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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:flufenamic acid
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Accession:CHEBI:42638 term browser browse the term
Definition:An aromatic amino acid consisting of anthranilic acid carrying an N-(trifluoromethyl)phenyl substituent. An analgesic and anti-inflammatory, it is used in rheumatic disorders.
Synonyms:related_synonym: 2-[3-(trifluoromethyl)anilino]benzoic acid;   2-[[3-(TRIFLUOROMETHYL)PHENYL]AMINO] BENZOIC ACID;   3'-trifluoromethyldiphenylamine-2-carboxylic acid;   Achless;   FFA;   Flufenaminsaeure;   Formula=C14H10F3NO2;   InChI=1S/C14H10F3NO2/c15-14(16,17)9-4-3-5-10(8-9)18-12-7-2-1-6-11(12)13(19)20/h1-8,18H,(H,19,20);   InChIKey=LPEPZBJOKDYZAD-UHFFFAOYSA-N;   N-(3-trifluoromethylphenyl)anthranilic acid;   N-(alpha,alpha,alpha-trifluoro-m-tolyl)anthranilic acid;   SMILES=OC(=O)c1ccccc1Nc1cccc(c1)C(F)(F)F;   acide flufenamique;   acido flufenamico;   acidum flufenamicum;   fluphenamic acid
 alt_id: CHEBI:31619;   CHEBI:42631
 xref: Beilstein:1996069;   CAS:530-78-9;   DrugBank:DB02266;   Drug_Central:1193;   Gmelin:1327188;   KEGG:C13038;   KEGG:D01581;   LINCS:LSM-2973
 xref_mesh: MESH:D005439
 xref: PDBeChem:FLF;   PMID:11093589;   PMID:15275834;   PMID:18436631;   PMID:20589945;   PMID:28166217;   Reaxys:1996069;   Wikipedia:Flufenamic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:520819


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flufenamic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam17 ADAM metallopeptidase domain 17 increases response to substance ISO ADAM17 results in increased susceptibility to Flufenamic Acid CTD PMID:12147693 NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639 		JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 decreases activity
multiple interactions		 ISO Flufenamic Acid results in decreased activity of AKR1C1 protein
Flufenamic Acid inhibits the reaction [AKR1C1 protein affects the susceptibility to Oxaliplatin]; Flufenamic Acid inhibits the reaction [AKR1C1 protein results in increased metabolism of Dihydrotestosterone]		 CTD PMID:8573067 PMID:12604236 PMID:14672942 PMID:23933386 NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326 		JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 multiple interactions
decreases activity		 ISO Flufenamic Acid inhibits the reaction [AKR1C2 protein results in increased metabolism of Dihydrotestosterone]
Flufenamic Acid results in decreased activity of AKR1C2 protein		 CTD PMID:8573067 PMID:12604236 PMID:14672942 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 affects binding
decreases activity
multiple interactions		 ISO Flufenamic Acid binds to AKR1C3 protein
Flufenamic Acid results in decreased activity of AKR1C3 protein
Flufenamic Acid inhibits the reaction [AKR1C3 protein affects the susceptibility to oxaliplatin]; Flufenamic Acid inhibits the reaction [AKR1C3 protein results in increased metabolism of Dihydrotestosterone]		 CTD PMID:12604236 PMID:14672942 PMID:14996743 PMID:23933386 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G Ar androgen receptor multiple interactions
decreases expression		 ISO Flufenamic Acid analog binds to and results in decreased activity of AR protein; Flufenamic Acid binds to and results in decreased activity of AR protein
Flufenamic Acid results in decreased expression of AR mRNA; Flufenamic Acid results in decreased expression of AR protein		 CTD PMID:10537180 PMID:19645433 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Asic5 acid sensing ion channel subunit family member 5 multiple interactions ISO Flufenamic Acid binds to and results in increased activity of ASIC5 protein CTD PMID:21828194 NCBI chr 2:167,307,984...167,336,812
Ensembl chr 2:167,307,984...167,336,812 		JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions ISO Flufenamic Acid inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAD protein] CTD PMID:27957685 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions ISO Flufenamic Acid inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAK1 protein] CTD PMID:27957685 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Best1 bestrophin 1 decreases activity ISO Flufenamic Acid results in decreased activity of BEST1 protein CTD PMID:19828819 NCBI chr 1:206,629,340...206,646,085
Ensembl chr 1:206,629,500...206,646,063 		JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO Flufenamic Acid inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BID protein] CTD PMID:27957685 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO Flufenamic Acid inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CASP3 protein modified form] CTD PMID:27957685 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casr calcium-sensing receptor multiple interactions ISO Flufenamic Acid promotes the reaction [CASR protein results in increased uptake of Calcium] CTD PMID:21562303 NCBI chr11:64,235,251...64,304,811
