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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:forskolin
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Accession:CHEBI:42471 term browser browse the term
Definition:A labdane diterpenoid isolated from the Indian Coleus plant.
Synonyms:exact_synonym: (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxododecahydro-1H-benzo[f]chromen-5-yl acetate
 related_synonym: 7beta-acetoxy-8,13-epoxy-1alpha,6beta,9alpha-trihydroxylabd-14-en-11-one;   Coleonol;   Coleonolk;   Formula=C22H34O7;   InChI=1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(26)17(28-12(2)23)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16-,17-,19-,20-,21+,22-/m0/s1;   InChIKey=OHCQJHSOBUTRHG-KGGHGJDLSA-N;   SMILES=[H][C@@]12[C@H](O)[C@H](OC(C)=O)[C@@]3(C)O[C@](C)(CC(=O)[C@]3(O)[C@@]1(C)[C@@H](O)CCC2(C)C)C=C;   colforsin;   colforsina;   colforsine;   colforsinum
 xref: CAS:66428-89-5;   CAS:66575-29-9;   DrugBank:DB02587;   KEGG:C09076;   KEGG:D03584;   KNApSAcK:C00003416;   PDBeChem:FOK;   PMID:11816015;   PMID:12676767;   PMID:12836714;   PMID:14691682;   PMID:15135319;   PMID:15380183;   PMID:1547891;   PMID:15525467;   PMID:16644480;   PMID:17570033;   PMID:19831022;   PMID:7755573;   PMID:7875530;   PMID:7898427;   PMID:7929167;   PMID:8489512;   PMID:8985363;   PMID:9478958;   PMID:9828101;   Patent:DE2557784;   Patent:US4088659;   Patent:US4476140;   Reaxys:4300863;   Wikipedia:Forskolin


show annotations for term's descendants           Sort by:
forskolin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc6a4 solute carrier family 6 member 4 increases activity ISO forskolin increases activity of SLC6A4 protein in placental choriocarcinoma cells RGD PMID:8408014 RGD:36947876 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384 		JBrowse link
1,9-dideoxyforskolin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity EXP 1,9-dideoxyforskolin results in decreased activity of ABCB1A protein CTD PMID:12202523 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B decreases activity EXP 1,9-dideoxyforskolin results in decreased activity of ABCB1B protein CTD PMID:12202523 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199 		JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity EXP 1,9-dideoxyforskolin results in decreased activity of ABCB4 protein CTD PMID:12202523 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19867
    role 19837
      biological role 19835
        antimicrobial agent 18251
          antiviral agent 11347
            anti-HIV agent 2776
              forskolin 4
                1,9-dideoxyforskolin 3
                colforsin daropate 0
                methylpiperazinoforskolin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19867
    subatomic particle 19865
      composite particle 19865
        hadron 19865
          baryon 19865
            nucleon 19865
              atomic nucleus 19865
                atom 19865
                  main group element atom 19803
                    p-block element atom 19803
                      carbon group element atom 19744
                        carbon atom 19740
                          organic molecular entity 19740
                            heteroorganic entity 19512
                              organochalcogen compound 19273
                                organooxygen compound 19189
                                  carbon oxoacid 18660
                                    carboxylic acid 18657
                                      monocarboxylic acid 18008
                                        acetic acid 11087
                                          acetate ester 4057
                                            forskolin 4
                                              1,9-dideoxyforskolin 3
                                              colforsin daropate 0
                                              methylpiperazinoforskolin 0
paths to the root