthase 2

decreases expression

Thiamethoxam results in decreased expression of PTGS2 mRNA

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

parathyroid hormone-like hormone

decreases expression

Thiamethoxam results in decreased expression of PTHLH mRNA

NCBI chr 4:180,188,792...180,199,847
Ensembl chr 4:180,188,792...180,199,847

G

pentraxin 3

increases expression

Thiamethoxam results in increased expression of PTX3 mRNA

NCBI chr 2:150,487,513...150,493,323
Ensembl chr 2:150,487,513...150,493,323

G

scavenger receptor class B, member 1

multiple interactions
decreases expression

Plant Extracts inhibits the reaction [Thiamethoxam results in decreased expression of SCARB1 mRNA]

NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647

G

sestrin 2

increases expression

Thiamethoxam results in increased expression of SESN2 mRNA

NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260

G

solute carrier family 22 member 2

decreases activity

Thiamethoxam results in decreased activity of SLC22A2 protein

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

solute carrier family 7 member 11

increases expression

Thiamethoxam results in increased expression of SLC7A11 mRNA

NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536

G

superoxide dismutase 1

decreases activity
decreases expression
multiple interactions

Thiamethoxam results in decreased activity of SOD1 protein
Thiamethoxam results in decreased expression of SOD1 mRNA
[fenugreek seed meal results in increased abundance of Polysaccharides] inhibits the reaction [Thiamethoxam results in decreased activity of SOD1 protein]; Silymarin inhibits the reaction [Thiamethoxam results in decreased expression of SOD1 mRNA]

PMID:30621503 PMID:36958429

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

steroidogenic acute regulatory protein

decreases expression
multiple interactions

Thiamethoxam results in decreased expression of STAR mRNA
Plant Extracts inhibits the reaction [Thiamethoxam results in decreased expression of STAR mRNA]

NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672

G

stanniocalcin 2

increases expression

Thiamethoxam results in increased expression of STC2 mRNA

NCBI chr10:16,251,046...16,260,815
Ensembl chr10:16,250,853...16,262,973

G

thrombospondin 4

decreases expression

Thiamethoxam results in decreased expression of THBS4 mRNA

NCBI chr 2:23,983,158...24,025,289
Ensembl chr 2:23,983,158...24,026,313

G

thyroid hormone receptor alpha

affects binding

Thiamethoxam binds to THRA protein

NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936

G

tumor necrosis factor

multiple interactions
increases expression

Silymarin inhibits the reaction [Thiamethoxam results in increased expression of TNF mRNA]; Silymarin inhibits the reaction [Thiamethoxam results in increased expression of TNF protein]
Thiamethoxam results in increased expression of TNF mRNA; Thiamethoxam results in increased expression of TNF protein

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

troponin T2, cardiac type

increases secretion
multiple interactions

Thiamethoxam results in increased secretion of TNNT2 protein
fenugreek seed meal inhibits the reaction [Thiamethoxam results in increased secretion of TNNT2 protein]; Polysaccharides inhibits the reaction [Thiamethoxam results in increased secretion of TNNT2 protein]

NCBI chr13:47,267,325...47,285,390
Ensembl chr13:47,267,204...47,285,388

clothianidin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 13

increases expression

clothianidin results in increased expression of ABCA13 mRNA

NCBI chr14:83,873,397...84,376,138
Ensembl chr14:83,873,940...84,375,075

G

ATP binding cassette subfamily B member 6

decreases expression

clothianidin results in decreased expression of ABCB6 mRNA

NCBI chr 9:76,668,554...76,677,263
Ensembl chr 9:76,668,554...76,676,924

G

ATP binding cassette subfamily C member 1

increases expression

clothianidin results in increased expression of ABCC1 mRNA

NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114

G

ATP binding cassette subfamily C member 3

multiple interactions
increases expression

[enilconazole co-treated with clothianidin] results in increased expression of ABCC3 mRNA; [thiacloprid co-treated with clothianidin] results in increased expression of ABCC3 mRNA
clothianidin results in increased expression of ABCC3 mRNA

NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595

G

ATP binding cassette subfamily D member 2

decreases expression

clothianidin results in decreased expression of ABCD2 mRNA

NCBI chr 7:122,263,034...122,311,642
Ensembl chr 7:122,263,032...122,311,642

G

ATP binding cassette subfamily D member 3

decreases expression

clothianidin results in decreased expression of ABCD3 mRNA

NCBI chr 2:209,852,087...209,905,763
Ensembl chr 2:209,852,087...209,906,020

G

ATP binding cassette subfamily G member 1

decreases expression

clothianidin results in decreased expression of ABCG1 mRNA

NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948

G

abhydrolase domain containing 4, N-acyl phospholipase B

decreases expression

clothianidin results in decreased expression of ABHD4 mRNA

NCBI chr15:27,697,384...27,716,013
Ensembl chr15:27,704,113...27,716,966

G

ABI family member 3 binding protein

decreases expression

clothianidin results in decreased expression of ABI3BP mRNA

NCBI chr11:43,912,187...44,128,888
Ensembl chr11:43,913,043...44,128,929

G

acetylcholinesterase

decreases expression

clothianidin results in decreased expression of ACHE mRNA

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

adenylate cyclase 2

increases expression

clothianidin results in increased expression of ADCY2 mRNA

NCBI chr 1:34,375,639...34,822,252
Ensembl chr 1:34,375,895...34,822,236

G

adenylate cyclase 4

decreases expression

clothianidin results in decreased expression of ADCY4 mRNA

NCBI chr15:29,266,280...29,282,153
Ensembl chr15:29,266,287...29,282,108

G

adhesion G protein-coupled receptor B2

decreases expression

clothianidin results in decreased expression of ADGRB2 mRNA

NCBI chr 5:142,299,190...142,362,540
Ensembl chr 5:142,331,329...142,362,540

G

adhesion G protein-coupled receptor F5

decreases expression

clothianidin results in decreased expression of ADGRF5 mRNA

NCBI chr 9:17,517,596...17,624,107
Ensembl chr 9:17,520,009...17,623,968

G

adhesion G protein-coupled receptor G6

decreases expression

clothianidin results in decreased expression of ADGRG6 mRNA

NCBI chr 1:8,812,889...8,954,239
Ensembl chr 1:8,812,904...8,954,123

G

adrenoceptor beta 2

decreases expression

clothianidin results in decreased expression of ADRB2 mRNA

NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512

G

AGBL carboxypeptidase 3

increases expression

clothianidin results in increased expression of AGBL3 mRNA

NCBI chr 4:63,448,789...63,535,538
Ensembl chr 4:63,453,940...63,531,188

G

aldo-keto reductase family 1, member B7

increases expression

clothianidin results in increased expression of AKR1B7 mRNA

NCBI chr 4:63,053,560...63,100,934
Ensembl chr 4:63,076,800...63,089,502

G

aldehyde dehydrogenase 1 family, member A1

increases expression
multiple interactions

clothianidin results in increased expression of ALDH1A1 mRNA
[enilconazole co-treated with clothianidin] results in increased expression of ALDH1A1 mRNA; [thiacloprid co-treated with clothianidin] results in increased expression of ALDH1A1 mRNA

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

archaelysin family metallopeptidase 1

increases expression

clothianidin results in increased expression of AMZ1 mRNA

NCBI chr12:13,886,518...13,924,275
Ensembl chr12:13,891,123...13,909,783

G

ankyrin 3

decreases expression

clothianidin results in decreased expression of ANK3 mRNA

NCBI chr20:18,602,267...19,225,831
Ensembl chr20:18,602,786...19,086,300

G

ankyrin repeat domain 37

decreases expression

clothianidin results in decreased expression of ANKRD37 mRNA

NCBI chr16:46,268,933...46,271,971
Ensembl chr16:46,268,443...46,271,963

G

aprataxin and PNKP like factor

increases expression

clothianidin results in increased expression of APLF mRNA

NCBI chr 4:120,070,471...120,122,656
Ensembl chr 4:120,070,471...120,122,633

G

Rho GTPase activating protein 17

increases expression

clothianidin results in increased expression of ARHGAP17 mRNA

NCBI chr 1:177,807,579...177,897,027
Ensembl chr 1:177,807,583...177,896,854

G

Rho/Rac guanine nucleotide exchange factor 2

increases expression

clothianidin results in increased expression of ARHGEF2 mRNA

NCBI chr 2:174,061,126...174,118,355
Ensembl chr 2:174,062,976...174,118,355

G

ARF like GTPase 11

increases expression

clothianidin results in increased expression of ARL11 mRNA

NCBI chr15:35,483,330...35,485,579
Ensembl chr15:35,480,018...35,496,596

G

ARF like GTPase 14

increases expression

clothianidin results in increased expression of ARL14 mRNA

NCBI chr 2:153,468,863...153,470,102
Ensembl chr 2:153,468,977...153,469,555

G

ARF like GTPase 6

increases expression

clothianidin results in increased expression of ARL6 mRNA

NCBI chr11:40,711,878...40,738,254
Ensembl chr11:40,712,022...40,737,937

G

ankyrin repeat and SOCS box containing 11

increases expression

clothianidin results in increased expression of ASB11 mRNA

NCBI chr X:30,014,485...30,037,808
Ensembl chr X:29,992,416...30,037,807

G

aspartate beta-hydroxylase domain containing 1

decreases expression

clothianidin results in decreased expression of ASPHD1 mRNA

NCBI chr 1:181,552,968...181,556,902
Ensembl chr 1:181,552,884...181,556,090

G

ATPase Na+/K+ transporting subunit alpha 2

decreases expression

clothianidin results in decreased expression of ATP1A2 mRNA

NCBI chr13:84,729,597...84,754,544
Ensembl chr13:84,729,601...84,754,544

G

ATP23 metallopeptidase and ATP synthase assembly factor homolog

increases expression

clothianidin results in increased expression of XRCC6BP1 mRNA

NCBI chr 7:62,714,752...62,729,893
Ensembl chr 7:62,714,785...62,729,862

G

ATPase plasma membrane Ca2+ transporting 3

decreases expression

clothianidin results in decreased expression of ATP2B3 mRNA

NCBI chr X:151,216,483...151,289,069
Ensembl chr X:151,216,507...151,286,775

G

ATPase H+ transporting V0 subunit D2

increases expression

clothianidin results in increased expression of ATP6V0D2 mRNA

NCBI chr 5:33,336,257...33,385,354
Ensembl chr 5:33,336,264...33,385,354

G

acyl-CoA wax alcohol acyltransferase 1

increases expression

clothianidin results in increased expression of AWAT1 mRNA

NCBI chr X:65,668,205...65,674,450
Ensembl chr X:65,668,205...65,674,450

G

axin 1

decreases expression

clothianidin results in decreased expression of AXIN1 mRNA

NCBI chr10:15,163,477...15,215,615
Ensembl chr10:15,163,684...15,215,615

G

antizyme inhibitor 2

decreases expression

clothianidin results in decreased expression of AZIN2 mRNA

NCBI chr 5:141,281,310...141,310,415
Ensembl chr 5:141,281,249...141,310,397

G

BarH-like homeobox 1

increases expression

clothianidin results in increased expression of BARHL1 mRNA

NCBI chr 3:12,241,327...12,248,649
Ensembl chr 3:12,241,327...12,248,649

G

BCR activator of RhoGEF and GTPase

decreases expression

clothianidin results in decreased expression of BCR mRNA

NCBI chr20:13,469,325...13,596,942
Ensembl chr20:13,471,668...13,597,016

G

BICD cargo adaptor 2

decreases expression

clothianidin results in decreased expression of BICD2 mRNA

NCBI chr17:15,259,773...15,304,889
Ensembl chr17:15,259,773...15,304,889

G

BRICHOS domain containing 5

decreases expression

clothianidin results in decreased expression of BRICD5 mRNA

NCBI chr10:13,498,726...13,500,259
Ensembl chr10:13,498,381...13,500,259

G

similar to human chromosome 21 open reading frame 140

increases expression

clothianidin results in increased expression of C21ORF140 mRNA

NCBI chr11:31,549,689...31,552,257
Ensembl chr11:31,544,426...31,552,290

G

chromosome 14 C22orf31 homolog

decreases expression

clothianidin results in decreased expression of C22ORF31 mRNA

G

similar to human chromosome 4 open reading frame 36

decreases expression

clothianidin results in decreased expression of C4ORF36 mRNA

NCBI chr14:6,058,581...6,065,848
Ensembl chr14:6,058,581...6,065,847

G

similar to human chromosome 5 open reading frame 46

increases expression

clothianidin results in increased expression of C5ORF46 mRNA

NCBI chr18:35,948,402...35,969,502
Ensembl chr18:35,948,402...35,969,502

G

similar to human chromosome 16 open reading frame 74

decreases expression

clothianidin results in decreased expression of C16ORF74 mRNA

NCBI chr19:48,660,288...48,686,287
Ensembl chr19:48,660,288...48,686,349

G

similar to human chromosome 21 open reading frame 58

decreases expression

clothianidin results in decreased expression of C21ORF58 mRNA

NCBI chr20:12,167,279...12,188,665
Ensembl chr20:12,175,442...12,187,017

G

C2 calcium-dependent domain containing 4B

increases expression

clothianidin results in increased expression of C2CD4B mRNA

NCBI chr 8:68,372,793...68,396,477
Ensembl chr 8:68,384,847...68,396,328

G

similar to human chromosome 5 open reading frame 34

increases expression

clothianidin results in increased expression of C5ORF34 mRNA

NCBI chr 2:51,553,223...51,577,090
Ensembl chr 2:51,555,432...51,577,085

G

calcium voltage-gated channel auxiliary subunit beta 2

decreases expression

clothianidin results in decreased expression of CACNB2 mRNA

NCBI chr17:77,564,630...77,910,000
Ensembl chr17:77,564,460...77,909,106

G

calcium homeostasis modulator 3

increases expression

clothianidin results in increased expression of CALHM3 mRNA

NCBI chr 1:246,043,258...246,048,259
Ensembl chr 1:246,043,258...246,048,259

G

calpain 5

increases expression

clothianidin results in increased expression of CAPN5 mRNA

NCBI chr 1:152,416,252...152,472,923
Ensembl chr 1:152,416,252...152,472,923

G

calcyphosine

decreases expression

clothianidin results in decreased expression of CAPS mRNA

NCBI chr 9:1,544,597...1,545,631
Ensembl chr 9:1,544,719...1,545,647

G

carbonic anhydrase 3

increases expression

clothianidin results in increased expression of CA3 mRNA

NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280

G

capping protein regulator and myosin 1 linker 1

decreases expression

clothianidin results in decreased expression of CARMIL1 mRNA

NCBI chr17:40,807,921...41,088,326
Ensembl chr17:40,808,389...41,088,326

G

capping protein regulator and myosin 1 linker 3

increases expression

clothianidin results in increased expression of CARMIL3 mRNA

NCBI chr15:28,978,440...28,995,865
Ensembl chr15:28,979,007...28,996,225

G

coiled-coil domain containing 17

decreases expression

clothianidin results in decreased expression of CCDC17 mRNA

NCBI chr 5:130,051,158...130,056,676
Ensembl chr 5:130,045,938...130,056,673

G

coiled-coil domain containing 8

increases expression

clothianidin results in increased expression of CCDC8 mRNA

NCBI chr 1:77,679,521...77,682,849
Ensembl chr 1:77,679,218...77,683,090

G

coiled-coil serine-rich protein 1

decreases expression

clothianidin results in decreased expression of CCSER1 mRNA

NCBI chr 4:90,153,873...91,391,441
Ensembl chr 4:90,292,780...91,388,786

G

CD226 molecule

decreases expression

clothianidin results in decreased expression of CD226 mRNA

NCBI chr18:82,449,924...82,545,107
Ensembl chr18:82,450,568...82,543,051

G

CD34 molecule

increases expression

clothianidin results in increased expression of CD34 mRNA

NCBI chr13:106,480,313...106,500,844
Ensembl chr13:106,480,043...106,499,832

G

CD74 molecule

increases expression

clothianidin results in increased expression of CD74 mRNA

NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003

G

CD8 subunit beta

increases expression

clothianidin results in increased expression of CD8B mRNA

NCBI chr 4:103,312,596...103,328,523
Ensembl chr 4:103,312,578...103,328,553

G

cadherin 8

decreases expression

clothianidin results in decreased expression of CDH8 mRNA

NCBI chr19:5,494,038...5,901,810
Ensembl chr19:5,494,174...5,895,669

G

CMT1A duplicated region transcript 15 like 2

increases expression

clothianidin results in increased expression of CDRT15L2 mRNA

NCBI chr16:11,226,012...11,231,967
Ensembl chr16:11,122,718...11,158,623

G

CEA cell adhesion molecule 6

increases expression

clothianidin results in increased expression of CEACAM6 mRNA

NCBI chr 1:80,416,531...80,434,668
Ensembl chr 1:80,416,531...80,434,668

G

cell migration inducing hyaluronidase 1

increases expression

clothianidin results in increased expression of CEMIP mRNA

NCBI chr 1:137,906,921...138,062,430
Ensembl chr 1:137,908,920...138,062,415

G

carboxylesterase 2H

multiple interactions

[clothianidin co-treated with thiacloprid] results in increased expression of CES2 protein

NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830

G

cilia and flagella associated protein 107

decreases expression

clothianidin results in decreased expression of CFAP107 mRNA

NCBI chr 5:156,212,385...156,231,481
Ensembl chr 5:156,212,385...156,231,481

G

choline O-acetyltransferase

decreases expression

clothianidin results in decreased expression of CHAT mRNA

NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093

G

cholinergic receptor nicotinic alpha 4 subunit

multiple interactions

clothianidin promotes the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]

NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957

G

cholinergic receptor nicotinic alpha 7 subunit

decreases expression

clothianidin results in decreased expression of CHRNA7 mRNA

NCBI chr 1:116,711,559...116,837,269
Ensembl chr 1:116,714,711...116,837,240

G

cholinergic receptor nicotinic beta 2 subunit

multiple interactions

clothianidin results in increased activity of [NACHRA8 protein co-treated with CHRNB2 protein]; clothianidin results in increased activity of [NACHRALPHA1 protein co-treated with CHRNB2 protein]
clothianidin promotes the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]

PMID:16981889 PMID:21538459 PMID:25459289

NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619

G

carbohydrate sulfotransferase 3

increases expression

clothianidin results in increased expression of CHST3 mRNA

NCBI chr20:28,114,386...28,152,046
Ensembl chr20:28,114,404...28,121,807

G

claudin 14

decreases expression

clothianidin results in decreased expression of CLDN14 mRNA

NCBI chr11:33,232,281...33,329,440
Ensembl chr11:33,232,220...33,329,171

G

C-type lectin domain family 3, member B

increases expression

clothianidin results in increased expression of CLEC3B mRNA

NCBI chr 8:122,810,120...122,815,837
Ensembl chr 8:122,810,149...122,815,835

G

CKLF-like MARVEL transmembrane domain containing 5

increases expression

clothianidin results in increased expression of CMTM5 mRNA

NCBI chr15:28,412,624...28,415,304
Ensembl chr15:28,412,624...28,415,287

G

contactin associated protein 1

decreases expression

clothianidin results in decreased expression of CNTNAP1 mRNA

NCBI chr10:86,109,850...86,125,612
Ensembl chr10:86,111,643...86,125,611

G

collagen type XII alpha 1 chain

decreases expression

clothianidin results in decreased expression of COL12A1 mRNA

NCBI chr 8:80,547,592...80,665,665
Ensembl chr 8:80,547,593...80,665,686

G

collagen type I alpha 1 chain

decreases expression

clothianidin results in decreased expression of COL1A1 mRNA

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

collagen type V alpha 2 chain

decreases expression

clothianidin results in decreased expression of COL5A2 mRNA

NCBI chr 9:47,448,741...47,598,134
Ensembl chr 9:47,448,736...47,598,154

G

collagen type VI alpha 2 chain

increases expression

clothianidin results in increased expression of COL6A2 mRNA

NCBI chr20:12,021,676...12,049,425
Ensembl chr20:12,021,767...12,057,564

G

collagen type VII alpha 1 chain

decreases expression

clothianidin results in decreased expression of COL7A1 mRNA

NCBI chr 8:109,604,877...109,637,249
Ensembl chr 8:109,604,861...109,637,252

G

coronin 2B

decreases expression

clothianidin results in decreased expression of CORO2B mRNA

NCBI chr 8:62,906,861...63,017,295
Ensembl chr 8:62,906,867...63,017,302

G

cytoplasmic polyadenylation element binding protein 3

decreases expression

clothianidin results in decreased expression of CPEB3 mRNA

NCBI chr 1:234,749,138...234,931,219
Ensembl chr 1:234,751,733...234,931,560

G

copine 4

increases expression

clothianidin results in increased expression of CPNE4 mRNA

NCBI chr 8:105,177,376...105,653,075
Ensembl chr 8:105,177,376...105,653,068

G

CUB and Sushi multiple domains 1

increases expression

clothianidin results in increased expression of CSMD1 mRNA

NCBI chr16:72,218,189...73,818,380
Ensembl chr16:72,218,503...73,817,614

G

CXADR, Ig-like cell adhesion molecule

increases expression

clothianidin results in increased expression of CXADR mRNA

NCBI chr11:16,982,864...17,030,078
Ensembl chr11:16,982,860...17,030,046

G

cytochrome b-245 alpha chain

decreases expression

clothianidin results in decreased expression of CYBA mRNA

NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721

G

cytochrome P450, family 19, subfamily a, polypeptide 1

affects expression

clothianidin affects the expression of CYP19A1 mRNA

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions
increases expression

[clothianidin co-treated with enilconazole] results in increased expression of CYP1A2 mRNA; [enilconazole co-treated with thiacloprid co-treated with clothianidin] results in increased expression of CYP1A2 mRNA
clothianidin results in increased expression of CYP1A2 mRNA

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

multiple interactions

[clothianidin co-treated with enilconazole] results in increased expression of CYP1B1 protein

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 2, subfamily b, polypeptide 2

increases expression
multiple interactions

clothianidin results in increased expression of CYP2B2 mRNA
[enilconazole co-treated with clothianidin] results in increased expression of CYP2B2 mRNA; [thiacloprid co-treated with clothianidin] results in increased expression of CYP2B2 mRNA

NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566

G

cytochrome P450, family 2, subfamily b, polypeptide 3

multiple interactions

[clothianidin co-treated with thiacloprid] results in increased expression of CYP2B6 protein

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, family 2, subfamily e, polypeptide 1

decreases expression
multiple interactions

clothianidin results in decreased expression of CYP2E1 mRNA
[clothianidin co-treated with enilconazole] results in decreased expression of CYP2E1 mRNA; [clothianidin co-treated with thiacloprid] results in increased expression of CYP2E1 protein; [enilconazole co-treated with thiacloprid co-treated with clothianidin] results in decreased expression of CYP2E1 mRNA; [thiacloprid co-treated with clothianidin] results in decreased expression of CYP2E1 mRNA

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases expression
multiple interactions

clothianidin results in increased expression of CYP3A4 mRNA
[clothianidin co-treated with enilconazole] results in increased expression of CYP3A4 mRNA; [clothianidin co-treated with enilconazole] results in increased expression of CYP3A4 protein; [clothianidin co-treated with thiacloprid] results in increased expression of CYP3A4 protein; [enilconazole co-treated with thiacloprid co-treated with clothianidin] results in increased expression of CYP3A4 mRNA

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1

multiple interactions
increases expression

[enilconazole co-treated with clothianidin] results in increased expression of CYP3A23-3A1 mRNA; [thiacloprid co-treated with clothianidin] results in increased expression of CYP3A23-3A1 mRNA
clothianidin results in increased expression of CYP3A23-3A1 mRNA

NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030

G

cytochrome P450, family 3, subfamily a, polypeptide 9

multiple interactions
increases expression

[clothianidin co-treated with enilconazole] results in increased expression of CYP3A5 protein; [thiacloprid co-treated with clothianidin] results in increased expression of CYP3A5 mRNA
clothianidin results in increased expression of CYP3A5 mRNA

NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422

G

cytochrome P450 family 7 subfamily A member 1

multiple interactions
decreases expression

[enilconazole co-treated with clothianidin] results in decreased expression of CYP7A1 mRNA; [thiacloprid co-treated with clothianidin] results in decreased expression of CYP7A1 mRNA
clothianidin results in decreased expression of CYP7A1 mRNA

NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688

G

cytohesin 4

increases expression

clothianidin results in increased expression of CYTH4 mRNA

NCBI chr 7:110,152,232...110,176,726
Ensembl chr 7:110,152,272...110,176,741

G

dishevelled-binding antagonist of beta-catenin 1

decreases expression

clothianidin results in decreased expression of DACT1 mRNA

NCBI chr 6:89,790,676...89,818,254
Ensembl chr 6:89,790,644...89,817,906

G

defensin alpha 5

decreases expression

clothianidin results in decreased expression of DEFA5 mRNA

NCBI chr16:70,342,530...70,344,854
Ensembl chr16:70,342,530...70,344,836

G

desmin

increases expression

clothianidin results in increased expression of DES mRNA

NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699

G

diacylglycerol kinase, delta

increases expression

clothianidin results in increased expression of DGKD mRNA

NCBI chr 9:88,516,686...88,607,349
Ensembl chr 9:88,516,715...88,607,345

G

iodothyronine deiodinase 3

increases expression

clothianidin results in increased expression of DIO3 mRNA

NCBI chr 6:129,285,747...129,287,608
Ensembl chr 6:129,285,749...129,286,660

G

delta like canonical Notch ligand 3

decreases expression

clothianidin results in decreased expression of DLL3 mRNA

NCBI chr 1:83,562,011...83,570,008
Ensembl chr 1:83,562,014...83,569,750

G

dynein axonemal intermediate chain 7

decreases expression

clothianidin results in decreased expression of DNAI7 mRNA

NCBI chr 4:178,143,499...178,179,871
Ensembl chr 4:178,143,500...178,179,980

G

DnaJ heat shock protein family (Hsp40) member C21

increases expression

clothianidin results in increased expression of DNAJC21 mRNA

NCBI chr 2:59,419,507...59,446,746
Ensembl chr 2:59,419,510...59,446,752

G

DnaJ heat shock protein family (Hsp40) member C28

decreases expression

clothianidin results in decreased expression of DNAJC28 mRNA

NCBI chr11:30,855,566...30,858,386
Ensembl chr11:30,853,526...30,858,441

G

DnaJ heat shock protein family (Hsp40) member C5 gamma

increases expression

clothianidin results in increased expression of DNAJC5G mRNA

NCBI chr 6:25,260,087...25,264,251
Ensembl chr 6:25,260,088...25,264,152

G

deoxyribonuclease 1 like 2

decreases expression

clothianidin results in decreased expression of DNASE1L2 mRNA

NCBI chr10:13,471,850...13,473,447
Ensembl chr10:13,471,479...13,473,763

G

dynein heavy chain domain 1

decreases expression

clothianidin results in decreased expression of DNHD1 mRNA

NCBI chr 1:159,990,785...160,077,990
Ensembl chr 1:159,990,438...160,074,858

G

docking protein 5

decreases expression

clothianidin results in decreased expression of DOK5 mRNA

NCBI chr 3:159,515,886...159,652,811
Ensembl chr 3:159,515,893...159,652,810

G

dihydrouridine synthase 3-like

increases expression

clothianidin results in increased expression of DUS3L mRNA

NCBI chr 9:1,593,491...1,598,663
Ensembl chr 9:1,594,123...1,598,655

G

dual specificity phosphatase 15

increases expression

clothianidin results in increased expression of DUSP15 mRNA

NCBI chr 3:141,408,495...141,419,137
Ensembl chr 3:141,408,498...141,418,999

G

dual specificity phosphatase 16

decreases expression

clothianidin results in decreased expression of DUSP16 mRNA

NCBI chr 4:167,546,780...167,630,173
Ensembl chr 4:167,548,155...167,629,980

G

ELL associated factor 2

decreases expression

clothianidin results in decreased expression of EAF2 mRNA

NCBI chr11:63,960,200...64,004,610
Ensembl chr11:63,960,200...64,004,610

G

endothelin-converting enzyme 2

increases expression

clothianidin results in increased expression of ECE2 mRNA

NCBI chr11:80,259,130...80,278,446
Ensembl chr11:80,263,162...80,278,428

G

EF-hand calcium binding domain 12

decreases expression

clothianidin results in decreased expression of EFCAB12 mRNA

NCBI chr 4:148,869,381...148,892,922
Ensembl chr 4:148,869,387...148,890,560

G

embryonal Fyn-associated substrate

decreases expression

clothianidin results in decreased expression of EFS mRNA

NCBI chr15:28,392,417...28,403,016
Ensembl chr15:28,392,187...28,401,902

G

eukaryotic translation initiation factor 3, subunit F

decreases expression

clothianidin results in decreased expression of EIF3F mRNA

NCBI chr 1:162,934,220...162,943,204
Ensembl chr 1:162,934,212...162,943,204

G

E74 like ETS transcription factor 1

increases expression

clothianidin results in increased expression of ELF1 mRNA

NCBI chr15:54,890,644...54,986,721
Ensembl chr15:54,865,616...54,986,699

G

ELMO domain containing 1

decreases expression

clothianidin results in decreased expression of ELMOD1 mRNA

NCBI chr 8:54,298,363...54,355,348
Ensembl chr 8:54,298,363...54,355,140

G

elastin

multiple interactions
decreases expression

[enilconazole co-treated with clothianidin] results in decreased expression of ELN mRNA; [thiacloprid co-treated with clothianidin] results in decreased expression of ELN mRNA
clothianidin results in decreased expression of ELN mRNA