Ensembl chr11:64,235,251...64,304,811 		JBrowse link
G Cftr CF transmembrane conductance regulator decreases activity ISO Flufenamic Acid results in decreased activity of CFTR protein CTD PMID:15277574 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756 		JBrowse link
G Cga glycoprotein hormones, alpha polypeptide multiple interactions EXP [Flufenamic Acid results in decreased abundance of Cyclic AMP] which results in decreased expression of CGA mRNA CTD PMID:8404651 NCBI chr 5:49,486,915...49,499,192
Ensembl chr 5:49,487,068...49,499,191 		JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 multiple interactions ISO Flufenamic Acid inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium] CTD PMID:18316702 NCBI chr 1:205,567,226...205,583,001
Ensembl chr 1:205,567,220...205,582,356 		JBrowse link
G Dhrs11 dehydrogenase/reductase 11 decreases activity ISO Flufenamic Acid results in decreased activity of DHRS11 protein CTD PMID:30926317 NCBI chr10:69,698,214...69,708,294
Ensembl chr10:69,698,214...69,708,295 		JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions EXP [Flufenamic Acid results in decreased abundance of Cyclic AMP] which results in decreased expression of FSHB mRNA CTD PMID:8404651 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370 		JBrowse link
G Grm1 glutamate metabotropic receptor 1 multiple interactions EXP Flufenamic Acid inhibits the reaction [3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein]; Flufenamic Acid inhibits the reaction [[3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein] which results in increased abundance of Calcium] CTD PMID:14622174 NCBI chr 1:5,058,285...5,453,170
Ensembl chr 1:5,058,292...5,453,170 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Flufenamic Acid inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO Flufenamic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A protein] CTD PMID:10866999 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions		 EXP
ISO		 Flufenamic Acid results in increased expression of IL6 mRNA
Flufenamic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]		 CTD PMID:15135310 PMID:24849676 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions ISO E 4031 inhibits the reaction [Flufenamic Acid promotes the reaction [KCNH2 protein results in increased transport of Potassium]]; Flufenamic Acid promotes the reaction [KCNH2 protein results in increased transport of Potassium] CTD PMID:12359267 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Kcnk10 potassium two pore domain channel subfamily K member 10 multiple interactions ISO Flufenamic Acid promotes the reaction [KCNK10 protein results in increased transport of Potassium] CTD PMID:16075240 NCBI chr 6:117,690,052...117,826,120
Ensembl chr 6:117,694,222...117,825,695 		JBrowse link
G Kcnk2 potassium two pore domain channel subfamily K member 2 multiple interactions ISO Flufenamic Acid promotes the reaction [KCNK2 protein results in increased transport of Potassium] CTD PMID:16075240 NCBI chr13:100,766,101...100,963,435
Ensembl chr13:100,766,113...100,963,435 		JBrowse link
G Kcnk4 potassium two pore domain channel subfamily K member 4 multiple interactions ISO Flufenamic Acid promotes the reaction [KCNK4 protein results in increased transport of Potassium] CTD PMID:16075240 NCBI chr 1:204,117,941...204,129,494
Ensembl chr 1:204,114,572...204,125,925 		JBrowse link
G Kiss1 KiSS-1 metastasis-suppressor multiple interactions ISO Flufenamic Acid inhibits the reaction [[KISS1 protein results in increased activity of KISS1R protein] which results in increased abundance of Calcium] CTD PMID:18948403 NCBI chr13:44,775,106...44,780,707
Ensembl chr13:44,774,823...44,780,612 		JBrowse link
G Kiss1r KISS1 receptor multiple interactions ISO Flufenamic Acid inhibits the reaction [[KISS1 protein results in increased activity of KISS1R protein] which results in increased abundance of Calcium] CTD PMID:18948403 NCBI chr 7:9,785,135...9,790,283
Ensembl chr 7:9,785,135...9,788,793 		JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions
increases expression		 ISO Flufenamic Acid inhibits the reaction [Cyclosporine inhibits the reaction [[Cholesterol, LDL binds to LDLR protein] which results in increased degradation of Cholesterol, LDL]]; Flufenamic Acid promotes the reaction [[Cholesterol, LDL binds to LDLR protein] which results in increased degradation of Cholesterol, LDL]; Flufenamic Acid promotes the reaction [Cholesterol, LDL binds to LDLR protein]
Flufenamic Acid results in increased expression of LDLR mRNA; Flufenamic Acid results in increased expression of LDLR protein		 CTD PMID:10395027 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580 		JBrowse link
