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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:equilin
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Accession:CHEBI:42309 term browser browse the term
Definition:A 17-oxo steroid that has formula C18H20O2.
Synonyms:related_synonym: 1,3,5,7-Estratetraen-3-ol-17-one;   3-hydroxyestra-1,3,5(10),7-tetraen-17-one;   7-Dehydroestrone;   Dihydroequilenin
 alt_id: CHEBI:34740;   CHEBI:42304
 xref: Beilstein:2624302;   CAS:474-86-2;   DrugBank:DB02187
 xref_mesh: MESH:D004857
 xref: kegg.compound:C14392;   kegg.drug:D04041;   lincs.smallmolecule:LSM-2063;   lipidmaps:LMST02010026;   pdb-ccd:EQI
 chemrof_formula: C18H20O2
 chemrof_inchi: InChI=1S/C18H20O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3-5,10,14,16,19H,2,6-9H2,1H3/t14-,16+,18+/m1/s1
 chemrof_inchikey: WKRLQDKEXYKHJB-HFTRVMKXSA-N
 chemrof_smiles: [H][C@]12CC[C@]3(C)C(=O)CC[C@@]3([H])C1=CCc1cc(O)ccc12
 cyclic_relationship: has_parent_hybride CHEBI:23966



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equilin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO Equilin inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein] CTD PMID:29782964 NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169
JBrowse link
G Ar androgen receptor affects localization
multiple interactions
ISO Equilin affects the localization of AR protein
Equilin binds to and results in increased activity of AR protein; Equilin inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]
CTD PMID:28478275 PMID:33049310 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:67,135,317...67,304,467
JBrowse link
G Esr1 estrogen receptor 1 increases activity
multiple interactions
affects binding
EXP
ISO
Equilin results in increased activity of ESR1 protein
Equilin binds to and results in increased activity of ESR1 protein; Fulvestrant inhibits the reaction [Equilin results in increased activity of ESR1 protein]
Equilin binds to ESR1 protein
CTD PMID:11750080 PMID:12504345 PMID:21138273 PMID:22562034 PMID:33049310 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO Equilin binds to and results in increased activity of ESR2 protein CTD PMID:33049310 NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709
JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions ISO Equilin inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein] CTD PMID:29782964 NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:93,488,271...93,492,972
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Equilin inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705
JBrowse link
G Ins2 insulin 2 multiple interactions ISO Equilin inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein]; Equilin inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein] CTD PMID:29782964 NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:207,272,742...207,273,805
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Equilin binds to and results in decreased activity of NR1I2 protein
Equilin binds to and results in increased activity of NR1I2 protein
CTD PMID:33049310 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO Equilin binds to and results in decreased activity of PPARG protein CTD PMID:33049310 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104
JBrowse link
G Rxra retinoid X receptor alpha affects binding ISO Equilin binds to RXRA protein CTD PMID:31566444 NCBI chr 3:31,387,892...31,474,415
Ensembl chr 3:31,388,223...31,474,417
JBrowse link
G Tff1 trefoil factor 1 increases expression
multiple interactions
ISO Equilin results in increased expression of TFF1 mRNA
fulvestrant inhibits the reaction [Equilin results in increased expression of TFF1 mRNA]
CTD PMID:22562034 NCBI chr20:9,237,095...9,240,956
Ensembl chr20:9,237,095...9,240,956
JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO Equilin binds to and results in increased activity of THRA protein CTD PMID:33049310 NCBI chr10:84,198,141...84,225,659
Ensembl chr10:84,197,011...84,225,657
JBrowse link
G Utrn utrophin increases expression ISO Equilin results in increased expression of UTRN mRNA CTD PMID:22028826 NCBI chr 1:8,541,061...9,044,487
Ensembl chr 1:8,542,798...9,044,487
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    chemical entity 20872
      molecular entity 20871
        polyatomic entity 20745
          heteroatomic molecular entity 20606
            hydroxides 19922
              organic hydroxy compound 19685
                hydroxy steroid 14970
                  3-hydroxy steroid 13526
                    equilin 13
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      carbon group element atom 20712
                        carbon atom 20706
                          organic molecular entity 20706
                            heteroorganic entity 20201
                              organochalcogen compound 19822
                                organooxygen compound 19713
                                  carbonyl compound 18827
                                    ketone 17484
                                      oxo steroid 9896
                                        17-oxo steroid 280
                                          equilin 13
paths to the root