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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:eflornithine
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Accession:CHEBI:41948 term browser browse the term
Definition:A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
Synonyms:exact_synonym: 2,5-diamino-2-(difluoromethyl)pentanoic acid;   2-(difluoromethyl)ornithine
 related_synonym: DFMO;   DL-Ornithine, 2-(difluoromethyl)-;   Formula=C6H12F2N2O2;   InChI=1S/C6H12F2N2O2/c7-4(8)6(10,5(11)12)2-1-3-9/h4H,1-3,9-10H2,(H,11,12);   InChIKey=VLCYCQAOQCDTCN-UHFFFAOYSA-N;   SMILES=NCCCC(N)(C(F)F)C(O)=O;   alpha-(Difluoromethyl)-DL-ornithine;   alpha-difluoromethylornithine
 alt_id: CHEBI:41946;   CHEBI:4761
 xref: Beilstein:2250529;   CAS:67037-37-0;   CAS:70052-12-9;   DrugBank:DB03856;   Drug_Central:990;   KEGG:C07997;   KEGG:D07883
 xref_mesh: MESH:D000518
 xref: PDBeChem:DMO;   PMID:16541214;   PMID:23771434;   PMID:24144414;   Reaxys:2250529;   Wikipedia:Eflornithine


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eflornithine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mdm2 MDM2 proto-oncogene decreases expression EXP Eflornithine results in decreased expression of MDM2 mRNA CTD PMID:11502571 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Plcg1 phospholipase C, gamma 1 multiple interactions EXP [[Eflornithine results in decreased abundance of Polyamines] which results in decreased expression of and results in decreased activity of PLCG1 protein] which results in decreased abundance of Inositol 1,4,5-Trisphosphate; [Eflornithine results in decreased abundance of Polyamines] which results in decreased expression of and results in decreased activity of PLCG1 protein; [Eflornithine results in decreased abundance of Polyamines] which results in decreased expression of PLCG1 mRNA CTD PMID:16973916 NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
increases stability		 EXP Spermidine inhibits the reaction [Eflornithine results in increased expression of TP53 mRNA]
Eflornithine results in increased stability of TP53 mRNA; Eflornithine results in increased stability of TP53 protein		 CTD PMID:11502571 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19899
    role 19869
      biological role 19867
        antimicrobial agent 18269
          antimicrobial drug 11191
            antiprotozoal drug 7452
              trypanocidal drug 128
                eflornithine 3
                  eflornithine hydrochloride monohydrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19899
    subatomic particle 19897
      composite particle 19897
        hadron 19897
          baryon 19897
            nucleon 19897
              atomic nucleus 19897
                atom 19897
                  main group element atom 19835
                    main group molecular entity 19835
                      s-block molecular entity 19669
                        hydrogen molecular entity 19651
                          hydrides 19162
                            inorganic hydride 18183
                              pnictogen hydride 18173
                                nitrogen hydride 18086
                                  azane 17891
                                    ammonia 17890
                                      organic amino compound 17890
                                        amino acid 16079
                                          alpha-amino acid 13946
                                            non-proteinogenic alpha-amino acid 3805
                                              ornithine 12
                                                eflornithine 3
                                                  eflornithine hydrochloride monohydrate 0
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