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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:digoxigenin
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Accession:CHEBI:42098 term browser browse the term
Definition:A hydroxy steroid that consists of 5beta-cardanolide having a double bond at the 20(22)-position as well as hydroxy groups at the 3beta-, 12beta- and 14beta-positions. It has been isolated from the plant species of the genus Digitalis.
Synonyms:exact_synonym: 3beta,12beta,14-trihydroxy-5beta-card-20(22)-enolide
 related_synonym: Formula=C23H34O5;   InChI=1S/C23H34O5/c1-21-7-5-15(24)10-14(21)3-4-17-18(21)11-19(25)22(2)16(6-8-23(17,22)27)13-9-20(26)28-12-13/h9,14-19,24-25,27H,3-8,10-12H2,1-2H3/t14-,15+,16-,17-,18+,19-,21+,22+,23+/m1/s1;   InChIKey=SHIBSTMRCDJXLN-KCZCNTNESA-N;   SMILES=[H][C@]12CC[C@]3([H])[C@]([H])(C[C@@H](O)[C@]4(C)[C@]([H])(CC[C@]34O)C3=CC(=O)OC3)[C@@]1(C)CC[C@H](O)C2
 alt_id: CHEBI:38020;   CHEBI:42096
 xref: CAS:1672-46-4;   HMDB:HMDB0060731;   LIPID_MAPS_instance:LMST01120008
 xref_mesh: MESH:D004076
 xref: MetaCyc:CPD-22579;   PDBeChem:DOG;   PMID:10438974;   PMID:23344238;   PMID:23383657;   PMID:8080093;   PMID:9470094;   Wikipedia:Digoxigenin
 cyclic_relationship: is_conjugate_acid_of CHEBI:145797


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digoxigenin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases transport ISO ABCB1 protein results in increased transport of Digoxigenin CTD PMID:26708294 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Digoxigenin results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression ISO Digoxigenin results in decreased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:68,963,893...68,965,728
Ensembl chr10:68,950,289...68,965,722 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 multiple interactions
increases expression 		ISO Digoxigenin promotes the reaction [RORC protein binds to G6PC1 promoter]
Digoxigenin results in increased expression of G6PC1 mRNA 		CTD PMID:29981919 NCBI chr10:86,807,659...86,819,023
Ensembl chr10:86,757,899...86,818,033 		JBrowse link
G Il17a interleukin 17A multiple interactions ISO Digoxigenin results in increased expression of and results in increased secretion of IL17A protein CTD PMID:29981919 NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:30,640,844...30,644,331 		JBrowse link
G Il17f interleukin 17F multiple interactions ISO Digoxigenin results in increased expression of and results in increased secretion of IL17F protein CTD PMID:29981919 NCBI chr 9:30,686,532...30,697,918
Ensembl chr 9:30,686,538...30,697,918 		JBrowse link
G Il6r interleukin 6 receptor decreases expression ISO Digoxigenin results in decreased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 2:177,582,020...177,646,705
Ensembl chr 2:177,582,164...177,645,221 		JBrowse link
G Npas2 neuronal PAS domain protein 2 increases expression
multiple interactions 		ISO Digoxigenin results in increased expression of NPAS2 mRNA
Digoxigenin promotes the reaction [RORC protein binds to NPAS2 promoter] 		CTD PMID:29981919 NCBI chr 9:48,959,225...49,138,036
Ensembl chr 9:48,959,148...49,138,037 		JBrowse link
G Rorc RAR-related orphan receptor C increases expression
multiple interactions 		ISO Digoxigenin results in increased expression of RORC mRNA
Digoxigenin promotes the reaction [RORC protein binds to G6PC1 promoter]; Digoxigenin promotes the reaction [RORC protein binds to NPAS2 promoter]; RORC protein promotes the reaction [Digoxigenin results in increased expression of RORC mRNA] 		CTD PMID:29981919 NCBI chr 2:184,698,779...184,723,942
Ensembl chr 2:184,698,818...184,724,566 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Digoxigenin results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20873
    role 20805
      biological role 20829
        hapten 3096
          digoxigenin 10
            20,22-dihydrodigoxigenin 0
            Dig-Cy5 0
            digoxigenin 3,12-diacetate 0
            digoxigenin monodigitoxoside 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20873
    subatomic particle 20871
      composite particle 20871
        hadron 20871
          baryon 20871
            nucleon 20871
              atomic nucleus 20871
                atom 20871
                  main group element atom 20794
                    p-block element atom 20794
                      carbon group element atom 20727
                        carbon atom 20722
                          organic molecular entity 20722
                            heteroorganic entity 20226
                              organochalcogen compound 19910
                                organooxygen compound 19813
                                  ester 17795
                                    carboxylic ester 17246
                                      lactone 13381
                                        steroid lactone 497
                                          cardanolide 52
                                            5beta-cardanolide 52
                                              digoxigenin 10
                                                20,22-dihydrodigoxigenin 0
                                                Dig-Cy5 0
                                                digoxigenin 3,12-diacetate 0
                                                digoxigenin monodigitoxoside 0
paths to the root