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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:4-hydroxyphenyl retinamide
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Accession:CHEBI:42588 term browser browse the term
Definition:A retinoid obtained by formal condensation of the carboxy group of all-trans retinoic acid and the anilino group of 4-hydroxyaniline. Synthetic retinoid agonist. Antiproliferative, antioxidant and anticancer agent with a long half-life in vivo. Apoptotic effects appear to be mediated by a mechanism distinct from that of 'classical' retinoids.
Synonyms:exact_synonym: 15-[(4-hydroxyphenyl)amino]retinal
 related_synonym: 4-HPR;   4-hydroxy(phenyl)retinamide;   Formula=C26H33NO2;   InChI=1S/C26H33NO2/c1-19(11-16-24-21(3)10-7-17-26(24,4)5)8-6-9-20(2)18-25(29)27-22-12-14-23(28)15-13-22/h6,8-9,11-16,18,28H,7,10,17H2,1-5H3,(H,27,29)/b9-6+,16-11+,19-8+,20-18+;   InChIKey=AKJHMTWEGVYYSE-FXILSDISSA-N;   N-(4-Hydroxyphenyl)retinamide;   N-(4-hydroxyphenyl)all-trans retinamide;   SMILES=CC(\\C=C\\C1=C(C)CCCC1(C)C)=C/C=C/C(C)=C/C(=O)Nc1ccc(O)cc1;   all-trans-4'-Hydroxyretinanilide;   fenretinida;   fenretinide;   fenretinidum
 xref: CAS:65646-68-6;   DrugBank:DB05076;   KEGG:D04162
 xref_mesh: MESH:D017313
 xref: PDBeChem:FEN;   PMID:20878269;   PMID:20978709;   PMID:21241664;   PMID:21319187;   PMID:21674264;   PMID:21964808;   PMID:22094120;   PMID:22162577;   PMID:22183330;   PMID:22221098;   PMID:22280430;   PMID:22323082;   PMID:22350416;   PMID:22382323;   PMID:22387538;   Reaxys:5769490



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      CHEBI ontology 19917
        role 19887
          chemical role 19514
            antioxidant 16169
              4-hydroxyphenyl retinamide 3992
    Path 2
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      CHEBI ontology 19917
        subatomic particle 19915
          composite particle 19915
            hadron 19915
              baryon 19915
                nucleon 19915
                  atomic nucleus 19915
                    atom 19915
                      main group element atom 19855
                        p-block element atom 19855
                          carbon group element atom 19794
                            carbon atom 19790
                              organic molecular entity 19790
                                heteroorganic entity 19548
                                  organochalcogen compound 19307
                                    organooxygen compound 19223
                                      carbon oxoacid 18687
                                        carboxylic acid 18684
                                          carboacyl group 17720
                                            univalent carboacyl group 17720
                                              carbamoyl group 17571
                                                carboxamide 17571
                                                  monocarboxylic acid amide 15747
                                                    4-hydroxyphenyl retinamide 3992
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