NCBI chr12:21,968,544...22,011,929
Ensembl chr12:21,968,544...22,011,928

G

ecto-NOX disulfide-thiol exchanger 1

increases expression

clothianidin results in increased expression of ENOX1 mRNA

NCBI chr15:52,517,833...53,079,752
Ensembl chr15:52,515,178...53,079,749

G

ectonucleotide pyrophosphatase/phosphodiesterase 4

increases expression

clothianidin results in increased expression of ENPP4 mRNA

NCBI chr 9:16,888,923...16,898,860
Ensembl chr 9:16,887,739...16,898,860

G

ependymin related 1

increases expression

clothianidin results in increased expression of EPDR1 mRNA

NCBI chr17:45,333,932...45,358,597
Ensembl chr17:45,333,956...45,358,594

G

epsin 3

decreases expression

clothianidin results in decreased expression of EPN3 mRNA

NCBI chr10:79,438,978...79,449,516
Ensembl chr10:79,438,978...79,447,356

G

EGFR pathway substrate 8, signaling adaptor

increases expression

clothianidin results in increased expression of EPS8 mRNA

NCBI chr 4:170,388,378...170,486,873
Ensembl chr 4:170,388,378...170,486,873

G

erb-b2 receptor tyrosine kinase 3

increases expression

clothianidin results in increased expression of ERBB3 mRNA

NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525

G

endoplasmic reticulum-golgi intermediate compartment 1

increases expression

clothianidin results in increased expression of ERGIC1 mRNA

NCBI chr10:16,531,192...16,626,974
Ensembl chr10:16,531,194...16,626,957

G

exocyst complex component 4

decreases expression

clothianidin results in decreased expression of EXOC4 mRNA

NCBI chr 4:61,807,706...62,584,316
Ensembl chr 4:61,807,761...62,585,723

G

enhancer of zeste 2 polycomb repressive complex 2 subunit

decreases expression

clothianidin results in decreased expression of EZH2 mRNA

NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362

G

coagulation factor II, thrombin

decreases expression

clothianidin results in decreased expression of F2 mRNA

NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486

G

family with sequence similarity 110, member C

increases expression

clothianidin results in increased expression of FAM110C mRNA

NCBI chr 6:47,638,466...47,644,723
Ensembl chr 6:47,638,276...47,644,634

G

family with sequence similarity 131, member A

decreases expression

clothianidin results in decreased expression of FAM131A mRNA

NCBI chr11:80,211,577...80,221,527
Ensembl chr11:80,211,745...80,221,511

G

family with sequence similarity 151, member B

decreases expression

clothianidin results in decreased expression of FAM151B mRNA

NCBI chr 2:23,674,317...23,710,420
Ensembl chr 2:23,674,318...23,710,403

G

family with sequence similarity 169, member A

increases expression

clothianidin results in increased expression of FAM169A mRNA

NCBI chr 2:28,384,162...28,441,361
Ensembl chr 2:28,383,784...28,438,910

G

family with sequence similarity 229, member A

decreases expression

clothianidin results in decreased expression of FAM229A mRNA

NCBI chr 5:141,829,716...141,830,705
Ensembl chr 5:141,828,664...141,830,705

G

Fas ligand

increases expression

clothianidin results in increased expression of FASLG mRNA

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

F-box protein 33

decreases expression

clothianidin results in decreased expression of FBXO33 mRNA

NCBI chr 6:76,900,619...76,934,232
Ensembl chr 6:76,900,631...76,932,669

G

fer-1-like family member 4

decreases expression

clothianidin results in decreased expression of FER1L4 mRNA

NCBI chr 3:144,536,099...144,571,634
Ensembl chr 3:144,536,099...144,571,634

G

Fibroblast growth factor receptor 1

increases expression

clothianidin results in increased expression of FGFR1 mRNA

NCBI chr16:66,491,930...66,547,161
Ensembl chr16:66,494,042...66,547,350

G

fragile histidine triad diadenosine triphosphatase

increases expression

clothianidin results in increased expression of FHIT mRNA

NCBI chr15:13,935,029...15,442,620
Ensembl chr15:13,934,995...15,442,340

G

filamin A interacting protein 1

increases expression

clothianidin results in increased expression of FILIP1 mRNA

NCBI chr 8:80,761,283...80,956,556
Ensembl chr 8:80,764,604...80,922,549

G

fat storage-inducing transmembrane protein 1

increases expression

clothianidin results in increased expression of FITM1 mRNA

NCBI chr15:29,064,746...29,066,015
Ensembl chr15:29,064,707...29,066,015

G

folate receptor beta

increases expression

clothianidin results in increased expression of FOLR2 mRNA

NCBI chr 1:156,200,044...156,218,380
Ensembl chr 1:156,200,060...156,205,724

G

FOS like 1, AP-1 transcription factor subunit

increases expression

clothianidin results in increased expression of FOSL1 mRNA

NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930

G

forkhead box O1

increases expression

clothianidin results in increased expression of FOXO1 mRNA

NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790

G

forkhead box O4

decreases expression

clothianidin results in decreased expression of FOXO4 mRNA

NCBI chr X:66,385,241...66,392,115
Ensembl chr X:66,385,558...66,392,115

G

FYN binding protein 1

decreases expression

clothianidin results in decreased expression of FYB1 mRNA

NCBI chr 2:55,621,585...55,781,206
Ensembl chr 2:55,632,698...55,779,629

G

gamma-aminobutyric acid type A receptor subunit gamma 1

increases expression

clothianidin results in increased expression of GABRG1 mRNA

NCBI chr14:37,396,217...37,469,606
Ensembl chr14:37,396,294...37,635,956

G

gamma-aminobutyric acid type A receptor subunit pi

decreases expression

clothianidin results in decreased expression of GABRP mRNA

NCBI chr10:18,143,031...18,169,595
Ensembl chr10:18,143,038...18,169,516

G

golgi associated kinase 1A

increases expression

clothianidin results in increased expression of FAM198A mRNA

NCBI chr 8:121,610,779...121,643,742
Ensembl chr 8:121,610,787...121,642,942

G

growth differentiation factor 15

increases expression

clothianidin results in increased expression of GDF15 mRNA

NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055

G

growth hormone releasing hormone receptor

increases expression

clothianidin results in increased expression of GHRHR mRNA

NCBI chr 4:84,498,159...84,532,851
Ensembl chr 4:84,500,212...84,532,776

G

GLI family zinc finger 1

decreases expression

clothianidin results in decreased expression of GLI1 mRNA

NCBI chr 7:63,156,926...63,169,579
Ensembl chr 7:63,156,926...63,169,251

G

G protein subunit gamma transducin 1

decreases expression

clothianidin results in decreased expression of GNGT1 mRNA

NCBI chr 4:32,006,267...32,009,252
Ensembl chr 4:32,006,267...32,009,252

G

glycine N-methyltransferase

decreases expression

clothianidin results in decreased expression of GNMT mRNA

NCBI chr 9:14,254,675...14,258,028
Ensembl chr 9:14,254,675...14,258,434

G

glypican 6

increases expression

clothianidin results in increased expression of GPC6 mRNA

NCBI chr15:94,030,218...95,027,883
Ensembl chr15:94,029,884...95,024,006

G

glycerophosphocholine phosphodiesterase 1

increases expression

clothianidin results in increased expression of GPCPD1 mRNA

NCBI chr 3:119,787,681...119,832,550
Ensembl chr 3:119,787,682...119,832,517

G

glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1

increases expression

clothianidin results in increased expression of GPIHBP1 mRNA

NCBI chr 7:107,285,584...107,288,702
Ensembl chr 7:107,285,654...107,288,702

G

G protein-coupled receptor 15 ligand

decreases expression

clothianidin results in decreased expression of GPR15LG mRNA

NCBI chr16:12,868,270...12,875,876
Ensembl chr16:12,868,270...12,875,876

G

glutathione peroxidase 4

decreases expression

clothianidin results in decreased expression of GPX4 protein

PMID:25960033 PMID:33563863

NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982

G

GRAM domain containing 1C

decreases expression

clothianidin results in decreased expression of GRAMD1C mRNA

NCBI chr11:56,633,229...56,718,570
Ensembl chr11:56,633,227...56,718,570

G

GRAM domain containing 2A

decreases expression

clothianidin results in decreased expression of GRAMD2A mRNA

NCBI chr 8:60,079,744...60,117,788
Ensembl chr 8:60,080,338...60,115,842

G

GSK3B interacting protein

increases expression

clothianidin results in increased expression of GSKIP mRNA

NCBI chr 6:124,586,087...124,609,106
Ensembl chr 6:124,586,070...124,609,100

G

general transcription factor IIIC subunit 5

increases expression

clothianidin results in increased expression of GTF3C5 mRNA

NCBI chr 3:11,893,867...11,914,187
Ensembl chr 3:11,893,875...11,914,180

G

gametocyte specific factor 1-like

increases expression

clothianidin results in increased expression of GTSF1L mRNA

NCBI chr 3:151,736,020...151,738,715
Ensembl chr 3:151,735,997...151,736,863

G

glycophorin C

increases expression

clothianidin results in increased expression of GYPC mRNA

NCBI chr18:24,160,738...24,193,408
Ensembl chr18:24,160,739...24,193,204

G

H1.7 linker histone

increases expression

clothianidin results in increased expression of H1-7 mRNA

NCBI chr 7:129,408,521...129,409,888
Ensembl chr 7:129,408,359...129,409,930

G

3-hydroxyacyl-CoA dehydratase 2

increases expression

clothianidin results in increased expression of HACD2 mRNA

NCBI chr11:65,667,671...65,762,903
Ensembl chr11:65,670,281...65,762,889

G

HCK proto-oncogene, Src family tyrosine kinase

increases expression

clothianidin results in increased expression of HCK mRNA

NCBI chr 3:141,571,587...141,614,696
Ensembl chr 3:141,571,587...141,614,693

G

HECT domain E3 ubiquitin protein ligase 2

increases expression

clothianidin results in increased expression of HECTD2 mRNA

NCBI chr 1:234,274,967...234,345,598
Ensembl chr 1:234,275,705...234,343,487

G

HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2

decreases expression

clothianidin results in decreased expression of HECW2 mRNA

NCBI chr 9:55,359,462...55,753,106
Ensembl chr 9:55,365,203...55,580,327

G

hepatocyte growth factor

decreases expression

clothianidin results in decreased expression of HGF mRNA

NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409

G

HID1 domain containing

decreases expression

clothianidin results in decreased expression of HID1 mRNA

NCBI chr10:100,589,555...100,610,050
Ensembl chr10:100,589,555...100,610,041

G

hydroxymethylbilane synthase

increases expression

clothianidin results in increased expression of HMBS mRNA

NCBI chr 8:44,673,554...44,680,950
Ensembl chr 8:44,673,554...44,680,957

G

HNF1 homeobox B

increases expression

clothianidin results in increased expression of HNF1B mRNA

NCBI chr10:68,735,894...68,789,888
Ensembl chr10:68,735,894...68,789,888

G

hepatocyte nuclear factor 4, alpha

increases expression

clothianidin results in increased expression of HNF4A mRNA

NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320

G

heterogeneous nuclear ribonucleoprotein K

decreases expression

clothianidin results in decreased expression of HNRNPK mRNA

NCBI chr17:6,262,936...6,275,001
Ensembl chr17:6,262,998...6,274,997

G

intraflagellar transport 70B

decreases expression

clothianidin results in decreased expression of IFT70B mRNA

NCBI chr 3:60,855,809...60,858,380
Ensembl chr 3:60,855,575...60,858,389

G

interleukin 17 receptor E

decreases expression

clothianidin results in decreased expression of IL17RE mRNA

NCBI chr 4:146,604,547...146,618,206
Ensembl chr 4:146,605,526...146,618,206

G

interleukin 18 binding protein

decreases expression

clothianidin results in decreased expression of IL18BP mRNA

NCBI chr 1:156,372,923...156,374,963
Ensembl chr 1:156,372,883...156,374,963

G

interleukin 2 receptor subunit gamma

increases expression

clothianidin results in increased expression of IL2RG mRNA

NCBI chr X:66,395,330...66,399,026
Ensembl chr X:66,392,542...66,399,823

G

inner mitochondrial membrane peptidase subunit 1

increases expression

clothianidin results in increased expression of IMMP1L mRNA

NCBI chr 3:92,385,329...92,449,559
Ensembl chr 3:92,385,379...92,452,313

G

inhibin subunit beta A

increases expression

clothianidin results in increased expression of INHBA mRNA

NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982

G

inhibitory synaptic factor family member 2B

decreases expression

clothianidin results in decreased expression of INSYN2B mRNA

NCBI chr10:18,916,721...19,023,859
Ensembl chr10:19,003,131...19,022,139

G

iroquois homeobox 5

decreases expression

clothianidin results in decreased expression of IRX5 mRNA

NCBI chr19:14,639,052...14,643,911
Ensembl chr19:14,624,225...14,642,318

G

intersectin 1

decreases expression

clothianidin results in decreased expression of ITSN1 mRNA

NCBI chr11:30,978,590...31,160,645
Ensembl chr11:30,978,590...31,160,645

G

Janus kinase 2

decreases expression

clothianidin results in decreased expression of JAK2 mRNA

NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189

G

lysine acetyltransferase 6B

decreases expression

clothianidin results in decreased expression of KAT6B mRNA

NCBI chr15:2,638,885...2,811,977
Ensembl chr15:2,639,200...2,812,316

G

potassium voltage-gated channel subfamily C member 4

increases expression

clothianidin results in increased expression of KCNC4 mRNA

NCBI chr 2:195,063,967...195,100,244
Ensembl chr 2:195,071,769...195,099,233

G

potassium voltage-gated channel subfamily D member 3

decreases expression

clothianidin results in decreased expression of KCND3 mRNA

NCBI chr 2:192,937,950...193,155,345
Ensembl chr 2:192,937,950...193,155,345

G

potassium two pore domain channel subfamily K member 1

decreases expression

clothianidin results in decreased expression of KCNK1 mRNA

NCBI chr19:53,959,411...53,997,726
Ensembl chr19:53,959,657...53,997,724

G

potassium calcium-activated channel subfamily M alpha 1

decreases expression

clothianidin results in decreased expression of KCNMA1 mRNA

PMID:31626844 PMID:35690182

NCBI chr15:302,480...1,007,675
Ensembl chr15:302,214...1,001,198

G

kinesin family member 7

increases expression

clothianidin results in increased expression of KIF7 mRNA

NCBI chr 1:133,639,487...133,658,539
Ensembl chr 1:133,640,065...133,658,576

G

kinesin family member C3

increases expression

clothianidin results in increased expression of KIFC3 mRNA

NCBI chr19:9,825,114...9,920,371
Ensembl chr19:9,886,693...9,920,451

G

KIT proto-oncogene receptor tyrosine kinase

increases expression

clothianidin results in increased expression of KIT mRNA

NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652

G

kelch domain containing 9

decreases expression

clothianidin results in decreased expression of KLHDC9 mRNA

NCBI chr13:83,790,390...83,794,080
Ensembl chr13:83,790,269...83,793,354

G

karyopherin subunit alpha 6

increases expression

clothianidin results in increased expression of KPNA6 mRNA

NCBI chr 5:141,988,111...142,021,483
Ensembl chr 5:141,991,568...142,021,120

G

keratin 28

increases expression

clothianidin results in increased expression of KRT28 mRNA

NCBI chr10:84,318,352...84,328,693
Ensembl chr10:84,318,543...84,328,643

G

kinase suppressor of ras 1

decreases expression

clothianidin results in decreased expression of KSR1 mRNA

NCBI chr10:63,961,771...64,098,076
Ensembl chr10:63,961,759...64,098,076

G

kyphoscoliosis peptidase

multiple interactions
decreases expression

[enilconazole co-treated with clothianidin] results in decreased expression of KY mRNA; [thiacloprid co-treated with clothianidin] results in decreased expression of KY mRNA
clothianidin results in decreased expression of KY mRNA

NCBI chr 8:103,086,959...103,126,305
Ensembl chr 8:103,086,630...103,126,024

G

L3MBTL histone methyl-lysine binding protein 1

decreases expression

clothianidin results in decreased expression of L3MBTL1 mRNA

NCBI chr 3:151,597,903...151,633,657
Ensembl chr 3:151,602,980...151,631,233

G

galectin 12

increases expression

clothianidin results in increased expression of LGALS12 mRNA

NCBI chr 1:204,832,065...204,842,759
Ensembl chr 1:204,832,065...204,842,759

G

leucine-rich repeat LGI family, member 4

increases expression

clothianidin results in increased expression of LGI4 mRNA

NCBI chr 1:86,294,539...86,305,909
Ensembl chr 1:86,295,074...86,304,874

G

LIF, interleukin 6 family cytokine

decreases expression

clothianidin results in decreased expression of LIF mRNA

NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482

G

lens intrinsic membrane protein 2

increases expression

clothianidin results in increased expression of LIM2 mRNA

NCBI chr 1:93,837,597...93,843,769
Ensembl chr 1:93,837,597...93,843,769

G

LON peptidase N-terminal domain and ring finger 1

increases expression

clothianidin results in increased expression of LONRF1 mRNA

NCBI chr16:55,984,572...56,015,156
Ensembl chr16:55,984,463...56,015,156

G

lysyl oxidase

increases expression

clothianidin results in increased expression of LOX mRNA

NCBI chr18:45,964,544...45,977,431
Ensembl chr18:45,967,343...46,041,477

G

lysophosphatidic acid receptor 1

decreases expression

clothianidin results in decreased expression of LPAR1 mRNA

NCBI chr 5:73,229,047...73,347,874
Ensembl chr 5:73,229,625...73,369,895

G

leucine-rich repeats and immunoglobulin-like domains 1

increases expression

clothianidin results in increased expression of LRIG1 mRNA

NCBI chr 4:127,130,899...127,230,956
Ensembl chr 4:127,130,898...127,231,513

G

leucine rich melanocyte differentiation associated

decreases expression

clothianidin results in decreased expression of LRMDA mRNA

NCBI chr15:1,223,098...2,284,764
Ensembl chr15:1,225,710...2,284,749

G

leucine rich repeat containing 74B

decreases expression

clothianidin results in decreased expression of LRRC74B mRNA

NCBI chr11:83,450,588...83,468,906
Ensembl chr11:83,450,624...83,468,922

G

leucine zipper protein 2

increases expression

clothianidin results in increased expression of LUZP2 mRNA

NCBI chr 1:105,597,291...105,983,605
Ensembl chr 1:105,597,307...105,981,183

G

LysM domain containing 2

decreases expression

clothianidin results in decreased expression of LYSMD2 mRNA

NCBI chr 8:76,378,984...76,394,396
Ensembl chr 8:76,379,219...76,394,654

G

mitogen activated protein kinase 1

increases phosphorylation

clothianidin results in increased phosphorylation of MAPK1 protein

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

increases phosphorylation

clothianidin results in increased phosphorylation of MAPK3 protein

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

melanin-concentrating hormone receptor 1

increases expression

clothianidin results in increased expression of MCHR1 mRNA

NCBI chr 7:112,761,554...112,764,746
Ensembl chr 7:112,761,554...112,764,032

G

multiple EGF-like-domains 11

multiple interactions
decreases expression

[enilconazole co-treated with clothianidin] results in decreased expression of MEGF11 mRNA; [thiacloprid co-treated with clothianidin] results in decreased expression of MEGF11 mRNA
clothianidin results in decreased expression of MEGF11 mRNA

NCBI chr 8:64,892,312...65,218,984
Ensembl chr 8:64,892,387...65,216,061

G

meiosis specific with coiled-coil domain

increases expression

clothianidin results in increased expression of MEIOC mRNA

NCBI chr10:87,628,807...87,646,485
Ensembl chr10:87,628,875...87,646,752

G

methyltransferase 16, RNA N6-adenosine

increases expression

clothianidin results in increased expression of METTL16 mRNA

NCBI chr10:59,640,915...59,697,291
Ensembl chr10:59,640,972...59,687,061

G

microtubule associated monooxygenase, calponin and LIM domain containing 1

increases expression

clothianidin results in increased expression of MICAL1 mRNA

NCBI chr20:44,974,137...44,986,089
Ensembl chr20:44,974,138...44,986,089

G

MICAL-like 2

decreases expression

clothianidin results in decreased expression of MICALL2 mRNA

NCBI chr12:14,899,188...14,927,949
Ensembl chr12:14,899,157...14,927,946

G

melan-A

increases expression

clothianidin results in increased expression of MLANA mRNA

NCBI chr 1:227,469,537...227,483,343
Ensembl chr 1:227,469,537...227,483,343

G

membrane metallo-endopeptidase

multiple interactions
increases expression

[enilconazole co-treated with clothianidin] results in increased expression of MME mRNA; [thiacloprid co-treated with clothianidin] results in increased expression of MME mRNA
clothianidin results in increased expression of MME mRNA

NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792

G

matrix metallopeptidase 10

increases expression

clothianidin results in increased expression of MMP10 mRNA

NCBI chr 8:4,689,840...4,697,748
Ensembl chr 8:4,689,840...4,697,748

G

membrane spanning 4-domains A2

decreases expression

clothianidin results in decreased expression of MS4A2 mRNA

NCBI chr 1:208,440,179...208,448,716
Ensembl chr 1:208,440,361...208,448,310

G

MSS51 mitochondrial translational activator

decreases expression

clothianidin results in decreased expression of MSS51 mRNA

NCBI chr15:3,805,240...3,819,385
Ensembl chr15:3,807,516...3,819,385

G

mitochondrial ribosome-associated GTPase 1

decreases expression

clothianidin results in decreased expression of MTG1 mRNA

NCBI chr 1:194,931,543...194,944,278
Ensembl chr 1:194,931,531...194,944,277

G

myosin light chain 11

decreases expression

clothianidin results in decreased expression of MYL11 mRNA

NCBI chr 1:181,829,703...181,832,546
Ensembl chr 1:181,829,743...181,832,545

G

myosin, light chain 4

decreases expression

clothianidin results in decreased expression of MYL4 mRNA

NCBI chr10:89,449,456...89,485,365
Ensembl chr10:89,449,443...89,485,363

G

myosin light chain 6

decreases expression

clothianidin results in decreased expression of MYL6 mRNA

NCBI chr 7:910,764...914,062
Ensembl chr 7:910,774...933,791

G

myosin IIIB

increases expression

clothianidin results in increased expression of MYO3B mRNA

NCBI chr 3:54,820,225...55,228,518
Ensembl chr 3:54,820,251...55,227,373

G

myogenesis regulating glycosidase

increases expression

clothianidin results in increased expression of MYORG mRNA

NCBI chr 5:56,654,257...56,664,467
Ensembl chr 5:56,648,643...56,664,440

G

myelin transcription factor 1-like

increases expression

clothianidin results in increased expression of MYT1L mRNA

NCBI chr 6:46,164,742...46,564,234
Ensembl chr 6:46,428,150...46,561,671

G

NEDD4 binding protein 2-like 1

increases expression

clothianidin results in increased expression of N4BP2L1 mRNA

NCBI chr12:102,572...128,352
Ensembl chr12:102,573...127,257

G

NAD synthetase 1

decreases expression

clothianidin results in decreased expression of NADSYN1 mRNA

NCBI chr 1:198,981,559...199,009,853
Ensembl chr 1:198,981,604...199,009,869

G

nuclear autoantigenic sperm protein

decreases expression

clothianidin results in decreased expression of NASP mRNA

NCBI chr 5:130,057,363...130,083,003
Ensembl chr 5:130,057,363...130,082,928

G

neutrophil cytosolic factor 2

increases expression

clothianidin results in increased expression of NCF2 mRNA

NCBI chr13:64,955,622...64,986,144
Ensembl chr13:64,955,503...64,986,277

G

NADH:ubiquinone oxidoreductase subunit A10

increases expression

clothianidin results in increased expression of NDUFA10 mRNA

NCBI chr 9:93,007,034...93,041,825
Ensembl chr 9:93,007,042...93,042,560

G

nectin cell adhesion molecule 4

decreases expression

clothianidin results in decreased expression of NECTIN4 mRNA

NCBI chr13:83,802,589...83,821,711
Ensembl chr13:83,803,184...83,821,709

G

neuronal differentiation 4

decreases expression

clothianidin results in decreased expression of NEUROD4 mRNA

NCBI chr 7:7,090,048...7,102,018
Ensembl chr 7:7,090,045...7,102,030

G

neuronal guanine nucleotide exchange factor

increases expression

clothianidin results in increased expression of NGEF mRNA

NCBI chr 9:88,146,956...88,244,454
Ensembl chr 9:88,146,956...88,244,914

G

nerve growth factor receptor

increases expression

clothianidin results in increased expression of NGFR mRNA

NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518

G

ninein-like

decreases expression

clothianidin results in decreased expression of NINL mRNA

NCBI chr 3:139,748,353...139,814,683
Ensembl chr 3:139,748,355...139,814,622

G

nitric oxide synthase 2

increases expression

clothianidin results in increased expression of NOS2 mRNA

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

nuclear receptor subfamily 0, group B, member 2

decreases expression
multiple interactions

clothianidin results in decreased expression of NR0B2 mRNA
[clothianidin co-treated with enilconazole] results in decreased expression of NR0B2 mRNA

NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609

G

netrin 4

decreases expression

clothianidin results in decreased expression of NTN4 mRNA

NCBI chr 7:28,186,611...28,300,390
Ensembl chr 7:28,186,611...28,300,390

G

neurotensin

decreases expression

clothianidin results in decreased expression of NTS mRNA

NCBI chr 7:37,564,944...37,574,350
Ensembl chr 7:37,564,533...37,574,423

G

nucleoredoxin-like 2

increases expression

clothianidin results in increased expression of NXNL2 mRNA

NCBI chr17:14,031,151...14,035,897
Ensembl chr17:14,031,153...14,036,189

G

neurexophilin 2

increases expression

clothianidin results in increased expression of NXPH2 mRNA

NCBI chr 3:5,986,175...5,988,525
Ensembl chr 3:5,756,621...5,987,008

G

OCRL, inositol polyphosphate-5-phosphatase

decreases expression

clothianidin results in decreased expression of OCRL mRNA

NCBI chr X:127,089,508...127,140,362
Ensembl chr X:127,089,590...127,140,362

G

olfactory receptor 59

increases expression

clothianidin results in increased expression of OR51E2 mRNA

NCBI chr 1:157,193,051...157,227,707
Ensembl chr 1:157,193,080...157,211,179

G

OTU deubiquitinase 6B

increases expression

clothianidin results in increased expression of OTUD6B mRNA

NCBI chr 5:28,181,992...28,214,486
Ensembl chr 5:28,023,594...28,214,334

G

peptidyl arginine deiminase 4

increases expression

clothianidin results in increased expression of PADI4 mRNA

NCBI chr 5:153,041,351...153,074,412
Ensembl chr 5:153,041,352...153,074,362

G

p21 (RAC1) activated kinase 5

decreases expression

clothianidin results in decreased expression of PAK5 mRNA

PMID:31626844 PMID:35690182

NCBI chr 3:123,395,678...123,703,967
Ensembl chr 3:123,396,497...123,703,930

G

progestin and adipoQ receptor family member 8

decreases expression

clothianidin results in decreased expression of PAQR8 mRNA

NCBI chr 9:23,312,521...23,362,175
Ensembl chr 9:23,312,585...23,362,340

G

phenazine biosynthesis-like protein domain containing 1

decreases expression

clothianidin results in decreased expression of PBLD mRNA

NCBI chr20:25,551,274...25,566,543
Ensembl chr20:25,551,275...25,565,614

G

propionyl-CoA carboxylase subunit alpha

decreases expression

clothianidin results in decreased expression of PCCA mRNA

NCBI chr15:99,627,955...99,969,555
Ensembl chr15:99,627,982...99,968,266

G

proprotein convertase subtilisin/kexin type 1

decreases expression

clothianidin results in decreased expression of PCSK1 mRNA

NCBI chr 2:4,395,543...4,442,434
Ensembl chr 2:4,395,543...4,442,434

G

phosphodiesterase 10A

decreases expression

clothianidin results in decreased expression of PDE10A mRNA

NCBI chr 1:51,765,743...52,218,086
Ensembl chr 1:51,770,132...52,216,563

G

phosphodiesterase 1C

increases expression

clothianidin results in increased expression of PDE1C mRNA

NCBI chr 4:85,300,858...85,777,948
Ensembl chr 4:85,300,858...85,863,219

G

phosphodiesterase 4D interacting protein

increases expression

clothianidin results in increased expression of PDE4DIP mRNA

NCBI chr 2:185,293,236...185,490,100
Ensembl chr 2:185,293,214...185,468,379

G

PDZ domain containing 7

decreases expression

clothianidin results in decreased expression of PDZD7 mRNA

NCBI chr 1:243,888,295...243,907,778
Ensembl chr 1:243,888,281...243,906,839

G

pellino E3 ubiquitin protein ligase family member 2

decreases expression

clothianidin results in decreased expression of PELI2 mRNA

NCBI chr15:21,393,262...21,537,737
Ensembl chr15:21,393,262...21,535,106

G

post-GPI attachment to proteins 6

decreases expression

clothianidin results in decreased expression of PGAP6 mRNA

NCBI chr10:15,138,918...15,148,431
Ensembl chr10:15,138,959...15,148,431

G

progesterone receptor

increases expression

clothianidin results in increased expression of PGR mRNA

NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344

G

PH domain containing endocytic trafficking adaptor 2

increases expression

clothianidin results in increased expression of FAM109B mRNA

NCBI chr 7:113,855,437...113,861,910
Ensembl chr 7:113,857,249...113,861,871

G

phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta

decreases expression

clothianidin results in decreased expression of PIK3C2B mRNA

NCBI chr13:44,494,673...44,555,663
Ensembl chr13:44,495,050...44,555,612

G

phosphatidylinositol-4-phosphate 5-kinase type 1 gamma

decreases expression

clothianidin results in decreased expression of PIP5K1C mRNA

NCBI chr 7:8,397,406...8,426,030
Ensembl chr 7:8,397,406...8,425,988

G

phosphatidylinositol-4-phosphate 5-kinase-like 1

decreases expression

clothianidin results in decreased expression of PIP5KL1 mRNA

NCBI chr 3:15,860,493...15,869,264
Ensembl chr 3:15,855,946...15,869,165

G

phospholipase A2 group IIA

increases expression

clothianidin results in increased expression of PLA2G2A mRNA

NCBI chr 5:151,076,442...151,079,019
Ensembl chr 5:151,076,442...151,079,014

G

phospholipase B domain containing 1

decreases expression

clothianidin results in decreased expression of PLBD1 mRNA

NCBI chr 4:169,472,983...169,529,277
Ensembl chr 4:169,472,983...169,529,277

G

phospholipase C, delta 1

increases expression

clothianidin results in increased expression of PLCD1 mRNA

NCBI chr 8:118,795,196...118,818,186
Ensembl chr 8:118,795,201...118,818,186

G

phospholipase C, delta 3

decreases expression

clothianidin results in decreased expression of PLCD3 mRNA

NCBI chr10:88,026,707...88,048,080
Ensembl chr10:88,026,740...88,048,296

G

phospholipase C-like 1

decreases expression

clothianidin results in decreased expression of PLCL1 mRNA

NCBI chr 9:56,901,573...57,238,782
Ensembl chr 9:56,901,534...57,238,782

G

plasmolipin

increases expression

clothianidin results in increased expression of PLLP mRNA

NCBI chr19:10,315,104...10,335,892
Ensembl chr19:10,315,104...10,335,892

G

patatin-like phospholipase domain containing 1

increases expression

clothianidin results in increased expression of PNPLA1 mRNA

NCBI chr20:6,917,993...6,952,157
Ensembl chr20:6,917,931...6,952,375

G

RNA polymerase II subunit M

decreases expression

clothianidin results in decreased expression of POLR2M mRNA

NCBI chr 8:72,131,992...72,139,423
Ensembl chr 8:72,131,530...72,243,036

G

protein phosphatase 1, regulatory subunit 3C

increases expression

clothianidin results in increased expression of PPP1R3C mRNA

NCBI chr 1:234,460,958...234,465,961
Ensembl chr 1:234,460,652...234,465,961

G

protein phosphatase 3 catalytic subunit gamma

increases expression

clothianidin results in increased expression of PPP3CC mRNA

NCBI chr15:45,289,917...45,362,012
Ensembl chr15:45,290,373...45,361,832

G

proteoglycan 3, pro eosinophil major basic protein 2

increases expression

clothianidin results in increased expression of PRG3 mRNA

NCBI chr 3:70,071,970...70,078,103
Ensembl chr 3:70,072,497...70,078,102

G

parkin RBR E3 ubiquitin protein ligase

decreases expression

clothianidin results in decreased expression of PARK2 mRNA

NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555

G

prolactin receptor

decreases expression

clothianidin results in decreased expression of PRLR mRNA

NCBI chr 2:59,134,147...59,324,719
Ensembl chr 2:59,134,588...59,324,718

G

prion like protein doppel

increases expression

clothianidin results in increased expression of PRND mRNA

NCBI chr 3:119,213,462...119,218,742
Ensembl chr 3:119,213,429...119,218,745

G

proline dehydrogenase 2

increases expression

clothianidin results in increased expression of PRODH2 mRNA

NCBI chr 1:85,753,558...85,767,165
Ensembl chr 1:85,753,644...85,767,162

G

proline rich 5 like

increases expression

clothianidin results in increased expression of PRR5L mRNA

NCBI chr 3:88,001,951...88,173,532
Ensembl chr 3:88,003,617...88,082,763

G

peroxiredoxin like 2B

decreases expression

clothianidin results in decreased expression of PRXL2B mRNA

NCBI chr 5:165,462,610...165,465,213

G

presenilin 1

decreases expression

clothianidin results in decreased expression of PSEN1 mRNA

NCBI chr 6:103,323,052...103,375,088
Ensembl chr 6:103,323,120...103,371,650

G

proteasome 26S subunit, ATPase 6

decreases expression

clothianidin results in decreased expression of PSMC6 mRNA

NCBI chr15:18,542,585...18,564,057
Ensembl chr15:18,542,563...18,564,055

G

prostaglandin F receptor

decreases expression

clothianidin results in decreased expression of PTGFR mRNA

NCBI chr 2:240,731,185...240,766,674
Ensembl chr 2:240,733,375...240,765,650

G

protein tyrosine phosphatase, non-receptor type 3

increases expression

clothianidin results in increased expression of PTPN3 mRNA

NCBI chr 5:71,908,520...72,027,323
Ensembl chr 5:71,911,135...72,065,443

G

protein tyrosine phosphatase, receptor type, B

decreases expression

clothianidin results in decreased expression of PTPRB mRNA

NCBI chr 7:51,953,375...52,034,751
Ensembl chr 7:51,930,015...52,034,748

G

protein tyrosine phosphatase, receptor type, O

decreases expression

clothianidin results in decreased expression of PTPRO mRNA

NCBI chr 4:170,164,071...170,374,790
Ensembl chr 4:170,164,431...170,374,771

G

glutaminyl-peptide cyclotransferase

increases expression

clothianidin results in increased expression of QPCT mRNA

NCBI chr 6:15,964,656...15,996,730
Ensembl chr 6:15,964,657...15,996,711

G

recombination activating 1

decreases expression

clothianidin results in decreased expression of RAG1 mRNA

NCBI chr 3:87,917,061...87,928,158
Ensembl chr 3:87,917,004...87,928,291

G

Rap guanine nucleotide exchange factor like 1

decreases expression

clothianidin results in decreased expression of RAPGEFL1 mRNA

NCBI chr10:83,793,711...83,810,373
Ensembl chr10:83,793,694...83,810,371

G

RNA binding motif protein 26

decreases expression

clothianidin results in decreased expression of RBM26 mRNA

NCBI chr15:81,884,783...81,964,245
Ensembl chr15:81,887,219...81,964,118

G

RNA binding motif, single stranded interacting protein 1

decreases expression

clothianidin results in decreased expression of RBMS1 mRNA

NCBI chr 3:45,195,828...45,420,406
Ensembl chr 3:45,197,972...45,420,376

G

regenerating family member 3 gamma

increases expression

clothianidin results in increased expression of REG3G mRNA

NCBI chr 4:110,922,805...110,927,803
Ensembl chr 4:110,924,168...110,926,723

G

Rieske (Fe-S) domain containing

decreases expression

clothianidin results in decreased expression of RFESD mRNA

NCBI chr 2:5,495,067...5,521,095
Ensembl chr 2:5,505,756...5,522,449

G

regulatory subunit of type II PKA R-subunit domain containing 1

decreases expression

clothianidin results in decreased expression of RIIAD1 mRNA

NCBI chr 2:182,099,924...182,110,544
Ensembl chr 2:182,101,795...182,110,319

G

Rho family GTPase 1

increases expression

clothianidin results in increased expression of RND1 mRNA

NCBI chr 7:129,821,311...129,828,385
Ensembl chr 7:129,821,311...129,828,399

G

RP1 like 1

increases expression

clothianidin results in increased expression of RP1L1 mRNA

NCBI chr15:38,259,907...38,271,269
Ensembl chr15:38,259,928...38,270,316

G

ribosomal protein S29

increases expression

clothianidin results in increased expression of RPS29 mRNA

NCBI chr 6:87,635,229...87,636,627
Ensembl chr 6:87,635,230...87,636,636
Ensembl chr13:87,635,230...87,636,636

G

RRAD, Ras related glycolysis inhibitor and calcium channel regulator

increases expression

clothianidin results in increased expression of RRAD mRNA

NCBI chr19:354,184...357,424
Ensembl chr19:354,198...357,417

G

RT1 class II, locus Bb

increases expression

clothianidin results in increased expression of HLA-DQB1 mRNA

NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597

G

S100 calcium binding protein A5

decreases expression

clothianidin results in decreased expression of S100A5 mRNA

NCBI chr 2:176,095,332...176,099,546
Ensembl chr 2:176,097,539...176,099,546

G

SAM and SH3 domain containing 3

increases expression

clothianidin results in increased expression of SASH3 mRNA

NCBI chr X:127,326,815...127,341,521
Ensembl chr X:127,326,859...127,341,519

G

sodium voltage-gated channel alpha subunit 7

decreases expression

clothianidin results in decreased expression of SCN7A mRNA

NCBI chr 3:51,335,841...51,438,308
Ensembl chr 3:51,335,841...51,438,256

G

sodium channel epithelial 1 subunit beta

increases expression

clothianidin results in increased expression of SCNN1B mRNA

NCBI chr 1:176,430,063...176,484,451
Ensembl chr 1:176,430,103...176,484,451

G

semaphorin 3F

decreases expression

clothianidin results in decreased expression of SEMA3F mRNA

NCBI chr 8:108,357,629...108,386,569
Ensembl chr 8:108,357,629...108,387,083

G

stress-associated endoplasmic reticulum protein 1

decreases expression

clothianidin results in decreased expression of SERP1 mRNA

NCBI chr 2:142,757,254...142,761,243
Ensembl chr 2:142,757,270...142,761,116

G

serpin family A member 3N

decreases expression

clothianidin results in decreased expression of SERPINA3N mRNA

NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433

G

serpin family C member 1

decreases expression

clothianidin results in decreased expression of SERPINC1 mRNA

NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293

G

serpin family E member 1

decreases expression

clothianidin results in decreased expression of SERPINE1 mRNA

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

sarcoglycan, delta

increases expression

clothianidin results in increased expression of SGCD mRNA

NCBI chr10:31,346,480...32,328,364
Ensembl chr10:31,280,511...31,724,840

G

serum/glucocorticoid regulated kinase 2

decreases expression

clothianidin results in decreased expression of SGK2 mRNA

NCBI chr 3:151,644,102...151,669,480
Ensembl chr 3:151,644,102...151,669,480

G

SH3 domain and tetratricopeptide repeats 1

increases expression

clothianidin results in increased expression of SH3TC1 mRNA

NCBI chr14:75,005,691...75,050,001
Ensembl chr14:75,016,875...75,049,995

G

signal-induced proliferation-associated 1 like 2

increases expression

clothianidin results in increased expression of SIPA1L2 mRNA

NCBI chr19:53,389,792...53,540,466
Ensembl chr19:53,389,805...53,540,428

G

solute carrier family 14 member 1 (Kidd blood group)

decreases expression

clothianidin results in decreased expression of SLC14A1 mRNA

NCBI chr18:71,565,453...71,608,807
Ensembl chr18:71,565,454...71,595,146

G

solute carrier family 17 member 7

decreases expression

clothianidin results in decreased expression of SLC17A7 mRNA

NCBI chr 1:95,649,709...95,661,591
Ensembl chr 1:95,649,745...95,661,588

G

solute carrier family 22 member 2

decreases activity

clothianidin results in decreased activity of SLC22A2 protein

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

solute carrier family 22 member 6

decreases activity

clothianidin results in decreased activity of SLC22A6 protein

NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173

G

solute carrier family 22 member 8

decreases activity

clothianidin results in decreased activity of SLC22A8 protein

NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450

G

solute carrier family 28 member 1

increases expression

clothianidin results in increased expression of SLC28A1 mRNA

NCBI chr 1:135,079,375...135,122,791
Ensembl chr 1:135,081,385...135,122,464

G

solute carrier family 38, member 9

decreases expression

clothianidin results in decreased expression of SLC38A9 mRNA

NCBI chr 2:44,291,637...44,374,897
Ensembl chr 2:44,291,989...44,368,955

G

solute carrier family 45, member 2

decreases expression

clothianidin results in decreased expression of SLC45A2 mRNA

NCBI chr 2:59,963,599...59,996,408
Ensembl chr 2:59,963,706...59,996,317

G

solute carrier family 47 member 2

decreases activity

clothianidin results in decreased activity of SLC47A2 protein

NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904

G

solute carrier family 48 member 1

increases expression

clothianidin results in increased expression of SLC48A1 mRNA

NCBI chr 7:128,915,136...128,923,929
Ensembl chr 7:128,915,195...128,923,024

G

solute carrier family 6 member 1

decreases expression
multiple interactions

clothianidin results in decreased expression of SLC6A1 mRNA
[enilconazole co-treated with clothianidin] results in decreased expression of SLC6A1 mRNA; [thiacloprid co-treated with clothianidin] results in decreased expression of SLC6A1 mRNA

