CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: digoxigenin
Accession: CHEBI:42098
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Definition: A hydroxy steroid that consists of 5beta-cardanolide having a double bond at the 20(22)-position as well as hydroxy groups at the 3beta-, 12beta- and 14beta-positions. It has been isolated from the plant species of the genus Digitalis.
Synonyms: exact_synonym: 3beta,12beta,14-trihydroxy-5beta-card-20(22)-enolide
related_synonym: Formula=C23H34O5; InChI=1S/C23H34O5/c1-21-7-5-15(24)10-14(21)3-4-17-18(21)11-19(25)22(2)16(6-8-23(17,22)27)13-9-20(26)28-12-13/h9,14-19,24-25,27H,3-8,10-12H2,1-2H3/t14-,15+,16-,17-,18+,19-,21+,22+,23+/m1/s1; InChIKey=SHIBSTMRCDJXLN-KCZCNTNESA-N; SMILES=[H][C@]12CC[C@]3([H])[C@]([H])(C[C@@H](O)[C@]4(C)[C@]([H])(CC[C@]34O)C3=CC(=O)OC3)[C@@]1(C)CC[C@H](O)C2
alt_id: CHEBI:38020; CHEBI:42096
xref: CAS:1672-46-4; HMDB:HMDB0060731; LIPID_MAPS_instance:LMST01120008
xref_mesh: MESH:D004076
xref: MetaCyc:CPD-22579; PDBeChem:DOG; PMID:10438974; PMID:23344238; PMID:23383657; PMID:8080093; PMID:9470094; Wikipedia:Digoxigenin
cyclic_relationship: is_conjugate_acid_of CHEBI:145797
G
Abcb1a
ATP binding cassette subfamily B member 1A
increases transport
ISO
ABCB1 protein results in increased transport of Digoxigenin
CTD
PMID:26708294
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Ccl2
C-C motif chemokine ligand 2
decreases expression
ISO
Digoxigenin results in decreased expression of CCL2 protein
CTD
PMID:20116850
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Ccl4
C-C motif chemokine ligand 4
decreases expression
ISO
Digoxigenin results in decreased expression of CCL4 protein
CTD
PMID:20116850
NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231
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G6pc1
glucose-6-phosphatase catalytic subunit 1
multiple interactions increases expression
ISO
Digoxigenin promotes the reaction [RORC protein binds to G6PC1 promoter] Digoxigenin results in increased expression of G6PC1 mRNA
CTD
PMID:29981919
NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804
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Il17a
interleukin 17A
multiple interactions
ISO
Digoxigenin results in increased expression of and results in increased secretion of IL17A protein
CTD
PMID:29981919
NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
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Il17f
interleukin 17F
multiple interactions
ISO
Digoxigenin results in increased expression of and results in increased secretion of IL17F protein
CTD
PMID:29981919
NCBI chr 9:23,190,094...23,201,482
Ensembl chr 9:23,190,100...23,201,482
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Il6r
interleukin 6 receptor
decreases expression
ISO
Digoxigenin results in decreased expression of IL6R protein modified form
CTD
PMID:20116850
NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536
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Npas2
neuronal PAS domain protein 2
increases expression multiple interactions
ISO
Digoxigenin results in increased expression of NPAS2 mRNA Digoxigenin promotes the reaction [RORC protein binds to NPAS2 promoter]
CTD
PMID:29981919
NCBI chr 9:41,463,361...41,642,322
Ensembl chr 9:41,463,830...41,642,320
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Rorc
RAR-related orphan receptor C
increases expression multiple interactions
ISO
Digoxigenin results in increased expression of RORC mRNA Digoxigenin promotes the reaction [RORC protein binds to G6PC1 promoter]; Digoxigenin promotes the reaction [RORC protein binds to NPAS2 promoter]; RORC protein promotes the reaction [Digoxigenin results in increased expression of RORC mRNA]
CTD
PMID:29981919
NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907
G
Vegfa
vascular endothelial growth factor A
decreases expression
ISO
Digoxigenin results in decreased expression of VEGFA protein
CTD
PMID:20116850
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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