G Lep leptin multiple interactions ISO Flufenamic Acid inhibits the reaction [LEP protein results in increased transport of Calcium] CTD PMID:20107083 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP [Flufenamic Acid results in decreased abundance of Cyclic AMP] which results in decreased expression of LHB mRNA CTD PMID:8404651 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Nkx3-1 NK3 homeobox 1 multiple interactions ISO Flufenamic Acid inhibits the reaction [mibolerone results in increased expression of NKX3-1 mRNA] CTD PMID:10537180 NCBI chr15:44,473,851...44,476,443
Ensembl chr15:44,473,851...44,476,441 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression		 ISO
EXP		 Flufenamic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
Flufenamic Acid results in increased expression of NOS2 mRNA		 CTD PMID:10866999 PMID:15135310 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Panx1 Pannexin 1 decreases activity ISO Flufenamic Acid results in decreased activity of PANX1 protein CTD PMID:19023039 NCBI chr 8:11,851,176...11,889,774
Ensembl chr 8:11,850,730...11,889,774 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO Flufenamic Acid binds to and results in increased activity of PPARA protein CTD PMID:9013583 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases activity		 ISO [Flufenamic Acid results in increased activity of PPARG protein] which results in increased expression of PTGS2 protein; Flufenamic Acid binds to and results in increased activity of PPARG protein CTD PMID:9013583 PMID:10866999 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression		 ISO [Flufenamic Acid results in increased activity of PPARG protein] which results in increased expression of PTGS2 protein; Flufenamic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; Flufenamic Acid inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]
Flufenamic Acid results in increased expression of PTGS2 mRNA; Flufenamic Acid results in increased expression of PTGS2 protein		 CTD PMID:10866999 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Sell selectin L decreases expression ISO Flufenamic Acid results in decreased expression of SELL protein CTD PMID:12147693 NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456 		JBrowse link
G Slc6a11 solute carrier family 6 member 11 multiple interactions ISO Flufenamic Acid inhibits the reaction [SLC6A11 protein results in increased uptake of gamma-Aminobutyric Acid] CTD PMID:15981712 NCBI chr 4:147,297,972...147,413,319
Ensembl chr 4:147,297,969...147,413,443 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 ISO
EXP		 Flufenamic Acid inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]
Flufenamic Acid results in increased expression of TNF mRNA		 CTD PMID:10866999 PMID:15135310 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 multiple interactions
increases activity		 ISO
EXP		 [Flufenamic Acid results in increased activity of TRPC6 protein] which results in increased uptake of Calcium
Flufenamic Acid inhibits the reaction [1-oleoyl-2-acetoyl-sn-glycerol promotes the reaction [TRPC6 protein results in increased uptake of Calcium]]; Flufenamic Acid inhibits the reaction [1-oleoyl-2-acetoyl-sn-glycerol promotes the reaction [TRPC6 protein results in increased uptake of Manganese]]		 CTD PMID:11535132 PMID:14551041 PMID:21562303 NCBI chr 8:5,759,387...5,864,000
Ensembl chr 8:5,758,935...5,828,092 		JBrowse link
G Trpm2 transient receptor potential cation channel, subfamily M, member 2 multiple interactions EXP Flufenamic Acid inhibits the reaction [Adenosine Diphosphate Ribose promotes the reaction [TRPM2 protein results in increased transport of Calcium]] CTD PMID:21900507 NCBI chr20:10,703,568...10,753,189
Ensembl chr20:10,707,014...10,753,181 		JBrowse link
G Trpm4 transient receptor potential cation channel, subfamily M, member 4 decreases activity ISO
EXP		 Flufenamic Acid results in decreased activity of TRPM4 protein CTD PMID:16966582 PMID:17188667 NCBI chr 1:95,781,805...95,812,095
Ensembl chr 1:95,782,000...95,812,532 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      application 19695
        solvent 17235
          (trifluoromethyl)benzene 440
            flufenamic acid 42
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    main group molecular entity 19817
                      s-block molecular entity 19653
                        hydrogen molecular entity 19634
                          hydrides 19144
                            organic hydride 18691
                              organic fundamental parent 18691
                                hydrocarbon 18442
                                  halohydrocarbon 15851
                                    haloalkane 12900
                                      fluoroalkane 9224
                                        fluoromethanes 6773
                                          tetrafluoromethane 6773
                                            trifluoromethyl group 6773
                                              (trifluoromethyl)benzenes 6773
                                                (trifluoromethyl)benzene 440
                                                  flufenamic acid 42
paths to the root