NCBI chr 4:147,448,961...147,482,295
Ensembl chr 4:147,466,965...147,482,293

G

solute carrier organic anion transporter family, member 1c1

increases expression

clothianidin results in increased expression of SLCO1C1 mRNA

NCBI chr 4:174,466,621...174,513,290
Ensembl chr 4:174,466,631...174,513,289

G

sphingomyelin phosphodiesterase 3

decreases expression

clothianidin results in decreased expression of SMPD3 mRNA

NCBI chr19:34,162,337...34,245,786
Ensembl chr19:34,162,341...34,245,749

G

sorbin and SH3 domain containing 1

increases expression

clothianidin results in increased expression of SORBS1 mRNA

NCBI chr 1:239,107,882...239,330,276
Ensembl chr 1:239,108,777...239,330,169

G

spermatogenesis associated 3

increases expression

clothianidin results in increased expression of SPATA3 mRNA

NCBI chr 9:86,660,352...86,672,272
Ensembl chr 9:86,659,784...86,672,272

G

spire-type actin nucleation factor 2

decreases expression

clothianidin results in decreased expression of SPIRE2 mRNA

NCBI chr19:51,373,368...51,411,920
Ensembl chr19:51,373,228...51,411,920

G

steroid 5 alpha-reductase 2

increases expression

clothianidin results in increased expression of SRD5A2 mRNA

NCBI chr 6:21,426,225...21,465,727
Ensembl chr 6:21,426,215...21,462,112

G

SCO-spondin

decreases expression

clothianidin results in decreased expression of SSPOP mRNA

NCBI chr 4:77,394,915...77,450,526
Ensembl chr 4:77,397,059...77,450,412

G

SH3 and cysteine rich domain 2

increases expression

clothianidin results in increased expression of STAC2 mRNA

NCBI chr10:83,032,418...83,048,260
Ensembl chr10:83,032,417...83,048,260

G

STEAP2 metalloreductase

increases expression

clothianidin results in increased expression of STEAP2 mRNA

NCBI chr 4:28,347,769...28,368,177
Ensembl chr 4:28,348,362...28,375,791

G

sushi domain containing 4

increases expression

clothianidin results in increased expression of SUSD4 mRNA

NCBI chr13:94,455,180...94,577,773
Ensembl chr13:94,455,165...94,577,750

G

synaptonemal complex protein 2

decreases expression

clothianidin results in decreased expression of SYCP2 mRNA

NCBI chr 3:165,431,715...165,502,134
Ensembl chr 3:165,436,331...165,498,789

G

synaptopodin

decreases expression

clothianidin results in decreased expression of SYNPO mRNA

NCBI chr18:54,048,299...54,106,388
Ensembl chr18:54,026,152...54,102,126

G

tachykinin receptor 1

increases expression

clothianidin results in increased expression of TACR1 mRNA

NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:114,920,844...115,089,733

G

TAFA chemokine like family member 2

decreases expression

clothianidin results in decreased expression of FAM19A2 mRNA

NCBI chr 7:58,942,598...59,418,640
Ensembl chr 7:58,942,610...59,417,299

G

TAFA chemokine like family member 5

increases expression

clothianidin results in increased expression of FAM19A5 mRNA

NCBI chr 7:118,613,731...118,835,016
Ensembl chr 7:118,613,889...118,834,353

G

T-box transcription factor 2

increases expression

clothianidin results in increased expression of TBX2 mRNA

NCBI chr10:70,679,670...70,688,868
Ensembl chr10:70,679,518...70,688,529

G

t-complex protein 10b

increases expression

clothianidin results in increased expression of TCP10L2 mRNA

NCBI chr 1:52,937,823...52,961,307
Ensembl chr 1:52,937,917...52,961,307

G

tectonin beta-propeller repeat containing 1

decreases expression

clothianidin results in decreased expression of TECPR1 mRNA

NCBI chr12:10,391,587...10,420,462
Ensembl chr12:10,391,696...10,419,611

G

TEF transcription factor, PAR bZIP family member

increases expression

clothianidin results in increased expression of TEF mRNA

NCBI chr 7:113,317,191...113,341,783
Ensembl chr 7:113,317,283...113,341,783

G

transforming growth factor, beta induced

increases expression

clothianidin results in increased expression of TGFBI mRNA

NCBI chr17:7,955,603...7,984,903
Ensembl chr17:7,955,603...7,985,240

G

transglutaminase 5

decreases expression

clothianidin results in decreased expression of TGM5 mRNA

NCBI chr 3:108,008,087...108,044,013
Ensembl chr 3:108,008,143...108,043,976

G

thyroid hormone responsive

decreases expression

clothianidin results in decreased expression of THRSP mRNA

NCBI chr 1:151,723,415...151,727,740
Ensembl chr 1:151,723,086...151,728,075

G

TIR domain containing adaptor molecule 1

increases expression

clothianidin results in increased expression of TICAM1 mRNA

NCBI chr 9:1,102,559...1,111,023
Ensembl chr 9:1,102,366...1,123,147

G

TRAF-interacting protein with forkhead-associated domain

increases expression

clothianidin results in increased expression of TIFA mRNA

NCBI chr 2:216,257,926...216,267,635
Ensembl chr 2:216,234,774...216,267,841

G

TLC domain containing 4

increases expression

clothianidin results in increased expression of TLCD4 mRNA

NCBI chr 2:209,284,873...209,360,156
Ensembl chr 2:209,289,732...209,341,353

G

toll-like receptor 2

increases expression

clothianidin results in increased expression of TLR2 mRNA

NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630

G

T-cell leukemia, homeobox 3

decreases expression

clothianidin results in decreased expression of TLX3 mRNA

NCBI chr10:17,789,706...17,792,207
Ensembl chr10:17,790,053...17,792,207

G

transmembrane protein 273

increases expression

clothianidin results in increased expression of TMEM273 mRNA

NCBI chr16:8,049,565...8,081,981
Ensembl chr16:8,049,669...8,081,981

G

transmembrane protein 38a

decreases expression

clothianidin results in decreased expression of TMEM38A mRNA

NCBI chr16:17,258,160...17,274,204
Ensembl chr16:17,258,164...17,273,415

G

transmembrane protein 71

decreases expression

clothianidin results in decreased expression of TMEM71 mRNA

NCBI chr 7:98,276,975...98,323,161
Ensembl chr 7:98,276,975...98,315,858

G

thiol methyltransferase 1A

decreases expression

clothianidin results in decreased expression of TMT1A mRNA

NCBI chr 7:131,452,099...131,460,154
Ensembl chr 7:131,451,641...131,460,154

G

tumor necrosis factor

multiple interactions

clothianidin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; clothianidin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor superfamily member 11B

decreases expression

clothianidin results in decreased expression of TNFRSF11B mRNA

NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538

G

tenascin XB

decreases expression

clothianidin results in decreased expression of TNXB mRNA

G

tropomyosin 1

increases expression

clothianidin results in increased expression of TPM1 mRNA

NCBI chr 8:67,635,479...67,662,330
Ensembl chr 8:67,635,479...67,662,802

G

Tnf receptor associated factor 4

increases expression

clothianidin results in increased expression of TRAF4 mRNA

NCBI chr10:63,054,169...63,060,284
Ensembl chr10:63,054,181...63,060,284

G

TNF receptor associated factor 6

decreases expression

clothianidin results in decreased expression of TRAF6 mRNA

NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507

G

trafficking protein particle complex subunit 4

increases expression

clothianidin results in increased expression of TRAPPC4 mRNA

NCBI chr 8:44,729,458...44,733,285
Ensembl chr 8:44,725,331...44,733,491

G

tripartite motif-containing 37

decreases expression

clothianidin results in decreased expression of TRIM37 mRNA

NCBI chr10:71,943,384...72,075,563
Ensembl chr10:71,943,375...72,075,558

G

tRNA methyltransferase 44

increases expression

clothianidin results in increased expression of TRMT44 mRNA

NCBI chr14:75,175,331...75,204,291
Ensembl chr14:75,182,029...75,200,147

G

testis-specific serine kinase 6

decreases expression

clothianidin results in decreased expression of TSSK6 mRNA

NCBI chr16:19,523,626...19,526,074
Ensembl chr16:19,517,334...19,526,090

G

tetratricopeptide repeat domain 28

decreases expression

clothianidin results in decreased expression of TTC28 mRNA

NCBI chr12:45,342,986...45,783,968
Ensembl chr12:45,345,399...45,783,547

G

tetratricopeptide repeat domain 33

decreases expression

clothianidin results in decreased expression of TTC33 mRNA

NCBI chr 2:54,279,906...54,326,851
Ensembl chr 2:54,279,997...54,323,871

G

tetratricopeptide repeat domain 8

decreases expression

clothianidin results in decreased expression of TTC8 mRNA

NCBI chr 6:118,198,186...118,252,422
Ensembl chr 6:118,198,201...118,252,418

G

tubulin gamma complex component 3

increases expression

clothianidin results in increased expression of TUBGCP3 mRNA

NCBI chr16:76,851,859...76,912,499
Ensembl chr16:76,851,810...76,912,499

G

thioredoxin domain containing 2

increases expression

clothianidin results in increased expression of TXNDC2 mRNA

NCBI chr 9:105,230,575...105,235,131
Ensembl chr 9:105,230,578...105,235,126

G

ubiquitin associated protein 1-like

decreases expression
increases expression

clothianidin results in decreased expression of UBAP1L mRNA
clothianidin results in increased expression of UBAP1L mRNA

PMID:29044138 PMID:31626844

NCBI chr 8:65,877,488...65,897,593
Ensembl chr 8:65,884,729...65,897,593

G

unc-119 lipid binding chaperone B

increases expression

clothianidin results in increased expression of UNC119B mRNA

NCBI chr12:41,478,808...41,491,432
Ensembl chr12:41,478,808...41,491,432

G

ubiquitin specific peptidase 43

decreases expression

clothianidin results in decreased expression of USP43 mRNA

NCBI chr10:52,549,200...52,611,168
Ensembl chr10:52,548,963...52,611,533

G

utrophin

decreases expression

clothianidin results in decreased expression of UTRN mRNA

NCBI chr 1:6,720,854...7,224,313
Ensembl chr 1:6,722,594...7,224,313

G

vesicle-associated membrane protein 8

increases expression

clothianidin results in increased expression of VAMP8 mRNA

NCBI chr 4:104,442,383...104,452,884
Ensembl chr 4:104,442,393...104,452,897

G

vascular endothelial growth factor D

decreases expression

clothianidin results in decreased expression of VEGFD mRNA

NCBI chr X:30,073,122...30,108,413
Ensembl chr X:30,074,163...30,108,295

G

VPS8 subunit of CORVET complex

decreases expression

clothianidin results in decreased expression of VPS8 mRNA

NCBI chr11:79,402,236...79,634,234
Ensembl chr11:79,402,239...79,634,133

G

WASH complex subunit 4

increases expression

clothianidin results in increased expression of WASHC4 mRNA

NCBI chr 7:20,187,905...20,240,228
Ensembl chr 7:20,187,922...20,240,226

G

whirlin

increases expression

clothianidin results in increased expression of WHRN mRNA

NCBI chr 5:76,828,308...76,911,945
Ensembl chr 5:76,828,301...76,912,223

G

Wnt family member 7B

decreases expression

clothianidin results in decreased expression of WNT7B mRNA

NCBI chr 7:116,634,817...116,679,459
Ensembl chr 7:116,634,814...116,679,581

G

yippee-like 2

increases expression

clothianidin results in increased expression of YPEL2 mRNA

NCBI chr10:71,746,308...71,803,843
Ensembl chr10:71,746,311...71,803,911

G

yippee-like 3

decreases expression

clothianidin results in decreased expression of YPEL3 mRNA

NCBI chr 1:181,384,385...181,387,706
Ensembl chr 1:181,384,357...181,387,705

G

zinc finger and BTB domain containing 45

decreases expression

clothianidin results in decreased expression of ZBTB45 mRNA

NCBI chr 1:73,634,895...73,639,802
Ensembl chr 1:73,635,448...73,639,556

G

zinc finger CCHC-type containing 13

decreases expression

clothianidin results in decreased expression of ZCCHC13 mRNA

NCBI chr X:68,643,568...68,644,671
Ensembl chr X:68,643,549...68,665,131

G

zinc finger protein 18

decreases expression

clothianidin results in decreased expression of ZNF18 mRNA

NCBI chr10:50,473,428...50,495,707
Ensembl chr10:50,473,483...50,495,706

G

zinc finger protein 219

decreases expression

clothianidin results in decreased expression of ZNF219 mRNA

NCBI chr15:24,695,831...24,710,039
Ensembl chr15:24,695,837...24,710,030

G

zinc finger protein 467

increases expression

clothianidin results in increased expression of ZNF467 mRNA

NCBI chr 4:77,385,752...77,394,709
Ensembl chr 4:77,385,758...77,392,229

G

zinc finger protein 470

increases expression

clothianidin results in increased expression of ZNF470 mRNA

NCBI chr 1:91,063,905...91,111,883
Ensembl chr 1:91,087,361...91,112,065

G

zinc finger protein 502

increases expression

clothianidin results in increased expression of ZNF502 mRNA

NCBI chr 1:28,884,390...28,908,726

G

zinc finger protein 521

decreases expression

clothianidin results in decreased expression of ZNF521 mRNA

NCBI chr18:4,775,952...5,068,592
Ensembl chr18:4,787,295...5,068,458

G

zinc finger protein 653

decreases expression

clothianidin results in decreased expression of ZNF653 mRNA

NCBI chr 8:20,586,607...20,605,439
Ensembl chr 8:20,586,563...20,604,864

G

zinc finger protein 865

increases expression

clothianidin results in increased expression of ZNF784 mRNA

NCBI chr 1:68,805,302...68,809,780
Ensembl chr 1:68,805,302...68,809,780

G

zinc finger with KRAB and SCAN domains 7

increases expression

clothianidin results in increased expression of ZKSCAN7 mRNA

NCBI chr 8:122,501,938...122,519,600
Ensembl chr 8:122,502,218...122,519,600

G

zinc finger, SWIM-type containing 4

decreases expression

clothianidin results in decreased expression of ZSWIM4 mRNA

NCBI chr19:23,927,845...23,952,970
Ensembl chr19:23,927,845...23,952,970

dinotefuran

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cholinergic receptor nicotinic beta 2 subunit

multiple interactions

dinotefuran results in increased activity of [NACHRA8 protein co-treated with CHRNB2 protein]; dinotefuran results in increased activity of [NACHRALPHA1 protein co-treated with CHRNB2 protein]

PMID:16981889 PMID:25459289

NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619

guanethidine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 4

decreases activity

Guanethidine results in decreased activity of ABCB4 protein

NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202

G

acid phosphatase 5, tartrate resistant

affects expression
increases expression

Guanethidine affects the expression of ACP5 protein
Guanethidine results in increased expression of ACP5 mRNA

NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929

G

cathepsin K

increases expression
affects expression

Guanethidine results in increased expression of CTSK mRNA
Guanethidine affects the expression of CTSK protein

NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions

Guanethidine inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A2 protein]

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

matrix metallopeptidase 13

increases expression

Guanethidine results in increased expression of MMP13 mRNA

NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239

G

neuropeptide Y

decreases expression
decreases secretion

Guanethidine results in decreased expression of NPY protein
Guanethidine results in decreased secretion of NPY protein

PMID:9460767 PMID:14527964 PMID:15003356

NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495

G

serpin family E member 1

multiple interactions

Guanethidine inhibits the reaction [Kainic Acid results in increased expression of SERPINE1 mRNA]

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

tyrosine hydroxylase

decreases expression

Guanethidine results in decreased expression of TH protein

NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767

G

vasoactive intestinal peptide

decreases expression

Guanethidine results in decreased expression of VIP protein

NCBI chr 1:42,064,878...42,073,219
Ensembl chr 1:42,065,120...42,073,216

N-methyl-N'-nitro-N-nitrosoguanidine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ABL proto-oncogene 1, non-receptor tyrosine kinase

multiple interactions

[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of ABL1 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of ABL1 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of ABL1 mRNA

NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065

G

acyl-CoA oxidase 2

decreases expression

Methylnitronitrosoguanidine results in decreased expression of ACOX2 mRNA

NCBI chr15:16,660,584...16,692,160
Ensembl chr15:16,660,272...16,692,160

G

ADAM metallopeptidase domain 10

increases expression

Methylnitronitrosoguanidine results in increased expression of ADAM10 mRNA

NCBI chr 8:71,346,008...71,477,889
Ensembl chr 8:71,345,837...71,477,889

G

angiotensinogen

multiple interactions

[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of AGT mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of AGT mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of AGT mRNA

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

apoptosis inducing factor, mitochondria associated 1

multiple interactions
increases localization

benzamide inhibits the reaction [Methylnitronitrosoguanidine results in increased localization of AIFM1 protein]; phenanthridone inhibits the reaction [Methylnitronitrosoguanidine results in increased localization of AIFM1 protein]

NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256

G

AKT serine/threonine kinase 1

increases expression
multiple interactions

Methylnitronitrosoguanidine results in increased expression of AKT1 mRNA
corilagin inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of AKT1 mRNA]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

albumin

decreases secretion

Methylnitronitrosoguanidine results in decreased secretion of ALB protein

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

aldehyde dehydrogenase 1 family, member A1

multiple interactions

[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of ALDH1A1 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of ALDH1A1 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of ALDH1A1 mRNA

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

alkaline phosphatase, biomineralization associated

increases expression

Methylnitronitrosoguanidine results in increased expression of ALPL mRNA

NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446

G

alpha-1-microglobulin/bikunin precursor

decreases expression

Methylnitronitrosoguanidine results in decreased expression of AMBP mRNA

NCBI chr 5:76,568,094...76,578,416
Ensembl chr 5:76,568,094...76,578,331

G

annexin A5

multiple interactions

[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of ANXA5 mRNA

NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369

G

apoptotic peptidase activating factor 1

affects response to substance
decreases expression
multiple interactions

APAF1 protein affects the susceptibility to Methylnitronitrosoguanidine
Methylnitronitrosoguanidine results in decreased expression of APAF1 protein
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of APAF1 protein]

PMID:16019050 PMID:20434464

NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540

G

APC regulator of WNT signaling pathway

increases expression

Methylnitronitrosoguanidine results in increased expression of APC mRNA

NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696

G

amyloid beta precursor protein

multiple interactions

[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of APP mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of APP mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of APP mRNA

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

A-Raf proto-oncogene, serine/threonine kinase

increases expression

Methylnitronitrosoguanidine results in increased expression of ARAF mRNA

NCBI chr X:1,227,392...1,292,356
Ensembl chr X:1,227,392...1,239,073

G

ATM serine/threonine kinase

increases response to substance

ATM gene mutant form results in increased susceptibility to Methylnitronitrosoguanidine

NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437

G

ATPase Na+/K+ transporting subunit beta 3

decreases expression

Methylnitronitrosoguanidine results in decreased expression of ATP1B3 mRNA

NCBI chr 8:96,910,265...96,941,592
Ensembl chr 8:96,910,309...96,941,598
Ensembl chr 8:96,910,309...96,941,598

G

ATR serine/threonine kinase

multiple interactions

ATR protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of E2F1 protein]; ATR protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of E2F3 protein]; ATR protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2 mRNA]; ATR protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2 protein]; ATR protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2B protein]; ATR protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of TP53 protein]

NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136

G

Axl receptor tyrosine kinase

increases expression

Methylnitronitrosoguanidine results in increased expression of AXL mRNA

NCBI chr 1:81,265,088...81,296,278
Ensembl chr 1:81,265,088...81,296,265

G

BCL2-associated agonist of cell death

decreases expression
decreases phosphorylation
multiple interactions

Methylnitronitrosoguanidine results in decreased expression of BAD mRNA
Methylnitronitrosoguanidine results in decreased phosphorylation of BAD protein
N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Methylnitronitrosoguanidine results in decreased phosphorylation of BAD protein]
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of BAD mRNA]

PMID:17828454 PMID:20434464

NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823

G

BAG cochaperone 1

increases expression

Methylnitronitrosoguanidine results in increased expression of BAG1 mRNA

NCBI chr 5:56,068,494...56,081,075
Ensembl chr 5:56,068,494...56,081,075

G

BCL2-antagonist/killer 1

multiple interactions

BAK1 protein results in increased susceptibility to [Methylnitronitrosoguanidine co-treated with veliparib]

NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264

G

BCL2 associated X, apoptosis regulator

multiple interactions
decreases expression

[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of BAX protein; corilagin inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of BAX protein]
Methylnitronitrosoguanidine results in decreased expression of BAX mRNA; Methylnitronitrosoguanidine results in decreased expression of BAX protein
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of BAX mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of BAX protein]
BAX protein results in increased susceptibility to [Methylnitronitrosoguanidine co-treated with veliparib]

PMID:16030430 PMID:18376143 PMID:20434464 PMID:35103375

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

branched chain amino acid transaminase 2

multiple interactions

[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of BCAT2 mRNA

NCBI chr 1:96,040,407...96,060,008
Ensembl chr 1:96,042,625...96,060,007

G

BCL2, apoptosis regulator

decreases expression
increases expression
multiple interactions

Methylnitronitrosoguanidine results in decreased expression of BCL2 protein
Methylnitronitrosoguanidine results in increased expression of BCL2 protein
weifuchun affects the reaction [Methylnitronitrosoguanidine results in increased expression of BCL2 protein]
Methylnitronitrosoguanidine results in increased expression of BCL2 mRNA; Methylnitronitrosoguanidine results in increased expression of BCL2 protein
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of BCL2 mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of BCL2 protein]
[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in increased expression of BCL2 protein; [S-allylcysteine co-treated with Lycopene] inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in increased expression of BCL2 protein]; corilagin inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of BCL2 protein]; Lycopene inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in increased expression of BCL2 protein]; S-allylcysteine inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in increased expression of BCL2 protein]; weifuchun inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of BCL2 protein]

PMID:16019050 PMID:16030430 PMID:20434464 PMID:35103375 PMID:36403744

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

multiple interactions
increases expression

BCL2L1 protein results in decreased susceptibility to [Methylnitronitrosoguanidine co-treated with veliparib]
Methylnitronitrosoguanidine results in increased expression of BCL2L1 mRNA
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of BCL2L1 mRNA]

PMID:18376143 PMID:20434464

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

G

Bcl2-like 11

multiple interactions

[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of BCL2L11 protein; S-allylcysteine inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of BCL2L11 protein]

NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068

G

brain-derived neurotrophic factor

increases expression

Methylnitronitrosoguanidine results in increased expression of BDNF mRNA

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

biglycan

multiple interactions

[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of BGN mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of BGN mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of BGN mRNA

NCBI chr X:151,197,296...151,209,458
Ensembl chr X:151,197,273...151,209,461

G

BH3 interacting domain death agonist

multiple interactions
decreases expression

Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of BID mRNA]

NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720

G

baculoviral IAP repeat-containing 2

increases expression

Methylnitronitrosoguanidine results in increased expression of BIRC2 mRNA

NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732

G

biliverdin reductase B

multiple interactions

[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of BLVRB mRNA

NCBI chr 1:82,738,646...82,756,312
Ensembl chr 1:82,738,695...82,770,375

G

bone morphogenetic protein 4

decreases expression

Methylnitronitrosoguanidine results in decreased expression of BMP4 mRNA

NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306

G

BRCA1, DNA repair associated

increases expression

Methylnitronitrosoguanidine results in increased expression of BRCA1 mRNA

NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304

G

BRCA2, DNA repair associated

increases expression

Methylnitronitrosoguanidine results in increased expression of BRCA2 mRNA

NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567

G

basigin

multiple interactions
increases expression

corilagin inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of BSG mRNA]

NCBI chr 7:9,993,170...10,000,387
Ensembl chr 7:9,993,170...10,000,387

G

BTG anti-proliferation factor 2

decreases expression

Methylnitronitrosoguanidine results in decreased expression of BTG2 protein

NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628

G

complement C1q B chain

increases expression

Methylnitronitrosoguanidine results in increased expression of C1QB mRNA

NCBI chr 5:149,118,843...149,124,394
Ensembl chr 5:149,118,846...149,124,407

G

complement C1s

increases expression

Methylnitronitrosoguanidine results in increased expression of C1S mRNA

NCBI chr 4:157,430,249...157,442,438
Ensembl chr 4:157,430,117...157,442,303

G

calmodulin 1

multiple interactions

[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of CALM1 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of CALM1 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CALM1 mRNA

NCBI chr 6:119,487,691...119,495,759
Ensembl chr 6:119,487,621...119,498,227

G

caspase 3

increases activity
decreases expression
multiple interactions

Methylnitronitrosoguanidine results in increased activity of CASP3 protein
Methylnitronitrosoguanidine results in decreased expression of CASP3 protein
Methylnitronitrosoguanidine results in decreased expression of CASP3 mRNA; Methylnitronitrosoguanidine results in decreased expression of CASP3 protein
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CASP3 mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CASP3 protein]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride promotes the reaction [Methylnitronitrosoguanidine results in increased activity of CASP3 protein]
[Methylnitronitrosoguanidine co-treated with N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride] results in increased activity of CASP3 protein; [Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP3 protein; [S-allylcysteine co-treated with Lycopene] inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP3 protein]; corilagin inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CASP3 protein]

PMID:15589979 PMID:16019050 PMID:16030430 PMID:17428624 PMID:20434464 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

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caspase 4

increases expression

Methylnitronitrosoguanidine results in increased expression of CASP4 mRNA

NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092

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caspase 8

multiple interactions

[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP8 protein; [S-allylcysteine co-treated with lycopene] inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP8 protein]; lycopene inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP8 protein]; S-allylcysteine inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP8 protein]

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

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caspase 9

increases activity
decreases expression
multiple interactions

Methylnitronitrosoguanidine results in increased activity of CASP9 protein
Methylnitronitrosoguanidine results in decreased expression of CASP9 protein
corilagin inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CASP9 protein]
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CASP9 protein]

PMID:15589979 PMID:16019050 PMID:20434464 PMID:35103375

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

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catalase

multiple interactions
decreases activity

corilagin inhibits the reaction [Methylnitronitrosoguanidine results in decreased activity of CAT protein]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

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chromobox 5

decreases expression

Methylnitronitrosoguanidine results in decreased expression of CBX5 mRNA

NCBI chr 7:134,333,165...134,376,102
Ensembl chr 7:134,331,335...134,375,022

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cyclin A1

increases expression

Methylnitronitrosoguanidine results in increased expression of CCNA1 mRNA

NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157

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cyclin B1

multiple interactions
decreases expression
increases expression

Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of CCNB1 mRNA]
Methylnitronitrosoguanidine results in decreased expression of CCNB1 mRNA
[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of CCNB1 mRNA

PMID:11516527 PMID:12135628 PMID:19851710

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

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cyclin D1

multiple interactions
increases expression

Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of CCND1 mRNA]
[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of CCND1 protein
Methylnitronitrosoguanidine results in increased expression of CCND1 mRNA; Methylnitronitrosoguanidine results in increased expression of CCND1 protein

PMID:12135628 PMID:19851710 PMID:21628965

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

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cyclin G1

increases expression

Methylnitronitrosoguanidine results in increased expression of CCNG1 mRNA

NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641

G

cyclin H

increases expression

Methylnitronitrosoguanidine results in increased expression of CCNH mRNA

NCBI chr 2:15,835,064...15,855,648
Ensembl chr 2:15,834,833...15,855,819

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chaperonin containing TCP1 subunit 2

multiple interactions

[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of CCT2 mRNA

NCBI chr 7:52,692,725...52,705,478
Ensembl chr 7:52,692,725...52,706,944

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CD14 molecule

increases expression
multiple interactions

Methylnitronitrosoguanidine results in increased expression of CD14 protein
weifuchun inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of CD14 protein]

NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261

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CD59b molecule

increases mutagenesis

Methylnitronitrosoguanidine results in increased mutagenesis of CD59 protein

NCBI chr 3:90,459,085...90,477,571
Ensembl chr 3:90,459,162...90,478,847

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CD9 molecule

multiple interactions

[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of CD9 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of CD9 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CD9 mRNA

NCBI chr 4:158,256,328...158,289,136
Ensembl chr 4:158,256,328...158,289,222

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cadherin 1

multiple interactions
decreases expression

geraniol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CDH1 protein]
Methylnitronitrosoguanidine results in decreased expression of CDH1 mRNA
KLF7 protein promotes the reaction [Methylnitronitrosoguanidine results in decreased expression of CDH1 mRNA]
KLF7 protein inhibits the reaction [MIR520F inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CDH1 mRNA]]; KLF7 protein inhibits the reaction [MIR520F inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CDH1 protein]]; MIR520F inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CDH1 mRNA]; MIR520F inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CDH1 protein]
Methylnitronitrosoguanidine results in decreased expression of CDH1 mRNA; Methylnitronitrosoguanidine results in decreased expression of CDH1 protein

PMID:28428697 PMID:38184286

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

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cadherin 2

increases expression
multiple interactions

Methylnitronitrosoguanidine results in increased expression of CDH2 mRNA
KLF7 protein inhibits the reaction [MIR520F inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of CDH2 mRNA]]; KLF7 protein inhibits the reaction [MIR520F inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of CDH2 protein]]; MIR520F inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of CDH2 mRNA]; MIR520F inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of CDH2 protein]
Methylnitronitrosoguanidine results in increased expression of CDH2 mRNA; Methylnitronitrosoguanidine results in increased expression of CDH2 protein
KLF7 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of CDH2 mRNA]

NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167

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cadherin 8

decreases expression

Methylnitronitrosoguanidine results in decreased expression of CDH8 mRNA

NCBI chr19:5,494,038...5,901,810
Ensembl chr19:5,494,174...5,895,669

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cyclin-dependent kinase 4

increases expression
multiple interactions

Methylnitronitrosoguanidine results in increased expression of CDK4 protein
weifuchun inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of CDK4 protein]
[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of CDK4 protein

PMID:12135628 PMID:21628965 PMID:36403744

NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403

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cyclin-dependent kinase 5

increases expression

Methylnitronitrosoguanidine results in increased expression of CDK5 mRNA

NCBI chr 4:10,754,682...10,760,110
Ensembl chr 4:10,754,687...10,760,112

G

cyclin-dependent kinase inhibitor 1A

decreases expression
multiple interactions

Methylnitronitrosoguanidine results in decreased expression of CDKN1A mRNA
Methylnitronitrosoguanidine results in decreased expression of CDKN1A protein
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CDKN1A protein]

PMID:12634122 PMID:19851710

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

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cyclin-dependent kinase inhibitor 1B

decreases expression
multiple interactions
increases expression

Methylnitronitrosoguanidine results in decreased expression of CDKN1B mRNA
Cadmium Chloride inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of CDKN1B protein]; Cadmium Chloride promotes the reaction [Methylnitronitrosoguanidine results in decreased expression of CDKN1B mRNA]

PMID:11516527 PMID:12135628

NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982

G

centrosomal protein 43

increases expression

Methylnitronitrosoguanidine results in increased expression of CEP43 mRNA

NCBI chr 1:52,533,418...52,564,025
Ensembl chr 1:52,533,428...52,563,923

G

checkpoint kinase 1

multiple interactions

CHEK1 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of E2F3 protein]; CHEK1 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2 mRNA]; CHEK1 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2 protein]

NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009

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checkpoint kinase 2

multiple interactions

CHEK2 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of E2F1 protein]; CHEK2 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2B protein]; CHEK2 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of TP53 protein]

NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286

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creatine kinase B

decreases expression

Methylnitronitrosoguanidine results in decreased expression of CKB mRNA

NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315

G

clathrin, light chain A

multiple interactions

[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of CLTA mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of CLTA mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CLTA mRNA

NCBI chr 5:58,244,253...58,263,480
Ensembl chr 5:58,245,442...58,263,472

G

collagen type I alpha 2 chain

multiple interactions

[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of COL1A2 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of COL1A2 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of COL1A2 mRNA

NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867

G

collagen type VI alpha 1 chain

multiple interactions

[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of COL6A1 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of COL6A1 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of COL6A1 mRNA

NCBI chr20:11,906,105...11,924,599
Ensembl chr20:11,905,957...11,924,597

G

collagen type VIII alpha 1 chain

multiple interactions

[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of COL8A1 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of COL8A1 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of COL8A1 mRNA

NCBI chr11:42,776,851...42,906,432
Ensembl chr11:42,777,628...42,906,424

G

cytochrome c oxidase subunit 6A1

multiple interactions

[Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of COX6A1 mRNA

NCBI chr12:41,261,983...41,265,037
Ensembl chr12:41,261,967...41,265,041

G

cytochrome c oxidase subunit 8A

multiple interactions

[Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of COX8A mRNA

NCBI chr 1:204,402,118...204,404,439

G

catenin beta 1

multiple interactions
increases expression

geraniol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of CTNNB1 mRNA]

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

cathepsin B

multiple interactions

[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of CTSB mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of CTSB mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of CTSB mRNA

NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500

G

cathepsin L

multiple interactions

[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of CTSL mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of CTSL mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CTSL mRNA

NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548

G

C-X-C motif chemokine ligand 12

multiple interactions

[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of CXCL12 mRNA

NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168

G

C-X-C motif chemokine receptor 4

decreases expression

Methylnitronitrosoguanidine results in decreased expression of CXCR4 mRNA

NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883

G

cytochrome b561 family, member D2

decreases expression

Methylnitronitrosoguanidine results in decreased expression of CYB561D2 mRNA

NCBI chr 8:108,213,201...108,215,778
Ensembl chr 8:108,213,205...108,215,759

G

cytochrome c, somatic

multiple interactions
decreases expression

Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CYCS mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CYCS protein]
Methylnitronitrosoguanidine results in decreased expression of CYCS mRNA; Methylnitronitrosoguanidine results in decreased expression of CYCS protein

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

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DAB adaptor protein 2

increases expression

Methylnitronitrosoguanidine results in increased expression of DAB2 mRNA

PMID:12634122 PMID:12773770

NCBI chr 2:55,514,692...55,567,476
Ensembl chr 2:55,514,700...55,567,476

G

decorin

decreases expression

Methylnitronitrosoguanidine results in decreased expression of DCN mRNA

NCBI chr 7:32,281,252...32,321,291
Ensembl chr 7:32,281,252...32,321,270

G

DEAF1 transcription factor

decreases expression

Methylnitronitrosoguanidine results in decreased expression of DEAF1 mRNA

NCBI chr 1:196,401,857...196,435,541
Ensembl chr 1:196,401,857...196,435,541

G

DEK proto-oncogene

increases expression

Methylnitronitrosoguanidine results in increased expression of DEK mRNA

NCBI chr17:17,580,804...17,602,825
Ensembl chr17:17,580,843...17,602,808

G

discs large MAGUK scaffold protein 1

multiple interactions

[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of DLG1 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of DLG1 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of DLG1 mRNA

NCBI chr11:68,911,883...69,103,230
Ensembl chr11:68,911,883...69,102,689

G

destrin, actin depolymerizing factor

increases expression

Methylnitronitrosoguanidine results in increased expression of DSTN mRNA

NCBI chr 3:131,284,647...131,311,361
Ensembl chr 3:131,284,648...131,311,379

G

deoxyuridine triphosphatase

affects localization
increases secretion

Methylnitronitrosoguanidine affects the localization of DUT protein
Methylnitronitrosoguanidine results in increased secretion of DUT protein

NCBI chr 3:112,498,864...112,509,994
Ensembl chr 3:112,498,982...112,510,771

G

E2F transcription factor 1

increases expression
multiple interactions

Methylnitronitrosoguanidine results in increased expression of E2F1 protein
ATR protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of E2F1 protein]; CHEK2 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of E2F1 protein]; E2F1 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2B mRNA]; Methylnitronitrosoguanidine promotes the reaction [E2F1 protein binds to RRM2 promoter]; Methylnitronitrosoguanidine promotes the reaction [E2F1 protein results in increased expression of RRM2 mRNA]

NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361

G

E2F transcription factor 3

multiple interactions

[[Methylnitronitrosoguanidine results in increased phosphorylation of and results in increased stability of and results in increased expression of E2F3 protein] which results in increased expression of RRM2 mRNA] inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of H2AX protein modified form]; [Methylnitronitrosoguanidine results in increased phosphorylation of and results in increased stability of and results in increased expression of E2F3 protein] which results in increased expression of RRM2 mRNA; ATR protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of E2F3 protein]; CHEK1 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of E2F3 protein]; CHIR-124 inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of E2F3 protein]; E2F3 protein inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of H2AX protein modified form]; E2F3 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2 mRNA]; E2F3 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2 protein]; E2F3 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2B mRNA]; Methylnitronitrosoguanidine promotes the reaction [E2F3 protein binds to RRM2 promoter]; Methylnitronitrosoguanidine promotes the reaction [E2F3 protein results in increased expression of RRM2 mRNA]; Methylnitronitrosoguanidine results in increased phosphorylation of and results in increased stability of and results in increased expression of E2F3 protein; NFYB protein promotes the reaction [Methylnitronitrosoguanidine promotes the reaction [E2F3 protein binds to RRM2 promoter]]; NFYB protein promotes the reaction [Methylnitronitrosoguanidine promotes the reaction [E2F3 protein results in increased expression of RRM2 mRNA]]

NCBI chr17:34,601,756...34,679,139
Ensembl chr17:34,601,830...34,676,253

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epidermal growth factor

affects activity
multiple interactions

Methylnitronitrosoguanidine affects the activity of EGF protein
Methylnitronitrosoguanidine inhibits the reaction [EGF protein results in increased activity of HRAS protein]; Methylnitronitrosoguanidine inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]

NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064

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epidermal growth factor receptor

affects localization
multiple interactions

Methylnitronitrosoguanidine affects the localization of EGFR protein
Methylnitronitrosoguanidine inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

early growth response 1

multiple interactions

[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of EGR1 mRNA

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

eukaryotic translation initiation factor 1

multiple interactions

[Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of EIF1 mRNA

NCBI chr10:85,246,751...85,248,842
Ensembl chr10:85,246,764...85,427,327
Ensembl chr 5:85,246,764...85,427,327

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eukaryotic translation initiation factor 3 subunit E

increases expression

Methylnitronitrosoguanidine results in increased expression of EIF3E mRNA

NCBI chr 7:74,339,848...74,372,483
Ensembl chr 7:74,339,828...74,373,096

G

eukaryotic translation initiation factor 5

decreases expression

Methylnitronitrosoguanidine results in decreased expression of EIF5 mRNA

NCBI chr 6:130,589,162...130,597,656
Ensembl chr 6:130,589,143...130,597,656

G

eukaryotic translation initiation factor 5A

multiple interactions

[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of EIF5A mRNA

NCBI chr10:54,640,104...54,644,845
Ensembl chr10:54,640,024...54,644,656

G

ETS transcription factor ELK3

increases expression

Methylnitronitrosoguanidine results in increased expression of ELK3 mRNA

NCBI chr 7:27,768,582...27,831,088
Ensembl chr 7:27,768,599...27,804,084

G

epithelial membrane protein 1

increases expression

Methylnitronitrosoguanidine results in increased expression of EMP1 mRNA

NCBI chr 4:168,212,901...168,233,039
Ensembl chr 4:168,212,861...168,232,904

G

ectonucleotide pyrophosphatase/phosphodiesterase 2

increases expression

Methylnitronitrosoguanidine results in increased expression of ENPP2 mRNA

NCBI chr 7:86,202,345...86,325,050
Ensembl chr 7:86,202,350...86,324,827

G

epithelial cell adhesion molecule

increases expression

Methylnitronitrosoguanidine results in increased expression of EPCAM mRNA

NCBI chr 6:6,880,142...6,896,103
Ensembl chr 6:6,878,237...6,896,127

G

Eph receptor A1

increases expression

Methylnitronitrosoguanidine results in increased expression of EPHA1 mRNA

NCBI chr 4:71,246,409...71,260,920
Ensembl chr 4:71,246,409...71,260,846

G

Eph receptor B3

decreases expression

Methylnitronitrosoguanidine results in decreased expression of EPHB3 mRNA

NCBI chr11:79,840,668...79,859,345
Ensembl chr11:79,840,668...79,859,370

G

EGFR pathway substrate 8, signaling adaptor

multiple interactions

[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of EPS8 mRNA

NCBI chr 4:170,388,378...170,486,873
Ensembl chr 4:170,388,378...170,486,873

G

erb-b2 receptor tyrosine kinase 2

increases expression

Methylnitronitrosoguanidine results in increased expression of ERBB2 mRNA

NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078

G

erb-b2 receptor tyrosine kinase 4

increases expression

Methylnitronitrosoguanidine results in increased expression of ERBB4 mRNA

NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595

G

estrogen receptor 2

increases expression

Methylnitronitrosoguanidine results in increased expression of ESR2 mRNA; Methylnitronitrosoguanidine results in increased expression of ESR2 protein

PMID:21628965 PMID:22330348

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

ETS proto-oncogene 1, transcription factor

increases expression

Methylnitronitrosoguanidine results in increased expression of ETS1 mRNA

NCBI chr 8:31,045,909...31,168,010
Ensembl chr 8:31,045,945...31,168,010

G

Fas ligand

decreases expression

Methylnitronitrosoguanidine results in decreased expression of FASLG protein

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

fatty acid synthase

increases expression

Methylnitronitrosoguanidine results in increased expression of FASN mRNA

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

G

FAU ubiquitin like and ribosomal protein S30 fusion

multiple interactions

[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of FAU mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of FAU mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of FAU mRNA

NCBI chr 1:203,350,226...203,351,741
Ensembl chr 1:203,350,189...203,351,742
Ensembl chr 1:203,350,189...203,351,742
Ensembl chr 6:203,350,189...203,351,742

G

Fc epsilon receptor Ia

increases expression

Methylnitronitrosoguanidine results in increased expression of FCER1A mRNA

NCBI chr13:85,686,099...85,692,394
Ensembl chr13:85,686,092...85,692,351

G

Fc gamma receptor 2A

increases expression

Methylnitronitrosoguanidine results in increased expression of FCGR3 mRNA

NCBI chr13:83,280,782...83,297,535
Ensembl chr13:83,280,784...83,295,967

G

Fc gamma receptor and transporter

decreases expression

Methylnitronitrosoguanidine results in decreased expression of FCGRT mRNA

NCBI chr 1:95,574,436...95,584,171
Ensembl chr 1:95,567,175...95,584,084

G

FES proto-oncogene, tyrosine kinase

increases expression

Methylnitronitrosoguanidine results in increased expression of FES mRNA

NCBI chr 1:134,337,698...134,346,934
Ensembl chr 1:134,337,698...134,346,934

G

fibroblast growth factor 10

increases expression

Methylnitronitrosoguanidine results in increased expression of FGF10 mRNA

NCBI chr 2:50,801,171...50,878,218
Ensembl chr 2:50,800,992...50,876,866

G

Fms related receptor tyrosine kinase 1

multiple interactions
increases expression

Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of FLT1 mRNA]

NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626

G

folate receptor alpha

increases methylation

Methylnitronitrosoguanidine results in increased methylation of FOLR1 promoter

NCBI chr 1:156,219,460...156,238,436
Ensembl chr 1:156,219,460...156,230,667

G

FOS like 1, AP-1 transcription factor subunit

decreases expression
multiple interactions

Methylnitronitrosoguanidine results in decreased expression of FOSL1 mRNA
Methylnitronitrosoguanidine promotes the reaction [[FOSL1 protein binds to JUNB protein] which binds to RRM2 promoter]; Methylnitronitrosoguanidine promotes the reaction [[FOSL1 protein binds to JUNB protein] which results in increased expression of RRM2 mRNA]; Methylnitronitrosoguanidine promotes the reaction [FOSL1 protein binds to RRM2 promoter]; Methylnitronitrosoguanidine promotes the reaction [FOSL1 protein results in increased expression of RRM2 mRNA]

PMID:12634122 PMID:26921499

NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930

G

follistatin

increases expression

Methylnitronitrosoguanidine results in increased expression of FST mRNA

NCBI chr 2:46,123,260...46,130,584
Ensembl chr 2:46,123,439...46,130,571

G

follistatin-like 1

multiple interactions

[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of FSTL1 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of FSTL1 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of FSTL1 mRNA

NCBI chr11:62,895,391...62,948,581
Ensembl chr11:62,779,783...62,948,677

G

FYN proto-oncogene, Src family tyrosine kinase

increases expression

Methylnitronitrosoguanidine results in increased expression of FYN mRNA

NCBI chr20:42,767,733...42,960,903
Ensembl chr20:42,766,369...42,959,911

G

growth arrest and DNA-damage-inducible, alpha

decreases expression
multiple interactions

Methylnitronitrosoguanidine results in decreased expression of GADD45A mRNA
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of GADD45A mRNA]

NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115

G

glucagon receptor

decreases expression

Methylnitronitrosoguanidine results in decreased expression of GCGR mRNA

NCBI chr10:105,808,474...105,816,641
Ensembl chr10:105,808,473...105,816,640

G

growth differentiation factor 15

increases expression

Methylnitronitrosoguanidine results in increased expression of GDF15 mRNA

PMID:12634122 PMID:12773770

NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055

G

gap junction protein, alpha 1

multiple interactions

[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of GJA1 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of GJA1 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of GJA1 mRNA

NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582

G

gap junction protein, beta 2

increases expression

Methylnitronitrosoguanidine results in increased expression of GJB2 mRNA

NCBI chr15:31,260,390...31,278,222
Ensembl chr15:31,260,357...31,278,177

G

GLI family zinc finger 1

increases expression

MNNG increases expression of Gli1 mRNA in rat stomach

RGD

NCBI chr 7:63,156,926...63,169,579
Ensembl chr 7:63,156,926...63,169,251

G

glypican 4

multiple interactions

[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of GPC4 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of GPC4 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of GPC4 mRNA

NCBI chr X:131,644,711...131,755,349
Ensembl chr X:131,644,704...131,755,284

G

glutathione synthetase

decreases expression

Methylnitronitrosoguanidine results in decreased expression of GSS mRNA

NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198

G

glutathione S-transferase mu 2

multiple interactions

[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of GSTM2 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of GSTM2 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of GSTM2 mRNA

NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961

G

glutathione S-transferase omega 1

multiple interactions

[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of GSTO1 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of GSTO1 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of GSTO1 mRNA

NCBI chr 1:246,721,089...246,731,228
Ensembl chr 1:246,721,221...246,731,468

G

glutathione S-transferase pi 1

multiple interactions

[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of GSTP1 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of GSTP1 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of GSTP1 mRNA

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

general transcription factor II I

multiple interactions

Methylnitronitrosoguanidine promotes the reaction [GTF2I protein binds to RRM2 promoter]

NCBI chr12:22,400,933...22,476,243
Ensembl chr12:22,401,431...22,476,243

G

H2A.X variant histone

increases expression
multiple interactions

Methylnitronitrosoguanidine results in increased expression of H2AX protein modified form
[[Methylnitronitrosoguanidine results in increased phosphorylation of and results in increased stability of and results in increased expression of E2F3 protein] which results in increased expression of RRM2 mRNA] inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of H2AX protein modified form]; E2F3 protein inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of H2AX protein modified form]; RRM2 protein inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of H2AX protein modified form]

PMID:26921499 PMID:27233451

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239

G

H4 clustered histone 14

decreases expression

Methylnitronitrosoguanidine results in decreased expression of H4C2 mRNA

NCBI chr 2:183,831,601...183,831,996
Ensembl chr 2:183,825,994...183,832,048

G

hemoglobin alpha, adult chain 2

increases expression

Methylnitronitrosoguanidine results in increased expression of HBA1 mRNA

NCBI chr10:15,323,830...15,324,677
Ensembl chr10:15,307,815...15,338,392
Ensembl chr10:15,307,815...15,338,392

G

hes family bHLH transcription factor 1

increases expression
multiple interactions

Methylnitronitrosoguanidine results in increased expression of HES1 protein
weifuchun inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of HES1 protein]

NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192

G

hes family bHLH transcription factor 6

multiple interactions
increases expression

weifuchun inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of HES6 protein]

NCBI chr 9:92,001,849...92,003,562
Ensembl chr 9:92,001,841...92,003,559

G

hypoxia inducible factor 1 subunit alpha

increases expression
multiple interactions

Methylnitronitrosoguanidine results in increased expression of HIF1A mRNA; Methylnitronitrosoguanidine results in increased expression of HIF1A protein
corilagin inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of HIF1A mRNA]; weifuchun inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of HIF1A protein]

PMID:35103375 PMID:36403744

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

high mobility group box 1

increases expression
multiple interactions

Methylnitronitrosoguanidine results in increased expression of HMGB1 mRNA
corilagin inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of HMGB1 mRNA]

PMID:12634122 PMID:35103375

NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565

G

high mobility group box 2

decreases expression

Methylnitronitrosoguanidine results in decreased expression of HMGB2 mRNA

NCBI chr16:32,710,651...32,713,230
Ensembl chr16:32,710,658...32,713,140
Ensembl chr 1:32,710,658...32,713,140

G

15-hydroxyprostaglandin dehydrogenase

decreases expression

Methylnitronitrosoguanidine results in decreased expression of HPGD mRNA

NCBI chr16:33,986,265...34,024,228
Ensembl chr16:33,986,266...34,024,228

G

hypoxanthine phosphoribosyltransferase 1

multiple interactions

[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of HPRT1 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of HPRT1 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of HPRT1 mRNA

NCBI chr X:132,736,175...132,768,149
Ensembl chr X:132,736,096...132,768,154

G

HRas proto-oncogene, GTPase

multiple interactions

Methylnitronitrosoguanidine inhibits the reaction [EGF protein results in increased activity of HRAS protein]

NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615

G

heat shock protein 90 alpha family class A member 1

multiple interactions

[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of HSP90AA1 mRNA

NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268

G

heat shock protein 90 alpha family class B member 1

multiple interactions

[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of HSP90AB1 mRNA

NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488

G

heat shock protein 90 beta family member 1

increases expression

Methylnitronitrosoguanidine results in increased expression of HSP90B1 mRNA

NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788

G

heat shock protein family A (Hsp70) member 1A

decreases expression

Methylnitronitrosoguanidine results in decreased expression of HSPA1A mRNA

NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227

G

heat shock protein family D (Hsp60) member 1

multiple interactions

[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of HSPD1 mRNA

NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662

G

intercellular adhesion molecule 1

decreases response to substance
multiple interactions
increases expression

ICAM1 protein results in decreased susceptibility to Methylnitronitrosoguanidine
prolinedithiocarbamate inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of ICAM1 protein]
Methylnitronitrosoguanidine results in increased expression of ICAM1 mRNA; Methylnitronitrosoguanidine results in increased expression of ICAM1 protein

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

inhibitor of DNA binding 1

decreases expression

Methylnitronitrosoguanidine results in decreased expression of ID1 mRNA

NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419

G

immediate early response 3

multiple interactions

[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of IER3 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of IER3 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IER3 mRNA

NCBI chr20:2,928,378...2,929,582
Ensembl chr20:2,928,378...2,929,583

G

interferon induced transmembrane protein 1

increases expression

Methylnitronitrosoguanidine results in increased expression of IFITM1 mRNA

PMID:12634122 PMID:12773770

NCBI chr 1:196,067,163...196,069,169
Ensembl chr 1:196,067,963...196,069,169

G

interferon-related developmental regulator 1

increases expression

Methylnitronitrosoguanidine results in increased expression of IFRD1 mRNA

NCBI chr 6:57,269,395...57,317,833
Ensembl chr 6:57,269,384...57,288,990

G

immunoglobulin kappa constant

increases expression

Methylnitronitrosoguanidine results in increased expression of IGKC mRNA

G

immunoglobulin superfamily, member 6

increases expression

Methylnitronitrosoguanidine results in increased expression of IGSF6 mRNA

NCBI chr 1:175,610,167...175,620,662
Ensembl chr 1:175,610,167...175,620,722

G

inhibitor of nuclear factor kappa B kinase subunit beta

multiple interactions
increases expression

Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of IKBKB protein]

NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250

G

interleukin 1 beta

increases secretion
multiple interactions

Methylnitronitrosoguanidine results in increased secretion of IL1B protein
KLF7 protein promotes the reaction [Methylnitronitrosoguanidine results in increased secretion of IL1B protein]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions
increases secretion
increases expression

weifuchun inhibits the reaction [Methylnitronitrosoguanidine results in increased secretion of IL6 protein]
KLF7 protein promotes the reaction [Methylnitronitrosoguanidine results in increased secretion of IL6 protein]
weifuchun inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of IL6 protein]

PMID:36403744 PMID:38184286

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

interleukin-1 receptor-associated kinase 1

multiple interactions

[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of IRAK1 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of IRAK1 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IRAK1 mRNA

NCBI chr X:151,768,621...151,778,521
Ensembl chr X:151,768,777...151,778,521

G

integrin subunit beta 4

decreases expression

Methylnitronitrosoguanidine results in decreased expression of ITGB4 mRNA

PMID:12634122 PMID:12773770

NCBI chr10:101,206,657...101,243,012
Ensembl chr10:101,206,665...101,243,012

G

jumonji domain containing 6, arginine demethylase and lysine hydroxylase

multiple interactions

[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of JMJD6 mRNA

NCBI chr10:102,041,131...102,047,182
Ensembl chr10:102,041,120...102,047,182

G

Jupiter microtubule associated homolog 1

multiple interactions

[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of JPT1 mRNA

NCBI chr10:100,744,468...100,762,504
Ensembl chr10:100,686,797...100,784,513

G

JunB proto-oncogene, AP-1 transcription factor subunit

multiple interactions

Methylnitronitrosoguanidine promotes the reaction [[FOSL1 protein binds to JUNB protein] which binds to RRM2 promoter]; Methylnitronitrosoguanidine promotes the reaction [[FOSL1 protein binds to JUNB protein] which results in increased expression of RRM2 mRNA]

NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035

G

potassium channel tetramerization domain containing 12

increases expression

Methylnitronitrosoguanidine results in increased expression of KCTD12 mRNA

NCBI chr15:79,800,078...79,806,017
Ensembl chr15:79,801,191...79,806,282

G

lysine demethylase 8

multiple interactions

Methylnitronitrosoguanidine inhibits the reaction [TP53 protein binds to KDM8 protein]

NCBI chr 1:180,013,969...180,028,829
Ensembl chr 1:180,020,656...180,028,841

G

KIT proto-oncogene receptor tyrosine kinase

increases expression

Methylnitronitrosoguanidine results in increased expression of KIT mRNA

NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652

G

KIT ligand

decreases expression

Methylnitronitrosoguanidine results in decreased expression of KITLG mRNA

NCBI chr 7:34,896,075...34,977,215
Ensembl chr 7:34,896,053...34,977,214

G

KLF transcription factor 10

decreases expression

Methylnitronitrosoguanidine results in decreased expression of KLF10 mRNA

NCBI chr 7:69,467,658...69,473,726
Ensembl chr 7:69,465,619...69,473,994

G

KLF transcription factor 7

multiple interactions
increases expression

KLF7 protein inhibits the reaction [MIR520F inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CDH1 mRNA]]; KLF7 protein inhibits the reaction [MIR520F inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CDH1 protein]]; KLF7 protein inhibits the reaction [MIR520F inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of CDH2 mRNA]]; KLF7 protein inhibits the reaction [MIR520F inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of CDH2 protein]]; KLF7 protein inhibits the reaction [MIR520F inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of NFKB1 protein]]; KLF7 protein inhibits the reaction [MIR520F inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of RELA protein]]; KLF7 protein inhibits the reaction [MIR520F inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of SNAI1 protein]]; KLF7 protein inhibits the reaction [MIR520F inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of TWIST1 protein]]; KLF7 protein inhibits the reaction [MIR520F inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of VIM mRNA]]; KLF7 protein inhibits the reaction [MIR520F inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of VIM protein]]; MIR520F inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of KLF7 mRNA]; MIR520F inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of KLF7 protein]
Methylnitronitrosoguanidine results in increased expression of KLF7 mRNA; Methylnitronitrosoguanidine results in increased expression of KLF7 protein
KLF7 protein promotes the reaction [Methylnitronitrosoguanidine results in decreased expression of CDH1 mRNA]; KLF7 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of CDH2 mRNA]; KLF7 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of NFKB1 protein]; KLF7 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of SNAI1 protein]; KLF7 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of TWIST1 protein]; KLF7 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of VIM mRNA]; KLF7 protein promotes the reaction [Methylnitronitrosoguanidine results in increased phosphorylation of RELA protein]; KLF7 protein promotes the reaction [Methylnitronitrosoguanidine results in increased secretion of IL1B protein]; KLF7 protein promotes the reaction [Methylnitronitrosoguanidine results in increased secretion of IL6 protein]

NCBI chr 9:65,433,683...65,526,372
Ensembl chr 9:65,437,167...65,526,261

G

KRAS proto-oncogene, GTPase

multiple interactions
increases expression

geraniol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of KRAS mRNA]

NCBI chr 4:178,185,418...178,218,484

G

keratin 17

decreases expression

Methylnitronitrosoguanidine results in decreased expression of KRT17 mRNA

NCBI chr10:85,178,673...85,183,392
Ensembl chr10:85,178,675...85,183,392

G

lactate dehydrogenase A

multiple interactions
increases expression

corilagin inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of LDHA mRNA]

NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472

G

galectin 3

multiple interactions

[Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of LGALS3 mRNA

NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025

G

galectin 8

increases expression

Methylnitronitrosoguanidine results in increased expression of LGALS8 mRNA

NCBI chr17:58,024,652...58,052,764
Ensembl chr17:58,028,105...58,052,764

G

DNA ligase 1

decreases expression

Methylnitronitrosoguanidine results in decreased expression of LIG1 mRNA

NCBI chr 1:74,165,688...74,204,400
Ensembl chr 1:74,165,842...74,204,413

G

lipase A, lysosomal acid type

increases expression

Methylnitronitrosoguanidine results in increased expression of LIP1 mRNA

NCBI chr 1:232,024,351...232,057,735
Ensembl chr 1:232,024,356...232,057,633

G

lysyl oxidase

multiple interactions

[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of LOX mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of LOX mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of LOX mRNA

NCBI chr18:45,964,544...45,977,431
Ensembl chr18:45,967,343...46,041,477

G

lipoprotein lipase

multiple interactions

[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of LPL mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of LPL mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of LPL mRNA

NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249

G

mitogen activated protein kinase kinase 1

increases expression
multiple interactions

Methylnitronitrosoguanidine results in increased expression of MAP2K1 mRNA
geraniol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of MAP2K1 mRNA]

NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147

G

mitogen activated protein kinase kinase kinase 12

multiple interactions

[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of MAP3K12 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of MAP3K12 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of MAP3K12 mRNA

NCBI chr 7:133,630,267...133,648,464
Ensembl chr 7:133,630,835...133,640,789

G

mitogen activated protein kinase 1

multiple interactions
decreases phosphorylation

N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Methylnitronitrosoguanidine results in decreased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Methylnitronitrosoguanidine results in decreased phosphorylation of MAPK1 protein]]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 14

increases phosphorylation

Methylnitronitrosoguanidine results in increased phosphorylation of MAPK14 protein

NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589

G

mitogen activated protein kinase 3

multiple interactions
decreases phosphorylation

N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Methylnitronitrosoguanidine results in decreased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Methylnitronitrosoguanidine results in decreased phosphorylation of MAPK3 protein]]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 4

increases expression

Methylnitronitrosoguanidine results in increased expression of MAPK4 mRNA

NCBI chr18:67,512,805...67,661,271
Ensembl chr18:67,512,807...67,661,842

G

mitogen-activated protein kinase 8

increases phosphorylation

Methylnitronitrosoguanidine results in increased phosphorylation of MAPK8 protein

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

mitogen-activated protein kinase 9

increases expression

Methylnitronitrosoguanidine results in increased expression of MAPK9 mRNA

NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178

G

myristoylated alanine rich protein kinase C substrate

multiple interactions

[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of MARCKS mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of MARCKS mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of MARCKS mRNA

NCBI chr20:40,685,315...40,691,012
Ensembl chr20:40,685,315...40,691,012

G

MYC associated factor X

increases expression

Methylnitronitrosoguanidine results in increased expression of MAX mRNA

NCBI chr 6:95,636,859...95,662,204
Ensembl chr 6:95,636,858...95,662,137

G

melanoma cell adhesion molecule

increases expression

Methylnitronitrosoguanidine results in increased expression of MCAM mRNA

PMID:12634122 PMID:12773770

NCBI chr 8:44,479,391...44,487,575
Ensembl chr 8:44,479,376...44,487,571

G

minichromosome maintenance complex component 2

decreases expression
multiple interactions

Methylnitronitrosoguanidine results in decreased expression of MCM2 mRNA
[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of MCM2 mRNA

PMID:12634122 PMID:19840844

NCBI chr 4:121,346,434...121,360,962
Ensembl chr 4:121,346,434...121,360,847

G

minichromosome maintenance complex component 4

decreases expression

Methylnitronitrosoguanidine results in decreased expression of MCM4 mRNA

NCBI chr11:85,258,443...85,272,144
Ensembl chr11:85,258,443...85,272,144

G

minichromosome maintenance complex component 6

multiple interactions

[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of MCM6 mRNA

NCBI chr13:39,826,745...39,851,937
Ensembl chr13:39,826,763...39,851,960

G

MDM2 proto-oncogene

increases expression
multiple interactions

Methylnitronitrosoguanidine results in increased expression of MDM2 mRNA
Cadmium Chloride promotes the reaction [Methylnitronitrosoguanidine results in increased expression of MDM2 protein]

PMID:12135628 PMID:12634122

NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915

G

MDS1 and EVI1 complex locus

increases expression

Methylnitronitrosoguanidine results in increased expression of MECOM mRNA

NCBI chr 2:112,909,353...113,464,583
Ensembl chr 2:112,909,321...113,464,590

G

MET proto-oncogene, receptor tyrosine kinase

increases expression

Methylnitronitrosoguanidine results in increased expression of MET mRNA

NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876

G

O-6-methylguanine-DNA methyltransferase

decreases response to substance

MGMT protein results in decreased susceptibility to Methylnitronitrosoguanidine

PMID:1727384 PMID:15010311 PMID:16043385

NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756

G

microsomal glutathione S-transferase 2

decreases expression

Methylnitronitrosoguanidine results in decreased expression of MGST2 mRNA

NCBI chr 2:135,679,524...135,715,828
Ensembl chr 2:135,693,557...135,715,828

G

microsomal glutathione S-transferase 3

multiple interactions

[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of MGST3 mRNA

NCBI chr13:79,526,541...79,547,479
Ensembl chr13:79,526,541...79,547,411

G

microRNA 21

increases expression

Methylnitronitrosoguanidine results in increased expression of MIR21 mRNA

NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348

G

mutL homolog 1

decreases expression

Methylnitronitrosoguanidine results in decreased expression of MLH1 protein

NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617

G

matrix metallopeptidase 2

multiple interactions
increases expression

Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of and results in increased activity of MMP2 protein]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of MMP2 mRNA]; Methylnitronitrosoguanidine results in increased expression of and results in increased activity of MMP2 protein
[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of MMP2 mRNA

PMID:19840844 PMID:20434464

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

multiple interactions
increases expression

Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of and results in increased activity of MMP9 protein]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of MMP9 mRNA]; Methylnitronitrosoguanidine results in increased expression of and results in increased activity of MMP9 protein

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

N-methylpurine-DNA glycosylase

increases response to substance

MPG protein results in increased susceptibility to Methylnitronitrosoguanidine

NCBI chr10:15,396,246...15,402,528
Ensembl chr10:15,395,782...15,402,520

G

MAGUK p55 scaffold protein 1

multiple interactions

[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of MPP1 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of MPP1 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of MPP1 mRNA

G

mutS homolog 2

increases expression

Methylnitronitrosoguanidine results in increased expression of MSH2 mRNA

NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938

G

macrophage stimulating 1

increases expression

Methylnitronitrosoguanidine results in increased expression of MST1 mRNA

NCBI chr 8:108,767,886...108,773,425
Ensembl chr 8:108,768,839...108,773,416

G

metallothionein 1

multiple interactions

[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of MT1 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of MT1 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of MT1 mRNA

NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049
Ensembl chr X:10,826,032...10,827,049

G

methylenetetrahydrofolate reductase

increases methylation

Methylnitronitrosoguanidine results in increased methylation of MTHFR promoter

NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797

G

mutY DNA glycosylase

multiple interactions

MUTYH protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of PARP1 protein]

NCBI chr 5:130,274,034...130,286,149
Ensembl chr 5:130,274,122...130,286,146

G

MX dynamin like GTPase 2

increases expression

Methylnitronitrosoguanidine results in increased expression of MX2 mRNA

NCBI chr11:36,905,698...36,936,308
Ensembl chr11:36,906,111...36,930,342

G

MYB proto-oncogene like 1

increases expression

Methylnitronitrosoguanidine results in increased expression of MYBL1 mRNA

NCBI chr 5:9,582,905...9,618,179
Ensembl chr 5:9,582,934...9,618,183

G

MYC proto-oncogene, bHLH transcription factor

increases expression
multiple interactions

Methylnitronitrosoguanidine results in increased expression of MYC protein
Cadmium Chloride promotes the reaction [Methylnitronitrosoguanidine results in increased expression of MYC protein]

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

myosin light chain 2

increases expression

Methylnitronitrosoguanidine results in increased expression of MYL2 mRNA

NCBI chr12:34,454,223...34,468,554
Ensembl chr12:34,454,218...34,468,983

G

myosin light chain 9

increases expression

Methylnitronitrosoguanidine results in increased expression of MYL9 mRNA

NCBI chr 3:145,281,943...145,288,333
Ensembl chr 3:145,281,937...145,288,333

G

myosin light chain kinase

decreases expression

Methylnitronitrosoguanidine results in decreased expression of MYLK mRNA

NCBI chr11:65,783,008...66,030,239
Ensembl chr11:65,783,008...66,030,261

G

NBL1, DAN family BMP antagonist

decreases expression

Methylnitronitrosoguanidine results in decreased expression of NBL1 mRNA

NCBI chr 5:151,318,752...151,329,948
Ensembl chr 5:151,318,754...151,338,719

G

nuclear factor kappa B subunit 1

multiple interactions
increases expression

Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of NFKB1 mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of NFKB1 protein]
KLF7 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of NFKB1 protein]
KLF7 protein inhibits the reaction [MIR520F inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of NFKB1 protein]]; MIR520F inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of NFKB1 protein]
Methylnitronitrosoguanidine results in increased expression of NFKB1 mRNA; Methylnitronitrosoguanidine results in increased expression of NFKB1 protein

PMID:19851710 PMID:38184286

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

NFKB inhibitor alpha

multiple interactions
increases expression
decreases expression

Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of NFKBIA mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of NFKBIA protein]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of NFKBIA protein modified form]
Methylnitronitrosoguanidine results in increased phosphorylation of and results in increased degradation of NFKBIA protein
Methylnitronitrosoguanidine results in decreased expression of NFKBIA mRNA; Methylnitronitrosoguanidine results in decreased expression of NFKBIA protein

PMID:19851710 PMID:22001597

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

nuclear transcription factor Y subunit alpha

multiple interactions

Methylnitronitrosoguanidine promotes the reaction [NFYA protein binds to RRM2 promoter]; Methylnitronitrosoguanidine promotes the reaction [NFYA protein results in increased expression of RRM2 mRNA]

NCBI chr 9:12,587,437...12,613,911
Ensembl chr 9:12,586,259...12,613,898

G

nuclear transcription factor Y subunit beta

multiple interactions

Methylnitronitrosoguanidine promotes the reaction [NFYB protein binds to RRM2 promoter]; Methylnitronitrosoguanidine promotes the reaction [NFYB protein results in increased expression of RRM2 mRNA]; NFYB protein promotes the reaction [Methylnitronitrosoguanidine promotes the reaction [E2F3 protein binds to RRM2 promoter]]; NFYB protein promotes the reaction [Methylnitronitrosoguanidine promotes the reaction [E2F3 protein results in increased expression of RRM2 mRNA]]; NFYB protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2 mRNA]; NFYB protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2 protein]

NCBI chr 7:20,964,988...20,980,569
Ensembl chr 7:20,964,993...20,980,565

G

nuclear transcription factor Y subunit gamma

multiple interactions

Methylnitronitrosoguanidine promotes the reaction [NFYC protein binds to RRM2 promoter]; Methylnitronitrosoguanidine promotes the reaction [NFYC protein results in increased expression of RRM2 mRNA]

NCBI chr 5:134,336,802...134,405,372
Ensembl chr 5:134,336,808...134,405,377

G

nicotinamide N-methyltransferase

increases activity

Methylnitronitrosoguanidine results in increased activity of NNMT protein

NCBI chr 8:48,928,663...48,947,734
Ensembl chr 8:48,933,598...4